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Sökning: WFRF:(Wei ZG)

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  • Wei, ZG, et al. (författare)
  • Expression of IgM, IgD, and IgY in a reptile, Anolis carolinensis
  • 2009
  • Ingår i: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 183:6, s. 3858-3864
  • Tidskriftsartikel (refereegranskat)abstract
    • The reptiles are the last major group of jawed vertebrates in which the organization of the IGH locus and its encoded Ig H chain isotypes have not been well characterized. In this study, we show that the green anole lizard (Anolis carolinensis) expresses three Ig H chain isotypes (IgM, IgD, and IgY) but no IgA. The presence of the δ gene in the lizard demonstrates an evolutionary continuity of IgD from fishes to mammals. Although the germline δ gene contains 11 CH exons, only the first 4 are used in the expressed IgD membrane-bound form. The μ chain lacks the cysteine in CH1 that forms a disulfide bond between H and L chains, suggesting that (as in IgM of some amphibians) the H and L polypeptide chains are not covalently associated. Although conventional IgM transcripts (four CH domains) encoding both secreted and membrane-bound forms were detected, alternatively spliced transcripts encoding a short membrane-bound form were also observed and shown to lack the first two CH domains (VDJ-CH3-CH4-transmembrane region). Similar to duck IgY, lizard IgY H chain (υ) transcripts encoding both full-length and truncated (IgYΔFc) forms (with two CH domains) were observed. The absence of an IgA-encoding gene in the lizard IGH locus suggests a complex evolutionary history for IgA in the saurian lineage leading to modern birds, lizards, and their relatives.
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