| 1. |
- Cai, Xiao, et al.
(författare)
-
Propagation of Darrieus-Landau unstable laminar and turbulent expanding flames
- 2021
-
Ingår i: Proceedings of the Combustion Institute. - : Elsevier BV. - 1540-7489. ; 38:2, s. 2013-2021
-
Tidskriftsartikel (refereegranskat)abstract
- The propagation of laminar and turbulent expanding flames subjected to Darrieus-Landau (DL), hydrodynamic instability was experimentally studied by employing stoichiometric H2/O2/N2 flames under quiescent and turbulent conditions performed in a newly developed medium-scale, fan-stirred combustion chamber. In quiescent environment, DL unstable laminar flame exhibits three-stage propagation, i.e. smooth expansion, transition acceleration, and self-similar acceleration. The self-similar acceleration is characterized by a power-law growth of acceleration exponent, α, with normalized Peclet number, which is different from the usually suggested self-similar propagation with a constant α. The imposed turbulence advances the onset of both transition acceleration and self-similar acceleration stages and promotes the strength of flame acceleration as additional wrinkles are invoked by turbulence eddies. A DL-turbulent interaction regime is confirmed to be the classical corrugated flamelets regime. Furthermore, the DL instability significantly facilitates the propagation of expanding flames in medium and even intense turbulence. The development of DL cells is not suppressed by turbulence eddies, and it needs to be considered in turbulent combustion.
|
|
| 2. |
|
|
| 3. |
- Geyer, Holly L., et al.
(författare)
-
Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms : an analysis by the MPN QOL International Working Group
- 2017
-
Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 102:1, s. 85-93
-
Tidskriftsartikel (refereegranskat)abstract
- The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on quality of life. The role gender plays in the symptomatology of myeloproliferative neoplasms remains under-investigated. In this study we evaluated how gender relates to patients' characteristics, disease complications and overall symptom expression. A total of 2,006 patients (polycythemia vera=711, essential thrombocythemia=830, myelofibrosis=460, unknown=5) were prospectively evaluated, with patients completing the Myeloproliferative Neoplasm-Symptom Assessment Form and Brief Fatigue Inventory Patient Reported Outcome tools. Information on the individual patients' characteristics, disease complications and laboratory data was collected. Consistent with known literature, most female patients were more likely to have essential thrombocythemia (48.6% versus 33.0%; P<0.001) and most male patients were more likely to have polycythemia vera (41.8% versus 30.3%; P<0.001). The rate of thrombocytopenia was higher among males than females (13.9% versus 8.2%; P<0.001) and males also had greater red-blood cell transfusion requirements (7.3% versus 4.9%; P=0.02) with shorter mean disease duration (6.4 versus 7.2 years, P=0.03). Despite there being no statistical differences in risk scores, receipt of most therapies or prior complications (hemorrhage, thrombosis), females had more severe and more frequent symptoms for most individual symptoms, along with overall total symptom score (22.8 versus 20.3; P<0.001). Females had particularly high scores for abdominal-related symptoms (abdominal pain/discomfort) and microvascular symptoms (headache, fatigue, insomnia, concentration difficulties, dizziness; all P<0.01). Despite complaining of more severe symptom burden, females had similar quality of life scores to those of males. The results of this study suggest that gender contributes to the heterogeneity of myeloproliferative neoplasms by influencing phenotypic profiles and symptom expression.
|
|
| 4. |
- Geyer, Holly L., et al.
(författare)
-
Distinct clustering of symptomatic burden among myeloproliferative neoplasm patients : retrospective assessment in 1470 patients
- 2014
-
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 123:24, s. 3803-3810
-
Tidskriftsartikel (refereegranskat)abstract
- Symptom burden in myeloproliferative neoplasms (MPNs) is heterogeneous even among patients within the same MPN diagnosis. Using cluster analysis from prospectively gathered symptom burden data in 1470 international patients with essential thrombocythemia (ET), polycythemia vera (PV), or myelofibrosis (MF), we assessed for the presence of clusters and relationship to disease features and prognosis. In MF (4 clusters identified), clusters significantly differed by Dynamic International Prognostic Scoring System (DIPSS) risk (P < .001), leukopenia (P = .009), thrombocytopenia (P < .001), and spleen size (P = .02). Although an association existed between clusters and DIPSS risk, high symptom burden was noted in some low and intermediate-1-risk MF patients. In PV (5 clusters identified), total symptom score increased across clusters (P < .001), but clusters did not significantly differ by PV risk or the risk assessment variable of age. Among ET patients (5 clusters identified), clusters differed by gender (P = .04), anemia (P = .01), and prior hemorrhage (P = .047). Total symptom score increased across clusters (P < .001), but clusters did not significantly differ by International Prognostic Score for ET risk including the risk assessment variables. Significant symptom heterogeneity exists within each MPN subtype, sometimes independent of disease features or prognosis.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Geyer, Holly L., et al.
(författare)
-
The role of sexuality symptoms in myeloproliferative neoplasm symptom burden and quality of life : An analysis by the MPN QOL International Study Group
- 2016
-
Ingår i: Cancer. - : Wiley. - 0008-543X .- 1097-0142. ; 122:12, s. 1888-1896
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUNDPatients with myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and myelofibrosis, are faced with oppressive symptom profiles that compromise daily functioning and quality of life. Among these symptoms, sexuality-related symptoms have emerged as particularly prominent and largely unaddressed. In the current study, the authors evaluated how sexuality symptoms from MPN relate to other patient characteristics, disease features, treatments, and symptoms. METHODSA total of 1971 patients with MPN (827 with essential thrombocythemia, 682 with polycythemia vera, 456 with myelofibrosis, and 6 classified as other) were prospectively evaluated and patient responses to the Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ C30) were collected, along with information regarding individual disease characteristics and laboratory data. Sexuality scores were compared with an age-matched, healthy control population. RESULTSOverall, patients with MPN were found to have greater sexual dysfunction compared with the healthy population (MPN-SAF score of 3.6 vs 2.0; P<.001), with 64% of patients with MPN describing some degree of sexual dysfunction and 43% experiencing severe symptoms. The presence of sexual symptoms correlated closely with all domains of patient functionality (physical, social, cognitive, emotional, and role functioning) and were associated with a reduced quality of life. Sexual problems also were found to be associated with other MPN symptoms, particularly depression and nocturnal and microvascular-related symptoms. Sexual dysfunction was more severe in patients aged >65 years and in those with cytopenias and transfusion requirements, and those receiving certain therapies such as immunomodulators or steroids. ConclusionsThe results of the current study identify the topic of sexuality as a prominent issue for the MPN population, and this area would appear to benefit from additional investigation and management. Cancer 2016;122:1888-96. (c) 2016 American Cancer Society. Sexuality problems impact all domains of functionality, depression, microvascular symptoms, and overall quality of life among patients with myeloproliferative neoplasms. These problems correlate with patient age, the presence of cytopenias, transfusion requirements, and common therapies for myeloproliferative neoplasms. See also pages 1804-6.
|
|
| 8. |
- Geyer, Holly, et al.
(författare)
-
Symptomatic Profiles of Patients With Polycythemia Vera : Implications of Inadequately Controlled Disease
- 2016
-
Ingår i: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 34:2, s. 151-
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) associated with disabling symptoms and a heightened risk of life-threatening complications. Recent studies have demonstrated the effectiveness of JAK inhibitor therapy in patients with PV patients who have a history of prior hydroxyurea (HU) use (including resistance or intolerance), phlebotomy requirements, and palpable splenomegaly. We aimed to determine how these features contribute alone and in aggregate to the PV symptom burden.PATIENTS AND METHODS: Through prospective evaluation of 1,334 patients with PV who had characterized symptom burden, we assessed patient demographics, laboratory data, and the presence of splenomegaly by disease feature (ie, known HU use, known phlebotomy requirements, splenomegaly).RESULTS: The presence of each feature in itself is associated with a moderately high symptom burden (MPN symptom assessment form [SAF] total symptom score [TSS] range, 27.7 to 29.2) that persists independent of PV risk category. In addition, symptoms incrementally increase in severity with the addition of other features. Patients with PV who had all three features (PV-HUPS) faced the highest total score (MPN-SAF TSS, 32.5) but had similar individual symptom scores to patients with known HU use (PV-HU), known phlebotomy (PV-P), and splenomegaly (PV-S).CONCLUSION: The results of this study suggest that patients with PV who have any one of the features in question (known HU use, known phlebotomy, or splenomegaly) have significant PV-associated symptoms. Furthermore, it demonstrates that many PV symptoms remain severe independent of the number of features present.
|
|
| 9. |
- Leebens-Mack, James H., et al.
(författare)
-
One thousand plant transcriptomes and the phylogenomics of green plants
- 2019
-
Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 574:7780, s. 679-
-
Tidskriftsartikel (refereegranskat)abstract
- Green plants (Viridiplantae) include around 450,000-500,000 species(1,2) of great diversity and have important roles in terrestrial and aquatic ecosystems. Here, as part of the One Thousand Plant Transcriptomes Initiative, we sequenced the vegetative transcriptomes of 1,124 species that span the diversity of plants in a broad sense (Archaeplastida), including green plants (Viridiplantae), glaucophytes (Glaucophyta) and red algae (Rhodophyta). Our analysis provides a robust phylogenomic framework for examining the evolution of green plants. Most inferred species relationships are well supported across multiple species tree and supermatrix analyses, but discordance among plastid and nuclear gene trees at a few important nodes highlights the complexity of plant genome evolution, including polyploidy, periods of rapid speciation, and extinction. Incomplete sorting of ancestral variation, polyploidization and massive expansions of gene families punctuate the evolutionary history of green plants. Notably, we find that large expansions of gene families preceded the origins of green plants, land plants and vascular plants, whereas whole-genome duplications are inferred to have occurred repeatedly throughout the evolution of flowering plants and ferns. The increasing availability of high-quality plant genome sequences and advances in functional genomics are enabling research on genome evolution across the green tree of life.
|
|
| 10. |
- Li, Fay-Wei, et al.
(författare)
-
Horizontal transfer of an adaptive chimeric photoreceptor from bryophytes to ferns
- 2014
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 111:18, s. 6672-6677
-
Tidskriftsartikel (refereegranskat)abstract
- Ferns are well known for their shade-dwelling habits. Their ability to thrive under low-light conditions has been linked to the evolution of a novel chimeric photoreceptor-neochrome-that fuses red-sensing phytochrome and blue-sensing phototropin modules into a single gene, thereby optimizing phototropic responses. Despite being implicated in facilitating the diversification of modern ferns, the origin of neochrome has remained a mystery. We present evidence for neochrome in hornworts (a bryophyte lineage) and demonstrate that ferns acquired neochrome from hornworts via horizontal gene transfer (HGT). Fern neochromes are nested within hornwort neochromes in our large-scale phylogenetic reconstructions of phototropin and phytochrome gene families. Divergence date estimates further support the HGT hypothesis, with fern and hornwort neochromes diverging 179 Mya, long after the split between the two plant lineages (at least 400 Mya). By analyzing the draft genome of the hornwort Anthoceros punctatus, we also discovered a previously unidentified phototropin gene that likely represents the ancestral lineage of the neochrome phototropin module. Thus, a neochrome originating in hornworts was transferred horizontally to ferns, where it may have played a significant role in the diversification of modern ferns.
|
|
| 11. |
- Lin, C., et al.
(författare)
-
Nano Pores Evolution in Hydroxyapatite Microsphere during Spark Plasma Sintering
- 2011
-
Ingår i: Science of Sintering. - 0350-820X. ; 43:1, s. 39-46
-
Tidskriftsartikel (refereegranskat)abstract
- Micron-spherical granules of hydroxyapatite (HAp) nanoparticles were prepared by powder granulation methods. Through subsequent sintering, porous HAp microspheres with tailored pore and grain framework structures were obtained. Detailed microstructure investigation by SEM and TEM revealed the correlation of the pore structure and the necking strength with the sintering profiles that determine the coalescence features of the nanoparticles. The partially sintered porous HAp microspheres containing more than 50% porosity consisting of pores and grains both in nano-scale are active in inducing the precipitation of HAp in simulated body fluid. The nano-porous HAp microspheres with an extensive surface and interconnecting pores thus demonstrate the potential of stimulating the formation of collagen and bone and the integration with the newly formed bones during physiological bone remodeling.
|
|
| 12. |
- Qian, Bin, et al.
(författare)
-
Assembled nano-structures from micron-sized precursors
- 2014
-
Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 4:58, s. 30754-30757
-
Tidskriftsartikel (refereegranskat)abstract
- Oriented assembly of small crystals to form larger structures are common in nature and full understanding and control of such process would be beneficial for the forthcoming nano-technologies. Such bottom-up assembly of nano-structures most often requires a precursor of nano-sized crystals. Here we demonstrate a novel laser sintering process that can rupture a submicron-sized zirconia precursor into nano-sized crystals, followed by a rapid oriented assembly of these small crystals. A detailed structure study has been carried out to understand the complex process and a model has been proposed. Such a process sheds light on a new way of fabricating nano-materials using commercialized oxide materials.
|
|
| 13. |
- Qian, Bin, et al.
(författare)
-
Defect-tolerant characteristics of laser sintered CoCrMo alloy ensured by strong structural hierarchies
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Laser sintering of a CoCrMo alloy have been found to introduce intergrown structural features on several length scales from nano- to macro-levels, i.e. structural hierarchies. The quenching of the small laser formed melting pool, when the laser focus spot moves away, will preserve high temperature phases or microstructures. A micron-sized cellular microstructure will form with Mo being enriched in a nanometer thin zone at the cell boundaries and carbide formation is suppressed. Clusters of elongated cells (crystallites) join along one common crystal structure direction forming larger up to 100 µm bundles and these grow in different intercrossing directions in the microstructure. The interlocked framework prohibits mechanical creep or deformation by sliding along weak structure planes and consumes the energy of a propagating crack. A macro-scale “weld line” structure can be formed in 3-dimensions by the bottom-up approach; the sintering of layer by layer with a tailored scan track. The sintered alloy contained three types of defects comprising micron sized voids or cracks occurring at the cluster boundaries and larger cracks at the “weld line” boundaries. Unexpected good mechanical properties are achieved despite the observed microstructural defects and the laser sintered Co-Cr-Mo alloy seems very defect tolerant. This positive effect is ascribed to the strong structural hierarchies found in the laser sintered CoCrMo alloy.
|
|
| 14. |
- Qian, Bin, et al.
(författare)
-
Defects-tolerant Co-Cr-Mo dental alloys prepared by selective laser melting
- 2015
-
Ingår i: Dental Materials. - : Elsevier BV. - 0109-5641 .- 1879-0097. ; 31:12, s. 1435-1444
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives. CrCoMo alloy specimens were successfully fabricated using selective laser melting (SLM). The aim of this study was to carefully investigate microstructure of the SLM specimens in order to understand the influence of their structural features inter-grown on different length scales ranging from nano-to macro-levels on their mechanical properties.Methods. Two different sets of processing parameters developed for building the inner part( core) and the surface (skin) of dental prostheses were tested. Microstructures were characterized by SEM, EBSD and XRD analysis. The elemental distribution was assessed by EDS line profile analysis under TEM. The mechanical properties of the specimens were measured.Results. The microstructures of both specimens were characterized showing formation of grains comprised of columnar sub-grains with Mo-enrichment at the sub-grain boundaries. Clusters of columnar sub-grains grew coherently along one common crystallographic direction forming much larger single crystal grains which are intercrossing in different directions forming an overall dendrite-like microstructure. Three types of microstructural defects were occasionally observed; small voids (<10 mu m), fine cracks at grain boundaries (<10 mu m) and cracks at weld line boundaries (>10 mu m). Despite the presence of these defects, the yield and the ultimate tensile strength (UTS) were 870 and 430 MPa and 1300 MPa and 1160 MPa, respectively, for the skin and core specimens which are higher than casted dental alloy.Significance. Although the formation of microstructural defects is hard to be avoided during the SLM process, the SLM CoCrMo alloys can achieve improved mechanical properties than their casted counterparts, implying they are defect-tolerant.
|
|
| 15. |
- Scotch, Allison H, et al.
(författare)
-
Symptom burden profile in myelofibrosis patients with thrombocytopenia : Lessons and unmet needs
- 2017
-
Ingår i: Leukemia Research. - : Elsevier BV. - 0145-2126 .- 1873-5835. ; 63, s. 34-40
-
Tidskriftsartikel (refereegranskat)abstract
- Myelofibrosis is a myeloproliferative neoplasm associated with progressive cytopenias and high symptom burden. MF patients with thrombocytopenia have poor prognosis but the presence of thrombocytopenia frequently precludes the use of JAK2 inhibitors. In this study, we assessed quality of life and symptom burden in 418 MF patients with (n = 89) and without (n = 329) thrombocytopenia using prospective data from the MPN-QOL study group database, including the Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) and Total Symptom Score (MPN10). Thrombocytopenia, defined as platelet count < 100 x10(9)/L (moderate 51-100 x 10(9)/L; severe <= 50 x10(9)/L), was associated with anemia (76% vs. 45%, p < 0.001), leukopenia (29% vs. 11%, p < 0.001), and need for red blood cell transfusion (35% vs. 19%, p = 0.002). Thrombocytopenic patients had more fatigue, early satiety, inactivity, dizziness, sad mood, cough, night sweats, itching, fever, and weight loss; total symptom scores were also higher (33 vs. 24, p < 0.001). Patients with severe thrombocytopenia were more likely to have anemia (86% vs. 67%, p = 0.04), leukopenia (40% vs. 20%, p = 0.04), and transfusion requirements (51% vs. 20%, p = 0.002) but few differences in symptoms when compared to patients with moderate thrombocytopenia. These results suggest that MF patients with thrombocytopenia experience greater symptomatic burden than MF patients without thrombocytopenia and may benefit from additional therapies.
|
|
| 16. |
- Tefferi, Ayalew, et al.
(författare)
-
Myeloproliferative neoplasms - a global view
- 2022
-
Ingår i: British Journal of Haematology. - Chichester, United Kingdom : Wiley-Blackwell. - 0007-1048 .- 1365-2141. ; 198:6, s. 953-564
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 17. |
|
|
| 18. |
|
|
