| 1. |
- Belushkin, A. V., et al.
(författare)
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A study of disorder effects at ferroelectric phase transition in BaTiO3
- 2006
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Ingår i: Physica. B, Condensed matter. - : Elsevier BV. - 0921-4526 .- 1873-2135. ; 385, s. 85-87
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Tidskriftsartikel (refereegranskat)abstract
- The total structure factor of BaTiO3 obtained by neutron powder diffraction in the temperature range 360-430 K in the vicinity of ferroelectric phase transition has been modeled by the reverse Monte Carlo method. A presence of disordered displacements of Ti atoms due to dynamical tetragonal elongations of unit cells and off-centered sites of Ti atoms in paraelectric phase in the vicinity of the ferroelectric phase transition was observed. Both features result in the anomalous increase of mean square displacements of Ti atoms and reflect the coexistence of displacive and order-disorder components in the ferroelectric phase transition.
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| 2. |
- Cong, D Y, et al.
(författare)
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Crystal structures and textures in the hot-forged Ni-Mn-Ga shape memory alloys
- 2006
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Ingår i: Metallurgical and Materials Transactions. A. - 1073-5623 .- 1543-1940. ; 37A:5, s. 1397-1403
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Tidskriftsartikel (refereegranskat)abstract
- Three ferromagnetic shape-memory alloys with the chemical compositions of Ni53Mn25Ga22, Ni48Mn30Ga22, and Ni48Mn25Ga22Co5 were prepared by the induction-melting and hot-forging process. The crystal structures were investigated by the neutron powder diffraction technique, showing that Ni53Mn25Ga22 and Ni48Mn25Ga22Co5 have a tetragonal, I4/mmm martensitic structure at room temperature, while Ni48Mn30Ga22 has a cubic, L2(1) austenitic structure at room temperature. The development of textures in the hot-forged samples shows the in-plane plastic flow anisotropy from the measured pole figures by means of the neutron diffraction technique. Significant texture changes were observed for the Ni48Mn25Ga22Co5 alloy after room temperature deformation, which is due to the deformation-induced rearrangements of martensitic variants. An excellent shape-memory effect (SME) with a recovery ratio of 74 pct was reported in this Ni48Mn25Ga22Co5 polycrystalline alloy after annealing above the martensitic transformation temperature, and the "shape-memory" influence also occurs in the distributions of grain orientations.
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| 3. |
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| 4. |
- Loeber, JG, et al.
(författare)
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Neonatal Screening in Europe Revisited: An ISNS Perspective on the Current State and Developments Since 2010
- 2021
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Ingår i: International journal of neonatal screening. - : MDPI AG. - 2409-515X. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Neonatal screening (NBS) was initiated in Europe during the 1960s with the screening for phenylketonuria. The panel of screened disorders (“conditions”) then gradually expanded, with a boost in the late 1990s with the introduction of tandem mass spectrometry (MS/MS), making it possible to screen for 40–50 conditions using a single blood spot. The most recent additions to screening programmes (screening for cystic fibrosis, severe combined immunodeficiency and spinal muscular atrophy) were assisted by or realised through the introduction of molecular technologies. For this survey, we collected data from 51 European countries. We report the developments between 2010 and 2020 and highlight the achievements reached with the progress made in this period. We also identify areas where further progress can be made, mainly by exchanging knowledge and learning from experiences in neighbouring countries. Between 2010 and 2020, most NBS programmes in geographical Europe matured considerably, both in terms of methodology (modernised) and with regard to the panel of conditions screened (expanded). These developments indicate that more collaboration in Europe through European organisations is gaining momentum. We can only accomplish the timely detection of newborn infants potentially suffering from one of the many rare diseases and take appropriate action by working together.
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| 5. |
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| 6. |
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| 7. |
- Zetterström, P., et al.
(författare)
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Nanoscale defect clusters in metallic glasses
- 2007
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Ingår i: Journal of Physics. - : IOP Publishing. - 0953-8984 .- 1361-648X. ; 19:37, s. 376217-
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Tidskriftsartikel (refereegranskat)abstract
- The reverse Monte Carlo method was used to obtain three-dimensional discrete distributions of constitutional atoms in melt-spun CuZr and CuZrTi metallic glasses from neutron and x-ray diffraction data. It was found that the icosahedral short-range order is less stable in the CuZr binary alloy than in the Ti-doped ternary alloy. The present investigation also provides evidence on the medium-range order, characterized by some nanoscale clusters of defects, in the metallic-glassy state.
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| 8. |
- Zetterström P, Soper A K, Schofield P
(författare)
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Inelastic neutron scattering of light and heavy water at high incident energies
- 1997
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Ingår i: Molecular Physics. - : Taylor & Francis Ltd. - 0026-8976. ; 90:5, s. 773-786
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Tidskriftsartikel (refereegranskat)abstract
- Inelastic neutron spectroscopy on pure light and heavy water and on mixtures is reported in this paper. The results are compared with calculations based on two models of the dynamic self-scattering law. Both models are connected to the mean kinetic energy
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| 9. |
- Zetterström P, Soper A K, Schofield P
(författare)
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Neutron Compton Scattering
- 1997
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Ingår i: Physica B. - : Elsevier Science BV. ; , s. 337-339
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Konferensbidrag (refereegranskat)abstract
- Neutron Compton scattering measurements on water (H2O and D2O) are presented. The measurements are compared with calculations of the Compton profiles based on two different models of the dynamic self-scattering law Sself(Q,omega). Both models depend
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| 10. |
- Zetterström P, Soper A K, Schofield P
(författare)
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Parametrisation of the van Hove dynamic scattering law S(Q,w)
- 1996
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Ingår i: Molecular Physics. - : Taylor & Francis Ltd. - 0026-8976. ; 88:6, s. 1621-
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we present a model of the Van Hove dynamic scattering law SME(Q,omega) based on the maximum entropy principle which is developed for the first time. The model is aimed to be used in the calculation of inelastic corrections to neutron diffrac
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| 11. |
- Belushkin, AV, et al.
(författare)
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A study of orientational disorder in ND4Cl by the reverse Monte Carlo method
- 1999
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Ingår i: PHYSICA B. - : ELSEVIER SCIENCE BV. - 0921-4526. ; 269:3-4, s. 297-303
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The total structure factor for deuterated ammonium chloride measured by neutron diffraction has been modeled using the reverse Monte Carlo method. The results show that the orientational disorder of the ammonium ions consists of a local librational motion
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| 12. |
- Belushkin, AV, et al.
(författare)
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Mechanism of superprotonic conductivity in CsHSO4
- 1998
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Ingår i: PHYSICA B. - : ELSEVIER SCIENCE BV. - 0921-4526. ; 241-243, s. 323-325
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Cesium hydrogen sulphate is one of the most extensively studied superprotonic conductors with hydrogen bonds. The first-order phase transition, from the low-conductivity to high conductivity phase takes place at 414 K. The crystallographic structure of bo
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| 13. |
- Bergh, Johan, 1983-, et al.
(författare)
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Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping
- 2015
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 112:14, s. 4489-4494
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Tidskriftsartikel (refereegranskat)abstract
- Despite considerable progress in uncovering the molecular details of protein aggregation in vitro, the cause and mechanism of protein-aggregation disease remain poorly understood. One reason is that the amount of pathological aggregates in neural tissue is exceedingly low, precluding examination by conventional approaches. We present here a method for determination of the structure and quantity of aggregates in small tissue samples, circumventing the above problem. The method is based on binary epitope mapping using anti-peptide antibodies. We assessed the usefulness and versatility of the method in mice modeling the neurodegenerative disease amyotrophic lateral sclerosis, which accumulate intracellular aggregates of superoxide dismutase-1. Two strains of aggregates were identified with different structural architectures, molecular properties, and growth kinetics. Both were different from superoxide dismutase-1 aggregates generated in vitro under a variety of conditions. The strains, which seem kinetically under fragmentation control, are associated with different disease progressions, complying with and adding detail to the growing evidence that seeding, infectivity, and strain dependence are unifying principles of neurodegenerative disease.
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| 14. |
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| 15. |
- Gudowski W, Mellergård A, Dzugutov M, Howells W S, Zetterström P
(författare)
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The structure of molten Bismuth-Lead alloys
- 1993
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Ingår i: Journal of Non-crystalline solids. ; 156, s. 130-
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Tidskriftsartikel (refereegranskat)
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| 16. |
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| 17. |
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| 18. |
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| 19. |
- McGreevy R L, Zetterström P
(författare)
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Reverse Monte Carlo modelling of networl glasses: useful or useless?
- 2001
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Ingår i: Journal of Non-Crystalline Solids. - : ELSEVIER SCIENCE. - 0022-3093. ; 293-295, s. 297-303
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Tidskriftsartikel (refereegranskat)abstract
- It has been ten years since the first reverse Monte Carlo (RMC) modelling study of a glass (vitreous silica) was published. The aim of that early work was twofold: firstly to assess whether the experimental data alone would support the continuous random n
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| 20. |
- Pedroletti, C, et al.
(författare)
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Clinical effects of purified air administered to the breathing zone in allergic asthma : A double-blind randomized cross-over trial
- 2009
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Ingår i: RESPIRATORY MEDICINE. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 103:9, s. 1313-1319
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Tidskriftsartikel (refereegranskat)abstract
- Background: Exposure to inhaled allergens is a pathogenetic factor in allergic asthma. However, most studies that previously looked at air cleaning devices have shown little or no effect on patients with perennial allergic asthma. Aims and objectives: We examined a novel treatment using temperature regulated laminar airflow with a very low particle concentration directed to the breathing zone of teenagers and young adults with mild to moderate allergic asthma during night steep. We hypothesised that the decreased allergen exposure during the night would have an effect on bronchial inflammation and quality of life. Method: Twenty-two patients (mean 18.8 years) were randomized to start with active or placebo treatment for 10 weeks. At( patients received both active and placebo treatment with unfiltered air, with a 2-week wash-out period in between treatments. Maintenance treatment with inhaled corticosteroids was unaltered during the trial period. Health related quality of life (miniAQLQ) was the primary effectiveness measure. Exhaled nitric oxide (FeNO) and spirometry were also investigated. Results: Active treatment resulted in an improved miniAQLQ compared to placebo (mean score 0.54, p andlt; 0.05, n = 20). An effect on bronchial, inflammation was also detected with significantly tower FeNO values during the active treatment period (mean -6.95 ppb, p andlt; 0.05, n = 22). Both effects were evident after 5 weeks. The change in lung function was not statistically significant. Conclusion: Clean air, administered directly to the breathing zone during steep, can have a positive effect on bronchial. inflammation and quality of life in patients with perennial allergic asthma.
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| 21. |
- Peng, Ru, 1960-, et al.
(författare)
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Crystal structure and phase transformation in Ni53Mn 25Ga22 shape memory alloy from 20 K to 473 K
- 2005
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 87:11
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Tidskriftsartikel (refereegranskat)abstract
- The crystal structures, magnetic structures, and phase transformation of the off-stoichiometric Ni53 Mn25 Ga22 were studied by neutron powder diffraction at different temperatures. It is shown that Ni53 Mn25 Ga22 has a tetragonal I4/mmm structure from 20 K to 403 K. An abrupt jump in unit-cell volume around room temperature, corresponding to an endothermic peak in the differential scanning calorimetry curve, was observed. This indicates a pretransformation in the martensitic phase of Ni53 Mn25 Ga22, which is completely different from the phase transformation in the stoichiometric Ni2 MnGa. The sequence of structural transformation in Ni53 Mn25 Ga22 is closely related to its intrinsic temperature-dependent magnetic structure. © 2005 American Institute of Physics.
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| 22. |
- Prieto, C, et al.
(författare)
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Structural order and chemical disorder in the mechanically alloyed Fe-Co-Cu nano-crystalline system
- 2001
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Ingår i: Recent Res. Devel. Non-Crystalline Solids. - : Transworld Research Network, Kerala, India. ; 1, s. 151-169
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we present a structural study of the formation of a metastable Fe-Co-Cu alloy that can be prepared by mechanical alloying. Several steps in the alloy formation are described by using three different techniques: X-ray absorption spectroscopy,
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| 23. |
- Rowe, AD, et al.
(författare)
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A Novel Approach to Improve Newborn Screening for Congenital Hypothyroidism by Integrating Covariate-Adjusted Results of Different Tests into CLIR Customized Interpretive Tools
- 2021
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Ingår i: International journal of neonatal screening. - : MDPI AG. - 2409-515X. ; 7:2
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Tidskriftsartikel (refereegranskat)abstract
- Newborn screening for congenital hypothyroidism remains challenging decades after broad implementation worldwide. Testing protocols are not uniform in terms of targets (TSH and/or T4) and protocols (parallel vs. sequential testing; one or two specimen collection times), and specificity (with or without collection of a second specimen) is overall poor. The purpose of this retrospective study is to investigate the potential impact of multivariate pattern recognition software (CLIR) to improve the post-analytical interpretation of screening results. Seven programs contributed reference data (N = 1,970,536) and two sets of true (TP, N = 1369 combined) and false (FP, N = 15,201) positive cases for validation and verification purposes, respectively. Data were adjusted for age at collection, birth weight, and location using polynomial regression models of the fifth degree to create three-dimensional regression surfaces. Customized Single Condition Tools and Dual Scatter Plots were created using CLIR to optimize the differential diagnosis between TP and FP cases in the validation set. Verification testing correctly identified 446/454 (98%) of the TP cases, and could have prevented 1931/5447 (35%) of the FP cases, with variable impact among locations (range 4% to 50%). CLIR tools either as made here or preferably standardized to the recommended uniform screening panel could improve performance of newborn screening for congenital hypothyroidism.
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| 24. |
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| 25. |
- Tangeraas, T, et al.
(författare)
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Performance of Expanded Newborn Screening in Norway Supported by Post-Analytical Bioinformatics Tools and Rapid Second-Tier DNA Analyses
- 2020
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Ingår i: International journal of neonatal screening. - : MDPI AG. - 2409-515X. ; 6:3, s. 51-
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Tidskriftsartikel (refereegranskat)abstract
- In 2012, the Norwegian newborn screening program (NBS) was expanded (eNBS) from screening for two diseases to that for 23 diseases (20 inborn errors of metabolism, IEMs) and again in 2018, to include a total of 25 conditions (21 IEMs). Between 1 March 2012 and 29 February 2020, 461,369 newborns were screened for 20 IEMs in addition to phenylketonuria (PKU). Excluding PKU, there were 75 true-positive (TP) (1:6151) and 107 (1:4311) false-positive IEM cases. Twenty-one percent of the TP cases were symptomatic at the time of the NBS results, but in two-thirds, the screening result directed the exact diagnosis. Eighty-two percent of the TP cases had good health outcomes, evaluated in 2020. The yearly positive predictive value was increased from 26% to 54% by the use of the Region 4 Stork post-analytical interpretive tool (R4S)/Collaborative Laboratory Integrated Reports 2.0 (CLIR), second-tier biochemical testing and genetic confirmation using DNA extracted from the original dried blood spots. The incidence of IEMs increased by 46% after eNBS was introduced, predominantly due to the finding of attenuated phenotypes. The next step is defining which newborns would truly benefit from screening at the milder end of the disease spectrum. This will require coordinated international collaboration, including proper case definitions and outcome studies.
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