| 1. |
- Adlerberth, Ingegerd, 1959, et al.
(författare)
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Intestinal colonization with Enterobacteriaceae in Pakistani and Swedish hospital-delivered infants.
- 1991
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 80:6-7, s. 602-10
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Tidskriftsartikel (refereegranskat)abstract
- Rectal cultures from Swedish and Pakistani hospital-delivered newborn infants were analysed regarding the early acquisition of enterobacteria. Swedish infants were delivered vaginally, Pakistani infants were delivered either vaginally or by caesarean section. The Swedish infants were all breast-fed, whereas breastfeeding was incomplete and often started late among the Pakistani infants. Both groups of Pakistani infants were more rapidly colonized with enterobacteria than were the Swedish infants. Cultures from Swedish infants seldom yielded more than one kind of enterobacteria; E. coli and Klebsiella were most frequently isolated. E. coli dominated in both Pakistani groups, but especially caesarean section delivered infants were in addition often colonized with Proteus, Klebsiella, Enterobacter or Citrobacter species. Breastfeeding from the first day of life reduced colonization with Klebsiella/Enterobacter/Citrobacter. The results suggest that environmental exposure, delivery mode and early feeding habits all influence the early intestinal colonization with enterobacteria.
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| 2. |
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| 3. |
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| 4. |
- Arvidsson, J, et al.
(författare)
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The first case of the Sanfilippo type C syndrome in Scandinavia
- 1983
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Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 72:2, s. 313-316
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Tidskriftsartikel (refereegranskat)abstract
- A Swedish patient with typical symptoms of the Sanfilippo Syndrome (Mucopolysaccharidosis III) is described. The early onset of the disease, the presence of hepatomegaly, early dementia and the absence of umbilical bernia are consistent with the subgroup Sanfilippo A. Enzyme studies indicate the diagnosis Sanfilippo C, and thus the patient represents a more severe form of this subgroup than any of the four other patients hitherto described in detail.
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| 5. |
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| 6. |
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| 7. |
- Domellöf, L, et al.
(författare)
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Local perineal actinomycosis
- 1974
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 63:3, s. 450-2
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Donnér, M, et al.
(författare)
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Platelet surface-bound IgG and platelet-specific IgG in plasma in childhood thrombocytopenia
- 1990
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Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 79:3, s. 328-334
-
Tidskriftsartikel (refereegranskat)abstract
- Quantification of platelet-bound immunoglobulin is widely used in the evaluation of thrombocytopenia. Several methods have been devised among which labelled ligand-binding assays seem to be most appropriate. In series of adult patients such assays have been shown to be superior in separating immune-thrombocytopenia from thrombocytopenia of non-immune causes. We studied 62 children with thrombocytopenia of various causes, using radiolabelled protein A as a ligand to measure platelet-surface bound IgG. The test was highly sensitive (93%) in detecting immune-thrombocytopenia. The specificity, however, was only 57%, which is less than in published studies of adults. In a number of cases presumed to be non-immune-thrombocytopenia, notably a few patients with leukaemia and bone marrow aplasia, we found increased amounts of platelet surface-bound IgG. The significance of this finding is not clear. An indirect assay measuring platelet-specific IgG in plasma was less sensitive (46%) but highly specific for immune-thrombocytopenia (89%). The measurements of platelet-surface-bound IgG and platelet-specific IgG in plasma are of limited diagnostic value in childhood thrombocytopenia but are useful in following the treatment in chronic ITP.
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| 9. |
- Eksmyr, R, et al.
(författare)
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Low molecular weight proteinuria and slight hyperlipoproteinemia in three mentally retarded brothers.
- 1976
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 65:4, s. 521-5
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Tidskriftsartikel (refereegranskat)abstract
- Mental retardation in combination with proteinuria and a slight hyperlipoproteinemia was found in three brothers. The increased urinary protein excretion was dominated by albumin and the low molecular weight proteins retinol-binding protein (RBP) and beta2-microglobulin, indicating the presence of proximal tubular dysfunction. However, there was no glucosuria, phosphaturia or amino aciduria and the renal concentrating and acidification capacities were normal. A kidney biopsy in one of the patients revealed morphologic evidence of glomerular damage but a normal tubular structure. A mild hyper-beta-lipoproteinemia was found in the patients but not in their healthy siblings. The cause of this syndrome, hitherto not described, is unknown.
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| 10. |
- Fernell, Elisabeth, 1948, et al.
(författare)
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Autistic symptoms in children with infantile hydrocephalus.
- 1991
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 80:4, s. 451-457
-
Tidskriftsartikel (refereegranskat)abstract
- From a population-based series of children with Infantile Hydrocephalus (IH) 69 patients (mean age 11.7 years) were examined with respect to the occurrence of autistic symptoms. Autistic symptomatology was evaluated according to a modified short Swedish version of the so-called Autism Behavior Checklist. Sixteen of the 69 IH children (23%) reached a score which was considered indicative of autistic symptoms (AS) in the child. This group was compared with the remaining 53 IH children without autistic symptoms (non AS). Significant differences were found between these two groups with respect to aetiological and clinical data. In the AS group 44% were born preterm as compared to 9% in the non AS group. CT scan showed major abnormalities in 64% of the AS children while this was present in 28% in the non AS group. The occurrence of major neuroimpairments--epilepsy, mental retardation and cerebral palsy--was 50%, 88% and 50% in the AS group as compared to 9%, 23% and 19% respectively in the non AS group. It was concluded that the more severe the brain damage in children with IH the more likely that autistic symptomatology would ensue. This implies that specific neuropsychiatric services to these families are required.
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| 11. |
- Fernell, Elisabeth, 1948, et al.
(författare)
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Epidemiology of infantile hydrocephalus in Sweden. I. Birth prevalence and general data.
- 1986
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 75:6, s. 975-981
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Tidskriftsartikel (refereegranskat)abstract
- The livebirth prevalence of infantile simple hydrocephalus (IH) was investigated in a Swedish population-based survey. The study comprised all liveborn infants with IH apparent before the age of one year and born in the study area between 1967-82. A total of 202 infants fulfilled these criteria; of these, 141 (70%) were born at term and 61 (30%) were preterm. The mean prevalence was 0.53 per 1,000, with a slightly increasing trend from 0.48 in 1967-70 to 0.63 in 1979-82. The increase was entirely referable to the preterm group, in which the prevalence rose from 0.13 per 1,000 in 1967-70 to 0.30 in 1979-82. There was no tendency to an increase in the term group. In 12 of 23 children born very preterm the origin of the IH was a diagnosed cerebral haemorrhage. This is compatible with the increased risk of the latter condition that has been found in very preterm newborns. The mortality among children with IH was highest before the age of one year (15%), after which it was 1.2% per year.
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| 12. |
- Fernell, Elisabeth, 1948, et al.
(författare)
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Epidemiology of infantile hydrocephalus in Sweden. II. Origin in infants born at term.
- 1987
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 76:3, s. 411-417
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Tidskriftsartikel (refereegranskat)abstract
- The aetiology of infantile hydrocephalus (IH) was studied in a population-based series of 141 children with IH, born at term in southwestern Sweden 1967-82. A prenatal aetiology was present in 81 children (57%), a pre- and perinatal in 6 (4%), a perinatal in 27 (19%), and a postnatal in 8 (6%); the origin in 19 children (13%) remained untraceable. A variety of aetiologies were revealed or indicated among prenatal conditions. The dominant intrauterine infection was toxoplasmosis. The predominant perinatal condition was posthaemorrhagic IH. The broad outline of outcome differed between pathogenetic groups. Children with a clear prenatal onset of IH were found to be at high risk for early death or multiple neurological impairments. Thirteen of 63 (21%) within this group had died before 2 years of age and 34 of the 50 (68%) survivors showed major neurological dysfunction. This contrasted to the incidences of 3% deaths and 30% sequelae in children with IH of other onset.
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| 13. |
- Fernell, Elisabeth, 1948, et al.
(författare)
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Epidemiology of infantile hydrocephalus in Sweden. III. Origin in preterm infants.
- 1987
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 76:3, s. 418-423
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Tidskriftsartikel (refereegranskat)abstract
- The aetiology of infantile hydrocephalus (IH) was studied in a population-based series of 61 children with IH born 1967-82 at less than 37 weeks of gestation. A prenatal origin was present in 17 children (28%), a pre- and perinatal in 17 (28%), a perinatal in 26 (43%) and a postnatal in one (1%). The predominant single cause was postaemorrhagic IH, which was diagnosed in 19 (31%). In addition, an undiagnosed cerebral haemorrhage was considered to be the cause in another 25%. The outcome differed between pathogenetic groups. Children with a clear onset of IH (pre-, peri- or postnatal) were found to be at high risk for early death or multiple impairments. Sixteen of 39 (41%) within these groups had died before 2 years of age and 18 of the 23 (78%) survivors showed major neurological dysfunction. This contrasted to no mortality and 41% major dysfunction in children with a less clear onset of IH. A new subgroup consisting of infants born before 28 weeks of gestation emerged in the early 1980s. All infants with IH in this group developed a severe multihandicap condition.
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| 14. |
- Fernell, Elisabeth, 1948, et al.
(författare)
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Infantile hydrocephalus--the impact of enhanced preterm survival.
- 1990
-
Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 79:11, s. 1080-1086
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Tidskriftsartikel (refereegranskat)abstract
- The epidemiology of infantile hydrocephalus (IH) in the birth years 1983-86 was investigated in the south-western health care region of Sweden. The study was made as a continuation of a previous one which had shown a significant increase in the prevalence of IH in 1967-82. That rise was entirely referable to the relatively larger number of preterm IH infants born in 1979-82 and was considered to be due to the enhanced survival, especially of very preterm infants. The present series comprised 57 liveborn IH infants--27 preterms and 30 born at term. The livebirth prevalence of IH was 0.64 per 1,000, 0.30 for preterm and 0.34 for fullterm infants. The high prevalence of preterm IH infants in 1979-82 had persisted, but had not increased further. This might indicate an improved outcome in preterm survivors in the period 1983-86, as the survival rate had continued to increase. The striking predominance of a perinatal aetiology of IH in very preterm infants could be confirmed: 90% had had intraventricular haemorrhages verified by ultrasound in the postpartum period. The outcome in very preterm surviving infants with IH was still alarmingly poor: 78% had cerebral palsy, 72% mental deficiency, and 56% epilepsy.
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| 15. |
- Gillberg, Christopher, 1950, et al.
(författare)
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Perceptual, motor and attentional deficits in seven-year-old children. Neurological screening aspects.
- 1983
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 72:1, s. 119-124
-
Tidskriftsartikel (refereegranskat)abstract
- In an extensive neuropsychiatric study of seven-year-old children, operational criteria for diagnosing minimal brain dysfunction (MBD) syndrome were used. Detailed behavioural assessment and meticulous neurological examination provided the basis for the MBD diagnosis. The time-consuming specialist examination by the child neurologist was considered too sophisticated for use in everyday clinical practice. Therefore, the results obtained at a short neurodevelopmental screening assessment performed by a child psychiatrist were analysed with the aim of finding a limited set of neurological examination items with high discriminating capacity detecting for MBD syndromes. A set of six such items (diadochokinesis, hopping on one leg, standing on one leg, cutting out a paper circle, associated movements when walking on lateral sides of feet and the labyrinth test of the WISC) produced a minimal rate of misclassified cases. It is argued that this discriminant set may be useful in everyday child psychiatric and pediatric assessment of children who raise suspicion of suffering from MBD.
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| 16. |
- Gillberg, Christopher, 1950, et al.
(författare)
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Perceptual, motor and attentional deficits in six-year-old children. Screening procedure in pre-school.
- 1982
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 71:1, s. 121-129
-
Tidskriftsartikel (refereegranskat)abstract
- 3 448 six-year-old Swedish children were screened for perceptual, motor and attentional deficits with the help of a questionnaire containing 34 yes-no questions. Epidemiological aspects of single symptoms and of groups of symptoms are presented. Boys displayed many more problems than girls. Children attending day nurseries had more problems than part-time pre-school children, particularly as regards attention and behaviour. 141 of the children- 82 with and 59 without questionnaire symptoms suggestive of so-called MBD-had been examined in an extended neuro-psychiatric study. A discriminant analysis of the questionnaire was performed for these 141 children which demonstrated that a set of 6 questions had a high discriminating capacity detecting for MBD-syndromes.
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| 17. |
- Greisen, G, et al.
(författare)
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EEG depression and germinal layer haemorrhage in the newborn
- 1987
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Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 76:3, s. 519-525
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Tidskriftsartikel (refereegranskat)abstract
- Amplitude integrated EEG (aEEG) recordings from 32 mechanically ventilated infants, gestational age 32 weeks or less, were analysed. All recordings were started within 24 h of birth and continued for at least 50 h. Germinal layer haemorrhage (GLH) was diagnosed by repeated ultrasonography. In six infants neither GLH nor hypocalcaemia were diagnosed; aEEG in these infants rapidly became more active after birth: at 30 h of age continuous background activity was present for more than 20% of the time, and a seizure-like pattern was exceptional. In seven infants without GLH but with hypocalcaemia and other signs of metabolic derangement, continuous background activity appeared later and seizure-like activity was frequent. In the infants with GLH, depression of the background activity was apparent. This finding was particularly distinct in the presence of severe haemorrhages. Four infants developed GLH after 30 h of age. All these infants had depressed aEEG before the development of GLH, with less than 20% continuous activity at 30 h of age. In ten infants an analysis of the aEEG during the occurrence of GLH was possible. In six of these, cortical electrical activity decreased. Due to the limitation of GLH timing, it was not possible to decide whether this decrease closely preceded or followed GLH. We suggest that GLH primarily occurs in brains with a preceding metabolic and neurophysiologic abnormality, and that further functional deterioration is caused by the most severe haemorrhages.
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| 18. |
- Hallberg, A, et al.
(författare)
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Natural killer cell activity and antibody-dependent cellular cytotoxicity in newborn infants
- 1982
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Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 71:3, s. 431-436
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Tidskriftsartikel (refereegranskat)abstract
- The ability of lymphocytes from the peripheral blood of preterm and term infants and adult women and men to mediate natural killing (NK) and K cell activity (antibody-dependent cellular cytotoxicity) was analysed in 4 hours 51Cr-release assays. K 562 cells were targets for NK activity. K cell activity was assayed on antibody-coated rat thymocytes. Lymphocytes from adult male donors were significantly more cytotoxic to K 562 cells than were lymphocytes from adult female donors. Lymphocytes from both preterm and term infants had significantly lower NK and K cell activity than lymphocytes from adult donors. During the first month of life no increase in NK activity or K cell activity occurred in 7 infants who were re-examined. It is concluded that neither NK nor K cell activities are fully developed during the first month of life.
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| 19. |
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| 20. |
- Helin, I, et al.
(författare)
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Outbreak of coxsackievirus A-14 meningitis among newborns in a maternity hospital ward
- 1987
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Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 76:2, s. 234-238
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Tidskriftsartikel (refereegranskat)abstract
- During the late winter of 1983, 16 newborns with vague symptoms of failure to thrive, reluctance to feed and a slight rise in body temperature, were found to have meningitis caused by Coxsackievirus A-14. The cerebrospinal fluid showed pleocytosis with polymorphonuclear cells in excess but was otherwise normal. The clinical course was uneventful in all infants, but two of them demonstrated clinical signs of incipient cerebral oedema during the acute phase of the illness. An electroencephalogram (EEG) during the initial course of the disease and at nine months of age was normal in all. During a follow-up period of 2 1/2 years they all developed normally and no sequelae were noted. The presentation also demonstrates the usefulness of Vero cells for the propagation of the responsible virus.
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| 21. |
- Hellström-Westas, Lena, et al.
(författare)
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Lidocaine for treatment of severe seizures in newborn infants. I. Clinical effects and cerebral electrical activity monitoring
- 1988
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Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 77:1, s. 79-84
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Tidskriftsartikel (refereegranskat)abstract
- The anticonvulsive effect of lidocaine was evaluated in 46 newborn infants with severe, recurrent seizures. Before the lidocaine all infants were being given phenobarbital, and 22 infants were also treated with diazepam. Different dosages of lidocaine were tested. A loading dose of 2 mg/kg followed by i.v. infusion of 6 mg/kg/hour was the most effective dosage and had an immediate anticonvulsive effect in 18 of 25 infants; within 30 min the same effect was attained in another five of the infants, with an overall seizure control in 92% of the sample population. During the lidocaine treatment cerebral electrical activity was followed continuously with a cerebral function monitor (CFM), which also enabled evaluation of the treatment. No serious side effects on blood-pressure, heart-rate or cerebral electrical activity were registered. For newborn infants with severe recurrent seizures not responding to other drugs, lidocaine is an effective additional mode of treatment.
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| 22. |
- Hellström-Westas, Lena, et al.
(författare)
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Silent seizures in sick infants in early life. Diagnosis by continuous cerebral function monitoring
- 1985
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Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 74:5, s. 741-748
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral electric activity was surveilled with a Cerebral Function Monitor (CFM) technique in 87 newborn infants under neonatal intensive care. A total of 26 infants had electrographical signs of repeated seizure activity. Among these infants 14 had periods of one hour or more of silent seizures activity. Among these infants 14 had periods of one hour or more of silent seizures, i.e. typical pattern of ictal epileptic activity on CFM without clinical symptoms or signs of convulsions. The occurrence of silent seizures and their pattern in relation to the clinical condition and management was unpredictable in most cases. Besides general limpness or flaccidity in an outward quiet baby these infants showed no clinical fits or clonic convulsions. The findings indicate that anticonvulsive therapy in small infants may be insufficient and need re-evaluation, since the long-term effect of silent seizures on cerebral function and activity is still uncertain.
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| 23. |
- Lannering, Birgitta, 1948, et al.
(författare)
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Early onset group B streptococcal disease. Seven year experience and clinical scoring system.
- 1983
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 72:4, s. 597-602
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Tidskriftsartikel (refereegranskat)abstract
- Early onset group B streptococcal disease was reviewed for the seven year period between 1975 to 1981 at Vanderbilt University Medical Center. One hundred and twenty cases were identified. The disease varied from asymptomatic bacteremia to fatal cardiopulmonary collapse. Factors associated with a poor outcome were prematurity, low Apgar score at 5 min, the presence of shock, leukopenia, rupture of membranes for more than 12 hours, and a delay in treatment after the onset of symptoms. A scoring system for probability of death based on these 6 factors was then developed. Over the seven year period mortality decreased from 50% to 10%. The only factor identified with the decrease in mortality was a significant decrease in the number of hours between the onset of symptoms and the beginning of treatment. Early recognition and prompt treatment seem to be the major causes of the decreasing mortality over the seven years of this report.
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| 24. |
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| 25. |
- Lindehammar, Hans
(författare)
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Hand strength in juvenile chronic arthritis : a two-year follow-up
- 2003
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Ingår i: Acta Paediatrica. - 0001-656X. ; 92:11, s. 1291-1296
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To describe changes in muscle strength in the hands of children with juvenile chronic arthritis (JCA) and to examine the relationship between muscle strength, presence of local arthritis and disease subtype. METHODS: Twenty children (10 girls and 10 boys) with JCA aged 7 to 18 y were followed for two years. Isometric muscle strength in wrist dorsiflexors and handgrip strength were measured repeatedly. The results were compared with reference values for the same methods. Arthritis severity in the hand was scored every third month. Nerve conduction velocities were measured twice. RESULTS: Seven out of 20 patients had initially low or decreasing strength in one or both of the two tests. Five out of 20 children had reduced strength (more than two standard deviations below the mean of the reference group) in at least one test. Four children showed a significant reduction in muscle strength in at least one test during the observation time. The greatest reduction in strength was measured in four children with polyarticular disease. These children also had local arthritis in the hand. A greater proportion of children with polyarthritis had low or decreasing strength compared with children with oligoarthritis. The same was true for children with active arthritis in the hand. Nerve conduction velocities were normal in all cases and did not change. CONCLUSION: The majority of children with JCA have normal strength in the hand. Some children, especially those with polyarthritis and hand arthritis, have reduced muscle strength in the hand. Risk factors for low or decreasing strength are polyarthritis and/or active arthritis in the hand.
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| 26. |
- Ljung, R., et al.
(författare)
-
Diagnostic symptoms of severe and moderate haemophilia A and B. A survey of 140 cases
- 1990
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 79:2, s. 196-200
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Tidskriftsartikel (refereegranskat)abstract
- With a view to the characterisation of presenting symptoms, a survey was made of 140 boys diagnosed as having haemophilia A or B, severe or moderate form, in Sweden during the years 1960-1987. Mean age at diagnosis was nine months for the severe cases and 22 months for the moderate cases. Although the heredity was known in 59/140 cases, 35 had had bleeding episodes before diagnosis had been established, thus emphasising the importance of genetic information and carrier identification in haemophilia families. Of the presenting symptoms, subcutaneous bleedings constituted 41% while joint and muscle bleedings were uncommon; 16% were bleedings in conjunction with puncture of vessels, injections or surgery. Fourteen percent had anaemia and received blood-transfusion at diagnosis; 9% were diagnosed post-neonatally but 20% had shown abnormal bleeding tendency already in the neonatal period; seven boys (5%) had intracranial haemorrhages, five of them neonatally. A thorough family history and an extensive investigation of bleedings in the neonatal period should make early diagnosis possible.
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| 27. |
- Ljung, R, et al.
(författare)
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Ganglioneuroma with an uncommon location in a six-year-old girl
- 1984
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 73:3, s. 3-411
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Tidskriftsartikel (refereegranskat)abstract
- A 6-year-old girl with a neurogenic bladder disease is described. Additional gait disturbances and mild but progressive foot deformities led to the diagnosis and surgical treatment of a ganglioneuroma located exclusively intraspinally. It is suggested that the tumor originated from remnant neural crest cells, probably early in life or even prenatally.
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| 28. |
- Ljung, Rolf, et al.
(författare)
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Immunoradiometric assay of inhibitors of antihaemophilic factor A
- 1982
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 71:6, s. 1019-1023
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Tidskriftsartikel (refereegranskat)abstract
- An immunoradiometric assay (IRMA) for determination of antibodies against f. VIII:C in haemophilia A was developed. The assay was based on competitive binding of radiolabelled anti-VIII:C and antibodies in the test material to immobilized VIII:C. Fifteen haemophiliacs with known inhibitors were investigated with the new method and with a conventional neutralization test. In 3 cases the inhibitors were detected only with the IRMA and in the other 12 there was good agreement between the inhibitor levels found with the two methods. It was also possible to demonstrate the antibodies in three non-haemophilic patients with acquired inhibitors. The IRMA, which can detect the antibodies down to a concentration of 0.02 inhibitor units per ml, is more sensitive than conventional neutralization tests and is thus of practical importance in the investigation of patients with low inhibitor titres.
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| 29. |
- Ljung, R., et al.
(författare)
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More than half the sporadic cases of Hemophilia A in Sweden are due to a recent mutation
- 1991
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Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 80:3, s. 343-348
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to ascertain how many of the sporadic cases of severe Haemophilia A in Sweden are due to recent mutation, and establish its origin. DNA analysis was performed in 18 randomly selected families with a sporadic case of severe haemophilia A. Restriction fragment length polymorphism (RFLP) patterns were investigated, two intragenic (Bc1 I, Xba I/Kpn I) and two extragenic (DX 13, St 14) RFLP being used. In 10/18 families a haemophilia-linked gene was found to have derived from the healthy maternal grandfather; on the basis of clotting and immunological assay results, the odds were high (>104:1) for maternal carriership in four of these 10 cases, and for maternal non-carriership in two, four being indeterminate. In 4/18 families a haemophilia-linked gene derived from the healthy maternal grandmother; according to clotting and immunological assay results, in two cases the odds were high for maternal non-carriership. In the remaining 4/18 families no conclusions could be drawn from the RFLP pattern as to the origin of mutation. We conclude that at least 55% of the sporadic cases of severe hemophilia A in Sweden are due to a recent mutation within the last two genrations.
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| 30. |
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| 31. |
- Mellander, Mats, 1947, et al.
(författare)
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Mineralization defects in deciduous teeth of low birthweight infants.
- 1982
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 71:5, s. 727-33
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Tidskriftsartikel (refereegranskat)abstract
- A group of 91 children with birthweights below 2000 g and 48 healthy full-term children, reference group, were examined for mineralization disturbances of the enamel of deciduous teeth. Perinatal data were collected retrospectively from obstetric and neonatal records. Within the low birthweight group, children with enamel hypoplasia had on the 5% level a significantly lower intake of breast milk during the first week of life than children without disturbances. The only perinatal complication associated with development of mineralization defects was IRDS. Infants with IRDS, however, had a significantly lower intake of breast milk during the first week of life than low birthweight without IRDS. A low frequency of enamel defects was found in the growth-retarded sub-group of the low birthweight infants. These infants had a significantly higher intake of breast milk during the first week compared to the AGA-group. A seasonal variation was found, with the highest prevalence of mineralization disturbances in infants born during winter months. It is concluded that the occurrence of mineralization defects of the deciduous teeth in LBW infants seems to be dependent upon the amount of breast milk given during the early neonatal period and also possibly in which season of the year they are born.
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| 32. |
- Moëll, Christian, et al.
(författare)
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Bcg vaccination as a cause of multifocal osteomyelitis in a 12-year-old girl
- 1983
-
Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 72:1, s. 153-155
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Tidskriftsartikel (refereegranskat)abstract
- A 12-year-old girl with multifocal skeletal sclerosis has been investigated. She was BCG vaccinated at birth and developed regional lymphadenitis in her left groin at two months of age. She was healthy until approximately 10 years of age, after which deficient height and weight gain occurred. BCG-itis was diagnosed in skeleton lesions. No evidence of immunodeficiency was found in the patient. After antituberculous treatment, the skeleton lesions, previously seen at bone scan, had disappeared. There has been a dramatic effect on her weight gain, growth and general well-being.
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| 33. |
- Mårdh, Per-Anders, et al.
(författare)
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Intrauterine lung infection with Chlamydia trachomatis in a premature infant
- 1984
-
Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 73:4, s. 569-572
-
Tidskriftsartikel (refereegranskat)abstract
- The present study shows the probable intrauterine infection with Chlamydia trachomatis in a premature infant born in the 29th week of gestation. Chlamydiae were isolated from lung tissue collected at sterile autopsy and also demonstrated in sections of such tissue by immunofluorescence tests using monoclonal antibodies.
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| 34. |
- Nordfeldt, Sam, et al.
(författare)
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Adverse events in intensively treated children and adolescents with type 1 diabetes
- 1999
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Ingår i: Acta Paediatrica. - 0001-656X. ; 88:11, s. 1184-1193
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Tidskriftsartikel (refereegranskat)abstract
- The main objective of this study was to examine the relation between adverse events and degree of metabolic control and multiple-dose treatment. A total of 139 children, aged between 1 and 18 y, prospectively registered severe hypoglycaemia with or without unconsciousness, as well as hospitalized ketoacidosis, during 1994-95. Treatment from onset was multiple-dose insulin (> 95% > or = 4 doses) combined with intense training and psychosocial support. Median HbA1c was 6.9% (ref. 3.6-5.4%). The incidence of severe hypoglycaemia with unconsciousness was 0.17 events per patient-year, having decreased from the 1970s to the 1990s, parallel to a change from 1-2 to > or = 4 doses per day. There was no correlation or association to the year mean HbA1c for severe hypoglycaemia. Severe hypoglycaemic episodes in 1995 correlated to severe hypoglycaemic episodes in 1994 (r=0.38; p<0.0001). Severe hypoglycaemia with unconsciousness increased during the spring season, and according to case records the assumed causes were mainly mistakes with insulin, food and exercise. Ketoacidosis was rare: 0.015 episodes per patient-year. We conclude that multiple-dose insulin therapy from the very onset of diabetes, combined with adequate self-control, active problem-based training and psycho-social support, may limit severe hypoglycaemia and ketoacidosis. Strategies aimed at minimizing severe hypoglycaemia without compromising metabolic control need to be evaluated.
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| 35. |
- Nordfeldt, Sam, et al.
(författare)
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Short-term effects of severe hypoglycaemia in children and adolescents with type 1 diabetes. A cost-of-illness study
- 2001
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Ingår i: Acta Paediatrica. - 0001-656X. ; 90:2, s. 137-142
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to describe costs and other short-term effects of severe hypoglycaemia in children and adolescents with type 1 diabetes. The study comprised a geographic population of 129 patients <19 y of age with families prospectively registering detailed data after self-reported severe hypoglycaemia. In the period Jan.-Dec. 1998, 16 events were reported with unconsciousness and 95 events without unconsciousness but needing the assistance of another person. Of all events, 20-30% had effects requiring the assistance of people other than parents, school absence, parents' absence from work, extra transport and/or telephone calls. Patient (family) activities were cancelled after 10% (5%) of events. Increased worry for parents was reported after 8% and poor sleep after 7% of events. Hospital visits took place at 5% and hospitalizations at 3% of all events. Patients with severe hypoglycaemia indicated lower global quality of life (p=0.0114). The average socio-economic burden for events of severe hypoglycaemia was estimated at EURO 17,400 yearly per 100 type 1 diabetes patients. Average cost was estimated at EURO 239 per event of severe hypoglycaemia with unconsciousness or EURO 478 yearly per patient with unconsciousness, and EURO 63 per event of severe hypoglycaemia without unconsciousness but needing assistance from another person or EURO 307 yearly per patient in this category. These are conservative estimates and do not include unpaid time and other intangibles, possible road traffic accidents, disabling or premature deaths. Conclusions: The results suggest the potential for socio-economic savings and increased quality of life for patients and families from severe hypoglycaemia prevention programs.
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| 36. |
- Norén, Jörgen G, 1947, et al.
(författare)
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Congenital hypothyroidism and changes in the enamel of deciduous teeth.
- 1983
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 72:4, s. 485-9
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Tidskriftsartikel (refereegranskat)abstract
- Deciduous teeth from children with congenital hypothyroidism were collected and ground sections were prepared. The sections were analysed by means of polarized light and microradiography. The enamel in ground sections of deciduous teeth from children with congenital hypothyroidism showed an increase in areas with elevated pore volume distribution in both the pre- and postnatal enamel. The findings suggest that thyroid hormone influences enamel maturation. Further, alterations in enamel structure, presumably due to prenatal thyroid deficiency, were found to be more common among children with neurological abnormalities at the age of 7 to 9 years.
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| 37. |
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| 38. |
- Persson, L A, et al.
(författare)
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From breastmilk to family food. Infant feeding in three Swedish communities.
- 1984
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 73:5, s. 685-92
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Tidskriftsartikel (refereegranskat)abstract
- The feeding habits of 312 Swedish infants have been followed longitudinally from birth to one year of age. The duration of breastfeeding had increased in comparison with the low figures in the beginning of the 1970s. Complementary foods were usually introduced from three months of age. At the age of 6 months all infants received complementary foods such as semi-solids and solids and about 90% were given follow-up formula. Parents belonging to higher socioeconomic strata were more prone to act in accordance with general feeding recommendations, e.g. regarding breastfeeding duration, time of introduction of complementary foods and gluten-containing foods and the use of sucrose-rich foods.
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| 39. |
- Persson, L A, et al.
(författare)
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Nutrition and health in Swedish children 1930-1980. Three nutrition surveys in a northern Swedish county.
- 1989
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 78:6, s. 865-72
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Tidskriftsartikel (refereegranskat)abstract
- In 1930 a nutrition survey was made of 1675 school children in the county of Västerbotten in northern Sweden. In 1967 a second survey was carried out in the same area, covering 1411 children aged 4, 8 and 13 years. A third survey was carried out in 1980 of 572 children in the same age groups. In the first survey questionnaires concerning food consumption were used, in the two later surveys 24-hour recall of food intake was recorded. Underweight and iron deficiency anaemia were prevalent in 1930. Since then socio-economic conditions have improved dramatically and dietary habits have become more diversified. In the last study the average energy intake had decreased from 100 to 87% of the RDA. A slight increase in the prevalence of overweight among 13-year-old children was also noted. The fat intake was lower in 1980 than in 1967, but the P/S-ratio was still low (0.23). The iron intake reached a satisfactory level in the two later studies and no case of iron-deficiency anaemia was found in 1980. In spite of a relatively frequent sucrose intake dental health had improved as a consequence of other prophylactic activities. The malnutrition problems of 1930 have been eradicated but new nutritional problems, linked to the risk of developing obesity and health problems in adulthood such as coronary heart disease, call for new preventive strategies.
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| 40. |
- Pettersson, F, et al.
(författare)
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Outcome of twin birth : Review of 1,636 children born in twin birth
- 1976
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 65:4, s. 473-79
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Tidskriftsartikel (refereegranskat)abstract
- During the five-year period 1964-68 96 733 births were registered in the 28 hospitals equipped with maternity facilities in the Uppsala hospital region. Of these babies, 1 636 were born in 818 twin deliveries. Data on gestational age, sex, weight and length at birth, birth order, hospital type, congenital malformations and perinatal mortality are analysed. Altogether 17.3 per 1 000 of the children born during this period were born in multiple births. The perinatal mortality for the twin babies was 64 per 1 000 born, with the mortality higher in the less specialized hospitals than the others. Twin no. 1 suffered perinatal death in 67 cases per 1 000 and twin no. 2 in 60 cases per 1 000. For twins of primiparae the losses were 92 per 1 000 children and for twins born to multiparae 51 per 1 000. Altogether 72 per 1 000 male twins died perinatally compared to 52 per 1 000 female twins. The most heavy losses occurred among the low-weight premature twins and in these cases both twins often suffered perinatal death.
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| 41. |
- Proos, Lemm A., 1943-, et al.
(författare)
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Menarcheal age and growth pattern of Indian girls adopted in Sweden. I. Menarcheal age.
- 1991
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 80:8-9, s. 852-8
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Tidskriftsartikel (refereegranskat)abstract
- The median menarcheal age of 107 girls adopted from India by families in Sweden was 11.6 years, which was significantly lower than in Swedish and most Indian studies. Five girls had menarche before the age of 9 years, the earliest at 7.3 years. Those who arrived at a later age had earlier menarche. No differences in menarcheal age were found with respect to geographic origin. The reasons for the earlier pubertal maturation are not clear. Factors associated with the rapid transition from an underprivileged to a privileged environment are probably involved, besides genetic determinants. The serious medical, social and emotional consequences of very early pubertal development necessitate further clarification of the underlying mechanisms.
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| 42. |
- Rasmussen, Peder, 1944, et al.
(författare)
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Perceptual, motor and attentional deficits in seven-year-old children. Paediatric aspects.
- 1983
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Ingår i: Acta Paediatrica Scandinavica. - 0001-656X. ; 72:1, s. 125-130
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Tidskriftsartikel (refereegranskat)abstract
- 42 children representative of Swedish urban seven-year-olds with a combination of various minor neurodevelopmental deficits in the form of so-called minimal brain dysfunction (MBD) syndromes were compared with 51 children of the same age without such problems as regards general health data from parents' interviews and questionnaires and from paediatric examinations. The findings at the physical examination revealed only few and small differences concerning minor physical anomalies that, in part, is dealt with in a separate report. Children with MBD had experienced simple febrile convulsions significantly more often than controls, and an abnormal EEG was a common finding in these cases. So-called psychosomatic complaints were not overrepresented in the MBD group, but enuresis and encopresis was somewhat more common. The parents' answers to a set of 6 questions (concerned with late speech development, late motor development, gross motor clumsiness, fine motor clumsiness, "shuffling" and difficulties to concentrate) were found to have a high discriminating capacity detecting for MBD syndromes. The possibility of a clinical application of this finding is discussed.
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| 43. |
- Rydén, Olof, et al.
(författare)
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Diabetic children and their parents: personality correlates of metabolic control
- 1990
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Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253. ; 79:12, s. 1204-1212
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Tidskriftsartikel (refereegranskat)abstract
- Test measures of field-dependence-independence and impulsiveness-control were obtained from two groups of diabetic children and their parents, the children being in optimal (O, n = 12) or poor (P. n = 27) metabolic control and, according to the judgment of clinicians, showing optimal or poor psychological adaptation. Children of the O-group scored lower in impulsiveness and higher in realistic functioning than those of the P-group. Differences which parallelled these were found between the two groups of fathers. The P-group fathers were decidedly more field-dependent than their wives, while the opposite was found for the O-group. Group differences of the kind obtained were seen as possible determinants of disturbed family interaction or emotional stress in the child in the P-group and of autonomy and self-reliance in the child in the O-group. It is concluded that the role of fathers of diabetic children has been underestimated.
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| 44. |
- Samuelson, Gösta, et al.
(författare)
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An epidemiological study of child health and nutrition in a northern Swedish county. : VII. A comparative study of general and dental health, food habits and socio-economic conditions in 4-year-old children.
- 1975
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 64:2, s. 241-7
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Tidskriftsartikel (refereegranskat)abstract
- A study of the general and dental health and the food habits of randomly selected 4-year-old Swedish urban children was performed. The results were compared with the findings of an investigation carried out four years earlier in the same area. In comparison with the earlier study no significant differences were found in haemoglobin values, packed red cell volume, microsedimentation rate and anthropometric measurements. The food habits had altered. A reduction in the frequency of between-meal consumption, particularly of sweets and soft drinks, as well as a reduction of the frequency of meat, fish and egg consumption was found. The children had an increased sandwich and milk consumption. The caries frequency was markedly reduced, which might be explained by the decreased between-meal consumption and an increased consumption of fluoride tablets. The food habits and the caries situation were generally influenced by the parents' socio-economic conditions, especially their educational level.
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| 45. |
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| 46. |
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| 47. |
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| 48. |
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| 49. |
- Sterky, G, et al.
(författare)
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The incidence of diabetes mellitus in Swedish children 1970--1975.
- 1978
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 67:2, s. 139-43
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Tidskriftsartikel (refereegranskat)abstract
- We report a retrospective study of diabetic children, 0--14 years of age, from seven Swedish departments of paediatrics. There were 359 new cases in the years 1970--1975. Notification suggested that there was a mean yearly incidence of 19.6 cases per 100 000 with a year to year variation of 10.0--26.4 per 100 000. Consequently about 330 new cases of childhood diabetes would be expected in Sweden every year. Incidence varied considerably between different geographical areas. The age distribution was bimodal with a main peak at about 12 years and another peak at about 7 years. There was some evidence for clustering of new cases in January and the autumn. The mean prevalence of childhood diabetes in the seven districts was 1.3 per 1 000.
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| 50. |
- Sunnegårdh, J, et al.
(författare)
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Physical activity in relation to energy intake and body fat in 8- and 13-year-old children in Sweden.
- 1986
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Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 75:6, s. 955-63
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Tidskriftsartikel (refereegranskat)abstract
- A random sample of 682 8- and 13-year-old children resident in Sweden was studied with regard to physical activity, energy intake, height, weight and skinfold thickness. A reduction of physical activity over the years was indicated by a tendency towards a higher body fat content in spite of a lower mean energy intake as compared with such values obtained 10-15 years ago in Swedish children of equal ages. Children characterized by high habitual physical activity tended to have a lower body fat content, despite a higher energy intake, than less active children. Children, especially girls, of parents with a low educational level showed a tendency towards higher body fat content as compared with those of parents with higher education.
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