| 1. |
|
|
| 2. |
|
|
| 3. |
- Colins, Olivier F., 1978-, et al.
(författare)
-
Psychiatric disorders in property, violent, and versatile offending detained male adolescents
- 2009
-
Ingår i: American Journal of Orthopsychiatry. - : American Psychological Association (APA). - 0002-9432 .- 1939-0025. ; 79:1, s. 31-38
-
Tidskriftsartikel (refereegranskat)abstract
- This study examines the past year prevalence rate of psychiatric disorders in detained male adolescents and the relation between psychiatric disorders and type of offending. The Diagnostic Interview Schedule for Children (DISC-IV) was administered in a sample (N = 245) of male detained adolescents aged 12 to 17 years. Based on lifetime official criminal history, participants were classified into property, violent, and versatile subgroups. High rates of psychiatric disorders were found in all groups. In addition, property offenders reported significantly higher rates of depression, disruptive behavior disorders, substance use disorders and comorbidity than violent and versatile offenders. Overall, versatile offenders did not differ from violent offenders, with the exception of more marijuana use disorder found in violent offenders. This study once more emphasizes that detained boys have substantial mental health needs, a finding that is generalizable across countries. In addition, the current study suggests that classifying detained juveniles by offense subgroups may carry clinical relevance. The long-term impact of these differences, and the possible effects of intervention, should be subject of further research.
|
|
| 4. |
- Fanti, Kostas A., et al.
(författare)
-
Stability and Change in Callous-Unemotional Traits : Longitudinal Associations With Potential Individual and Contextual Risk and Protective Factors
- 2017
-
Ingår i: American Journal of Orthopsychiatry. - : American Psychological Association (APA). - 0002-9432 .- 1939-0025. ; 87:1, s. 62-75
-
Tidskriftsartikel (refereegranskat)abstract
- This longitudinal study examines developmental heterogeneity in callous-unemotional (CU) traits in a large sample of school-age children in Cyprus. Latent Class Growth Analysis revealed 4 trajectory groups of CU traits across 3 time points: stable high, increasing, decreasing, and low. Findings suggested that children in the stable high CU trajectory were more likely to (a) exhibit high and stable levels of conduct problems, attention-deficit/hyperactivity disorder symptoms, impulsivity and narcissism, (b) experience low parental involvement and high parental distress, (c) report low peer support and school connectedness, and (d) score lower on academic performance, executive functioning, social competence, and self-regulation compared to children with low, decreasing, and increasing CU traits. These findings were verified by both parent and child reports. Repeated analysis of variance suggested that increases and decreases in CU traits were associated with similar changes in conduct problems, narcissism, impulsivity, and maternal involvement. Further, children in the decreasing trajectory group were not differentiated from children in the low risk group on measures of executive functioning, academic performance, school connectedness, and peer social support at the last wave of measurement. These findings provide evidence for the importance of taking longitudinal change into account for understanding developmental heterogeneity in CU traits and the association of these traits with possible protective (e.g., stable high maternal involvement) and risk (e.g., decreases in maternal involvement and increases in conduct problems, impulsivity and narcissism) variables.
|
|
| 5. |
- Frogner, Louise, 1983-, et al.
(författare)
-
Childhood Psychopathic Personality and Callous-Unemotional Traits in the Prediction of Conduct Problems
- 2018
-
Ingår i: American Journal of Orthopsychiatry. - : American Psychological Association (APA). - 0002-9432 .- 1939-0025. ; 88:2, s. 211-225
-
Tidskriftsartikel (refereegranskat)abstract
- This study analyzed data from a prospective longitudinal study of Swedish preschoolers to examine whether psychopathic traits and concurrent conduct problems predict future conduct problems (CP) across 1- and 2-year follow-ups into early childhood. We tested the predictive ability of psychopathic traits while controlling for concurrent CP, and also by combining psychopathic traits with concurrent CP. A community sample of 1,867 preschoolers (47% girls) ages 3 to 5 years at baseline was recruited from a Swedish medium-sized municipality. Results from multivariate regression analyses showed that psychopathic traits alone (without co-occurring CP) did not consistently predict continuing childhood CP, but did so, among both boys and girls, in combination with concurrent conduct problems. It is important to note that, the combination of concurrent CP and the entire psychopathic personality, that is, a 3-dimensional psychopathic construct, was a stronger predictor of continuing childhood CP than the combination of concurrent CP and Callous-Unemotional (CU) traits among boys but not among girls.
|
|
| 6. |
- Gustafsson, Per E., 1981-, et al.
(författare)
-
Sociocultural Disadvantage, Traumatic Life Events, and Psychiatric Symptoms in Preadolescent Children
- 2009
-
Ingår i: American Journal of Orthopsychiatry. - : American Psychological Association (APA). - 0002-9432 .- 1939-0025. ; 79:3, s. 387-397
-
Tidskriftsartikel (refereegranskat)abstract
- Previous research has demonstrated impact of psychosocial adversity on the mental health of children. This cross-sectional study examined the differential relationships between life-time exposure to interpersonal and non-interpersonal traumatic life events as well as sociocultural factors (family social class and immigrant family), and the level of externalizing versus internalizing symptoms. Participants included 258 children aged 6 to 12 years from two Swedish elementary schools. Information was obtained from their parents by means of questionnaires (a demographic form including information about parental occupation and country of origin, the Strengths and Difficulties Questionnaire and the Life Incidence of Traumatic Events checklist). While controlling for gender, age and the other symptom dimension, the sociocultural factors were associated to internalizing but not to externalizing symptoms. In contrast, traumatic life events and especially interpersonal traumas related to externalizing symptoms but not to internalizing symptoms. These findings provide some support for specificity of psychosocial adversities and for the importance of interpersonal traumas, in the impact on child mental health.
|
|
| 7. |
- Krabbendam, Anne A, et al.
(författare)
-
Personality disorders in previously detained adolescent females : a prospective study
- 2015
-
Ingår i: American Journal of Orthopsychiatry. - : American Psychological Association (APA). - 0002-9432 .- 1939-0025. ; 85:1, s. 63-71
-
Tidskriftsartikel (refereegranskat)abstract
- This longitudinal study investigated the predictive value of trauma and mental health problems for the development of antisocial personality disorder (ASPD) and borderline personality disorder (BPD) in previously detained women. The participants were 229 detained adolescent females who were assessed for traumatic experiences and mental health problems (mean age = 15.5 years). Three to 6 years later (M = 4.5; SD = 0.6), ASPD and BPD were diagnosed with a semistructured interview. Forty percent of the women had a personality disorder (i.e., ASPD 15.8%, BPD 9.2%, or both ASPD and BPD 15.2%). Posttraumatic stress, depressive symptoms, and dissociation during detention increased the risk for BPD in adulthood. Surprisingly, neither conduct problems nor substance dependence predicted ASPD; these findings require further study because they add to the controversy surrounding ASPD in females. The high prevalence rates of personality disorders indicate the need for intervention programs that target these unwanted outcomes.
|
|
| 8. |
- la Roi, Chaïm, et al.
(författare)
-
Differences in sexual identity dimensions between bisexual and other sexual minority individuals : Implications for minority stress and mental health
- 2018
-
Ingår i: American Journal of Orthopsychiatry. - : American Psychological Association (APA). - 0002-9432 .- 1939-0025. ; 89:1, s. 40-51
-
Tidskriftsartikel (refereegranskat)abstract
- Bisexual individuals experience poorer mental health than other sexual minority individuals. One explanation for this is that biphobia predisposes bisexual individuals to have a more ambiguous sexual identity and fewer opportunities for stress-ameliorating forms of coping and support. This study explores sexual identity and sexual identity dimensions-prominence, valence, integration, and complexity-in bisexual and other sexual minority individuals. We describe differences in sexual identity dimensions between bisexual and other sexual minority individuals and test two explanations for mental health disparities between them: whether sexual identity dimensions directly impact mental health and whether they moderate the impact of stress on mental health. Data came from a longitudinal study of a diverse sample of sexual minority individuals (N = 396, 71 bisexual respondents) sampled from community venues in New York City. Sexual identity was prominent for both bisexual and other sexual minority individuals, but bisexual individuals reported lower valence and integration of sexual identity in their identity structures. The hypothesis that sexual identity dimensions moderate the impact of minority stress on mental health was not supported. After several longitudinal assessments, however, we concluded that identity valence (but not integration or complexity) and depressive symptoms were bidirectionally associated so that differences in valence between bisexual and other sexual minority individuals explained, in part, disparities in depressive symptoms. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
|
|
| 9. |
- Rakhlin, Natalia, et al.
(författare)
-
Sources of Heterogeneity in Developmental Outcomes of Children With Past and Current Experiences of Institutionalization in Russia : A Four-Group Comparison
- 2017
-
Ingår i: American Journal of Orthopsychiatry. - : AMER PSYCHOLOGICAL ASSOC. - 0002-9432 .- 1939-0025. ; 87:3, s. 242-255
-
Tidskriftsartikel (refereegranskat)abstract
- The present study sought to compare 4 groups of age-and gender-matched children-(a) those reared in institutions for children without parental care in Russia; (b) those raised by their biological parents in Russia; (c) those adopted to the United States from Russian institutions; and (d) those born in the United States and raised by their biological parents-on indicators of cognition, language, and early learning. In addition, we aimed to compare the effects of the length of time spent in an institution, the age of initial placement in an institution, the age at adoption, and pre-institutional risk factors (i.e., prenatal substance exposure and prematurity and low birth weight) on the above-mentioned outcomes in the 2 groups of children with institutionalization experiences. Our results confirm previous reports demonstrating negative consequences of institutionalization and substantial ameliorating effects of adoption. They also underscore the complexity of the effects of institutionalization and adoption, showing that they are intertwined with the effects of pre-institutional risk factors.
|
|
| 10. |
|
|
| 11. |
- Orho-Melander, Marju, et al.
(författare)
-
Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels.
- 2002
-
Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 51:8, s. 2658-2664
-
Tidskriftsartikel (refereegranskat)abstract
- The calpain-10 gene (CAPN10) has been associated with type 2 diabetes, but information on molecular and physiological mechanisms explaining this association is limited. Here we addressed this question by studying the role of CAPN10 for phenotypes associated with type 2 diabetes and free fatty acid (FFA) metabolism. Among 395 type 2 diabetic patients and 298 nondiabetic control subjects from Finland, the SNP-43 allele 1 (P = 0.011), SNP-63 allele 2 (P = 0.010), and the haplotype combination SNP-44/43/19/63 1121/1121 (P = 0.028) were associated with type 2 diabetes. The SNP-43 genotypes 11 and 12 were associated with higher fasting insulin and homeostasis model assessment (HOMA) insulin resistance index among control subjects (P = 0.021 and P = 0.0076) and with elevated FFA among both control subjects (P = 0.0040) and type 2 diabetic patients (P = 0.0025). Multiple regression analysis further indicated that SNP-43 is an independent predictor of FFA levels (P = 0.0037). Among 80 genotype discordant sibling pairs, the SNP-43 allele 1 was associated with elevated fasting serum insulin and HOMA index (P = 0.013 and P = 0.0068). None of the four SNPs showed distorted transmission of alleles to patients with type 2 diabetes in a qualitative transmission disequilibrium test, including 108 trios. Because FFA and insulin resistance are known to predict type 2 diabetes, the finding that variation in the CAPN10 gene influences FFA levels and insulin resistance may provide an explanation for how the CAPN10 gene increases susceptibility to type 2 diabetes.
|
|
| 12. |
- Kolak, Maria, et al.
(författare)
-
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity
- 2007
-
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 56:8, s. 1960-1968
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: We sought to determine whether adipose tissue is inflamed in individuals with increased liver fat (LFAT) independently of obesity.RESEARCH DESIGN AND METHODS: A total of 20 nondiabetic, healthy, obese women were divided into normal and high LFAT groups based on their median LFAT level (2.3 +/- 0.3 vs. 14.4 +/- 2.9%). Surgical subcutaneous adipose tissue biopsies were studied using quantitative PCR, immunohistochemistry, and a lipidomics approach to search for putative mediators of insulin resistance and inflammation. The groups were matched for age and BMI. The high LFAT group had increased insulin (P = 0.0025) and lower HDL cholesterol (P = 0.02) concentrations.RESULTS: Expression levels of the macrophage marker CD68, the chemokines monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha, and plasminogen activator inhibitor-1 were significantly increased, and those of peroxisome proliferator-activated receptor-gamma and adiponectin decreased in the high LFAT group. CD68 expression correlated with the number of macrophages and crown-like structures (multiple macrophages fused around dead adipocytes). Concentrations of 154 lipid species in adipose tissue revealed several differences between the groups, with the most striking being increased concentrations of triacylglycerols, particularly long chain, and ceramides, specifically Cer(d18:1/24:1) (P = 0.01), in the high LFAT group. Expression of sphingomyelinases SMPD1 and SMPD3 were also significantly increased in the high compared with normal LFAT group.CONCLUSIONS: Adipose tissue is infiltrated with macrophages, and its content of long-chain triacylglycerols and ceramides is increased in subjects with increased LFAT compared with equally obese subjects with normal LFAT content. Ceramides or their metabolites could contribute to adverse effects of long-chain fatty acids on insulin resistance and inflammation.
|
|
| 13. |
- Häggström, Jens
(författare)
-
Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels.
- 2017
-
Ingår i: Journal of Veterinary Internal Medicine. - : Wiley. - 0891-6640 .- 1939-1676. ; 31, s. 1008-1016
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Development and progression of myxomatous mitral valve disease (MMVD) in dogs are difficult to predict. Identification at a young age of dogs at high risk of adverse outcome in the future is desirable.Hypothesis/Objectives: To study the predictive value of selected clinical and echocardiographic characteristics associated with MMVD obtained at a young age for prediction of long-term cardiac and all-cause mortality in Cavalier King Charles Spaniels (CKCS).Animals: 1125 privately owned CKCS.Methods: A retrospective study including CKCS examined at the age of 1-3 years. Long-term outcome was assessed by telephone interview with owners. The value of variables for predicting mortality was investigated by Cox proportional hazard and Kaplan-Meier analyses.Results: Presence of moderate to severe mitral regurgitation (MR) (hazard ratio (HR) = 3.03, 95% confidence interval (95% CI) = 1.48-6.23, P = 0.0025) even intermittent moderate to severe MR (HR = 2.23, 95% CI = 1.48-6.23, P = 0.039) on color flow Doppler echocardiography was significantly associated with increased hazard of cardiac death. An interaction between MR and sex was significant for all-cause mortality (P = 0.035), showing that males with moderate to severe MR had a higher all-cause mortality compared to males with no MR (HR = 2.38, 95% CI = 1.27-4.49, P = 0.0071), whereas no difference was found between female MR groups. The risk of cardiac (HR = 1.37, 95% CI = 1.14-1.63, P < 0.001) and allcause (HR = 1.13, 95% CI = 1.02-1.24, P = 0.016) mortality increased with increasing left ventricular end-systolic internal dimension normalized for body weight (LVIDSN).Conclusions and clinical importance: Moderate to severe MR, even if intermittent, and increased LVIDSN in dogs <3 years of age were associated with cardiac death later in life in CKCS.
|
|
