| 1. |
- Albeck, M J, et al.
(författare)
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Billeddiagnostik ved mistanke om lumbal diskusprolaps. En kontrolleret sammenligning af myelografi, CT og magnetisk resonans-billeddannelse
- 1996
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 158:10, s. 1362-1362
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Tidskriftsartikel (refereegranskat)abstract
- Eighty patients with monoradicular sciatica were examined by myelography, computed tomography (CT) and magnetic resonance imaging (MRI) and all had subsequent surgery. The images were evaluated by a decision-analytic regret function. The largest amount of diagnostic information was gained from CT followed by MRI and myelography. Myelography was not significantly informative. The results suggest that CT or MRI should be the first choice examination in patients with suspected lumbar disc herniation.
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| 2. |
- Backer, Vibeke, et al.
(författare)
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Får man astma af at dyrke topidræt?
- 2006
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 168:51, s. 4532-4532
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Abstract in Danish I de industrialiserede lande har 7-10% af den voksne befolkning astma, og tallet har de seneste årtier været stigende [1]. Lægediagnosticeret astma i Danmark er øget fra 4 til 7-10%, og allergisk rinitis eller kronisk ikkeallergisk rinitis er øget fra 10% til 20-25% over en 20-årig periode [2]. Astma er den hyppigste kroniske sygdom hos unge og unge voksne, og en høj forekomst af astma i befolkningen må naturligt følges af en høj forekomst af astma hos idrætsudøvere, men astma er ikke noget, som idrætsudøvere generelt synes at have forud for deres debut som eliteidrætsudøvere.
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| 3. |
- Bashir, Khuram, et al.
(författare)
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Stressfraktur i bilateral rami hos en kvinde med anorexia nervosa
- 2019
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Ingår i: Ugeskrift for læger. - : Den Almindelige Danske Laegeforening. - 0041-5782 .- 1603-6824. ; 181:12
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Tidskriftsartikel (refereegranskat)abstract
- This is a case report of a 51-year-old woman with bilateral stress fractures of the pelvic rami and a history of anorexia nervosa (AN). AN is a psychiatric condition of low weight caused by restricted food intake, impaired body image and an exaggerated fear of gaining weight in addition to compensating behaviour such as excessive physical activity. Among patients with AN, reduced bone density is common, and a higher risk of fractures is present. Stress fractures should be suspected in patients, who have AN and experience pain from the musculoskeletal system without a history of trauma.
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| 4. |
- Bendtzen, Klaus, et al.
(författare)
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Behandling af reumatoid artrit med anti-tumornekrosefaktor-alpha-antistof. Individuel monitorering af biotilgaengelighed og immunogenicitet-- sekundaerpublikation
- 2007
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Ingår i: Ugeskrift for Laeger. - 0041-5782. ; 169:5, s. 420-423
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Tidskriftsartikel (refereegranskat)abstract
- Remicade/infliximab is effective in rheumatoid arthritis (RA), but response failure is frequent. Sera from 106 RA patients were monitored using an RIA for functional infliximab and an RIA for anti-infliximab antibody (Ab). S-infliximab varied considerably, e.g. 0-22 microg/ml before the 3rd infusion, and 44% were Ab-positive after 6 months. Low s-infliximab was associated with Ab development and later therapeutic failure, and high Ab levels could be related to dose increases, side-effects and cessation of therapy. Pharmacological monitoring should help optimize anti-TNF therapies.
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| 5. |
- Binzer, MN, et al.
(författare)
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[Psychogenic paralysis. A prospective study].
- 2000
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Ingår i: Ugeskrift for læger. - 0041-5782 .- 1603-6824. ; 162:42, s. 5632-5636
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Tidskriftsartikel (refereegranskat)abstract
- The results of this study stresses the need for careful and well-conducted neurological and psychiatric assessments in patients with psychogenic paralyses, bearing in mind the substantial possibility for coinciding illnesses. If this is ensured, it appears that the risk of subsequent neurological rediagnosis is negligible.
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| 6. |
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| 7. |
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| 8. |
- Dahlin, L., et al.
(författare)
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Handtransplantation och implantation av nervchips. Flera nyheter på väg inom handkirurgin.
- 2000
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Ingår i: Ugeskrift for Laeger. - 0041-5782. ; 162:12, s. 1725-1730
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Forskningsöversikt (refereegranskat)abstract
- Injuries and diseases of the hand naturally have an enormous impact on hand function and on quality of life, both occupational and social. The majority of hand-injury patients are under 30 years of age. Hand surgery, an established specialty in Sweden since 1969, is of great importance in terms of clinical developments, education and research. In the coming decade, scientific and clinical advances are to be expected in several fields such as nerve injuries including brachial plexus lesion, microsurgery, flexor tendon injuries and tendon transfer. Bioimplant research and new advances at the biotechnological interface will yield new options in nerve reconstruction, microchip implants in the nervous system, and the restoration of muscle-tendon function following injury. Artificial limbs with advanced motor and sensory functions will be important future aids in the rehabilitation of amputees. Transplantation of human hands is another promising reconstructive procedure which may open iup new perspectives in the coming millennium.
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| 9. |
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| 10. |
- Dines, Laura Marie, et al.
(författare)
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Oncoplastic breast surgery for patients with breast cancer
- 2023
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Ingår i: Ugeskrift for Laeger. - 0041-5782. ; 185:34
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Forskningsöversikt (refereegranskat)abstract
- Lifetime risk of developing breast cancer for Danish women is approx. 9%. Diagnostics are done by mammography, biopsy, and examination. Breast-conserving surgery followed by radiotherapy is standard for treatment of early-stage breast cancer. Studies report unsatisfying outcomes in up to one third of the patients. This review summarises the current surgical techniques. Oncoplastic breast surgery makes it possible to combine wide-margin oncological surgery with immediate partial breast reconstruction, thus improving cosmetic outcome. Techniques involve volume reduction, volume displacement and volume replacement, depending on breast size and tumour characteristics.
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| 11. |
- Djursby, Malene, et al.
(författare)
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CDKN2A-mutation hos en familie med arveligt malignt melanom
- 2014
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Ingår i: Ugeskrift for Laeger. - 0041-5782. ; 176:40
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Tidskriftsartikel (refereegranskat)abstract
- Malignant melanoma (MM) is a frequent form of cancer with increasing incidence. 6-10% of patients with MM report a family history of MM, and in most populations 2% of unselected cases of MM carry a CDKN2A mutation. tvWe present a family with 24 cases of MM in nine persons from several generations, caused by a previously undescribed germ-line intronic mutation in CDKN2A. Through genetic counselling and genetic testing high-risk persons in the family are located and offered regular screening for MM.
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| 12. |
- Dyrberg, T., et al.
(författare)
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Patogenesen ved type 1 diabetes.
- 1989
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Ingår i: Ugeskrift for Laeger. - 0041-5782. ; 151:17, s. 1029-1030
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Tidskriftsartikel (refereegranskat)
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| 13. |
- Eriksen, K, et al.
(författare)
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Akut akalkulos kolecystit
- 1994
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 156:22, s. 3311-3314
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Tidskriftsartikel (refereegranskat)abstract
- Acute acalculous cholecystitis (AC) is an inflammatory process of the gallbladder, often caused by other severe diseases. The etiology is multifactorial, but the pathogenesis is in all cases a reduction in the gallbladder's emptying capacity. The mortality of AC reaches 85% without treatment. This fact makes it important to consider AC as a possible complication to major surgery, multi-trauma, and artificial ventilation. Symptoms resemble "normal" cholecystitis, but may be masked by the underlying severe disease. Fever without known focus may be the only symptom. Ultrasound, CT-scanning or cholangiography are used to verify the diagnosis, supplemented by laboratory investigations. Treatment is cholecystectomy. Percutaneous ultrasonic guided cholecystotomy is a good alternative if the diagnosis made in an early stage. The mortality is considerably reduced by early intervention.
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| 14. |
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| 15. |
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| 16. |
- Frisch, Morten, et al.
(författare)
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[Sexually transmitted infection as a cause of anal cancer]
- 1998
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Ingår i: Ugeskrift for læger. - 0041-5782 .- 1603-6824. ; 160:49, s. 7109-7117
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Tidskriftsartikel (refereegranskat)abstract
- Interviews were carried out with 423 women and 93 men with invasive or in situ anal cancer in Denmark and Sweden in a search for clues to the aetiology of this neoplasm. Patients with rectal adenocarcinoma (n = 534) and persons drawn from the background population (n = 554) served as controls. Multivariate logistic regression analyses confirmed previous observations of a strong association between either male homosexual experience or a history of anogenital warts and the risk for anal cancer. Moreover, hitherto unknown, but strong and consistent associations were observed between measures of high heterosexual activity and the risk for anal cancer among both sexes. Polymerase chain reaction analysis revealed human papilloma-virus DNA in the majority (88%) of anal cancer specimens but in none of 20 examined rectal adenocarcinomas. It is concluded that most anal cancers appear to be caused by sexually transmitted types of human papillomaviruses and, consequently, that anal cancer is a potentially preventable neoplasm.
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| 17. |
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| 18. |
- Grände, Per-Olof, et al.
(författare)
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Aktivt induceret hypotermi efter svaer traumatisk hjerneskade.
- 2010
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 172:19, s. 1437-1440
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Tidskriftsartikel (refereegranskat)abstract
- A Cochrane metaanalysis and a study performed on children have recently confirmed that therapeutic hypothermia does not improve outcome after severe traumatic brain injury (TBI). TBI is not comparable to a short episode of global ischemia, where therapeutic hypothermia has been shown to improve outcome. The difference may be explained by the fact that hypothermia-induced stress after a traumatic brain injury reduces cerebral perfusion in the penumbra zone, where local circulation is already reduced. Thus, to date there is no indication for therapeutic hypothermia in TBI patients.
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| 19. |
- Gustafsson, I., et al.
(författare)
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[Metabolic control by means of insulin in patients with type 2 diabetes and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity--secondary publication]
- 2006
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Ingår i: Ugeskr Laeger. - : Almindelige danske Lægeforening. - 1603-6824 .- 0041-5782. ; 168:6, s. 581-4
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Tidskriftsartikel (refereegranskat)abstract
- Patients with diabetes have an unfavourable prognosis after an acute myocardial infarction. The DIGAMI 2 study investigated the effect of various metabolic treatment strategies in type 2 diabetic patients with acute myocardial infarction: acutely introduced, long-term insulin treatment did not improve survival when compared with conventional management at similar levels of glucose control. However, good glucose control seems important since the glucose level was found to be a strong predictor of long-term mortality in this patient category.
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| 20. |
- Gøtze, Jens Peter, et al.
(författare)
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Ny markør ved trombotisk trombocytopenisk purpura
- 2008
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Ingår i: Ugeskrift for Laeger. - 0041-5782. ; 170:33, s. 9-2446
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Forskningsöversikt (refereegranskat)abstract
- Thrombotic microangiopathy can be caused by several conditions which are difficult to diagnose from the clinical presentation alone. Deficient enzyme activity of a newly-discovered enzyme, ADAMTS-13, can lead to thrombotic thrombocytopenic purpura (TTP). Lack of ADAMTS-13 activity causes increased concentrations of high molecular weight von Willebrand factor forms and increased platelet aggregation. Measurement of ADAMTS-13 activity is useful for the diagnosis of TTP and may also be relevant as a prognostic test for recurrent TTP.
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| 21. |
- Hansen, Soren, et al.
(författare)
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Benign paroksysmal positionel vertigo--den hyppigste form for otogen vertigo
- 2007
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 169:21, s. 1996-2002
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Tidskriftsartikel (refereegranskat)abstract
- Benign paroxysmal positional vertigo presents with brief, episodic, positioning-provoked vertigo and characteristic findings on Dix-Hallpike and other positional tests. This article is based on a systematic review of the literature and describes epidemiology, etiology, pathogenesis, diagnostic positional tests and treatment using canalith repositioning, liberatory and 360 degrees rotation manoeuvres. Diagnostic pitfalls, mastoid vibration, postmanoeuvre activity restriction and the ideal number of repositioning manoeuvres per treatment session are discussed.
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| 22. |
- Håkansson, Anders, et al.
(författare)
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Forskningstræning for alle læger - også uden for universitetssygehusene
- 2003
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 165:36, s. 3423-3423
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: General practitioners are often interested in doing research but are hampered by lack of time and research training. Interpreting the results of others can also be difficult. For this reason a course in basic research methods for GPs was started in Sweden in 1989. It was originally aimed at GPs but was later extended to hospital physicians as well. The course is given regionally and at present is held in six different locations in southern Sweden as well as in Hillerod, Denmark. The aim of this study is to evaluate the course as part of a research project to recommend changes to the courses in accordance with the course evaluations. MATERIALS AND METHODS: The course consists of theory (lectures/seminars six hours a month) and practice (project work) over a period of 18 months. Questionnaires were mailed to the 112 physicians who, starting in 1997 and 1999, completed the course. Eighty-five percent responded to the questionnaire, which asked if the course goals were relevant and if they thought they had achieved them. RESULTS: The most frequent reasons given for attending the course were a desire to learn how to read scientific articles critically and how to carry out one's own research projects. Two thirds of the participants thought that the theoretical lectures and project work had supplemented each other well. Most of the participants thought that the goals were very relevant but fewer--between 57% and 77%--felt those goals had been achieved. DISCUSSION: The course provides important empirical information with regard to future specialist training in Denmark. The plan is for all physicians to have research training--amounting to a total of 60 days--with lectures in research methodology and tutored research projects. The Danish College of General Practitioners has planned research training in accordance with the experience from these courses.
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| 23. |
- Ibrahim, Iman Badr, et al.
(författare)
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Reernæringssyndrom ved anorexia nervosa
- 2018
-
Ingår i: Ugeskrift for læger. - 0041-5782 .- 1603-6824. ; 180:18
-
Tidskriftsartikel (refereegranskat)abstract
- The refeeding syndrome (RFS) is a potentially fatal condition involving fluid and electrolyte imbalances after refeeding in patients with anorexia nervosa. Low-calorie diet added thiamine and minerals is the standard approach to prevent RFS. In a recent systematic review starting with a higher calorie amount than earlier has been recommended, and in another review, it is proposed that a restriction in the amount of carbohydrates may allow for a higher calorie intake early on to enable a safe and faster weight gain. There are still many unanswered questions, but these studies may point to a future change in the guidelines.
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| 24. |
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| 25. |
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| 26. |
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| 27. |
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| 28. |
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| 29. |
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| 30. |
- Kornø, Maj Raundrup, et al.
(författare)
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Behandling af Dupuytrens kontraktur
- 2015
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Ingår i: Ugeskrift for Laeger. - 0041-5782. ; 177:24, s. 2-6
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Dupuytren's disease is a hereditary fibroproliferative disease commonly affecting the palmar fascia of the hand, which results in progressive and irreversibly fixed flexion contractures of the hand. It may occur in the sole of the foot or in the penis. Generally, treatment has been up against a high frequency of complications and recurrence, but promising results are reported from less invasive treatment options, e.g. needle fasciotomy and enzymatic fasciotomy with collagenase. This is a detailed, comparative review of available non-operative and surgical treatments with focus on the enzymatic fasciotomy.
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| 31. |
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| 32. |
- Laustsen, Søren Ravn, et al.
(författare)
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Præoperativ funktionel magnetisk resonans-billeddannelse hos patienter med hjernetumor
- 2010
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Ingår i: Ugeskrift for læger. - 0041-5782 .- 1603-6824. ; 172:35, s. 2370-2376
-
Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Functional Magnetic Resonance Imaging (fMRI) allows important functions in the brain cortex to be mapped noninvasively. The purpose with this work was to investigate a possible correlation between the distance from the tumour margin to fMRI activity and postoperative neurological deficits by means of a standardised method for measurement of distance. A second purpose was to investigate the influence of preoperative fMRI on the neurosurgical decision-making process. MATERIAL AND METHODS: Retrospective study of 25 patients. The inclusion criteria were surgery or biopsy after fMRI plus a three-month postoperative assessment. A total of 14 patients complied with these requirements (six men and eight women, the mean age was 39 years). fMRI raw data was collected using a three tesla magnetic resonance scanner (Signa HDx R14M5, GE Healthcare). The distance from the tumour margin to fMRI activation was measured using GE-reformat version 4.2 after raw data had been postprocessed using GE BrainwavePA version 1.3.08130. The neurosurgeons valuation of fMRI in the preoperative decision-making process was obtained using a standard questionnaire. RESULTS: There was a trend of association between distance from tumour to eloquent functional areas and the patients' postoperative neurological outcome (Fisher's exact test: distance < 15 mm, p = 0.43; distance < 10 mm, p = 0.14). fMRI proved very useful when deciding whether to operate or not (42%), when deciding the surgical approach (50%) and when deciding the extent of the surgical approach (83%). CONCLUSION: The standardised method for measurement of distance between tumour margin and fMRI activity can contribute to the preoperative risk assessment in patients with brain tumours.
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| 33. |
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| 34. |
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| 35. |
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| 36. |
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| 37. |
- Nielsen, Jens, et al.
(författare)
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Health consequences of armed conflict in Guinea-Bissau
- 2010
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Ingår i: Ugeskrift for Laeger. - 0041-5782. ; 172:2, s. 132-136
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Forskningsöversikt (refereegranskat)abstract
- The present paper reviews studies carried out by the Bandim Health Project during the armed conflict in Guinea-Bissau, 1998-1999. Common health interventions like vaccination and breastfeeding, as well as focused interventions such as nutrition interventions aimed at malnourished children are effective measures. Population-based studies of health status gives important information about health conditions for groups at special risk, and provides information about which interventions are the most effective in an emergency.
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| 38. |
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| 39. |
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| 40. |
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| 41. |
- Petersen, Gry Kambskard, et al.
(författare)
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Refleksdystrofi
- 2002
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 164:43, s. 5019-5024
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Tidskriftsartikel (refereegranskat)abstract
- Reflex sympathetic dystrophy or complex regional pain syndrome type I is primarily a clinical diagnosis. The syndrome is most common after soft tissue damage or fractures and is more often seen in women than in men. The paramount symptom is pain, but oedema, a limited range of motion, changes in sensibility, and trophic changes are also seen. The pathogenesis is unknown, but most clinicians believe it to be caused by disturbances in the sympathetic or sensory nervous system and/or an excessive inflammatory response, most likely neurogenic inflammation. It seems that early treatment with physiotherapy and corticosteroids has a positive effect on the disease. Despite lack of documentation, the principles of treatment usually prescribed for the treatment of neurogenic pain must be taken into consideration. There is a lack of large double-blind studies on all aspects of the syndrome.
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| 42. |
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| 43. |
- Poulsen, S, et al.
(författare)
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Tuberkuloseudviklingen i Danmark 1972-1996
- 1999
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 161:23, s. 3452-3457
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Tidskriftsartikel (refereegranskat)abstract
- The present study is based on notified cases of tuberculosis (TB) in the National tbc. register 1972-1996. A decline in Tb incidence was seen from 1972 and until the mid-1980's. Subsequently the trend has reversed due to an increasing number of TB cases in foreigners. In 1996, 60% of all cases of TB in Denmark were found in foreigners reflecting the rising number of refugees and their families arriving in Denmark from highly endemic areas, mainly Somalia. Among native Danes the TB incidence fell from 14 per 100,000 in 1972 to 4 per 100,000 in the 1980's and stabilized at this very low level. The unchanged incidence in Danes covers a falling incidence in the older and a rising incidence in the younger and middle-aged adult population, mainly in the capital. Approximately half of the cases occur in high-risk groups. The TB-epidemic is close to elimination in the indigenous Danish population, but the disease is maintained at a low level probably due to increased patient and doctor delay and resulting microepidemics primarily in high-risk populations.
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| 44. |
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| 45. |
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| 46. |
- Reinstrup, Peter, et al.
(författare)
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Lav-flow-anaestesisystemer
- 1992
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 154:50, s. 3577-3579
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Tidskriftsartikel (refereegranskat)abstract
- At present, when economy and environment receive high priority, the ideal anaesthesia system with inhalation anaesthetics is a closed circle system in which only the gases which the patient consumes or produces are replaced or eliminated. Low-flow (LF) anaesthesia in which the fresh gas flow which is employed in a closed system, provides a stable system compares with closed anaesthesia systems. Compared with open systems and circler systems with considerable fresh gas flow, the LF system provides advantages as regards economy, environment and exposure of staff to inhalation anaesthetics. The special conditions involved in LF anaesthesia are described in detail with the hope that the method will obtain more widespread distribution than is the case in Denmark today. If greater safety under anaesthesia is desired, eg by monitoring the concentrations of CO2, O2 and inhalation anaesthetics which the patients inspire and expire, this monitoring equipment can be financed by introduction of LF anaesthesia.
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| 47. |
- Reinstrup, Peter, et al.
(författare)
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Lukkede anaestesisystemer
- 1992
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 154:50, s. 3573-3576
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Tidskriftsartikel (refereegranskat)abstract
- Anaesthesia with closed anaesthetic systems demands knowledge of the physiology of the patients and of how the various anaesthetic gases behave in the organism as only the gases which the patients produces and absorbs are eliminated and replaced. The system is educational as it provides knowledge of the genuine absorption of oxygen and anaesthetic gases. The method is favourable to the environment as only the gases which are used are supplied and it is thus economical in use although investment in monitoring equipment is necessary. In practice, induction and waking of the patient are complicated with this system and it requires an anaesthetist who constantly adjusts the gases in the circuit.
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| 48. |
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| 49. |
- Skov, Karin, et al.
(författare)
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Det nordiske nyreudvekslingsprogram
- 2020
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Ingår i: Ugeskrift for Læger. - 0041-5782. ; 182
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 50. |
- Skov, Karin, et al.
(författare)
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Det nordiske nyreudvekslingsprogram
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Ingår i: Ugeskrift for Læger. - 1603-6824 .- 0041-5782. ; , s. 1-6
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Tidskriftsartikel (refereegranskat)abstract
- This review describes the ScandiaTransplant Kidney Exchange Programme and the background of renal exchange programmes gaining popularity worldwide, possibilities and limitations of the programmes, the ethical aspects and perspectives. The first kidney exchanges between Danish and Swedish countries were performed in 2019, and until now 23 exchanges and transplantations have been performed. All surgical procedures have been performed simultaneously and/or coordinated at different hospitals in Scandinavia, and the kidney grafts were transported between the participating units
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