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| 2. |
- Rask-Andersen, Helge, et al.
(författare)
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Ganglion Cell and 'Dendrite' Populations in Electric Acoustic Stimulation Ears
- 2010
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Ingår i: Advances in Oto-Rhino-Laryngology. - : S. Karger AG. - 0065-3071 .- 1662-2847. ; 67, s. 14-27
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Tidskriftsartikel (refereegranskat)abstract
- Background/Aims: The electric acoustic stimulation (EAS) technique combines electric and acoustic stimulation in the same ear and utilizes both low-frequency acoustic hearing and electric stimulation of preserved neurons. We present data of ganglion cell and dendrite populations in ears from normal individuals and those suffering from adult-onset hereditary progressive hearing loss with various degrees of residual low-frequency hearing. Some of these were potential candidates for EAS surgery. The data may give us information about the neuroanatomic situation in EAS ears. Methods: Dendrites and ganglion cells were calculated and audiocytocochleograms constructed. The temporal bones were from the collection at the House Ear Institute in Los Angeles, Calif., USA. Normal human anatomy, based on surgical specimens, is presented. Results: Inner and outer hair cells, supporting cells, ganglion cells and dendrites were preserved in the apical region. In the mid-frequency region, around 1 kHz, the organ of Corti with inner and outer hair cells was often conserved while in the lower basal turn, representing frequencies above 3 kHz, the organ of Corti was atrophic and replaced by thin cells. Despite loss of hair cells and lamina fibers ganglion cells were present even after 28 years of deafness. Conclusions: Conditions with profound sensorineural hearing loss and preserved low-frequency hearing may have several causes and the pathology may vary accordingly. In our patients with progressive adult-onset sensorineural hearing loss (amalgamated into 'presbyacusis'), neurons were conserved even after long duration of deafness. These spiral ganglion cells may be excellent targets for electric stimulationusing the EAS technique.
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| 3. |
- Thurfjell, Niklas, et al.
(författare)
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Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck.
- 2005
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Ingår i: Advances in Oto-Rhino-Laryngology. - Basel : KARGER. - 0065-3071 .- 1662-2847. ; 62, s. 49-57
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND/AIMS: Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53. METHODS: To understand the function and importance of p63 in oral mucosa and tumour development we have studied protein as well as mRNA expression in normal oral mucosa and tumours. RESULTS/CONCLUSION: Expression of p63 proteins differs between the cell layers in normal oral mucosa, and primary HNSCC has a high expression level of p63 isoforms normally expressed in basal cells. Data suggest that p63 expression in HNSCC influences tumour cell differentiation.
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| 5. |
- Ödkvist, Lars, et al.
(författare)
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On the mechanisms of vestibular disturbancies caused by industrial solvents
- 1979
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Ingår i: Advances in Oto-Rhino-Laryngology. - : S. Karger. - 0065-3071 .- 1662-2847. ; 25, s. 167-172
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Tidskriftsartikel (refereegranskat)abstract
- The industrial solvents xylene, styrene, trichloroethylene and methylchloroform administered to rabbits caused a positional nystagmus and disturbances in the nystagmus response to rotatory acceleration. The positional nystagmus had a beat direction the opposite to positional alcohol nystagmus, which was in similar experiments elicited by methanol, ethanol and propanol. The three alcohols needed a ten times higher blood concentration to cause a nystagmus than the solvents did.
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| 6. |
- Ha, Patrick K, et al.
(författare)
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Molecular Pathology and Biomarkers.
- 2016
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Ingår i: Advances in oto-rhino-laryngology. - : S. Karger AG. - 1662-2847. ; 78, s. 17-24
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Tidskriftsartikel (refereegranskat)abstract
- The field of salivary gland tumor biology is quite broad, given the numerous subtypes of both benign and malignant tumors originating from the major and minor salivary glands. Knowledge about the molecular pathology of these lesions is still limited, and there are few clinically useful diagnostic and prognostic biomarkers. However, recent discoveries of certain key genomic alterations, such as chromosome translocations, copy number alterations, and mutations, provide new insights into the molecular pathogenesis of these lesions and may help to better define them. It is also hoped that this new knowledge can help to guide therapy, but this translation has been somewhat slow to develop, perhaps due to the rarity of these tumors and the lack of large, randomized studies. However, because of the limitations inherent in what surgery and radiation can provide, there is an urgent need for understanding of the mechanisms of carcinogenesis in these tumors individually, so that chemotherapy and/or targeted therapy can be rationally selected.
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| 8. |
- Håkansson, Bo, 1953
(författare)
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The future of bone conduction hearing devices
- 2011
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Ingår i: Advances in Oto-Rhino-Laryngology. - : S. Karger AG. - 0065-3071. - 9783805596992 ; 71, s. 140-152
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Tidskriftsartikel (refereegranskat)abstract
- The bone-anchored hearing aid (Baha) is today an important rehabilitation alternative for patients with mixed and conductive hearing loss and where air conduction devices should not or cannot be used. Some patients with single-sided deafness are also successfully treated with a Baha. Despite successful treatment of these patient groups, there is always a need for future improvements. First, it is well known that Baha are associated with some drawbacks related to skin infections, accidental or spontaneous loss of the bone implant, and patient refusal for treatment due to stigma. Therefore, in this chapter some alternatives to the Baha which have the potential to reduce these drawbacks are generally discussed. They all have the common feature that they do not need a permanent skin penetration. The alternatives to the Baha are: (1) improved conventional bone conduction (BC) devices, (2) devices with an implanted transducer referred to as BC implants (BCI), (3) dental-attached devices. Disregarding skin complication issues, direct BC devices like the Baha, have a superior advantage of better sound quality in the high-frequency range. How these devices might be improved in the future is also discussed. Finally, some recent advances in the development of a new BCI system will be presented, where the implanted transducer uses a non-screw attachment to a hollow recess of the temporal bone. Some preclinical studies have been performed showing that a BCI system can provide similar or higher output as compared with a Baha.
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| 9. |
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| 10. |
- Mudry, Albert, et al.
(författare)
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Historical background of bone conduction hearing devices and bone conduction hearing aids.
- 2011
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Ingår i: Advances in oto-rhino-laryngology. - : S. Karger AG. - 0065-3071. ; 71, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- During the last 20 years, bone-anchored hearing aids (Baha(®)) became a familiar solution in the treatment of some types of hearing loss. The aim of this chapter is to present the different historical steps which have permitted the production of this new bone conduction hearing device. The recognition of bone conduction hearing is old and was known at least in Antiquity. During the Renaissance, Girolamo Cardano demonstrated a method by which sound may be transmitted to the ear by means of a rod or the shaft of a spear held between one's teeth: this was the beginning of teeth stimulators to improve hearing, firstly in connection with a musical instrument and then, in the second part of the 19th century, with the speaker. The development of the carbon microphone at the beginning of the 20th century allowed the construction of the bone conduction vibrator placed on the mastoid area, notably supported by eyeglasses since the 1950s. Confronted by various problems, and notably the loss of part of sound in the soft tissue of the external mastoid, the idea to implant the vibrator into the mastoid bone was developed in Göteborg, and the first Baha was implanted in 1977 by Anders Tjellström. From that date, various improvements allowed the development of the actual Baha. These different steps are presented in this study, supported by original documentation.
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