| 1. |
- von Mecklenburg, Claes, et al.
(författare)
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Ultrastructural cerebrovascular changes in a model of subarachnoid hemorrhage in baboon based on triple cisternal blood injection
- 1990
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Ingår i: Surgical Neurology. - 0090-3019. ; 33:3, s. 195-201
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Tidskriftsartikel (refereegranskat)abstract
- In a subarachnoid hemorrhage model in the baboon, achieved through three cisternal blood injections with 1-day intervals, the cerebral arteries were dissected out 7 days after the first blood injection for electron microscopy All the animals showed ultrastructural changes in the cerebral arteries: two with severe, one with moderate, and three with mild alterations in the vessel walls. The most constant findings were seen in the muscle cells of the media layer. Fragmentation of the nuclei was frequently observed together with cytoplasmic vacuoles. Scattered groups or single degenerated muscle cells were also noted. In the intima the changes included rounding of the nuclei along with the appearance of cytoplasmic vacuoles. Desquamation or flattening of the endothelium and loss of tight junctions were encountered in some vessel areas. Degenerating mitochondria were a common finding.
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| 2. |
- Larson, DA, et al.
(författare)
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Radiosurgery patterns of practice
- 1995
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Ingår i: Surgical neurology. - : Elsevier BV. - 0090-3019. ; 44:5, s. 414-419
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Tidskriftsartikel (refereegranskat)
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| 3. |
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| 4. |
- Backlund, E.-O.
(författare)
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Commentary
- 2004
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Ingår i: Surgical Neurology. - : Elsevier BV. - 0090-3019 .- 1879-3339. ; 61:6, s. 540-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
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| 6. |
- Figaji, Anthony A., et al.
(författare)
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Transcranial Doppler pulsatility index is not a reliable indicator of intracranial pressure in children with severe traumatic brain injury
- 2009
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Ingår i: Surgical Neurology. - : Elsevier BV. - 0090-3019. ; 72:4, s. 389-394
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Tidskriftsartikel (refereegranskat)abstract
- Background: The TCD-derived PI has been associated with ICP in adult studies but has not been well investigated in children. We examined the relationship between PI and ICP and CPP in children with severe TBI. Methods: Data were prospectively collected from consecutive TCD studies in children with severe TBI undergoing ICP monitoring. Ipsilateral ICP and CPP values were examined with Spearman correlation coefficient (mean values and raw observations), with a GEE, and as binary values (1 and 20 mm Hg, respectively). Results: Thirty-four children underwent 275 TCD studies. There was a weak relationship between mean values of ICP and PI (P = .04, r = 0.36), but not when raw observations (P = .54) or GEE (P = .23) were used. Pulsatility index was 0.76 when ICP was lower than 20 mm Hg and 0.86 when ICP was 20 mm Hg or higher. When PI was 1 or higher, ICP was lower than 20 mm Hg in 62.5% (25 of 40 studies), and when ICP was 20 mm Hg or higher, PI was lower than 1 in 75% (46 of 61 studies). The sensitivity and specificity of a PI threshold of 1 for examining the ICP threshold of 20 mm Hg were 25% and 88%, respectively. The relationship between CPP and PI was stronger (P = .001, r -0.41), but there were too few observations below 50 mm Hg to examine PI at this threshold. Conclusion: The absolute value of the PI is not a reliable noninvasive indicator of ICP in children with severe TBI. Further study is required to examine the relationship between PI and a CPP threshold of 50 mm Hg. (C) 2009 Elsevier Inc. All rights reserved.
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| 7. |
- Herou, Erik, et al.
(författare)
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Acute Traumatic Brain Injury Mortality in the elderly.
- 2015
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Ingår i: Surgical Neurology. - : Elsevier BV. - 0090-3019. ; 83:6, s. 996-1001
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Tidskriftsartikel (refereegranskat)abstract
- Despite recent progress, prognosis for the elderly (defined as aged 70 or more) afflicted by Traumatic Brain Injury (TBI) is unfavorable and surgical intervention remains controversial. Research during the last decade on the mortality rates or prognostic factors for survival in the elderly is limited.
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| 8. |
- Holtz, A, et al.
(författare)
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Spinal cord blood flow measured by 14C-iodoantipyrine autoradiography during and after graded spinal cord compression in rats.
- 1989
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Ingår i: Surgical Neurology. - 0090-3019 .- 1879-3339. ; 31:5, s. 350-60
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Tidskriftsartikel (refereegranskat)abstract
- The relations between degree of thoracic spinal cord compression causing myelographic block, reversible paraparesis, and extinction of the sensory evoked potential on one hand, and spinal cord blood flow on the other, were investigated. This was done in rats using the blocking weight-technique and 14C-iodoantipyrine autoradiography. A load of 9 g caused myelographic block. Five minutes of compression with that load caused a reduction of spinal cord blood flow to about 25%, but 5 and 60 minutes after the compression spinal cord blood flow was restored to 60% of the pretrauma value. A load of 35 g for 5 minutes caused transient paraparesis. Recovery to about 30% was observed 5 and 60 minutes thereafter. During compression at a load of 55 g, which caused almost total extinction of sensory evoked potential and irreversible paraplegia, spinal cord blood flow under the load ceased. The results indicate that myelographic block occurs at a load which does not cause irreversible paraparesis and that a load which permits sensory evoked potential to be elicited results in potentially salvageable damage.
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