| 1. |
- Barragan, A, et al.
(författare)
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Transepithelial migration by Toxoplasma
- 2008
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Ingår i: Sub-cellular biochemistry. - New York, NY : Springer New York. - 0306-0225. ; 47, s. 198-207
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
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| 4. |
- Gensous, N, et al.
(författare)
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Down Syndrome, Ageing and Epigenetics
- 2019
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Ingår i: Sub-cellular biochemistry. - Singapore : Springer Singapore. - 0306-0225. ; 91, s. 161-193
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Tidskriftsartikel (refereegranskat)
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| 5. |
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| 6. |
- Lindås, Ann-Christin, et al.
(författare)
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Archaeal Actin-Family Filament Systems.
- 2017
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Ingår i: Sub-cellular biochemistry. - Cham : Springer International Publishing. - 0306-0225. ; 84, s. 379-392
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Tidskriftsartikel (refereegranskat)abstract
- Actin represents one of the most abundant and conserved eukaryotic proteins over time, and has an important role in many different cellular processes such as cell shape determination, motility, force generation, cytokinesis, amongst many others. Eukaryotic actin has been studied for decades and was for a long time considered a eukaryote-specific trait. However, in the early 2000s a bacterial actin homolog, MreB, was identified, characterized and found to have a cytoskeletal function and group within the superfamily of actin proteins. More recently, an actin cytoskeleton was also identified in archaea. The genome of the hyperthermophilic crenarchaeon Pyrobaculum calidifontis contains a five-gene cluster named Arcade encoding for an actin homolog, Crenactin, polymerizing into helical filaments spanning the whole length of the cell. Phylogenetic and structural studies place Crenactin closer to the eukaryotic actin than to the bacterial homologues. A significant difference, however, is that Crenactin can form single helical filaments in addition to filaments containing two intertwined proto filaments. The genome of the recently discovered Lokiarchaeota encodes several different actin homologues, termed Lokiactins, which are even more closely related to the eukaryotic actin than Crenactin. A primitive, dynamic actin-based cytoskeleton in archaea could have enabled the engulfment of the alphaproteobacterial progenitor of the mitochondria, a key-event in the evolution of eukaryotes.
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| 7. |
- Mas, G., et al.
(författare)
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The Periplasmic Chaperones Skp and SurA
- 2019
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Ingår i: Bacterial Cell Walls and Membranes. - Cham : Springer International Publishing. - 0306-0225.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The periplasm of Gram-negative bacteria contains a specialized chaperone network that facilitates the transport of unfolded membrane proteins to the outer membrane as its primary functional role. The network, involving the chaperones Skp and SurA as key players and potentially additional chaperones, is indispensable for the survival of the cell. Structural descriptions of the apo forms of these molecular chaperones were initially provided by X-ray crystallography. Subsequently, a combination of experimental biophysical methods including solution NMR spectroscopy provided a detailed understanding of full-length chaperone–client complexes. The data showed that conformational changes and dynamic re-organization of the chaperones upon client binding, as well as client dynamics on the chaperone surface are crucial for function. This chapter gives an overview of the structure-function relationship of the dynamic conformational rearrangements that regulate the functional cycles of the periplasmic molecular chaperones Skp and SurA. © 2019, Springer Nature Switzerland AG.
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| 8. |
- Rydberg, Lennart, 1944, et al.
(författare)
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alpha-Gal epitopes in animal tissue glycoproteins and glycolipids.
- 1999
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Ingår i: Sub-cellular biochemistry. - 0306-0225. ; 32, s. 107-25
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Tidskriftsartikel (refereegranskat)abstract
- alpha-Gal terminated saccharides are present on the cell surface both as glycolipids and glycoproteins in all mammals except Old World monkeys and humans. The structural diversity among identified saccharides terminated by this epitope in animal tissues is steadily increasing. The majority of these saccharides have the alpha-Gal linked to lactosamine but other core saccharides exist. The alpha-Gal terminated saccharides are recognized by the immune system as a specific antigen and antibodies directed to the alpha-Gal, which do not cross-react with the classic blood group B trisaccharide, are found in man and Old World monkeys. Similar to other complex carbohydrate cell surface antigens, the alpha-Gal epitope is heterogeneously distributed in different organs and in different cells within an organ. It is present on the vascular endothelium and it is the primary target for human naturally occurring antibodies following pig to primate/man xenotransplantation leading to hyperacute rejection of the graft. Important for the future will be to further structurally characterize this antigen system, its cellular/subcellular distribution, and to identify possible of additional glycosyltransferases, related to the already described alpha 1,3galactosyltransferase that may explain the structural diversity. Such information will be of importance in the studies of, for example, the pathogenesis of autoimmune diseases and for the production of genetically modified pigs to prevent xenograft rejection.
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| 9. |
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