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Sökning: L773:0743 7463 OR L773:1520 5827

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1.
  • Andersson, August, et al. (författare)
  • Magnetic resonance investigations of lipid motion in isotropic bicelles
  • 2005
  • Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 21:7, s. 7702-7709
  • Tidskriftsartikel (refereegranskat)abstract
    • The dynamics of DMPC in different isotropic bicelles have been investigated by NMR and EPR methods. The local dynamics were obtained by interpretation of 13C NMR relaxation measurements of DMPC in the bicelles, and these results were compared to EPR spectra of spin-labeled lipids. The overall size of the bicelles was investigated by PFG NMR translational diffusion measurements. The dynamics and relative sizes were compared among three different bicelles: [DMPC]/[DHPC] = 0.25, [DMPC]/[DHPC] = 0.5, and [DMPC]/[CHAPS] = 0.5. The local motion is found to depend much more strongly on the choice of the detergent, rather than the overall size of the bicelle. The results provide an explanation for differences in apparent dynamics for different peptides, which are bound to bicelles. This in turn determines under what conditions reasonable NMR spectra can be observed. A model is presented in which extensive local motion, in conjunction with the overall size, affects the spectral properties. An analytical expression for the size dependence of the bicelles, relating the radius of the bilayer region with physical properties of the detergent and the lipid, is also presented.
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2.
  • Allouche, Joachim, et al. (författare)
  • Simultaneous Conductivity and Viscosity Measurements as a Technique To Track Emulsion Inversion by the Phase-Inversion-Temperature Method
  • 2004
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 20:6, s. 2134-2140
  • Tidskriftsartikel (refereegranskat)abstract
    • Two kinds of transitions can occur when an emulsified water-oil-ethoxylated nonionic surfactant system is cooled under const. stirring. At a water-oil ratio close to unity, a transitional inversion takes place from a water-in-oil (W/O) to an oil-in-water (O/W) morphol. according to the so-called phase-inversion-temp. method. At a high water content, a multiple W/O/W emulsion changes to a simple O/W emulsion. The continuous monitoring of both the emulsion cond. and viscosity allows the identification of several phenomena that take place during the temp. decrease. In all cases, a viscosity max. is found on each side of the three-phase behavior temp. interval and correlates with the attainment of extremely fine emulsions, where the best compromise between a low-tension and a not-too-unstable emulsion is reached. The studied system contains Polysorbate 85, a light alkane cut oil, and a sodium chloride brine. All transitions are interpreted in the framework of the formulation-compn. bidimensional map.
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3.
  • Abele, S, et al. (författare)
  • Reactive surfactants in heterophase polymerization. 10. Characterization of the surface activity of new polymerizable surfactants derived from maleic anhydride
  • 1997
  • Ingår i: Langmuir. - 0743-7463 .- 1520-5827. ; 13, s. 176-181
  • Tidskriftsartikel (refereegranskat)abstract
    • Characterization of the surface activity of previously obtained polymerizable dialkyl maleates is performed to find out the relation between the structure of surfactants and their performances. The given polymerizable surfactants were synthesized for using in the emulsion polymerization. Three groups of dialkyl maleates-nonionic, cationic and zwitterionic-with different chain lengths of hydrophobic alkyl groups are investigated. Critical micelle concentration (cmc) values are determined for water soluble surfactants. It is found that cmc decreases with increasing chain length of the hydrophobic alkyl group. For nonionic and cationic surfactants interfacial tension at the interface between water and dodecane is measured. Droplet size in oil-in-water (O/W) emulsions is determined for all given surfactants. Cationic and zwitterionic dialkyl maleates with the longest investigated alkyl chain (R=C16H33, C17H35) provide good stability of O/W emulsions. In order to compare the obtained results, measurements with well-known surfactants-nonionic nonylphenol-poly(ethylene oxide) (NPEO10) and cationic hexadecyltrimethyl ammonium bromide (CTAB)-are performed.
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4.
  • Aben, Simon, et al. (författare)
  • Rheological Investigations on the Creaming of Depletion-Flocculated Emulsions
  • 2012
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 28:21, s. 7967-7975
  • Tidskriftsartikel (refereegranskat)abstract
    • Preventing creaming or sedimentation by the addition of thickeners is an important industrial challenge. We study the effect of the addition of a "free" nonadsorbing polymer (xanthan gum) on the stability against creaming of sterically stabilized O/W emulsions. Therefore, we analyze our samples using microscopy and rheological measurements. At low xanthan concentrations, the emulsions cream. However, above a certain concentration a three-dimensional network of droplets is formed, which can prevent creaming. We attribute the formation of this structure to depletion attraction. The rheological behavior of an emulsion that is macroscopically stable should be elastic, while it should be viscous for a creaming emulsion. In order to distinguish between stable and unstable samples, we measure their relaxation time by mechanical rheology and find a good correlation to the visual observation. However, the measured relaxation times are much shorter than the time-scales, on which we observe creaming. We hypothesize that the measured relaxation time is related to the droplet-droplet interaction. This determines the frequency at which microscopic rearrangements occur, which weaken the network structure prior to creaming. Based on this interpretation, the relaxation time gives direct access to the microstructural processes involved in creaming. We therefore suggest using it as a predictive parameter of creaming stability.
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5.
  • Abitbol, Tiffany, et al. (författare)
  • Surface Charge Influence on the Phase Separation and Viscosity of Cellulose Nanocrystals
  • 2018
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 34:13, s. 3925-3933
  • Tidskriftsartikel (refereegranskat)abstract
    • counterions in the suspensions. The results suggest that there is a threshold surface charge density (∼0.3%S) above which effective volume considerations are dominant across the concentration range relevant to liquid crystalline phase formation. Above this threshold value, phase separation occurs at the same effective volume fraction of CNCs (∼10 vol %), with a corresponding increase in critical concentration due to the decrease in effective diameter that occurs with increasing surface charge. Below or near this threshold value, the formation of end-to-end aggregates may favor gelation and interfere with ordered phase formation.
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6.
  • Abraham, T., et al. (författare)
  • Polyelectrolyte-mediated interaction between similarly charged surfaces : Role of divalent counter ions in tuning surface forces
  • 2001
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 17:26, s. 8321-8327
  • Tidskriftsartikel (refereegranskat)abstract
    • The effects of divalent salts (CaCl2, MgCl2 and BaCl2) in promoting the adsorption of weakly charged polyelectrolyte (polyacrylic acid), PAA, Mw similar to 250000 g/mol) on mica surfaces and their role in tuning the nature of interactions between such adsorbed polyelectrolyte layers were studied using the interferometric surface forces apparatus. With mica surfaces in 3 mM MgCl2 solutions at pH similar to8.0-9.0, the addition of 10 ppm PAA resulted in a long-range attractive bridging force and a short-range repulsive steric force. This force profile indicates a low surface coverage and weak adsorption. The range of the force can be related to the characteristic length scale R-G of polyelectrolyte chains using a scaling description. An increase of the PAA concentration to 50 ppm changed the attractive force profile to a monotonic, long-range repulsive interaction extending up to 600 Angstrom due to the increased surface coverage of polyelectrolyte chains on the mica surfaces. Comparison of the measured forces with a scaling mean field model suggests that the adsorbed polyelectrolyte chains are stretched, which eventually give rise to the polyelectrolyte brush like structure. When the mica surfaces were preincubated in 3 mM CaCl2 at pH similar to8.0-9.0, in contrast to the case of 3 MM MgCl2, the addition of 10 ppm PAA resulted in a more complex force profile: long-range repulsive forces extending up to 800 Angstrom followed by an attractive force regime and a second repulsive force regime at shorter separations. The long-range electrosteric forces can be attributed to strong adsorption of polyelectrolyte chains on mica surfaces (high surface coverage) which is facilitated by the presence of Ca2+ ions, while the intermediate range attractive forces can be ascribed to Ca2+ assisted bridging between adsorbed polyelectrolyte chains. Also interesting is to note various relaxation processes present in this system. In contrast to both MgCl2 and CaCl2 systems, with mica surfaces in 3 mM BaCl2 solution at pH similar to8.0-9.0, the addition of 10 ppm PAA resulted in precipitation of polyelectrolyte chains on mica surfaces, resulting in an extremely long-range monotonic repulsive force profile. In summary, our study showed that divalent counterions (Mg2+, Ca2+, and Ba2+) exhibit significantly different behavior in promoting PAA adsorption on mica surfaces, modifying and controlling various surface interactions.
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7.
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8.
  • Afifi, Hala, et al. (författare)
  • Solubilization of Oils or Addition of Monoglycerides Drives the Formation of Wormlike Micelles with an Elliptical Cross-Section in Cholesterol-Based Surfactants : A Study by Rheology, SANS, and Cryo-TEM
  • 2011
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 27:12, s. 7480-7492
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the formation of wormlike micelles (WLM) in poly(oxyethylene) cholesteryl ether (ChEO(10)) aqueous solutions by the addition of lipophilic monoglycerides at room temperature (monolaurin (ML), monocaprin (MC), and monocaprylin (MCL)) bearing 12-, 10-, and 8-carbon alkyl chains, respectively. A combination of rheology, small-angle neutron scattering (SANS), and cryo-TEM was used to study their viscoelastic properties and structure. With the successive addition of cosurfactant, a significant increase in viscosity and a clear solidlike behavior is obtained, suggesting the formation of a viscoelastic network of wormlike micelles. Only for MCL is typical Maxwellian behavior obtained. The onset of micellar growth, as detected by the occurrence of solidlike behavior and a significant increase in viscosity, is obtained for 0.30 (1 wt %), 0.34 (1 wt %), and 0.60 (1.5 wt %) cosurfactant/ChEO(10) molar ratios with ML, MC, and MCL, respectively. With ML and MC, extremely long relaxation times (exceeding 20 s) compared to those of MCL are obtained, and zero-shear viscosity values are more than 1 order of magnitude higher than with MCL. These results show that cosurfactants with longer alkyl chain lengths (ML and MC) induce the formation of longer wormlike micelles and do so at lower concentrations. SANS measurements on dilute solutions confirm that the viscoelastic behavior correlates with an increase in contour length and reveals an elliptical cross-section with an axial ratio of around 2. Cryo-TEM images provide visual evidence of the wormlike micelles and confirm the elliptical shape of the cross-section. The addition of small amounts of aliphatic oils (ethyl butyrate, EB, and ethyl caprylate, EC) and cyclic oils (peppermint, PP, and tea tree, TT, oils) to ChEO(10) solutions induces wormlike micelle formation at a lower cosurfactant concentration or even in its absence (for PP, TT, and EC) because of their probable localization in the palisade layer. The viscosity peak and height of the plateau modulus occur at increasing monoglyceride concentration following the order PP ≈ TT > EC > EB > no oil.
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9.
  • Aggarwal, N., et al. (författare)
  • Effect of Molecular Composition of Heparin and Cellulose Sulfate on Multilayer Formation and Cell Response
  • 2013
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 29:45, s. 13853-13864
  • Tidskriftsartikel (refereegranskat)abstract
    • Here, the layer-by-layer method was applied to assemble films from chitosan paired with either heparin or a semisynthetic cellulose sulfate (CS) that possessed a higher sulfation degree than heparin. Ion pairing was exploited during multilayer formation at pH 4, while hydrogen bonding is likely to occur at pH 9. Effects of polyanions and pH value during layer formation on multilayers properties were studied by surface plasmon resonance ("dry layer mass"), quartz crystal microbalance with dissipation monitoring ("wet layer mass"), water contact angle, and zeta potential measurements. Bioactivity of multilayers was studied regarding fibronectin adsorption and adhesion/proliferation of C2C12 myoblast cells. Layer growth and dry mass were higher for both polyanions at pH 4 when ion pairing occurred, while it decreased significantly with heparin at pH 9. By contrast, CS as polyanion resulted also in high layer growth and mass at pH 9, indicating a much stronger effect of hydrogen bonding between chitosan and CS. Water contact angle and zeta potential measurements indicated a more separated structure of multilayers from chitosan and heparin at pH 4, while CS led to a more fuzzy intermingled structure at both pH values. Cell behavior was highly dependent on pH during multilayer formation with heparin as polyanion and was closely related to fibronectin adsorption. By contrast, CS and chitosan did not show such dependency on pH value, where adhesion and growth of cells was high. Results of this study show that CS is an attractive candidate for multilayer formation that does not depend so strongly on pH during multilayer formation. In addition, such multilayer system also represents a good substrate for cell interactions despite the rather soft structure. As previous studies have shown specific interaction of CS with growth factors, multilayers from chitosan and CS may be of great interest for different biomedical applications.
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10.
  • Aggarwal, Ruchi, et al. (författare)
  • From Bulk Molybdenum Disulfide (MoS 2 ) to Suspensions of Exfoliated MoS 2 in an Aqueous Medium and Their Applications
  • 2024
  • Ingår i: Langmuir. - 1520-5827 .- 0743-7463. ; 40:19, s. 9855-9872
  • Forskningsöversikt (refereegranskat)abstract
    • Two-dimensional (2D) layered materials like graphene, transition-metal dichalcogenides (TMDs), boron nitrides, etc., exhibit unique and fascinating properties, such as high surface-to-volume ratio, inherent mechanical flexibility and robustness, tunable bandgap, and high carrier mobility, which makes them an apt candidate for flexible electronics with low consumption of power. Because of these properties, they are in tremendous demand for advancement in energy, environmental, and biomedical sectors developed through various technologies. The production and scalability of these materials must be sustainable and ecofriendly to utilize these unique properties in the real world. Here, in this current review, we review molybdenum disulfide (MoS2 nanosheets) in detail, focusing on exfoliated MoS2 in water and the applicability of aqueous MoS2 suspensions in various fields. The exfoliation of MoS2 results in the formation of single or few-layered MoS2. Therefore, this Review focuses on the few layers of exfoliated MoS2 that have the additional properties of 2D layered materials and higher excellent compatibility for integration than existing conventional Si tools. Hence, a few layers of exfoliated MoS2 are widely explored in biosensing, gas sensing, catalysis, photodetectors, energy storage devices, a light-emitting diode (LED), adsorption, etc. This review covers the numerous methodologies to exfoliate MoS2, focusing on the various published methodologies to obtain nanosheets of MoS2 from water solutions and their use.
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11.
  • Agmo Hernández, Víctor, et al. (författare)
  • Intrinsic Heterogeneity in Liposome Suspensions Caused by the Dynamic Spontaneous Formation of Hydrophobic Active Sites in Lipid Membranes
  • 2011
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 27:8, s. 4873-4883
  • Tidskriftsartikel (refereegranskat)abstract
    • The spontaneous, dynamic formation of hydrophobic active sites in lipid bilayer membranes is studied and characterized. It is shown that the rates of formation and consumption of these active sites control at least two important properties of liposomes: their affinity for hydrophobic surfaces and the rate by which they spontaneously release encapsulated molecules. The adhesion and spreading of liposomes onto hydrophobic polystyrene nanoparticles and the spontaneous leakage of an encapsulated fluorescent dye were monitored for different liposome compositions employing Cryo-TEM, DLS, and fluorescence measurements. It was observed that an apparently homogeneous, monodisperse liposome suspension behaves as if composed by two different populations: a fast leaking population that presents affinity for the hydrophobic substrate employed, and a slow leaking population that does not attach immediately to it. The results reported here suggest that the proportion of liposomes in each population changes over time until a dynamic equilibrium is reached. It is shown that this phenomenom can lead to irreproducibility in, for example, spontaneous leakage experiments, as extruded liposomes leak much faster just after preparation than 24 h afterward. Our findings account for discrepancies in several experimental results reported in the literature. To our knowledge, this is the first systematic study addressing the issue of an existing intrinsic heterogeneity of liposome suspensions.
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12.
  • Agthe, Michael, et al. (författare)
  • Controlling orientational and translational order of iron oxide nanocubes by assembly in nanofluidic containers
  • 2015
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 31:45, s. 12537-12543
  • Tidskriftsartikel (refereegranskat)abstract
    • We demonstrate that spatial confinement can be used to control the orientational and translational order of cubic nanoparticles. For this purpose we have combined X-ray scattering and scanning electron microscopy to study the ordering of iron oxide nanocubes that have self-assembled from toluene-based dispersions in nanofluidic channels. An analysis of scattering vector components with directions parallel and perpendicular to the slit walls shows that the confining walls induce a preferential parallel alignment of the nanocube (100) faces. Moreover, slit wall separations that are commensurate with an integer multiple of the edge length of the oleic acid-capped nanocubes result in a more pronounced translational order of the self-assembled arrays compared to incommensurate confinement. These results show that the confined assembly of anisotropic nanocrystals is a promising route to nanoscale devices with tunable anisotropic properties.
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13.
  • Agthe, Michael, et al. (författare)
  • Following the Assembly of Iron Oxide Nanocubes by Video Microscopy and Quartz Crystal Microbalance with Dissipation Monitoring
  • 2017
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 33:1, s. 303-310
  • Tidskriftsartikel (refereegranskat)abstract
    • We have studied the growth of ordered arrays by evaporation-induced self-assembly of iron oxide nanocubes with edge lengths of 6.8 and 10.1 nm using video microscopy (VM) and quartz crystal microbalance with dissipation monitoring (QCM-D). Ex situ electron diffraction of the ordered arrays demonstrates that the crystal axes of the nanocubes are coaligned and confirms that the ordered arrays are mesocrystals. Time-resolved video microscopy shows that growth of the highly ordered arrays at slow solvent evaporation is controlled by particle diffusion and can be described by a simple growth model. The growth of each mesocrystal depends only on the number of nanoparticles within the accessible region irrespective of the relative time of formation. The mass of the dried mesocrystals estimated from the analysis of the bandwidth-shift-to-frequency-shift ratio correlates well with the total mass of the oleate-coated nanoparticles in the deposited dispersion drop.
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14.
  • Ahrén, Maria, et al. (författare)
  • Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Enhancement
  • 2010
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 26:8, s. 5753-5762
  • Tidskriftsartikel (refereegranskat)abstract
    • Recently, much attention has been given to the development of biofunctionalized nanoparticles with magnetic properties for novel biomedical imaging. Guided, smart, targeting nanoparticulate magnetic resonance imaging (MRI) contrast agents inducing high MRI signal will be valuable tools for future tissue specific imaging and investigation of molecular and cellular events. In this study. We report a new design of functionalized ultrasmall rare earth based nanoparticles to be used as a positive contrast agent in NI RI. The relaxivity is compared to commercially available Gd based chelates. The synthesis, PEGylation, and dialysis of small (3-5 nm) gadolinium oxide (DEG-Gd2O3) nanoparticles are presented. The chemical and physical properties of the nanomaterial were investigated with Fourier transform infrared spectroscopy. X-ray photoelectron spectroscopy, transmission electron microscopy, and dynamic light scattering. Neutrophil activation after exposure to this nanomaterial was studied by means of fluorescence microscopy. The proton relaxation times as a function of dialysis time and functionalization were measured at 1.5 T. A capping procedure introducing stabilizing properties was designed and verified, and the dialysis effects were evaluated. A higher proton relaxivity was obtained for as-synthesized diethylene glycol (DEG)-Gd2O3 nanoparticles compared to commercial Gd-DTPA. A slight decrease of the relaxivity for as-synthesized DEG-Gd2O3 nanoparticles as a function of dialysis time was observed. The results for functionalized nanoparticles showed a considerable relaxivity increase for particles dialyzed extensively with r(1) and r(2) values approximately 4 times the corresponding values for Gd-DTPA. The microscopy study showed that PEGylated nanoparticles do not activate neutrophils in contrast to uncapped Gd2O3. Finally, the nanoparticles are equipped with Rhodamine to show that our PEGylated nanoparticles are available for further coupling chemistry, and thus prepared for targeting purposes. The long term goal is to design a powerful, directed contrast agent for MRI examinations with specific targeting possibilities and with properties inducing local contrast, that is. an extremely high MR signal at the cellular and molecular level.
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15.
  • Ahualli, S., et al. (författare)
  • Dynamic electrophoretic mobility of concentrated dispersions of spherical colloidal particles. On the consistent use of the cell model
  • 2006
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 22:16, s. 7041-7051
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper outlines a complete and self-consistent cell model theory of the electrokinetics of dense spherical colloidal suspensions for general electrolyte composition, frequency of applied field, ? potential, and particle size. The standard electrokinetic equations, first introduced for any given particle configuration, are made tractable to computation by averaging over particle configurations. The focus of this paper is on the systematic development of suitable boundary conditions at the outer cell boundary obtained from global constraints on the suspension. The approach is discussed in relation to previously published boundary conditions that have often been introduced in an ad hoc manner. Results of a robust numerical calculation of high-frequency colloidal transport properties, such as dynamic mobility, using the present model are presented and compared with some existing dense suspension models. © 2006 American Chemical Society.
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16.
  • Ainalem, Marie-Louise, et al. (författare)
  • DNA Binding to Zwitterionic Model Membranes
  • 2010
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 26:7, s. 4965-4976
  • Tidskriftsartikel (refereegranskat)abstract
    • This study shows that DNA (linearized plasmid, 4331 base pairs and salmon sperm, 2000 base pairs, respectively) adsorbs to model membranes of zwitterionic liquid crystalline phospholipid bilayers in solutions containing divalent Ca2+ rations, and also in solutions containing monovalent Na+. The interaction between DNA and surface-supported model membranes was followed in situ using null ellipsometry, quartz crystal microbalance with dissipation, as well as neutron reflectometry. In the presence of Na+ (in the absence Of multivalent ions), DNA adopts an extended coil conformation upon adsorption. The solvent content in the adsorbed layer is high, and DNA is positioned on top of the membrane. In the presence of divalent Ca2+. the driving force for the adsorption of DNA is electrostatic, and the adsorbed DNA film is not as dilute its in a solution containing Na+. Cryo-TEM and SANS were further used to investigate the interaction in bulk solution using vesicles as model membrane systems. DNA adsorption could not be identified in the presence of Na+ using SANS, but cryo-TEM indicates the presence of DNA between neighboring unilamellar vesicles. In the presence of Ca2+. DNA induces the formation of multilamellar vesicles in which DNA intercalates the lamellae. Possible electrostatic and hydrophobic mechanisms for the adsorption of DNA in solutions containing monovalent salt are discussed and compared to the observations in divalent salt.
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17.
  • Ainalem, Marie-Louise, et al. (författare)
  • Interactions between DNA and Poly(amido amine) Dendrimers on Silica Surfaces.
  • 2010
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 26:11, s. 8625-8635
  • Tidskriftsartikel (refereegranskat)abstract
    • This study increases the understanding at a molecular level of the interactions between DNA and poly(amido amine) (PAMAM) dendrimers on solid surfaces, which is a subject of potential interest in applications such as gene therapy. We have used in situ null ellipsometry and neutron reflectometry to study the structure of multilayer arrangements formed by PAMAM dendrimers of generation 2 (G2), 4 (G4), and 6 (G6) and DNA on silica surfaces. Specifically, we adsorbed cationic dendrimer layers, then we condensed DNA to form dendrimer-DNA bilayers, and last we exposed further dendrimer molecules to the interface to encapsulate DNA in dendrimer-DNA-dendrimer trilayers. The dendrimer monolayers formed initially result in the deformation of the cationic adsorbates as a result of their strong electrostatic attraction to the hydrophilic silica surface. The highest surface excess and most pronounced deformation occurs for the G6 molecules due to their relatively large size and high surface charge density. G6-functionalized surfaces give rise to the highest surface excess of DNA during the bilayer formation process. This result is explained in terms of the high number of charged binding sites in the G6 monolayer and the low electrostatic repulsion between DNA and exposed patches of silica surface due to the relatively thick G6 monolayer. The binding strengths of the silica-dendrimer and dendrimer-DNA interactions are demonstrated by the high stability of the interfacial bilayers during rinsing. For the formation of trilayers of dendrimers, DNA, and dendrimers, G2 adsorbs as a smooth layer while G4 and G6 induce the formation of less well-defined structures due to more complex DNA layer morphologies.
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18.
  • Akinchina, Anna, et al. (författare)
  • Diblock polyampholytes grafted onto spherical particles: Effect of stiffness, charge density, and grafting density
  • 2007
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 23:3, s. 1465-1472
  • Tidskriftsartikel (refereegranskat)abstract
    • The structure of spherical brushes formed by symmetric diblock polyampholytes end-grafted onto small spherical particles in aqueous solution is examined within the framework of the so-called primitive model using Monte Carlo simulations. The properties of the two blocks are identical except for the sign of their charges. Three different chain flexibilities corresponding to flexible, semiflexible, and stiff blocks are considered at various polyampholyte linear charge densities and grafting densities. The link between the two blocks is flexible at all conditions, and the grafted segments are laterally mobile. Radial and lateral spatial distribution functions of different types and single-chain properties are analyzed. The brush structure strongly depends on the chain flexibility. With flexible chains, a disordered polyelectrolyte complex is formed at the surface of the particle, the complex becoming more compact at increasing linear charge density. With stiff blocks, the inner blocks are radially oriented. At low linear charged density, the outer blocks are orientationally disordered, whereas at increasing electrostatic interaction the two blocks of a polyampholyte are parallel and close to each other, leading to an ordered structure referred to as a polyampholyte star. As the grafting density is increased, the brush thickness responds differently for flexible and nonflexible chains, depending on a different balance between electrostatic interactions and excluded volume effects.
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19.
  • Akinchina, Anna, et al. (författare)
  • Diblock polyampholytes grafted onto spherical particles: Monte Carlo simulation and lattice mean-field theory
  • 2004
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 20:23, s. 10351-10360
  • Tidskriftsartikel (refereegranskat)abstract
    • Spherical brushes composed of diblock polyampholytes (diblock copolymers with oppositely charged blocks) grafted onto solid spherical particles in aqueous solution are investigated by using the primitive model solved with Monte Carlo simulations and by lattice mean-field theory. Polyampholyte chains of two compositions are considered: a copolymer with a long and a short block, A(100)B(10), and a copolymer with two blocks of equal length, A(50)B(50). The B block is end-grafted onto the surface, and its charge is varied, whereas the charge of the A block is fixed. Single-chain properties, radial and lateral spatial distributions of different types, and structure factors are analyzed. The brush structure strongly depends on the charge of the B block. In the limit of an uncharged B block, the chains are stretched and form an extended polyelectrolyte brush. In the other limit with the charges of the blocks compensating each other, the chains are collapsed and form a polyelectrolyte complex surrounding the particles. At intermediate charge conditions, a polyelectrolyte brush and a polyelectrolyte complex coexist and constitute two substructures of the spherical brush. The differences of the brush structures formed by the A(100)B(10) and A(50)B(50) polyampholytes are also analyzed. Finally, a comparison of the predictions of the two theoretical approaches is made.
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20.
  • Al-Bataineh, Sameer A., et al. (författare)
  • Covalent Immobilization of Antibacterial Furanones via Photochemical Activation of Perfluorophenylazide
  • 2009
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 25:13, s. 7432-7437
  • Tidskriftsartikel (refereegranskat)abstract
    • N-(3-Trimethoxysilylpropyl)-4-azido-2,3,5,6-tetrafluorobenzamide (PFPA-silane) was used as a photoactive crosslinker to immobilize antibacterial furanone molecules on silicon oxide surfaces. This immobilization strategy is useful, especially for substrates and molecules that lack reactive functional groups. To this end, cleaned wafers were initially incubated in solutions of different concentrations of PFPA-silane to form a monolayer presenting azido groups on the surface. The functionalized surfaces were then treated with a furanone solution followed by illumination with UV light and extensive rinsing with ethanol to remove noncovalently adhered molecules, In the presented study, we demonstrate the ability to control the surface density of the immobilized furanone molecules by adjusting the concentration of PFPA-silane solution used for surface functionalization using complementary surface analytical techniques. The fluorine in PFPA-silane and the bromine in furanone molecules were convenient markers for the XPS study. The ellipsometric layer thickness of the immobilized furanone molecules on the surface decreased with decreasing PFPA-silane concentration, which correlated with a decline of water contact angle as a sign of film collapse. The intensity of characteristic azide vibration in the MTR IR spectra was monitored as a function of PFPA-silane concentration, and the peak disappeared completely after furanone application followed by UV irradiation. As a complementary technique to XPS, TOF-SIMS provided valuable information on the chemical and molecular structure of the modified surfaces and spatial distribution of the immobilized furanone molecules. Finally, this report presents a convenient, reproducible, and robust strategy to design antibacterial coating based on furanone compounds for applications in human health care.
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21.
  • Albet-Torres, Nuria, et al. (författare)
  • Long-Term Storage of Surface-Adsorbed Protein Machines
  • 2011
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 27:11, s. 7108-7112
  • Tidskriftsartikel (refereegranskat)abstract
    • The effective and simple long-term storage of complex functional proteins is critical in achieving commercially viable biosensors. This issue is particularly challenging in recently proposed types of nanobiosensors, where molecular-motor-driven transportation substitutes microfluidics and forms the basis for novel detection schemes. Importantly, therefore, we here describe that delicate heavy meromyosin (HMM)-based nanodevices (HMM motor fragments adsorbed to silanized surfaces and actin bound to HMM) fully maintain their function when stored at -20 degrees C for more than a month. The mechanisms for the excellent preservation of acto-HMM motor function upon repeated freeze thaw cycles are discussed. The results are important to the future commercial implementation of motor-based nanodevices and are of more general value to the long-term storage of any protein-based bionanodevice.
  •  
22.
  • Alexandrova, L, et al. (författare)
  • Confirmation of the heterocoagulation theory of flotation
  • 1999
  • Ingår i: Langmuir. - 0743-7463 .- 1520-5827. ; 15, s. 7464-7471
  • Tidskriftsartikel (refereegranskat)abstract
    • To model the flotation process, we have used the microscopic method developed by Scheludko to study the stability of an aqueous thin film containing tetradecyltrimethylammonium bromide ( C14TAB ) between an air bubble and a silica substrate. Experiments were performed at a range of C14TAB concentrations and pH values. Spontaneous rupture of the thin aqueous film was interpretated in terms of heterocoagulation resulting from the preferential adsorption of relatively low surfactant concentrations at the vapour/solution interface causing a net positive charge while the solution/silica interface remained negatively charged. In addition, during the the three-phase-contact (TPC) expansion or de-wetting step following film rupture, the movement of TPC across the silica substrate leads to transfer of amine from the vapour/solution interface to the vapour/silica. This process resembles a Langmuir-Blodgett deposition process and emphasized the importance of the solution/vapour interface in the de-wetting process.
  •  
23.
  • Ali Doosti, Baharan, 1991, et al. (författare)
  • Membrane Tubulation in Lipid Vesicles Triggered by the Local Application of Calcium Ions
  • 2017
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 33:41, s. 11010-11017
  • Tidskriftsartikel (refereegranskat)abstract
    • Experimental and theoretical studies on ion-lipid interactions predict that binding of calcium ions to cell membranes leads to macroscopic mechanical effects and membrane remodeling. Herein, we provide experimental evidence that a point source of Ca2+ acting upon a negatively charged membrane generates spontaneous curvature and triggers the formation of tubular protrusions that point away from the ion source. This behavior is rationalized by strong binding of the divalent cations to the surface of the charged bilayer, which effectively neutralizes the surface charge density of outer leaflet of the bilayer. The mismatch in the surface charge density of the two leaflets leads to nonzero spontaneous curvature. We probe this mismatch through the use of molecular dynamics simulations and validate that calcium ion binding to a lipid membrane is sufficient to generate inward spontaneous curvature, bending the membrane. Additionally, we demonstrate that the formed tubular protrusions can be translated along the vesicle surface in a controlled manner by repositioning the site of localized Ca2+ exposure. The findings demonstrate lipid membrane remodeling in response to local chemical gradients and offer potential insights into the cell membrane behavior under conditions of varying calcium ion concentrations.
  •  
24.
  • Alison, Lauriane, et al. (författare)
  • Emulsions Stabilized by Chitosan-Modified Silica Nanoparticles : pH Control of Structure-Property Relations
  • 2018
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 34:21, s. 6147-6160
  • Tidskriftsartikel (refereegranskat)abstract
    • In food-grade emulsions, particles with an appropriate surface modification can be used to replace surfactants and potentially enhance the stability of emulsions. During the life cycle of products based on such emulsions, they can be exposed to a broad range of pH conditions and hence it is crucial to understand how pH changes affect stability of emulsions stabilized by particles. Here, we report on a comprehensive study of the stability, microstructure, and macroscopic behavior of pH-controlled oil-in-water emulsions containing silica nanoparticles modified with chitosan, a food-grade polycation. We found that the modified colloidal particles used as stabilizers behave differently depending on the pH, resulting in unique emulsion structures at multiple length scales. Our findings are rationalized in terms of the different emulsion stabilization mechanisms involved, which are determined by the pH-dependent charges and interactions between the colloidal building blocks of the system. At pH 4, the silica particles are partially hydrophobized through chitosan modification, favoring their adsorption at the oil-water interface and the formation of Pickering emulsions. At pH 5.5, the particles become attractive and the emulsion is stabilized by a network of agglomerated particles formed between the droplets. Finally, chitosan aggregates form at pH 9 and these act as the emulsion stabilizers under alkaline conditions. These insights have important implications for the processing and use of particle-stabilized emulsions. On one hand, changes in pH can lead to undesired macroscopic phase separation or coalescence of oil droplets. On the other hand, the pH effect on emulsion behavior can be harnessed in industrial processing, either to tune their flow response by altering the pH between processing stages or to produce pH-responsive emulsions that enhance the functionality of the emulsified end products.
  •  
25.
  • Alison, Lauriane, et al. (författare)
  • Pickering and Network Stabilization of Biocompatible Emulsions Using Chitosan-Modified Silica Nanoparticles
  • 2016
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 32:50, s. 13446-13457
  • Tidskriftsartikel (refereegranskat)abstract
    • Edible solid particles constitute an attractive alternative to surfactants as stabilizers of food-grade emulsions for products requiring a long-term shelf life. Here, we report on a new approach to stabilize edible emulsions using silica nanoparticles modified by noncovalently bound chitosan oligomers. Electrostatic modification with chitosan increases the hydrophobicity of the silica nanoparticles and favors their adsorption at the oil water interface. The interfacial adsorption of the chitosan-modified silica particles enables the preparation of oil-in-water emulsions with small droplet sizes of a few micrometers through high-pressure homogenization. This approach enables the stabilization of food-grade emulsions for more than 3 months. The emulsion structure and stability can be effectively tuned by controlling the extent of chitosan adsorption on the silica particles. Bulk and interfacial rheology are used to highlight the two stabilization mechanisms involved. Low chitosan concentration (1 wt % with respect to silica) leads to the formation of a viscoelastic film of particles adsorbed at the oil water interface, enabling Pickering stabilization of the emulsion. By contrast, a network of agglomerated particles formed around the droplets is the predominant stabilization mechanism of the emulsions at higher chitosan content (5 wt % with respect to silica). These two pathways against droplet coalescence and coarsening open up different possibilities to engineer the long-term stabilization of emulsions for food applications.
  •  
26.
  • Almgren, Mats, et al. (författare)
  • Dispersed lipid liquid crystalline phases stabilized by a hydrophobically modified cellulose
  • 2007
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 23:5, s. 2768-2777
  • Tidskriftsartikel (refereegranskat)abstract
    • Aqueous dispersions of monoolein (MO) with a commercial hydrophobically modified ethyl hydroxyethyl cellulose ether (HMEHEC) have been investigated with respect to the morphologies of the liquid crystalline nanoparticles. Only very low proportions of HMEHEC are accepted in the cubic and lamellar phases of the monoolein−water system. Due to the broad variation of composition and size of the commercial polymer, no other single-phase regions were found in the quasi-ternary system. Interactions of MO with different fractions of the HMEHEC sample induced the formation of lamellar and reversed hexagonal phases, identified from SAXD, polarization microscopy, and cryogenic TEM examinations. In excess water (more than 90 wt %) coarse dispersions are formed more or less spontaneously, containing particles of cubic phase from a size visible by the naked eye to small particles observed by cryoTEM. At high polymer/MO ratios, vesicles were frequently observed, often oligo-lamellar with inter-lamellar connections. After homogenization of the coarse dispersions in a microfluidizer, the large particles disappeared, apparently replaced by smaller cubic particles, often with vesicular attachments on the surfaces, and by vesicles or vesicular particles with a disordered interior. At the largest polymer contents no proper cubic particles were found directly after homogenization but mainly single-walled defected vesicles with a peculiar edgy appearance. During storage for 2 weeks, the dispersed particles changed toward more well-shaped cubic particles, even in dispersions with the highest polymer contents. In some of the samples with low polymer/MO ratio, dispersed particles of the reversed hexagonal type were found. A few of the homogenized samples were freeze-dried and rehydrated. Particles of essentially the same types, but with a less well-developed cubic character, were found after this treatment.
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27.
  • Almgren, Mats, et al. (författare)
  • Nonideal Mixed Micelles of Fluorinated and Hydrogenous Surfactants in Aqueous Solution. NMR and SANS Studies of Anionic and Nonionic Systems
  • 2010
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 26:8, s. 5355-5363
  • Tidskriftsartikel (refereegranskat)abstract
    • Contrast variation SANS and F-19 chemical shifts were measured for three mixed equimolar micelle systems: sodium perfluorooctanoate (SPED) and sodiumdecylsulfate (SDeS) in 200 mM NaCl, lithium perlluorononanate LiPFN) and lithium dodecylsulfate (Li DS) in 200 mM LiCl, and a nonionic system C8F17C2H4(OC2H4)(9) and C12H25(OC2H4)(8) in water, all at 25 C. The chemical shift measurements allow the calculation of the average fraction of nearest neighbors of each kind around the reporter group (the trifluoromethyl group). A preference for like neighbors were found in all systems, smallest in the SDeS/SPFO system and largest in the nonionic system, but in all cases substantially smaller than expected at critical conditions. From the SANS measurements the width of the micelle composition distribution was obtained. For the ionic systems similar values were obtained, showing a broadening compared to ideal mixtures, but not broad enough for demixing or clearly bimodal distributions. In the nonionic system the width was estimated as sigma = 0.18 and 0.22 using two different evaluation methods. These values suggest that the system is close to critical conditions. The lower value refers to a direct modeling of the system, assuming an ellipsoidal shape and a Gaussian composition distribution. The modeling showed the nonionic mixed micelles to be prolate ellipsoids with axial ratio 2.2 and an aggregation number larger than 100. whereas the two ionic systems fitted best to oblate shapes (axial ratios 0.8 and 0.65 for SDeS/SPFO and LiDS/LiPFN. respectively) and aggregation numbers of 60 for both.
  •  
28.
  • An, Junxue, et al. (författare)
  • Influence of Glycosylation on Interfacial Properties of Recombinant Mucins : Adsorption, Surface Forces, and Friction
  • 2017
  • Ingår i: Langmuir. - : American Chemical Society. - 0743-7463 .- 1520-5827. ; 33:18, s. 4386-4395
  • Tidskriftsartikel (refereegranskat)abstract
    • Interfacial properties of two brush-with-anchor mucins, C-P55 and C-PSLex, have been investigated at the aqueous solution/poly(methyl methacrylate) (PMMA) interface. Both are recombinant mucin-type fusion proteins, produced by fusing the glycosylated mucin part of P-selectin glycoprotein ligand-1 (PSLG-1) to the Fc part of a mouse immunoglobulin in two different cells. They are mainly expressed as dimers upon production. Analysis of the O-glycans shows that the C-PSLex mucin has the longer and more branched side chains, but C-P55 has slightly higher sialic acid content. The adsorption of the mucins to PMMA surfaces was studied by quartz crystal microbalance with dissipation. The sensed mass, including the adsorbed mucin and water trapped in the layer, was found to be similar for these two mucin layers. Atomic force microscopy with colloidal probe was employed to study surface and friction forces between mucin-coated PMMA surfaces. Purely repulsive forces of steric origin were observed between mucin layers on compression, whereas a small adhesion was detected between both mucin layers on decompression. This was attributed to chain entanglement. The friction force between C-PSLex-coated PMMA is lower than that between C-P55-coated PMMA at low loads, but vice versa at high loads. We discuss our results in terms of the differences in the glycosylation composition of these two mucins.
  •  
29.
  • An, Junxue, et al. (författare)
  • Temperature-Dependent Adsorption and Adsorption Hysteresis of a Thermoresponsive Diblock Copolymer
  • 2014
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 30:15, s. 4333-4341
  • Tidskriftsartikel (refereegranskat)abstract
    • A nonionic-cationic diblock copolymer, poly(2-isopropyl-2-oxazoline)(60)-b-poly((3-acrylamidopropyl)- trimethylammonium chloride)(17), (PIPOZ(60)-b-PAMPTMA(17)), was utilized to electrostatically tether temperature-responsive PIPOZ chains to silica surfaces by physisorption. The effects of polymer concentration, pH, and temperature on adsorption were investigated using quartz crystal microbalance with dissipation monitoring and ellipsometry. The combination of these two techniques allows thorough characterization of the adsorbed layer in terms of surface excess, thickness, and water content. The high affinity of the cationic PAMPTMA(17) block to the negatively charged silica surface gives rise to a high affinity adsorption isotherm, leading to (nearly) irreversible adsorption with respect to dilution. An increase in solution pH lowers the affinity of PIPOZ to silica but enhances the adsorption of the cationic block due to increasing silica surface charge density, which leads to higher adsorption of the cationic diblock copolymer. Higher surface excess is also achieved at higher temperatures due to the worsening of the solvent quality of water for the PIPOZ block. Interestingly, a large hysteresis in adsorbed mass and other layer properties was observed when the temperature was cycled from 25 to 45 degrees C and then back to 25 degrees C. Possible causes for this temperature hysteresis are discussed.
  •  
30.
  • An, Junxue, et al. (författare)
  • Tethered Poly(2-isopropyl-2-oxazoline) Chains : Temperature Effects on Layer Structure and Interactions Probed by AFM Experiments and Modeling
  • 2015
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 31:10, s. 3039-3048
  • Tidskriftsartikel (refereegranskat)abstract
    • Thermoresponsive polymer layers on silica surfaces have been obtained by utilizing electrostatically driven adsorption of a cationic-nonionic diblock copolymer. The cationic block provides strong anchoring to the surface for the nonionic block of poly(2-isopropyl-2-oxazoline), referred to as PIPOZ. The PIPOZ chain interacts favorably with water at low temperatures, but above 46 degrees C aqueous solutions of PIPOZ phase separate as water becomes a poor solvent for the polymer. We explore how a change in solvent condition affects interactions between such adsorbed layers and report temperature effects on both normal forces and friction forces. To gain further insight, we utilize self-consistent lattice mean-field theory to follow how changes in temperature affect the polymer segment density distributions and to calculate surface force curves. We find that with worsening of the solvent condition an attraction develops between the adsorbed PIPOZ layers, and this observation is in good agreement with predictions of the mean-field theory. The modeling also demonstrates that the segment density profile and the degree of chain interpenetration under a given load between two PIPOZ-coated surfaces rise significantly with increasing temperature.
  •  
31.
  • Andersson, John, 1993, et al. (författare)
  • Control of Polymer Brush Morphology, Rheology, and Protein Repulsion by Hydrogen Bond Complexation
  • 2021
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 37:16, s. 4943-4952
  • Tidskriftsartikel (refereegranskat)abstract
    • Polymer brushes are widely used to alter the properties of interfaces. In particular, poly(ethylene glycol) (PEG) and similar polymers can make surfaces inert toward biomolecular adsorption. Neutral hydrophilic brushes are normally considered to have static properties at a given temperature. As an example, PEG is not responsive to pH or ionic strength. Here we show that, by simply introducing a polymeric acid such as poly(methacrylic acid) (PMAA), the highly hydrated brush barrier can change its properties entirely. This is caused by multivalent hydrogen bonds in an extremely pH-sensitive process. Remarkably, it is sufficient to reduce the pH to 5 for complexation to occur at the interface, which is two units higher than in the corresponding bulk systems. Below this critical pH, PMAA starts to bind to PEG in large amounts (comparable to the PEG amount), causing the brush to gradually compact and dehydrate. The brush also undergoes major rheology changes, from viscoelastic to rigid. Furthermore, the protein repelling ability of PEG is lost after reaching a threshold in the amount of PMAA bound. The changes in brush properties are tunable and become more pronounced when more PMAA is bound. The initial brush state is fully recovered when releasing PMAA by returning to physiological pH. Our findings are relevant for many applications involving functional interfaces, such as capture-release of biomolecules.
  •  
32.
  • Andersson, Martin, 1974, et al. (författare)
  • Detection of single ion channel activity on a chip using tethered bilayer membranes
  • 2007
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 23:6, s. 2924-2927
  • Tidskriftsartikel (refereegranskat)abstract
    • Membrane-bound ion channels are promising biological receptors since they allow for the stochastic detection of analytes at high sensitivity. For stochastic sensing, it is necessary to measure the ion currents associated with single ion channel opening and closing events. However, this calls for stability, high reproducibility, and long lifetimes. A critical issue to overcome is the low stability of the ion channel environment, that is, the bilayer membrane. A promising technique to surmount this is to connect the lower part of the membrane to a surface forming a tethered bilayer membrane. By reconstituting the synthetic ion channel, gramicidin A, into a tethered bilayer as part of a microchip design, we have been able to record the activity of single ion channels. The observed activity was compared with that obtained by a conventional electrophysiology method, tip dipping, to confirm its authenticity. These findings allow for the construction of stable biosensors based on ion channels and provide a novel technique for the characterization of ion channel activity.
  •  
33.
  • Andersson, Martin, et al. (författare)
  • Single microgel particle studies demonstrate the influence of hydrophobic interactions between charged micelles and oppositely charged polyions.
  • 2005
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 21:9, s. 3773-3781
  • Tidskriftsartikel (refereegranskat)abstract
    • The binding of two cationic surfactants, dodecyltrimethylammonium bromide (DoTAB) and N-(1,1,2,2-tetrahydroperfluorodecanyl)pyridinium bromide (HFDePB), to covalently cross-linked sodium poly(styrenesulfonate) (PSS) microgels has been investigated by means of micromanipulator-assisted time-resolved light microscopy on single gels. It is demonstrated that repeated measurements on the same microgel under conditions of controlled liquid flow give highly reproducible results. The two surfactants are found to behave very differently with respect to degree of swelling, surfactant distribution in the gels, both during shrinking and at equilibrium, and kinetics of volume changes induced by them. The main difference is attributed to the presence of a hydrophobic interaction between PSS and the DoTAB micelles, absent in the case of HFDePB. Kinetic shrinking curves are recorded and analyzed using a model for steady-state transport of surfactant between the solution and the gels. Aggregation numbers for DoTAB in PSS solutions obtained from fluorescence quenching measurements are presented. A strong dependence on the surfactant-to-polyion concentration ratio is observed. Relations between surfactant binding isotherms, phase diagrams for linear polyelectrolyte/surfactant/water systems, and the binding to gels are discussed.
  •  
34.
  • Andersson, Martin, et al. (författare)
  • The vibrational spectra of methyl groups in methylthiolate and methoxy adsorbed on Cu(100)
  • 2002
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 18:10, s. 3759-3762
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • We show that the difference in the infrared vibrational spectrum of C-H stretch modes arising from the methyl group of two surface intermediates, methylthiolate and methoxy, originates from the difference in the methyl deformation modes frequencies of the two intermediates. Importantly, while the vibrational fingerprint of the two methyl groups are not transferable between the intermediates, the Fermi resonance coupling constants of the methyl group are.
  •  
35.
  • Andersson, Nina, et al. (författare)
  • Combined Emulsion and Solvent Evaporation (ESE) Synthesis Route to Well-Ordered Mesoporous Materials
  • 2007
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 23:3, s. 1459-1464
  • Tidskriftsartikel (refereegranskat)abstract
    • Control over morphol. and internal mesostructure of surfactant templated silicas remains a challenge, esp. when considering scaling lab. syntheses up to industrial vols. Here we report a method combining emulsification with the evapn.-induced self-assembly (EISA) method for prepg. spherical, mesoporous silica particles. This emulsion and solvent evapn. (ESE) method has several potential advantages over classic pptn. routes: it is easily scaled while providing superior control over stoichiometric homogeneity of templating surfactants and inorg. precursors, and particle sizes and distributions are detd. by principles developed for manipulating droplet sizes within water-in-oil emulsions. To demonstrate the method, triblock copolymer P104 is used as a templating amphiphile, generating unusually well-ordered 2D hexagonal (P6mm) mesoporous silica, while particle sizes and morphologies were controlled by varying the type of emulsifier and the method for emulsification. [on SciFinder(R)]
  •  
36.
  • Andersson, N, et al. (författare)
  • Combined emulsion and solvent evaporation (ESE) synthesis route to well-ordered mesoporous materials
  • 2007
  • Ingår i: Langmuir. - 0743-7463 .- 1520-5827. ; 23:3, s. 1459-1464
  • Tidskriftsartikel (refereegranskat)abstract
    • Control over morphology and internal mesostructure of surfactant templated silicas remains a challenge, especially when considering scaling laboratory syntheses up to industrial volumes. Herewereport a method combining emulsification with the evaporation-induced self-assembly (EISA) method for preparing spherical, mesoporous silica particles. This emulsion and solvent evaporation (ESE) method has several potential advantages over classic precipitation routes: it is easily scaled while providing superior control over stoichiometric homogeneity of templating surfactants and inorganic precursors, and particle sizes and distributions are determined by principles developed for manipulating droplet sizes within water-in-oil emulsions. To demonstrate the method, triblock copolymer P104 is used as a templating amphiphile, generating unusually well-ordered 2D hexagonal (P6mm) mesoporous silica, while particle sizes and morphologies were controlled by varying the type of emulsifier and the method for emulsification
  •  
37.
  • Andersson Trojer, Markus, 1981, et al. (författare)
  • The Importance of Proper Anchoring of an Amphiphilic Dispersant for Colloidal Stability
  • 2012
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 28:19, s. 4047-4050
  • Tidskriftsartikel (refereegranskat)abstract
    • Highly stable poly(methyl methacrylate) (PMMA) based microcapsule suspensions without excess dispersant are obtained via the solvent evaporation route using poly(methyl methacrylate)-block-poly(sodium methacrylate) or poly(methyl methacrylate)-block-poly(sodium acrylate) diblock copolymers as dispersant. The stable suspension is characterized by a high ζ-potential that does not change with time or after washing steps. It is indirectly proven on model PMMA surfaces using quartz crystal microbalance with dissipation monitoring that the PMMA block of the copolymer is embedded in the underlying PMMA microcapsule. Such anchoring of the dispersant is key for the good colloidal stability.
  •  
38.
  • Angelescu, Daniel, et al. (författare)
  • Adsorption of Branched-Linear Polyethyleneimine-Ethylene Oxide Conjugate on Hydrophilic Silica Investigated by Ellipsometry and Monte Carlo Simulations
  • 2011
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 27:16, s. 9961-9971
  • Tidskriftsartikel (refereegranskat)abstract
    • The adsorption of and conformation adopted by a branched-linear polymer conjugate to the hydrophilic silica aqueous solution interface have been studied by in situ null ellipsornetry and Monte Carlo simulations. The conjugate is a highly branched polyethyleneimine structure with ethyleneoxide chains grafted to its primary and secondary amino groups. In situ null ellipsometry demonstrated that the polymer conjugate adsorbs to the silica surface from water and aqueous solution of 1 mM asymmetric divalent salt (calcium and magnesium chloride to emulate hard water) over a large pH range. The adsorbed amount is hardly affected by pH and large charge reversal on the negatively charged silica surface occurred at pH = 4.0, due to the adsorption of the cationic polyelectrolyte. The Monte Carlo simulations using an appropriate coarse-grained model of the polymer in solution predicted a core shell structure with no sharp boundary between the ethyleneimine and ethyleneoxide moieties. The structure at the interface is similar to that in solution when the polymer degree of protonation is low or moderate while at high degree of protonation the strong electrostatic attraction between the ethyleneimine core and oppositely charged silica surface distorts the ethyleneoxide shell so that an "anemone"-like configuration is adopted. The adsorption of alkyl benzene sulfonic acid (LAS) to a preadsorbed polymer layer was also investigated by null ellipsometry. The adsorption data brought additional support for the existence of a strong polymer adsorption and showed the presence of a binding which was further enhanced by the decreased solvency of the surfactant in the salt solution and confirmed the surface charge reversal by the polymer adsorption at pH = 4.0.
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39.
  • Angelescu, Daniel, et al. (författare)
  • Monte Carlo simulation of the mean force between two like-charged macroions with simple 1 : 3 salt added
  • 2003
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 19:23, s. 9661-9668
  • Tidskriftsartikel (refereegranskat)abstract
    • The mean force and the potential of the mean force between two like- harged macroions with monovalent counterions and added simple 1:3 salt described within the primitive model and confined in a cylindrical cell have been investigated by Monte Carlo simulations. Without additional salt, a strongly repulsive mean force was obtained at all macroion separations, consistent with a stable solution of macroions. At a trivalent counterion-to-macroion charge ratio of 0.4, the mean force became attractive at short separations but still possessed a substantial repulsion at longer separations. However, at a stoichiometric amount of trivalent counterions, no long-range repulsion remained and the attraction became substantial (approximate to5kT attraction at a short separation). In excess of salt, the magnitude of the attractive mean force was reduced. The attractive component of the mean force originates from spatial correlations between counterions residing near different macroions and is not captured by mean-field theories such as the Poisson-Boltzmann equation or any of its simplific tions. The observed sequence of mean forces is consistent with recent experimental observations on an aqueous solution of sodium dodecyl sulfate micelles as Al(NO3)(3) was added.
  •  
40.
  • Angelescu, Daniel, et al. (författare)
  • Viscoelastic properties of sodium dodecyl sulfate with aluminum salt in aqueous solution
  • 2003
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 19:22, s. 9155-9161
  • Tidskriftsartikel (refereegranskat)abstract
    • The rheological properties of wormlike micellar solutions formed by the pseudo-ternary system sodium dodecyl sulfate (SDS)-Al(NO3)(3)-H2O have been studied at a fixed molar ratio Al(NO3)(3):SDS = 5.92:1 as a function of surfactant concentration. The linear data show that solutions behave as a Maxwell fluid and there are two well-defined domains characterized by scaling laws for surfactant concentration, with a maximum in the viscosity-surfactant concentration curve. Prior to the maximum, the system consists of linear micelles, and eta(0) (zero-shear rate viscosity) and tau(R) (relaxation time) are found to scale with surfactant concentration with exponents higher than those predicted by the theory of Cates. The results in the second domain are not reflected by the dynamic behavior of entangled wormlike micelles, and they are interpreted in terms of formation of connected micelles. The nonlinear rheology is governed by the shear banding effect occurring for viscous entangled wormlike micellar solutions and branched micelles, and the properties identified by reduced stress sigma(p)/G(0) and the Weissenberg number, y(c)tauR, are compared to the values predicted on the basis of the theoretical model.
  •  
41.
  • Angelico, R, et al. (författare)
  • Biocompatible lecithin organogels: Structure and phase equilibria
  • 2005
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 21:1, s. 140-148
  • Tidskriftsartikel (refereegranskat)abstract
    • The microstructure of organogels formed upon the addition of tiny amounts of water to a solution of lecithin in fatty acid esters (viz. isopropylpalmitate and ethyloleate) was investigated by means of molecular self-diffusion measurements. In both systems lecithin and water form disconnected cylindrical reverse micelles. The ternary phase map for the lecithin/water/isopropylpalmitate has been investigated in detail. The organogel exists in a narrow region close to the lecithin-oil binary axis; for higher water content equilibrium between lamellae and reverse micelles is found. Lamellar phase occupies the lecithin-rich region, close to the lecithin corner (with the exception of a small island of hexagonal phase) and coexists with neat water close to the water-lecithin axis. The remaining part of the phase map shows the three-phase coexistence of water, oil, and lamellar phase.
  •  
42.
  • Angelico, R, et al. (författare)
  • Phase behavior of the lecithin/water/isooctane and lecithin/water/decane systems
  • 2004
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 20:3, s. 619-631
  • Tidskriftsartikel (refereegranskat)abstract
    • The isothermal pseudo-ternary-phase diagram was determined at 25 degreesC for systems composed of lecithin, water, and, as oil, either isooctane or decane. This was accomplished by a combination of polarizing microscopy, small-angle X-ray scattering, and NMR techniques. The lecithin-rich region of the phase diagram is dominated by a lamellar liquid-crystalline phase (L-alpha). For lecithin contents less than 60% and low hydration (mole ratio water/lecithin = W-0 < 5.5), the system forms a viscous gel of branched cylindrical reverse micelles. With increase in the water content, the system phase separates into two phases, which is either gel in equilibrium with essentially pure isooctane (for lecithin < 25%) or a gel in equilibrium with L-alpha, (for lecithin > 25%). These two-phase regions are very thin with respect to water dilution. For 8 < W-0 < 54 very stable water-in-oil emulsions form. It is only after ripening for more than I year that the large region occupied by the emulsion reveals a complex pattern of stable phases. Moving along water dilution lines, one finds (i) the coexistence of gel, isooctane and L-alpha,(ii) equilibrium between reverse micelles and spherulites, and, finally, (iii) disconnected reverse micelles that fail to solubilize water for W-0 > 54. This results in a Winsor II phase equilibrium at low lecithin content, while for lecithin > 20% the neat water is in equilibrium with a reverse hexagonal phase and an isotropic liquid-crystalline phase. The use of the decane as oil does not change the main features of the phase behavior.
  •  
43.
  • Antunes, Filipe, et al. (författare)
  • Mixed systems of hydrophobically modified polyelectrolytes: Controlling rheology by charge and hydrophobe stoichiometry and interaction strength
  • 2005
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 21:22, s. 10188-10196
  • Tidskriftsartikel (refereegranskat)abstract
    • Rheology and phase separation were investigated for aqueous mixtures of two oppositely charged hydrophobically modified polyelectrolytes. The typical phase separation, normally seen for oppositely charged polymer mixtures, is dramatically reduced by the presence of hydrophobic modification, and phase separation is only detected close to the point of charge neutralization. While the two polyelectrolytes separately can give high viscosities and a gel-like behavior, a pronounced maximum in viscosity and storage modulus with the mixing ratio of the polyelectrolytes is observed; the maximum is located between the points of charge and hydrophobe stoichiometry and reflects a combination of hydrophobic and electrostatic association. Lowering the charge density of the anionic polymer leads to a strengthened association at first, but at lower charge densities there is a weakened association due to the onset of phase separation. The strength of the electrostatic interaction was modified by adding salt. Increased ionic strength can lead to phase separation and to increased or decreased viscosity depending on the polyelectrolyte mixing ratio.
  •  
44.
  • Antunes, Filipe, et al. (författare)
  • Network formation of catanionic vesicles and oppositely charged polyelectrolytes. Effect of polymer charge density and hydrophobic modification
  • 2004
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 20:11, s. 4647-4656
  • Tidskriftsartikel (refereegranskat)abstract
    • In nonequimolar solutions of a cationic and an anionic surfactant, vesicles bearing a net charge can be spontaneously formed and apparently exist as thermodynamically stable aggregates. These vesicles can associate strongly with polymers in solution by means of hydrophobic and/or electrostatic interactions. In the current work, we have investigated the rheological and microstructural properties of mixtures of cationic polyelectrolytes and net anionic sodium dodecyl sulfate/didodecyldimethylammonium bromide vesicles. The polyelectrolytes consist of two cationic cellulose derivatives with different charge densities; the lowest charge density polymer contains also hydrophobic grafts, with the number of charges equal to the number of grafts. For both systems, polymer-vesicle association leads to a major increase in viscosity and to gel-like behavior, but the viscosity effects are more pronounced for the less charged, hydrophobically modified polymer. Evaluation of the frequency dependence of the storage and loss moduli for the two systems shows further differences in behavior: while the more long-lived cross-links occur for the more highly charged hydrophilic polymer, the number of cross-links is higher for the hydrophobically modified polymer. Microstructure studies by cryogenic transmission electron microscopy indicate that the two polymers affect the vesicle stability in different ways. With the hydrophobically modified polymer, the aggregates remain largely in the form of globular vesicles and faceted vesicles (polygon-shaped vesicles with largely planar regions). For the hydrophilic polycation, on the other hand, the surfactant aggregate structure is more extensively modified: first, the vesicles change from a globular to a faceted shape; second, there is opening of the bilayers leading to holey vesicles and ultimately to considerable vesicle disruption leading to planar bilayer, disklike aggregates. The faceted shape is tentatively attributed to a crystallization of the surfactant film in the vesicles. It is inferred that a hydrophobically modified polyion with relatively low charge density can better stabilize vesicles due to formation of molecularly mixed aggregates, while a hydrophilic polyion with relatively high charge density associates so strongly to the surfactant films, due to strong electrostatic interactions, that the vesicles are more perturbed and even disrupted.
  •  
45.
  • Arleth, Lise, et al. (författare)
  • Block-copolymer micro-emulsion with solvent-induced segregation
  • 2007
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 23:4, s. 2117-2125
  • Tidskriftsartikel (refereegranskat)abstract
    • Reverse micelle formation of the poly(ethylene oxide)/poly(propylene oxide) block-copolymer (EO)(13)(PO)(30)(EO)(13) (L64) in p-xylene was investigated as a function of water content and copolymer content, using small-angle neutron scattering (SANS). PEO/PPO block-copolymers are generally soluble in xylene but without forming aggregates. However, the effective block segregation increases dramatically upon addition of small amounts of water, and micelles form. The SANS data were analyzed using an absolute scale model fitting approach. This way, a detailed quantitative description of the system in terms of unimer concentration, micelle structure, and aggregation number as well as particle-particle interactions can be obtained. This approach throws light on very atypical features of the system as compared to standard amphiphilic systems. Data from samples measured along water-swelling lines with fixed EO/p-xylene-d(10) molar ratios show that reverse micelles are formed at the water/EO molar ratio, W-0 congruent to 0.2, independent of copolymer concentration. The majority of the block-copolymers are on a free monomer state (unimer state) at this W-0. Increasing W-0 above 0.2 only has a small effect on the micelle size. However, it does induce a strong increase of the total number of micelles and induce a corresponding decrease of the unimer concentration. On the other hand, increasing the overall copolymer concentration at fixed W-0 gives rise to a significant decrease of the micelle size in terms of the micellar aggregation number. This observed behavior is totally different from what is normally observed for binary surfactant-solvent systems and droplet micro-emulsion systems, respectively. We believe that the atypical behavior is a result of the unusually weak segregation in the system, and we are not aware of previous discussions of the phenomenon for reverse micellar systems.
  •  
46.
  • Arleth, L., et al. (författare)
  • Small-angle neutron scattering study of the growth behavior, flexibility, and intermicellar interactions of wormlike SDS micelles in NaBr aqueous solutions
  • 2002
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 18:14, s. 5343-5353
  • Tidskriftsartikel (refereegranskat)abstract
    • SDS wormlike micelles in water with NaBr are studied using small-angle neutron scattering. SDS concentrations ranging from 0.08 to 8.6 % vol in NaBr aqueous solutions at salinities from 0.6 to 1.0 M are covered. The scattering data are analyzed using a novel approach based on polymer theory and the results of Monte Carlo simulations. The method makes it possible to give a full interpretation of the scattering data, even for the entangled micellar solutions occurring at high concentrations and high salinities. Analysis of the scattering data at zero scattering angle demonstrates that the length of the micelles increases according to a power law as a function of concentration in the studied interval. The analysis furthermore shows that the length of the micelles increases exponentially with increasing salinity. The scattering data in the full range of scattering angles are analyzed using a model for polydisperse wormlike micelles where excluded volume effects are taken into account via an expression based on the polymer reference interaction site model (PRISM). This part of the analysis show that the micelles become more flexible as the salinity increases, which is due to an increased screening of the ionic micelles.
  •  
47.
  • Arnold, T, et al. (författare)
  • Surfactant Behavior of Sodium Dodecylsulfate in Deep Eutectic Solvent Choline Chloride/Urea.
  • 2015
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 31:47, s. 12894-12902
  • Tidskriftsartikel (refereegranskat)abstract
    • Deep eutectic solvents (DES) resemble ionic liquids but are formed from an ionic mixture instead of being a single ionic compound. Here we present some results that demonstrate that surfactant sodium dodecyl sulfate (SDS) remains surface-active and shows self-assembly phenomena in the most commonly studied DES, choline chloride/urea. X-ray reflectivity (XRR) and small angle neutron scattering (SANS) suggest that the behavior is significantly different from that in water. Our SANS data supports our determination of the critical micelle concentration using surface-tension measurements and suggests that the micelles formed in DES do not have the same shape and size as those seen in water. Reflectivity measurements have also demonstrated that the surfactants remain surface-active below this concentration.
  •  
48.
  • Arumughan, Vishnu, 1994, et al. (författare)
  • Anion-Specific Adsorption of Carboxymethyl Cellulose on Cellulose
  • 2023
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 39:42, s. 15014-15021
  • Tidskriftsartikel (refereegranskat)abstract
    • Integration of fiber modification step with a modern pulp mill is a resource efficient way to produce functional fibers. Motivated by the need to integrate polymer adsorption with the current pulping system, anion-specific effects in carboxymethylcellulose (CMC) adsorption have been studied. The QCM-D adsorption experiments revealed that CMC adsorption to the cellulose model surface is prone to anion-specific effects. A correlation was observed between the adsorbed CMC and the degree of hydration of the co-ions present in the magnesium salts. The presence of a chaotropic co-ion such as nitrate increased the adsorption of CMC on cellulose compared to the presence of the kosmotropic sulfate co-ion. However, anion-specificity was not significant in the case of salts containing zinc cations. The hydration of anions determines the distribution of the ions at the interface. Chaotropic ions, such as nitrates, are likely to be distributed near the chaotropic cellulose surface, causing changes in the ordering of water molecules and resulting in greater entropy gain once released from the surface, thus increasing CMC adsorption.
  •  
49.
  • Asencio, Rubén Alvarez, et al. (författare)
  • Ionic Liquid Nanotribology : Stiction Suppression and Surface Induced Shear Thinning
  • 2012
  • Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 28:26, s. 9967-9976
  • Tidskriftsartikel (refereegranskat)abstract
    • The friction and adhesion between pairs of materials (silica, alumina, and polytetrafluoroethylene) have been studied and interpreted in terms of the long-ranged interactions present. In ambient laboratory air, the interactions are dominated by van der Waals attraction and strong adhesion leading to significant frictional forces. In the presence of the ionic liquid (IL) ethylammonium nitrate (EAN) the van der Waals interaction is suppressed and the attractive/adhesive interactions which lead to "stiction" are removed, resulting in an at least a 10-fold reduction in the friction force at large applied loads. The friction coefficient for each system was determined; coefficients obtained in air were significantly larger than those obtained in the presence of EAN (which ranged between 0.1 and 0.25), and variation in the friction coefficients between systems was correlated with changes in surface roughness. As the viscosity of ILs can be relatively high, which has implications for the lubricating properties, the hydrodynamic forces between the surfaces have therefore also been studied. The linear increase in repulsive force with speed, expected from hydrodynamic interactions, is clearly observed, and these forces further inhibit the potential for stiction. Remarkably, the viscosity extracted from the data is dramatically reduced compared to the bulk value, indicative of a surface ordering effect which significantly reduces viscous losses.
  •  
50.
  • Assarsson, Anna, et al. (författare)
  • Effects of polyamino acids and polyelectrolytes on amyloid β fibril formation
  • 2014
  • Ingår i: Langmuir. - : The American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 30:29, s. 8812-8
  • Tidskriftsartikel (refereegranskat)abstract
    • The fibril formation of the neurodegenerative peptide amyloid β (Aβ42) is sensitive to solution conditions, and several proteins and peptides have been found to retard the process. Aβ42 fibril formation was followed with ThT fluorescence in the presence of polyamino acids (poly-glutamic acid, poly-lysine, and poly-threonine) and other polymers (poly(acrylic acid), poly(ethylenimine), and poly(diallyldimethylammonium chloride). An accelerating effect on the Aβ42 aggregation process is observed from all positively charged polymers, while no effect is seen from the negative or neutral polymers. The accelerating effect is dependent on the concentration of positive polymer in a highly reproducible manner. Acceleration is observed from a 1:500 polymer to Aβ42 weight ratio and up. Polyamino acids and the other polymers exert quantitatively the same effect at the same concentrations based on weight. Fibrils are formed in all cases as verified by transmission electron microscopy. The concentrations of polymers required for acceleration are too low to affect the Aβ42 aggregation process through increased ionic strength or molecular crowding effects. Instead, the acceleration seems to arise from the locally increased Aβ42 concentration near the polymers, which favors association and affects the electrostatic environment of the peptide.
  •  
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