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- Hien Tran, Thi, et al.
(författare)
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Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway
- 2016
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Ingår i: Biomedical and Pharmacology Journal. - : Oriental Scientific Publishing Company. - 0974-6242. ; 9:2, s. 519-524
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Tidskriftsartikel (refereegranskat)abstract
- p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.
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| 2. |
- Kumari, G., et al.
(författare)
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Impact of Counseling based Edu Vaccine on the Control and Prevention of COVID-19 pandemic
- 2023
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Ingår i: Biomedical and Pharmacology Journal. - : Oriental Scientific Publishing Company. - 0974-6242. ; 16:4, s. 2069-2081
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Tidskriftsartikel (refereegranskat)abstract
- Millions of people throughout the world are affected by the coronavirus outbreak brought on by the pandemic Coronavirus Disease (COVID-19), which is the first significant human catastrophe in history. This study aimed to assess the effect of counseling based Edu Vaccine on prevention and control of COVID-19 pandemic. This pre and post designed, prospective, study was conducted in different states of India using an online survey. A 30-items questionnaire as an instrument was sent to 1597 potential responders. The responded participants were enrolled as study participants and divided into counseling and non-counseling groups. The obtained data were analyzed using SPSS version 21. Chi-square test was used to assess the level of association among variables and independent t-test was used to compare participants' demographic and socioeconomic measurements. Out of 1597 only 829 participants responded and completed the survey questionnaire. At baseline, half of the population found that the symptoms of COVID include fever, cough and trouble breathing, but after the counseling a significant change was observed (p<0.001) in the counseling group. 91.7% population were agreed that social distancing, maintain hygiene and public awareness can help to control the community spread or 3rd stage of COVID-19. Around 96 % of the population in the counseling group was aware of the preventive measures recommended by WHO to avoid COVID-19 infection after the counseling. A significant improvement was observed in general population's the knowledge levels regarding COVID-19 and its preventive measures. We observed that people were aware of COVID-19 and preventive masseurs but they do not adhere so there is an urgent need to continuous educational campaigns with follow-ups that target less-educated, lower-income population and further studies are warranted.
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