| 1. |
- André-Petersson, Lena, et al.
(författare)
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Cognitive abnormalities and cerebral perfusion defects in a community-dwelling cohort of elderly men with MMSE within the normal range
- 2018
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Ingår i: Aging, Neuropsychology, and Cognition. - : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 25:2, s. 200-212
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Mini Mental State Examination’s (MMSE’s) sensitivity in its upper level is questioned, hence we investigated cognitive abnormalities and defects in regional cerebral blood flow (rCBF) in elderly with MMSE scores ≥24. Methods: One hundred and four men at age 81 with MMSE scores ≥24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with neuropsychological test battery, and their rCBF was estimated using 99mTc-HMPAO SPECT. Results: MMSE was very sparsely correlated with rCBF. Instead, visuo-spatial tests were correlated with rCBF in parietal and occipital lobe, verbal tests with rCBF in frontal and temporal-parietal lobes, and most of all between Digit Symbol and all rCBF regions, especially in subcortical gray and white matter. In a cluster of low achievers, test of Synonyms, followed by Digit Symbol and Benton test, had highest discriminatory importance. Low achievers had generalized rCBF changes especially in subcortical areas. Only lower scores on two MMSE items, figure drawing and calculation, could discriminate the clusters. Conclusion: A substantial number of octogenarian men with MMSE ≥ 24p have widespread rCBF changes corresponding to a decreased speeded performance and verbal capacity.
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| 2. |
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| 3. |
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| 4. |
- Classon, Elisabet, et al.
(författare)
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A quick test of cognitive speed (AQT) : regression-based norms for cognitively healthy 80 to 94-year olds
- 2022
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Ingår i: Aging, Neuropsychology and Cognition. - : ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD. - 1382-5585 .- 1744-4128. ; 29:5, s. 820-839
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Tidskriftsartikel (refereegranskat)abstract
- Slowed processing speed is part of normal aging but also a symptom of many diseases, including dementia. A Quick Test of Cognitive Speed (AQT) consists of three conditions: color naming (AQT1), form naming (AQT2) and dual color-form naming (AQT3) and offers a user-friendly assessment of processing speed that is used internationally to identify cognitive impairment in elderly patients. Appropriate age-norms have however been lacking. This study provides regression-based norms derived from a Swedish sample of 158 cognitively healthy 80 to 94-year olds. The results show age effects in all three conditions, a non-linear education effect in AQT1, and age by gender interactions in AQT2 and AQT3: men performed worse with increasing age, but women remained on a par. However, irrespective of age and gender, AQT2 and AQT3 mean raw and predicted scores were slower than the hitherto recommended cutoff criteria for suspected cognitive impairment.
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| 5. |
- de Frias, Cindy, et al.
(författare)
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Sex differences in cognition are stable over a 10-year period in adulthood and old age.
- 2006
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Ingår i: Aging, Neuropsychology and Cognition. - : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 13:3-4, s. 574-587
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Tidskriftsartikel (refereegranskat)abstract
- Sex differences in declarative memory and visuospacial ability are robust in cross-sectional studies. The present longitudinal study examined whether sex differences in cognition were present over a 10-year period, and whether age modified the magnitude of sex differences. Tests assessing episodic and semantic memory, and visuospatial ability were administered to 625 nondemented adults (initially aged 35-80 years), participating in the population based Betula study at two follow-up occasions. There was stability of sex differences across five age groups and over a 10-year period. Women performed at a higher level than men on episodic recall, face and verbal recognition, and semantic fluency, whereas men performed better than women on a task assessing visuospatial ability. Sex differences in cognitive functions are stable over a 10-year period and from 35 to 90 years of age. Decreasing levels of estrogen in women and sex differences in age-related cortical atrophy do not seem to influence cognitive sex differences.
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| 6. |
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| 7. |
- Derwinger, Anna, et al.
(författare)
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Remembering Numbers in Old Age : Mnemonic Training Versus Self-Generated Strategy Training
- 2003
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Ingår i: Aging, Neuropsychology and Cognition. - : Routledge. - 1382-5585 .- 1744-4128. ; 10:3, s. 202-214
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Tidskriftsartikel (refereegranskat)abstract
- The effectiveness of two memory training programs designed to enhance four-digit number recall was examined in 90 healthy older adults. One group received instruction and training in the number-consonant mnemonic, whereas another group was instructed to adopt their own encoding and retrieval strategies to enhance number recall. Also, a control group receiving no training between testing occasions was included. The criterion task was administered according to the Buschke selective reminding procedure. Posttest performance was evaluated with and without cognitive support for remembering (i.e., verbal cues). Under unsupported conditions, the mnemonic group improved number recall following training and the selfgenerated strategy group showed a tendency in the same direction. When support was provided, group differences in favor of the two training groups increased. In addition, no training-related gains were observed in two verbal transfer tasks. The relatively similar patterns of gains in the two intervention groups were discussed in terms of advantages and disadvantages in the two training regimens balancing each other.
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| 8. |
- Fernaeus, Sven-Erik, et al.
(författare)
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Conceptual elaboration versus direct lexical access in WAIS-similarities : differential effects of white-matter lesions and gray matter volumes
- 2018
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Ingår i: Aging, Neuropsychology and Cognition. - : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 25:6, s. 893-903
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Tidskriftsartikel (refereegranskat)abstract
- Wechsler Adult Intelligence Scale (WAIS) subscale Similarities have been classified as a test of either verbal comprehension or of inductive reasoning. The reason may be that items divide into two categories. We tested the hypothesis of heterogeneity of items in WAIS-Similarities. Consecutive patients at a memory clinic and healthy controls participated in the study. White-matter hyperintensities (WMHs) and normalized temporal lobe volumes were measured based on Magnetic resonance Imaging (MRI), and tests of verbal memory and attention were used in addition to WAIS-Similarities to collect behavioural data. Factor analysis supported the hypothesis that two factors are involved in the performance of WAIS-similarities: (1) semiautomatic lexical access and (2) conceptual elaboration. These factors were highly correlated but provided discriminative diagnostic information: In logistic regression analyses, scores of the lexical access factor and of the conceptual elaboration factor discriminated patients with mild cognitive impairment from Alzheimer’s disease patients and from healthy controls, respectively. High scores of WMH, indicating periventricular white-matter lesions, predicted factor scores of direct lexical access but not those of conceptual elaboration, which were predicted only by medial and lateral temporal lobe volumes.
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| 9. |
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| 10. |
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| 11. |
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| 12. |
- Fällman, Katarina, 1984-, et al.
(författare)
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Normative data for the oldest old: Trail Making Test A, Symbol Digit Modalities Test, Victoria Stroop Test and Parallel Serial Mental Operations
- 2020
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Ingår i: Aging, Neuropsychology and Cognition. - : ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD. - 1382-5585 .- 1744-4128. ; 27:4, s. 567-550
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Tidskriftsartikel (refereegranskat)abstract
- Normative data for evaluating cognitive function in the oldest old, aged 85 years and above, are currently sparse. The normative values used in clinical practice are often derived from younger old persons, from small sample sizes or from broad age spans (e.g. amp;gt;75 years) resulting in a risk of misjudgment in assessments of cognitive decline. This longitudinal study presents normative values for the Trail Making Test A (TMT-A), the Symbol Digit Modalities Test (SDMT), the Victoria Stroop Test (VST) and the Parallel Serial Mental Operations (PaSMO) from cognitively intact Swedes aged 85 years and above. 207 participants, born in 1922, were tested at 85, 90 (n = 68) and 93 (n = 35) years of age with a cognitive screening test battery. The participants were originally recruited for participation in the Elderly in Linkoping Screening Assessment. Normative values are presented as mean values and standard deviations, with and without adjustment for education. There were no clinically important differences between genders, but education had a significant effect on test results for the 85-year-olds. Age effects emerged in analyses of those participants who completed the entire study and were evident for TMT-A, SDMT, VST1 and PaSMO. When comparisons can be made, our results are in accordance with previous data for TMT-A, SDMT and VST, and we present new normative values for PaSMO.
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| 13. |
- Habib, Reza, et al.
(författare)
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Cognitive and non-cognitive factors contributing to the longitudinal identification of successful older adults in the Betula study.
- 2007
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Ingår i: Aging, Neuropsychology and Cognition.. - Lisse : Swets & Zeitlinger. ; 14:3, s. 257-273
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Tidskriftsartikel (refereegranskat)abstract
- Studies of successful aging have typically defined elderly who fall in the upper end of a distribution of test scores as successful. A different definition of successful aging requires that older adults fall at or above the mean level of younger adults and maintain this level over time. Here we examined this definition of successful aging in a sample of 1463 individuals between 50 to 85 years of age. Based on principal coordinate analysis of cognitive and non-cognitive variables, we identified a group of 55 (8.3%) 70-85 years olds that were high functioning. This group of elderly showed elevated performance on a range of cognitive tasks. Non-cognitive factors that characterized this group included education and subjective health. The participants were re-tested 5 years later and the same type of analysis was repeated. Of the remaining individuals who initially were classified as high functioning, 18 (35%) remained high functioning and thus met the definition for successful aging. Years of education was a significant predictor of who remained successful over time.
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| 14. |
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| 15. |
- Hassing, L, et al.
(författare)
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Mortality-related differences and changes in episodic memory among the oldest old : evidence from a population-based sample of nonagenarians
- 2002
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Ingår i: Aging, Neuropsychology and Cognition. - : Taylor & Francis. - 1382-5585 .- 1744-4128. ; 9:1, s. 11-20
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Tidskriftsartikel (refereegranskat)abstract
- We examined cross-sectional differences and longitudinal changes in episodic memory performance related to impending death among a group of very old people, aged 90–101 years. Participants were assessed at 3 measurement points across a 6-year interval. Three groups were identified: those who survived the entire follow-up period (n =40), those who died before the first follow-up (n =44), and those who died after the first follow-up (n =14). Participants completed a battery of episodic memory tasks consisting of face recognition, word recognition, word recall, and object recall with selective reminding. Those who survived performed better than those who were going to die in object recall at baseline. A Cox regression analysis, controlling age, revealed that object recall performance was significantly related to subsequent mortality status. Longitudinal analyses demonstrated significant 3-year decline for both face recognition and object recall, but no evidence of differential decline as a function of mortality group. Thus, longitudinal changes in memory preceding death were not as pronounced as the corresponding cross-sectional differences in this very old sample. In general, the results suggest that mortality-related memory deficits are present in extreme old age, although these deficits are relatively small and task-specific.
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| 16. |
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| 17. |
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| 18. |
- Johansson, Maria M., et al.
(författare)
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Cognition, daily living, and health-related quality of life in 85-year-olds in Sweden
- 2012
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Ingår i: Aging, Neuropsychology and Cognition. - : Taylor & Francis. - 1382-5585 .- 1744-4128. ; 19:3, s. 421-432
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Tidskriftsartikel (refereegranskat)abstract
- This study investigates how cognition influences activities of daily living and health-related quality of life in 85-year-olds in Sweden (n = 373). Data collection included a postal questionnaire comprising demographics and health-related quality of life measured by the EQ-5D. The ability to perform personal activities of daily living (PADL) was assessed during a home visit that included administering the Mini Mental State Examination (MMSE). Cognitive impairment was shown in 108 individuals (29%). The majority were independent with respect to PADL. A larger number of participants with cognitive impairment reported that they needed assistance in instrumental activities of daily living (IADL) compared to the group without cognitive impairment. Impaired cognition was significantly related to problems with IADL. Significant but low correlations were found between cognition and health-related quality of life – higher ratings on perceived quality of life correlated with higher results on the MMSE.
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| 19. |
- Mattli, Florentina, et al.
(författare)
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Prospective memory across the lifespan : investigating the contribution of retrospective and prospective processes
- 2014
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Ingår i: Aging, Neuropsychology and Cognition. - : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 21:5, s. 515-543
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Tidskriftsartikel (refereegranskat)abstract
- Prospective memory performance follows an inverted U-shaped function across the lifespan. Findings on the relative contribution of purely prospective memory and retrospective memory processes within prospective memory to this trajectory are scarce and inconclusive. We analyzed age-related differences in prospective memory performance across the lifespan in a cross-sectional design including six age groups (N = 99, 7–83 years) and investigated possible mechanisms by experimentally disentangling the relative contributions of retrospective memory and purely prospective memory processes. Results confirmed the inverted U-shaped function of prospective memory performance across the lifespan. A significant interaction between process type and age group was observed indicating differential relative contributions of retrospective memory and purely prospective memory processes on the development of prospective memory performance. Our results showed that mainly the pure prospective memory processes within prospective memory lead to lower prospective memory performance in young children and old adults. Moreover, the relative contributions of the retrospective memory and purely prospective memory processes are not uniform at both ends of the lifespan, i.e., in later adulthood the purely prospective memory processes seem to determine performance to an even greater extent than in childhood. Nevertheless, age effects were also observed in the retrospective component which thus contributed to the prospective memory performance differences between the age groups.
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| 20. |
- Mäntylä, Timo, 1954-, et al.
(författare)
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Age differences in multiple outcome measures of time-based prospective memory
- 2009
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Ingår i: Aging, Neuropsychology and Cognition. - Oxford : Taylor and Francis Group. - 1382-5585 .- 1744-4128. ; 16:6, s. 708-720
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Tidskriftsartikel (refereegranskat)abstract
- This study examined time-based prospective memory performance in relation to age, monitoring strategy, response accuracy, and dual-task demands. Young, middle-aged and older adults (the passing of time every 5 min while listening to a short story (low task demands) or completing a series of cognitive tasks (high task demands). Young and older adults showed similar patterns of monitoring behavior, with low rates of clock checking during the early phase of each 5-min interval, followed by linearly accelerating monitoring functions. However, to obtain the same level of prospective memory performance older adults needed more frequent clock checks than young adults. Furthermore, older adults’ compensatory monitoring strategy was associated with an additional cost in primary task performance. Finally, increased primary task demands shifted age differences in prospective memory from monitoring frequency to response accuracy. These findings suggest that goal-directed behavior requires efficient task coordination and resource llocation, and that age-related differences in time-based prospective memory should be evaluated by using multiple outcome measures.
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| 21. |
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| 22. |
- Nilsson, Lars-Göran, et al.
(författare)
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Betula : a prospective cohort study on memory, health and aging
- 2004
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Ingår i: Aging, Neuropsychology and Cognition. - Hove : Psychology Press. - 1382-5585 .- 1744-4128. ; 11:2-3, s. 134-148
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Tidskriftsartikel (refereegranskat)abstract
- This article describes the Betula Study with respect to objectives, design, participants, and assessment instruments for health and cognition. Three waves of data collection have been completed in 5-year intervals since 1988-1990. A fourth wave started in 2003 and will be completed in 2005. An overview of Betula research is presented under the headings of memory and cognition and cognitive neuroscience. Health-related issues and sex differences as well as comparisons between cross-sectional and longitudinal studies are discussed in the first section. The influence of different genes and of some brain abnormalities for memory functioning in adulthood and old age constitute main topics in the second section. New data are presented on the association between blood pressure and dementia. We demonstrated that a demented group of participants had higher levels of systolic blood pressure and pulse pressure than non-dementia controls 10 years before diagnosis. The new fourth wave of data collection will, in addition to enriching the Betula database, permit revisiting and reanalyzing the existing data from new perspectives.
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| 23. |
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| 24. |
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| 25. |
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| 26. |
- Rosi, Alessia, et al.
(författare)
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Decision-making competence in younger and older adults : which cognitive abilities contribute to the application of decision rules?
- 2019
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Ingår i: Aging, Neuropsychology and Cognition. - : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 26:2, s. 174-189
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Tidskriftsartikel (refereegranskat)abstract
- Older adults perform worse than younger adults when applying decision rules to choose between options that vary along multiple attributes. Although previous studies have shown that general fluid cognitive abilities contribute to the accurate application of decision rules, relatively little is known about which specific cognitive abilities play the most important role. We examined the independent roles of working memory, verbal fluency, semantic knowledge, and components of executive functioning. We found that age-related decline in applying decision rules was statistically mediated by age-related decline in working memory and verbal fluency. Our results have implications for theories of aging and decision-making.
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| 27. |
- Rudner, Mary, et al.
(författare)
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Effects of Age on the Temporal Organization of Working Memory in Deaf Signers
- 2010
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Ingår i: AGING NEUROPSYCHOLOGY AND COGNITION. - : Taylor and Francis. - 1382-5585 .- 1744-4128. ; 17:3, s. 360-383
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Tidskriftsartikel (refereegranskat)abstract
- Deaf native signers have a general working memory (WM) capacity similar to that of hearing non-signers but are less sensitive to the temporal order of stored items at retrieval. General WM capacity declines with age, but little is known of how cognitive aging affects WM function in deaf signers. We investigated WM function in elderly deaf signers (EDS) and an age-matched comparison group of hearing non-signers (EHN) using a paradigm designed to highlight differences in temporal and spatial processing of item and order information. EDS performed worse than EHN on both item and order recognition using a temporal style of presentation. Reanalysis together with earlier data showed that with the temporal style of presentation, order recognition performance for EDS was also lower than for young adult deaf signers. Older participants responded more slowly than younger participants. These findings suggest that apart from age-related slowing irrespective of sensory and language status, there is an age-related difference specific to deaf signers in the ability to retain order information in WM when temporal processing demands are high. This may be due to neural reorganisation arising from sign language use. Concurrent spatial information with the Mixed style of presentation resulted in enhanced order processing for all groups, suggesting that concurrent temporal and spatial cues may enhance learning for both deaf and hearing groups. These findings support and extend the WM model for Ease of Language Understanding.
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| 28. |
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| 29. |
- Rönnlund, Michael, 1967-, et al.
(författare)
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Cross-Sectional versus Longitudinal Age Gradients of Tower of Hanoi Performance : The Role of Practice Effects and Cohort Differences in Education
- 2007
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Ingår i: Aging, Neuropsychology and Cognition. - : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 15:1, s. 40-67
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Tidskriftsartikel (refereegranskat)abstract
- We examined 5-year longitudinal changes in Tower of Hanoi (TOH) performance in a population-based sample of adults (35-85 years initially; n = 1480). An age-matched sample (n = 433) was included to estimate practice effects. The longitudinal age gradients differed substantially from the cross-sectional age gradients. This was the case even when practice effects, that were substantial in magnitude across the young/middle-aged groups, were controlled for. Instead of a continuous age-related deficit in performance from 35 and onwards, longitudinal data showed slowing of performance and increases of illegal moves past age 65. Cohort-related differences in educational attainment did not account for this discrepancy. Further analyses revealed a positive relation between practice-related gains and explicit memory of having performed the task at the first test occasion and a positive association between latent changes in TOH and Block Design, in line with cross-sectional findings. In conclusion, the results demonstrate a pattern of age-related changes indicating a late-onset decline of TOH performance and underscore the need to control for retest effects in longitudinal aging research.
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| 30. |
- Samrani, George, et al.
(författare)
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Proactive interference in working memory is related to adult age and cognitive factors : cross-sectional and longitudinal evidence from the Betula study
- 2021
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Ingår i: Aging, Neuropsychology and Cognition. - : Routledge. - 1382-5585 .- 1744-4128. ; 28:1, s. 108-127
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Tidskriftsartikel (refereegranskat)abstract
- In working memory (WM), successful maintenance of information is affected by interference. Older adults may be especially susceptible to the effects of interference, which may cause age-related cognitive impairments. A relative score of IC was derived from cross-sectional (n = 869) and longitudinal (n = 443) data to investigate (1) if IC is reduced in normal aging, (2) if individual differences in IC related to individual performance in other cognitive domains, and (3) if 5-year change in IC is related to change in general cognition. Older age was associated with reduced IC, but no decline in IC occurred over 5 years. Also, the ability to control interference in WM was related to performance in episodic memory, verbal fluency, and block design. We also found that IC mediates the relationship between age and cognition, suggesting that age-related cognitive decline is linked to IC. Finally, we demonstrate that change in IC was related to decline in episodic memory.
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| 31. |
- Sandberg, Petra, 1979-, et al.
(författare)
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Executive process training in young and old adults
- 2014
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Ingår i: Aging, Neuropsychology and Cognition. - : Taylor & Francis. - 1382-5585 .- 1744-4128. ; 21:5, s. 577-605
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Tidskriftsartikel (refereegranskat)abstract
- There is a growing body of research on the modifiability of executive functions in different stages of life. Previous studies demonstrate robust training effects but limited transfer in younger and particularly in older adults. The aim of the present study was to investigate whether a theoretically derived intervention for executive functioning, addressing several basic processes (updating, shifting, and inhibition), can induce transfer effects in early and late adulthood. Fifty-nine healthy adults, 29 young and 30 older adults, were randomly assigned to either training or no-contact control groups. The training groups received 15 sessions of executive process training for about 45 min/session during 5 weeks. A test battery including a criterion task and near, intermediate, and far transfer tasks was administered before and after training. Results showed pronounced age-equivalent gains on the criterion task. Near transfer was seen to non-trained updating and inhibition tasks for the young and older trained participants. However, only the young adults showed intermediate transfer to two complex working memory tasks. No far transfer effects were seen for either age group. These findings provide additional evidence for age-related constraints in the ability to generalize acquired executive skills, and specifically show that training of multiple executive processes is not sufficient to foster transfer beyond the very near in older adults.
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| 32. |
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| 33. |
- Stenling, Andreas, 1982-, et al.
(författare)
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Physical activity and cognitive function: between-person and within-person associations and moderators
- 2021
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Ingår i: Aging, Neuropsychology and Cognition. - : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 28:3, s. 392-417
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Tidskriftsartikel (refereegranskat)abstract
- In the present study, we decomposed between- and within-person effects and examined moderators of the longitudinal physical activity-cognition association. Participants (N = 1722) were drawn from the Betula study and we included four waves of data across 15 years. Bayesian multilevel modeling showed that self-reported physical activity did not predict changes in cognitive function. Physical activity positively predicted cognitive performance at baseline, and the relations were stronger for more active (compared to less active) older adults. Physical activity had a positive within-person effect on cognitive function. The within-person effect of physical activity on episodic memory recall was stronger for participants who on average engaged in less physical activity. The within-person effect on verbal fluency was stronger for participants with more education. Our results suggest that preserving cognitive functioning in old age might be more a matter of what you do in old age than reflecting what you did earlier in life.
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| 34. |
- Wehling, Eike Ines, et al.
(författare)
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Familiarity, cued and free odoridentification and their association with cognitive functioning in middleaged and older adults
- 2010
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Ingår i: Aging, Neuropsychology and Cognition. - : Psychology Press, Taylor and Francis Group. - 1382-5585 .- 1744-4128. ; 17:2, s. 205-219
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to examine the association between familiarity of odors, cued and free odor identification performance and cognitive function in elderly adults. It was further investigated how age affects performance on the various odor tasks. A third aim was to investigate the role of familiarity in explaining performance on the free identification task. One hundred and thirty-six participants (aged 45–79 years) with normal olfactory sensitivity were assessed with the Scandinavian Odor Identification Test (SOIT) and standardized tests of cognitive function. Familiarity did not correlate with any measure of cognitive function, while verbal identification performance was associated with several cognitive measures, although correlations were modest. In this sample, free odor identification was affected by increasing age to a marginally larger extent than cued identification performance and familiarity ratings. The results suggest that the different olfactory tasks involve different levels of cognitive processing.
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| 35. |
- Yonker, Julie E, et al.
(författare)
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Verified hormone therapy improves episodic memory performance in healthy postmenopausal women.
- 2006
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Ingår i: Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. - Hove : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 13:3-4, s. 291-307
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Tidskriftsartikel (refereegranskat)abstract
- Studies of hormone therapy (HT) and cognition have yielded conflicting results. The aim of this observational study was to examine the effect of estradiol, via serum verified HT (estradiol, estriol, progesterone) and endogenous estradiol, on 108 healthy postmenopausal women's cognitive performance. The results demonstrated that the 43 HT-users performed at a significantly higher level than non-users on episodic memory tasks and on a verbal fluency task, whereas HT-users and non-users did not differ on tasks assessing semantic memory and spatial visualization. In addition, there was a positive relationship between serum estradiol level and episodic memory performance, indicating that postmenopausal HT is associated with enhanced episodic memory and verbal fluency, independent of age and education. These observational results suggest that HT use may be sufficient to exert small, yet positive effects on female sensitive cognitive tasks. Hormone therapy compliance and formulation is discussed as confounding factors in previous research.
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| 36. |
- Ziaei, Maryam, et al.
(författare)
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Neural correlates of affective empathy in aging : A multimodal imaging and multivariate approach
- 2022
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Ingår i: Aging, Neuropsychology and Cognition. - : Routledge. - 1382-5585 .- 1744-4128. ; 29:3, s. 577-598
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Tidskriftsartikel (refereegranskat)abstract
- Empathy is one such social-cognitive capacity that undergoes age-related change. C urrently, however, not well understood is the structural and functional neurocircuitry underlying age-related differences in empathy. This study aimed to delineate brain structural and functional networks that subserve affective empathic response in younger and older adults using a modified version of the Multifaceted Empathy Task to both positive and negative emotions. Combining multimodal neuroimaging with multivariate partial least square analysis resulted in two novel findings in older but not younger adults: (a) faster empathic responding to negative emotions was related to greater fractional anisotropy of the anterior cingulum and greater functional activity of the anterior cingulate network; (b) however, empathic responding to positive emotions was related to greater fractional anisotropy of the posterior cingulum and greater functional activity of the posterior cingulate network. Such differentiation of structural and functional networks might have critical implications for prosocial behavior and social connections among older adults.
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| 37. |
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| 38. |
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| 39. |
- Nilsson, Lars-Göran, et al.
(författare)
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Cognitive test battery of CASCADE : Tasks and data.
- 2005
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Ingår i: Aging, Neuropsychology and Cognition. - 1382-5585. ; 12:1, s. 32-56
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the cognitive test battery used in the CASCADE Study (Cardiovascular Determinants of Dementia) for examining the consequences of cerebral white matter lesions and atrophy. The test battery includes nine different tasks assessing memory, executive function, and global cognitive function. Three episodic memory tasks were used in combinations to assess the role of attention and speed on encoding. Estimates of short- and long-term memory capacity were also derived from these three memory tasks. Semantic memory production / frontal lobe functions were assessed by means of a word fluency test. The Letter Digit Substitution test and the Stroop test were used to assess speed of processing and attention. Motor speed was measured with the Purdue Pegboard test, and global cognitive function was assessed by the Mini Mental State Examination. Overall performance data for the whole CASCADE sample and for each of eight study centers are presented for each test. Possible reasons for performance differences among study centers are discussed.
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