| 1. |
- Andersson, Jan O, 1971-
(författare)
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Double peaks reveal rare diplomonad sex
- 2012
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Ingår i: Trends in Parasitology. - : Elsevier BV. - 1471-4922 .- 1471-5007. ; 28:2, s. 46-52
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Tidskriftsartikel (refereegranskat)abstract
- Diplomonads, single-celled eukaryotes, are unusual in having two nuclei. Each nucleus contains two copies of the genome and is transcriptionally active. It has long been assumed that diplomonads in general and Giardia intestinalis in particular are asexual. Genomic and population genetic data now challenge that assumption and extensive allelic sequence heterogeneity has been reported in some but not all examined diplomonad lineages. Here it is argued, in contrast to common assumptions, that allelic differences indicate recent sexual events, and isolates that have divided asexually for many generations have lost their allelic variation owing to within-cell recombination. Consequently, directed studies of the allelic sequence heterogeneity in diverse diplomonad lineages are likely to reveal details about the enigmatic diplomonad sexual life cycle.
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| 2. |
- Bensch, Staffan, et al.
(författare)
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How can we determine the molecular clock of malaria parasites?
- 2013
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Ingår i: Trends in Parasitology. - : Elsevier BV. - 1471-5007 .- 1471-4922. ; 29:8, s. 363-369
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Forskningsöversikt (refereegranskat)abstract
- The association of contemporary hosts and their parasites might reflect either cospeciation or more recent shifts among existing hosts. Cospeciation implies that lineages of hosts and parasites diverge in parallel at the same time, but testing this prediction requires time-calibrated phylogenies, which are particularly difficult to obtain in organisms that leave few fossils. It has successively become clear that host shifts have been frequent in the evolutionary history of malaria parasites, but dating these host shifts cannot be done without calibrated phylogenies. Hence, it remains unresolved how long contemporary hosts and vectors have been coevolving with their malaria parasites. This review addresses conflicting rate estimates of molecular evolution and suggests research directions to aid dating diversification events in malaria parasites.
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| 3. |
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| 4. |
- Chookajorn, Thanat, et al.
(författare)
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Sideways : road to gene-by-gene functional screening in malaria parasites
- 2023
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Ingår i: Trends in Parasitology. - : CellPress. - 1471-4922 .- 1471-5007. ; 39:5, s. 317-318
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide screening in apicomplexan species has transformed our understanding of these parasitic protozoa. Kimmel et al. report a 'knock sideways' system and provide a powerful use case for its feasibility in a gene-by-gene screening in Plasmodium falciparum. Carefully deployed, a novel toolkit helps to dissect the biological uniqueness of an important parasite.
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| 5. |
- Doerig, Christian, et al.
(författare)
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Protein kinases of malaria parasites : an update
- 2008
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Ingår i: Trends in Parasitology. - : Elsevier. - 1471-4922 .- 1471-5007. ; 24:12, s. 570-577
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Tidskriftsartikel (refereegranskat)abstract
- Protein kinases (PKs) play crucial roles in the control of proliferation and differentiation in eukaryotic cells. Research on protein phosphorylation has expanded tremendously in the past few years, in part as a consequence of the realization that PKs represent attractive drug targets in a variety of diseases. Activity in Plasmodium PK research has followed this trend, and several reports on various aspects of this subject were delivered at the Molecular Approaches to Malaria 2008 meeting (MAM2008), a sharp increase from the previous meeting. Here, the authors of most of these communications join to propose an integrated update of the development of the rapidly expanding field of Plasmodium kinomics.
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| 6. |
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| 7. |
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| 8. |
- Hildebrandt, Franziska, et al.
(författare)
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Delineating Plasmodium liver infection across space and time
- 2023
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Ingår i: Trends in Parasitology. - : Elsevier. - 1471-4922 .- 1471-5007. ; 39:2, s. 80-82
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The liver is a major entry point and gatekeeper for invasive pathogens. However, high-resolution, spatiotemporal transcriptomic analysis of host-pathogen interactions has remained challenging. Afriat et al. have deconvoluted Plasmodium berghei liver-stage maturation at an unprecedented scale and discovered molecular signatures of heterogeneity during pre-erythrocytic development of malarial parasites.
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| 9. |
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| 10. |
- Höglund, Johan
(författare)
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100 Questions in Livestock Helminthology Research
- 2019
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Ingår i: Trends in Parasitology. - : Elsevier BV. - 1471-4922 .- 1471-5007. ; 35, s. 52-71
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Forskningsöversikt (refereegranskat)abstract
- An elicitation exercise was conducted to collect and identify pressing questions concerning the study of helminths in livestock, to help guide research priorities. Questions were invited from the research community in an inclusive way. Of 385 questions submitted, 100 were chosen by online vote, with priority given to open questions in important areas that are specific enough to permit investigation within a focused project or programme of research. The final list of questions was divided into ten themes. We present the questions and set them briefly in the context of the current state of knowledge. Although subjective, the results provide a snapshot of current concerns and perceived priorities in the field of livestock helminthology, and we hope that they will stimulate ongoing or new research efforts.
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| 11. |
- Miller, Kirsten
(författare)
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A dearth of data: fitting parasitoids into ecological networks
- 2021
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Ingår i: Trends in Parasitology. - : Elsevier BV. - 1471-4922 .- 1471-5007. ; 37, s. 863-874
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Tidskriftsartikel (refereegranskat)abstract
- Studying parasitoids can provide insights into global diversity estimates, climate change impacts, and agroecosystem service provision. However, this potential remains largely untapped due to a lack of data on how parasitoids interact with other organisms. Ecological networks are a useful tool for studying and exploiting the impacts of parasitoids, but their construction is hindered by the magnitude of undescribed parasitoid species, a sparse knowledge of host ranges, and an under-representation of parasitoids within DNA-barcode databases (we estimate <5% have a barcode). Here, we advocate the use of DNA metabarcoding to construct the host-parasitoid component of multilayer networks. While the incorporation of parasitoids into network-based analyses has far ranging applications, we focus on its potential for assessing ecosystem service provision within agroecosystems.
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| 12. |
- Morrison, David
(författare)
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Evolution of the Apicomplexa: where are we now?
- 2009
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Ingår i: Trends in Parasitology. - : Elsevier BV. - 1471-4922 .- 1471-5007. ; 25, s. 375-382
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Forskningsöversikt (refereegranskat)abstract
- The Apicomplexa is the only large taxonomic group whose members are entirely parasitic and is, therefore, presumably of major interest to parasitologists. We might, for example, expect that we know a great deal about the biology of the group by now and that we have a clear phylogenetic framework within which to organize that knowledge. It might thus come as a surprise to learn that in terms of biodiversity, the Apicomplexa is actually the least-known group of all. Furthermore, the taxonomic framework for the Apicomplexa is rather tenuous in many respects. This situation is unlikely to change in the short term.
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| 13. |
- Perez-Tris, Javier, et al.
(författare)
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What are malaria parasites?
- 2005
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Ingår i: Trends in Parasitology. - : Elsevier BV. ; 21:5, s. 209-211
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Tidskriftsartikel (refereegranskat)
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| 14. |
- Rodrigues De Miranda, Joachim, et al.
(författare)
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Varroa destructor: A Complex Parasite, Crippling Honey Bees Worldwide
- 2020
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Ingår i: Trends in Parasitology. - : Elsevier BV. - 1471-4922 .- 1471-5007. ; 36, s. 592-606
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Forskningsöversikt (refereegranskat)abstract
- The parasitic mite, Varroa destructor, has shaken the beekeeping and pollination industries since its spread from its native host, the Asian honey bee (Apis cerana), to the naive European honey bee (Apis mellifera) used commercially for pollination and honey production around the globe. Varroa is the greatest threat to honey bee health. Worrying observations include increasing acaricide resistance in the varroa population and sinking economic treatment thresholds, suggesting that the mites or their vectored viruses are becoming more virulent. Highly infested weak colonies facilitate mite dispersal and disease transmission to stronger and healthier colonies. Here, we review recent developments in the biology, pathology, and management of varroa, and integrate older knowledge that is less well known.
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| 15. |
- Rojas-Lopez, Laura, et al.
(författare)
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Giardia duodenalis
- 2022
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Ingår i: Trends in Parasitology. - : Elsevier. - 1471-4922 .- 1471-5007. ; 38:7, s. 605-606
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 16. |
- Ross, Emily Charlotte, 1991-, et al.
(författare)
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Early passage of Toxoplasma gondii across the blood–brain barrier
- 2022
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Ingår i: Trends in Parasitology. - : Elsevier BV. - 1471-4922 .- 1471-5007. ; 38:6, s. 450-461
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Forskningsöversikt (refereegranskat)abstract
- The blood–brain barrier (BBB) efficiently protects the central nervous system (CNS) from infectious insults. Yet, the apicomplexan parasite Toxoplasma gondii has a remarkable capability to establish latent cerebral infection in humans and other vertebrates. In addition to the proposed mechanisms for access to the brain parenchyma, recent findings highlight a paramount role played by the BBB in restricting parasite passage and minimizing parasite loads in the brain. Consistent with clinically asymptomatic primary infections in humans, mounting evidence indicates that the original colonization of the brain by T. gondii encompasses previously unappreciated, nondisruptive translocation processes that precede the onset of parasite-limiting immune responses.
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| 17. |
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| 19. |
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| 20. |
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| 21. |
- Yañez, Orlando, et al.
(författare)
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Varroa invasion and virus adaptation.
- 2012
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Ingår i: Trends in Parasitology. - : Elsevier BV. - 1471-4922 .- 1471-5007. ; 28, s. 353-354
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Annan publikation (refereegranskat)
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| 22. |
- Bensch, Staffan, et al.
(författare)
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Brain parasites and misorientation of migratory birds
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Ingår i: Trends in Parasitology. - 1471-4922.
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Tidskriftsartikel (refereegranskat)abstract
- Haemoproteus blood parasites of birds are thought to be relatively benign. Recent findings show that infections may develop in the brain of birds, possibly distorting their orientation sense. Misdirected migration may lead migrants outside their range where they are recognized as vagrants and can transmit parasites to novel hosts.
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| 23. |
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| 24. |
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| 25. |
- Martínez-de la Puente, Josué, et al.
(författare)
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Plasmodium relictum
- 2021
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Ingår i: Trends in Parasitology. - : Elsevier BV. - 1471-4922. ; 37:4, s. 355-356
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Forskningsöversikt (refereegranskat)
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| 26. |
- Roxström-Lindquist, Katarina, et al.
(författare)
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Giardia immunity--an update.
- 2006
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Ingår i: Trends Parasitol. - : Elsevier BV. - 1471-4922. ; 22:1, s. 26-31
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 27. |
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