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- Helms, Gunther, et al.
(författare)
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Resampling Strategies to Estimate Mean Concentrations from Low SNR In Vivo MR Spectra
- 2007
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Ingår i: Proc. Intl. Soc. Mag. Reson. Med.. - 1524-6965 .- 1524-6965. ; 15
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Konferensbidrag (refereegranskat)abstract
- A resampling method for quantitative MRS is presented that retains absolute concentrations. Averaging the spectra from a subset improved the concentrationestimates via increased SNR. Using short-TE STEAM spectra from human thalamus, the influence of subset size was systematically studied and verifiedagainst conventional bootstrap re-sampling. Even small subsets provided considerably better signal-to-noise ratio and reliability. The standard deviation orconfidence intervals can be derived by correcting the variance over all subset estimates for the inherent redundancy. Subsets of about half the group size arerecommended, because of their large number and the almost normal distribution of mean concentration estimates.
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