| 1. |
- Klefsjö, Bengt
(författare)
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Some tests against aging based on the total time on test transform
- 1983
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Ingår i: Communications in Statistics - Theory and Methods. - : Informa UK Limited. - 0361-0926 .- 1532-415X. ; 12:8, s. 907-927
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Tidskriftsartikel (refereegranskat)abstract
- Let F be a life distribution with survival function = 1 - F and finite mean The scaled total time on test transform was introduced by Barlow and Campo (1975) as a tool in the statistical analysis of life data. The aging properties IFR, IFRA, NBUE and DMRL can be translated to properties of ϕF(t). Guided by these properties of ϕF(t) we suggest some test statistics for testing exponentiality against IFR, IFRA, NBUE and DMRL, respectively. The IFR and IFRA tests are new; the NBUE and DMRL tests have already been proposed and stu- died by Hollander and Proschan (1975) . The exact and asymptotic distributions of the statistics are derived and the asymptotic efficiencies of the tests are studied. The power of some tests is estimated by simulation for some alternatives when the sample size is n = 10 or n = 20.
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| 2. |
- Burdakov, Oleg, 1953-
(författare)
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Methods of the secant type for systems of equations with symmetric Jacobian matrix
- 1983
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Ingår i: Numerical Functional Analysis and Optimization. - : Taylor & Francis. - 0163-0563 .- 1532-2467. ; 6:2, s. 183-195
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Tidskriftsartikel (refereegranskat)abstract
- Symmetric methods (SS methods) of the secant type are proposed for systems of equations with symmetric Jacobian matrix. The SSI and SS2 methods generate sequences of symmetric matrices J and H which approximate the Jacobian matrix and inverse one, respectively. Rank-two quasi-Newton formulas for updating J and H are derived. The structure of the approximations J and H is better than the structure of the corresponding approximations in the traditional secant method because the SS methods take into account symmetry of the Jacobian matrix. Furthermore, the new methods retain the main properties of the traditional secant method, namely, J and H-1are consistent approximations to the Jacobian matrix; the SS methods converge superlinearly; the sequential (n + 1)-point SS methods have the R-order at least equal to the positive root of tn+1-tn-1=0.
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| 3. |
- Gardeström, Per, 1950-, et al.
(författare)
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Isolation of Mitochondria from Leaf Tissue of Panicum miliaceum, a NAD-Malic Enzyme Type C(4) Plant.
- 1983
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Ingår i: Plant Physiology. - 0032-0889 .- 1532-2548. ; 71:1, s. 24-9
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Tidskriftsartikel (refereegranskat)abstract
- A mechanical isolation procedure was developed to study the respiratory properties of mitochondria from the mesophyll and bundle sheath tissue of Panicum miliaceum, a NAD-malic enzyme C(4) plant. A mesophyll fraction and a bundle sheath fraction were obtained from young leaves by differential mechanical treatment. The purity of both fractions was about 80%, based on analysis of the cross-contamination of ribulose bisphosphate carboxylase activity and phosphoenolpyruvate carboxylase activity.Mitochondria were isolated from the two fractions by differential centrifugation and Percoll density gradient centrifugation. The enrichment of mitochondria relative to chloroplast material was about 75-fold in both preparations.Both types of mitochondria oxidized NADH and succinate with respiratory control. Malate oxidation in mesophyll mitochondria was sensitive to KCN and showed good respiratory control. In bundle sheath mitochondria, malate oxidation was largely insensitive to KCN and showed no respiratory control. The oxidation was strongly inhibited by salicylhydroxamic acid, showing that the alternative oxidase was involved. The bundle sheath mitochondria of this type of C(4) species contribute to C(4) photosynthesis through decarboxylation of malate. Malate oxidation linked to an uncoupled, alternative pathway may allow decarboxylation to proceed without the restraints which might occur via coupled electron flow through the cytochrome chain.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
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| 8. |
- Stubbe, Ingo, et al.
(författare)
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Plasma lipoproteins and lipolytic enzyme activities during endurance training in sedentary men: changes in high-density lipoprotein subfractions and composition
- 1983
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Ingår i: Metabolism, Clinical and Experimental. - : Elsevier BV. - 1532-8600. ; 32:12, s. 1120-1128
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Tidskriftsartikel (refereegranskat)abstract
- Eighteen healthy sedentary males took part in supervised bicycle training for 50 minutes three to five times a week. Twelve subjects (group A) trained for 6 weeks at heavy intensity, and six subjects (group B) trained for 12 weeks at moderate intensity. Maximal oxygen uptake increased by about 20% (P less than 0.01). Body weight and composition as well as diet remained unchanged. After 6 weeks plasma high-density lipoprotein (HDL) cholesterol concentrations had increased by 7% (P less than 0.05) in all subjects. The increase was most marked in group B at 14% (P less than 0.05) compared to 3% in group A (ns). Apolipoprotein AI (apo AI) increased by about 7% in both groups (P less than 0.01). After 12 weeks HDL cholesterol and apo AI levels had almost returned to initial values. Measurements of HDL components showed increases of 6% to 12% in free cholesterol, cholesteryl ester (P less than 0.05), and phospholipid (P less than 0.01); whereas, the minor triglyceride fraction decreased by 20% (P less than 0.01). Zonal ultracentrifugation in four subjects revealed a preferential rise of about 35% in the HDL2 subfraction, increasing the HDL2/HDL3 ratio by about 20%. In parallel, the composition of the lipoprotein classes changed. The protein moiety of all classes, except low-density lipoprotein (LDL), expanded at the expense of the core components cholesteryl ester and triglyceride. Hepatic lipase (HL) activity decreased by 6% (P less than 0.05), and lipoprotein lipase (LPL) activity in adipose tissue increased by about 50% (P less than 0.05) during the first 6 weeks of training, while LPL activity in postheparin plasma and skeletal muscle did not change. The transient rise in HDL cholesterol levels was correlated (P less than 0.05) to the elevation of adipose tissue LPL activity. The alterations in HDL concentration were also related to changes in body composition and diet, especially to an increase in fat intake.
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| 9. |
- Liljeberg, Evelina, 1985-, et al.
(författare)
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Incomplete descriptions of oral nutritional supplement interventions in reports of randomised controlled trials
- 2018
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Ingår i: Clinical Nutrition. - : Elsevier. - 0261-5614 .- 1532-1983. ; 37:1, s. 61-71
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Tidskriftsartikel (refereegranskat)abstract
- Background & aimsThe effects of oral nutritional supplements (ONS) have been evaluated in several clinical trials and more studies have been requested. To facilitate replication, support accurate evaluations of research results and avoid research waste, high quality reporting of interventions in clinical trials is needed. The aim of this study is to assess the quality of reporting of interventions in publications describing randomised controlled trials of ONS in populations with malnutrition or at nutritional risk.MethodsThe PubMed database was searched for articles describing ONS trials published between January 2002 and December 2015. The quality of intervention descriptions was evaluated using the Template for Intervention Description and Replication (TIDieR) checklist and guide, which contains twelve items. Articles published before and after 2011 were compared.ResultsOf 76 articles identified, only 3% reported all TIDieR items in sufficient detail. The most frequently missing elements were descriptions of the intervention procedures (e.g. how the ONS were to be taken and if participants were given a choice of flavours), which were adequately presented in only 26% of the articles. Less than half of the articles included a description of the intervention provider and sufficient information about the location(s) for the intervention. Information about adherence and mode of delivery was reported in 60–65% of the articles. Most frequently reported, in >70% of the articles, were items regarding the brief name of the intervention, the rationale for the intervention and the materials used (i.e. information about the specific ONS product(s) administered). The reporting quality for two of the items (materials and provider) was higher in articles published after 2011.ConclusionsThe quality of reporting of ONS interventions was found to be poor. The descriptions mostly lacked information about intervention procedures, provider and location(s). A moderately higher reporting quality was observed in articles published after 2011. These findings imply that an improvement in the descriptions of ONS interventions is required in future clinical trials of malnutrition treatment.
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| 10. |
- Ashfaq, Awais, 1990-, et al.
(författare)
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Readmission prediction using deep learning on electronic health records
- 2019
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Ingår i: Journal of Biomedical Informatics. - Maryland Heights, MO : Elsevier BV. - 1532-0464 .- 1532-0480. ; 97
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Tidskriftsartikel (refereegranskat)abstract
- Unscheduled 30-day readmissions are a hallmark of Congestive Heart Failure (CHF) patients that pose significant health risks and escalate care cost. In order to reduce readmissions and curb the cost of care, it is important to initiate targeted intervention programs for patients at risk of readmission. This requires identifying high-risk patients at the time of discharge from hospital. Here, using real data from over 7500 CHF patients hospitalized between 2012 and 2016 in Sweden, we built and tested a deep learning framework to predict 30-day unscheduled readmission. We present a cost-sensitive formulation of Long Short-Term Memory (LSTM) neural network using expert features and contextual embedding of clinical concepts. This study targets key elements of an Electronic Health Record (EHR) driven prediction model in a single framework: using both expert and machine derived features, incorporating sequential patterns and addressing the class imbalance problem. We evaluate the contribution of each element towards prediction performance (ROC-AUC, F1-measure) and cost-savings. We show that the model with all key elements achieves higher discrimination ability (AUC: 0.77; F1: 0.51; Cost: 22% of maximum possible savings) outperforming the reduced models in at least two evaluation metrics. Additionally, we present a simple financial analysis to estimate annual savings if targeted interventions are offered to high risk patients. © 2019 The Authors
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| 11. |
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| 12. |
- Bergquist, Magnus, 1983
(författare)
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Most People Think They Are More Pro-Environmental than Others: A Demonstration of the Better-than-Average Effect in Perceived Pro-Environmental Behavioral Engagement
- 2020
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Ingår i: Basic and Applied Social Psychology. - : Informa UK Limited. - 0197-3533 .- 1532-4834. ; 42:1, s. 50-61
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Tidskriftsartikel (refereegranskat)abstract
- People tend to perceive themselves as better than average in various contexts. In this article I test if the better-than-average effect (BTAE) also holds for pro-environmental behavioral engagement. Experiment 1 supported that the majority of participants report to be more pro-environmental than others, using a large representative sample. Experiment 2 validated these findings in 3 additional cultures (United States, United Kingdom, and India) and showed that BTAE held for both abstract (other Americans) and concrete (my friends) comparisons. Experiment 3 found that participants overestimated both how "much" and how "often" they engage in pro-environmental actions. Finally, Experiment 4 found weak support for the hypothesis that inducing BTAE are inhibiting future pro-environmental behaviors.
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| 13. |
- Edlund, Sara, 1983-, et al.
(författare)
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Facing negative emotions : Evaluation of a brief training in validating communication for contact nurses in cancer care
- 2023
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Ingår i: European Journal of Oncology Nursing. - : Elsevier. - 1462-3889 .- 1532-2122. ; 66
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Tidskriftsartikel (refereegranskat)abstract
- Background: Contact nurses in cancer care (CNCC) often face challenges when communicating with patients and their families. The overall aim was to evaluate a brief digital validation training for CNCC, to test whether it was associated with increased validation and decreased invalidation. Associations between communication skills in validation and markers of work-related stress were also investigated. Methods: This intervention study investigated associations between the training and validation skills using a within-group design with repeated measures (at pre, post, and eight-week follow-up). Additionally, associations between the training and occupational self-efficacy, self-validation, and exhaustion symptoms were explored. Results: Seventeen CNCCs (all female with relatively long work experience) completed a five-week digital training program. Results indicated a statistically significant increase in validation and a statistically significant decrease in invalidation, showing that the nurses improved their communication skills following the training. No changes were found in markers of work-related stress. Conclusion: The results indicate that digital validation training for CNCCs is potentially beneficial by means of improving communication skills. This study further demonstrates that a brief digital training in validating communication to CNCC is associated with improved person-centered communication regarding strong negative emotions.
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| 14. |
- Eman, Josefin, 1983-
(författare)
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The complexity of physical capital : How old male athletes relate to body and health
- 2013
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Ingår i: International Journal of Men's Health. - : Men's Studies Press. - 1532-6306 .- 1933-0278. ; 12:1, s. 29-41
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present article was to explore how a relatively privileged group of old men, e.g. old athletes, relate to their bodies and health in the process of growing old. Ten male athletes from 68 to 90 years of age were interviewed in this grounded theory study. The findings suggest that the old male athletes controlled their bodies in order to gain physical capital, but that different ways of employing the body were valued in different contexts. Three such contexts were identified: the aging, athletic and masculine context. In an aging context, the men emphasized the importance of caring for one’s body and health, but in an athletic and masculine context, they expressed both a caring and a non-caring approach to body and health. In other words, on the whole the men displayed a contradictious way of relating to their bodies and health. However, they could to some extent reconcile the tensions between the different norms of body and health by emphasizing the need to preserve physical autonomy, an ideal that appeared to be valid in all three contexts.
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| 15. |
- Engqvist, Martin, 1983, et al.
(författare)
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Applications of protein engineering and directed evolution in plant research
- 2019
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Ingår i: Plant Physiology. - : Oxford University Press (OUP). - 1532-2548 .- 0032-0889. ; 179:3, s. 907-917
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Tidskriftsartikel (refereegranskat)abstract
- Protein engineering and directed evolution are powerful technologies for probing protein sequencefunction relationships. Thesemethods have been used to engineer both plant-derived proteins and exogenous proteins heterologously expressed in plants. In this review, we aim to further increase the interdisciplinary crossover between the disciplines of protein engineering and plant biology by first introducing protein engineering in some detail. This introduction is key to understanding current limitations to protein engineering when applied to plants. Subsequently, we provide an overview of the recent methodological progress in, and novel applications of, protein engineering and directed evolution in plant research.
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| 16. |
- Engqvist, Martin, 1983, et al.
(författare)
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GLYCOLATE OXIDASE3, a Glycolate Oxidase Homolog of Yeast l-Lactate Cytochrome c Oxidoreductase, Supports l-Lactate Oxidation in Roots of Arabidopsis
- 2015
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Ingår i: Plant Physiology. - : Oxford University Press (OUP). - 1532-2548 .- 0032-0889. ; 169:2, s. 1042-1061
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Tidskriftsartikel (refereegranskat)abstract
- In roots of Arabidopsis (Arabidopsis thaliana), L-lactate is generated by the reduction of pyruvate via L-lactate dehydrogenase, but this enzyme does not efficiently catalyze the reverse reaction. Here, we identify the Arabidopsis glycolate oxidase (GOX) paralogs GOX1, GOX2, and GOX3 as putative L-lactate-metabolizing enzymes based on their homology to CYB2, the L-lactate cytochrome c oxidoreductase from the yeast Saccharomyces cerevisiae. We found that GOX3 uses L-lactate with a similar efficiency to glycolate; in contrast, the photorespiratory isoforms GOX1 and GOX2, which share similar enzymatic properties, use glycolate with much higher efficiencies than L-lactate. The key factor making GOX3 more efficient with L-lactate than GOX1 and GOX2 is a 5- to 10-fold lower Km for the substrate. Consequently, only GOX3 can efficiently metabolize L-lactate at low intracellular concentrations. Isotope tracer experiments as well as substrate toxicity tests using GOX3 loss-offunction and overexpressor plants indicate that L-lactate is metabolized in vivo by GOX3. Moreover, GOX3 rescues the lethal growth phenotype of a yeast strain lacking CYB2, which cannot grow on L-lactate as a sole carbon source. GOX3 is predominantly present in roots and mature to aging leaves but is largely absent from young photosynthetic leaves, indicating that it plays a role predominantly in heterotrophic rather than autotrophic tissues, at least under standard growth conditions. In roots of plants grown under normoxic conditions, loss of function of GOX3 induces metabolic rearrangements that mirror wild-type responses under hypoxia. Thus, we identified GOX3 as the enzyme that metabolizes L-lactate to pyruvate in vivo and hypothesize that it may ensure the sustainment of low levels of L-lactate after its formation under normoxia.
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| 17. |
- Gyberg, Fanny, 1983, et al.
(författare)
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"Being stuck between two worlds": Identity configurations of occupational and family identities.
- 2019
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Ingår i: Identity. An International Journal of Theory and Research. - : Informa UK Limited. - 1528-3488 .- 1532-706X. ; 19:4, s. 330-446
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Tidskriftsartikel (refereegranskat)abstract
- Most research on identity has focused on either identity processes or identity content, neglecting how individuals structure their identities. We investigated how individuals negotiated their sometimes conflicting multiple identifications of work and family into different types of workable identity configurations. We also examined differences across configurations in the gender distribution, degree of conflict, and life satisfaction. Through a mixed methods approach, a community sample of 124 young Swedish adults (50% women, Mage 33.29 years) were interviewed about work and family priorities and completed a rating scale measure of life satisfaction. The qualitative analyses showed six different types of identity configurations, the most common being Family first, followed by Everything is important, Struggling to prioritize, Now family comes first, Inability to prioritize, and Work first. The quantitative analyses showed few gender differences across configurations, but there were differences in conflict and life satisfaction between configurations. The findings from this study reflect the complex and dynamic ways identity is structured within a cultural context.
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| 18. |
- Gyberg, Fanny, 1983, et al.
(författare)
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Identity Status, Gender, and Social Comparison Among Young Adults
- 2017
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Ingår i: Identity - An International Journal of Theory and Research. - : Informa UK Limited. - 1528-3488 .- 1532-706X. ; 17:4, s. 239-252
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate identity status globally and across identity domains among young Swedish adult women and men. Also, potential differences in social comparison among identity statuses were evaluated. The results showed that most of the 124 participants (50% women, Mage 33.29years) were assigned to an achieved global identity and had made identity-defining commitments across domains. Gender differences in identity status were found in the occupational and parenthood domains. In addition, differences in social comparison orientation were found only in the parenthood domain, whereas those assigned to moratorium scored higher in social comparison than did those assigned to foreclosure and diffusion. These results bring important knowledge to our understanding of identity during young adulthood.
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| 19. |
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| 20. |
- Kolavali, Reddysuresh, 1983, et al.
(författare)
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The sorption of monovalent cations onto norway spruce: Model studies using wood flour and LiCl solution
- 2017
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Ingår i: Journal of Wood Chemistry and Technology. - : Informa UK Limited. - 1532-2319 .- 0277-3813. ; 37:2, s. 110-123
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Tidskriftsartikel (refereegranskat)abstract
- The transport of chemicals in a porous material such as wood is very complex and involves several processes: the diffusion of chemicals in the cell pores (lumen and pit pores), through the cell walls at certain conditions, and sorption of wood tissue. In the present study, batch sorption experiments were performed to examine the sorption of Li+ ions from an aqueous LiCl solution onto Norway spruce wood flour samples. The experimental methodology employed is suitable for differentiating the amount of ions sorbed onto the wood tissue and dissolved in the solution in wood pores. The apparent equilibrium sorption data were analyzed using two widely applied isotherm models: Langmuir and Freundlich. The results suggest that the sorption was spontaneous, and for the experimental conditions studied, probably involved several interaction types between the different functional groups of the wood and the Li+/Cl− ions.
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| 21. |
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| 22. |
- Marušić, Branka, 1983-
(författare)
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The concept of terroir tested : sharing of the same terroir between two EU Member States
- 2021
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Ingår i: Journal of Intellectual Property Law & Practice. - : Oxford University Press (OUP). - 1747-1532 .- 1747-1540. ; 16:4-5, s. 435-441
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Tidskriftsartikel (refereegranskat)abstract
- This article looks into wine as a credence product, whose bond of trust is vested in the concept of terroir as a signal to the consumer that the wine she or he is buying originates from a specific location and is made in specific circumstances. The main question of the present analysis is what the legal consequences are when such terroir is shared between two EU Member States, looking into the examples of wines Tokaj and Teran.Arguments advanced in the article are that, on the EU-wide level, there are two effects of the shared terroir. The first effect is a shared PDO; and the second effect is an artificial enlargement of terroir that is not linked to the original geographical position.
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| 23. |
- Marušić, Branka, 1983-
(författare)
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The implementation of Article 15 of the DSM Directive in Croatia : a gold-plating provision
- 2022
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Ingår i: Journal of Intellectual Property Law & Practice. - : Oxford University Press (OUP). - 1747-1532 .- 1747-1540. ; 17:9, s. 741-747
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Tidskriftsartikel (refereegranskat)abstract
- • ‘Gold-plating’ is a term widely used with reference to the implementation of European Union(EU) directives. It refers to a situation in whicha national implementing provision extends thescope of an EU directive.• In operational terms, a gold-plating provision provides for additional burdens for businesses andindividuals alike; most importantly, it interfereswith the expected aims that a directive seeks toachieve.• Te Croatian implementation of the DSM Directive (Directive 2019/790) has several examples ofgold-plating provisions. In this article, only one isdiscussed: the transposing provision of Article 15.
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| 24. |
- Marusic, Branka, 1983-
(författare)
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Wine wars : They might start when you are outside the EU club, but they end once you are in the club
- 2020
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Ingår i: Journal of Intellectual Property Law & Practice. - : Oxford University Press (OUP). - 1747-1532 .- 1747-1540. ; 15:12, s. 949-950
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- General Court, Case T-626/17, Slovenia v Commission, ECLI:EU:T:2020:402The General Court dismissed Slovenia’s action for annulment of Commission Delegated Regulation (EU) 2017/1353 of 19 May 2017 amending Regulation (EC) No 607/2009 as regards the wine grape varieties and their synonyms that may appear on wine labels (2017 OJ L190, 5), which allowed Croatia to use the name ‘teran’, a Slovenian protected designation of origin for wine
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| 25. |
- Molander, Lena, 1983-, et al.
(författare)
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Lower systolic blood pressure is associated with greater mortality in people aged 85 and older
- 2008
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Ingår i: Journal of The American Geriatrics Society. - : Wiley. - 0002-8614 .- 1532-5415. ; 56:10, s. 1853-1859
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To investigate the association between blood pressure and mortality in very old people. DESIGN: Population-based cohort study. SETTING: County of Västerbotten, Sweden. PARTICIPANTS: Half of all subjects aged 85 and all of those aged 90 and 95 and older (N=348) in one urban and five rural municipalities in the north of Sweden. MEASUREMENTS: Among others, supine blood pressure, Mini-Mental State Examination, Barthel Index of activities of daily living, Mini Nutritional Assessment, and body mass index. Information on diagnoses, medications, and 4-year mortality was collected. Associations between blood pressure and mortality were investigated using Cox regression analyses, controlling for a number of diagnoses and health factors. RESULTS: Baseline systolic blood pressure (SBP), diastolic blood pressure, and pulse pressure were all inversely associated with mortality within 4 years according to univariate analysis. SBP was the strongest predictor. In Cox regression analyses, low SBP (≤120 mmHg) correlated with greater 4-year all-cause mortality alone and when controlling for health status. This connection persisted after exclusion of deaths within the first year. There was a tendency toward a U-shaped mortality curve for the adjusted model, with SBP of 164.2 mmHg (95% confidence interval=154.1–183.8 mmHg) being associated with the lowest mortality. CONCLUSION: Lower SBP seems to be associated with greater mortality in people aged 85 and older, irrespective of health status. There are indications of a U-shaped correlation between SBP and mortality, and the optimal SBP for this age group could be above 140 mmHg.
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| 26. |
- Månsson, Kristofer, 1983-
(författare)
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A Wavelet-Based Approach of Testing for Granger Causality in the Presence of GARCH Effects
- 2012
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Ingår i: Communications in Statistics - Theory and Methods. - : Taylor & Francis. - 0361-0926 .- 1532-415X. ; 41:4, s. 717-728
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Tidskriftsartikel (refereegranskat)abstract
- The size and power of the most commonly used tests and a new wavelet-based approach of testing for Granger causality is evaluated in this paper by means of a Monte Carlo study in which the error term follows a generalized autoregressive conditional heteroscedasticity consistent (GARCH) process. In the simulation study it is shown that the commonly used causality tests tends to over-reject the true null hypothesis in the presence of GARCH errors and that the new wavelet-based approach improves the size properties of the Granger causality test for all of the different situations evaluated.
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| 27. |
- Månsson, Kristofer, 1983-, et al.
(författare)
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Granger Causality Test in the Presence of Spillover Effects
- 2009
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Ingår i: Communications in statistics. Simulation and computation. - : Informa UK Limited. - 0361-0918 .- 1532-4141. ; 38:10, s. 2039-2059
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we investigate the effect of spillover (i.e., causality in variance) on the reliability of Granger causality test based on ordinary least square estimates. We studied eight different versions of the test both, with and without Whites heteroskedasticity consistent covariance matrix (HCCME). The properties of the tests are investigated by means of a Monte Carlo experiment where 21 different data generating processes (DGP) are used and a number of factors that might affect the test are varied. The result shows that the best choice to test for Granger causality under the presence of spillover is the Lagrange Multiplier test with HCCME.
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| 28. |
- Månsson, Kristofer, 1983-, et al.
(författare)
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Performance of Some Ridge Regression Estimators for the Multinomial Logit Model
- 2018
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Ingår i: Communications in Statistics - Theory and Methods. - : Taylor & Francis. - 0361-0926 .- 1532-415X. ; 47:12, s. 2795-2804
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Tidskriftsartikel (refereegranskat)abstract
- This article considers several estimators for estimating the ridge parameter k for multinomial logit model based on the work of Khalaf and Shukur (2005), Alkhamisi et al. (2006), and Muniz et al. (2012). The mean square error (MSE) is considered as the performance criterion. A simulation study has been conducted to compare the performance of the estimators. Based on the simulation study we found that increasing the correlation between the independent variables and the number of regressors has negative effect on the MSE. However, when the sample size increases the MSE decreases even when the correlation between the independent variables is large. Based on the minimum MSE criterion some useful estimators for estimating the ridge parameter k are recommended for the practitioners
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| 29. |
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| 30. |
- Onerup, Aron, 1983, et al.
(författare)
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Effects of a home-based exercise program on the insulin-like growth factor axis in patients operated for colorectal cancer in Sweden: Results from the randomised controlled trial PHYSSURG-C
- 2020
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Ingår i: Growth Hormone and IGF Research. - : Elsevier BV. - 1096-6374 .- 1532-2238. ; 51, s. 27-33
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: We report results from a subgroup within the ongoing PHYSSURG-C trial with the aim to examine effects of exercise on IGF-1 and IGFBP-3 in patients undergoing colorectal cancer surgery. Design: Randomised controlled trial. Setting: A Swedish university hospital. Participants: Between 2015 and 2016, 217 patients were enrolled (I = 106, C = 111), with 122 patients that had given blood samples at baseline and at least at one follow-up (I = 51, C = 71). Patients 20 year or older with colorectal cancer were eligible. Exclusion criteria were emergency surgery, local surgery, language problems or inability to perform intervention. Interventions: Patients were computer-randomised to either a daily home-based aerobic exercise intervention (I), or to usual care (C). The intervention lasted two weeks before surgery and four weeks after discharge from hospital and consisted of medium-intensity aerobic exercise and inspiratory muscle training. Circulating concentrations of IGF-1 and IGFBP-3 were determined by blinded personnel at baseline, time of surgery and 4–6 weeks postoperatively. Primary and secondary outcome measures: The outcome of this subpopulation report was change in IGF-1/IGFBP-3 ratio, IGF-1 and IGFBP-3 concentrations from baseline to surgery, and 4–6 weeks postoperatively. Results: The IGF-1/IGFBP-3 ratio increased from baseline to surgery by 11% in I and 8% in C with no difference between groups (I vs. C: 1.04, 95%CI: 0.97–1.11; p = 1.000). Postoperative change was 5% in I and 3% in C with no difference between groups (I vs. C:1.03, 95%CI: 0.96–1.10; p = 1.000). Results concerning IGF-1 and IGFBP-3 also showed statistically significant dynamics over time with no difference between groups. No adverse events were reported. Conclusions: The home-based exercise program in our trial did not have any effect on IGF-1, or IGFBP-3. Trial registration: The study was registered at ClinicalTrials.gov with identifier NCT02299596. This work was funded externally.
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| 31. |
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| 32. |
- Rezk, Kamal, 1983-, et al.
(författare)
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Simulation of water removal in paper based on a 2D Level-Set model coupled with volume forces representing fluid resistance in 3D fiber distribution
- 2015
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Ingår i: Drying Technology. - : Taylor & Francis. - 0737-3937 .- 1532-2300. ; 33:5, s. 605-615
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Tidskriftsartikel (refereegranskat)abstract
- A numerical model of a vacuum dewatering process was established with a Level-Set method to simulate two-phase flow in a 2-dimensional paper sheet model with constructed volume forces representing flow resistance in a 3-dimensional environment. Nine cases of various volume force representations were compared to numerical and experimental data. Based on the dry content and dwell time relation, the case with the influence of the paper/wire interface showed the most pleasing result compared to experimental data. Compared to the other numerical cases, considering the blockage of the pore space at the top layer of the forming fabric plays an essential role in determining the flow resistance during the vacuum process. Also, the dynamics of the dewatering rate is captured well with the influence of the blockage of fibers on the top layer of the forming fabric. The peak of the dewatering rate could be investigated further with a higher frequency of sample points on new experimental data.The computational time for the two-phase flow models in this study is extensively reduced due to the removal of the internal structure. This distinction enables time efficient simulations of vacuum dewatering process in which several dewatering parameters such as level of vacuum, influence of moving vacuum pulse and higher basis weights could be investigated.
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| 33. |
- Rådman, Lisa, 1983-, et al.
(författare)
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Modified Rivermead Mobility Index : a reliable measure in people within 14 days post-stroke
- 2015
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Ingår i: Physiotherapy Theory and Practice. - : Taylor & Francis. - 0959-3985 .- 1532-5040. ; 31:2, s. 126-129
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The reliability of the Modified Rivermead Mobility Index (MRMI) has not previously been investigated in the very early post-stroke phase. The aim of the study was to evaluate inter-rater and intra-rater reliability and internal consistency in patients, 1-14 d post-stroke.Method: A cohort study with repeated measures within 24 h, on 37 patients, 1-14 d post-stroke was conducted. Inter-rater (two raters) and intra-rater (one rater) reliability was analyzed using weighted kappa (kappa) statistics and internal consistency with Cronbach's alpha and intra-class correlation (ICC), 3.k.Results: Inter-rater and intra-rater reliability was excellent (ICC coefficient 0.97 and 0.99) for MRMI summary score. Intra-rater exact agreement for separate items was between 77% and 97%; kappa between 0.81 and 0.96. Inter-rater exact agreement for separate items was between 68% and 92%; kappa 0.59-0.87. The internal consistency was high (alpha 0.96; ICC 3.k 0.99). Conclusion: The MRMI is a reliable measure of physical mobility in the early post-stroke phase.
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| 34. |
- Schyllert, Christian, 1983-, et al.
(författare)
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Childhood onset asthma is associated with lower educational level in young adults – A prospective cohort study
- 2021
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Ingår i: Respiratory Medicine. - : Elsevier. - 0954-6111 .- 1532-3064. ; 186
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundAsthma is associated with low socioeconomic status among both children and adults, and adolescents with asthma report more school absenteeism than those without. However, it is unclear whether asthma in childhood and adolescence affects socioeconomic status in adulthood.MethodsWithin the Obstructive Lung disease In Northern Sweden Studies, all children in grade 1 and 2 in three municipalities were invited to a questionnaire survey, 97% participated (n=3430). They were followed annually until age 19, and thereafter at age 28 years. In this study, participants at ages 8y, 12y, 19y and 28y (n=2017) were included. Asthma was categorized into childhood onset (up to age 12y) and adolescent onset (from 12 to 19y). Data for assessment of socioeconomic status was collected at 28y and included educational level, occupation, and occupational exposure to gas, dust and/or fumes (GDF).ResultsChildhood onset asthma was associated with having compulsory school as the highest educational level at age 28y, also after adjustment for sex, smoking and BMI at age 19y and socioeconomic factors in childhood (OR 4.84 95%CI 2.01-11.65), and the pattern was the same among men and women. However, we found no significant associations between asthma in childhood or adolescence and socioeconomic groups, occupational groups or occupational exposure to GDF at age 28y.ConclusionsEven though asthma in high-income countries, such as Sweden, is well recognised and treated, this study highlight that childhood onset asthma may have a negative long-term effect with regard to educational level in young adulthood.
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| 35. |
- Schyllert, Christian, 1983-, et al.
(författare)
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Socioeconomic inequalities in asthma and respiratory symptoms in a high-income country: changes from 1996 to 2016
- 2023
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Ingår i: Journal of Asthma. - : Informa UK Limited. - 0277-0903 .- 1532-4303. ; 60:1, s. 185-194
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Low socioeconomic status based both on educational level and income has been associated with asthma and respiratory symptoms, but changes over time in these associations have rarely been studied. The aim was to study the associations between educational or income inequality and asthma and respiratory symptoms among women and men over a 20-year period in northern Sweden. Methods: The study was performed within the Obstructive Lung disease in Northern Sweden (OLIN) research program. Mailed questionnaire surveys were administered to a random sample of adults (20-69 years of age) living in Sweden, in 1996, 2006 and 2016. Data on educational level and income were collected from the national integrated database for labor market research. Results: The educational inequality associated with asthma and asthmatic wheeze tended to decrease from 1996 to 2016, while it increased for productive cough, the latter among men not among women. The income inequality decreased for productive cough, especially for women, while no clear overall trends were found for asthmatic wheeze and asthma, apart from a decrease in income inequality regarding asthma among men. Conclusion: The patterns for socioeconomic inequality differed for asthma and wheeze compared to productive cough, and the results emphasize that education and income do not mirror the same aspects of socioeconomic inequality in a high-income country. Our findings are important for decision makers, not the least on a political level, as reduced inequality, e.g. through education, could lead to reduced morbidity.
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| 36. |
- Sinclair, Samantha, 1983-, et al.
(författare)
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Do Social Norms Influence Young People’s Willingness to Take the COVID-19 Vaccine?
- 2023
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Ingår i: Health Communication. - : Taylor & Francis Group. - 1041-0236 .- 1532-7027. ; 38:1, s. 152-159
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Tidskriftsartikel (refereegranskat)abstract
- Although young adults are not at great risk of becoming severely ill with COVID-19, their willingness to get vaccinated affects the whole community. Vaccine hesitancy has increased during recent years, and more research is needed on its situational determinants. This paper reports a preregistered experiment (N = 654) that examined whether communicating descriptive social norms – information about what most people do – is an effective way of influencing young people’s intentions and reducing their hesitancy to take the COVID-19 vaccine. We found weak support for our main hypothesis that conveying strong (compared to weak) norms leads to reduced hesitancy and stronger intentions. Furthermore, norms did not produce significantly different effects compared to standard vaccine information from the authorities. Moreover, no support was found for the hypothesis that young people are more strongly influenced by norms when the norm reference group consists of other young individuals rather than people in general. These findings suggest that the practical usefulness of signaling descriptive norms is rather limited, and may not be more effective than standard appeals in the quest of encouraging young adults to trust and accept a new vaccine.
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| 37. |
- Sund, Maria, 1983-, et al.
(författare)
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Aromatase inhibitors use and risk for cardiovascular disease in breast cancer patients : A population-based cohort study
- 2021
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Ingår i: Breast. - : Elsevier. - 0960-9776 .- 1532-3080. ; 59, s. 157-164
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Prior studies regarding use of Aromatase inhibitors (AIs) and risk for cardiovascular disease (CVD) have shown conflicting results. This retrospective cohort study aimed to investigate whether AIs use affects risk for CVD events in postmenopausal breast cancer survivors.METHODS: Using a retrospective cohort study design, four CVD outcomes; heart failure or cardiomyopathy, arrhythmia, acute ischemic heart disease and ischemic stroke or Transient Ischemic Attack were compared with uni- and multivariate Cox regression analyses according to exposure to endocrine therapy (use of AI, tamoxifen or AI/tamoxifen sequentially) or no endocrine therapy.RESULTS: In total 15815 postmenopausal women, surgically treated to early breast cancer during 2006-2012, were included. No significantly increased risk for CVD events was observed in patients with AI use in the whole cohort. However, two subgroup analyses showed increased risk for CVD events in the AI/tamoxifen sequential group; heart failure in patients older than 75 years (Hazard Ratio (HR) 2.44; 95% Confidence Interval (CI): 1.32-4.54) and arrhythmia in patients without prior CVD (HR 1.45; 95% CI: 1.01-2.10). An increased risk for arrhythmia and acute ischemic heart disease in patients with at least four years of AI treatment compared with no or short-time exposure was observed (HR 2.12; 95% CI: 1.40-3.25 for arrhythmia; HR 2.03; 95% CI: 1.15-3.58 for ischemic heart disease).CONCLUSION: Our results indicate an increased risk for ischemic heart disease and arrhythmia in patients treated for more than four years with AIs. This should be considered in the risk-benefit assessment concerning endocrine therapy.
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| 38. |
- Östh, Jonas, 1983, et al.
(författare)
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Driver Kinematic and Muscle Responses in Braking Events with Standard and Reversible Pre-tensioned Restraints: Validation Data for Human Models
- 2013
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Ingår i: Stapp car crash journal. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 1532-8546. ; 57, s. 1-41
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Tidskriftsartikel (refereegranskat)abstract
- The objectives of this study are to generate validation data for human models intended for simulation of occupant kinematics in a pre-crash phase, and to evaluate the effect of an integrated safety system on driver kinematics and muscle responses. Eleven male and nine female volunteers, driving a passenger car on ordinary roads, performed maximum voluntary braking; they were also subjected to autonomous braking events with both standard and reversible pre-tensioned restraints. Kinematic data was acquired through film analysis, and surface electromyography (EMG) was recorded bilaterally for muscles in the neck, the upper extremities, and lumbar region. Maximum voluntary contractions (MVCs) were carried out in a driving posture for normalization of the EMG. Seat belt positions, interaction forces, and seat indentions were measured.During normal driving, all muscle activity was below 5% of MVC for females and 9% for males. The range of activity during steady state braking for males and females was 13–44% in the cervical and lumbar extensors, while antagonistic muscles showed a co-contraction of 2.3–19%. Seat belt pre-tension affects both the kinematic and muscle responses of drivers. In autonomous braking with standard restraints, muscle activation occurred in response to the inertial load. With pre-tensioned seat belts, EMG onset occurred earlier; between 71 ms and 176 ms after belt pre-tension. The EMG onset times decreased with repeated trials and were shorter for females than for males. With the results from this study, further improvement and validation of human models that incorporate active musculature will be made possible.
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| 39. |
- Löfström Engdahl, Elin, 1983, et al.
(författare)
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Comparison of the Extraction as a Function of Time in two GANEX solvents -Influence of Metal Loading, Interfacial Tension and Density
- 2013
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Ingår i: Solvent Extraction and Ion Exchange. - : Informa UK Limited. - 0736-6299 .- 1532-2262. ; 31:6, s. 604-616
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Tidskriftsartikel (refereegranskat)abstract
- Two Group ActiNide EXtraction solvents for the extraction of actinides from used nuclear fuel for transmutation purpose have been compared. The solvent studied more precisely comprises cyclohexanone, tributylphosphate and a molecule from the bis-triazine bi-pyridine family, whilethe alternative utilizes di-ethyl-hexyl butyramide instead of tributylphospate. The focus of the comparison has been on the kinetics of the extraction of americium and europium, and the influence of an increased metal content on their separation factor. Both systems showed to maintain the equilibrium separation factor up to an europium concentration of 1 mM and their SFAm/Eu is decreased with a prolonged phase contact.
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| 40. |
- Bunderen, Christa C. van, et al.
(författare)
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Meta-analysis of mortality in adults with growth hormone deficiency: Does growth hormone replacement therapy really improve mortality rates?
- 2023
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Ingår i: BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. - 1521-690X .- 1532-1908. ; 37:6
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Tidskriftsartikel (refereegranskat)abstract
- Growth hormone (GH) deficiency (GHD) is one of the most prevalent deficiencies in patients with hypopituitarism and several cohort studies have demonstrated an increased mortality risk in hypopituitary pa-tients with a presumed GHD. The cause of the excess mortality is most likely multifactorial, including the etiology of the hypopituitarism, non-physiological replacement therapies (mostly glucocorticoid), tumor treatment and its side effects as well as untreated GHD. Several years later, other cohort studies that investigated life expectancy in patients with hypopituitarism on GH replacement therapy (GHRT) that showed a normalized mortality. By comparison of the distribution of char-acteristics of interest between cohorts, we discuss the existing literature to answer the following question: does growth hormone replacement really improve mortality rates in adult patients with hypopituitarism and GHD? We also conducted a meta-analysis of these studies. Since the literature suffers from selection and time bias (improvement of tumor management and other pituitary hormone replacement therapies), there is no high-quality evidence that replacement therapy for GHD really improves mortality. However, the available data does suggest that GHRT plays a significant part in the normalization of the mortality in patients with hypopituitarism.
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| 41. |
- Damoiseaux, David, et al.
(författare)
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Presence of Five Chemotherapeutic Drugs in Breast Milk as a Guide for the Safe Use of Chemotherapy During Breastfeeding : Results From a Case Series.
- 2022
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Ingår i: Clinical Pharmacology and Therapeutics. - : John Wiley & Sons. - 0009-9236 .- 1532-6535. ; 112:2, s. 404-410
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Tidskriftsartikel (refereegranskat)abstract
- Little is known about infant's safety of chemotherapy during breastfeeding where evidence is limited to a few case reports. This lack of knowledge has led to a general tendency to advise against breastfeeding during cytotoxic therapy despite the overwhelming benefits that breastfeeding offers to both the mothers and their children. In this case series, the presence of five chemotherapies in breast milk was determined. The aim was to obtain insight into the presence of these drugs in breast milk to inform and help clinicians in making informed decisions for women who want to breastfeed. Three patients collected 24-hour samples of breast milk every day for 1, 2, or 3 weeks after chemotherapy, 210 in total. After determination of drug concentrations, the infant daily dose, relative daily infant dose (RID%) and cumulative RID were calculated. Cumulative RIDs in patients varied from 10% to values lower than 1%. Rich data allowed us to design a table which gives predictions on the amount of days that breast milk has to be discarded to reach cumulative RIDs below 5, 1, and 0.1% for each compound. For cyclophosphamide, paclitaxel, and carboplatin, cumulative RIDs below 1 or 0.1% are reached if breast milk is discarded for 1-3 days after administration. This might suggest that breastfeeding in between cycles is an option. However, other pharmacological parameters should also be taken into consideration. For doxorubicin, also the levels of the active metabolite doxorubicinol need quantification. Similarly, breastfeeding during treatment with cisplatin might give substantial exposure and we advise caution.
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| 42. |
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| 43. |
- Gardela, Jaume, et al.
(författare)
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The mRNA expression of the three major described cold-inducible proteins, including CIRBP, differs in the bovine endometrium and ampulla during the estrous cycle
- 2022
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Ingår i: Research in Veterinary Science. - : Elsevier Science Ltd. - 0034-5288 .- 1532-2661. ; 152, s. 181-189
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Tidskriftsartikel (refereegranskat)abstract
- The cold-inducible proteins (CIPs) are essential for post-transcriptional gene regulation playing diverse tissue-specific roles in maintaining normal cellular function and morphogenesis. The potential implications of CIPs in reproductive events raise questions about their role in the physiology of the bovine reproductive tract. However, the expression changes of CIPs during the bovine estrous cycle have not been studied so far. Here, we hypothesized that the bovine estrous cycle could affect the mRNA expression of the CIPs and other candidate transcripts in the reproductive tract. This study aimed to examine estrous cycle-dependent mRNA expression patterns in the bovine endometrium and ampulla of three of the major described CIPs (CIRBP, RBM3, SRSF5), a set of inflammatory cytokines (IL-10, IL-18, IL-1 beta), and other candidate genes (IL-10RA, IL-10RB, BCL2, NLRP3, STAT1, STAT3, STAT5A, STAT6). Endometrial and ampullar tissues were assessed by RT-qPCR. Additionally, the mRNA expression levels were correlated among them and with follicular progesterone and estradiol concentrations. The transcript levels of CIPs increased in the endometrium during stage III (Days 11-17) compared to stage I (Days 1-4) and IV (Days 18-20). In the ampulla, the mRNA expression of CIRBP increased during the late luteal phase (stage III), but no differences in the expression of other CIPs were observed. This study expands the current knowledge regarding mRNA expression in the endometrium and oviductal ampulla of cycling heifers, focusing mainly on the CIPs. A better understanding of the mechanisms within the uterus and oviduct during the estrous cycle is crucial to improving the fertility rate.
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| 44. |
- Hallén, Tobias, et al.
(författare)
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Circulating brain injury biomarkers increase after endoscopic surgery for pituitary tumors.
- 2021
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Ingår i: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. - : Elsevier BV. - 1532-2653. ; 89, s. 113-121
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Tidskriftsartikel (refereegranskat)abstract
- Pituitary tumors and subsequent treatment with endoscopic transsphenoidal surgery (ETSS) may cause injury to suprasellar structures, causing long-term fatigue and neurocognitive impairment. A method to quantify brain injury after ETSS is not available. In this prospective, exploratory study of patients undergoing ETSS for pituitary tumors, a novel approach to detect possible neuronal damage is presented. Plasma concentrations of brain injury biomarkers (glial fibrillary acidic protein [GFAP], tau, and neurofilament light [NFL]) were measured the day before surgery, immediately after surgery, at day 1 and 5, and at 6 and 12months after surgery, using enzyme-linked immunosorbent assays. The association between the increase of biomarkers with preoperative tumor extension and postoperative patient-perceived fatigue was evaluated. Suprasellar tumor extension was assessed from MRI scans, and self-perceived fatigue was assessed using the Multidimensional Fatigue Inventory before and 6months after surgery. Thirty-five patients were included in the analysis. Compared to baseline, GFAP showed a maximal increase at day 1 after surgery (p=0.0005), tau peaked postoperatively on the day of surgery (p=0.019), and NFL reached its maximum at day 5 after surgery (p<0.0001). The increase in GFAP correlated with preoperative chiasmal compression (p=0.020). The increase in tau was correlated with preoperative chiasmal (p=0.011) and hypothalamus compression (p=0.016), and fatigue score 6months after surgery (p=0.016). In conclusion, the concentrations of brain injury biomarkers in blood increased after ETSS for pituitary tumors. The results indicate that postoperative plasma GFAP and tau might reflect astroglial and neuronal damage after ETSS.
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| 45. |
- Heckemann, Birgit, 1969, et al.
(författare)
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Finding the Person in Electronic Health Records. A Mixed-methods Analysis of Person-centered Content and Language
- 2022
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Ingår i: Health Communication. - : Informa UK Limited. - 1041-0236 .- 1532-7027. ; 37:4, s. 418-424
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Tidskriftsartikel (refereegranskat)abstract
- The co-creation and sharing of documentation of person-centered care is important, but challenging in clinical practice. Online access to health records is considered essential to increase patient participation and empowerment in person-centered care provision. The aims of this study were (1) to identify the extent of person-centered content in medical inpatient records and discharge letters; (2) to describe the characteristics of the language and rhetoric used in discharge letters. This was a concurrent, mixed-methods study involving a deductive, quantitative analysis of person-centered content in 69 Patient Accessible Electronic Health Records from patients with pituitary tumors, and an iterative, qualitative language analysis of a nested sample of 57 discharge letters. Both the content and language of inpatient records were mostly patient-centered. Records were concerned with the documentation of symptoms and medical and care interventions. There was little person-centered documentation of patients’ preferences, wishes and needs, and shared decision-making. In the discharge letters, written for the patients, some physicians had attempted to write in a person-centered way, using plain language and a narrative. However, most wrote in a style that was reflective of their discourse community, using abbreviations and medical terms. Established norms for documentation in healthcare are a barrier to person-centered documentation. Patients’ needs and preferences about documentation should be explored to increase understanding of how person-centered documentation can be achieved in clinical practice.
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| 46. |
- Jalasto, Juuso, et al.
(författare)
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Occupation, socioeconomic status and chronic obstructive respiratory diseases – the EpiLung Study in Finland, Estonia and Sweden
- 2022
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Ingår i: Respiratory Medicine. - : Elsevier. - 0954-6111 .- 1532-3064. ; 191
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To study occupational groups and occupational exposure in association with chronic obstructive respiratory diseases.Methods: In early 2000s, structured interviews on chronic respiratory diseases and measurements of lung function as well as fractional expiratory nitric oxide (FENO) were performed in adult random population samples of Finland, Sweden and Estonia. Occupations were categorized according to three classification systems. Occupational exposure to vapours, gases, dusts and fumes (VGDF) was assessed by a Job-Exposure Matrix (JEM). The data from the countries were combined.Results: COPD, smoking and occupational exposure were most common in Estonia, while asthma and occupations requiring higher educational levels in Sweden and Finland. In an adjusted regression model, non-manual workers had a three-fold risk for physician-diagnosed asthma (OR 3.18, 95%CI 1.07-9.47) compared to professionals and executives, and the risk was two-fold for healthcare & social workers (OR 2.28, 95%CI 1.14-4.59) compared to administration and sales. An increased risk for physician-diagnosed COPD was seen in manual workers, regardless of classification system, but in contrast to asthma, the risk was mostly explained by smoking and less by occupational exposure to VGDF. For FENO, no associations with occupation were observed.Conclusions: In this multicenter study from Finland, Sweden and Estonia, COPD was consistently associated with manual occupations with high smoking prevalence, highlighting the need to control for tobacco smoking in studies on occupational associations. In contrast, asthma tended to associate with non-manual occupations requiring higher educational levels. The occupational associations with asthma were not driven by eosinophilic inflammation presented by increased FENO.
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| 47. |
- Kennergren, Charles, 1948, et al.
(författare)
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A single-centre experience of over one thousand lead extractions.
- 2009
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Ingår i: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. - : Oxford University Press (OUP). - 1532-2092. ; 11:5, s. 612-7
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: The aim of the study was to present a single-centre experience of pacemaker and implantable cardioverter defibrillator (ICD) lead extraction using different methods, mainly laser-assisted extraction. METHODS AND RESULTS: Data from 1032 leads and 647 procedures were gathered. A step-by-step approach using different techniques while performing an ongoing risk-benefit analysis was used. The most common indications were local infection, systemic infection, non-functional lead, elective lead replacement, and J-wire fracture. Mean implantation time for all leads was 69 months and for laser-extracted leads 91 months. Laser technique was used to extract 60% of the leads, 29% were manually extracted, 6% extracted with mechanical tools, 4% were surgically removed, and 0.6% extracted by a femoral approach. Failure rate was 0.7%, and major complication rate was 0.9%. No extraction-related mortality occurred. Median time for laser extraction was 2 min. Long implantation time was not a risk factor for failure or for complication. CONCLUSION: Pacing and ICD leads can safely, successfully, and effectively be extracted. Leads can often be extracted by a superior transvenous approach; however, open-chest and femoral extractions are still required. Laser-assisted lead extraction proved to be a useful technique to extract leads that could not be removed by manual traction. The results indicate that the paradigm of abandoning redundant leads, instead of removing them, may have to be reconsidered.
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| 48. |
- Kinzer, M., et al.
(författare)
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Mesenchymal stromal cells from the human placenta promote neovascularization in a mouse model in vivo.
- 2014
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Ingår i: Placenta. - London : W. B. Saunders Co Ltd. - 0143-4004 .- 1532-3102. ; 35:7, s. 517-519
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Tidskriftsartikel (refereegranskat)abstract
- Cell transplantation is a promising strategy in regenerative medicine for revascularization of ischemic tissues. Based on our observation that placental mesenchymal stromal cells (PMSC) enhance endothelial cell viability in vitro via secretion of angiogenic factors, we asked whether PMSC support vascular growth in vivo. PMSC were isolated from amnion and placental endothelial cells (PLEC) from chorion and either separately or co-transplanted subcutaneously into immune-deficient mice. Co-transplantation resulted in a higher number of perfused human vessels (CD31+/vimentin+) containing mouse glycophorin A+ erythrocytes. Results indicate positive effects of PMSC on neovascularization in vivo, making them attractive candidates to create autologous PMSC/PLEC pairs for research and transplantation.
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| 49. |
- Ljungman, Lisa, 1981-, et al.
(författare)
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"There should be some kind of checklist for the soul" - A qualitative interview study of support needs after end of treatment for gynecologic cancer in young women
- 2021
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Ingår i: European Journal of Oncology Nursing. - : Elsevier. - 1462-3889 .- 1532-2122. ; 52
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Young women diagnosed with a gynecologic cancer face the risk of significant physical and mental health problems after end of treatment. Still, there is a lack of knowledge regarding specific support needs in this population, and supportive care services provided to young women with a gynecologic cancer have been reported to be insufficient. The aim of this study was therefore to identify support needs experienced by women diagnosed with a gynecologic cancer before the age of 40.Method: Qualitative semi-structured interviews were conducted with participants (n = 10). Interviews were analyzed using content analysis with an inductive approach.Results: Eight categories and two themes were identified. The themes described if these needs were related to how women wanted the support to be provided, or to what the support should contain, i.e., 'Form' and 'Content', respectively. The categories related to 'Form' included: Outreach support; Long-term specialized support; Support for the whole family; and Peer-support, whereas categories related to 'Content' included needs for: Support for psychological reactions; Support related to reproduction, sexuality, and family life; Information regarding late effects; and Support tailored to younger women.Conclusion: Women diagnosed with a gynecologic cancer during young adulthood report several specific support needs. The results provide important guidance to clinicians and health care providers by outlining these needs both in terms of form and content.
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| 50. |
- Lundberg, Peter, 1958-, et al.
(författare)
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Breast density is strongly associated with multiparametric magnetic resonance imaging biomarkers and pro-tumorigenic proteins in situ
- 2022
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Ingår i: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 127, s. 2025-2033
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Tidskriftsartikel (refereegranskat)abstract
- Background High mammographic density is an independent risk factor for breast cancer by poorly understood molecular mechanisms. Women with dense breasts often undergo conventional magnetic resonance imaging (MRI) despite its limited specificity, which may be increased by diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) and contrast. How these modalities are affected by breast density per se and their association with the local microenvironment are undetermined. Methods Healthy postmenopausal women attending mammography screen with extremely dense or entirely fatty breasts underwent multiparametric MRI for analyses of lean tissue fraction (LTF), ADC and perfusion dynamics. Microdialysis was used for extracellular proteomics in situ. Results Significantly increased LTF and ADC and delayed perfusion were detected in dense breasts. In total, 270 proteins were quantified, whereof 124 related to inflammation, angiogenesis, and cellular growth were significantly upregulated in dense breasts. Most of these correlated significantly with LTF, ADC and the perfusion data. Conclusions ADC and perfusion characteristics depend on breast density, which should be considered during the implementation of thresholds for malignant lesions. Dense and nondense breasts are two essentially different biological entities, with a pro-tumorigenic microenvironment in dense breasts. Our data reveal several novel pathways that may be explored for breast cancer prevention strategies.
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