| 1. |
- Albiin, N
(författare)
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MRI of Focal Liver Lesions
- 2012
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Ingår i: Current medical imaging reviews. - : Bentham Science Publishers Ltd.. - 1573-4056. ; 8:2, s. 107-116
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Bajc, Marika
(författare)
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Ventilation/Perfusion SPECT - A New Challenge for Detection of Pulmonary Embolism. Can Multi Detector Computed Tomography Replace Lung Scintigraphy?
- 2009
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Ingår i: Current Medical Imaging Reviews. - : Bentham Science Publishers Ltd.. - 1875-6603 .- 1573-4056. ; 5:3, s. 174-179
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Forskningsöversikt (refereegranskat)abstract
- ventilation/perfusion scintigraphy (V/P-SCAN) was the procedure of choice for studying patients with suspected pulmonary embolism (PE) until the prospective evaluation of V/P imaging in the study known as PIOPED I revealed high number of non diagnostic findings. This has challenged development of computed tomography (CT) during 1990s. Since beginning of 2000, multidetector CT (MDCT) is widely applied and has become the most commonly used technique in patients with suspected PE. The current MDCT have very advanced technology and have improved ability to detect small emboli. Unfortunately, results of the most advanced MDCT are still compared with V/P-SCAN results performed in PIOPED I 20 years ago. However V/P-SCAN has further developed. Tomographic technique V/P-SPECT is taking over V/P-PLANAR. Probabilistic criteria are replaced by holistic criteria for interpretation, taking lessons learned from PIOPED I. Discussion is focused on diagnostic value for MDCT and V/P-SPECT. MDCT and V/P-SPECT are both indispensible imaging techniques to study patients with suspected PE. However, when available, V/P-SPECT should be the preferred method for diagnosis of PE, primarily due to the lower radiation exposure and applicability to all patients. Therefore it is our duty to make V/P-SPECT generally more available, to use holistic interpretation knowledge and to communicate daily with the clinicians, so that the best technique is used in all patients. In conclusion MDCT cannot replace V/P-SPECT. MDCT and V/P-SPECT are complementary rather the competitive!
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| 3. |
- Chakera, Annette H., et al.
(författare)
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Sentinel node imaging
- 2006
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Ingår i: Current Medical Imaging Reviews. - : Bentham Science Publishers Ltd.. - 1875-6603 .- 1573-4056. ; 2:3, s. 341-346
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Forskningsöversikt (refereegranskat)abstract
- Breast cancer and melanoma metastasize predominantly via the lymphatic route. It has long been known that invasion into one or a few nodes draining the primary tumour, the sentinel nodes (SN), is the most important, early sign of dissemination. If no malignant cells are detected in the SN, dissemination is unlikely to be expected. For the last 10 years SN biopsy has become an important tool in staging cancers. Two kinds of tracers are used for SN detection: The blue dye, injected during operation, and radioactively labelled colloid, injected before operation. The lymphatic drainage can then be mapped by following the blue dye by visual inspection during the operation, and with gamma camera imaging before and probe detection during the operation. The variations in the tracers used, and the injection and imaging techniques are discussed. The pathologic examination has also undergone a rapid evolution with more detailed analysis including immunohistochemistry. The use of the SN technique has quickly spread worldwide for melanoma and breast cancer but is also being tested in several other cancers. Reports on the influence on morbidity and mortality reduction are becoming increasingly convincing. The near future of SN examination is finally briefly outlined.
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| 4. |
- Hernandez-Andrade, Edgar, et al.
(författare)
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Fractional moving blood volume measurement using power Doppler ultrasound as an estimation of fetal organ blood perfusion
- 2006
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Ingår i: Current Medical Imaging Reviews. - : Bentham Science Publishers Ltd.. - 1875-6603 .- 1573-4056. ; 2:3, s. 365-372
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Forskningsöversikt (refereegranskat)abstract
- Fractional moving blood volume (FMBV) estimated using power Doppler ultrasound (PDU) is a sensitive technique to detect slow blood movement. However, several factors as; depth, attenuation and blood characteristics can affect the PDU signals. The aim of this study was to standardized and validate the FMBV measurement compensating for the factors that can affect the final results, in order to accurate estimate blood movement in a specific region of interest (ROI) of fetal organs as an estimation of blood perfusion. FMBV measurement for the fetal lung blood perfusion was standardized in 29 healthy fetuses at 35-37 weeks of gestation. Clear definition of the ROI in both fetal lungs was proposed. FMBV values were in the range of 27-42% (mean 36.2%) and showed a coefficient of variation of 0.14. No significant differences between the FMBV values obtained from the left and the right lungs, or between cardiac systole and diastole were observed. A phantom experimental study showed good sensitivity for slow blood movement. FMBV was then compared with blood perfusion measurements evaluated with radioactive labeled microspheres (RMS) in the adrenal gland of 5 fetal lambs exposed to severe asphyxia. There was a high correlation between FMBV and RMS (r=0.90, range 0.43-0.99). The reproducibility and agreement analyses showed an intraclass correlation coefficient of 0.92 (95% confidence intervals [CI] 0.78-0.96), and a mean difference between observers of 0.06 (SD, 3.7). Conclusion. The estimation of the fractional moving blood volume measurement using power Doppler ultrasound can be reliable correlated with true fetal organ blood perfusion. FMBV is a reproducible method that can offer valuable information about adaptive fetal blood flow changes in the presence of pregnancy associated complications.
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| 5. |
- Park, Jennifer, et al.
(författare)
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A Comparison of Liver MRI and Contrast-Enhanced CT as Standard Workup Before Treatment for Rectal Cancer in Usual Care - A Retrospective Study
- 2022
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Ingår i: Current Medical Imaging. - : Bentham Science Publishers Ltd.. - 1573-4056. ; 18:2, s. 256-262
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Tidskriftsartikel (refereegranskat)abstract
- Background: The liver is the most common site for rectal cancer metastases. Recommended standard pre-treatment workups have involved Computed Tomography (CT) for abdominal metastases, however, few hospitals have replaced this with Magnetic Resonance Imaging (MRI). Introduction: The aim of this study was to compare MRI with CT as an index examination of the liver in the pre-treatment workup in usual care. The primary endpoint was the need for supplementary liver investigations. Methods: Consecutive patients from two hospitals during 2013-2015 were identified in the Regional Swedish Colorectal Cancer Register and included in this retrospective study. Hospital records and radiology reports were reviewed. Inconclusive reports were re-evaluated by two radiologists. Results: A total of 320 patients were included, and 293 were available for analysis. Some 175 and 118 patients had undergone CT and MRI respectively, as their index pre-treatment liver examination. Thirty-four (19.4%) in the CT group and 6 (5.1%) patients in the MRI group underwent supplementary liver investigation due to inconclusive index examination (RR 3.82, 95% CI: 1.66; 8.81, p=0.0017). Median time (q1; q3) from index examination to start of treatment was 50 (36; 68) days in the CT group and 34 (27; 45) days in the MRI group. Conclusion: This retrospective study of two modalities within usual care found that MRI of the liver as index radiological workup before treatment for rectal cancer was associated with fewer supplementary liver investigations and a shorter time to start of treatment. Based on these findings, a prospective trial should be undertaken before implementing MRI as a standard. © 2022 Bentham Science Publishers.
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| 6. |
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| 7. |
- Torkzad, Michael R., et al.
(författare)
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The Clinical Perspective on Value of 3D, Thin Slice T2-Weighted Images in 3T Pelvic MRI for Tumors
- 2012
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Ingår i: Current Medical Imaging Reviews. - : Bentham Science Publishers Ltd.. - 1573-4056. ; 8:2, s. 76-81(6)
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Tidskriftsartikel (refereegranskat)abstract
- Pelvic imaging is undergoing rapid changes due to increased use of 3-Tesla (3T) magnetic resonance imaging (3T MRI). One of the advantages of 3T could be the possibility for thin section 3-dimensional (3D) imaging which could improve accuracy and at the same time reduce the need for multi-planar imaging needed for conventional T2 imaging (TSE). In the following text we review the advantages of 3D thin section imaging for assessment of pelvic tumors.
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| 8. |
- Brundin, Lena, et al.
(författare)
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Orexin and psychiatric symptoms in suicide attempters.
- 2007
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Ingår i: Journal of Affective Disorders. - : Elsevier BV. - 1573-2517 .- 0165-0327. ; 100:1-3, s. 259-263
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The orexins (hypocretins) are recently discovered hypothalamic peptides that are involved in the regulation of sleep, appetite and state of arousal. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symptoms in suicidal patients. METHODS: A total of 101 patients were enrolled in the study shortly after a suicide attempt. All patients underwent a lumbar puncture after a wash-out period during which they did not receive any antipsychotic or antidepressive medication. Structured interviews were performed using the Comprehensive Psychopathological Rating Scale (CPRS). CSF-orexin-A was measured and correlated with ratings of psychiatric symptoms. RESULTS: There were significant and negative correlations between CSF-orexin and the symptoms lassitude (difficulty to initiate activities) and slowness of movement, as well as the ratings of global illness (p<0.005 for all three items, Spearman's rho). LIMITATIONS: Correlation analysis is an indirect method of investigation and does not demonstrate causal relationships. CONCLUSION: Low CSF-orexin levels are related to pronounced symptoms of inertia and reduced motor activity in suicidal patients. Interestingly, the lower the orexin levels, the higher were ratings of overall illness, as observed by a specialist in psychiatry. Our results suggest that reduced orexin levels are involved in the etiology of specific psychiatric symptoms.
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