| 1. |
- Hegazy, Mohamed-Elamir F., et al.
(författare)
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Cytotoxic Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum
- 2011
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Ingår i: Natural Product Communications. - 1934-578X .- 1555-9475. ; 6:12, s. 1809-1812
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Tidskriftsartikel (refereegranskat)abstract
- One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7 alpha,8 beta-dihydroxydecpoxysarcophine (2), 7 beta-acetoxy-8 alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7 beta-Acetoxy-8 alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC(50) values of 3.6, 2.3, and 6.7 mu g/mL, respectively.
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| 2. |
- Almanza, Giovanna R., et al.
(författare)
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Antioxidant and Antimutagenic Polyisoprenylated Benzophenones and Xanthones from Rheedia acuminata
- 2011
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Ingår i: Natural Product Communications. - 1934-578X. ; 6:9, s. 1269-1274
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Tidskriftsartikel (refereegranskat)abstract
- Dichloromethane extract of the stem bark of Rheedia acuminata yielded three benzophenones with antioxidant activity, the new one named acuminophenone A (1), guttiferone K (2) and isoxanthochymol (3), along with the known xanthones formoxanthone C (4) and macluraxanthone (5). The structures were established through interpretation of their spectroscopic data, the stereochemistry of compounds (1) and (2) were resolved by experimental and computational experiments and their antioxidant activities were measured using the DPPH, ABTS and TEAC assays. The antioxidant results showed that metabolites 1, 4 and 5 had a better antioxidant activity than the reference compound quercetin. In addition, we evaluate the mutagenicity and antimutagenicity of the CH2Cl2 extract as well as of the free radical scavenger compounds 1, 4 and 5 by the AMES Salmonella/microsomal test. No mutagenicity was found in the CH2Cl2 extract using Salmonella typhimurium strains TA98, TA100, TA102, TA1537 and TA1538, with or without S9 metabolic activation. The pure compounds neither showed mutagenicity in TA 102 strain and the most important result was the strong reduction of mutagenic effect induced by hydrogen peroxide in S. typhimurium TA 102, with or without S9, showed by the compounds 1 (more than 93%) and 4 (more than 88%) at 0.02 mu g/plate.
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| 3. |
- Appendino, Giovanni, et al.
(författare)
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A Polar Cannabinoid from Cannabis sativa var. Carma
- 2008
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Ingår i: Natural Product Communications. - 1934-578X. ; 3:12, s. 1977-1980
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Tidskriftsartikel (refereegranskat)abstract
- The aerial parts of Cannabis saliva var. Carma afforded a novel polar cannabinoid whose structure was established as rac-6',7'-dihydro,6',7'-dihydroxycannabigerol (carmagerol, 1) on the basis of spectroscopic data and semisynthesis from cannabigerol (2a). The dihydroxylation of the omega-double bond was detrimental to the anti-bacterial activity.
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| 4. |
- El-Seedi, Hesharn R.
(författare)
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Antimicrobial activity and chemical composition of essential oil of Eupatorium glutinosum (Lam.)
- 2006
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Ingår i: Natural Products Communications. - 1934-578X. ; 1:8, s. 655-659
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Tidskriftsartikel (refereegranskat)abstract
- The essential oil obtained by steam distillation from the leaves and twigs of Eupatorium glutinosum Lam. (Asteraceae) showed antimicrobial activities against a Gram-positive bacterium, three Gram-negative bacteria and three fungi. The results from this study support the vernacular medicinal uses of the plant in folkloric medicine. The chemical composition of the essential oil was analysed by GC and GC-MS, resulting in the identification of 24 constituents accounting for 92.6% of the total mass. The major active component, carvacrol, was isolated using MPLC and characterized by NMR and MS analysis. beta-Glucosidasetreatment of the aqueous plant residue yielded a volatile fraction that did not show antimicrobial activitiy, in which the major components were octen-3-ol and (Z)-hex-2-en-1-ol. The essential oil from the species is reported for the first time.
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| 5. |
- Limachi, Ivan, et al.
(författare)
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Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant
- 2019
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Ingår i: Natural Product Communications. - 1934-578X. ; 14:1, s. 55-58
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Tidskriftsartikel (refereegranskat)abstract
- A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.
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| 6. |
- Ngarnga, Dieudonne, et al.
(författare)
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Anti-trypanosomal alkaloids from Xymalos monospora
- 2006
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Ingår i: Natural Product Communications. - 1934-578X. ; 1:8, s. 619-622
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Tidskriftsartikel (refereegranskat)abstract
- From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.
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| 7. |
- Pagani, Alberto, et al.
(författare)
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An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin
- 2007
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Ingår i: Natural Product Communications. - 1934-578X. ; 2:6, s. 637-642
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Tidskriftsartikel (refereegranskat)abstract
- A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.
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| 8. |
- Sohretoglu, Didem, et al.
(författare)
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A New Acylated Neohesperidoside from Geranium purpureum
- 2011
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Ingår i: Natural Product Communications. - 1934-578X. ; 6:9, s. 1321-1322
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Tidskriftsartikel (refereegranskat)abstract
- A new acylated neohesperoside derivative, 1-octyl-4'-isovaleroyl-neohesperoside (1), was isolated from Geranium purpureum Vill. (Geraniaceae) together with the known compounds quercetin-3-rutinoside and gallic acid. The identification of the isolated compounds was carried out by spectroscopic analysis including 1D- and 2D- NMR (H-1, C-13, COSY, HSQC and HMBC) spectroscopy and ESI-TOF-MS.
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| 9. |
- Sohretoglu, Didem, et al.
(författare)
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Antioxidant Effects of Secondary Metabolites from Geranium psilostemon
- 2010
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Ingår i: Natural Product Communications. - 1934-578X. ; 5:6, s. 899-902
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Tidskriftsartikel (refereegranskat)abstract
- An investigation was made of the effects on endogenous antioxidant enzyme activities and H2O2-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H2O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR) and spectrometric (TOF-MS) data. All extracts and isolated compounds inhibited H2O2-induced lipid peroxidation and also enhanced the activity of superoxide dismutase (SOD) and catalase (CAT).
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| 10. |
- Tchinda, Alembert T., et al.
(författare)
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A new strychnos alkaloid from Strychnos scheffleri
- 2007
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Ingår i: Natural Product Communications. - 1934-578X. ; 2:2, s. 147-149
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Tidskriftsartikel (refereegranskat)abstract
- A phytochemical investigation of the stem bark of Strychnos scheffleri resulted in the isolation of a new strychnos alkaloid N-a-deacetylmalagashine (1) together with the known derivative malagashine (2). Elucidation of the structures was based mainly on ID and 2D NMR and MS studies and by comparison with related compounds.
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