| 1. |
- Abuhattum, Shada, et al.
(författare)
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Intracellular Mass Density Increase Is Accompanying but Not Sufficient for Stiffening and Growth Arrest of Yeast Cells
- 2018
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 6:NOV
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Tidskriftsartikel (refereegranskat)abstract
- Many organisms, including yeast cells, bacteria, nematodes, and tardigrades, endure harsh environmental conditions, such as nutrient scarcity, or lack of water and energy for a remarkably long time. The rescue programs that these organisms launch upon encountering these adverse conditions include reprogramming their metabolism in order to enter a quiescent or dormant state in a controlled fashion. Reprogramming coincides with changes in the macromolecular architecture and changes in the physical and mechanical properties of the cells. However, the cellular mechanisms underlying the physical-mechanical changes remain enigmatic. Here, we induce metabolic arrest of yeast cells by lowering their intracellular pH. We then determine the differences in the intracellular mass density and stiffness of active and metabolically arrested cells using optical diffraction tomography (ODT) and atomic force microscopy (AFM). We show that an increased intracellular mass density is associated with an increase in stiffness when the growth of yeast is arrested. However, increasing the intracellular mass density alone is not sufficient for maintenance of the growth-arrested state in yeast cells. Our data suggest that the cytoplasm of metabolically arrested yeast displays characteristics of a solid. Our findings constitute a bridge between the mechanical behavior of the cytoplasm and the physical and chemical mechanisms of metabolically arrested cells with the ultimate aim of understanding dormant organisms.
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| 2. |
- Afzali, Maryam, et al.
(författare)
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Quantification of Tissue Microstructure Using Tensor-Valued Diffusion Encoding: Brain and Body
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 10
-
Forskningsöversikt (refereegranskat)abstract
- Diffusion-weighted magnetic resonance imaging (DW-MRI) is a non-invasive technique to probe tissue microstructure. Conventional Stejskal–Tanner diffusion encoding (i.e., encoding along a single axis), is unable to disentangle different microstructural features within a voxel; If a voxel contains microcompartments that vary in more than one attribute (e.g., size, shape, orientation), it can be difficult to quantify one of those attributes in isolation using Stejskal–Tanner diffusion encoding. Multidimensional diffusion encoding, in which the water diffusion is encoded along multiple directions in q-space (characterized by the so-called “b-tensor”) has been proposed previously to solve this problem. The shape of the b-tensor can be used as an additional encoding dimension and provides sensitivity to microscopic anisotropy. This has been applied in multiple organs, including brain, heart, breast, kidney and prostate. In this work, we discuss the advantages of using b-tensor encoding in different organs.
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| 3. |
- Ahmadi, Delaram, et al.
(författare)
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Nanoscale Structure and Dynamics of Model Membrane Lipid Raft Systems, Studied by Neutron Scattering Methods
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Quasi-elastic neutron scattering (QENS) and small angle neutron scattering (SANS), in combination with isotopic contrast variation, have been used to determine the structure and dynamics of three-component lipid membranes, in the form of vesicles, comprising an unsaturated [palmitoyl-oleoyl-phosphatidylcholine (POPC) or dioleoyl-phosphatidylcholine (DOPC)], a saturated phospholipid (dipalmitoyl-phosphatidylcholine (DPPC)), and cholesterol, as a function temperature and composition. SANS studies showed vesicle membranes composed of a 1:1:1 molar ratio of DPPC:DOPC:cholesterol and a 2:2:1 molar ratio of DPPC:POPC:cholesterol phase separated, forming lipid rafts of ∼18 and ∼7 nm diameter respectively, when decreasing temperature from 308 to 297 K. Phase separation was reversible upon increasing temperature. The larger rafts observed in systems containing DOPC are attributed to the greater mis-match in lipid alkyl chains between DOPC and DPPC, than for POPC and DPPC. QENS studies, over the temperature range 283–323K, showed that the resulting data were best modelled by two Lorentzian functions: a narrow component, describing the “in-plane” lipid diffusion, and a broader component, describing the lipid alkyl chain segmental relaxation. The overall “in-plane” diffusion was found to show a significant reduction upon increasing temperature due to the vesicle membranes transitioning from one containing rafts to one where the component lipids are homogeneously mixed. The use of different isotopic combinations allowed the measured overall reduction of in-plane diffusion to be understood in terms of an increase in diffusion of the saturated DPPC lipid and a corresponding decrease in diffusion of the unsaturated DOPC/POPC lipid. As the rafts are considered to be composed principally of saturated lipid and cholesterol, the breakdown of rafts decreases the exposure of the DPPC to cholesterol whilst increasing the exposure of cholesterol to unsaturated lipid. These results show the sensitivity of lipid diffusion to local cholesterol concentration, and the importance of considering the local, rather that the global composition of a membrane when understanding the diffusion processes of lipids within the membrane. The novel combination of SANS and QENS allows a non-intrusive approach to characterize the structure and dynamics occurring in phase-separated model membranes which are designed to mimic the lateral heterogeneity of lipids seen in cellular membranes–a heterogeneity that can have pathological consequences.
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| 4. |
- Becker, K. S., et al.
(författare)
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Ab initio symmetry-adapted emulator for studying emergent collectivity and clustering in nuclei
- 2023
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- We discuss emulators from the ab initio symmetry-adapted no-core shell-model framework for studying the formation of alpha clustering and collective properties without effective charges. We present a new type of an emulator, one that utilizes the eigenvector continuation technique but is based on the use of symplectic symmetry considerations. This is achieved by using physically relevant degrees of freedom, namely, the symmetry-adapted basis, which exploits the almost perfect symplectic symmetry in nuclei. Specifically, we study excitation energies, point-proton root-mean-square radii, along with electric quadrupole moments and transitions for 6Li and 12C. We show that the set of parameterizations of the chiral potential used to train the emulators has no significant effect on predictions of dominant nuclear features, such as shape and the associated symplectic symmetry, along with cluster formation, but slightly varies details that affect collective quadrupole moments, asymptotic normalization coefficients, and alpha partial widths up to a factor of two. This makes these types of emulators important for further constraining the nuclear force for high-precision nuclear structure and reaction observables.
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| 5. |
- Boito, Deneb, et al.
(författare)
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Multidimensional Diffusion MRI Methods With Confined Subdomains
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Diffusion Magnetic Resonance Imaging (dMRI) is an imaging technique with exquisite sensitivity to the microstructural properties of heterogeneous media. The conventionally adopted acquisition schemes involving single pulsed field gradients encode the random motion of water molecules into the NMR signal, however typically conflating the effects of different sources contributing to the water motion. Time-varying magnetic field gradients have recently been considered for disentangling such effects during the data encoding phase, opening to the possibility of adding specificity to the recovered information about the mediums microstructure. Such data is typically represented via a diffusion tensor distribution (DTD) model, thus assuming the existence of several non-exchanging compartments in each of which diffusion is unrestricted. In this work, we consider a model that takes confinement into account and possesses a diffusion time-dependence closer to that of restricted diffusion, to replace the free diffusion assumption in multidimensional diffusion MRI methods. We first demonstrate how the confinement tensor model captures the relevant signal modulations impressed by water diffusing in both free and closed spaces, for data simulated with a clinically feasible protocol involving time-varying magnetic field gradients. Then, we provide the basis for incorporating this model into two multidimensional dMRI methods, and attempt to recover a confinement tensor distribution (CTD) on a human brain dataset.
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| 6. |
- Brenner, Richard, et al.
(författare)
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Multi Gigabit Wireless Data Transfer in Detectors at Future Colliders
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 10
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Forskningsöversikt (refereegranskat)abstract
- The WADAPT (Wireless Allowing Data And Power Transmission) consortium has been formed to identify the specific needs of different projects that might benefit from wireless communication technologies with the objective of providing a common platform for research and development in order to optimize effectiveness and cost. Wireless technologies have developed extremely fast over the last decade and are now mature enough to be a promising alternative to cables and optical links, with a possibility of revolutionizing detector design. Although wireless readout has the qualities and properties to be used in many collider detectors, this article focuses on the transmission of large amount of data from vertex detectors at high rate, low power budget and in potential high radiation environment. For vertex detectors, the 60 GHz band has proven to be adequate and commercial products are already available, providing 6 Gbps data links. This technology allows efficient partitioning of detectors in topological regions of interest, with the possibility of adding intelligence on the detector to perform four-dimensional reconstruction of the tracks and vertices online, in order to attach the tracks to their vertex with great efficiency even in difficult experimental conditions, and conveniently substitutes a mass of materials (cables and connectors). Early transceiver module products have been successfully tested for signal confinement, crosstalk, electromagnetic immunity and resistance to radiation. In the long run, emerging 140 GHz bands could also be used for higher data rates (>100 Gbps) at future high energy and luminosity hadron colliders.
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| 7. |
- Brzozowska, Beata, et al.
(författare)
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Monte Carlo Modeling of DNA Lesions and Chromosomal Aberrations Induced by Mixed Beams of Alpha Particles and X-Rays
- 2020
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 8
-
Tidskriftsartikel (refereegranskat)abstract
- Prediction of health risks associated with exposure to mixed beams of high- and low-linear energy transfer ionizing radiation is based on the assumption that the biological effect caused by mixed radiation equals the sum of effects resulting from the action of individual beam components. Experimental studies have demonstrated that the cellular effects in cells exposed to mixed radiations are higher than that calculated based on the assumption of additivity. The present work contains a comparative analysis of published results on chromosomal aberrations in human peripheral blood lymphocytes exposed to mixed beams of alpha particles and X-rays with computer simulations using the PARTRAC program based on Monte Carlo methods. PARTRAC was used to calculate the levels of DNA single-strand breaks (SSB) and double-strand breaks (DSB—both complex and simple) and the level of chromosomal aberrations. SSB and DSB yields were found to be additive. A synergistic effect was obtained at the level of chromosomal aberrations, being in good agreement with the experimental results. This result demonstrates that the synergistic action of mixed beams results from processing of SSB and DSB and not from their initial frequencies. The level of synergy was dependent on the composition of the mixed beam, with highest level at 50:50 ratio of alpha particles and X-rays.
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| 8. |
- Cacciapaglia, Giacomo, et al.
(författare)
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Light scalars in composite Higgs models
- 2019
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Ingår i: Frontiers of Physics. - : Frontiers Media SA. - 2296-424X. ; 7:12
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Tidskriftsartikel (refereegranskat)abstract
- A composite Higgs boson is likely to be accompanied by additional light states generated by the same dynamics. This expectation is substantiated when realising the composite Higgs mechanism by an underlying gauge theory. We review the dynamics of such objects, which may well be the first sign of compositeness at colliders. We also update our previous analysis of the bounds from LHC searches to the latest results, and discuss the projected reach of the High-Luminosity run.
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| 9. |
- Cardoso, Fernando R., et al.
(författare)
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Detailed Account of Complexity for Implementation of Circuit-Based Quantum Algorithms
- 2021
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- In this review article, we are interested in the detailed analysis of complexity aspects of both time and space that arises from the implementation of a quantum algorithm on a quantum based hardware. In particular, some steps of the implementation, as the preparation of an arbitrary superposition state and readout of the final state, in most of the cases can surpass the complexity aspects of the algorithm itself. We present the complexity involved in the full implementation of circuit-based quantum algorithms, from state preparation to the number of measurements needed to obtain good statistics from the final states of the quantum system, in order to assess the overall space and time costs of the processes.
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| 10. |
- Chintada, Bhaskara R., et al.
(författare)
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Phase-Aberration Correction in Shear-Wave Elastography Imaging Using Local Speed-of-Sound Adaptive Beamforming
- 2021
-
Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Shear wave elasticity imaging (SWEI) is a non-invasive imaging modality that provides tissue elasticity information by measuring the travelling speed of an induced shear-wave. It is commercially available on clinical ultrasound scanners and popularly used in the diagnosis and staging of liver disease and breast cancer. In conventional SWEI methods, a sequence of acoustic radiation force (ARF) pushes are used for inducing a shear-wave, which is tracked using high frame-rate multi-angle plane wave imaging (MA-PWI) to estimate the shear-wave speed (SWS). Conventionally, these plane waves are beamformed using a constant speed-of-sound (SoS), assuming an a-priori known and homogeneous tissue medium. However, soft tissues are inhomogeneous, with intrinsic SoS variations. In this work, we study the SoS effects and inhomogeneities on SWS estimation, using simulation and phantoms experiments with porcine muscle as an abbarator, and show how these aberrations can be corrected using local speed-of-sound adaptive beamforming. For shear-wave tracking, we compare standard beamform with spatially constant SoS values to software beamforming with locally varying SoS maps. We show that, given SoS aberrations, traditional beamforming using a constant SoS, regardless of the utilized SoS value, introduces a substantial bias in the resulting SWS estimations. Average SWS estimation disparity for the same material was observed over 4.3 times worse when a constant SoS value is used compared to that when a known SoS map is used for beamforming. Such biases are shown to be corrected by using a local SoS map in beamforming, indicating the importance of and the need for local SoS reconstruction techniques.
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| 11. |
- Chintada, Bhaskara Rao, et al.
(författare)
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Spectral Ultrasound Imaging of Speed-of-Sound and Attenuation Using an Acoustic Mirror
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Speed-of-sound and attenuation of ultrasound waves vary in the tissues. There exist methods in the literature that allow for spatially reconstructing the distribution of group speed-of-sound (SoS) and frequency-dependent ultrasound attenuation (UA) using reflections from an acoustic mirror positioned at a known distance from the transducer. These methods utilize a conventional ultrasound transducer operating in pulse-echo mode and a calibration protocol with measurements in water. In this study, we introduce a novel method for reconstructing local SoS and UA maps as a function of acoustic frequency through Fourier-domain analysis and by fitting linear and power-law dependency models in closed form. Frequency-dependent SoS and UA together characterize the tissue comprehensively in spectral domain within the utilized transducer bandwidth. In simulations, our proposed methods are shown to yield low reconstruction error: 0.01 dB/cm.MHz(y) for attenuation coefficient and 0.05 for the frequency exponent. For tissue-mimicking phantoms and ex-vivo bovine muscle samples, a high reconstruction contrast was achieved. Attenuation exponents in a gelatin-cellulose mixture and an ex-vivo bovine muscle sample were found to be, respectively, 1.3 and 0.6 on average. Linear dispersion of SoS in a gelatin-cellulose mixture and an ex-vivo bovine muscle sample were found to be, respectively, 1.3 and 4.0 m/s.MHz on average. These findings were reproducible when the inclusion and substrate materials were exchanged. Bulk loss modulus in the bovine muscle sample was computed to be approximately 4 times the bulk loss modulus in the gelatin-cellulose mixture. Such frequency-dependent characteristics of SoS and UA, and bulk loss modulus may therefore differentiate tissues as potential diagnostic biomarkers.
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| 12. |
- Colangeli, M., et al.
(författare)
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Reduced Markovian descriptions of Brownian dynamics : Toward an exact theory
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- We outline a reduction scheme for a class of Brownian dynamics which leads to meaningful corrections to the Smoluchowski equation in the overdamped regime. The mobility coefficient of the reduced dynamics is obtained by exploiting the Dynamic Invariance principle, whereas the diffusion coefficient fulfils the Fluctuation-Dissipation theorem. Explicit calculations are carried out in the case of a harmonically bound particle. A quantitative pointwise representation of the reduction error is also provided and connections to both the Maximum Entropy method and the linear response theory are highlighted. Our study paves the way to the development of reduction procedures applicable to a wider class of diffusion processes.
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| 13. |
- Dabelow, Lennart, et al.
(författare)
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Irreversibility in Active Matter : General Framework for Active Ornstein-Uhlenbeck Particles
- 2021
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 8
-
Tidskriftsartikel (refereegranskat)abstract
- Active matter systems are driven out of equilibrium by conversion of energy into directed motion locally on the level of the individual constituents. In the spirit of a minimal description, active matter is often modeled by so-called active Ornstein-Uhlenbeck particles an extension of passive Brownian motion where activity is represented by an additional fluctuating non-equilibrium "force" with simple statistical properties (Ornstein-Uhlenbeck process). While in passive Brownian motion, entropy production along trajectories is well-known to relate to irreversibility in terms of the log-ratio of probabilities to observe a certain particle trajectory forward in time in comparison to observing its time-reversed twin trajectory, the connection between these concepts for active matter is less clear. It is therefore of central importance to provide explicit expressions for the irreversibility of active particle trajectories based on measurable quantities alone, such as the particle positions. In this technical note we derive a general expression for the irreversibility of AOUPs in terms of path probability ratios (forward vs. backward path), extending recent results from [PRX 9, 021009 (2019)] by allowing for arbitrary initial particle distributions and states of the active driving.
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| 14. |
- Dai, Lei, et al.
(författare)
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AME : A Cross-Scale Constellation of CubeSats to Explore Magnetic Reconnection in the Solar-Terrestrial Relation
- 2020
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 8
-
Tidskriftsartikel (refereegranskat)abstract
- A major subset of solar-terrestrial relations, responsible, in particular, for the driver of space weather phenomena, is the interaction between the Earth's magnetosphere and the solar wind. As one of the most important modes of the solar-wind-magnetosphere interaction, magnetic reconnection regulates the energy transport and energy release in the solar-terrestrial relation. In situ measurements in the near-Earth space are crucial for understanding magnetic reconnection. Past and existing spacecraft constellation missions mainly focus on the measurement of reconnection on plasma kinetic-scales. Resolving the macro-scale and cross-scale aspects of magnetic reconnection is necessary for accurate assessment and predictions of its role in the context of space weather. Here, we propose the AME (self-Adaptive Magnetic reconnection Explorer) mission consisting of a cross-scale constellation of 12+ CubeSats and one mother satellite. Each CubeSat is equipped with instruments to measure magnetic fields and thermal plasma particles. With multiple CubeSats, the AME constellation is intended to make simultaneous measurements at multiple scales, capable of exploring cross-scale plasma processes ranging from kinetic scale to macro scale.
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| 15. |
- de Boer, Jan, et al.
(författare)
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Carroll Symmetry, Dark Energy and Inflation
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Carroll symmetry arises from Poincare symmetry upon taking the limit of vanishing speed of light. We determine the constraints on the energy-momentum tensor implied by Carroll symmetry and show that for energy-momentum tensors of perfect fluid form, these imply an equation of state epsilon + P = 0 for energy density plus pressure. Therefore Carroll symmetry might be relevant for dark energy and inflation. In the Carroll limit, the Hubble radius goes to zero and outside it recessional velocities are naturally large compared to the speed of light. The de Sitter group of isometries, after the limit, becomes the conformal group in Euclidean flat space. We also study the Carroll limit of chaotic inflation, and show that the scalar field is naturally driven to have an equation of state with w = - 1. Finally we show that the freeze-out of scalar perturbations in the two point function at horizon crossing is a consequence of Carroll symmetry. To make the paper self-contained, we include a brief pedagogical review of Carroll symmetry, Carroll particles and Carroll field theories that contains some new material as well. In particular we show, using an expansion around speed of light going to zero, that for scalar and Maxwell type theories one can take two different Carroll limits at the level of the action. In the Maxwell case these correspond to the electric and magnetic limit. For point particles we show that there are two types of Carroll particles: those that cannot move in space and particles that cannot stand still.
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| 16. |
- Ekström, Andreas, 1980
(författare)
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Analyzing the Nuclear Interaction: Challenges and New Ideas
- 2020
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 8
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Forskningsöversikt (refereegranskat)abstract
- This review presents some of the challenges in constructing models of atomic nuclei starting from theoretical descriptions of the strong interaction between nucleons. The focus is on statistical computing and methods for analyzing the link between bulk properties of atomic nuclei, such as radii and binding energies, and the underlying microscopic description of the nuclear interaction. The importance of careful model calibration and uncertainty quantification of theoretical predictions is highlighted.
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| 17. |
- Ekström, Andreas, 1980, et al.
(författare)
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What is ab initio in nuclear theory?
- 2023
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 11
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Forskningsöversikt (refereegranskat)abstract
- Ab initio has been used as a label in nuclear theory for over two decades. Its meaning has evolved and broadened over the years. We present our interpretation, briefly review its historical use, and discuss its present-day relation to theoretical uncertainty quantification.
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| 18. |
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| 19. |
- Garg, D., et al.
(författare)
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Fragmentation Dynamics of Fluorene Explored Using Ultrafast XUV-Vis Pump-Probe Spectroscopy
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- We report on the use of extreme ultraviolet (XUV, 30.3 nm) radiation from the Free-electron LASer in Hamburg (FLASH) and visible (Vis, 405 nm) photons from an optical laser to investigate the relaxation and fragmentation dynamics of fluorene ions. The ultrashort laser pulses allow to resolve the molecular processes occurring on the femtosecond timescales. Fluorene is a prototypical small polycyclic aromatic hydrocarbon (PAH). Through their infrared emission signature, PAHs have been shown to be ubiquitous in the universe, and they are assumed to play an important role in the chemistry of the interstellar medium. Our experiments track the ionization and dissociative ionization products of fluorene through time-of-flight mass spectrometry and velocity-map imaging. Multiple processes involved in the formation of each of the fragment ions are disentangled through analysis of the ion images. The relaxation lifetimes of the excited fluorene monocation and dication obtained through the fragment formation channels are reported to be in the range of a few tens of femtoseconds to a few picoseconds.
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| 20. |
- Gassner, Gregor J., et al.
(författare)
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A Novel Robust Strategy for Discontinuous Galerkin Methods in Computational Fluid Mechanics: Why? When? What? Where?
- 2021
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Ingår i: Frontiers in Physics. - : FRONTIERS MEDIA SA. - 2296-424X. ; 8
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Forskningsöversikt (refereegranskat)abstract
- In this paper we will review a recent emerging paradigm shift in the construction and analysis of high order Discontinuous Galerkin methods applied to approximate solutions of hyperbolic or mixed hyperbolic-parabolic partial differential equations (PDEs) in computational physics. There is a long history using DG methods to approximate the solution of partial differential equations in computational physics with successful applications in linear wave propagation, like those governed by Maxwells equations, incompressible and compressible fluid and plasma dynamics governed by the Navier-Stokes and the Magnetohydrodynamics equations, or as a solver for ordinary differential equations (ODEs), e.g., in structural mechanics. The DG method amalgamates ideas from several existing methods such as the Finite Element Galerkin method (FEM) and the Finite Volume method (FVM) and is specifically applied to problems with advection dominated properties, such as fast moving fluids or wave propagation. In the numerics community, DG methods are infamous for being computationally complex and, due to their high order nature, as having issues with robustness, i.e., these methods are sometimes prone to crashing easily. In this article we will focus on efficient nodal versions of the DG scheme and present recent ideas to restore its robustness, its connections to and influence by other sectors of the numerical community, such as the finite difference community, and further discuss this young, but rapidly developing research topic by highlighting the main contributions and a closing discussion about possible next lines of research.
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| 21. |
- Gedalin, Michael, et al.
(författare)
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Theory Helps Observations : Determination of the Shock Mach Number and Scales From Magnetic Measurements
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- The Mach number is one of the key parameters of collisionless shocks. Understanding shock physics requires knowledge of the spatial scales in the shock transition layer. The standard methods of determining the Mach number and the spatial scales require simultaneous measurements of the magnetic field and the particle density, velocity, and temperature. While magnetic field measurements are usually of high quality and resolution, particle measurements are often either unavailable or not properly adjusted to the plasma conditions. We show that theoretical arguments can be used to overcome the limitations of observations and determine the Mach number and spatial scales of the low-Mach number shock when only magnetic field data are available.
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| 22. |
- Geilhufe, Matthias, et al.
(författare)
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GTPack : A Mathematica Group Theory Package for Application in Solid-State Physics and Photonics
- 2018
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Ingår i: Frontiers in Physics. - : FRONTIERS MEDIA SA. - 2296-424X. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- We present the Mathematica group theory package GTPack providing about 200 additional modules to the standard Mathematica language. The content ranges from basic group theory and representation theory to more applied methods like crystal field theory, tight-binding and plane-wave approaches capable for symmetry based studies in the fields of solid-state physics and photonics. GTPack is freely available via http://GTPack.org. The package is designed to be easily accessible by providing a complete Mathematica-style documentation, an optional input validation and an error strategy. We illustrate the basic framework of the package and show basic examples to present the functionality. Furthermore, we give a complete list of the implemented commands including references for algorithms within the Supplementary Material.
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| 23. |
- Gerbino, Martina, et al.
(författare)
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Status of Neutrino Properties and Future Prospects-Cosmological and Astrophysical Constraints
- 2018
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 5
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Forskningsöversikt (refereegranskat)abstract
- Cosmological observations are a powerful probe of neutrino properties, and in particular of their mass. In this review, we first discuss the role of neutrinos in shaping the cosmological evolution at both the background and perturbation level, and describe their effects on cosmological observables such as the cosmic microwave background and the distribution of matter at large scale. We then present the state of the art concerning the constraints on neutrino masses from those observables, and also review the prospects for future experiments. We also briefly discuss the prospects for determining the neutrino hierarchy from cosmology, the complementarity with laboratory experiments, and the constraints on neutrino properties beyond their mass.
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| 24. |
- Giannakopoulos, Stavros, 1989, et al.
(författare)
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A 112 Gb/s radiation-hard mid-board optical transceiver in 130 nm SiGe BiCMOS for intra-satellite links
- 2021
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- We report the design of 112 Gb/s radiation-hard (RH) optical transceiver applicable to intra-satellite optical interconnects. The transceiver chipset comprises of VCSEL driver and transimpedance amplifier (TIA) ICs integrated with four channels per die, which are adapted for flip-chip assembly into a mid-board optics (MBO) optical transceiver module. The ICs are designed in the IHP 130nm SiGe BiCMOS process (SG13RH) leveraging proven robustness in radiation environments and high-speed performance featuring bipolar transistors (HBTs) with fT/ fMAX values of up to 250/340 GHz. Besides hardening-by-technology, radiation-hardened-by-design (RHBD) components are used, including enclosed layout transistors (ELT) and digital logic cells. We report design features of the ICs and module and provide performance data from post-layout simulations. We present radiation evaluation data on the analogue devices and digital cells, which indicate that the transceiver ICs would operate under typical total ionizing dose (TID) levels and single event latch-up thresholds found in geostationary satellites.
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| 25. |
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| 26. |
- Graafsma, Heinz, et al.
(författare)
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Detector developments for photon science at DESY
- 2023
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- The past, current and planned future developments of X-ray imagers in the Photon-Science Detector Group at DESY-Hamburg is presented. the X-ray imagers are custom developed and tailored to the different X-ray sources in Hamburg, including the storage ring PETRA III/IV; the VUV-soft X-ray free electron laser FLASH, and the European Free-Electron Laser. Each source puts different requirements on the X-ray detectors, which is described in detail, together with the technical solutions implemented.
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| 27. |
- Gurchumelia, Alexandre, et al.
(författare)
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Comparing Quasi-Parallel and Quasi-Perpendicular Configuration in the Terrestrial Magnetosheath : Multifractal Analysis
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- The terrestrial magnetosheath is characterized by large-amplitude magnetic field fluctuations. In some regions, and depending on the bow-shock geometry, these can be observed on several scales, and show the typical signatures of magnetohydrodynamic turbulence. Using Cluster data, magnetic field spectra and flatness are observed in two intervals separated by a sharp transition from quasi-parallel to quasi-perpendicular magnetic field with respect to the bow-shock normal. The multifractal generalized dimensions D-q and the corresponding multifractal spectrum f(alpha) were estimated using a coarse-graining method. A p-model fit was used to obtain a single parameter to describe quantitatively the strength of multifractality and intermittency. Results show a clear transition and sharp differences in the intermittency properties for the two regions, with the quasi-parallel turbulence being more intermittent.
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| 28. |
- Hartong, Jelle, et al.
(författare)
-
Review on non-relativistic gravity
- 2023
-
Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 11
-
Forskningsöversikt (refereegranskat)abstract
- This study reviews the history of Newton–Cartan (NC) gravity with an emphasis on recent developments, including the covariant, off-shell large speed of light expansion of general relativity. Depending on the matter content, this expansion leads to either NC geometry with absolute time or NC geometry with non-relativistic gravitational time dilation effects. The latter shows that non-relativistic gravity (NRG) includes a strong field regime and goes beyond Newtonian gravity. We start by reviewing early developments in NC geometry, including the covariant description of Newtonian gravity, mainly through the works of Trautman, Dautcourt, Künzle, and Ehlers. We then turn to more modern developments, such as the gauging of the Bargmann algebra and describe why the latter cannot be used to find an off-shell covariant description of Newtonian gravity. We review recent work on the 1/c expansion of general relativity and show that this leads to an alternative “type II” notion of NC geometry. Finally, we discuss matter couplings, solutions, and odd powers in 1/c and conclude with a brief summary of related topics.
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| 29. |
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| 30. |
- Henthorn, Nicholas T., et al.
(författare)
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Mapping the Future of Particle Radiobiology in Europe : The INSPIRE Project
- 2020
-
Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 8
-
Tidskriftsartikel (refereegranskat)abstract
- Particle therapy is a growing cancer treatment modality worldwide. However, there still remains a number of unanswered questions considering differences in the biological response between particles and photons. These questions, and probing of biological mechanisms in general, necessitate experimental investigation. The "Infrastructure in Proton International Research" (INSPIRE) project was created to provide an infrastructure for European research, unify research efforts on the topic of proton and ion therapy across Europe, and to facilitate the sharing of information and resources. This work highlights the radiobiological capabilities of the INSPIRE partners, providing details of physics (available particle types and energies), biology (sample preparation and post-irradiation analysis), and researcher access (the process of applying for beam time). The collection of information reported here is designed to provide researchers both in Europe and worldwide with the tools required to select the optimal center for their research needs. We also highlight areas of redundancy in capabilities and suggest areas for future investment.
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| 31. |
- Herrera-Velarde, Salvador, et al.
(författare)
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Stability and structural evolution of double-stranded DNA molecules under high pressures : A molecular dynamics study
- 2023
-
Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- Conformational changes and stability of interacting double-stranded DNA chains under high hydrostatic pressure in biological systems are striking topics of importance to study several biomolecular phenomena. For example, to unravel the physiological conditions at which life might occur and to ensure the right functionality of the biochemical processes into the cell under extreme thermodynamic conditions. Furthermore, such processes could shed light on the physicochemical properties of the DNA under high confinement and how, through different mechanisms, a virus releases its genome in order to infect a cell and, therefore, to promote the process of viral replication. To achieve a few steps toward this direction, we propose an all-atomistic molecular dynamics approach in the NPT isothermal-isobaric ensemble to account for how the interplay of DNA—DNA interaction, hydrogen bonding, and the hydrostatic pressure modifies both the DNA conformational degrees of freedom and the spatial organization of the DNA chains in the available volume. We consider two interacting double-stranded DNA chains immersed in an explicit aqueous solution, i.e., water and ions. Our preliminary results highlight the role of hydrogen bonding and electrostatic interactions between DNA strands to avoid denaturation and, therefore, to provide mechanical stability for the DNA molecules. However, the structural evolution, whose kinetics depends on the relaxation of the stresses induced by the pressure, indicates that almost in all pressure conditions, the equilibrium configuration corresponds to an alignment of the two double-stranded DNA molecules along their main axis of symmetry; the rearrangement between the two approaching DNA dodecamers does not always correspond to complementary base pairs and becomes a function of the thermodynamic conditions.
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| 32. |
- Holme, Petter, et al.
(författare)
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Mechanistic models in computational social science
- 2015
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 3
-
Forskningsöversikt (refereegranskat)abstract
- Quantitative social science is not only about regression analysis or, in general, data inference. Computer simulations of social mechanisms have an over 60 years long history. They have been used for many different purposes to test scenarios, to test the consistency of descriptive theories (proof-of-concept models), to explore emergent phenomena, for forecasting, etc... In this essay, we sketch these historical developments, the role of mechanistic models in the social sciences and the influences from the natural and formal sciences. We argue that mechanistic computational models form a natural common ground for social and natural sciences, and look forward to possible future information flow across the social-natural divide.
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| 33. |
- Iqbal, Muhammad, et al.
(författare)
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Symbol error rate minimization using deep learning approaches for short-reach optical communication networks
- 2024
-
Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 12
-
Tidskriftsartikel (refereegranskat)abstract
- Short-reach optical communication networks have various applications in areas where high-speed connectivity is needed, for example, inter- and intra-data center links, optical access networks, and indoor and in-building communication systems. Machine learning (ML) approaches provide a key solution for numerous challenging situations due to their robust decision-making, problem-solving, and pattern-recognition abilities. In this work, our focus is on utilizing deep learning models to minimize symbol error rates in short-reach optical communication setups. Various channel impairments, such as nonlinearity, chromatic dispersion (CD), and attenuation, are accurately modeled. Initially, we address the challenge of modeling a nonlinear channel. Consequently, we harness a deep learning model called autoencoders (AEs) to facilitate communication over nonlinear channels. Furthermore, we investigate how the inclusion of a nonlinear channel within an autoencoder influences the received constellation as the optical fiber length increases. Another facet of our work involves the deployment of a deep neural network-based receiver utilizing a channel influenced by chromatic dispersion. By gradually extending the optical length, we explore its impact on the received constellation and, consequently, the symbol error rate. Finally, we incorporate the split-step Fourier method (SSFM) to emulate the combined effects of nonlinearities, chromatic dispersion, and attenuation in the optical channel. This is accomplished through a neural network-based receiver. The outcome of this work is an evaluation and reduction of the symbol error rate as the length of the optical fiber is varied.
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| 34. |
- Izzo, Maria G., et al.
(författare)
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The Mixing of Polarizations in the Acoustic Excitations of Disordered Media With Local Isotropy
- 2018
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- An approximate solution of the Dyson equation related to a stochastic Helmholtz equation, which describes the acoustic dynamics of a three-dimensional isotropic random medium with elastic tensor fluctuating in space, is obtained in the framework of the Random Media Theory. The wavevector-dependence of the self-energy is preserved, thus allowing a description of the acoustic dynamics at wavelengths comparable with the size of heterogeneity domains. This in turn permits to quantitatively describe the mixing of longitudinal and transverse dynamics induced by the medium's elastic heterogeneity and occurring at such wavelengths. A functional analysis aimed to attest the mathematical coherence and to define the region of validity in the frequency-wavector plane of the proposed approximate solution is presented, with particular emphasis dedicated to the case of disorder characterized by an exponential decay of the covariance function.
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| 35. |
- Jiang, Weiguang, 1989, et al.
(författare)
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Bayesian probability updates using sampling/importance resampling: Applications in nuclear theory
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- We review an established Bayesian sampling method called sampling/importance resampling and highlight situations in nuclear theory when it can be particularly useful. To this end we both analyse a toy problem and demonstrate realistic applications of importance resampling to infer the posterior distribution for parameters of ΔNNLO interaction model based on chiral effective field theory and to estimate the posterior probability distribution of target observables. The limitation of the method is also showcased in extreme situations where importance resampling breaks.
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| 36. |
- Kamal, Mohammad Arif, et al.
(författare)
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Physics of Organelle Membrane Bridging via Cytosolic Tethers is Distinct From Cell Adhesion
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Tremendous progress has been made recently in imaging the contacts between intra-cellular organelles, which are thought to be mediated by soluble tethers. However, they are still difficult to study in cellulo, and reconstituting them in vitro is a standing challenge. Here we take a mimetic approach to study Giant unilamellar vesicles (GUVs) and supported lipid bilayers (SLBs) interacting via single- (or double-) stranded DNA sequences of two different lengths. Like intra-cellular tethers which may reside in the cytosol when unbound, the DNA-tethers are soluble, but can insert into the membrane with the help of cholesterol moieties found at their extremities. Tether-exchange between the bulk “cytosol” and the GUV/SLB membrane leads to a novel statistical ensemble in which the entire system equilibrates together, rather than individual GUVs behaving as separate closed systems. As a consequence, adhesion between the GUV and the SLB is driven by collective entropic effects amplified by tether shape changes associated with membrane bridging. A direct experimental consequence is an unusual dependence on tether-concentration, which becomes an important control parameter at low concentrations, while tether length/flexibility are less important. The establishment of this fundamentally different interaction between two membranes suggests that in physiological conditions, the regulation of contact formation inside cells may be very different from the case of the much studied ligand-receptor mediated cell adhesion.
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| 37. |
- Khrennikov, Andrei
(författare)
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Quantum-like modeling of cognition
- 2015
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 3
-
Tidskriftsartikel (refereegranskat)abstract
- This paper begins with a historical review of the mutual influence of physics and psychology, from Freud's invention of psychic energy inspired by von Boltzmann' thermodynamics to the enrichment quantum physics gained from the side of psychology by the notion of complementarity (the invention of Niels Bohr who was inspired by William James), besides we consider the resonance of the correspondence between Wolfgang Pauli and Carl Jung in both physics and psychology. Then we turn to the problem of development of mathematical models for laws of thought starting with Boolean logic and progressing toward foundations of classical probability theory. Interestingly, the laws of classical logic and probability are routinely violated not only by quantum statistical phenomena but by cognitive phenomena as well. This is yet another common feature between quantum physics and psychology. In particular, cognitive data can exhibit a kind of the probabilistic interference effect. This similarity with quantum physics convinced a multi-disciplinary group of scientists (physicists, psychologists, economists, sociologists) to apply the mathematical apparatus of quantum mechanics to modeling of cognition. We illustrate this activity by considering a few concrete phenomena: the order and disjunction effects, recognition of ambiguous figures, categorization-decision making. In Appendix 1 of Supplementary Material we briefly present essentials of theory of contextual probability and a method of representations of contextual probabilities by complex probability amplitudes (solution of the “inverse Born's problem”) based on a quantum-like representation algorithm (QLRA).
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| 38. |
- Kuchkin, Vladyslav M., et al.
(författare)
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Heliknoton in a film of cubic chiral magnet
- 2023
-
Ingår i: Frontiers in Physics. - : FRONTIERS MEDIA SA. - 2296-424X. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- Cubic chiral magnets exhibit a remarkable diversity of two-dimensional topological magnetic textures, including skyrmions. However, the experimental confirmation of topological states localized in all three spatial dimensions remains challenging. In this paper, we investigate a three-dimensional topological state called a heliknoton, which is a hopfion embedded into a helix or conic background. We explore the range of parameters at which the heliknoton can be stabilized under realistic conditions using micromagnetic modeling, harmonic transition state theory, and stochastic spin dynamics simulations. We present theoretical Lorentz TEM images of the heliknoton, which can be used for experimental comparison. Additionally, we discuss the stability of the heliknoton at finite temperatures and the mechanism of its collapse. Our study offers a pathway for future experimental investigations of three-dimensional topological solitons in magnetic crystals.
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| 39. |
- Kuchkin, Vladyslav M., et al.
(författare)
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Tailed skyrmions : An obscure branch of magnetic solitons
- 2023
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Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- We report tailed skyrmions-a new class of stable soliton solutions of the 2D chiral magnet model. Tailed skyrmions have elongated shapes and emerge in a narrow range of fields near the transition between the spin spirals and the saturated state. We analyze the stability range of these solutions in terms of external magnetic field and magnetocrystalline anisotropy. We calculate minimum energy paths and homotopies (continuous transitions) between tailed skyrmions of the same topological charge. The discovery of tailed skyrmions extends the diversity of already known solutions. This is illustrated by solitons with complex morphology, such as tailed skyrmion bags with and without chiral kinks.
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| 40. |
- Lasič, Samo, et al.
(författare)
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Microanisotropy imaging : Quantification of microscopic diffusion anisotropy and orientational order parameter by diffusion MRI with magic-angle spinning of the q-vector
- 2014
-
Ingår i: Frontiers of Physics. - : Frontiers Media SA. - 2095-0462 .- 2296-424X. ; 2, s. 1-14
-
Tidskriftsartikel (refereegranskat)abstract
- Diffusion tensor imaging (DTI) is the method of choice for non-invasive investigations of the structure of human brain white matter (WM). The results are conventionally reported as maps of the fractional anisotropy (FA), which is a parameter related to microstructural features such as axon density, diameter, and myelination. The interpretation of FA in terms of microstructure becomes ambiguous when there is a distribution of axon orientations within the image voxel. In this paper, we propose a procedure for resolving this ambiguity by determining a new parameter, the microscopic fractional anisotropy (μFA), which corresponds to the FA without the confounding influence of orientation dispersion. In addition, we suggest a method for measuring the orientational order parameter (OP) for the anisotropic objects. The experimental protocol is capitalizing on a recently developed diffusion nuclear magnetic resonance (NMR) pulse sequence based on magic-angle spinning of the q-vector. Proof-of-principle experiments are carried out on microimaging and clinical MRI equipment using lyotropic liquid crystals and plant tissues as model materials with high μFA and low FA on account of orientation dispersion. We expect the presented method to be especially fruitful in combination with DTI and high angular resolution acquisition protocols for neuroimaging studies of gray and white matter.
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| 41. |
- Lasič, Samo, et al.
(författare)
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Stay on the Beat With Tensor-Valued Encoding: Time-Dependent Diffusion and Cell Size Estimation in ex vivo Heart
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Diffusion encoding with free gradient waveforms can provide increased microstructural specificity in heterogeneous tissues compared to conventional encoding approaches. This is achieved by considering specific aspects of encoding, such as b-tensor shape, sensitivity to bulk motion and to time-dependent diffusion (TDD). In tensor-valued encoding, different b-tensor shapes are used, such as in linear tensor encoding (LTE) or spherical tensor encoding (STE). STE can be employed for estimation of mean diffusivity (MD) or in combination with LTE to probe average microscopic anisotropy unconfounded by orientation dispersion. While tensor-valued encoding has been successfully applied in the brain and other organs, its potential and limitations have not yet been fully explored in cardiac applications. To avoid artefacts due to motion, which are particularly challenging in cardiac imaging, arbitrary b-tensors can be designed with motion compensation, i.e. gradient moment nulling, while also nulling the adverse effects of concomitant gradients. Encoding waveforms with varying degrees of motion compensation may however have significantly different sensitivities to TDD. This effect can be prominent in tissues with relatively large cell sizes such as in the heart and can be used advantageously to provide further tissue information. To account for TDD in tensor-valued encoding, the interplay between asynchronous gradients simultaneously applied along different directions needs to be considered. As the first step toward in vivo cardiac applications, our overarching goal was to explore the feasibility of acceleration compensated tensor-valued encoding on preclinical and clinical scanners ex vivo. We have demonstrated strong and predictable variation of MD due to TDD in mouse and pig hearts using a wide range of LTE and STE with progressively increasing degrees of motion compensation. Our preliminary data from acceleration compensated STE and LTE at high b-values, attainable on the preclinical scanner, indicate that TDD needs to be considered in experiments with varying b-tensor shapes. We have presented a novel theoretical framework, which enables cell size estimation, helps to elucidate limitations and provides a basis for further optimizations of experiments probing both mean diffusivity and microscopic anisotropy in the heart.
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| 42. |
- Li, Kun, et al.
(författare)
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High-Latitude Cold Ion Outflow Inferred From the Cluster Wake Observations in the Magnetotail Lobes and the Polar Cap Region
- 2021
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Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 9
-
Forskningsöversikt (refereegranskat)abstract
- Cold ions with low (a few eV) thermal energies and also often low bulk drift energies, dominate the ion population in the Earth's magnetosphere. These ions mainly originate from the ionosphere. Here we concentrate on cold ions in the high latitude polar regions, where magnetic field lines are open and connected to the magnetotail. Outflow from the ionosphere can modify the dynamics of the magnetosphere. In-situ observations of low energy ions are challenging. In the low-density polar regions the equivalent spacecraft potential is often large compared to cold ion energies and the ions cannot reach the spacecraft. Rather, a supersonic ion flow creates an enhanced wake. The local electric field associated with this wake can be used to detect the drifting cold ions, and this wake technique can be used for statistical studies. In this paper, we review some of the key results obtained from this technique. These results help us to understand how cold ionospheric outflow varies with various conditions of solar activities and the Earth's intrinsic magnetic field.
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| 43. |
- Markidis, Stefano, et al.
(författare)
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PolyPIC : The polymorphic-particle-in-cell method for fluid-kinetic coupling
- 2018
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Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 6:OCT
-
Tidskriftsartikel (refereegranskat)abstract
- Particle-in-Cell (PIC) methods are widely used computational tools for fluid and kinetic plasma modeling. While both the fluid and kinetic PIC approaches have been successfully used to target either kinetic or fluid simulations, little was done to combine fluid and kinetic particles under the same PIC framework. This work addresses this issue by proposing a new PIC method, PolyPIC, that uses polymorphic computational particles. In this numerical scheme, particles can be either kinetic or fluid, and fluid particles can become kinetic when necessary, e.g., particles undergoing a strong acceleration. We design and implement the PolyPIC method, and test it against the Landau damping of Langmuir and ion acoustic waves, two stream instability and sheath formation. We unify the fluid and kinetic PIC methods under one common framework comprising both fluid and kinetic particles, providing a tool for adaptive fluid-kinetic coupling in plasma simulations.
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| 44. |
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| 45. |
- Narvaez, Omar, et al.
(författare)
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Massively Multidimensional Diffusion-Relaxation Correlation MRI
- 2022
-
Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Diverse approaches such as oscillating gradients, tensor-valued encoding, and diffusion-relaxation correlation have been used to study microstructure and heterogeneity in healthy and pathological biological tissues. Recently, acquisition schemes with free gradient waveforms exploring both the frequency-dependent and tensorial aspects of the encoding spectrum b(ω) have enabled estimation of nonparametric distributions of frequency-dependent diffusion tensors. These “D(ω)-distributions” allow investigation of restricted diffusion for each distinct component resolved in the diffusion tensor trace, anisotropy, and orientation dimensions. Likewise, multidimensional methods combining longitudinal and transverse relaxation rates, R1 and R2, with (ω-independent) D-distributions capitalize on the component resolution offered by the diffusion dimensions to investigate subtle differences in relaxation properties of sub-voxel water populations in the living human brain, for instance nerve fiber bundles with different orientations. By measurements on an ex vivo rat brain, we here demonstrate a “massively multidimensional” diffusion-relaxation correlation protocol joining all the approaches mentioned above. Images acquired as a function of the magnitude, normalized anisotropy, orientation, and frequency content of b(ω), as well as the repetition time and echo time, yield nonparametric D(ω)-R1-R2-distributions via a Monte Carlo data inversion algorithm. The obtained per-voxel distributions are converted to parameter maps commonly associated with conventional lower-dimensional methods as well as unique statistical descriptors reporting on the correlations between restriction, anisotropy, and relaxation.
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| 46. |
- Neoričić, L., et al.
(författare)
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Resonant two-photon ionization of helium atoms studied by attosecond interferometry
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- We study resonant two-photon ionization of helium atoms via the 1s3p, 1s4p and 1s5p P-1(1) states using the 15(th) harmonic of a titanium-sapphire laser for the excitation and a weak fraction of the laser field for the ionization. The phase of the photoelectron wavepackets is measured by an attosecond interferometric technique, using the 17(th) harmonic. We perform experiments with angular resolution using a velocity map imaging spectrometer and with high energy resolution using a magnetic bottle electron spectrometer. Our results are compared to calculations using the two-photon random phase approximation with exchange to account for electron correlation effects. We give an interpretation for the multiple pi-rad phase jumps observed, both at and away from resonance, as well as their dependence on the emission angle.
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| 47. |
- Norbury, John W., et al.
(författare)
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Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles
- 2020
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 8
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Forskningsöversikt (refereegranskat)abstract
- The helium ((Formula presented.) He) component of the primary particles in the galactic cosmic ray spectrum makes significant contributions to the total astronaut radiation exposure. (Formula presented.) He ions are also desirable for direct applications in ion therapy. They contribute smaller projectile fragmentation than carbon ((Formula presented.) C) ions and smaller lateral beam spreading than protons. Space radiation protection and ion therapy applications need reliable nuclear reaction models and transport codes for energetic particles in matter. Neutrons and light ions ((Formula presented.) H, (Formula presented.) H, (Formula presented.) H, (Formula presented.) He, and (Formula presented.) He) are the most important secondary particles produced in space radiation and ion therapy nuclear reactions; these particles penetrate deeply and make large contributions to dose equivalent. Since neutrons and light ions may scatter at large angles, double differential cross sections are required by transport codes that propagate radiation fields through radiation shielding and human tissue. This work will review the importance of (Formula presented.) He projectiles to space radiation and ion therapy, and outline the present status of neutron and light ion production cross section measurements and modeling, with recommendations for future needs.
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| 48. |
- Oling, Gerben, et al.
(författare)
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Aspects of Nonrelativistic Strings
- 2022
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 10
-
Forskningsöversikt (refereegranskat)abstract
- We review recent developments on nonrelativistic string theory. In flat spacetime, the theory is defined by a two-dimensional relativistic quantum field theory with nonrelativistic global symmetries acting on the worldsheet fields. This theory arises as a self-contained corner of relativistic string theory. It has a string spectrum with a Galilean dispersion relation, and a spacetime S-matrix with nonrelativistic symmetry. This string theory also gives a unitary and ultraviolet complete framework that connects different corners of string theory, including matrix string theory and noncommutative open strings. In recent years, there has been a resurgence of interest in the non-Lorentzian geometries and quantum field theories that arise from nonrelativistic string theory in background fields. In this review, we start with an introduction to the foundations of nonrelativistic string theory in flat spacetime. We then give an overview of recent progress, including the appropriate target-space geometry that nonrelativistic strings couple to. This is known as (torsional) string Newton-Cartan geometry, which is neither Lorentzian nor Riemannian. We also give a review of nonrelativistic open strings and effective field theories living on D-branes. Finally, we discuss applications of nonrelativistic strings to decoupling limits in the context of the AdS/CFT correspondence.
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| 49. |
- Panchal, V., et al.
(författare)
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Local electric field screening in bi-layer graphene devices
- 2014
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Ingår i: Frontiers of Physics. - : Frontiers Media SA. - 2296-424X. ; 2, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- © 2014 Panchal, Giusca, Lartsev, Yakimova and Kazakova. We present experimental studies of both local and macroscopic electrical effects in uniform single- (1LG) and bi-layer graphene (2LG) devices as well as in devices with non-uniform graphene coverage, under ambient conditions. DC transport measurements on sub-micron scale Hall bar devices were used to show a linear rise in carrier density with increasing 2LG coverage. Electrical scanning gate microscopy was used to locally top gate uniform and non-uniform devices in order to observe the effect of local electrical gating. We experimentally show a significant level of electric field screening by 2LG. We demonstrate that SGM technique is an extremely useful research tool for studies of local screening effects, which provides a complementary view on phenomena that are usually considered only within a macroscopic experimental scheme.
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| 50. |
- Pennicard, David, et al.
(författare)
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Data reduction and processing for photon science detectors
- 2024
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Ingår i: Frontiers in Physics. - : Frontiers Media SA. - 2296-424X. ; 12
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Forskningsöversikt (refereegranskat)abstract
- New detectors in photon science experiments produce rapidly-growing volumes of data. For detector developers, this poses two challenges; firstly, raw data streams from detectors must be converted to meaningful images at ever-higher rates, and secondly, there is an increasing need for data reduction relatively early in the data processing chain. An overview of data correction and reduction is presented, with an emphasis on how different data reduction methods apply to different experiments in photon science. These methods can be implemented in different hardware (e.g., CPU, GPU or FPGA) and in different stages of a detector's data acquisition chain; the strengths and weaknesses of these different approaches are discussed.
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