| 1. |
- Chabot, Sophie, et al.
(författare)
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Impact of Cernitin™ on induced chronic prostatitis in animal model for understanding management of lower urinary tract symptoms
- 2021
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Ingår i: Phytomedicine Plus. - : Elsevier BV. - 2667-0313. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Cernitin™ pollen extracts (brand name Cernilton®) alleviates symptoms related to common lower uro-genital tract disorders in men. The underlying mechanisms are ill-defined but the inflammatory pathway could be one of them. In a previous in vitro study it was shown that Cernitin™ induce a regulatory effect on inflammatory parameters. Methods: In this study, male Sprague Dawley rats were used to validate the effects of Cernitin™ in chronic prostatitis and benign prostatic hyperplasia. Pain was assessed by von Frey assay. Results: Cernitin™ exhibited significant pain relief in the induced prostatitis rat model and was associated with a significant decrease in the intraprostatic level of COX-2 and MCP-1 in the prostatic tissue homogenates. In a parallel study, Cernitin™ treatment led to a significant decrease in prostate weight in rats with testosterone induced BPH. Concurrently, a significant decrease in the percentage of proliferation marker, Ki-67, and androgen receptor expressing cells was observed. Similarly, a low level of cytoplasmic 5α-reductase expression was observed in Cernitin™- and finasteride-treated animals. Conclusion: The current in vivo experiments support the use of Cernitin™ as an anti-inflammatory and symptom reducing agent that could, in part, explain the impact of Cernitin™ on the management of chronic pelvic pain in men.
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| 2. |
- Magtalas, M. C., et al.
(författare)
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A systematic review of ethnomedicinal plants used for pregnancy, childbirth, and postpartum care in the Philippines
- 2023
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Ingår i: Phytomedicine Plus. - : Elsevier BV. - 2667-0313. ; 3:1
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Forskningsöversikt (refereegranskat)abstract
- Background: Medicinal plants are still widely used in rural areas of the Philippines. Among the conditions treated with medicinal plants are those related to pregnancy, childbirth, and postpartum care. This systematic review identified the medicinal plants used for obstetric care in the country. Methods: The study was conducted based on the PRISMA flow diagram, starting with a data search using three databases. The necessary information was extracted from the eligible research papers, and the studies' quality was assessed through a developed quality assessment tool. Results: This study included 38 ethnobotanical studies with 153 plant species used for pregnancy and postpartum care. Most of the studies were conducted in Northern Mindanao, in the Philippines. The most common pregnancy-related indications for the medicinal plants were postpartum care, and postpartum bleeding topped the list. The most common plant family, genus, and species were Fabaceae, Ficus, and Moringa oleifera Lam, respectively. The leaf was the most common single plant part used for pregnancy and postpartum care. Only 80 medicinal plants had toxicologic and teratogenic data. Conclusion: Women from different ethnic groups widely utilized medicinal plants to treat pregnancy-related conditions. Further research on toxicology and teratogenicity is necessary to ensure the safety of their users.
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| 3. |
- Magtalas, M. C., et al.
(författare)
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A systematic review of medicinal plants used in the treatment of gynecologic diseases in the Philippines
- 2023
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Ingår i: Phytomedicine Plus. - : Elsevier. - 2667-0313. ; 3:3
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Forskningsöversikt (refereegranskat)abstract
- Background: Different indigenous peoples in the Philippines still utilize medicinal plants in treating gynecologic diseases. However, there is a lack of information regarding these medicinal plants used in treating gynecologic conditions in the Philippines. Hence, this systematic review compiled the available literature on medicinal plants used for gynecologic healthcare by various indigenous groups in the Philippines. Methods: Ethnobotanical studies that reported medicinal plants used for gynecologic diseases were obtained from OVID Medline, Scopus, and EBSCO CINAHL. A review of titles, abstracts, and articles was done independently by four reviewers. The quality of the studies was assessed using the quality assessment tool for ethnobotanical studies. Results: A total of 27 studies, including 98 different records, that cited the use of medicinal plants to treat gynecologic diseases were included in the qualitative synthesis. Most ethnobotanical studies were conducted in Northern Mindanao, Central Luzon, and Caraga, Philippines. The most common plant family, genus, and species were Fabaceae, Mimosa, and Mimosa pudica L., respectively. Leaves, roots, and stems were predominantly used, commonly prepared by decoction. Medicinal plants reported in ethnobotanical studies were widely used to treat dysmenorrhea (34 ssp.), irregular menstruation (28 spp.), myoma (four spp.), and infertility (four spp.). A significant proportion of medicinal plants used to treat gynecologic diseases in the Philippines had records of toxicologic (18 spp., 31.03%) or teratogenic (one sp., 1.72%) properties. Other species were reported as both nontoxic and toxic (five spp., 8.62%) and toxic and teratogenic (one sp., 1.72%). However, some were nontoxic or teratogenic (11 sp., 18.97%). In addition, 22 plant species had no data on toxicity or teratogenicity. Conclusion: This systematic review showed that medicinal plants and traditional healing practices are crucial in gynecologic healthcare in the Philippines.
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| 4. |
- Oskarsson, Agneta, et al.
(författare)
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Antiandrogenic activity and bioavailability of magnolol analogs – A potential for prostate cancer therapeutics
- 2023
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Ingår i: Phytomedicine Plus. - 2667-0313. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- Background: Prostate cancer is the second most common form of cancer in men worldwide and there is a great need for novel treatment strategies, especially for castrate-resistant prostate cancers where the proliferation of the cancer cells is stimulated by androgens produced in the adrenal cortex and the cancer cells. Purpose: In this study, we have investigated the antiandrogenic properties of magnolol and ten synthetic analogs in vitro. Study design and methods: The compounds were evaluated for cytotoxicity, antiandrogenic receptor activity, binding to the androgen receptor, effects on the production of Prostate-specific antigen (PSA), and potential to pass over a tight layer of Caco-2 cells mimicking gastrointestinal absorption. Results: We found that almost all investigated compounds were antiandrogenic in an androgen receptor reporter gene assay, with IC50 values ranging from 7 to 86 µM. Magnolol itself had the highest antiandrogenic potency. Five of the compounds were then evaluated for their binding to the androgen receptor and three of these compounds were found to bind to the receptor. These five compounds were also evaluated for their effect on the PSA production and four were found to decrease PSA production at non-cytotoxic concentrations. The antiandrogenic activity after passage through a layer of Caco-2 cells, mimicking gastrointestinal absorption, was also evaluated for three of the compounds. All three compounds were found to have the capacity to be transported from the apical to the basolateral side of the Caco-2 cell layer and exert antiandrogenic effects after the transport. Conclusion: In conclusion, this study shows that magnolol and analogs have antiandrogenic effects in vitro and that selected analogs can pass over a tight layer of Caco-2 cells, indicating a potential for good bioavailability after oral administration. These magnolol analogs thereby constitute an interesting group of compounds worthy of further evaluation as potential anti-prostate cancer therapeutics.
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