| 1. |
- Ahmed, Mobyen Uddin, Dr, 1976-, et al.
(författare)
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Study on Human Subjects – Influence of Stress and Alcohol in Simulated Traffic Situations
- 2021
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 1:83
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Tidskriftsartikel (refereegranskat)abstract
- This report presents a research study plan on human subjects – the influence of stress and alcohol in simulated traffic situations under an H2020 project named SIMUSAFE. This research study focuses on road-users’, i.e., car drivers, motorcyclists, bicyclists and pedestrians, behaviour in relation to retrospective studies, where interaction between the users are considered. Here, the study includes sample size, inclusion/exclusion criteria, detailed study plan, protocols, potential test scenarios and all related ethical issues. The study plan has been included in a national ethics application and received approval for implementation.
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| 2. |
- Buselli, Irene, et al.
(författare)
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Natural language processing for aviation safety : Extracting knowledge from publicly-available loss of separation reports
- 2022
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; , s. 1-39
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Tidskriftsartikel (refereegranskat)abstract
- Background: The air traffic management (ATM) system has historicallycoped with a global increase in traffic demand ultimately leading toincreased operational complexity.When dealing with the impact of this increasing complexity on systemsafety it is crucial to automatically analyse the losses of separation(LoSs) using tools able to extract meaningful and actionableinformation from safety reports.Current research in this field mainly exploits natural languageprocessing (NLP) to categorise the reports,with the limitations that theconsidered categories need to be manually annotated by experts andthat general taxonomies are seldom exploited.Methods: To address the current gaps,authors propose to performexploratory data analysis on safety reports combining state-of-the-arttechniques like topic modelling and clustering and then to develop analgorithm able to extract the Toolkit for ATM Occurrence Investigation(TOKAI) taxonomy factors from the free-text safety reports based onsyntactic analysis.TOKAI is a tool for investigation developed by EUROCONTROL and itstaxonomy is intended to become a standard and harmonisedapproach to future investigations.Results: Leveraging on the LoS events reported in the publicdatabases of the Comisi n de Estudio y An lisis de Notificaciones deIncidentes de Tr nsito A reo and the United Kingdom AirproxBoard,authors show how their proposal is able to automaticallyextract meaningful and actionable information from safetyreports,other than to classify their content according to the TOKAItaxonomy.The quality of the approach is also indirectly validated by checking theconnection between the identified factors and the main contributor ofthe incidents.Conclusions: Authors' results are a promising first step toward the fullautomation of a general analysis of LoS reports supported by resultson real-world data coming from two different sources.In the future,authors' proposal could be extended to othertaxonomies or tailored to identify factors to be included in the safetytaxonomies.KeywordsATM, Safety, Resilience, Natural Language Processing, Losses ofSeparation, Safety Reports, TOKAI
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| 3. |
- Cheng, Jingmin, et al.
(författare)
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Interspecific competition affects spore germination and gametophore development of mosses
- 2023
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Ingår i: Open Research Europe. - 2732-5121. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- Background: Interactions between moss species in their earliest growth stages have received little attention. To what extent interspecific competition or priority effects influence spore germination, protonemal development and gametophore emergence is unknown. We evaluated such effects in pairwise interaction between six common bryophyte species: Atrichum undulatum, Bryum argenteum, Ceratodon purpureus, Funaria hygrometrica, Hypnum cupressiforme, Leptobryum pyriforme Methods: Interspecific interactions were assessed in vitro. Spores were sterilized and sown on agar plates in three treatments: 1) as single species cultures (controls), 2) as pairwise species cultures inoculated simultaneously, and 3) with a time lag of 20 days between species. Data on the time needed for spore germination, germination rate, the time needed for gametophore differentiation, number of gametophores per germinated spore and average diameter of colonies were collected. We also performed spore germination tests in single-species cultures at the start and end of the study, as well as tests for density-dependency at spore germination and gametophore formation. Results: We observed strong pairwise interactive effects when sowing spores of different species simultaneously or with a delay of 20 days. The results indicate that spore germination is often inhibited by interspecific competition. The first species has an advantage as compared to the later colonizing species, i.e., an apparent priority effect. Interspecific interactions were also evident during gametophore development and included both inhibition and facilitation. Conclusion: We found pronounced differences in the relative performance of species in interaction with other species during spore germination and gametophore formation. Allelopathic effects are the most probable explanation for these observations. Our results under sterile lab conditions are likely to reflect processes that occur in the wild, governing biotic filtering and bryophyte community assembly during primary and secondary colonization.
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| 4. |
- Coombs, H, et al.
(författare)
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Creating personas for exposome research: the experience from the HEAP project
- 2023
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Ingår i: Open research Europe. - : F1000 Research Ltd. - 2732-5121. ; 3, s. 28-
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Tidskriftsartikel (refereegranskat)abstract
- The exposome is a complex scientific field that has enjoyed consistent growth over the last two decades, defined as the composite of every exposure to which an individual is subjected from conception to death. The study of the exposome requires consideration of both the nature of those exposures and their changes over time, and as such necessitates high quality data and software solutions. As the exposome is both a broad and a recent concept, it is challenging to define or to introduce in a structured way. Thus, an approach to assist with clear definitions and a structured framework is needed for the wider scientific and public communication. Results: A set of 14 personas were developed through three focus groups and a series of 14 semi-structured interviews. The focus groups defined the broad themes specific to exposome research, while the sub-themes emerged to saturation via the interviews process. Personas are imaginary individuals that represent segments/groups of real people within a population. Within the context of the HEAP project, the created personas represented both exposome data generators and users. Conclusion: Personas have been implemented successfully in computer science, improving the understanding of human-computer interaction. The creation of personas specific to exposome research adds a useful tool supporting education and outreach activities for a complex scientific field.
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| 5. |
- Ghandour, Salim, et al.
(författare)
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Quasi-static and dynamic mechanical properties of a low-modulus bone cement for spinal applications
- 2023
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Ingår i: Open Research Europe. - : European Commission. - 2732-5121. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- Background:Polymethylmethacrylate (PMMA) bone cement is extensively used in spinal procedures such as vertebroplasty and kyphoplasty, while its use in percutaneous cement discoplasty (PCD) is not yet widely spread. A main issue for both application sites, vertebra and disc, is the mismatch in stiffness between cement and bone, potentially resulting in adjacent vertebral fractures and adjacent segment disease. Tailoring the cement modulus using additives is hence an interesting strategy. However, there is a lack of data on the tensile and tension-compression fatigue properties of these cements, relevant to the newly researched indication of PCD. Method:A commercial PMMA cement (VS) was modified with 12%vol of linoleic acid (VSLA) and tested for quasi-static tensile properties. Additionally, tension-compression fatigue testing with amplitudes ranging from +/-5MPa to +/-7MPa and +/-9MPa was performed, and a Weibull three-parameter curve fit was used to calculate the fatigue parameters. Results:Quasi-static testing revealed a significant reduction in VSLA’s Young’s Modulus (E=581.1±126.4MPa) compared to the original cement (E=1478.1±202.9MPa). Similarly, the ultimate tensile stress decreased from 36.6±1.5MPa to 11.6±0.8MPa. Thus, VSLA offers improved compatibility with trabecular bone properties. Fatigue testing of VSLA revealed that as the stress amplitude increased the Weibull mean number decreased from 3591 to 272 and 91 cycles, respectively. In contrast, the base VS cement reached run-out at the highest stress amplitude. However, the lowest stress amplitude used exceeds the pressures recorded in the disc in vivo, and VSLA displayed a similar fatigue life range to that of the annulus fibrosis tissue.Conclusions:While the relevance of fully reversed tension-compression fatigue testing can be debated for predicting cement performance in certain spinal applications, the results of this study can serve as a benchmark for comparison of low-modulus cements for the spine. Further investigations are necessary to assess the clinical feasibility and effectiveness of these cements.
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| 6. |
- Karimzadeh, Sara, 1983-, et al.
(författare)
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Ethical consumption : why should we understand it as a social practice within a multilevel framework?
- 2022
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Ingår i: Open Research Europe. - : European Commission. - 2732-5121. ; 2:109
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Tidskriftsartikel (refereegranskat)abstract
- This article discusses the importance of a multilevel and intertwined understanding of ethical consumption given its conjunction with other social practices. Although the literature on ethical consumption is vast, the role of sociotechnical regimes including technological and cultural elements, infrastructure, market and regulation has been mainly overlooked in this literature. This may be so because ethical consumption practices that refer to other-oriented consumption practices are mainly considered in the view of the motivations and preferences of individual consumers. Due to the insufficiency of individualistic approaches to explain stimulators and inhibitors of ethical consumption, indicates there might be “various constraints” in society and “competing demands” to hamper consumers from acting ethically. Therefore, to avoid an oversimplified view of ethical consumption, this paper contributes with a theoretical discussion on combining social practice theory (SPT) with a multi-level perspective (MLP). Although the SPT is a very well-structured framework in consumption studies, the necessity of a combined approach concerns the often-insufficient attention paid to structural prerequisites of various consumption forms in social practice theories. By understanding ethical consumption practices according to a multilevel framework, the paper emphasizes the importance of structural factors at macro- and mesolevels. It also contributes attention to how ethical consumption grows due to dialectical processes between levels, showing that niche practices can simultaneously challenge and rely on existing regimes
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| 7. |
- Koivisto, Antti Joonas, et al.
(författare)
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Assessment of exposure determinants and exposure levels by using stationary concentration measurements and a probabilistic near-field/far-field exposure model
- 2021
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation requires the establishment of Conditions of Use (CoU) for all exposure scenarios to ensure good communication of safe working practices. Setting CoU requires the risk assessment of all relevant Contributing Scenarios (CSs) in the exposure scenario. A new CS has to be created whenever an Operational Condition (OC) is changed, resulting in an excessive number of exposure assessments. An efficient solution is to quantify OC concentrations and to identify reasonable worst-case scenarios with probabilistic exposure modeling. Methods: Here, we appoint CoU for powder pouring during the industrial manufacturing of a paint batch by quantifying OC exposure levels and exposure determinants. The quantification was performed by using stationary measurements and a probabilistic Near-Field/Far-Field (NF/FF) exposure model. Work shift and OC concentration levels were quantified for pouring TiO 2 from big bags and small bags, pouring Micro Mica from small bags, and cleaning. The impact of exposure determinants on NF concentration level was quantified by (1) assessing exposure determinants correlation with the NF exposure level and (2) by performing simulations with different OCs. Results: Emission rate, air mixing between NF and FF and local ventilation were the most relevant exposure determinants affecting NF concentrations. Potentially risky OCs were identified by performing Reasonable Worst Case (RWC) simulations and by comparing the exposure 95 th percentile distribution with 10% of the occupational exposure limit value (OELV). The CS was shown safe except in RWC scenario (ventilation rate from 0.4 to 1.6 1/h, 100 m 3 room, no local ventilation, and NF ventilation of 1.6 m 3/min). Conclusions: The CoU assessment was considered to comply with European Chemicals Agency (ECHA) legislation and EN 689 exposure assessment strategy for testing compliance with OEL values. One RWC scenario would require measurements since the exposure level was 12.5% of the OELV.
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| 8. |
- Lindström Sol, Sofia, 1981-, et al.
(författare)
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Mapping research on the social impact of the arts: what characterises the field?
- 2022
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 1:124
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Tidskriftsartikel (refereegranskat)abstract
- This article explores the broad and undefined research field of the social impact of the arts. The effects of art and culture are often used as justification for public funding, but the research on these interventions and their effects is unclear. Using a co-word analysis of over 10,000 articles published between 1990 and 2020, we examined the characteristics of the field as we have operationalised it through our searches. We found that since 2015 this research field has expanded and consists of different epistemologies and methodologies, summarised in largely overlapping subfields belonging to the social sciences, humanities, arts education, and arts and health/therapy. In formal or informal learning settings, studies of theatre/drama as an intervention to enhance skills, well-being, or knowledge among children are most common in our corpus. A study of the research front through the bibliographic coupling of the most cited articles in the corpus confirmed the co-word analysis and revealed new themes that together form the ground for insight into research on the social impact of the arts. This article can therefore inform discussions on the social value of culture and the arts.
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| 9. |
- Lloret, Elena, et al.
(författare)
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Multi3Generation : Multitask, Multilingual, and Multimodal Language Generation
- 2023
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Ingår i: Open Research Europe. - : European Commission. - 2732-5121. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this article is to highlight the critical importance of language generation today. In particular, language generation is explored from the following three aspects: multi-modality, multilinguality, and multitask, which all of them play crucial role for Natural Language Generation (NLG) community. We present the activities conducted within the Multi3Generation COST Action (CA18231), as well as current trends and future perspectives for multitask, multilingual and multimodal language generation.
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| 10. |
- Melin, Martin, Universitetslektor, 1977-, et al.
(författare)
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Facilitating transformative innovations in sustainability education
- 2022
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Educational strategies globally are changing from an authoritative, top-down model to one focused on greater student and stakeholder participation in planning and implementation of research and educational activities. In addition to emphasis on student-centered education, strategies currently evolve to encompass learning organizations and multistakeholder learning networks. These are essential to address the complexity and scope of tomorrow’s challenges, involving issues that could be called ’wicked problems’ not easily addressed by single disciplines nor resulting in solutions that please all the players. In this study we describe how a transformative innovation – the NEXTFOOD educational approach – may contribute substantially to a transition of agricultural and food education and how it can be developed and diffused within and between teaching institutions. The method was action research informed by several workshops organized at annual consortium conferences during the first three years of the project. The findings show that a successful transformation involves learning both within and across innovation projects repeated at various organisations in a network. The action research model presented in this paper may be useful as an instrument to support the facilitation of transformative innovations. The transition process resulted in substantial changes in mindset, educational practices and organisational structures at the teaching institutions. However, scaling-up promising educational initiatives may encounter several barriers that need to be overcome at individual, group and institutional levels, and we provide insight on how this can be accomplished in a multi-national consortium of universities.
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| 11. |
- Melin, Martin
(författare)
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Facilitating transformative innovations in sustainability education [version 2; peer review: 2 approved]
- 2022
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Educational strategies globally are changing from an authoritative, top-down model to one focused on greater student and stakeholder participation in planning and implementation of research and educational activities. In addition to emphasis on student-centered education, strategies currently evolve to encompass learning organizations and multistakeholder learning networks. These are essential to address the complexity and scope of tomorrow’s challenges, involving issues that could be called ’wicked problems’ not easily addressed by single disciplines nor resulting in solutions that please all the players. In this study we describe how a transformative innovation – the NEXTFOOD educational approach – may contribute substantially to a transition of agricultural and food education and how it can be developed and diffused within and between teaching institutions. The method was action research informed by several workshops organized at annual consortium conferences during the first three years of the project. The findings show that a successful transformation involves learning both within and across innovation projects repeated at various organisations in a network. The action research model presented in this paper may be useful as an instrument to support the facilitation of transformative innovations. The transition process resulted in substantial changes in mindset, educational practices and organisational structures at the teaching institutions. However, scaling-up promising educational initiatives may encounter several barriers that need to be overcome at individual, group and institutional levels, and we provide insight on how this can be accomplished in a multi-national consortium of universities.
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| 12. |
- Melin, Martin, Universitetslektor, 1977-, et al.
(författare)
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Network learning and transitional change in a global project for transforming sustainability education
- 2022
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Educational strategies globally are changing from an authoritative, top-down model to one focused on greater student and stakeholder participation in planning and implementation of research and educational activities. In addition to emphasis on student-centered education, strategies currently evolve to encompass learning organizations and multistakeholder learning networks. These are essential to address the complexity and scope of tomorrow’s challenges, involving issues that could be called ’wicked problems’ not easily addressed by single disciplines nor resulting in solutions that please all the players. In this study we describe how a transformative innovation – the NEXTFOOD educational approach – may contribute substantially to a transition of agricultural and food education and how it can be developed and diffused within and between teaching institutions. The method was action research informed by several workshops organized at annual consortium conferences during the first three years of the project. The findings show that a successful transformation involves learning both within and across innovation projects repeated at various organisations in a network. The action research model presented in this paper may be useful as an instrument to support the facilitation of transformative innovations. The transition process resulted in substantial changes in mindset, educational practices and organisational structures at the teaching institutions. However, scaling-up promising educational initiatives may encounter several barriers that need to be overcome at individual, group and institutional levels, and we provide insight on how this can be accomplished in a multi-national consortium of universities.
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| 13. |
- Meyer, E., et al.
(författare)
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The state of the art in beyond 5G distributed massive multiple-input multiple-output communication system solutions
- 2022
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 2
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Forskningsöversikt (refereegranskat)abstract
- Beyond fifth generation (5G) communication systems aim towards data rates in the tera bits per second range, with improved and flexible coverage options, introducing many new technological challenges in the fields of network architecture, signal pro- cessing, and radio frequency front-ends. One option is to move towards cell-free, or distributed massive Multiple-Input Multiple-Output (MIMO) network architectures and highly integrated front-end solutions. This paper presents an outlook on be- yond 5G distributed massive MIMO communication systems, the signal processing, characterisation and simulation challenges, and an overview of the state of the art in millimetre wave antennas and electronics.
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| 14. |
- Resseguier, Anaïs, et al.
(författare)
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Ethics as attention to context: recommendations for the ethics of artificial intelligence
- 2021
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 1:27
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This article shows that current ethics guidance documents andinitiatives for artificial intelligence (AI) tend to be dominated by aprincipled approach to ethics. Although this brings value to the field, italso entails some risks, especially in relation to the abstraction of thisform of ethics that makes it poorly equipped to engage with andaddress deep socio-political issues and the material impacts of AI. Thisis particularly problematic considering the risk for AI to furtherentrench already existing social inequalities and injustices andcontribute to environmental damage. To respond to this challengeposed by AI ethics today, this article proposes to complement theexisting principled approach with an approach to ethics as attentionto context and relations. It does so by drawing from alternative ethicaltheories to the dominant principled one, especially the ethics of careor other feminist approaches to ethics. Related to this, it encouragesthe inclusion of social sciences and humanities in the development,deployment and use of AI, as well as in AI ethics discussions andinitiatives. This article presents this proposal for an ethics as attentionto context and formulates a series of practical recommendations toimplement this proposal concretely
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| 15. |
- Smrčka, Aleš, et al.
(författare)
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Towards an extensive set of criteria for safety and cyber-security evaluation of cyber-physical systems
- 2023
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Ingår i: Open Research Europe. - 2732-5121. - 9781665485555 ; 3
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Tidskriftsartikel (refereegranskat)abstract
- Verification and validation (V&V) are complex processes combining different approaches and incorporating many different methods including many activities. System engineers regularly face the question if their V&V activities lead to better products, and having appropriate criteria at hand for evaluation of safety and cybersecurity of the systems would help to answer such a question. Additionally, when there is a demand to improve the quality of an already managed V&V process, there is a struggle over what criteria to use in order to measure the improvement. This paper presents an extensive set of criteria suitable for safety and cybersecurity evaluation of cyberphysical systems. The evaluation criteria are agreed upon by 60 researchers from 32 academic and industrial organizations jointly working in a large-scale European research project on 13 real-world use cases from the domains of automotive, railway, aerospace, agriculture, healthcare, and industrial robotics.
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| 16. |
- Sundaramurthi, Husvinee, et al.
(författare)
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Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes
- 2023
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 13:3
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Tidskriftsartikel (refereegranskat)abstract
- Background: Uveal melanoma is a poor prognosis cancer. Ergolide, a sesquiterpene lactone isolated from Inula Brittanica, exerts anti-cancer properties. The objective of this study was to 1) evaluate whether ergolide reduced metastatic uveal melanoma (MUM) cell survival/viability in vitro and in vivo; and 2) to understand the molecular mechanism of ergolide action. Methods: Ergolide bioactivity was screened via long-term proliferation assay in UM/MUM cells and in zebrafish MUM xenograft models. Mass spectrometry profiled proteins modulated by ergolide within whole cell or extracellular vesicle (EVs) lysates of the OMM2.5 MUM cell line. Protein expression was analyzed by immunoblots and correlation analyses to UM patient survival used The Cancer Genome Atlas (TCGA) data. Results: Ergolide treatment resulted in significant, dose-dependent reductions (48.5 to 99.9%; p<0.0001) in OMM2.5 cell survival in vitro and of normalized primary zebrafish xenograft fluorescence (56%; p<0.0001) in vivo, compared to vehicle controls. Proteome-profiling of ergolide-treated OMM2.5 cells, identified 5023 proteins, with 52 and 55 proteins significantly altered at 4 and 24 hours, respectively (p<0.05; fold-change >1.2). Immunoblotting of heme oxygenase 1 (HMOX1) and growth/differentiation factor 15 (GDF15) corroborated the proteomic data. Additional proteomics of EVs isolated from OMM2.5 cells treated with ergolide, detected 2931 proteins. There was a large overlap with EV proteins annotated within the Vesiclepedia compendium. Within the differentially expressed proteins, the proteasomal pathway was primarily altered. Interestingly, BRCA2 and CDKN1A Interacting Protein (BCCIP) and Chitinase Domain Containing 1 (CHID1), were the only proteins significantly differentially expressed by ergolide in both the OMM2.5 cellular and EV isolates and they displayed inverse differential expression in the cells versus the EVs. Conclusions: Ergolide is a novel, promising anti-proliferative agent for UM/MUM. Proteomic profiling of OMM2.5 cellular/EV lysates identified candidate pathways elucidating the action of ergolide and putative biomarkers of UM, that require further examination. Copyright: © 2023 Sundaramurthi H et al.
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| 17. |
- Urinboyev, Rustamjon, et al.
(författare)
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Ethnic and religious identities in Russian penal institutions: A case study of Uzbek Transnational Muslim prisoners
- 2024
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Ingår i: Open Research Europe. - 2732-5121. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- Russia has become one of the main migration hubs worldwide following the collapse of the Soviet Union. The vast majority of migrant workers travel to Russia from three Central Asian countries. However, Russian immigration laws and policies are ambiguous and highly punitive. The result is that many migrants resort to undocumented status working in the shadow economy, which places them in a disadvantaged and precarious position. In this position they are vulnerable to becoming targets of the Russian criminal justice system as they take to crime to overcome economic uncertainty, become embroiled in interpersonal conflicts ending in violence, or fall victim to fabricated criminal charges initiated by Russian police officers under pressure to produce their monthly quota of arrests. The impact on Russian penal institutions is that they have become ethnically, culturally, and religiously diverse sites as a consequence of the incarceration of growing numbers of transnational prisoners. Using person-to-person interviews conducted in Uzbekistan with men and women who served sentences in Russian penal institutions during the past two decades, we show in this article how the large-scale migratory processes have transformed Russian prisons into sites of ethnic and religious plurality, in which formal rules and informal sub-cultures - the colony regime, so-called thieves' law (vorovskoy zakon), ethnic solidarity norms, and Sharia law - coexist and clash in new ways compared with the status quo ante. Thus, we argue there is a need to revise the prevailing understanding about the power dynamics in Russian penal institutions. Our findings undermine the prison service's insistence of the ethnic and ethno-religious neutrality and cosmopolitanism of Russian penal space, which is presented as a latter-day manifestation of the Soviet-era 'friendship of nations' policy. Russian prisons today must be understood as sites of ethnic and religious pluralism.
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| 18. |
- Usher, William, Dr, 1982-, et al.
(författare)
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Global sensitivity analysis to enhance the transparency and rigour of energy system optimisation modelling
- 2023
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- Background: Energy system optimisation models (ESOMs) are commonly used to support long-term planning at national, regional, or continental scales. The importance of recognising uncertainty in energy system modelling is regularly commented on but there is little practical guidance on how to best incorporate existing techniques, such as global sensitivity analysis, despite some good applications in the literature.Methods: In this paper, we provide comprehensive guidelines for conducting a global sensitivity analysis of an ESOM, aiming to remove barriers to adopting this approach. With a pedagogical intent, we begin by exploring why you should conduct a global sensitivity analysis. We then describe how to implement a global sensitivity analysis using the Morris method in an ESOM using a sequence of simple illustrative models built using the Open Source energy Modelling System (OSeMOSYS) framework, followed by a realistic example.Results: Results show that the global sensitivity analysis identifies influential parameters that drive results in the simple and realistic models, and identifies uninfluential parameters which can be ignored or fixed. We show that global sensitivity analysis can be applied to ESOMs with relative ease using freely available open-source tools. The results replicate the findings of best-practice studies from the field demonstrating the importance of including all parameters in the analysis and avoiding a narrow focus on particular parameters such as technology costs.Conclusions: The results highlight the benefits of performing a global sensitivity analysis for the design of energy system optimisation scenarios. We discuss how the results can be interpreted and used to enhance the transparency and rigour of energy system modelling studies.
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| 19. |
- Wang, J, et al.
(författare)
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A pilot study of risk-stratified cervical cancer screening
- 2021
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Ingår i: Open research Europe. - : F1000 Research Ltd. - 2732-5121. ; 1, s. 84-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Cervical screening programs target entire populations, although it is well established that cervical cancer risks can vary >100-fold based, in particular, on the woman’s screening history. Since cervical screening switched to Human Papillomavirus (HPV) testing as the primary screening method, the risk differences are even larger as different HPV types may vary in associated cancer risk by 100 times. Furthermore, HPV infections with the most oncogenic types are declining dramatically because of HPV vaccination programs. Tailoring screening intensity based on the known cancer risk of the individual (risk-stratified screening) therefore has great potential to increase both the sensitivity and specificity. Within Horizon 2020 a major project for Risk-stratified Screening for Cervical Cancer (RISCC) has therefore been launched. We performed a pilot study of risk-stratified screening to evaluate feasibility and acceptability of offering vaginal HPV self-sampling tests to women with a higher risk of cervical cancer. Methods: We identified resident women who had had either i) atypical glandular cells in screening tests during the past six years (risk >150/100,000 woman-years) or ii) abnormal screening findings above the age of 50, but without sufficient follow-up (risk >65/100,000). The women were invited, either by short message service (SMS) or physical letters, to order an HPV self-sampling kit via the study web-platform. The returned self-collected samples were tested for HPV. If positive, women were invited for clinical follow-up. Results: Among 920 targeted women, 191 (21%) placed an order and 163 (18%) returned a self-collected sample. Among all tested samples, 19 (12%) were positive for hrHPV and 18 of these women attended clinical follow-up. Conclusions: SMS invitations to high-risk women complemented with physical letters are feasible and result in substantial requests for kits and submission of samples. Future work will focus on improving the efficiency of the procedure and further increasing attendance.
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| 20. |
- Westbury, M.V., et al.
(författare)
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A genomic exploration of the early evolution of extant cats and their sabre-toothed relatives
- 2021
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 1:25
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Tidskriftsartikel (refereegranskat)abstract
- Background: The evolutionary relationships of Felidae during their Early–Middle Miocene radiation is contentious. Although the early common ancestors have been subsumed under the grade-group Pseudaelurus, this group is thought to be paraphyletic, including the early ancestors of both modern cats and extinct sabretooths. Methods: Here, we sequenced a draft nuclear genome of Smilodon populator, dated to 13,182 ± 90 cal BP, making this the oldest palaeogenome from South America to date, a region known to be problematic for ancient DNA preservation. We analysed this genome, together with genomes from other extinct and extant cats to investigate their phylogenetic relationships. Results: We confirm a deep divergence (~20.65 Ma) within sabre-toothed cats. Through the analysis of both simulated and empirical data, we show a lack of gene flow between Smilodon and contemporary Felidae. Conclusions: Given that some species traditionally assigned to Pseudaelurus originated in the Early Miocene ~20 Ma, this indicates that some species of Pseudaelurus may be younger than the lineages they purportedly gave rise to, further supporting the hypothesis that Pseudaelurus was paraphyletic.
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| 21. |
|
|
