| 1. |
- Anrup, Roland, et al.
(författare)
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Centrala universitetsvärden hotas av bolagiseringsidén
- 2013
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Ingår i: Dagens nyheter. - 1101-2447.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Högskolestiftelser. Förslaget att driva svenska universitet i stiftelseform öppnar för bolagisering. Men det är ingen riktig utredning, utan en politisk pamflett utan eftertanke. Privatisering av universitet hotar både oberoendet, forskningskvaliteten och samhällsnyttan, skriver 36 forskare vid svenska högskolor och universitet.
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| 2. |
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| 3. |
- Malmgren, Linnea, et al.
(författare)
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The complexity of kidney disease and diagnosing it - Cystatin C, selective glomerular hypofiltration syndromes and proteome regulation.
- 2023
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Ingår i: Journal of Internal Medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 293:3, s. 293-308
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Tidskriftsartikel (refereegranskat)abstract
- Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous GFR-markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has resulted in new knowledge concerning the pathophysiology of kidney disorders by identification of a new set of kidney disorders, selective glomerular hypofiltration syndromes. These syndromes, connected to strong increases in mortality and morbidity, are characterised by a selective reduction in the glomerular filtration of 5-30 kDa molecules, such as cystatin C, compared to the filtration of small molecules < 1kDa dominating the glomerular filtrate e.g., water, urea, creatinine. At least two types of such disorders, shrunken or elongated pore syndrome, are possible according to the pore model for glomerular filtration. Selective glomerular hypofiltration syndromes are prevalent in investigated populations, and patients with these syndromes often display normal measured GFR or creatinine-based GFR-estimates. The syndromes are characterised by proteomic changes promoting the development of atherosclerosis, indicating antibodies and specific receptor-blocking substances as possible new treatment modalities. Presently, the KDIGO guidelines for diagnosing kidney disorders do not recommend cystatin C as a general marker of kidney function and will therefore not allow the identification of a considerable number of patients with selective glomerular hypofiltration syndromes. Furthermore, as cystatin C is uninfluenced by muscle mass, diet or variations in tubular secretion and cystatin C-based GFR-estimation equations do not require controversial race or sex terms, it is obvious that cystatin C should be a part of future KDIGO guidelines.
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| 4. |
- Stenseke, Marie, et al.
(författare)
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Kris i naturen – vår existens har blivit sårbar
- 2019
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Ingår i: Svenska Dagbladet, Stockholm. - 1101-2412.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Fler arter än någonsin i mänsklighetens historia hotas av utrotning och den biologiska mångfalden lokalt har förändrats kraftigt i en stor del av världens ekosystem. Grundläggande förändringar behövs både i samhället och för individer, för att bromsa den negativa trenden, skriver en rad debattörer.
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| 5. |
- Ahlbäck Öberg, Shirin, Professor, 1964-, et al.
(författare)
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Avkollegialiseringen av svenska lärosäten : En analys av statliga universitet och högskolor
- 2022
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Ingår i: Statsvetenskaplig Tidskrift. - Lund : Fahlbeckska stiftelsen. - 0039-0747. ; 124:1, s. 157-209
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Tidskriftsartikel (refereegranskat)abstract
- The Decollegialization of Higher Education Institutions – an Examination of Public Sector Higher Education Institutions in SwedenThis article surveys current management ideals of higher education institutions (HEIs), and our analytical focus is on the balance between line management and fac-ulty self-governance. We present an empirical study of evolving governance struc-tures including all 31 public sector HEIs in Sweden. The point of departure is the Autonomy Reform of 2011, which resulted in a deregulation of the Higher Education Act and a loss of constitutional support for collegial bodies. To assess the conse-quences of the reform, we have examined collegial bodies and academic leadership posts before and after the reform. Our findings show escalating line management in the appointment of academic leaders, a diluted role for collegial expertise, and a loss of decision-making authority for collegial bodies. Hence, the decollegialization of HEIs in Sweden. Our study contributes to the existing literature with an unusually comprehensive analysis of the consequences of new managerial ideals at the local institutional level.
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| 6. |
- Ahlbäck Öberg, Shirin, Professor, 1964-, et al.
(författare)
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Svenska lärosäten : organisering, finansiering, positionering
- 2022
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Ingår i: Statsvetenskaplig Tidskrift. - Lund : Fahlbeckska stiftelsen. - 0039-0747. ; 124:1, s. 5-18
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Tidskriftsartikel (refereegranskat)abstract
- Våren 2021 tog riksdagen ställning till den elfte forskningspolitiska propositionen i ordningen, Forskning, frihet, framtid – kunskap och innovation för Sverige (prop. 2020/21:60). Bara genom att studera forskningspropositionernas rubriker kan man enkelt avläsa vilka primära mål sittande regering har med sin forskningspolitik. Förra gången det begav sig stod samverkan högst på agendan. På propositionens 167 sidor nämndes ”samverkan” hela 224 gånger, medan en konkurrent som ”frihet” i stort lyste med sin frånvaro och enbart nämndes sex gånger (prop. 2016/17:50). I den nu aktuella forskningspropositionen har emellertid ”frihet” getts en mer framträdande roll än någonsin tidigare – vilket även framgår av rubriken – och omnämns hela 141 gånger (”samverkan” är dock mer än dubbelt så vanligt) (prop. 2020/21:60). Skälet till att frihetsfrågan fått en så framträdande roll denna gång är förstås de förslag om att föra in akademisk frihet i högskolelagen som Styr- och resursutredningen presenterat i sitt betänkande (”Struten”, se SOU 2019:6). Men hur ska vi förstå denna politiska strävan efter att stärka den akademiska friheten? I detta specialnummer tar vi ett bredare grepp om hur högskolepolitiken utvecklats över tid, och frågar oss vad som utmärker denna frihet. Vem är det som ska ges frihet? Hur ser balansen mellan formell och reell frihet ut? Vad utmärker dem som skänks frihet – oftast lärosätena – och hur skiljer de sig åt?
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| 7. |
- Ahlbäck Öberg, Shirin, Professor, 1964-, et al.
(författare)
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The Decollegialization of Higher Education Institutions in Sweden
- 2023
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Ingår i: Nordic Journal of Studies in Educational Policy. - : Routledge. - 2002-0317. ; 9:2, s. 126-143
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Tidskriftsartikel (refereegranskat)abstract
- This article surveys current management ideals of higher education institutions, and our analytical focus is on the balance between line management and faculty self-governance. It presents an empirical study of evolving governance structures including all 31 public sector higher education institutions in Sweden. The point of departure is the Autonomy Reform of 2011, which resulted in a deregulation of the Higher Education Act, and a loss of constitutional support for collegial bodies. To assess the consequences of the reform, we have examined collegial bodies and academic leadership posts before the reform (2010) and after (2020). Our findings show escalating line management in the appointment of academic leaders, a diluted role for collegial expertise, and a loss of decision-making authority for collegial bodies. What we observe is the decollegialization of higher education institutions. Our study contributes to the existing literature with an unusually comprehensive and fine-grained analysis of the consequences of new managerial ideals at the local institutional level.
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| 8. |
- Ahlbäck Öberg, Shirin, Professor, 1964-, et al.
(författare)
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Ökad kontroll och ökad byråkratisering : En kartläggning av statens styrning av universitet och högskolor
- 2024
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I denna rapport kartlägger vi den ökade kontrollen och ökade byråkratiseringen av framförallt de statliga lärosätena i Sverige under åren 1993–2023. Vi har analyserat utvecklingen av högskoleförfattningarna, regleringsbreven riktade mot universitet och högskolor (gemensamma och individuella) och relevanta sektorsmyndigheters, samt de generella författningar som träffar lärosätena antingen i egenskap av statliga myndigheter eller genom en mer generell räckvidd även bortom myndigheterna.Vår undersökning visar att det framförallt är generell lagstiftning kopplad till olika politiska målsättningar – tillsammans med staplandet av politiska mål i högskoleförfattningarna – som sammantaget resulterar i en orimlig administrativ börda för lärosätena. Den målträngsel som vi åskådliggör vittnar om en oförmåga hos lagstiftaren att prioritera. Även om en del av den generella lagstiftningen i någon mån varit aktuell redan vid undersökningsperiodens början så har den politiska ambitionsnivån på de flesta områden höjts avsevärt under senare år. Ytterst sällan åtföljs de stegrade ambitionerna av tillförda resurser, utan de nya eller ”förtydligade” uppgifterna ska istället i nästan samtliga fall utföras inom befintliga ekonomiska ramar. Vi menar att det är anmärkningsvärt att fler och fler byråkratidrivande regelverk införs utan att man vid något tillfälle diskuterar hur detta kommer att påverka lärosätenas möjligheter att bedriva kärnverksamheten.
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| 9. |
- Anderson, Helén, et al.
(författare)
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Are Mergers or Acquisitions expected to affect customer and supplier relationships? : An Analysis of Decisions Taken by a Competition Authority
- 2003
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Konferensbidrag (refereegranskat)abstract
- Studies concerning corporate mergers and acquisitions are mainly focused on the merging companies. Recently though, there has been an increased interest concerning connected companies, e.g. those firms having customer, supplier or other business relationships with participants in a merger or acquisition. In many countries, there is a legal prerequisite to report intended business concentration to the national competition authority for investigation. This paper investigates decisions made by a competition authority and in addition looks at studies where connected companies are mentioned by the authorities in such decisions. In very few of the investigated decisions, 2.4%, is a third party identified. Our conclusion is that customers and suppliers, if at all effected, are seen as reactive rather than active partners in a concentration. And, the concept supplier or customer relationship is not used.
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| 11. |
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| 12. |
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| 13. |
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| 15. |
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| 16. |
- Anderson, Helén, et al.
(författare)
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Do Competition Authorities Consider Business Relationships?
- 2012
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Ingår i: Journal of Business-to-Business Marketing. - : Taylor and Francis (Routledge). - 1051-712X .- 1547-0628. ; 19:1, s. 67-92
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Companies engage in business relationships for a variety of reasons, including specialization, product development, and building competitive networks. Research has demonstrated that mergers and acquisitions (Mandamp;As) may challenge ongoing business relationships. The purpose of this article is to investigate whether and how competition authorities consider business relationships when evaluating Mandamp;As. less thanbrgreater than less thanbrgreater thanMethodology: The article uses the documentation from 450 Mandamp;As reported to the Swedish competition authority to capture the way in which an authority evaluates Mandamp;As. The Swedish competition authority evaluation corresponds to other national and international evaluation procedures. less thanbrgreater than less thanbrgreater thanFindings: The findings indicate that the competition authorities neglect an important aspect of business life, namely companies forming business relationships. The competition authorities evaluate Mandamp;As on the basis of risk for price increases, and consequently disregard such issues as heterogeneity in demand and offerings, and values built into existing business relationships. less thanbrgreater than less thanbrgreater thanOriginality/Value/Contribution: The article contributes to research on business relationships through exploring how a public authority deals with such relationships. It also contributes to research on mergers and acquisitions through examining how these activities are evaluated by competition authorities. Furthermore, the article contributes to competition research by reflecting on competition law concerning Mandamp;A regulations in relation to business relationships.
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| 17. |
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| 18. |
- Anderson, Helén, 1954-, et al.
(författare)
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The stake of customers and suppliers in mergers and acquisition
- 2016
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Konferensbidrag (refereegranskat)abstract
- No business day ends without news on a merger or an acquisition and most managers have experience of acquisitions and/or mergers. Mergers and acquisitions (M&A), that is, the acquisition of (the majority of) the shares in a target company or the legal unification of two organizations into one, are recurrent phenomena in business life (Cartwright and Schoenberg, 2006; Meglio and Risberg, 2010) appearing in waves (Martynova and Renneboog 2008; Shleifer and Vishny 1991). M&A not only result in changed shareholder value, but also in changed industry structures, reconsidered competitive landscapes, and form new key players in markets (Chandler, 1962; Cox, 2006; Finkelstein, 1997).Stakeholder research (e.g., Parmar, Freeman, Harrison, Wicks, Prnell and de Colle, 2010; Rowley, 1997) emphasizes the multi-actor, multi-interest perspective to strategic decisions. A value chain perspective on firms suggests customers and suppliers as important stakeholders of firms (e. g., Normann and Ramirez, 1993) and indicates that customers and suppliers may actually act vis-à-vis an M&A. But the picture of customers and suppliers as tradable assets or potential beneficiaries from the acquirer’s point of view seems to dominate. In this paper we particularly address the stake at stake for customers and suppliers in M&A. The following questions are asked: To what extent are customers and suppliers acknowledged in the M&A literature? How are customer and supplier stakes in M&A described?
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| 19. |
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| 20. |
- Anderson, Helén, et al.
(författare)
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The Stake of Customers and Suppliers in Mergers and Acquisitions
- 2016
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Ingår i: SMS 36th Annual Conference.
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Konferensbidrag (refereegranskat)abstract
- For a firm, customers and suppliers are important stakeholders in their business activities, including such strategic activities as mergers and acquisitions. But how has this been depicted in previous research? In this paper we review articles on mergers and acquisitions to find out in what way customers and suppliers are recognized in the research on mergers and acquisitions. The paper is a review of 1,632 articles. The analysis proposes six categories: customers and suppliers in vertical integration; customers as an aggregated market; customers and suppliers as resources; customers (and suppliers) being affected by changed market conditions; the merger or acquisition following from or leading to power imbalances in relationships to customers/suppliers; and customers and suppliers as actors or reactors.
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| 21. |
- Andersson, Per-Johan, et al.
(författare)
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Power mapping and noise reduction for financial correlations
- 2005
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Ingår i: Acta Physica Polonica, Series B. - 0587-4254. ; 36:9, s. 2611-2619
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Konferensbidrag (refereegranskat)abstract
- The spectral properties of financial correlation matrices can show features known from completely random matrices. A major reason is noise originating from the finite lengths of the financial time series used to compute the correlation matrix elements. In recent years, various methods have been proposed to reduce this noise, i.e. to clean the correlation matrices. This is of direct practical relevance for risk management in portfolio optimization. In this contribution, we discuss in detail the power mapping, a new shrinkage method. We show that the relevant parameter is, to a certain extent, self-determined. Due to the "chirality" and the normalization of the correlation matrix, the optimal shrinkage parameter is fixed. We apply the power mapping and the well-known filtering method, to market data and compare them by optimizing stock portfolios. We address the rle of constraints by excluding short selling in the optimization.
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| 22. |
- Aramo-Immonen, Heli, 1964-, et al.
(författare)
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Charting the reach and contribution of IMP literature in other disciplines : A bibliometric analysis
- 2020
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Ingår i: Industrial Marketing Management. - : Elsevier. - 0019-8501 .- 1873-2062. ; 87, s. 47-62
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Tidskriftsartikel (refereegranskat)abstract
- The acknowledgement of a research tradition by other disciplines shows its contribution to the development of the broader body of scientific knowledge. This paper investigates the contribution of IMP (Industrial Marketing and Purchasing) research to broader research disciplines by analyzing how researchers within and beyond IMP have cited core IMP articles. First, through quantitative bibliometric analysis, the paper identifies the diffusion to other research disciplines. Thereafter, through qualitative analysis, the impact of the IMP perspective is captured to understand how strong these imprints are. The analyses show that IMP research has been noticed among a range of adjacent research disciplines. However, the use of IMP references has generally been rudimentary, and without a deeper understanding of the IMP ontology, meaning that IMP still has some “weak ties” to the other disciplines. Establishing IMP's contribution through enduring imprints would need further engagement with researchers from other research disciplines and publications in top journals. The paper contributes empirically with how the IMP perspective has spread beyond the IMP Group and theoretically by adding insight into how research ideas travel and transform to other disciplines.
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| 23. |
- Aramo-Immonen, Heli, 1964-, et al.
(författare)
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Clustering the IMP thought : Searching roots and diversities in IMP research
- 2018
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Ingår i: 34th Annual Industrial Marketing & Purchasing Conference KEDGE Business School, Marseille, France, 4-7 September 2018.
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Konferensbidrag (refereegranskat)abstract
- IMP research is often treated as an empirical perspective describing complexities of repeated business-to-business exchanges and their embeddedness. While building on some common understandings and concepts, this paper asks: How homogeneous is the IMP research? This paper uses cluster analysis to capture the roots and various sub-groups of IMP research as means to depict the question of homogeneity (i.e. a core focus in the research) or heterogeneity (i.e. using references from other fields or specific to sub-fields) of the IMP thought. In this scientific work in progress paper we introduce how we design to use bibliographical methods in order to harvest data from an extensive amount of IMP-related articles written from the 1970’s onwards. In this first attempt to reveal IMP we used overall 294 articles yielded to 10,615 co-citation relationships. A threshold of minimum number of citations of a cited reference was set to five (5) to capture such references that have been cited in multiple publications. We introduce visual mapping of defined subject area clusters and as an example we describe shortly clusters. Perhaps not surprisingly our findings suggest that IMP research is not so homogenous, with at least four clear clusters of IMP-research each utilizing different key referenfernces.
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| 24. |
- Arlinger, Stig, 1939-, et al.
(författare)
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Clinical trial of a digital hearing aid
- 1998
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Ingår i: Scandinavian Audiology. - : Taylor & Francis. - 0105-0397 .- 1940-2872. ; 27:1, s. 51-61
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Tidskriftsartikel (refereegranskat)abstract
- A clinical trial of Oticon DigiFocus hearing aid was performed. The test aid was evaluated on 33 subjects with several years' experience as users of modern analog hearing aids. These aids were used as reference for the 1-month-long trial. The Abbreviated Profile of Hearing Aid Benefit (APHAB) showed a mean difference in benefit with superior ratings for the test aid concerning ease of communication, speech in reverberation and speech in background noise. The subjects' own aids were rated somewhat better concerning aversiveness of sounds, but this difference was not statistically significant. The Gothenburg Profile showed a statistically significant difference between the test aid and the reference aids in favour of the test aid. The difference was not most evident with regard to speech communication and the effects of hearing loss on social interactions. Sound quality ratings concerning clearness were significantly higher for the test aid. Speech recognition thresholds in noise were on average 0.7 dB better for the test aids when tested at speech levels 60 and 75 dB. The difference was statistically significant only at 75 dB. There was significant interaction between general preference and hearing aid type, indicating that overall sound quality was an important factor affecting the general preference for either the test aid or the reference aid. Twenty-three subjects generally preferred the test aid, six preferred their own aid and four stated no difference.
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| 25. |
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ArtMonitor
- 2007
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Ingår i: ArtMonitor. - 1653-9958. ; :1
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Annan publikation (övrigt vetenskapligt/konstnärligt)
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| 26. |
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| 27. |
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| 28. |
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| 29. |
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| 30. |
- Berg, Kristina, et al.
(författare)
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Den goda resan : ett projekt som ska ge nya ideer och perspektiv på utveckling av turistmåltider
- 2000
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Den populärvetenskapliga publikationen "Den goda resan" handlar om turistmåltider i Sveriges inland. Skriften syftar till att ge nya idéer och perspektiv till den som vill utveckla sina turistmåltider och turistverksamheter. I boken förs en diskussion om turistmåltiden som fenomen och olika sätt att leverera måltider beroende på önskemål och situation. Ett historiskt och ett nutida perspektiv på hur mat och resande förhållit och förhåller sig till varandra är ett matnyttigt kapitel. Begrepp som lokala råvaror, regional identitet och balansen mellan det bekanta och det obekanta i turistmåltiden ges stort utrymme. Skriften avslutas med två exempel på hur man kan gå till väga när turistmåltider skapas. Det ena exemplet handlar om hur ett restaurangföretag kan utforma verksamheten, och det andra handlar om hur en turistföretagare kan skapa turistmåltider i nära relation till utomhusaktiviteter. Framför allt fokuseras turistföretagarnas syn på sin verksamhet och vilka problem de får brottas med. Författarna har rest från Gällivare till Hällefors vid olika tillfällen och studerat det måltidsutbud som turisterna idag har tillgång till. De har under sina resor också intervjuat producenter av turistmåltider, från dem som har idéer och handlingskraft att utveckla måltider till dem som inte vet vad de kan göra för att konstruera minnesvärda måltider för turister.
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| 31. |
- Berg, Kristina, et al.
(författare)
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Den goda resan : Turistmåltider i Sverige
- 2001
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rapporten utgår från kopplingen mellan turism och måltid. Turism och måltider är breda begrepp som kan analyseras från många olika perspektiv. I detta arbete har måltiden studerats med kunskaper från etnologi, retorik, företagsekonomi och måltidskunskap. Begreppet turistmåltider lanseras och diskuteras utifrån dessa discipliner. Mat och måltider har en betydelse för oss när vi är hemma och när vi reser. Maten är en central del av vårt kulturella sammanhang, vad och hur vi äter är ett tydligt uttrycksmedel för vilka vi är. Samtidigt som vi håller fast vid vissa mattraditioner präglas också våra matvanor av en stor föränderlighet. Turistmåltider kan därför visa en kulturs traditioner men samtiden och de lokala livsmedlens globala motsvarighet kan också vara attraktiva för dagens turister som, påverkade av den kultur de kommer ifrån och den situation de befinner sig i som turist, väljer ett förhållningssätt till maten på resan. I rapporten framhålls det därför att lokala måltider kan utvecklas efter lokalt producerade livsmedel och efter lokala mattraditioner men att de också medvetet kan skapas, inspirerade av nutid och andra kulturer, och därefter bli en del av ett resmåls kultur. Rapporten beskriver även turistmåltider utifrån ett kommunikationsperspektiv, där måltiden, likt ett tal, kan vara mer eller mindre övertygande. Detta retoriska tankesätt är ett nytt och fruktbart sätt att studera måltider. Skapande utvecklingskraft finns hos en del av turistföretag i Sveriges inland idag. Det visar sig att de har ett budskap med sina måltider - de har en tanke med vad de vill åstadkomma. Andra företag saknar av olika skäl resurser för utveckling av turistmåltider, en del vet inte vad de vill åstadkomma, andra har inte omedelbara möjligheter att göra vad de skulle vilja. Det finns olika slag av turistmåltider. En del är vanliga måltider med primärt syfte att tillfredsställa ett närings- och energibehov. Andra tjänar syftet att vara lockande för turister. Dessa turistmåltider är då ett skäl varför turisten väljer ett resmål framför ett annat och de kan därför användas som platsmarkörer i reklam och marknadsföring. Turistmåltider kan också ses som attraktioner och upplevelser. En exotisk hälsomåltid kan tillhöra ett resmåls attraktioner medan den samtidigt kan vara en estetisk upplevelse för en turist. Det som lockar turisten är därför inte alltid attraktionen i sig. Turistmåltiden som social och berikande händelse diskuteras med utgångspunkt i att turism i sig är ett betydelsefullt socialt fenomen. Turistföretagarnas förhållningssätt till turistmåltiden i den egna verksamheten och till destinationsutveckling verkar ha en social betydelse för företagarna. Att skapa lokala måltider genom att göra det lokala, inklusive det egna företagandet, närvarande i måltiden ger turistföretagarna en riktlinje för innehållet i turistmåltiden. Destinationer kan därför skapa sina kompetenser med olika slags kök, kök som i ett sammanhang skapar möjligheter för såväl turister som producenter att utvecklas. Det geografiska området svenska inlandet beskrivs med utgångspunkt från Inlandsvägen. Bygderna som vägen passerar igenom presenteras liksom hur turismen och turistmåltiderna gestaltar sig. Det konstateras att det turistiska utbudet kännetecknas av en splittrande mångfald och att Inlandsvägen idag saknar en identitet som resled. I reklam används idag mat och måltider som försäljningsargument främst av enskilda boendeanläggningar. Destinationernas mat- och måltidsutbud får sällan ett eget utrymme, och utbudet används inte som imageskapande för resmål längs Inlandsvägen. I rapporten beskrivs turistföretag i olika områden i det svenska inlandet med avseende på turistmåltider. Projektgruppen har, utifrån flertalet diskussioner med olika företagare om vad de kan göra, sammanställt konkreta förslag för hur de olika verksamheterna kan utveckla sina turistmåltider. En modell för utveckling och analys av turistmåltider som attraktioner är en del av rapportens avslutning. Modellens konkreta förslag kan förhoppningsvis leda läsarens egna tankar vidare. Några personliga reflektioner över relationen mellan turistmåltiden som attraktion och upplevelse finns också i slutkapitlet. En fortsatt forskning om de turistvärden som finns i turistmåltider som attraktioner och de som finns i turistmåltider som upplevelser föreslås. Andra forskningsfrågor värda att aktualisera är organisation av och kring attraktioner samt av och kring upplevelser. Just begreppet upplevelser har blivit ett framträdande ord inom turism och måltider samtidigt som forskningen inom dessa vetenskaper hellre inriktat sig på attraktionens och måltidens konkreta innehåll än upplevelsens innehåll.
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| 32. |
- Botling, Johan, et al.
(författare)
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CD49f (alpha 6 integrin) and CD66a (BGP) are specifically induced by retinoids during human monocytic differentiation
- 1995
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Ingår i: Leukemia. - 0887-6924 .- 1476-5551. ; 9:12, s. 2034-41
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Tidskriftsartikel (refereegranskat)abstract
- Retinoic acid (RA) and 1,25(OH)2-cholecalciferol (VitD3) are potent regulators of normal and malignant myeloid cells. In the human monoblast cell line U-937 they induce terminal differentiation, and the resulting phenotypes display both common and distinct, inducer-specific, properties. This paper shows that in U-937 cells the two retinoids, all-trans and 9-cis RA, induced the expression of CD49f (alpha 6 integrin subunit) and CD66a (biliary glycoprotein, BGP) mRNA and protein. In contrast, expression of CD49f and CD66a was not found in untreated or VitD3-induced cells. Cytokine-induced modulation of CD49f and CD66a expression was restricted to the retinoid-induced U-937 cells. The retinoid specific induction of CD49f and CD66a was confirmed in the related monoblastic cell line THP-1. Human blood monocytes and the monocytic cell line Mono Mac 6 responded poorly to RA, with respect to the regulation of CD49f and CD66a expression, indicating that early monocytic precursors were targets for the retinoid-specific regulation. Thus, the expression of CD49f and CD66a is developmentally regulated and specifically induced by all-trans and 9-cis Ra in human monocytic cells.
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| 33. |
- Botling, Johan, et al.
(författare)
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Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation
- 1997
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Ingår i: Journal of Biological Chemistry. - : Elsevier BV. - 0021-9258 .- 1083-351X. ; 272:14, s. 9443-9
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Tidskriftsartikel (refereegranskat)abstract
- The receptor for 9-cis-retinoic acid, retinoid X receptor (RXR), forms heterodimers with several nuclear receptors, including the receptor for all-trans-retinoic acid, RAR. Previous studies have shown that retinoic acid receptor can be activated in RAR/RXR heterodimers, whereas RXR is believed to be a silent co-factor. In this report we show that efficient growth arrest and differentiation of the human monocytic cell line U-937 require activation of both RAR and RXR. Also, we demonstrate that the allosteric inhibition of RXR is not obligatory and that RXR can be activated in the RAR/RXR heterodimer in the presence of RAR ligands. Remarkably, RXR inhibition by RAR can also be relieved by an RAR antagonist. Moreover, the dose response of RXR agonists differ between RXR homodimers and RAR/RXR heterodimers, indicating that these complexes are pharmacologically distinct. Finally, the AF2 activation domain of both subunits contribute to activation even if only one of the receptors is associated with ligand. Our data emphasize the importance of signaling through both subunits of a heterodimer in the physiological response to retinoids and show that the activity of RXR is dependent on both the identity and the ligand binding state of its partner.
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| 34. |
- Botling, Johan, et al.
(författare)
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Vitamin D3 and retinoic acid induced monocytic differentiation : Interactions between the endogenous vitamin D3, retinoic acid and retinoid X receptors in U-937 cells
- 1996
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Ingår i: Cell growth & differentiation. - 1044-9523. ; 7:9, s. 1239-49
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Tidskriftsartikel (refereegranskat)abstract
- Retinoic acid (RA) and 1,25 alpha-dihydroxycholecalciferol (VitD3) are potent regulators of hematopoletic differentiation. Yet, little is known as to how the RA and VitD3 receptor network operates in hematopoietic cells, and whether receptor interactions can explain the interplay between the RA- and VitD3-signaling pathways during differentiation. Therefore, we analyzed the expression, DNA binding, and transcriptional activity of the endogenous RA and VitD3 receptors [retinoic acid receptors (RARs), retinoid X receptors (RXRs), and VitD3 receptor (VDR)] in the U-937 cell line, in which RA and VitD3 induce distinct monocytic differentiation pathways. VitD3 induction resulted in the formation of VDR/RXR DNA-binding complexes on both VitD3 response elements and RA response elements (RAREs). However, transcriptional activation was only observed from a VitD3 response element-driven reporter construct. Several DNA-binding complexes were detected on RAREs in undifferentiated cells. Stimulation by RA resulted in increased RAR beta/RXR DNA binding, activated RARE-dependent transcription, and increased expression of RAR-beta. Concomitant stimulation by VitD3 inhibited the RA-stimulated formation of RAR beta/RXR heterodimers, favoring VDR/RXR binding to the RARE. Also, VitD3 inhibited the expression of CD23 and CD49f, characteristic markers of retinoid-induced U-937 cell differentiation. In contrast, neither the RA-stimulated, RARE-mediated transcription nor the induced RAR-beta expression was suppressed by VitD3, suggesting that VitD3 selectively inhibited the retinoid-induced differentiation program but not the RARE-mediated signal. These results demonstrate a complex role for VitD3 in modifying the retinoid differentiation pathway and may have implications for differentiation-inducing therapy of hematopoietic tumors.
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| 35. |
- Corkhill, Emma, et al.
(författare)
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Manifestations
- 2008
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Ingår i: ArtMonitor. - 1653-9958. ; 3:5, s. 5024-5033
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Tidskriftsartikel (refereegranskat)abstract
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| 36. |
- Cotgreave, Ian, et al.
(författare)
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Pyriproxifen and microcephaly: an investigation of potential ties to the ongoing "Zika epidemic"
- 2016
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- As part of the Swetox mission to react to emerging concerns in chemical health and environmental safety, a preliminary litterature investigation was undertaken to gather all readily available scientific information on PPF with respect to safety assessment, in order to better understand potential links between chemical exposure and the devopment of microcephaly in affected areas. Therefore the contents of the report do not constitute an attempt at either questioning the use of existing regulatory data in the manner prescribed by international regulatory proceedures, or as a new risk assessment, based on the scientific information and concepts discussed. Here we report our findings, with particular emphasis on exisiting regulatory information, potential for lack of translation of results from regulatory animal testing to humans, lack of human exposure data and suggestions on plausible mode(s) of action of PPF in human neurodevelopmental adversities such as microcephaly.
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| 37. |
- Dahlin, Peter, 1981-, et al.
(författare)
-
Including Customers and Suppliers in the Understanding of Mergers and Acquisitions
- 2015
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Konferensbidrag (refereegranskat)abstract
- Mergers and acquisitions (M&A) is a common foreign market entry mode. The M&A-literature is multi-disciplinary and the understanding of M&As is the result of many different perspectives, e.g. economics, finance, strategy and organizational management. Both internationalization and M&A are closely related to growth, and share many challenges.The Uppsala-model of internationalization showed how the business network is a key factor in the choices and process during internationalization. With M&As being important to internationalization, the M&A research should have a similar view of companies and markets. In this paper, we review articles on M&As to find out in what way customers and suppliers are recognized. To what extent are customers and suppliers included in the M&A literature? And how are their roles and stakes in M&As described?Based on an analysis of 1,632 articles, the study builds a categorization of six ways of including customers and suppliers in M&A literature. It is shown that customers and suppliers, when included in M&A literature, are predominantly treated as passive and reactive stakeholders. There seems to be a need for a clearer theoretical framework of the role customers and suppliers can have in M&As.
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| 38. |
- Danared, Håkan, et al.
(författare)
-
Preface
- 2017
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Ingår i: IPAC 2018 : Proceedings of the 8th International Particle Accelerator Conference - Proceedings of the 8th International Particle Accelerator Conference. - 9783954501823
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 39. |
- Fagius, Jan, et al.
(författare)
-
Early highly aggressive MS successfully treated by hematopoietic stem cell transplantation
- 2009
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Ingår i: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 15:2, s. 229-237
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: During the last 15 years, high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HSCT) has globally been performed for severe multiple sclerosis (MS). Most patients have been in progressive phase with long disease duration. As a rule, treatment effect has been minor or moderate. PATIENTS: Since 2004, we have performed HSCT in nine young patients with "malignant" relapsing-remitting MS. Criteria for treatment were short duration of disease; very frequent, severe relapses; recent improvement periods indicating potential for recovery after strong immunosuppression. FINDINGS: Median age at treatment was 27 (range 9-34) years, MS duration 26 (4-100) months, and annualized relapse rate 10 (4-12). Median Disability Status Scale (extended disability status scale, EDSS) at HSCT was 7.0 (3.5-8.0). Median follow-up time April 2008 is 29 (23-47) months. Median EDSS improvement is 3.5 (1.0-7.0), clearly surpassing most previous reports. One patient relapsed mildly with rapid recovery 7 months after HSCT. All patients are otherwise stable, median EDSS being 2.0 (0-6.0). Before HSCT, 61 relapses occurred in 82 patient months; during follow-up, one relapse in 289 patient months. CONCLUSION: This small series of patients with "malignant" relapsing-remitting MS suggests HSCT to be an effective treatment option for this relatively rare disease course. It further suggests that future criteria for HSCT in MS should be close to the present ones.
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| 40. |
- Fayolle, E. C., et al.
(författare)
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Protostellar and cometary detections of organohalogens
- 2017
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Ingår i: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 1:10, s. 703-708
-
Tidskriftsartikel (refereegranskat)abstract
- Organohalogens, a class of molecules that contain at least one halogen atom bonded to carbon, are abundant on the Earth where they are mainly produced through industrial and biological processes(1). Consequently, they have been proposed as biomarkers in the search for life on exoplanets(2). Simple halogen hydrides have been detected in interstellar sources and in comets, but the presence and possible incorporation of more complex halogen-containing molecules such as organohalogens into planet-forming regions is uncertain(3,4). Here we report the interstellar detection of two isotopologues of the organohalogen CH3Cl and put some constraints on CH3F in the gas surrounding the low-mass protostar IRAS 16293-2422, using the Atacama Large Millimeter/submillimeter Array (ALMA). We also find CH3Cl in the coma of comet 67P/Churyumov-Gerasimenko (67P/C-G) by using the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) instrument. The detections reveal an efficient pre-planetary formation pathway of organohalogens. Cometary impacts may deliver these species to young planets and should thus be included as a potential abiotical production source when interpreting future organohalogen detections in atmospheres of rocky planets.
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| 41. |
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| 42. |
- Fransson, Göran, 1968-, et al.
(författare)
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On the Swedish National Grade School for Digital Technologies in Education – GRADE : Expectations and experiences of doctorial students and supervisors
- 2018
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Ingår i: ICERI2018 Proceedings. - Sevilla : IATED. - 9788409059485 ; , s. 769-774
-
Konferensbidrag (refereegranskat)abstract
- The Swedish National Graduate School for Digital Technologies in Education (GRADE) is a cooperative venture between six Swedish universities established during 2018. Within the field of educational sciences and in the area of digital technologies in education, GRADE aims to strengthen the expertise in the area and to increase national and international cooperation in research training activities.Over a number of years, and from multitude of sources (cf. Brown & Davis, 2004; Fisher, Higgins & Loveless, 2006; Kafai & Resnick 1996), research has stressed that increased digitalization in schools leads to a complexity that needs to be taken into account on different levels, from different perspectives and with different designs, methodologies and theoretical perspectives (cf. Olofsson, Lindberg, Fransson & Hauge, 2015; Price, Jewitt & Brown, 2013; Tondeur, Valcke & van Braak, 2008). At a micro-level, the learning situation of students, teachers and school-leaders changes and it becomes important to deepen the knowledge about the impact digital technologies has on the fundamental conditions for teaching and learning of different school subjects (cf. Chun, Kern & Smith 2016; Leung & Baccaglini-Frank, 2017). On a macro-level, conditions for education as such changes and digital technologies becomes an important object of study as agents of change (Wong & Li, 2008). The digitalization of K-12 schools has long been highlighted in policy as a necessity (cf. Kirkman et al, 2002; OECD, 2010). However, research and evaluations (cf. Fransson et al, 2012; OECD, 2015; Wastiau et al, 2013) show that many substantial challenges remain. One of the fundamental pillars of GRADE is the interdisciplinary approach. Several disciplines are present (Applied IT, Curriculum studies, Education, Informatics, Technology and Learning, Educational work, Work-interated Learning) in researching digital technologies in K-12 schools with the ambition to contribute to the continued implementation, integration and use of digital technologies in Swedish K-12 schools that stems from the evidence-based knowledge produced within the activities of GRADE. The research within GRADE will be characterized by close cooperation with stakeholders from school practice, with the aim to contribute to concrete school development. In GRADE, a multi-level approach that involves multiple layers or levels of school activities will be encouraged. When possible, studies will be longitudinal. This will imply studies from an organizational and management perspective, e.g. studies of school leaders and other members of senior management positions responsible for digital technology use and implementation. Also implied are studies of teachers' teaching practices and didactical considerations, as well as studies of the students in classrooms and their learning using digital technologies. This will also imply that several issues with a bearing on the digitalization of education, for example regarding school policy, teaching, learning, assessment and professional development will be researched from different perspectives and with different methodological approaches. In this paper, these points of departure will be explored based on the expectations and experiences of the first twelve admitted doctoral students and their supervisors.
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| 43. |
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| 44. |
- Hallberg, Peter, 1965-, et al.
(författare)
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Quality management systems as indicators for stability and change in customer-supplier relationships
- 2018
-
Ingår i: The IMP Journal. - : Emerald Group Publishing Limited. - 2059-1403 .- 0809-7259. ; 12:3, s. 483-497
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: This paper extends the discussion on stability and change through focus on specific relationship characteristics. Quality management systems prescribe established routines for supplier selection and monitoring, and may thereby designate the nature and longevity of customer-supplier relationships. The purpose of this paper is to describe and discuss the effects of quality management systems on stability and change in different forms of customer-supplier relationships.Design/methodology/approach: A number of illustrative examples based on participatory data and interviews help to capture different types of customer-supplier relationships (private/public; certified/non-certified) related to quality management systems.Findings: While certified customers in most sectors only need to prove that their suppliers have procedures in place, many customers equate this with requiring that their suppliers should be certified. The paper further shows that customers replace deeper understandings for their suppliers' procedures with the requirement that they be certified.Originality/value: The paper contributes to the existing literature through integrating quality management systems literature with the business network approach. For business network studies, the discussion on quality management systems as constricting regimes is interesting and provides practical insights to the business network studies as such quality management systems increase in importance and spread.
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| 45. |
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| 46. |
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| 47. |
- Holtström, Johan, 1968-, et al.
(författare)
-
Hur nås höga kursutvärderingar? : En studie av korrelationen mellan kursutvärderingar, nedlagd tid och studenters resultat på kurser
- 2009
-
Ingår i: Ett år med Bologna - vad har hänt vid LiU?. - Linköping : Linköping University Electronic Press. - 9789173935807 ; , s. 91-103
-
Bokkapitel (refereegranskat)abstract
- Kursutvärderingar har blivit allt viktigare. De fyller idag inte enbart en funktion av att utgöra underlag för förbättringar inom utbildningen, utan används även för att utvärdera lärarens insatser. I och med detta skulle det också kunna uppkomma intressen att försöka styra undervisningen för att uppnå höga kursutvärderingar. Diskussioner har bland annat handlat om att höga krav på studenterna påverkar kursutvärderingar negativt (se exempelvis Bjuremark, 2008) samt om det går att få bättre kursutvärderingar genom att ge studenter höga betyg. Syftet med detta papper är att undersöka sambanden mellan det betyg studenterna ger en kurs, deras studiearbetstid och det slutbetyg studenterna erhållit från kursen. Inom Linköpings universitet används det elektroniska kursutvärderingssystemet KURT där man bland annat frågar efter hur studenterna bedömer kursen som helhet på en femgradig skala och där studenterna ska ange genomsnittlig studiearbetstid under kursen. Genom att jämföra dessa värden med studenternas studieresultat avser pappret att besvara följande frågor: Finns det något samband mellan studenternas slutbetyg och det betyg de ger kursen?, Finns det något samband mellan nedlagd studietid och studenternas slutbetyg? Och, finns det något samband mellan nedlagd tid och det betyg studenterna ger kursen? Som underlag för undersökningen använder vi data från 230 kurser inom ekonomi på teknisk fakultet vid Linköpings Universitet. Vi drar slutsatsen att medan det inte finns någon signifikant korrelation mellan nedlagd tid och studieresultat eller mellan kursutvärdering och studieresultat, så finns positiv korrelation mellan nedlagd tid och kursutvärdering. Dessa slutsatser är intressanta att lyfta fram kopplat till diskussioner om kursutvärderingar och studieprestationer, då de indikerar att (i) det inte lönar sig att ge enkla kurser för att få en bra kursutvärdering, (ii) en hög arbetsinsats primärt premierar kursen, medan studenten faktiskt inte når en bättre prestation, och (iii) att ge höga betyg till studenter inte premierar kursutvärderingen.
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| 48. |
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| 49. |
- Holtström, Johan, 1968-, et al.
(författare)
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M&A Effects on Procurement
- 2004
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Ingår i: Annual IPSERA Conference,2004.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 50. |
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