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- Ödling Davidsson, Fredrik, et al.
(författare)
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Reversal of Heparin After Cardiac Surgery : Protamine Titration Using a Statistical Model
- 2015
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Ingår i: Journal of Cardiothoracic and Vascular Anesthesia. - : Elsevier BV. - 1053-0770 .- 1532-8422. ; 29:3, s. 710-714
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To establish a statistical model for determination of protamine dose in conjunction with cardiopulmonary bypass. Design: Prospective.Setting: University hospital.Participants: Ninety consecutive cardiac surgical patients.Interventions: None.Measurements and Main Results: A series of clinically oriented variables were introduced into a statistical model for projection of the protamine dose after cardiopulmonary bypass. The following significant predictors were identified using multivariable regression analysis: The patient's body surface area, the administered dose of heparin, heparin clearance, and the preoperative platelet count. The statistical model projected the protamine dose within 3 +/- 23 mg of the point-of-care test used as reference.Conclusion: Protamine dosing based on statistical modeling represents an alternative to point-of-care tests.
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