| 1. |
- Figlioli, G, et al.
(författare)
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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
- 2019
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Ingår i: NPJ breast cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 5, s. 38-
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.
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| 2. |
- Meech, K. J., et al.
(författare)
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EPOXI: Comet 103P/Hartley 2 Observations from a Worldwide Campaign
- 2011
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Ingår i: Astrophysical Journal Letters. - London : IOP. - 2041-8213 .- 2041-8205. ; 734:L1, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Earth- and space-based observations provide synergistic information for space mission encounters by providing data over longer timescales, at different wavelengths and using techniques that are impossible with an in situ flyby. We report here such observations in support of the EPOXI spacecraft flyby of comet 103P/Hartley 2. The nucleus is small and dark, and exhibited a very rapidly changing rotation period. Prior to the onset of activity, the period was ~16.4?hr. Starting in 2010 August the period changed from 16.6?hr to near 19?hr in December. With respect to dust composition, most volatiles and carbon and nitrogen isotope ratios, the comet is similar to other Jupiter-family comets. What is unusual is the dominance of CO 2 -driven activity near perihelion, which likely persists out to aphelion. Near perihelion the comet nucleus was surrounded by a large halo of water-ice grains that contributed significantly to the total water production.
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| 3. |
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| 4. |
- Grun, E., et al.
(författare)
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The 2016 Feb 19 outburst of comet 67P/CG : an ESA Rosetta multi-instrument study
- 2016
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 462, s. S220-S234
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Tidskriftsartikel (refereegranskat)abstract
- On 2016 Feb 19, nine Rosetta instruments serendipitously observed an outburst of gas and dust from the nucleus of comet 67P/Churyumov-Gerasimenko. Among these instruments were cameras and spectrometers ranging from UV over visible to microwave wavelengths, in situ gas, dust and plasma instruments, and one dust collector. At 09: 40 a dust cloud developed at the edge of an image in the shadowed region of the nucleus. Over the next two hours the instruments recorded a signature of the outburst that significantly exceeded the background. The enhancement ranged from 50 per cent of the neutral gas density at Rosetta to factors > 100 of the brightness of the coma near the nucleus. Dust related phenomena (dust counts or brightness due to illuminated dust) showed the strongest enhancements (factors > 10). However, even the electron density at Rosetta increased by a factor 3 and consequently the spacecraft potential changed from similar to-16 V to -20 V during the outburst. A clear sequence of events was observed at the distance of Rosetta ( 34 km from the nucleus): within 15 min the Star Tracker camera detected fast particles (similar to 25 m s(-1)) while 100 mu m radius particles were detected by the GIADA dust instrument similar to 1 h later at a speed of 6 m s(-1). The slowest were individual mm to cm sized grains observed by the OSIRIS cameras. Although the outburst originated just outside the FOV of the instruments, the source region and the magnitude of the outburst could be determined.
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| 5. |
- Snodgrass, C., et al.
(författare)
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The 67P/Churyumov-Gerasimenko observation campaign in support of the Rosetta mission
- 2017
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Ingår i: Philosophical Transactions. Series A. - : The Royal Society. - 1364-503X .- 1471-2962. ; 375:2097
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Tidskriftsartikel (refereegranskat)abstract
- We present a summary of the campaign of remote observations that supported the European Space Agency's Rosetta mission. Telescopes across the globe (and in space) followed comet 67P/ Churyumov-Gerasimenko from before Rosetta's arrival until nearly the end of the mission in September 2016. These provided essential data for mission planning, large-scale context information for the coma and tails beyond the spacecraft and a way to directly compare 67P with other comets. The observations revealed 67P to be a relatively 'well-behaved' comet, typical of Jupiter family comets and with activity patterns that repeat from orbit to orbit. Comparison between this large collection of telescopic observations and the in situ results from Rosetta will allow us to better understand comet coma chemistry and structure. This work is just beginning as the mission ends-in this paper, we present a summary of the ground-based observations and early results, and point to many questions that will be addressed in future studies. This article is part of the themed issue 'Cometary science after Rosetta'.
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| 6. |
- Kueppers, Michael, et al.
(författare)
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Triple F-a comet nucleus sample return mission
- 2009
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:3, s. 809-847
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Tidskriftsartikel (refereegranskat)abstract
- The Triple F (Fresh From the Fridge) mission, a Comet Nucleus Sample Return, has been proposed to ESA's Cosmic Vision program. A sample return from a comet enables us to reach the ultimate goal of cometary research. Since comets are the least processed bodies in the solar system, the proposal goes far beyond cometary science topics (like the explanation of cometary activity) and delivers invaluable information about the formation of the solar system and the interstellar molecular cloud from which it formed. The proposed mission would extract three sample cores of the upper 50 cm from three locations on a cometary nucleus and return them cooled to Earth for analysis in the laboratory. The simple mission concept with a touch-and-go sampling by a single spacecraft was proposed as an M-class mission in collaboration with the Russian space agency ROSCOSMOS.
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| 7. |
- Fulle, M., et al.
(författare)
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Evolution Of The Dust Size Distribution Of Comet 67P/Churyumov-Gerasimenko From 2.2 Au To Perihelion
- 2016
-
Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 821:1
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Tidskriftsartikel (refereegranskat)abstract
- The Rosetta probe, orbiting Jupiter-family comet 67P/Churyumov-Gerasimenko, has been detecting individual dust particles of mass larger than 10(-10) kg by means of the GIADA dust collector and the OSIRIS Wide Angle Camera and Narrow Angle Camera since 2014 August and will continue until 2016 September. Detections of single dust particles allow us to estimate the anisotropic dust flux from 67P, infer the dust loss rate and size distribution at the surface of the sunlit nucleus, and see whether the dust size distribution of 67P evolves in time. The velocity of the Rosetta orbiter, relative to 67P, is much lower than the dust velocity measured by GIADA, thus dust counts when GIADA is nadir-pointing will directly provide the dust flux. In OSIRIS observations, the dust flux is derived from the measurement of the dust space density close to the spacecraft. Under the assumption of radial expansion of the dust, observations in the nadir direction provide the distance of the particles by measuring their trail length, with a parallax baseline determined by the motion of the spacecraft. The dust size distribution at sizes > 1 mm observed by OSIRIS is consistent with a differential power index of -4, which was derived from models of 67P's trail. At sizes <1 mm, the size distribution observed by GIADA shows a strong time evolution, with a differential power index drifting from -2 beyond 2 au to -3.7 at perihelion, in agreement with the evolution derived from coma and tail models based on ground-based data. The refractory-to-water mass ratio of the nucleus is close to six during the entire inbound orbit and at perihelion.
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| 8. |
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| 9. |
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| 10. |
- Dork, T, et al.
(författare)
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Two truncating variants in FANCC and breast cancer risk
- 2019
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 12524-
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Tidskriftsartikel (refereegranskat)abstract
- Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk associations of others remain unknown. The gene for FA type C, FANCC, has been proposed as a breast cancer susceptibility gene based on epidemiological and sequencing studies. We used the Oncoarray project to genotype two truncating FANCC variants (p.R185X and p.R548X) in 64,760 breast cancer cases and 49,793 controls of European descent. FANCC mutations were observed in 25 cases (14 with p.R185X, 11 with p.R548X) and 26 controls (18 with p.R185X, 8 with p.R548X). There was no evidence of an association with the risk of breast cancer, neither overall (odds ratio 0.77, 95%CI 0.44–1.33, p = 0.4) nor by histology, hormone receptor status, age or family history. We conclude that the breast cancer risk association of these two FANCC variants, if any, is much smaller than for BRCA1, BRCA2 or PALB2 mutations. If this applies to all truncating variants in FANCC it would suggest there are differences between FA genes in their roles on breast cancer risk and demonstrates the merit of large consortia for clarifying risk associations of rare variants.
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| 11. |
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| 12. |
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| 13. |
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| 14. |
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| 15. |
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| 16. |
- Gicquel, A., et al.
(författare)
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Modelling of the outburst on 2015 July 29 observed with OSIRIS cameras in the Southern hemisphere of comet 67P/Churyumov-Gerasimenko
- 2017
-
Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 469, s. S178-S185
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Tidskriftsartikel (refereegranskat)abstract
- Images of the nucleus and the coma (gas and dust) of comet 67P/Churyumov-Gerasimenko have been acquired by the OSIRIS (Optical, Spectroscopic and Infrared Remote Imaging System) cameras since 2014 March using both the wide-angle camera and the narrow-angle camera (NAC). We use images from the NAC camera to study a bright outburst observed in the Southern hemisphere on 2015 July 29. The high spatial resolution of the NAC is needed to localize the source point of the outburst on the surface of the nucleus. The heliocentric distance is 1.25 au and the spacecraft-comet distance is 186 km. Aiming to better understand the physics that led to the outgassing, we used the Direct Simulation Monte Carlo method to study the gas flow close to the nucleus and the dust trajectories. The goal is to understand the mechanisms producing the outburst. We reproduce the opening angle of the outburst in the model and constrain the outgassing ratio between the outburst source and the local region. The outburst is in fact a combination of both gas and dust, in which the active surface is approximately 10 times more active than the average rate found in the surrounding areas. We need a number of dust particles 7.83 x 10(11) to 6.90 x 10(15) (radius 1.97-185 mu m), which correspond to a mass of dust (220-21) x 10(3) kg.
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| 17. |
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| 18. |
- Liu, JJ, et al.
(författare)
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Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk
- 2020
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1, s. 9688-
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Tidskriftsartikel (refereegranskat)abstract
- In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is a prostate cancer risk allele, we evaluated the association between HOXB13 germline mutations and breast cancer risk in a previous study consisting of 3,270 familial non-BRCA1/2 breast cancer cases and 2,327 controls from the Netherlands. Although both recurrent HOXB13 mutations p.G84E and p.R217C were not associated with breast cancer risk, the risk estimation for p.R217C was not very precise. To provide more conclusive evidence regarding the role of HOXB13 in breast cancer susceptibility, we here evaluated the association between HOXB13 mutations and increased breast cancer risk within 81 studies of the international Breast Cancer Association Consortium containing 68,521 invasive breast cancer patients and 54,865 controls. Both HOXB13 p.G84E and p.R217C did not associate with the development of breast cancer in European women, neither in the overall analysis (OR = 1.035, 95% CI = 0.859–1.246, P = 0.718 and OR = 0.798, 95% CI = 0.482–1.322, P = 0.381 respectively), nor in specific high-risk subgroups or breast cancer subtypes. Thus, although involved in breast cancer progression, HOXB13 is not a material breast cancer susceptibility gene.
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| 19. |
- Pajola, M., et al.
(författare)
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The Agilkia boulders/pebbles size-frequency distributions : OSIRIS and ROLIS joint observations of 67P surface
- 2016
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 462, s. S242-S252
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Tidskriftsartikel (refereegranskat)abstract
- By using the images acquired by the OSIRIS (Optical, Spectroscopic and Infrared Remote Imaging System) and ROLIS (ROsetta Lander Imaging System) cameras, we derive the size-frequency distribution (SFD) of cometary pebbles and boulders covering the size range 0.05-30.0 m on the Agilkia landing site. The global SFD measured on OSIRIS images, reflects the different properties of the multiple morphological units present on Agilkia, combined with selection effects related to lifting, transport and redeposition. Contrarily, the different ROLIS SFD derived on the smooth and rough units may be related to their different regolith thickness present on Agilkia. In the thicker, smoother layer, ROLIS mainly measures the SFD of the airfall population which almost completely obliterates the signature of underlying boulders up to a size of the order of 1 m. This is well matched by the power-law index derived analysing coma particles identified by the grain analyser Grain Impact Analyser and Dust Accumulator. This result confirms the important blanketing dynamism of Agilkia. The steeper SFD observed in rough terrains from 0.4 to 2 m could point out intrinsic differences between northern and southern dust size distributions, or it may suggest that the underlying boulders 'peek through' the thinner airfall layer in the rough terrain, thereby producing the observed excess in the decimetre size range. Eventually, the OSIRIS SFD performed on the Philae landing unit may be due to water sublimation from a static population of boulders, affecting smaller boulders before the bigger ones, thus shallowing the original SFD.
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| 20. |
- Pajola, M., et al.
(författare)
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The pebbles/boulders size distributions on Sais : Rosetta's final landing site on comet 67P/Churyumov-Gerasimenko
- 2017
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 469:Suppl. 2, s. S636-S645
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Tidskriftsartikel (refereegranskat)abstract
- By using the imagery acquired by the Optical, Spectroscopic, and Infrared Remote Imaging System Wide-Angle Camera (OSIRISWAC), we prepare a high-resolution morphological map of the Rosetta Sais final landing site, characterized by an outcropping consolidated terrain unit, a coarse boulder deposit and a fine particle deposit. Thanks to the 0.014 m resolution images, we derive the pebbles/boulders size-frequency distribution (SFD) of the area in the size range of 0.07-0.70 m. Sais' SFD is best fitted with a two-segment differential power law: the first segment is in the range 0.07-0.26 m, with an index of -1.7 ± 0.1, while the second is in the range 0.26-0.50 m, with an index of -4.2 +0.4/-0.8. The 'knee' of the SFD, located at 0.26 m, is evident both in the coarse and fine deposits. When compared to the Agilkia Rosetta Lander Imaging System images, Sais surface is almost entirely free of the ubiquitous, cm-sized debris blanket observed by Philae. None the less, a similar SFD behaviour of Agilkia, with a steeper distribution above ~0.3 m, and a flatter trend below that, is observed. The activity evolution of 67P along its orbit provides a coherent scenario of how these deposits were formed. Indeed, different lift pressure values occurring on the two locations and at different heliocentric distances explain the presence of the cm-sized debris blanket on Agilkia observed at 3.0 au inbound. Contrarily, Sais activity after 2.1 au outbound has almost completely eroded the fine deposits fallen during perihelion, resulting in an almost dust-free surface observed at 3.8 au.
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| 21. |
- Ahearn, Thomas U., et al.
(författare)
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Common variants in breast cancer risk loci predispose to distinct tumor subtypes
- 2022
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Ingår i: Breast Cancer Research. - : Springer Nature. - 1465-5411 .- 1465-542X. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundGenome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear.MethodsAmong 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes.ResultsEighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions.ConclusionThis report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
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| 22. |
- Barucci, M. A., et al.
(författare)
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Detection of exposed H2O ice on the nucleus of comet 67P/Churyumov-Gerasimenko as observed by Rosetta OSIRIS and VIRTIS instruments
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 595
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Tidskriftsartikel (refereegranskat)abstract
- Context. Since the orbital insertion of the Rosetta spacecraft, comet 67P/Churyumov-Gerasimenko (67P) has been mapped by OSIRIS camera and VIRTIS spectro-imager, producing a huge quantity of images and spectra of the comet's nucleus. Aims. The aim of this work is to search for the presence of H2O on the nucleus which, in general, appears very dark and rich in dehydrated organic material. After selecting images of the bright spots which could be good candidates to search for H2O ice, taken at high resolution by OSIRIS, we check for spectral cubes of the selected coordinates to identify these spots observed by VIRTIS. Methods. The selected OSIRIS images were processed with the OSIRIS standard pipeline and corrected for the illumination conditions for each pixel using the Lommel-Seeliger disk law. The spots with higher I/F were selected and then analysed spectrophotometrically and compared with the surrounding area. We selected 13 spots as good targets to be analysed by VIRTIS to search for the 2 mu m absorption band of water ice in the VIRTIS spectral cubes. Results. Out of the 13 selected bright spots, eight of them present positive H2O ice detection on the VIRTIS data. A spectral analysis was performed and the approximate temperature of each spot was computed. The H2O ice content was confirmed by modeling the spectra with mixing (areal and intimate) of H2O ice and dark terrain, using Hapke's radiative transfer modeling. We also present a detailed analysis of the detected spots.
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| 23. |
- Coignard, J, et al.
(författare)
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A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
- 2021
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 1078-
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers.
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| 24. |
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| 25. |
- El-Maarry, M. R., et al.
(författare)
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Fractures on comet 67P/Churyumov-Gerasimenko observed by Rosetta/OSIRIS
- 2015
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Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 42:13, s. 5170-5178
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Tidskriftsartikel (refereegranskat)abstract
- The Optical, Spectroscopic, and Infrared Remote Imaging System (OSIRIS) experiment onboard the Rosetta spacecraft currently orbiting comet 67P/Churyumov-Gerasimenko has yielded unprecedented views of a comet's nucleus. We present here the first ever observations of meter-scale fractures on the surface of a comet. Some of these fractures form polygonal networks. We present an initial assessment of their morphology, topology, and regional distribution. Fractures are ubiquitous on the surface of the comet's nucleus. Furthermore, they occur in various settings and show different topologies suggesting numerous formation mechanisms, which include thermal insulation weathering, orbital-induced stresses, and possibly seasonal thermal contraction. However, we conclude that thermal insolation weathering is responsible for creating most of the observed fractures based on their morphology and setting in addition to thermal models that indicate diurnal temperature ranges exceeding 200K and thermal gradients of similar to 15K/min at perihelion are possible. Finally, we suggest that fractures could be a facilitator in surface evolution and long-term erosion.
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| 26. |
- Fornasier, S., et al.
(författare)
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Rosetta's comet 67P/Churyumov-Gerasimenko sheds its dusty mantle to reveal its icy nature
- 2016
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 354:6319, s. 1566-1570
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Tidskriftsartikel (refereegranskat)abstract
- The Rosetta spacecraft has investigated comet 67P/Churyumov-Gerasimenko from large heliocentric distances to its perihelion passage and beyond. We trace the seasonal and diurnal evolution of the colors of the 67P nucleus, finding changes driven by sublimation and recondensation of water ice. The whole nucleus became relatively bluer near perihelion, as increasing activity removed the surface dust, implying that water ice is widespread underneath the surface. We identified large (1500 square meters) ice-rich patches appearing and then vanishing in about 10 days, indicating small-scale heterogeneities on the nucleus. Thin frosts sublimating in a few minutes are observed close to receding shadows, and rapid variations in color are seen on extended areas close to the terminator. These cyclic processes are widespread and lead to continuously, slightly varying surface properties.
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| 27. |
- Fornasier, S., et al.
(författare)
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The highly active Anhur-Bes regions in the 67P/Churyumov-Gerasimenko comet : results from OSIRIS/ROSETTA observations
- 2017
-
Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 469, s. S93-S107
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Tidskriftsartikel (refereegranskat)abstract
- The Southern hemisphere of the 67P/Churyumov-Gerasimenko comet has become visible from Rosetta only since 2015 March. It was illuminated during the perihelion passage and therefore it contains the regions that experienced the strongest heating and erosion rates, thus exposing the sub-surface most pristine material. In this work we investigate, thanks to the OSIRIS images, the geomorphology, the spectrophotometry and some transient events of two Southern hemisphere regions: Anhur and part of Bes. Bes is dominated by outcropping consolidated terrain covered with fine particle deposits, while Anhur appears strongly eroded with elongated canyon-like structures, scarp retreats, different kinds of deposits and degraded sequences of strata indicating a pervasive layering. We discovered a new 140 m long and 10 m high scarp formed in the Anhur-Bes boundary during/after the perihelion passage, close to the area where exposed CO2 and H2O ices were previously detected. Several jets have been observed originating from these regions, including the strong perihelion outburst, an active pit and a faint optically thick dust plume. We identify several areas with a relatively bluer slope (i.e. a lower spectral slope value) than their surroundings, indicating a surface composition enriched with some water ice. These spectrally bluer areas are observed especially in talus and gravitational accumulation deposits where freshly exposed material had fallen from nearby scarps and cliffs. The investigated regions become spectrally redder beyond 2 au outbound when the dust mantle became thicker, masking the underlying ice-rich layers.
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| 28. |
- Gicquel, A., et al.
(författare)
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Sublimation of icy aggregates in the coma of comet 67P/Churyumov-Gerasimenko detected with the OSIRIS cameras on board Rosetta
- 2016
-
Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 462, s. S57-S66
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Tidskriftsartikel (refereegranskat)abstract
- Beginning in 2014 March, the OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) cameras began capturing images of the nucleus and coma (gas and dust) of comet 67P/Churyumov-Gerasimenko using both the wide angle camera (WAC) and the narrow angle camera (NAC). The many observations taken since July of 2014 have been used to study the morphology, location, and temporal variation of the comet's dust jets. We analysed the dust monitoring observations shortly after the southern vernal equinox on 2015 May 30 and 31 with the WAC at the heliocentric distance R-h = 1.53 AU, where it is possible to observe that the jet rotates with the nucleus. We found that the decline of brightness as a function of the distance of the jet is much steeper than the background coma, which is a first indication of sublimation. We adapted a model of sublimation of icy aggregates and studied the effect as a function of the physical properties of the aggregates (composition and size). The major finding of this paper was that through the sublimation of the aggregates of dirty grains (radius a between 5 and 50 mu m) we were able to completely reproduce the radial brightness profile of a jet beyond 4 km from the nucleus. To reproduce the data, we needed to inject a number of aggregates between 8.5 x 10(13) and 8.5 x 10(10) for a = 5 and 50 mu m, respectively, or an initial mass of H2O ice around 22 kg.
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| 29. |
- Hu, X., et al.
(författare)
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Seasonal erosion and restoration of the dust cover on comet 67P/Churyumov-Gerasimenko as observed by OSIRIS onboard Rosetta
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 604
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Tidskriftsartikel (refereegranskat)abstract
- Context: Dust deposits or dust cover are a prevalent morphology in the northern hemi-nucleus of comet 67P /Churyumov-Gerasimenko (67P). The evolution of the dust deposits was captured by the OSIRIS camera system onboard the Rosetta spacecraft having escorted the comet for over two years. The observations shed light on the fundamental role of cometary activity in shaping and transforming the surface morphology.Aims: We aim to present OSIRIS observations of surface changes over the dust deposits before and after perihelion. The distribution of changes and a timeline of their occurrence are provided. We perform a data analysis to quantify the surface changes and investigate their correlation to water activity from the dust deposits. We further discuss how the results of our investigation are related to other findings from the Rosetta mission.Methods: Surface changes were detected via systematic comparison of images, and quantified using shape-from-shading technique. Thermal models were applied to estimate the erosion of water ice in response to the increasing insolation over the areas where surface changes occurred. Modeling results were used for the interpretation of the observed surface changes.Results: Surface changes discussed here were concentrated at mid-latitudes, between about 20 degrees N and 40 degrees N, marking a global transition from the dust-covered to rugged terrains. The changes were distributed in open areas exposed to ample solar illumination and likely subject to enhanced surface erosion before perihelion. The occurrence of changes followed the southward migration of the sub-solar point across the latitudes of their distribution. The erosion at locations of most changes was at least about 0 : 5 m, but most likely did not exceed several meters. The erosive features before perihelion had given way to a fresh, smooth cover of dust deposits after perihelion, suggesting that the dust deposits had been globally restored by at least about 1 m with ejecta from the intensely illuminated southern hemi-nucleus around perihelion, when the north was inactive during polar night.Conclusions: The erosion and restoration of the northern dust deposits are morphological expressions of seasonality on 67P. Based on observations and thermal modeling results, it is inferred that the dust deposits contained a few percent of water ice in mass on average. Local inhomogeneity in water abundance at spatial scales below tens of meters is likely. We suspect that dust ejected from the deposits may not have escaped the comet in bulk. That is, at least half of the ejected mass was afloat in the inner-coma or /and redeposited over other areas of the nucleus.
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| 30. |
- Pajola, M., et al.
(författare)
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The pristine interior of comet 67P revealed by the combined Aswan outburst and cliff collapse
- 2017
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Ingår i: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 1:5
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Tidskriftsartikel (refereegranskat)abstract
- Outbursts occur commonly on comets(1) with different frequencies and scales(2,3). Despite multiple observations suggesting various triggering processes(4,5), the driving mechanism of such outbursts is still poorly understood. Landslides have been invoked(6) to explain some outbursts on comet 103P/Hartley (2), although the process required a pre-existing dust layer on the verge of failure. The Rosetta mission observed several outbursts from its target comet 67P/ChuryumovGerasimenko, which were attributed to dust generated by the crumbling of materials from collapsing cliffs(7,8). However, none of the aforementioned works included definitive evidence that landslides occur on comets. Amongst the many features observed by Rosetta on the nucleus of the comet, one peculiar fracture, 70 m long and 1 m wide, was identified on images obtained in September 2014 at the edge of a cliff named Aswan(9). On 10 July 2015, the Rosetta Navigation Camera captured a large plume of dust that could be traced back to an area encompassing the Aswan escarpment(7). Five days later, the OSIRIS camera observed a fresh, sharp and bright edge on the Aswan cliff. Here we report the first unambiguous link between an outburst and a cliff collapse on a comet. We establish a new dust-plume formation mechanism that does not necessarily require the breakup of pressurized crust or the presence of supervolatile material, as suggested by previous studies(7). Moreover, the collapse revealed the fresh icy interior of the comet, which is characterized by an albedo > 0.4, and provided the opportunity to study how the crumbling wall settled down to form a new talus.
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| 31. |
- Schmitt, M. I., et al.
(författare)
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Long-term monitoring of comet 67P/Churyumov-Gerasimenko's jets with OSIRIS onboard Rosetta
- 2017
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 469, s. S380-S385
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Tidskriftsartikel (refereegranskat)abstract
- We used the OSIRIS camera system onboard the Rosetta spacecraft to monitor jet activity of comet 67P/Churyumov-Gerasimenko. With a monthly cadence, we covered an epoch from 2014 December to 2015 October, thereby including the first equinox and the perihelion passage. Jet features were measured in individual images, which were used to perform a statistical inversion. The study provides maps for the locations of likeliest sources of jet activity on the comet's surface as a function of time. The sources follow the subsolar latitude, show clustering and a broadening of the activity band with time in the Northern hemisphere. In the Southern hemisphere, they are not clustered but show a broader spread over all longitudes which is either related to the north-south dichotomy of the comet's topography or due to a higher insolation during southern summer.
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| 32. |
- Vincent, J. -B, et al.
(författare)
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Are fractured cliffs the source of cometary dust jets? : Insights from OSIRIS/Rosetta at 67P/Churyumov-Gerasimenko
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 587
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Tidskriftsartikel (refereegranskat)abstract
- Context: Dust jets (i.e., fuzzy collimated streams of cometary material arising from the nucleus) have been observed in situ on all comets since the Giotto mission flew by comet 1P/Halley in 1986, and yet their formation mechanism remains unknown. Several solutions have been proposed involving either specific properties of the active areas or the local topography to create and focus the gas and dust flows. While the nucleus morphology seems to be responsible for the larger features, high resolution imagery has shown that broad streams are composed of many smaller jets (a few meters wide) that connect directly to the nucleus surface.Aims: We monitored these jets at high resolution and over several months to understand what the physical processes are that drive their formation and how this affects the surface.Methods: Using many images of the same areas with different viewing angles, we performed a 3-dimensional reconstruction of collimated jets and linked them precisely to their sources on the nucleus.Results: We show here observational evidence that the northern hemisphere jets of comet 67P/Churyumov-Gerasimenko arise from areas with sharp topographic changes and describe the physical processes involved. We propose a model in which active cliffs are the main source of jet-like features and therefore of the regions eroding the fastest on comets. We suggest that this is a common mechanism taking place on all comets.
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| 33. |
- Vincent, J. -B, et al.
(författare)
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Summer fireworks on comet 67P
- 2016
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 462, s. S184-S194
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Tidskriftsartikel (refereegranskat)abstract
- During its 2 yr mission around comet 67P/Churyumov-Gerasimenko, ESA's Rosetta spacecraft had the unique opportunity to follow closely a comet in the most active part of its orbit. Many studies have presented the typical features associated with the activity of the nucleus, such as localized dust and gas jets. Here, we report on series of more energetic transient events observed during the 3 months surrounding the comet's perihelion passage in 2015 August. We detected and characterized 34 outbursts with the Rosetta cameras, one every 2.4 nucleus rotations. We identified three main dust plume morphologies associated with these events: a narrow jet, a broad fan, and more complex plumes featuring both previous types together. These plumes are comparable in scale and temporal variation to what has been observed on other comets. We present a map of the outbursts' source locations, and discuss the associated topography. We find that the spatial distribution sources on the nucleus correlate well with morphological region boundaries, especially in areas marked by steep scarps or cliffs. Outbursts occur either in the early morning or shortly after the local noon, indicating two potential processes: morning outbursts may be triggered by thermal stresses linked to the rapid change of temperature; afternoon events are most likely related to the diurnal or seasonal heat wave reaching volatiles buried under the first surface layer. In addition, we propose that some events can be the result of a completely different mechanism, in which most of the dust is released upon the collapse of a cliff.
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| 34. |
- Auger, A. -T, et al.
(författare)
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Geomorphology of the Imhotep region on comet 67P/Churyumov-Gerasimenko from OSIRIS observations
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 583
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Tidskriftsartikel (refereegranskat)abstract
- Context. Since August 2014, the OSIRIS Narrow Angle Camera (NAC) onboard the Rosetta spacecraft has acquired high spatial resolution images of the nucleus of comet 67P/Churyumov-Gerasimenko, down to the decimeter scale. This paper focuses on the Imhotep region, located on the largest lobe of the nucleus, near the equator. Aims. We map, inventory, and describe the geomorphology of the Imhotep region. We propose and discuss some processes to explain the formation and ongoing evolution of this region. Methods. We used OSIRIS NAC images, gravitational heights and slopes, and digital terrain models to map and measure the morphologies of Imhotep. Results. The Imhotep region presents a wide variety of terrains and morphologies: smooth and rocky terrains, bright areas, linear features, roundish features, and boulders. Gravity processes such as mass wasting and collapse play a significant role in the geomorphological evolution of this region. Cometary processes initiate erosion and are responsible for the formation of degassing conduits that are revealed by elevated roundish features on the surface. We also propose a scenario for the formation and evolution of the Imhotep region; this implies the presence of large primordial voids inside the nucleus, resulting from its formation process.
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| 35. |
- Davidsson, Björn, et al.
(författare)
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The primordial nucleus of comet 67P/Churyumov-Gerasimenko
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 592
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Tidskriftsartikel (refereegranskat)abstract
- Context. We investigate the formation and evolution of comet nuclei and other trans-Neptunian objects (TNOs) in the solar nebula and primordial disk prior to the giant planet orbit instability foreseen by the Nice model. Aims. Our goal is to determine whether most observed comet nuclei are primordial rubble-pile survivors that formed in the solar nebula and young primordial disk or collisional rubble piles formed later in the aftermath of catastrophic disruptions of larger parent bodies. We also propose a concurrent comet and TNO formation scenario that is consistent with observations. Methods. We used observations of comet 67P/Churyumov-Gerasimenko by the ESA Rosetta spacecraft, particularly by the OSIRIS camera system, combined with data from the NASA Stardust sample-return mission to comet 81P/Wild 2 and from meteoritics; we also used existing observations from ground or from spacecraft of irregular satellites of the giant planets, Centaurs, and TNOs. We performed modeling of thermophysics, hydrostatics, orbit evolution, and collision physics. Results. We find that thermal processing due to short-lived radionuclides, combined with collisional processing during accretion in the primordial disk, creates a population of medium-sized bodies that are comparably dense, compacted, strong, heavily depleted in supervolatiles like CO and CO2; they contain little to no amorphous water ice, and have experienced extensive metasomatism and aqueous alteration due to liquid water. Irregular satellites Phoebe and Himalia are potential representatives of this population. Collisional rubble piles inherit these properties from their parents. Contrarily, comet nuclei have low density, high porosity, weak strength, are rich in supervolatiles, may contain amorphous water ice, and do not display convincing evidence of in situ metasomatism or aqueous alteration. We outline a comet formation scenario that starts in the solar nebula and ends in the primordial disk, that reproduces these observed properties, and additionally explains the presence of extensive layering on 67P/Churyumov-Gerasimenko (and on 9P/Tempel 1 observed by Deep Impact), its bi-lobed shape, the extremely slow growth of comet nuclei as evidenced by recent radiometric dating, and the low collision probability that allows primordial nuclei to survive the age of the solar system. Conclusions. We conclude that observed comet nuclei are primordial rubble piles, and not collisional rubble piles. We argue that TNOs formed as a result of streaming instabilities at sizes below similar to 400 km and that similar to 350 of these grew slowly in a low-mass primordial disk to the size of Triton, Pluto, and Eris, causing little viscous stirring during growth. We thus propose a dynamically cold primordial disk, which prevented medium-sized TNOs from breaking into collisional rubble piles and allowed the survival of primordial rubble-pile comets. We argue that comets formed by hierarchical agglomeration out of material that remained after TNO formation, and that this slow growth was a necessity to avoid thermal processing by short-lived radionuclides that would lead to loss of supervolatiles, and that allowed comet nuclei to incorporate similar to 3 Myr old material from the inner solar system.
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| 36. |
- Dixon-Suen, Suzanne C, et al.
(författare)
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Physical activity, sedentary time and breast cancer risk : a Mendelian randomisation study
- 2022
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Ingår i: British Journal of Sports Medicine. - : BMJ Publishing Group Ltd. - 0306-3674 .- 1473-0480. ; 56:20, s. 1157-1170
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.METHODS: We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (nsnps=5) or sedentary time (nsnps=6), or accelerometer-measured (nsnps=1) or self-reported (nsnps=5) vigorous physical activity.RESULTS: Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger).CONCLUSION: Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women.
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| 37. |
- El-Maarry, M. R., et al.
(författare)
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Regional surface morphology of comet 67P/Churyumov-Gerasimenko from Rosetta/OSIRIS images
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 583
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Tidskriftsartikel (refereegranskat)abstract
- Aims. The OSIRIS camera onboard the Rosetta spacecraft has been acquiring images of the comet 67P/Churyumov-Gerasimenko (67P)'s nucleus at spatial resolutions down to similar to 0.17 m/px ever since Aug. 2014. These images have yielded unprecedented insight into the morphological diversity of the comet's surface. This paper presents an overview of the regional morphology of comet 67P. Methods. We used the images that were acquired at orbits similar to 20-30 km from the center of the comet to distinguish different regions on the surface and introduce the basic regional nomenclature adopted by all papers in this Rosetta special feature that address the comet's morphology and surface processes. We used anaglyphs to detect subtle regional and topographical boundaries and images from close orbit (similar to 10 km from the comet's center) to investigate the fine texture of the surface. Results. Nineteen regions have currently been defined on the nucleus based on morphological and/or structural boundaries, and they can be grouped into distinctive region types. Consolidated, fractured regions are the most common region type. Some of these regions enclose smooth units that appear to settle in gravitational sinks or topographically low areas. Both comet lobes have a significant portion of their surface covered by a dusty coating that appears to be recently placed and shows signs of mobilization by aeolian-like processes. The dusty coatings cover most of the regions on the surface but are notably absent from a couple of irregular large depressions that show sharp contacts with their surroundings and talus-like deposits in their interiors, which suggests that short-term explosive activity may play a significant role in shaping the comet's surface in addition to long-term sublimation loss. Finally, the presence of layered brittle units showing signs of mechanical failure predominantly in one of the comet's lobes can indicate a compositional heterogeneity between the two lobes.
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| 38. |
- El-Maarry, M. Ramy, et al.
(författare)
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Surface changes on comet 67P/Churyumov-Gerasimenko suggest a more active past
- 2017
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Ingår i: Science. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075 .- 1095-9203. ; 355:6332, s. 1392-
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Tidskriftsartikel (refereegranskat)abstract
- The Rosetta spacecraft spent similar to 2 years orbiting comet 67P/Churyumov-Gerasimenko, most of it at distances that allowed surface characterization and monitoring at submeter scales. From December 2014 to June 2016, numerous localized changes were observed, which we attribute to cometary-specific weathering, erosion, and transient events driven by exposure to sunlight and other processes. While the localized changes suggest compositional or physical heterogeneity, their scale has not resulted in substantial alterations to the comet's landscape. This suggests that most of the major landforms were created early in the comet's current orbital configuration. They may even date from earlier if the comet had a larger volatile inventory, particularly of CO or CO2 ices, or contained amorphous ice, which could have triggered activity at greater distances from the Sun.
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| 39. |
- El-Marry, M. R., et al.
(författare)
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Regional surface morphology of comet 67P/Churyumov-Gerasimenko from Rosetta/OSIRIS images : The southern hemisphere
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 593
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Tidskriftsartikel (refereegranskat)abstract
- Aims. The OSIRIS camera on board the Rosetta spacecraft has been acquiring images of the comet 67P/Churyumov-Gerasimenko (67P)'s nucleus since August 2014. Starting in May 2015, the southern hemisphere gradually became illuminated and was imaged for the first time. Here we present the regional morphology of the southern hemisphere, which serves as a companion to an earlier paper that presented the regional morphology of the northern hemisphere. Methods. We used OSIRIS images that were acquired at orbits similar to 45-125 km from the center of the comet (corresponding to spatial resolutions of similar to 0.8 to 2.3 m/pixel) coupled with the use of digital terrain models to define the different regions on the surface, and identify structural boundaries accurately. Results. Seven regions have been defined in the southern hemisphere bringing the total number of defined regions on the surface of the nucleus to 26. These classifications are mainly based on morphological and/or topographic boundaries. The southern hemisphere shows a remarkable dichotomy with its northern counterpart mainly because of the absence of wide-scale smooth terrains, dust coatings and large unambiguous depressions. As a result, the southern hemisphere closely resembles previously identified consolidated regions. An assessment of the overall morphology of comet 67P suggests that the comet's two lobes show surface heterogeneities manifested in different physical/mechanical characteristics, possibly extending to local (i.e., within a single region) scales.
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| 40. |
- Frattin, E., et al.
(författare)
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Post-perihelion photometry of dust grains in the coma of 67P Churyumov-Gerasimenko
- 2017
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Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 469, s. S195-S203
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Tidskriftsartikel (refereegranskat)abstract
- We present a photometric analysis of individual dust grains in the coma of comet 67P/Churyumov-Gerasimenko using OSIRIS images taken from 2015 July to 2016 January. We analysed a sample of 555 taken during 18 d at heliocentric distances ranging between 1.25 and 2.04 au and at nucleocentric distances between 80 and 437 km. An automated method to detect the tracks was specifically developed. The images were taken by OSIRIS NAC in four different filters: Near-IR (882 nm), Orange (649 nm), FarOrange (649 nm) and Blue (480 nm). It was not always possible to recognize all the grains in the four filters, hence we measured the spectral slope in two wavelengths ranges: in the interval [480-649] nm, for 1179 grains, and in the interval [649-882] nm, for 746 grains. We studied the evolution of the two populations' average spectral slopes. The data result scattered around the average value in the range [480-649] nm, while in the [649-882] nm we observe a slight decreasing moving away from the Sun as well as a slight increasing with the nucleocentric distance. A spectrophotometric analysis was performed on a subsample of 339 grains. Three major groups were defined, based on the spectral slope between [535-882] nm: (i) the steep spectra that may be related with organic material, (ii) the spectra with an intermediate slope, likely a mixture of silicates and organics and (iii) flat spectra that may be associated with a high abundance of water ice.
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| 41. |
- Giacomini, L., et al.
(författare)
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Geologic mapping of the Comet 67P/Churyumov-Gerasimenko's Northern hemisphere
- 2016
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 462, s. S352-S369
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Tidskriftsartikel (refereegranskat)abstract
- The Optical, Spectroscopic, and Infrared Remote Imaging System (OSIRIS), the scientific imaging system onboard the Rosetta mission, has been acquiring images of the nucleus of the comet 67P/Churyumov-Gerasimenko since 2014 August with a resolution which allows a detailed analysis of its surface. Indeed, data reveal a complex surface morphology which is likely the expression of different processes which occurred at different times on the cometary nucleus. In order to characterize these different morphologies and better understand their distribution, we performed a geologic mapping of comet's 67P Northern hemisphere in which features have been distinguished based on their morphological, textural and stratigraphic characteristics. For this purpose, we used narrow-angle camera images acquired in 2014 August and September with a spatial scale ranging from 1.2 to 2.4 m pixel(-1). Several different geologic units have been identified on the basis of their different surface textures, granulometry and morphology. Some of these units are distinctive and localized, whereas others are more common and distributed all over the Northern hemisphere. Moreover, different types of linear features have been distinguished on the basis of their morphology. Some of these lineaments have never been observed before on a comet and can offer important clues on the internal structures of the nucleus itself. The geologic mapping results presented here will allow us to better understand the processes which affected the nucleus' surface and thus the origin and evolutionary history of comet 67P/Churyumov-Gerasimenko.
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| 42. |
- Groussin, O., et al.
(författare)
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Gravitational slopes, geomorphology, and material strengths of the nucleus of comet 67P/Churyumov-Gerasimenko from OSIRIS observations
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 583
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We study the link between gravitational slopes and the surface morphology on the nucleus of comet 67P/Churyumov-Gerasimenko and provide constraints on the mechanical properties of the cometary material (tensile, shear, and compressive strengths). Methods. We computed the gravitational slopes for five regions on the nucleus that are representative of the different morphologies observed on the surface (Imhotep, Ash, Seth, Hathor, and Agilkia), using two shape models computed from OSIRIS images by the stereo-photoclinometry (SPC) and stereo-photogrammetry (SPG) techniques. We estimated the tensile, shear, and compressive strengths using different surface morphologies (overhangs, collapsed structures, boulders, cliffs, and Philae's footprint) and mechanical considerations. Results. The different regions show a similar general pattern in terms of the relation between gravitational slopes and terrain morphology: i) low-slope terrains (0-20 degrees) are covered by a fine material and contain a few large (>10 m) and isolated boulders; ii) intermediate-slope terrains (20-45 degrees) are mainly fallen consolidated materials and debris fields, with numerous intermediate-size boulders from <1m to 10m for the majority of them; and iii) high-slope terrains (45-90 degrees) are cliffs that expose a consolidated material and do not show boulders or fine materials. The best range for the tensile strength of overhangs is 3-15 Pa (upper limit of 150 Pa), 4-30 Pa for the shear strength of fine surface materials and boulders, and 30-150 Pa for the compressive strength of overhangs (upper limit of 1500 Pa). The strength-to-gravity ratio is similar for 67P and weak rocks on Earth. As a result of the low compressive strength, the interior of the nucleus may have been compressed sufficiently to initiate diagenesis, which could have contributed to the formation of layers. Our value for the tensile strength is comparable to that of dust aggregates formed by gravitational instability and tends to favor a formation of comets by the accrection of pebbles at low velocities.
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| 43. |
- Groussin, O., et al.
(författare)
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Temporal morphological changes in the Imhotep region of comet 67P/Churyumov-Gerasimenko
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 583
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We report on the first major temporal morphological changes observed on the surface of the nucleus of comet 67P/Churyumov-Gerasimenko in the smooth terrains of the Imhotep region. Methods. We used images of the OSIRIS cameras onboard Rosetta to follow the temporal changes from 24 May 2015 to 11 July 2015. Results. The morphological changes observed on the surface are visible in the form of roundish features that are growing in size from a given location in a preferential direction at a rate of 5.6-8.1 x 10(-5) m s(-1) during the observational period. The location where the changes started and the contours of the expanding features are bluer than the surroundings, which suggests that ices (H2O and/or CO2) are exposed on the surface. However, sublimation of ices alone is not sufficient to explain the observed expanding features. No significant variations in the dust activity pattern are observed during the period of changes.
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| 44. |
- Hu, X., et al.
(författare)
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Thermal modelling of water activity on comet 67P/Churyumov-Gerasimenko with global dust mantle and plural dust-to-ice ratio
- 2017
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Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 469, s. S295-S311
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Tidskriftsartikel (refereegranskat)abstract
- We perform a thermo-physical analysis on water activity of comet 67P/Churyumov-Gerasimenko (67P). The sublimation of water is assumed to occur from beneath a global, desiccated dust mantle over the irregular-shaped nucleus. The concept of two thermal models, the recipe of model formulation and the strategy of application to comet 67P are described. For an accurate and efficient evaluation of energy input by insolation and self-heating over the nucleus, a Landscape data base is devised based on polyhedral shape models of the nucleus. We apply the thermal models to investigate the impact of certain parameters of nucleus properties on water production. It is found that the measured water production of 67P can be overall attributed to sublimation of water ice with a mass abundance of a few to 10 per cent beneath a uniform dust mantle of several millimetres to one centimetre in thickness. Insofar as 67P is concerned, we argue against the necessity to invoke assumptions on localized water activity, or on the distinction of active/dormant surface areas.
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| 45. |
- Kapoor, Pooja Middha, et al.
(författare)
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Combined associations of a polygenic risk score and classical risk factors with breast cancer risk
- 2021
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 113:3, s. 329-337
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Tidskriftsartikel (refereegranskat)abstract
- We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.
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| 46. |
- La Forgia, F., et al.
(författare)
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Geomorphology and spectrophotometry of Philae's landing site on comet 67P/Churyumov-Gerasimenko
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 583
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Tidskriftsartikel (refereegranskat)abstract
- Context. On 12 November 2014 the European mission Rosetta succeeded in delivering a lander, named Philae, on the surface of one of the smallest, low-gravity and most primitive bodies of the solar system, the comet 67P/Churyumov-Gerasimenko (67P). Aims. The aim of this paper is to provide a comprehensive geomorphological and spectrophotometric analysis of Philae's landing site (Agilkia) to give an essential framework for the interpretation of its in situ measurements. Methods. OSIRIS images, coupled with gravitational slopes derived from the 3D shape model based on stereo-photogrammetry were used to interpret the geomorphology of the site. We adopted the Hapke model, using previously derived parameters, to photometrically correct the images in orange filter (649.2 nm). The best approximation to the Hapke model, given by the Akimov parameter-less function, was used to correct the reflectance for the effects of viewing and illumination conditions in the other filters. Spectral analyses on coregistered color cubes were used to retrieve spectrophotometric properties. Results. The landing site shows an average normal albedo of 6.7% in the orange filter with variations of similar to 15% and a global featureless spectrum with an average red spectral slope of 15.2%/100 nm between 480.7 nm (blue filter) and 882.1 nm (near-IR filter). The spatial analysis shows a well-established correlation between the geomorphological units and the photometric characteristics of the surface. In particular, smooth deposits have the highest reflectance a bluer spectrum than the outcropping material across the area. Conclusions. The featureless spectrum and the redness of the material are compatible with the results by other instruments that have suggested an organic composition. The observed small spectral variegation could be due to grain size effects. However, the combination of photometric and spectral variegation suggests that a compositional differentiation is more likely. This might be tentatively interpreted as the effect of the efficient dust-transport processes acting on 67P. High-activity regions might be the original sources for smooth fine-grained materials that then covered Agilkia as a consequence of airfall of residual material. More observations performed by OSIRIS as the comet approaches the Sun would help interpreting the processes that work at shaping the landing site and the overall nucleus.
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| 47. |
- Lara, L. M., et al.
(författare)
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Large-scale dust jets in the coma of 67P/Churyumov-Gerasimenko as seen by the OSIRIS instrument onboard Rosetta
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 583
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Tidskriftsartikel (refereegranskat)abstract
- Context. During the most recent perihelion passage in 2009 of comet 67P/Churyumov-Gerasimenko (67P), ground-based observations showed an anisotropic dust coma where jet-like features were detected at similar to 1.3 AU from the Sun. The current perihelion passage is exceptional as the Rosetta spacecraft is monitoring the nucleus activity since March 2014, when a clear dust coma was already surrounding the nucleus at 4.3 AU from the Sun. Subsequently, the OSIRIS camera also witnessed an outburst in activity between April 27 and 30, and since mid-July, the dust coma at rh similar to 3.7-3.6 AU preperihelion is clearly non-isotropic, pointing to the existence of dust jet-like features. Aims. We aim to ascertain on the nucleus surface the origin of the dust jet-like features detected as early as in mid-July 2014. This will help to establish how the localized comet nucleus activity compares with that seen in previous apparitions and will also help following its evolution as the comet approaches its perihelion, at which phase most of the jets were detected from ground-based observations. Determining these areas also allows locating them in regions on the nucleus with spectroscopic or geomorphological distinct characteristics. Methods. Three series of dust images of comet 67P obtained with the Wide Angle Camera (WAC) of the OSIRIS instrument onboard the Rosetta spacecraft were processed with different enhancement techniques. This was made to clearly show the existence of jet-like features in the dust coma, whose appearance toward the observer changed as a result of the rotation of the comet nucleus and of the changing observing geometry from the spacecraft. The position angles of these features in the coma together with information on the observing geometry, nucleus shape, and rotation, allowed us to determine the most likely locations on the nucleus surface where the jets originate from. Results. Geometrical tracing of jet sources indicates that the activity of the nucleus of 67P gave rise during July and August 2014 to large-scale jet-like features from the Hapi, Hathor, Anuket, and Aten regions, confirming that active regions may be present on the nucleus localized at 60. northern latitude as deduced from previous comet apparitions. There are also hints that large-scale jets observed from the ground are possibly composed, at their place of origin on the nucleus surface, of numerous small-scale features.
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| 48. |
- Lucchetti, A., et al.
(författare)
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Characterization of the Abydos region through OSIRIS high-resolution images in support of CIVA measurements
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 585
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Tidskriftsartikel (refereegranskat)abstract
- Context. On 12 November 2014, the European mission Rosetta delivered the Philae lander on the nucleus of comet 67P /Churyumov-Gerasimenko (67P). After the first touchdown, the lander bounced three times before finally landing at a site named Abydos. Aims. We provide a morphologically detailed analysis of the Abydos landing site to support Philae's measurements and to give context for the interpretation of the images coming from the Comet Infrared and Visible Analyser (CIVA) camera system onboard the lander. Methods. We used images acquired by the OSIRIS Narrow Angle Camera (NAC) on 6 December 2014 to perform the analysis of the Abydos landing site, which provided the geomorphological map, the gravitational slope map, the size-frequency distribution of the boulders. We also computed the albedo and spectral reddening maps. Results. The morphological analysis of the region could suggest that Philae is located on a primordial terrain. The Abydos site is surrounded by two layered and fractured outcrops and presents a 0.02 km(2) talus deposit rich in boulders. The boulder size frequency distribution gives a cumulative power-law index of 4.0 + 0.3/0.4, which is correlated with gravitational events triggered by sublimation and /or thermal fracturing causing regressive erosion. The average value of the albedo is 5.8% at lambda(1) = 480.7 nm and 7.4% at lambda(2) = 649.2 nm, which is similar to the global albedos derived by OSIRIS and CIVA, respectively.
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| 49. |
- Lucchetti, A., et al.
(författare)
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Geomorphological and spectrophotometric analysis of Seth's circular niches on comet 67P/Churyumov-Gerasimenko using OSIRIS images
- 2017
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Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 469, s. S238-S251
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Tidskriftsartikel (refereegranskat)abstract
- We provide a detailed geomorphological and spectrophotometric analysis of the circular niches located on the Seth region of 67P using OSIRIS images. The features can be related to landslide events that occurred on 67P and shaped its surface, as the recent Aswan cliff collapse detected in the same region. We therefore provide an analysis of the area pre -and post-perihelion suggesting that no specific changes have been observed. To assess this, after performing a geomorphological map of the area that allows us to identify different terrain units, we computed the boulders cumulative size frequency distribution (SFD) of the niches, before and after the perihelion passage. The niches SFDs are characterized by a similar trend with two different power-law indices within the same deposit: lower power-law value (between -2.3 and -2.7) for boulders smaller than 5 m and steeper power-law value (between -4.7 and -5.0) for boulders larger than 5 m. These trends suggest that smaller boulders have evolved and progressively have been depleted (lower power-law index), while bigger boulders are more representative of the event that generated the deposit and are less degraded. Then, we perform the spectrophotometric analysis of this region comparing pre-and post-perihelion results. We found colour changes within the area, in particular brighter patches related to the presence of exposed water ice mixed to the refractory materials have been detected in the post-perihelion images.
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| 50. |
- Mueller, Stefanie H., et al.
(författare)
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Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry
- 2023
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Ingår i: Genome Medicine. - : BioMed Central (BMC). - 1756-994X .- 1756-994X. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- Background: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.Methods: We evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.Results: In European ancestry samples, 14 genes were significantly associated (q < 0.05) with BC. Of those, two genes, FMNL3 (P = 6.11 x 10(-6)) and AC058822.1 (P = 1.47 x 10(-4)), represent new associations. High FMNL3 expression has previously been linked to poor prognosis in several other cancers. Meta-analysis of samples with diverse ancestry discovered further associations including established candidate genes ESR1 and CBLB. Furthermore, literature review and database query found further support for a biologically plausible link with cancer for genes CBLB, FMNL3, FGFR2, LSP1, MAP3K1, and SRGAP2C.Conclusions: Using extended gene-based aggregation tests including coding and regulatory variation, we report identification of plausible target genes for previously identified single-marker associations with BC as well as the discovery of novel genes implicated in BC development. Including multi ancestral cohorts in this study enabled the identification of otherwise missed disease associations as ESR1 (P = 1.31 x 10(-5)), demonstrating the importance of diversifying study cohorts.
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