| 1. |
- Sampson, Joshua N., et al.
(författare)
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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
- 2015
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 107:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
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| 4. |
- Adami, HO, et al.
(författare)
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Are rapidly growing cancers more lethal?
- 2017
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Ingår i: European journal of cancer (Oxford, England : 1990). - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 72, s. 210-214
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Adami, HO, et al.
(författare)
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Breast Cancer Screening and Diagnosis
- 2020
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Ingår i: Annals of internal medicine. - 1539-3704. ; 172:12, s. 839-840
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Adami, HO, et al.
(författare)
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Cervical cancer and the elusive male factor
- 2002
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Ingår i: The New England journal of medicine. - 1533-4406. ; 346:15, s. 1160-1161
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 14. |
- Adami, HO, et al.
(författare)
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Epidemiology, medicine and public health
- 1999
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Ingår i: International journal of epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 28:5, s. S1005-S1008
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| 18. |
- Adami, HO, et al.
(författare)
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Management of early prostate cancer
- 2014
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Ingår i: The New England journal of medicine. - 1533-4406. ; 370:22, s. 2151-2151
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 19. |
- Adami, HO, et al.
(författare)
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Miettinen's epidemiology: quo vadis?
- 2004
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Ingår i: European journal of epidemiology. - : Springer Science and Business Media LLC. - 0393-2990. ; 19:8, s. 737-739
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Tidskriftsartikel (refereegranskat)
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| 20. |
- Adami, HO, et al.
(författare)
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Obesity and mortality from cancer
- 2003
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Ingår i: The New England journal of medicine. - 1533-4406. ; 348:17, s. 1623-1624
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Tidskriftsartikel (refereegranskat)
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| 21. |
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| 25. |
- Adami, HO, et al.
(författare)
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Ranitidine Use and Risk of Upper Gastrointestinal Cancers
- 2021
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Ingår i: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. - 1538-7755. ; 30:12, s. 2302-2308
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Tidskriftsartikel (refereegranskat)
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| 26. |
- Adami, HO, et al.
(författare)
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Ranitidine Use and Risk of Upper Gastrointestinal Cancers-Reply
- 2022
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Ingår i: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. - 1538-7755. ; 31:4, s. 915-915
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 27. |
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| 30. |
- Adami, HO
(författare)
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The prostate cancer pseudo-epidemic
- 2010
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Ingår i: Acta oncologica (Stockholm, Sweden). - : Informa UK Limited. - 1651-226X .- 0284-186X. ; 49:3, s. 298-304
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 31. |
- Adami, HO, et al.
(författare)
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Time to abandon early detection cancer screening
- 2019
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Ingår i: European journal of clinical investigation. - : Wiley. - 1365-2362 .- 0014-2972. ; 49:3, s. e13062-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 47. |
- Andersson, SO, et al.
(författare)
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Body size and prostate cancer: A 20-year follow-up study among 135006 Swedish construction workers
- 1997
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Ingår i: JOURNAL OF THE NATIONAL CANCER INSTITUTE. - : NATL CANCER INSTITUTE. - 0027-8874. ; 89:5, s. 385-389
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Tidskriftsartikel (refereegranskat)abstract
- Background: Obesity is associated with endocrine changes (e.g., increased estrogen and decreased testosterone in the blood) that have been implicated in the cause of prostate cancer and, therefore, an association between body weight and the risk of develo
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| 48. |
- ANDERSSON, SO, et al.
(författare)
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EARLY-LIFE RISK-FACTORS FOR PROSTATE-CANCER - A POPULATION-BASED CASE-CONTROL STUDY IN SWEDEN
- 1995
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Ingår i: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. - : AMER ASSOC CANCER RESEARCH. - 1055-9965. ; 4:3, s. 187-192
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We undertook a population-based case-control study to investigate early life risk factors for prostate cancer. Information on dietary habits during childhood and adolescence, childhood environment, pubertal development, and physical activity was collected
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| 49. |
- Andersson, SO, et al.
(författare)
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Lifestyle factors and prostate cancer risk: A case-control study in Sweden
- 1996
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Ingår i: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. - : AMER ASSOC CANCER RESEARCH. - 1055-9965. ; 5:7, s. 509-513
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Tidskriftsartikel (refereegranskat)abstract
- We examined associations between lifestyle factors and subsequent risk of prostate cancer in a population-based case-control study, Information on smoking and alcohol habits, socioeconomic factors, marital status, family history, and sexual habits were ob
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| 50. |
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