| 1. |
- Mavroidis, P., et al.
(författare)
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Dose-Response Relations for Anal Sphincter Regarding Fecal Leakage and Blood or Phlegm in Stools after Radiotherapy for Prostate Cancer Radiobiological Study of 65 Consecutive Patients
- 2005
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Ingår i: Strahlenther Onkol. - 0179-7158. ; 181:5, s. 293-306
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: : The estimation of the parameters that describe the dose-response relations of anal sphincter regarding the clinical endpoints of fecal leakage and blood or phlegm in stools is important in the optimization of prostate cancer radiotherapy. Also, the validity of the relative seriality model for this clinical case needs to be examined by associating the clinical follow-up results with the predicted complication rates. PATIENTS AND METHODS: : In this study, 65 patients who received radiation therapy for clinically localized prostate adenocarcinoma are analyzed. The clinical treatment outcome and the three-dimensional dose distribution delivered to anal sphincter were available for each patient. A questionnaire was used for assessing the clinical bowel and urinary symptoms. A maximum likelihood fitting was performed to calculate the best estimates of the parameters used by the relative seriality model. The clinical utilization of the calculated parameters in predicting anal sphincter complication probabilities was illustrated by applying the best estimate of the parameters to a subset of the patient population. RESULTS: : The estimated values of the parameters for the two clinical endpoints are D (50) = 70.2 Gy, gamma = 1.22, s = 0.35 for fecal leakage and D (50) = 74.0 Gy, gamma = 0.75, s approximately 0 for blood or phlegm in stools. The standard deviations of the parameters were also calculated together with the confidence intervals of the dose-response curves. The analysis proved that the treatment outcome pattern of the patient material can suitably be reproduced by the relative seriality model (probability of finding a worse fit = 60.2%, the area under the receiver operating characteristic curve = 0.72 and 0.69 and chi(2)-test = 0.97 and 0.86, respectively). CONCLUSION: : Fecal leakage is characterized by a medium relative seriality whereas blood or phlegm in stools was found to have strong volume dependence (low relative seriality). Diminishing the biologically effective uniform dose to anal sphincter < 40-45 Gy may significantly reduce the risk of fecal leakage or blood or phlegm in stools for patients irradiated for prostate cancer.
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| 14. |
- Agren, K, et al.
(författare)
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Haemophilus influenzae and Streptococcus pyogenes group A challenge induce a Th1 type of cytokine response in cells obtained from tonsillar hypertrophy and recurrent tonsillitis
- 1998
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Ingår i: ORL. - : S. Karger AG. - 0301-1569 .- 1423-0275. ; 60:1, s. 35-41
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Tidskriftsartikel (refereegranskat)abstract
- We have previously shown that tonsil tissue both from children with tonsillar hypertrophy and recurrent tonsillitis is colonized and invaded by <i>Haemophilus influenzae </i>and <i>Streptococcus pyogenes </i>group A. In order to evaluate if these bacteria are involved in the immunopathogenesis of these two conditions, tonsillar cells from both groups were stimulated in vitro with intact, heat-inactivated <i>H. influenzae</i> or <i>S. pyogenes</i> A. The immunoreactivity was evaluated by assessing the induction of cytokine production (IL-1α, IL-1β, TNF-α, IL-6, IL-8, IL-2, IFN-γ, IL-4, TNF-β and IL-10), which was detected at the single-cell level. All cytokines studied except IL-4 were induced in both groups after stimulation with <i>H. influenzae </i>or <i>S. pyogenes </i>A. The dominating cytokines were IL-1β, IFN-γ and TNF-β. No major differences in the cytokine pattern or number of cytokine-producing cells were noticed between the two patient cohorts after <i>H. influenzae </i>stimulation. Activation by <i>S. pyogenes </i>A bacteria gave rise to higher frequencies of IFN-γ- and TNF-β-synthesizing cells in the recurrent tonsillitis group. The incidence of CD4-, CD8-positive T cells and CD40-positive B cells was comparable between the two groups while the MAC-387-positive macrophages were significantly higher in the recurrent tonsillitis groups. In conclusion, a Th<sub>1</sub> type of cytokine response was found in both groups following stimulation with <i>H. influenzae </i>or <i>S. pyogenes </i>A.
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| 16. |
- Agren, P., et al.
(författare)
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Hysteretic current-voltage characteristics and Coulomb blockade in 1D-arrays of Josephson junctions
- 2000
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Ingår i: Physica. B, Condensed matter. - 0921-4526 .- 1873-2135. ; 280:04-jan, s. 414-415
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Tidskriftsartikel (refereegranskat)abstract
- The IV characteristics (IVC) of 1D-arrays of small capacitance Josephson junctions with E-C similar to E-J have been measured. The IVC show Coulomb blockade of Cooper pair tunneling and exhibit a pronounced hysteresis which appears to be dual to the well-known resistively shunted junction behavior of ordinary Josephson junctions. A dual serially resistive junction model is used to qualitatively explain the measured data.
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| 17. |
- Agren, P., et al.
(författare)
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Kinetic inductance and Coulomb blockade in one dimensional Josephson junction arrays
- 2001
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Ingår i: Journal of Low Temperature Physics. - 0022-2291 .- 1573-7357. ; 124:02-jan, s. 291-304
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Tidskriftsartikel (refereegranskat)abstract
- One dimensional Josephson junction arrays have been fabricated and current-voltage characteristics (IVC) have been measured at cryogenic temperatures. The arrays were fabricated in a SQUID-geometry which allowed an in. situ tuning of thc Josephson energy by application of a magnetic field. The IVC of thc arrays shows a clear Coulomb blockade state. In the Coulomb blockade regime the IVC are hysteretic, The array is modeled using a Serial resistive-inductive-junction model which is able to qualitatively explain the IVC. In this model an inductance of the order of 0.1-10 mH per Junction is needed to account for the hysteresis. Kinetic inductance. stemming from the inertia of the Cooper pairs. gives the correct order of magnitude. The problem of self-heating is also discussed as an alternative explanation of the hysteresis.
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| 27. |
- Engelmark, O., et al.
(författare)
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Ecological effects and management aspects of an exotic tree species : the case of lodgepole pine in Sweden
- 2001
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Ingår i: Forest Ecology and Management. - 0378-1127 .- 1872-7042. ; 141:02-jan, s. 3-13
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Tidskriftsartikel (refereegranskat)abstract
- The North American tree Pinus contorta var, latifolia was experimentally introduced in Sweden already in the 1920s, and has been used in Swedish forestry on a large scale since the 1970s. These plantations now cover 565,000 ha, mainly in the northern area. In this paper we summarize and discuss existing ecological knowledge of this species introduction. With regard to longterm sustainability we suggest management means to minimize harmful effects of the introduction on ecosystems. These include aspects of self dispersal, pests, ecosystem and landscape structures, and also ecological processes and biodiversity. We also focus on observed and possible interactions in the ecosystems. As Pinus contorta seeds are disseminated and trees regenerated outside initial plantations, this may have future bearings on biodiversity. We suggest a strategy which takes account of the uncertainty in predicting future ecological effects. The strategy includes areal restrictions and zones without Pinus contorta, but also to set up a monitoring program. Observations of adverse effects from the plantations would then give the possibility to adjust P. contorta management.
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| 28. |
- Gonzalez, CA, et al.
(författare)
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Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- 2003
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136. ; 107:4, s. 629-634
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Tidskriftsartikel (refereegranskat)abstract
- Smoking has recently been recognised as causally associated with the development of gastric cancer (GC). However, evidence on the effect by sex, duration and intensity of smoking, anatomic subsite and cessation of smoking is limited. Our objective was to assess the relation between tobacco use and GC incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC). We studied data from 521,468 individuals recruited from 10 European countries taking part in the EPIC study. Participants completed lifestyle questionnaires that included questions on lifetime consumption of tobacco and diet in 1991-1998. Participants were followed until September 2002, and during that period 305 cases of stomach cancer were identified. After exclusions, 274 were eligible for the analysis, using the Cox proportional hazard model. After adjustment for educational level, consumption of fresh fruit, vegetables and preserved meat, alcohol intake and body mass index (BMI), there was a significant association between cigarette smoking and gastric cancer risk: the hazard ratio (HR) for ever smokers was 1.45 (95% confidence interval [CI] = 1.08-1.94). The HR of current cigarette smoking was 1.73 (95% CI = 1.06-2.83) in males and 1.87 (95% CI = 1.12-3.12) in females. Hazard ratios increased with intensity and duration of cigarette smoked. A significant decrease of risk was observed after 10 years of quitting smoking. A preliminary analysis of 121 cases with identified anatomic site showed that current cigarette smokers had a higher HR of GC in the cardia (HR = 4.10) than in the distal part of the stomach (HR = 1.94). In this cohort, 17.6 % (95% CI = 10.5-29.5 %) of GC cases may be attributable to smoking. Findings from this large study support the causal relation between smoking and gastric cancer in this European population. Stomach cancer should be added to the burden of diseases caused by smoking. (C) 2003 Wiley-Liss, Inc.
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| 29. |
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| 30. |
- Gunnelin, K, et al.
(författare)
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Assigning x-ray absorption spectra by means of soft-x-ray emission spectroscopy
- 1998
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Ingår i: PHYSICAL REVIEW A. - : AMERICAN PHYSICAL SOC. - 1050-2947. ; 57:2, s. 864-872
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The possibility to symmetry assign x-ray absorption spectra using x-ray emission spectroscopy is demonstrated. The oxygen K spectra of CO2 are used to illustrate the possibility to assign core excitations through excitation-energy and angular dependence o
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| 31. |
- Gunnelin, K, et al.
(författare)
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Bond-length-dependent core hole localization observed in simple hydrocarbons
- 1999
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Ingår i: PHYSICAL REVIEW LETTERS. - : AMERICAN PHYSICAL SOC. - 0031-9007. ; 83:7, s. 1315-1318
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Soft x-ray-emission spectroscopy is applied to measure the amount of dynamic symmetry breaking in core-excited acetylene, ethylene, and ethane. Large variations are observed between the molecules and are rationalized in terms of the different C-C bond len
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| 32. |
- Haviland, David B., et al.
(författare)
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Quantum phase transition in one-dimensional Josephson junction arrays
- 2001
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Ingår i: Physica. C, Superconductivity. - 0921-4534 .- 1873-2143. ; 352:04-jan, s. 55-60
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Tidskriftsartikel (refereegranskat)abstract
- We describe experiments on one-dimensional arrays of small capacitance Josephson junctions which show how the Coulomb blockade of Cooper pair tunneling is influenced by changing the Josephson coupling energy in situ with an externally applied magnetic flux. We show how the zero bias resistance of the array is affected by the length of the array, and we use the length scaling of this resistance to infer that a quantum phase transition occurs as the Josephson coupling energy is changed. The data are qualitatively analyzed in terms of a theoretical model of the quantum phase transition which uses a mapping to the two-dimensional XY model.
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| 33. |
- Haviland, David B., et al.
(författare)
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Superconducting and insulating behavior in one-dimensional Josephson junction arrays
- 2000
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Ingår i: Journal of Low Temperature Physics. - 0022-2291 .- 1573-7357. ; 118:06-maj, s. 733-749
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Tidskriftsartikel (refereegranskat)abstract
- Experiments on one-dimensional small capacitance Josephson Junction arrays are described. The arrays have a junction capacitance that is much larger than the stray capacitance of the electrodes, which we argue is important for observation of Coulomb blockade. The Josephson energy can be tuned in situ and an evolution from Josephson-like to Coulomb blockade behavior is observed. This evolution can be described as a superconducting to insulating, quantum phase transition. In the Coulomb blockade state, hysteretic current-voltage characteristics are described by a dynamic model which is dual to the resistively shunted junction model of classical Josephson junctions.
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| 34. |
- Henriksson, K M, et al.
(författare)
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Development of hypertension over 6 years in a birth cohort of young middle-aged men: the Cardiovascular Risk Factor Study in southern Sweden (CRISS).
- 2002
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Ingår i: Journal of Internal Medicine. - : Wiley. - 1365-2796 .- 0954-6820. ; 252:1, s. 21-26
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To explore the development of hypertension (HT) in a cohort of young middle-aged men. DESIGN: Prospective birth-cohort study of men surveyed over 6 years. SETTING: Helsingborg County Hospital, Sweden, 1990-97. SUBJECTS: A total of 628 men born in 1953-54, all surveyed at 37, 40 and 43 years of age. MAIN OUTCOME MEASURES: Systolic blood pressure (SBP), diastolic blood pressure (DBP), S-cholesterol, body mass index (BMI), alcohol consumption, ethnicity. HT was defined as SBP > or = 140 mmHg and/or DBP > or = 90 mmHg, or ongoing treatment. Using SBP < 130 mmHg and DBP < 85 mmHg as reference, the odds of conversion to HT in men with high normal blood pressure (BP) (SBP 130-139 mmHg and DBP 85-89 mmHg) was investigated. RESULTS: At age 37, 243 men (39%) had reference BP, 167 (26%) had high normal BP and 218 (35%) were hypertensive. Corresponding numbers at age 40 were 265 (42%), 166 (27%) and 197 (31%); and at age 43, 180 (29%), 142 (22%) and 306 (49%), respectively. High normal BP at baseline was associated with the development of HT both at age 40 (odds ratio (OR)=2.45 confidence interval (CI): 1.42-4.22) and at age 43 (OR=2.46, CI: 1.59-3.80), independent of other cardiovascular disease risk factors and ethnicity. The progression to HT was predicted also by S-cholesterol, alcohol consumption, BMI and weight gain. CONCLUSIONS: Over a short-term period, a substantial proportion of young middle-aged men with high normal BP develop HT with overweight and alcohol consumption as important determinants. These findings have implications for the prevention, screening and medical care of HT in this target population.
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| 35. |
- Hyvonen, R., et al.
(författare)
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The likely impact of elevated [CO2], nitrogen deposition, increased temperature and management on carbon sequestration in temperate and boreal forest ecosystems: a literature review
- 2007
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Ingår i: New Phytologist. - Cambridge : Wiley. - 0028-646X .- 1469-8137. ; 173:3, s. 463-480
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Forskningsöversikt (refereegranskat)abstract
- Temperate and boreal forest ecosystems contain a large part of the carbon stored on land, in the form of both biomass and soil organic matter. Increasing atmospheric [CO2], increasing temperature, elevated nitrogen deposition and intensified management will change this C store. Well documented single-factor responses of net primary production are: higher photosynthetic rate (the main [CO2] response); increasing length of growing season (the main temperature response); and higher leaf-area index (the main N deposition and partly [CO2] response). Soil organic matter will increase with increasing litter input, although priming may decrease the soil C stock initially, but litter quality effects should be minimal (response to [CO2], N deposition, and temperature); will decrease because of increasing temperature; and will increase because of retardation of decomposition with N deposition, although the rate of decomposition of high-quality litter can be increased and that of low-quality litter decreased. Single-factor responses can be misleading because of interactions between factors, in particular those between N and other factors, and indirect effects such as increased N availability from temperature-induced decomposition. In the long term the strength of feedbacks, for example the increasing demand for N from increased growth, will dominate over short-term responses to single factors. However, management has considerable potential for controlling the C store.
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| 36. |
- Jansik, B., et al.
(författare)
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Relativistic effects on linear and non-linear polarizabilities of the furan homologues
- 2003
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Ingår i: Journal of Molecular Structure. - 0166-1280. ; 633:2-3, s. 237-246
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Tidskriftsartikel (refereegranskat)abstract
- First principles calculations including relativistic effects are carried out for dipole moments, polarizabilities, first- and second-order hyperpolarizabilities for the series of furan homologues XC4H 4, X = O, S, Se, Te, at three different levels of theory, time-dependent Dirac-Hartree-Fock (DHF), time-dependent Hartree-Fock with a Douglas-Kroll transformed one-component Hamiltonian, and time-dependent Hartree-Fock using effective-core potentials. By comparison with the corresponding non-relativistic results, the influence of relativistic effects on the properties as well as the accuracy of previously reported calculations on these molecules using effective-core potentials for selenium and tellurium can be addressed. The obtained results indicate that relativistic effects can be described with comparable accuracy at all three employed levels, and that non-scalar effects, which are explicitly treated only at the time-dependent DHF level, are of minor importance. Frequency dispersion and relativity are found to be additive at the single-determinant level. We find that relativistic effects cannot make up for the earlier identified mismatch between theory and experiment for the non-linear polarizabilities of the heavier homologues. A Bishop-Kirtman analysis of vibrational effects indicates that the same can be said about these. © 2003 Elsevier B.V. All rights reserved.
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| 40. |
- Mirastschijski, U, et al.
(författare)
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Effect of a matrix metalloproteinase activity and TNF-alpha converting enzyme inhibitor on intra-abdominal adhesions.
- 2005
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Ingår i: European Surgical Research. - : S. Karger AG. - 0014-312X .- 1421-9921. ; 37:1, s. 68-75
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Formation of intra-abdominal adhesions depends, in part, on the activity of serine proteinases. Matrix metalloproteinases (MMP) are required for epithelialization of skin wounds but their involvement in mesothelialization of peritoneal wounds and in adhesion pathogenesis is not known. Early tumor necrosis factor-alpha (TNF-alpha) levels have been proposed to reflect propensity to adhesion formation. OBJECTIVE: The impact of MMP activity and secreted TNF-alpha on peritoneal adhesion formation and healing was investigated through systemic administration of the synthetic broad-spectrum MMP and TNF-alpha-converting enzyme (TACE) inhibitor GM 6001. METHODS: Female Sprague-Dawley rats of 4-6 weeks of age were injected subcutaneously daily with GM 6001 100 mg/kg (n = 12) or vehicle (n = 10) starting two days before surgery. In each rat, two standardized peritoneal wounds, 20 mm x 5 mm, were made. One peritoneal wound was sutured whereas the contralateral wound healed by secondary intention. Adhesion formation and peritoneal healing, cell proliferation, and hydroxyproline concentrations were evaluated on postoperative day 7. RESULTS: Total serum TNF-alpha levels increased in vehicle-treated rats (p = 0.019) while GM 6001 treatment effectively prevented the rise in the postoperative phase (p < 0.001). No significant differences were observed in the extent of adhesion formation (p = 0.67) between control (65.0%) and GM 6001-treated (61.5%) animals, or peritoneal wound healing or cell proliferation. Hydroxyproline levels increased in the wounds (p = 0.014) but were not different between the two groups (p = 0.14). CONCLUSIONS: Lack of a striking effect of the MMP and TACE antagonist GM 6001 on postoperative adhesions suggests that MMP activity and TNF-alpha might not be major adhesiogenic factors.
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| 49. |
- Skytt, P, et al.
(författare)
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Quenching of symmetry breaking in resonant inelastic X-ray scattering by detuned excitation
- 1996
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Ingår i: PHYSICAL REVIEW LETTERS. - : AMER INST PHYSICS. - 0031-9007. ; 77:25, s. 5035-5038
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Observations made in oxygen K emission of CO2 show that the symmetry selective character of resonant x-ray emission is excitation energy dependent. Electronically dipole forbidden O K emission lines are observed for excitation at the O 1s --> pi* resonanc
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| 50. |
- Skytt, P, et al.
(författare)
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Role of screening and angular distributions in resonant x-ray emission of CO
- 1997
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Ingår i: PHYSICAL REVIEW A. - : AMER INST PHYSICS. - 1050-2947. ; 55:1, s. 134-145
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Resonantly excited carbon and oxygen x-ray-emission spectra of gaseous carbon monoxide are presented. Emission spectra obtained with selective excitation to the pi* valence orbital and to various Rydberg levels are compared to satellite-free nonresonant s
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