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- 2019
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Cook, D. O., et al.
(författare)
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Star cluster catalogues for the LEGUS dwarf galaxies
- 2019
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 484:4, s. 4897-4919
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Tidskriftsartikel (refereegranskat)abstract
- We present the star cluster catalogues for 17 dwarf and irregular galaxies in the HST Treasury Program 'Legacy ExtraGalactic UV Survey' (LEGUS). Cluster identification and photometry in this sub-sample are similar to that of the entire LEGUS sample, but special methods were developed to provide robust catalogues with accurate fluxes due to low cluster statistics. The colours and ages are largely consistent for two widely used aperture corrections, but a significant fraction of the clusters are more compact than the average training cluster. However, the ensemble luminosity, mass, and age distributions are consistent suggesting that the systematics between the two methods are less than the random errors. When compared with the clusters from previous dwarf galaxy samples, we find that the LEGUS catalogues are more complete and provide more accurate total fluxes. Combining all clusters into a composite dwarf galaxy, we find that the luminosity and mass functions can be described by a power law with the canonical index of -2 independent of age and global SFR binning. The age distribution declines as a power law, with an index of approximate to -0.80 +/- 0.15, independent of cluster mass and global SFR binning. This decline of clusters is dominated by cluster disruption since the combined star formation histories and integrated-light SFRs are both approximately constant over the last few hundred Myr. Finally, we find little evidence for an upper-mass cut-off (< 2 sigma) in the composite cluster mass function, and can rule out a truncation mass below approximate to 10(4.5)M(circle dot) but cannot rule out the existence of a truncation at higher masses.
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| 9. |
- van der Harst, Pim, et al.
(författare)
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Seventy-five genetic loci influencing the human red blood cell
- 2012
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 492:7429, s. 369-375
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Tidskriftsartikel (refereegranskat)abstract
- Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10(-8), which together explain 4-9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in Mus musculus or Drosophila melanogaster. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.
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| 10. |
- Adamo, Angela, et al.
(författare)
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Legacy ExtraGalactic UV Survey with The Hubble Space Telescope : Stellar Cluster Catalogs and First Insights Into Cluster Formation and Evolution in NGC 628
- 2017
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Ingår i: Astrophysical Journal. - : IOP PUBLISHING LTD. - 0004-637X .- 1538-4357. ; 841:2
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Tidskriftsartikel (refereegranskat)abstract
- We report the large effort that is producing comprehensive high-level young star cluster (YSC) catalogs for a significant fraction of galaxies observed with the Legacy ExtraGalactic UV Survey (LEGUS) Hubble treasury program. We present the methodology developed to extract cluster positions, verify their genuine nature, produce multiband photometry (from NUV to NIR), and derive their physical properties via spectral energy distribution fitting analyses. We use the nearby spiral galaxy NGC 628 as a test case for demonstrating the impact that LEGUS will have on our understanding of the formation and evolution of YSCs and compact stellar associations within their host galaxy. Our analysis of the cluster luminosity function from the UV to the NIR finds a steepening at the bright end and at all wavelengths suggesting a dearth of luminous clusters. The cluster mass function of NGC 628 is consistent with a power-law distribution of slopes similar to-2 and a truncation of a few times 10(5) M-circle dot. After their formation, YSCs and compact associations follow different evolutionary paths. YSCs survive for a longer time frame, confirming their being potentially bound systems. Associations disappear on timescales comparable to hierarchically organized star-forming regions, suggesting that they are expanding systems. We find massindependent cluster disruption in the inner region of NGC 628, while in the outer part of the galaxy there is little or no disruption. We observe faster disruption rates for low mass (<= 10(4) M-circle dot) clusters, suggesting that a massdependent component is necessary to fully describe the YSC disruption process in NGC 628.
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| 11. |
- Adamo, A., et al.
(författare)
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Revealing a ring-like cluster complex in a tidal tail of the starburst galaxy NGC 2146
- 2012
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 426:2, s. 1185-1194
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Tidskriftsartikel (refereegranskat)abstract
- We report the discovery of a ring-like cluster complex in the starburst galaxy NGC?2146. The Ruby Ring, so named due to its appearance, shows a clear ring-like distribution of star clusters around a central object. It is located in one of the tidal streams that surround the galaxy. NGC?2146 is part of the Snapshot Hubble U-band Cluster Survey (SHUCS). The WFC3/F336W data have added critical information to the available archival Hubble Space Telescope imaging set of NGC?2146, allowing us to determine ages, masses and extinctions of the clusters in the Ruby Ring. These properties have then been used to investigate the formation of this extraordinary system. We find evidence of a spatial and temporal correlation between the central cluster and the clusters in the ring. The latter are about 4?Myr younger than the central cluster, which has an age of 7?Myr. This result is supported by the Ha emission which is strongly coincident with the ring, and weaker at the position of the central cluster. From the derived total Ha luminosity of the system, we constrain the star formation rate density to be quite high (SSFR = 0.47?M??yr-1?kpc-2). The Ruby Ring is the product of an intense and localized burst of star formation, similar to the extended cluster complexes observed in M?51 and the Antennae, but more impressive because it is quite isolated. The central cluster contains only 5 per cent of the total stellar mass in the clusters that are determined within the complex. The ring-like morphology, the age spread and the mass ratio support a triggering formation scenario for this complex. We discuss the formation of the Ruby Ring in a collect and collapse framework. The predictions made by this model agree quite well with the estimated bubble radius and expansion velocity produced by the feedback from the central cluster, making the Ruby Ring an interesting case of triggered star formation.
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| 12. |
- Calzetti, D., et al.
(författare)
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LEGACY EXTRAGALACTIC UV SURVEY (LEGUS) WITH THE HUBBLE SPACE TELESCOPE. I. SURVEY DESCRIPTION
- 2015
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Ingår i: Astronomical Journal. - : American Astronomical Society. - 0004-6256 .- 1538-3881. ; 149:2
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Tidskriftsartikel (refereegranskat)abstract
- The Legacy ExtraGalactic UV Survey (LEGUS) is a Cycle 21 Treasury program on the Hubble Space Telescope aimed at the investigation of star formation and its relation with galactic environment in nearby galaxies, from the scales of individual stars to those of similar to kiloparsec-size clustered structures. Five-band imaging from the nearultraviolet to the I band with the Wide-Field Camera 3 (WFC3), plus parallel optical imaging with the Advanced Camera for Surveys (ACS), is being collected for selected pointings of 50 galaxies within the local 12 Mpc. The filters used for the observations with the WFC3 are F275W(lambda 2704 angstrom), F336W(lambda 3355 angstrom), F438W(lambda 4325 angstrom), F555W(lambda 5308 angstrom), and F814W(lambda 8024 angstrom); the parallel observations with the ACS use the filters F435W (lambda 4328 angstrom), F606W(lambda 5921 angstrom), and F814W(lambda 8057 angstrom). The multiband images are yielding accurate recent (less than or similar to 50 Myr) star formation histories from resolved massive stars and the extinction-corrected ages and masses of star clusters and associations. The extensive inventories of massive stars and clustered systems will be used to investigate the spatial and temporal evolution of star formation within galaxies. This will, in turn, inform theories of galaxy evolution and improve the understanding of the physical underpinning of the gas-star formation relation and the nature of star formation at high redshift. This paper describes the survey, its goals and observational strategy, and the initial scientific results. Because LEGUS will provide a reference survey and a foundation for future observations with the James Webb Space Telescope and with ALMA, a large number of data products are planned for delivery to the community.
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| 13. |
- Kahre, L., et al.
(författare)
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Extinction Maps and Dust-to-gas Ratios in Nearby Galaxies with LEGUS
- 2018
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 855:2
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of the dust-to-gas ratios in five nearby galaxies: NGC 628 (M74), NGC 6503, NGC 7793, UGC 5139 (Holmberg I), and UGC 4305 (Holmberg II). Using Hubble Space Telescope broadband WFC3/UVIS UV and optical images from the Treasury program Legacy ExtraGalactic UV Survey (LEGUS) combined with archival HST/Advanced Camera for Surveys data, we correct thousands of individual stars for extinction across these five galaxies using an isochrone-matching (reddening-free Q) method. We generate extinction maps for each galaxy from the individual stellar extinctions using both adaptive and fixed resolution techniques and correlate these maps with neutral H I and CO gas maps from the literature, including the H I Nearby Galaxy Survey and the HERA CO-Line Extragalactic Survey. We calculate dust-to-gas ratios and investigate variations in the dust-to-gas ratio with galaxy metallicity. We find a power-law relationship between dust-to-gas ratio and metallicity, consistent with other studies of dust-to-gas ratio compared to metallicity. We find a change in the relation when H-2 is not included. This implies that underestimation of N-H2 in low-metallicity dwarfs from a too-low CO-to-H-2 conversion factor X-CO could have produced too low a slope in the derived relationship between dust-to-gas ratio and metallicity. We also compare our extinctions to those derived from fitting the spectral energy distribution (SED) using the Bayesian Extinction and Stellar Tool for NGC 7793 and find systematically lower extinctions from SED fitting as compared to isochrone matching.
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| 14. |
- Konstantopoulos, I. S., et al.
(författare)
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THE SNAPSHOT HUBBLE U-BAND CLUSTER SURVEY (SHUCS). I. SURVEY DESCRIPTION AND FIRST APPLICATION TO THE MIXED STAR CLUSTER POPULATION OF NGC 4041
- 2013
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Ingår i: Astronomical Journal. - : American Astronomical Society. - 0004-6256 .- 1538-3881. ; 145:5, s. 137-
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Tidskriftsartikel (refereegranskat)abstract
- We present the Snapshot Hubble U-band Cluster Survey (SHUCS), a project aimed at characterizing the star cluster populations of 10 nearby galaxies (d < 23 Mpc, half within approximate to 12 Mpc) through new F336W (U-band equivalent) imaging from Wide Field Camera 3, and archival BVI-equivalent data with the Hubble Space Telescope. Completing the UBVI baseline reduces the age-extinction degeneracy of optical colors, thus enabling the measurement of reliable ages and masses for the thousands of clusters covered by our survey. The sample consists chiefly of face-on spiral galaxies at low inclination, in various degrees of isolation (isolated, in group, merging), and includes two active galactic nucleus hosts. This first paper outlines the survey itself, the observational datasets, the analysis methods, and presents a proof-of-concept study of the large-scale properties and star cluster population of NGC 4041, a massive SAbc galaxy at a distance of approximate to 23 Mpc, and part of a small grouping of six giant members. We resolve two structural components with distinct stellar populations, a morphology more akin to merging and interacting systems. We also find strong evidence of a truncated, Schechter-type mass function, and a similarly segmented luminosity function. These results indicate that binning must erase much of the substructure present in the mass and luminosity functions, and might account for the conflicting reports on the intrinsic shape of these functions in the literature. We also note a tidal feature in the outskirts of the galaxy in Galaxy Evolution Explorer UV imaging, and follow it up with a comprehensive multi-wavelength study of NGC 4041 and its parent group. We deduce a minor merger as a likely cause of its segmented structure and the observed pattern of a radially decreasing star formation rate. We propose that combining the study of star cluster populations with broadband metrics is not only advantageous, but often easily achievable thorough archival datasets.
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| 15. |
- Rousseau-Nepton, L., et al.
(författare)
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SIGNALS : I. Survey description
- 2019
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 489:4, s. 5530-5546
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Tidskriftsartikel (refereegranskat)abstract
- SIGNALS, the Star formation, Ionized Gas, and Nebular Abundances Legacy Survey, is a large observing programme designed to investigate massive star formation and HII regions in a sample of local extended galaxies. The programme will use the imaging Fourier transform spectrograph SITELLE at the Canada-France-Hawaii Telescope. Over 355 h (54.7 nights) have been allocated beginning in fall 2018 for eight consecutive semesters. Once completed, SIGNALS will provide a statistically reliable laboratory to investigate massive star formation, including over 50 000 resolved HII regions: the largest, most complete, and homogeneous data base of spectroscopically and spatially resolved extragalactic HII regions ever assembled. For each field observed, three datacubes covering the spectral bands of the filters SN1 (363386 nm), SN2 (482-513 nm), and SN3 (647-685 nm) are gathered. The spectral resolution selected for each spectral band is 1000, 1000, and 5000, respectively. As defined, the project sample will facilitate the study of small-scale nebular physics and many other phenomena linked to star formation at a mean spatial resolution of similar to 20 pc. This survey also has considerable legacy value for additional topics, including planetary nebulae, diffuse ionized gas, and supernova remnants. The purpose of this paper is to present a general outlook of the survey, notably the observing strategy, galaxy sample, and science requirements.
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| 16. |
- Sabbi, E., et al.
(författare)
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The Resolved Stellar Populations in the LEGUS Galaxies
- 2018
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Ingår i: Astrophysical Journal Supplement Series. - : American Astronomical Society. - 0067-0049 .- 1538-4365. ; 235:1
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Tidskriftsartikel (refereegranskat)abstract
- The Legacy ExtraGalactic UV Survey (LEGUS) is a multiwavelength Cycle 21 Treasury program on the Hubble Space Telescope. It studied 50 nearby star-forming galaxies in 5 bands from the near-UV to the I-band, combining new Wide Field Camera 3 observations with archival Advanced Camera for Surveys data. LEGUS was designed to investigate how star formation occurs and develops on both small and large scales, and how it relates to the galactic environments. In this paper we present the photometric catalogs for all the apparently single stars identified in the 50 LEGUS galaxies. Photometric catalogs and mosaicked images for all filters are available for download. We present optical and near-UV color-magnitude diagrams for all the galaxies. For each galaxy we derived the distance from the tip of the red giant branch. We then used the NUV color-magnitude diagrams to identify stars more massive than 14 Me, and compared their number with the number of massive stars expected from the GALEX FUV luminosity. Our analysis shows that the fraction of massive stars forming in star clusters and stellar associations is about constant with the star formation rate. This lack of a relation suggests that the timescale for evaporation of unbound structures is comparable or longer than 10 Myr. At low star formation rates this translates to an excess of mass in clustered environments as compared to model predictions of cluster evolution, suggesting that a significant fraction of stars form in unbound systems.
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| 17. |
- Calzetti, D., et al.
(författare)
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THE BRIGHTEST YOUNG STAR CLUSTERS IN NGC 5253
- 2015
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 811:2
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Tidskriftsartikel (refereegranskat)abstract
- The nearby dwarf starburst galaxy NGC 5253 hosts a number of young, massive star clusters, the two youngest of which are centrally concentrated and surrounded by thermal radio emission (the radio nebula). To investigate the role of these clusters in the starburst energetics, we combine new and archival Hubble Space Telescope images of NGC 5253 with wavelength coverage from 1500 angstrom 1.9 mu m in 13 filters. These include H alpha, P beta, and P alpha, and the imaging from the Hubble Treasury Program LEGUS (Legacy Extragalactic UV Survey). The extraordinarily well-sampled spectral energy distributions enable modeling with unprecedented accuracy the ages, masses, and extinctions of the nine optically brightest clusters (M-V < -8.8) and the two young radio nebula clusters. The clusters have ages similar to 1-15 Myr and masses similar to 1 x 10(4)-2.5 x 10(5) M-circle dot. The clusters' spatial location and ages indicate that star formation has become more concentrated toward the radio nebula over the last similar to 15 Myr. The most massive cluster is in the radio nebula; with a mass similar to 2.5 x 10(5) M-circle dot and an age similar to 1 Myr, it is 2-4 times less massive and younger than previously estimated. It is within a dust cloud with AV similar to 50 mag, and shows a clear near-IR excess, likely from hot dust. The second radio nebula cluster is also similar to 1 Myr old, confirming the extreme youth of the starburst region. These two clusters account for about half of the ionizing photon rate in the radio nebula, and will eventually supply about 2/3 of the mechanical energy in present-day shocks. Additional sources are required to supply the remaining ionizing radiation, and may include very massive stars.
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| 18. |
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| 19. |
- Adamo, Angela, et al.
(författare)
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Star cluster formation in the most extreme environments: Insights from the HiPEEC survey
- 2020
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 499:3, s. 3267-3294
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Tidskriftsartikel (refereegranskat)abstract
- We present the Hubble imaging Probe of Extreme Environments and Clusters (HiPEEC) survey. We fit HST NUV to NIR broad-band and H α fluxes to derive star cluster ages, masses, and extinctions and determine the star formation rate (SFR) of six merging galaxies. These systems are excellent laboratories to trace cluster formation under extreme gas physical conditions, rare in the local Universe, but typical for star-forming galaxies at cosmic noon. We detect clusters with ages of 1-500 Myr and masses that exceed 107 M☉. The recent cluster formation history and their distribution within the host galaxies suggest that systems such as NGC 34, NGC 1614, and NGC 4194 are close to their final coalescing phase, while NGC 3256, NGC 3690, and NGC 6052 are at an earlier/intermediate stage. A Bayesian analysis of the cluster mass function in the age interval 1-100 Myr provides strong evidence in four of the six galaxies that an exponentially truncated power law better describes the observed mass distributions. For two galaxies, the fits are inconclusive due to low number statistics. We determine power-law slopes β ∼ −1.5 to −2.0 and truncation masses, Mc, between 106 and a few times 107 M☉, among the highest values reported in the literature. Advanced mergers have higher Mc than early/intermediate merger stage galaxies, suggesting rapid changes in the dense gas conditions during the merger. We compare the total stellar mass in clusters to the SFR of the galaxy, finding that these systems are among the most efficient environments to form star clusters in the local Universe.
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| 20. |
- Bastian, N., et al.
(författare)
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Evidence for environmentally dependent cluster disruption in M83
- 2011
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966 .- 1745-3925. ; 417:1, s. l6-L10
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Tidskriftsartikel (refereegranskat)abstract
- Using multiwavelength imaging from the Wide Field Camera 3 on the Hubble Space Telescope we study the stellar cluster populations of two adjacent fields in the nearby face-on spiral galaxy, M83. The observations cover the galactic centre and reach out to similar to 6 kpc, thereby spanning a large range of environmental conditions, ideal for testing empirical laws of cluster disruption. The clusters are selected by visual inspection to be centrally concentrated, symmetric and resolved on the images. We find that a large fraction of objects detected by automated algorithms (e. g. SEXTRACTOR or DAOFIND) are not clusters, but rather are associations. These are likely to disperse into the field on time-scales of tens of Myr due to their lower stellar densities and not due to gas expulsion (i.e. they were never gravitationally bound). We split the sample into two discrete fields (inner and outer regions of the galaxy) and search for evidence of environmentally dependent cluster disruption. Colour-colour diagrams of the clusters, when compared to simple stellar population models, already indicate that a much larger fraction of the clusters in the outer field are older by tens of Myr than in the inner field. This impression is quantified by estimating each cluster's properties (age, mass and extinction) and comparing the age/mass distributions between the two fields. Our results are inconsistent with 'universal' age and mass distributions of clusters, and instead show that the ambient environment strongly affects the observed populations.
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| 21. |
- Bastian, N., et al.
(författare)
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Stellar clusters in M83 : formation, evolution, disruption and the influence of the environment
- 2012
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 1365-2966 .- 0035-8711. ; 419:3, s. 2606-2622
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Tidskriftsartikel (refereegranskat)abstract
- We study the stellar cluster population in two adjacent fields in the nearby, face-on spiral galaxy M83 using multiwavelength Wide Field Camera 3/Hubble Space Telescope imaging. After automatic detection procedures, the clusters are selected through visual inspection to be centrally concentrated, symmetric, and resolved on the images, which allows us to differentiate between clusters and likely unbound associations. We compare our sample with previous studies and show that the differences between the catalogues are largely due to the inclusion of a large numbers of diffuse associations within previous catalogues as well as the inclusion of the central starburst region, where the completeness limit is significantly worse than in the surrounding regions. We derive the size distribution of the clusters, which is well described by a lognormal distribution with a peak at ˜2.5 pc, and find evidence for an expansion in the half-light radius of clusters with age. The luminosity function of the clusters is well approximated by a power law with an index of -2 over most of the observed range; however, a steepening is seen at MV=-9.3 and -8.8 in the inner and outer fields, respectively. Additionally, we show that the cluster population is inconsistent with a pure power-law mass distribution, but instead exhibits a truncation at the high-mass end. If described as a Schechter function, the characteristic mass is 1.6 × 105 and 0.5 × 105 M&sun; for the inner and outer fields, respectively, in agreement with previous estimates of other cluster populations in spiral galaxies. Comparing the predictions of the mass-independent disruption (MID) and mass-dependent disruption (MDD) scenarios with the observed distributions, we find that both models can accurately fit the data. However, for the MID case, the fraction of clusters destroyed (or mass lost) per decade in age is dependent on the environment; hence, the age and mass distributions of clusters are not universal. In the MDD case, the disruption time-scale scales with galactocentric distance (being longer in the outer regions of the galaxy) in agreement with analytic and numerical predictions. Finally, we discuss the implications of our results on other extragalactic surveys, focusing on the fraction of stars that form in clusters and the need (or lack thereof) for infant mortality.
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| 22. |
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| 23. |
- Grasha, K., et al.
(författare)
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The spatial relation between young star clusters and molecular clouds in M51 with LEGUS
- 2019
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 483:4, s. 4707-4723
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Tidskriftsartikel (refereegranskat)abstract
- We present a study correlating the spatial locations of young star clusters with those of molecular clouds in NGC 5194, in order to investigate the time-scale over which clusters separate from their birth clouds. The star cluster catalogues are from the Legacy ExtraGalactic UV Survey (LEGUS) and the molecular clouds from the Plateau de Bure Interefrometer Arcsecond Whirpool Survey (PAWS). We find that younger star clusters are spatially closer to molecular clouds than older star clusters. The median age for clusters associated with clouds is 4 Myr, whereas it is 50 Myr for clusters that are sufficiently separated from a molecular cloud to be considered unassociated. After similar to 6 Myr, the majority of the star clusters lose association with their molecular gas. Younger star clusters are also preferentially located in stellar spiral arms where they are hierarchically distributed in kpc-size regions for 50-100 Myr before dispersing. The youngest star clusters are more strongly clustered, yielding a two-point correlation function with alpha = -0.28 +/- 0.04, than the giant molecular cloud (GMCs) (alpha = -0.09 +/- 0.03) within the same PAWS field. However, the clustering strength of the most massive GMCs, supposedly the progenitors of the young clusters for a star formation efficiency of a few percent, is comparable (alpha = -0.35 +/- 0.05) to that of the clusters. We find a galactocentric dependence for the coherence of star formation, in which clusters located in the inner region of the galaxy reside in smaller star-forming complexes and display more homogeneous distributions than clusters further from the centre. This result suggests a correlation between the survival of a cluster complex and its environment.
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| 24. |
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| 25. |
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| 26. |
- Messa, Matteo, et al.
(författare)
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The young star cluster population of M51 with LEGUS - I. A comprehensive study of cluster formation and evolution
- 2018
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 473:1, s. 996-1018
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Tidskriftsartikel (refereegranskat)abstract
- Recently acquired WFC3 UV (F275W and F336W) imaging mosaics under the Legacy Extragalactic UV Survey (LEGUS), combined with archival ACS data of M51, are used to study the young star cluster (YSC) population of this interacting system. Our newly extracted source catalogue contains 2834 cluster candidates, morphologically classified to be compact and uniform in colour, for which ages, masses and extinction are derived. In this first work we study the main properties of the YSC population of the whole galaxy, considering a mass-limited sample. Both luminosity and mass functions follow a power-law shape with slope -2, but at high luminosities and masses a dearth of sources is observed. The analysis of the mass function suggests that it is best fitted by a Schechter function with slope -2 and a truncation mass at 1.00 +/- 0.12 x 10(5) M-circle dot . Through Monte Carlo simulations, we confirm this result and link the shape of the luminosity function to the presence of a truncation in the mass function. A mass limited age function analysis, between 10 and 200 Myr, suggests that the cluster population is undergoing only moderate disruption. We observe little variation in the shape of the mass function at masses above 1 x 10(4) M-circle dot over this age range. The fraction of star formation happening in the form of bound clusters in M51 is similar to 20 per cent in the age range 10-100 Myr and little variation is observed over the whole range from 1 to 200 Myr.
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| 27. |
- O'Seaghdha, Conall M., et al.
(författare)
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Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations
- 2013
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Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 9:9, s. e1003796-
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Tidskriftsartikel (refereegranskat)abstract
- Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in <= 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.
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| 28. |
- Ryon, J. E., et al.
(författare)
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Sizes and shapes of young star cluster light profiles in M83
- 2015
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 452:1, s. 525-539
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Tidskriftsartikel (refereegranskat)abstract
- We measure the radii and two-dimensional light profiles of a large sample of young, massive star clusters in M83 using archival HST/Wide Field Camera 3 (WFC3) imaging of seven adjacent fields. We use GALFIT to fit the two-dimensional light profiles of the clusters, from which we find effective (half-light) radii, core radii, and slopes of the power-law (EFF) profile (eta). We find lognormal distributions of effective radius and core radius, with medians of approximate to 2.5 and approximate to 1.3 pc, respectively. Our results provide strong evidence for a characteristic size of young, massive clusters. The average effective radius and core radius increase somewhat with cluster age. Little to no change in effective radius is observed with increasing galactocentric distance, except perhaps for clusters younger than 100 Myr. We find a shallow correlation between effective radius and mass for the full cluster sample, but a stronger correlation is present for clusters 200-300 Myr in age. Finally, the majority of the clusters are best fit by an EFF model with index eta less than or similar to 3.0. There is no strong evidence for change in. with cluster age, mass, or galactocentric distance. Our results suggest that clusters emerge from early evolution with similar radii and are not strongly affected by the tidal field of M83. Mass-loss due to stellar evolution and/or giant molecular cloud interactions appear to dominate cluster expansion in the age range we study.
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| 29. |
- Ryon, J. E., et al.
(författare)
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THE SNAPSHOT HUBBLE U-BAND CLUSTER SURVEY (SHUCS). II. THE STAR CLUSTER POPULATION OF NGC 2997
- 2014
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Ingår i: Astronomical Journal. - : American Astronomical Society. - 0004-6256 .- 1538-3881. ; 148:2, s. 33-
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Tidskriftsartikel (refereegranskat)abstract
- We study the star cluster population of NGC 2997, a giant spiral galaxy located at 9.5 Mpc and targeted by the Snapshot Hubble U-band Cluster Survey (SHUCS). Combining our U-band imaging from SHUCS with archival BVI imaging from the Hubble Space Telescope, we select a high confidence sample of clusters in the circumnuclear ring and disk through a combination of automatic detection procedures and visual inspection. The cluster luminosity functions in all four filters can be approximated by power laws with indices of -1.7 to -2.3. Some deviations from pure power-law shape are observed, hinting at the presence of a high-mass truncation in the cluster mass function. However, upon inspection of the cluster mass function, we find it is consistent with a pure power law of index -2.2 +/- 0.2 despite a slight bend at similar to 2.5 x 10(4) M-circle dot. No statistically significant truncation is observed. From the cluster age distributions, we find a low rate of disruption(zeta similar to -0.1) in both the disk and circumnuclear ring. Finally, we estimate the cluster formation efficiency (Gamma) over the last 100 Myr in each region, finding 7% +/- 2% for the disk, 12% +/- 4% for the circumnuclear ring, and 10% +/- 3% for the entire UBVI footprint. This study highlights the need for wide-field UBVI coverage of galaxies to study cluster populations in detail, though a small sample of clusters can provide significant insight into the characteristics of the population.
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| 30. |
- Wahl, Simone, et al.
(författare)
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Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
- 2017
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Ingår i: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 541:7635, s. 81-
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Tidskriftsartikel (refereegranskat)abstract
- Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type (2) diabetes, cardiovascular disease and related metabolic and inflammatory disturbances(1,2). Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation(3-6), a key regulator of gene expression and molecular phenotype(7). Here we use epigenome-wide association to show that body mass index (BMI; a key measure of adiposity) is associated with widespread changes in DNA methylation (187 genetic loci with P < 1 x 10(-7), range P = 9.2 x 10(-8) to 6.0 x 10(-46); n = 10,261 samples). Genetic association analyses demonstrate that the alterations in DNA methylation are predominantly the consequence of adiposity, rather than the cause. We find that methylation loci are enriched for functional genomic features in multiple tissues (P < 0.05), and show that sentinel methylation markers identify gene expression signatures at 38 loci (P < 9.0 x 10(-6), range P = 5.5 x 10(-6) to 6.1 x 10(-35), n = 1,785 samples). The methylation loci identify genes involved in lipid and lipoprotein metabolism, substrate transport and inflammatory pathways. Finally, we show that the disturbances in DNA methylation predict future development of type 2 diabetes (relative risk per 1 standard deviation increase in methylation risk score: 2.3 (2.07-2.56); P = 1.1 x 10(-54)). Our results provide new insights into the biologic pathways influenced by adiposity, and may enable development of new strategies for prediction and prevention of type 2 diabetes and other adverse clinical consequences of obesity.
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| 31. |
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| 37. |
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| 38. |
- Chirinos, Julio A., et al.
(författare)
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Reduced Apolipoprotein M and Adverse Outcomes across the Spectrum of Human Heart Failure
- 2020
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Ingår i: Circulation. - 0009-7322. ; , s. 1463-1476
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Tidskriftsartikel (refereegranskat)abstract
- Background: Apo (apolipoprotein) M mediates the physical interaction between high-density lipoprotein (HDL) particles and sphingosine-1-phosphate (S1P). Apo M exerts anti-inflammatory and cardioprotective effects in animal models. Methods: In a subset of PHFS (Penn Heart Failure Study) participants (n=297), we measured apo M by Enzyme-Linked ImmunoSorbent Assay (ELISA). We also measured total S1P by liquid chromatography-mass spectrometry and isolated HDL particles to test the association between apo M and HDL-associated S1P. We confirmed the relationship between apo M and outcomes using modified aptamer-based apo M measurements among 2170 adults in the PHFS and 2 independent cohorts: the Washington University Heart Failure Registry (n=173) and a subset of TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial; n=218). Last, we examined the relationship between apo M and ≈5000 other proteins (SomaScan assay) to identify biological pathways associated with apo M in heart failure. Results: In the PHFS, apo M was inversely associated with the risk of death (standardized hazard ratio, 0.56 [95% CI, 0.51-0.61]; P<0.0001) and the composite of death/ventricular assist device implantation/heart transplantation (standardized hazard ratio, 0.62 [95% CI, 0.58-0.67]; P<0.0001). This relationship was independent of HDL cholesterol or apo AI levels. Apo M remained associated with death (hazard ratio, 0.78 [95% CI, 0.69-0.88]; P<0.0001) and the composite of death/ventricular assist device/heart transplantation (hazard ratio, 0.85 [95% CI, 0.76-0.94]; P=0.001) in models that adjusted for multiple confounders. This association was present in both heart failure with reduced and preserved ejection fraction and was replicated in the Washington University cohort and a cohort with heart failure with preserved ejection fraction only (TOPCAT). The S1P and apo M content of isolated HDL particles strongly correlated (R=0.81, P<0.0001). The top canonical pathways associated with apo M were inflammation (negative association), the coagulation system (negative association), and liver X receptor/retinoid X receptor activation (positive association). The relationship with inflammation was validated with multiple inflammatory markers measured with independent assays. Conclusions: Reduced circulating apo M is independently associated with adverse outcomes across the spectrum of human heart failure. Further research is needed to assess whether the apo M/S1P axis is a suitable therapeutic target in heart failure.
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| 39. |
- Elmegreen, Debra Meloy, et al.
(författare)
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HIERARCHICAL STAR FORMATION IN NEARBY LEGUS GALAXIES
- 2014
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Ingår i: Astrophysical Journal Letters. - 2041-8205. ; 787:1, s. L15-
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Tidskriftsartikel (refereegranskat)abstract
- Hierarchical structure in ultraviolet images of 12 late-type LEGUS galaxies is studied by determining the numbers and fluxes of nested regions as a function of size from similar to 1 to similar to 200 pc, and the number as a function of flux. Two starburst dwarfs, NGC 1705 and NGC 5253, have steeper number-size and flux-size distributions than the others, indicating high fractions of the projected areas filled with star formation. Nine subregions in seven galaxies have similarly steep number-size slopes, even when the whole galaxies have shallower slopes. The results suggest that hierarchically structured star-forming regions several hundred parsecs or larger represent common unit structures. Small galaxies dominated by only a few of these units tend to be starbursts. The self-similarity of young stellar structures down to parsec scales suggests that star clusters form in the densest parts of a turbulent medium that also forms loose stellar groupings on larger scales. The presence of super star clusters in two of our starburst dwarfs would follow from the observed structure if cloud and stellar subregions more readily coalesce when self-gravity in the unit cell contributes more to the total gravitational potential.
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| 40. |
- Gorski, Mathias, et al.
(författare)
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1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
- 2017
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10(-8) previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until whole-genome sequencing becomes feasible in large samples.
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| 41. |
- Gouliermis, Dimitrios A., et al.
(författare)
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Hierarchical star formation across the grand-design spiral NGC 1566
- 2017
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 468:1, s. 509-530
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Tidskriftsartikel (refereegranskat)abstract
- We investigate how star formation is spatially organized in the grand-design spiral NGC 1566 from deep Hubble Space Telescope photometry with the Legacy ExtraGalactic UV Survey. Our contour-based clustering analysis reveals 890 distinct stellar conglomerations at various levels of significance. These star- forming complexes are organized in a hierarchical fashion with the larger congregations consisting of smaller structures, which themselves fragment into even smaller and more compact stellar groupings. Their size distribution, covering a wide range in length-scales, shows a power law as expected from scale-free processes. We explain this shape with a simple 'fragmentation and enrichment' model. The hierarchical morphology of the complexes is confirmed by their mass-size relation that can be represented by a power law with a fractional exponent, analogous to that determined for fractal molecular clouds. The surface stellar density distribution of the complexes shows a lognormal shape similar to that for supersonic non-gravitating turbulent gas. Between 50 and 65 per cent of the recently formed stars, as well as about 90 per cent of the young star clusters, are found inside the stellar complexes, located along the spiral arms. We find an age difference between young stars inside the complexes and those in their direct vicinity in the arms of at least 10 Myr. This time-scale may relate to the minimum time for stellar evaporation, although we cannot exclude the in situ formation of stars. As expected, star formation preferentially occurs in spiral arms. Our findings reveal turbulent-driven hierarchical star formation along the arms of a grand-design galaxy.
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| 42. |
- Grasha, K., et al.
(författare)
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Connecting young star clusters to CO molecular gas in NGC 7793 with ALMA-LEGUS
- 2018
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 481:1, s. 1016-1027
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Tidskriftsartikel (refereegranskat)abstract
- We present an investigation of the relationship between giant molecular cloud (GMC) properties and the associated stellar clusters in the nearby flocculent galaxy NGC 7793. We combine the star cluster catalogue from the HST LEGUS (Legacy ExtraGalactic UV Survey) programme with the 15 pc resolution ALMA CO(2-1) observations. We find a strong spatial correlation between young star clusters and GMCs such that all clusters still associated with a GMC are younger than 11 Myr and display a median age of 2 Myr. The age distribution increases gradually as the cluster-GMC distance increases, with star clusters that are spatially unassociated with molecular gas exhibiting a median age of 7 Myr. Thus, star clusters are able to emerge from their natal clouds long before the time-scale required for clouds to disperse. To investigate if the hierarchy observed in the stellar components is inherited from the GMCs, we quantify the amount of clustering in the spatial distributions of the components and find that the star clusters have a fractal dimension slope of -0.35 +/- 0.03, significantly more clustered than the molecular cloud hierarchy with slope of -0.18 +/- 0.04 over the range 40-800 pc. We find, however, that the spatial clustering becomes comparable in strength for GMCs and star clusters with slopes of -0.44 +/- 0.03 and -0.45 +/- 0.06, respectively, when we compare massive (> 10(5) M-circle dot) GMCs to massive and young star clusters. This shows that massive star clusters trace the same hierarchy as their parent GMCs, under the assumption that the star formation efficiency is a few per cent.
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| 43. |
- Grasha, K., et al.
(författare)
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Hierarchical Star Formation in Turbulent Media : Evidence from Young Star Clusters
- 2017
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 842:1
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Tidskriftsartikel (refereegranskat)abstract
- We present an analysis of the positions and ages of young star clusters in eight local galaxies to investigate the connection between the age difference and separation of cluster pairs. We find that star clusters do not form uniformly but instead are distributed so that the age difference increases with the cluster pair separation to the 0.25-0.6 power, and that the maximum size over which star formation is physically correlated ranges from similar to 200. pc to similar to 1 kpc. The observed trends between age difference and separation suggest that cluster formation is hierarchical both in space and time: clusters that are close to each other are more similar in age than clusters born further apart. The temporal correlations between stellar aggregates have slopes that are consistent with predictions of turbulence acting as the primary driver of star formation. The velocity associated with the maximum size is proportional to the galaxy's shear, suggesting that the galactic environment influences the maximum size of the star-forming structures.
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| 44. |
- Grasha, K., et al.
(författare)
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THE SPATIAL DISTRIBUTION OF THE YOUNG STELLAR CLUSTERS IN THE STAR-FORMING GALAXY NGC 628
- 2015
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 815:2
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of the spatial distribution of the stellar cluster populations in the star-forming galaxy NGC 628. Using Hubble Space Telescope broadband WFC3/UVIS UV and optical images from the Treasury Program LEGUS (Legacy ExtraGalactic UV Survey), we have identified 1392 potential young (less than or similar to 100 Myr) stellar clusters within the galaxy using a combination of visual inspection and automatic selection. We investigate the clustering of these young stellar clusters and quantify the strength and change of clustering strength with scale using the two-point correlation function. We also investigate how image boundary conditions and dust lanes affect the observed clustering. The distribution of the clusters is well fit by a broken power law with negative exponent a. We recover a weighted mean index of alpha similar to -0.8 for all spatial scales below the break at 3.13 (158 pc at a distance of 9.9 Mpc) and an index of alpha similar to - 0.18 above 158 pc for the accumulation of all cluster types. The strength of the clustering increases with decreasing age and clusters older than 40 Myr lose their clustered structure very rapidly and tend to be randomly distributed in this galaxy, whereas the mass of the star cluster has little effect on the clustering strength. This is consistent with results from other studies that the morphological hierarchy in stellar clustering resembles the same hierarchy as the turbulent interstellar medium.
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| 45. |
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| 46. |
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| 47. |
- Heyer, Mark, et al.
(författare)
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The Dense Gas Mass Fraction and the Relationship to Star Formation in M51
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 930:2
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Tidskriftsartikel (refereegranskat)abstract
- Observations of 12CO J = 1 – 0 and HCN J = 1 – 0 emission from NGC 5194 (M51) made with the 50 m Large Millimeter Telescope and the SEQUOIA focal plane array are presented. Using the HCN-to-CO ratio, we examine the dense gas mass fraction over a range of environmental conditions within the galaxy. Within the disk, the dense gas mass fraction varies along the spiral arms but the average value over all spiral arms is comparable to the mean value of interarm regions. We suggest that the near-constant dense gas mass fraction throughout the disk arises from a population of density-stratified, self-gravitating molecular clouds and the required density threshold to detect each spectral line. The measured dense gas fraction significantly increases in the central bulge in response to the effective pressure, Pe, from the weight of the stellar and gas components. This pressure modifies the dynamical state of the molecular cloud population and, possibly, the HCN-emitting regions in the central bulge from self-gravitating to diffuse configurations in which Pe is greater than the gravitational energy density of individual clouds. Diffuse molecular clouds comprise a significant fraction of the molecular gas mass in the central bulge, which may account for the measured sublinear relationships between the surface densities of the star formation rate and molecular and dense gas.
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| 48. |
- Hsiao, Tiger Yu-Yang, et al.
(författare)
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JWST Reveals a Possible z similar to 11 Galaxy Merger in Triply Lensed MACS0647-JD
- 2023
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8205 .- 2041-8213. ; 949:2
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Tidskriftsartikel (refereegranskat)abstract
- MACS0647-JD is a triply lensed z similar to 11 galaxy originally discovered with the Hubble Space Telescope. The three lensed images are magnified by factors of similar to 8, 5, and 2 to AB mag 25.1, 25.6, and 26.6 at 3.5 mu m. The brightest is over a magnitude brighter than other galaxies recently discovered at similar redshifts z > 10 with JWST. Here, we report new JWST imaging that clearly resolves MACS0647-JD as having two components that are either merging galaxies or stellar complexes within a single galaxy. The brighter larger component "A" is intrinsically very blue (ss similar to-2.6 +/- 0.1), likely due to very recent star formation and no dust, and is spatially extended with an effective radius similar to 70 +/- 24 pc. The smaller component "B" (r similar to 20-+ 58 pc) appears redder (ss similar to-2 +/- 0.2), likely because it is older (100-200 Myr) with mild dust extinction (AV similar to 0.1 mag). With an estimated stellar mass ratio of roughly 2:1 and physical projected separation similar to 400 pc, we may be witnessing a galaxy merger 430 million years after the Big Bang. We identify galaxies with similar colors in a high-redshift simulation, finding their star formation histories to be dissimilar, which is also suggested by the spectral energy distribution fitting, suggesting they formed further apart. We also identify a candidate companion galaxy "C" similar to 3 kpc away, likely destined to merge with A and B. Upcoming JWST Near Infrared Spectrograph observations planned for 2023 January will deliver spectroscopic redshifts and more physical properties for these tiny magnified distant galaxies observed in the early universe.
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| 49. |
- Jung, Dooseok Escher, et al.
(författare)
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Universal Upper End of the Stellar Initial Mass Function in the Young and Compact LEGUS Clusters
- 2023
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 954:2
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the variation in the upper end of the stellar initial mass function (uIMF) in 375 young and compact star clusters in five nearby galaxies within ∼5 Mpc. All the young stellar clusters (YSCs) in the sample have ages ≲ 4 Myr and masses above 500 M⊙, according to standard stellar models. The YSC catalogs were produced from Hubble Space Telescope images obtained as part of the Legacy ExtraGalactic UV Survey (LEGUS) Hubble treasury program. They are used here to test whether the uIMF is universal or changes as a function of the cluster's stellar mass. We perform this test by measuring the Hα luminosity of the star clusters as a proxy for their ionizing photon rate, and charting its trend as a function of cluster mass. Large cluster numbers allow us to mitigate the stochastic sampling of the uIMF. The advantage of our approach relative to previous similar attempts is the use of cluster catalogs that have been selected independently of the presence of Hα emission, thus removing a potential sample bias. We find that the uIMF, as traced by the Hα emission, shows no dependence on cluster mass, suggesting that the maximum stellar mass that can be produced in star clusters is universal, in agreement with previous findings.
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| 50. |
- Linden, S. T., et al.
(författare)
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Star Cluster Formation and Evolution in M101 : An Investigation with the Legacy Extragalactic UV Survey
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 935:2
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Tidskriftsartikel (refereegranskat)abstract
- We present Hubble Space Telescope WFC3/UVIS (F275W, F336W) and ACS/WFC optical (F435W, F555W, and F814W) observations of the nearby grand-design spiral galaxy M101 as part of the Legacy Extragalactic UV Survey (LEGUS). Compact sources detected in at least four bands were classified by both human experts and the convolutional neural network StarcNet. Human experts classified the 2351 brightest sources, retrieving N-c = 965 star clusters. StarcNet, trained on LEGUS data not including M101, classified all 4725 sources detected in four bands, retrieving N-c = 2270 star clusters. The combined catalog represents the most complete census to date of compact star clusters in M101. We find that for the 2351 sources with both a visual- and machine-learning classification StarcNet is able to reproduce the human classifications at high levels of accuracy (similar to 80%-90%), which is equivalent to the level of agreement between human classifiers in LEGUS. The derived cluster age distribution implies a disruption rate of dN/d tau proportional to tau(-0.45 +/- 0.14) over 10(7) < tau < 10(8.5) yr for cluster masses >= 10(3.55) M-circle dot for the central region of M101 and dN/d tau proportional to tau(-0.02 +/- 0.15) for cluster masses >= 10(3.38) M-circle dot in the northwest region of the galaxy. The trends we recover are weaker than those of other nearby spirals (e.g., M51) and starbursts, consistent with the M101 environment having a lower-density interstellar medium, and providing evidence in favor of environmentally dependent cluster disruption in the central, southeast, and northwest regions of M101.
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