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- Roselli, Carolina, et al.
(författare)
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Multi-ethnic genome-wide association study for atrial fibrillation
- 2018
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233
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Tidskriftsartikel (refereegranskat)abstract
- Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
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| 7. |
- Young, William J., et al.
(författare)
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Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
- 2022
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease. The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.
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- Smith, ER, et al.
(författare)
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Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis
- 2023
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Ingår i: BMJ global health. - : BMJ. - 2059-7908. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.MethodsWe screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.ResultsWe screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection—as compared with uninfected pregnant women—were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.ConclusionsThis analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more data become available, we will update these findings per the published protocol.
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- Palikhe, A, et al.
(författare)
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Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease.
- 2008
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Ingår i: Tissue Antigens. - : Wiley. - 0001-2815 .- 1399-0039. ; 71:6, s. 530-7
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Tidskriftsartikel (refereegranskat)abstract
- Periodontitis and coronary artery disease (CAD) are inflammatory diseases and associated with each other. The major histocompatibility complex (MHC) region carries genes involved in immune response and inflammation. We investigated whether the MHC genes correlate with the presence of periodontitis or with the occurrence of periodontal pathogens in patients with CAD. Blood and saliva samples from CAD patients (n = 106) were collected at the time of hospitalization. Nine MHC genetic markers [human leukocyte antigen (HLA)-A, HLA-B, HLA-DRB1, lymphotoxin alpha (LTA) +253(a/g), +496(C/T), +633(c/g), +724(C/A), C4A and C4B)] were typed. Based on panoramic tomography, patients were categorized into nonperiodontitis and periodontitis groups. Two major periodontal pathogens, Aggregatibacter (Actinobacillus) actinomycetemcomitans and Porphyromonas gingivalis, were cultivated and polymerase chain reaction-amplified from salivary samples. Serum immunoglobulin (Ig)A and IgG antibody levels to these pathogens were measured. In the univariate analysis, LTA+496C allele (OR = 5.29; 95% CI = 2.07-13.51, P = 0.00027), and the occurrence of P. gingivalis in saliva (OR = 4.74; 95% CI = 1.64-13.70; P = 0.002) were more frequent in periodontitis when compared with nonperiodontitis. Similarly, serum IgA antibody level against the pathogen was increased in periodontitis (P = 0.048). In the multiple logistic regression analysis, when a wide range of covariates was included, the LTA+496C allele (OR = 10.87; 95% CI = 3.23-36.60; P = 0.00012) and the elevated serum IgA antibody level against P. gingivalis (OR = 1.56; 95% CI = 1.05-2.30; P = 0.026) remained as significant risk factors for periodontitis. In conclusion, the major finding of this study is that the LTA+496C allele is associated with periodontitis in patients with CAD.
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- Stephansson, O., et al.
(författare)
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SARS-CoV-2 and pregnancy outcomes under universal and non-universal testing in Sweden: register-based nationwide cohort study
- 2022
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Ingår i: Bjog-an International Journal of Obstetrics and Gynaecology. - : Wiley. - 1470-0328 .- 1471-0528. ; 129:2, s. 282-290
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Tidskriftsartikel (refereegranskat)abstract
- Objective To assess associations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and pregnancy outcomes considering testing policy and test-positivity-to-delivery interval. Design Nationwide cohort study. Setting Sweden. Population From the Pregnancy-Register we identified 88 593 singleton births, 11 March 2020-31 January 2021, linked to data on SARS-CoV-2-positivity from the Public Health Agency, and information on neonatal care admission from the Neonatal Quality Register. Adjusted odds ratios (aORs) were estimated stratified by testing-policy and test-positivity-to-delivery interval. Main outcome measures Five-minute Apgar score, neonatal care admission, stillbirth and preterm birth. Results During pregnancy, SARS-CoV-2 test-positivity was 5.4% (794/14 665) under universal testing and 1.9% (1402/73 928) under non-universal testing. There were generally lower risks associated with SARS-CoV-2 under universal than non-universal testing. In women testing positive >10 days from delivery, generally no significant differences in risk were observed under either testing policy. Neonatal care admission was more common (15.3% versus 8.0%; aOR 2.24, 95% CI 1.62-3.11) in women testing positive <= 10 days before delivery under universal testing. There was no significant association with 5-minute Apgar score below 7 (1.0% versus 1.7%; aOR 0.64, 95% CI 0.24-1.72) or stillbirth (0.3% versus 0.4%; aOR 0.72, 95% CI 0.10-5.20). Compared with term births (2.1%), test-positivity was higher in medically indicated preterm birth (5.7%; aOR 2.70, 95% CI 1.60-4.58) but not significantly increased in spontaneous preterm birth (2.3%; aOR 1.12, 95% CI 0.62-2.02). Conclusions Testing policy and timing of test-positivity impact associations between SARS-CoV-2-positivity and pregnancy outcomes. Under non-universal testing, women with complications near delivery are more likely to be tested than women without complications, thereby inflating any association with adverse pregnancy outcomes compared with findings under universal testing. Tweetable abstract Testing policy and time from SARS-CoV-2 infection to delivery influence the association with pregnancy outcomes.
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| 21. |
- Ahlberg, Martina, et al.
(författare)
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Freezing and thawing magnetic droplet solitons
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Magnetic droplets are a type of non-topological magnetic soliton, which are stabilised and sustained by spin-transfer torques for instance. Without this, they would collapse. Here Ahlberg et al show that by decreasing the applied magnetic field, droplets can be frozen, forming a static nanobubble Magnetic droplets are non-topological magnetodynamical solitons displaying a wide range of complex dynamic phenomena with potential for microwave signal generation. Bubbles, on the other hand, are internally static cylindrical magnetic domains, stabilized by external fields and magnetostatic interactions. In its original theory, the droplet was described as an imminently collapsing bubble stabilized by spin transfer torque and, in its zero-frequency limit, as equivalent to a bubble. Without nanoscale lateral confinement, pinning, or an external applied field, such a nanobubble is unstable, and should collapse. Here, we show that we can freeze dynamic droplets into static nanobubbles by decreasing the magnetic field. While the bubble has virtually the same resistance as the droplet, all signs of low-frequency microwave noise disappear. The transition is fully reversible and the bubble can be thawed back into a droplet if the magnetic field is increased under current. Whereas the droplet collapses without a sustaining current, the bubble is highly stable and remains intact for days without external drive. Electrical measurements are complemented by direct observation using scanning transmission x-ray microscopy, which corroborates the analysis and confirms that the bubble is stabilized by pinning.
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| 25. |
- Bergström, Stig M., et al.
(författare)
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Darriwili (Keskordoviitsiumi) δ13Corg kemostratigraafia koos graptoliitide biostratigraafiaga klassikalisel röstånga alal skåne maakonna loodeosas lõunarootsis
- 2020
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Ingår i: Estonian Journal of Earth Sciences. - : Estonian Academy Publishers. - 1736-4728. ; 69:3, s. 121-133
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Tidskriftsartikel (refereegranskat)abstract
- The largely covered Middle Ordovician succession in the classic geological Röstånga area in northwestern Scania has not been studied for some 80 years. A new drill core through a succession ranging from the lower–middle Darriwilian to the lower Sandbian has provided a unique opportunity to investigate the graptolite biostratigraphy and the δ13Corg chemostratigraphy, and clarify their stratigraphic relations, through this ~90 m thick interval, which is developed within a black shale facies. The lithology, biostratigraphy and chemostratigraphy are closely similar to those of the coeval strata in the Fågelsång area, southcentral Scania, including the presence of the Fågelsång Phosphorite, which was previously unrecorded in the Röstånga area. The new data are particularly important in providing evidence of the relations between graptolite biostratigraphy and δ13Corg chemostratigraphy. The Fågelsång3 and Röstånga2 drill core successions are currently the only Darriwilian sequences in the world where these relations have been well established.
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| 26. |
- Bergström, Stig M., et al.
(författare)
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Darriwilian (Middle Ordovician) chemostratigraphy linked to graptolite, conodont and trilobite biostratigraphy in the Fågelsång-3 drill core, Scania, Sweden
- 2018
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Ingår i: GFF. - : Informa UK Limited. - 2000-0863 .- 1103-5897. ; 140:3, s. 229-240
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Tidskriftsartikel (refereegranskat)abstract
- A recent core drilling in the geologically classical Fågelsång area resulted in a 58.70-m-long drill core through the lowermost Sandbian Sularp Shale, the Darriwilian Almelund Shale and Komstad Limestone, and part of the late Tremadocian to earliest Darriwilian Tøyen Shale. The shales contain zone index graptolites that are used for an update of the standard Darriwilian graptolite zone succession in Baltoscandia in which six zones are now recognized. The Komstad Limestone interval and lowermost part of the Almelund Shale have beensubdivided into four conodont zones. The δ13Corg chemostratigraphy, which has been established through the entire drill core based on 120 closely spaced samples, shows a somewhat subdued development of the middle Darriwilian Isotope Carbon Excursion (MDICE), which is dated in terms of graptolite biostratigraphy. The Fågelsång isotope curve is correlated with a closely similar δ13Ccarb curve from a coeval, apparently stratigraphically essentially continuous, succession at Kårgärde in south-central Sweden, which previously has been subdivided into 13 conodont zones and subzones. For the first time, these conodont zonal units can be calibrated with Fågelsång graptolite zones using δ13Corg chemostratigraphy. The several new results of this study are expected to be useful for assessing biostratigraphic relations between units in shale and carbonate facies in Baltoscandia and elsewhere in the world.
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| 27. |
- Braglia, L., et al.
(författare)
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Understanding Solid-Gas Reaction Mechanisms by Operando Soft X-Ray Absorption Spectroscopy at Ambient Pressure
- 2020
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Ingår i: Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 124:26, s. 14202-14212
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Tidskriftsartikel (refereegranskat)abstract
- Ambient-pressure operando soft X-ray absorption spectroscopy (soft-XAS) was applied to study the reactivity of hydroxylated SnO(2 )nanoparticles toward reducing gases. H-2 was first used as a test case, showing that the gas phase and surface states can be simultaneously probed: Soft-XAS at the O K-edge gains sensitivity toward the gas phase, while at the Sn M-4,M-5-edges, tin surface states are explicitly probed. Results obtained by flowing hydrocarbons (CH4 and CH3CHCH2) unequivocally show that these gases react with surface hydroxyl groups to produce water without producing carbon oxides and release electrons that localize on Sn to eventually form SnO. The partially reduced SnO2-x layer at the surface of SnO2 is readily reoxidized to SnO2 by treating the sample with O-2 at mild temperatures (>200 degrees C), revealing the nature of "electron sponge" of tin oxide. The experiments, combined with DFT calculations, allowed devising of a mechanism for dissociative hydrocarbon adsorption on SnO2, involving direct reduction of Sn sites at the surface via cleavage of C-H bonds and the formation of methoxy- and/or methyl-tin species at the surface.
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| 29. |
- Crawley, C, et al.
(författare)
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Outcomes for reduced-intensity allogeneic transplantation for multiple myeloma: an analysis of prognostic factors from the Chronic Leukaemia Working Party of the EBMT
- 2005
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 105:11, s. 4532-4539
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Tidskriftsartikel (refereegranskat)abstract
- We report the outcome of 229 patients who received an allograft for myeloma with reduced-intensity conditioning (RIC) regimens from 33 centers within the European Group for Blood and Marrow Transplantation (EBMT). The median age was 52 years and 64% were male. Conditioning regimens were heterogeneous, but most were fludarabine based and T cell depleted with antithymocyte globulin or alemtuzumab. Transplantation-related mortality (TRIM) at 1 year was 22%. The 3-year overall survival (OS) and progression-free survival (PFS) were 41% and 21 %, respectively. Adverse OS was associated with chemoresistant disease (relative risk [RR], 2.9), more than 1 prior transplantation (RR, 2.0), and male patients with female donors (FIR, 1.45). Adverse PFS was associated with chemoresistance (RR, 2.4) and alemtuzumab (RR, 1.8). TRM was increased with female-to-male donation (RR, 2.5) and transplantation more than 1 year from diagnosis (RR, 2.3). Grades II to IV acute graft-versus-host disease (aGvHD) occurred in 31%. Chronic GvHD was associated with better OS and PFS and were 84% and 46% for limited, 58% and 30% for extensive, and 29% and 12% in its absence suggesting that a graft-versus-myeloma effect is important. While RIC is feasible, heavily pretreated patients and patients with progressive disease do not benefit.
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| 30. |
- Eyrich, C., et al.
(författare)
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Effects of substitution on the exchange stiffness and magnetization of Co films
- 2014
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 90:23, s. 235408-
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Tidskriftsartikel (refereegranskat)abstract
- An antiferromagnetically coupled FM/NM/FM (FM = ferromagnet, NM = normal metal) trilayer structure responds to an external magnetic field by the formation of a magnetic-moment spring within the FM layers. We show that the exchange stiffness (A ex) of an FM layer can be determined by fitting the field-dependent magnetization, M(H), of the FM/NM/FM trilayer to a micromagnetic model. Using this method, we have measured the exchange stiffness of thin-film Co alloyed with Cr, Fe, Ni, Pd, Pt, and Ru. The results show that the rate at which a substituent element reduces the exchange stiffness is not directly related to its effect on the magnetization of the alloy. The observed trends have been understood by material-specific modeling based on density functional theory within the local density approximation. The stiffness measurements are in agreement with Brillouin light scattering carried out on thicker Co films.
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| 34. |
- Jana, Somnath, et al.
(författare)
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Analysis of the linear relationship between asymmetry and magnetic moment at the M edge of 3d transition metals
- 2020
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Ingår i: Physical Review Research. - : American Physical Society. - 2643-1564. ; 2:1
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Tidskriftsartikel (refereegranskat)abstract
- The magneto-optical response of Fe and Ni during ultrafast demagnetization is studied experimentally and theoretically. We have performed pump-probe experiments in the transverse magneto-optical Kerr effect (T-MOKE) geometry using photon energies that cover the M absorption edges of Fe and Ni between 40 and 72 eV. The magnetic asymmetry was obtained by forming the difference of reflected intensities obtained for two opposite orientations of the sample magnetization. Density functional theory (DFT) was used to calculate the magneto-optical response of different magnetic configurations, representing different types of excitations: long wavelength magnons, short wavelength magnons, and Stoner excitations. In the case of Fe, we find that the calculated asymmetry is strongly dependent on the specific type of magnetic excitation. Our modeling also reveals that during remagnetization Fe is, to a reasonable approximation, described by magnons, even though small nonlinear contributions could indicate some degree of Stoner excitations as well. In contrast, we find that the calculated asymmetry in Ni is rather insensitive to the type of magnetic excitations. However, there is a weak nonlinearity in the relation between asymmetry and the off-diagonal component of the dielectric tensor, which does not originate from the modifications of the electronic structure. Our experimental and theoretical results thus emphasize the need to consider a coupling between asymmetry and magnetization that may be more complex than a simple linear relationship. This insight is crucial for the microscopic interpretation of ultrafast magnetization experiments.
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| 43. |
- Mohseni, M., et al.
(författare)
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Chiral excitations of magnetic droplet solitons driven by their own inertia
- 2020
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Ingår i: Physical Review B. - : AMER PHYSICAL SOC. - 2469-9950 .- 2469-9969. ; 101:2
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Tidskriftsartikel (refereegranskat)abstract
- The inertial effects of magnetic solitons play a crucial role in their dynamics and stability. Yet governing their inertial effects is a challenge for their use in real devices. Here, we show how to control the inertial effects of magnetic droplet solitons. Magnetic droplets are more strongly nonlinear and localized autosolitons than can form in current-driven nanocontacts. Droplets can be considered as dynamical particles with an effective mass. We show that the dynamical droplet bears a second excitation under its own inertia. These excitations comprise a chiral profile, and appear when the droplet resists the force induced by the Oersted field of the current injected into the nanocontact. We reveal the role of the spin torque on the excitation of these chiral modes and we show how to control these modes using the current and the field.
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| 45. |
- Njoroge, Kezia M., et al.
(författare)
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Voices unheard : Youth and sexuality in the wake of HIV prevention in Kenya
- 2010
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Ingår i: Sexual & Reproductive HealthCare. - : Elsevier BV. - 1877-5756 .- 1877-5764. ; 1:4, s. 143-148
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveThe aim of the study was to explore the concerns of young people on sexuality in its social contexts in the era of HIV/AIDS in three districts in Kenya.Study designYoung people in Kajiado, Kirinyaga and Meru Districts were requested to write questions on sexuality and related problems that later formed the basis for discussion in community dialogue meetings with adults. The social ecological conceptual model (SEM) was used to illuminate the contextual factors and actors influencing sexual behaviours among young people.ResultsThe study suggests that young people and adults are concerned about honest and open communication on sexuality. Predominant concerns for the young people were love, sexual urge, desires or sexual wellness and condom use. Their questions suggest that young people are sexually active, yet have little knowledge on sexual matters. The results describe a prohibitive silence from adults, an issue reflected in the questions from the school youth.ConclusionThis study suggests the need to move from seeing sexuality as a problem and focus on sexual wellness and the positive aspects of sexuality. The adult participants suggested that bringing men and women together for reflection and discussion in a participatory mode, transformative learning and change could be achieved. It is vital that the youth and adults have open communication as a foundation for youth to mature into adults. This can be achieved, if interventions including research address multiple contextual factors such as cultural norms, gender differences, as well as communication barriers.
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| 46. |
- Norman, M., et al.
(författare)
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Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes
- 2021
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Ingår i: Jama-Journal of the American Medical Association. - : American Medical Association (AMA). - 0098-7484 .- 1538-3598. ; 325:20, s. 2076-2086
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE The outcomes of newborn infants of women testing positive for SARS-CoV-2 in pregnancy is unclear. OBJECTIVE To evaluate neonatal outcomes in relation to maternal SARS-CoV-2 test positivity in pregnancy. DESIGN, SETTING, AND PARTICIPANTS Nationwide, prospective cohort study based on linkage of the Swedish Pregnancy Register, the Neonatal Quality Register, and the Register for Communicable Diseases. Ninety-two percent of all live births in Sweden between March 11, 2020, and January 31, 2021, were investigated for neonatal outcomes by March 8, 2021. Infants with malformations were excluded. Infants of women who tested positive for SARS-CoV-2 were matched, directly and using propensity scores, on maternal characteristics with up to 4 comparator infants. EXPOSURES Maternal test positivity for SARS-CoV-2 in pregnancy. MAIN OUTCOMES AND MEASURES In-hospital mortality; neonatal resuscitation; admission for neonatal care; respiratory, circulatory, neurologic, infectious, gastrointestinal, metabolic, and hematologic disorders and their treatments; length of hospital stay; breastfeeding; and infant test positivity for SARS-CoV-2. RESULTS Of 88 159 infants (49.0% girls), 2323 (1.6%) were delivered by mothers who tested positive for SARS-CoV-2. The mean gestational age of infants of SARS-CoV-2-positive mothers was 39.2 (SD, 2.2) weeks vs 39.6 (SD, 1.8) weeks for comparator infants, and the proportions of preterm infants (gestational age <37 weeks) were 205/2323 (8.8%) among infants of SARS-CoV-2-positive mothers and 4719/85 836 (5.5%) among comparator infants. After matching on maternal characteristics, maternal SARS-CoV-2 test positivity was significantly associated with admission for neonatal care (11.7% vs 8.4%; odds ratio [OR], 1.47; 95% CI, 1.26-1.70) and with neonatal morbidities such as respiratory distress syndrome (1.2% vs 0.5%; OR, 2.40; 95% CI, 1.50-3.84), any neonatal respiratory disorder (2.8% vs 2.0%; OR, 1.42; 95% CI, 1.07-1.90), and hyperbilirubinemia (3.6% vs 2.5%; OR, 1.47; 95% CI, 1.13-1.90). Mortality (0.30% vs 0.12%; OR, 2.55; 95% CI, 0.99-6.57), breastfeeding rates at discharge (94.4% vs 95.1%; OR, 0.84; 95% CI, 0.67-1.05), and length of stay in neonatal care (median, 6 days in both groups; difference, 0 days; 95% CI, -2 to 7 days) did not differ significantly between the groups. Twenty-one infants (0.90%) of SARS-CoV-2-positive mothers tested positive for SARS-CoV-2 in the neonatal period; 12 did not have neonatal morbidity, 9 had diagnoses with unclear relation to SARS-CoV-2, and none had congenital pneumonia. CONCLUSIONS AND RELEVANCE In a nationwide cohort of infants in Sweden, maternal SARS-CoV-2 infection in pregnancy was significantly associated with small increases in some neonatal morbidities. Given the small numbers of events for many of the outcomes and the large number of statistical comparisons, the findings should be interpreted as exploratory.
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| 48. |
- Peng, Shanchi, et al.
(författare)
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The Cambrian Period
- 2020
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Ingår i: Geologic Time Scale. - 9780128243633 - 9780128243619 ; 2, s. 565-565
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Bokkapitel (refereegranskat)abstract
- Appearance of metazoans with mineralized skeletons, “explosion” in biotic diversity and disparity, infaunalization of the substrate, occurrence of metazoan Konservat Fossil-lagerstätten, establishment of most invertebrate phyla, strong faunal provincialism, dominance of trilobites, generally warm climate but with possibleglacial-interglacial cycles in the later part, opening of the Iapetus Ocean, progressive equatorial drift and separation of Laurentia, Baltica, Siberia, and Avalonia from Gondwana characterize the Cambrian Period.
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| 49. |
- Peng, Shanchi, et al.
(författare)
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Trilobites
- 2020
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Ingår i: Geologic Timescale 2020. - 9780128243626 - 9780128243619 ; 1, s. 36-36
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Bokkapitel (refereegranskat)abstract
- Trilobites are marine arthropods that appeared in Cambrian Epoch 2 and became extinct at the end of the Permian. In some Paleozoic deposits, they number among the most abundant macrofossils. Trilobites are important for early Paleozoic biostratigraphy, especially Cambrian.
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