| 1. |
- Ahlsén, Bertil, et al.
(author)
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Ombyggnad Torslanda
- 1990
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Reports (other academic/artistic)abstract
- Consumer report for the company in question (the Volvo Automobile Company and the Volvo Torslanda plant) which is financed by the company and partly also by a research foundation. It is a matter of a work that in this particular case were carried out during nine years in a number of experimental workshops located outside the Chalmers University of Technology. These workshops were financed by the Volvo Automobile and Truck companies. This achievement, as the final contribution to the Swedish automotive industry after having already treated this research field/problem area for more than two decades before this particular period if time (involving several junior and senior research competencies, as well as industrial and governmental foundings).
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| 2. |
- Andersson, H.O., et al.
(author)
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Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors
- 2003
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In: European Journal of Biochemistry. - : Wiley. - 0014-2956 .- 1432-1033. ; 270:8, s. 1746-1758
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Journal article (peer-reviewed)abstract
- HIV-1 protease is an important target for treatment of AIDS, and efficient drugs have been developed. However, the resistance and negative side effects of the current drugs has necessitated the development of new compounds with different binding patterns. In this study, nine C-terminally duplicated HIV-1 protease inhibitors were cocrystallised with the enzyme, the crystal structures analysed at 1.8-2.3 Å resolution, and the inhibitory activity of the compounds characterized in order to evaluate the effects of the individual modifications. These compounds comprise two central hydroxy groups that mimic the geminal hydroxy groups of a cleavage-reaction intermediate. One of the hydroxy groups is located between the d-oxygen atoms of the two catalytic aspartic acid residues, and the other in the gauche position relative to the first. The asymmetric binding of the two central inhibitory hydroxyls induced a small deviation from exact C2 symmetry in the whole enzyme-inhibitor complex. The study shows that the protease molecule could accommodate its structure to different sizes of the P2/P2' groups. The structural alterations were, however, relatively conservative and limited. The binding capacity of the S3/S3' sites was exploited by elongation of the compounds with groups in the P3/P3' positions or by extension of the P1/P1' groups. Furthermore, water molecules were shown to be important binding links between the protease and the inhibitors. This study produced a number of inhibitors with Ki values in the 100 picomolar range.
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| 6. |
- Allwood, Jens, et al.
(author)
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On identifying conflict related stances in political debates
- 2012
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In: Proceedings - 2012 ASE/IEEE International Conference on Privacy, Security, Risk and Trust and 2012 ASE/IEEE International Conference on Social Computing, SocialCom/PASSAT 2012. - 9780769548487 ; , s. 918-925
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Conference paper (peer-reviewed)abstract
- The purpose of this paper is to discuss some problems in identifying stances and the features that express these stances in televised political debates where there is conflict escalation. The study is based on an analysis of video-recorded political debates in different European languages (Italian (1), German (2) and US-American English (1)) and consists of a qualitative analysis of the videos in order to understand the similarities and differences in the use of social signals for stances in conflict situations in a similar setting (televised political debate) in three western cultures. ©2012 IEEE.
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| 7. |
- Allwood, Jens, 1947, et al.
(author)
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The Analysis of Embodied Communicative Feedback in Multimodal Corpora - a prerequisite for behavior simulation.
- 2008
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In: Language Resources and Evaluation. - : Springer Netherlands. - 1574-020X .- 1574-0218 .- 1572-8412. ; 41:3-4, s. 255-272
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Journal article (peer-reviewed)abstract
- Communicative feedback refers to unobtrusive (usually short) vocal or bodily expressions whereby a recipient of information can inform a contributor of information about whether he/she is able and willing to communicate, perceive the information, and understand the information. This paper provides a theory for embodied communicative feedback, describing the different dimensions and features involved. It also provides a corpus analysis part, describing a first data coding and analysis method geared to find the features postulated by the theory. The corpus analysis part describes different methods and statistical procedures and discusses their applicability and the possible insights gained with these methods.
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| 9. |
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| 10. |
- Bang, P, et al.
(author)
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Free insulin-like growth factor I: are we hunting a ghost?
- 2001
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In: Hormone research. - : S. Karger AG. - 0301-0163. ; 5555 Suppl 2, s. 84-93
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Journal article (peer-reviewed)abstract
- During the last decade, there has been an increasing number of publications reporting concentrations of free dissociable insulin-like growth factor I (IGF-I) in serum or plasma. The goal for attempting to measure free IGF-I in a serum sample in vitro has been to obtain information about the bioactivity of IGF-I in target tissues, and thus relate a measurable parameter to biological responses such as longitudinal growth or glucose disappearance rate. In this review, the serum free IGF-I approach is placed into a physiological perspective. In addition, methodological aspects are discussed and suggestions for the validation of free IGF-I assays are presented.
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| 11. |
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| 12. |
- Chindamo, M., et al.
(author)
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Some suggestions for the study of stance in communication
- 2012
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In: Proceedings - 2012 ASE/IEEE International Conference on Privacy, Security, Risk and Trust and 2012 ASE/IEEE International Conference on Social Computing, SocialCom/PASSAT 2012. - 9780769548487 ; , s. 617-622
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Conference paper (peer-reviewed)abstract
- Interlocutors, express not only information in the form of spoken words but also their feelings and commitments with regard to what is being said. In face-to-face communication participants interact in such a way that they react to one another’s multimodal positioning in the conversation. Often this means that they take a ’stance’. The goal of this paper is to explore the notion of stance through a review and discussion of some of the relevant literature and then relate this to research on social signal processing (SSP). The main focus of the review is on the notion of stance in linguistics, as the point of departure for exploring other fields. Consideration of the relation between gestural communication and expression of emotions will give a more complete view of how a stance is taken and upheld. ©2012 IEEE.
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| 14. |
- Karlsson, HKR, et al.
(author)
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Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients
- 2006
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 55:5, s. 1283-1288
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Journal article (peer-reviewed)abstract
- Aberrant insulin signaling and glucose metabolism in skeletal muscle from type 2 diabetic patients may arise from genetic defects and an altered metabolic milieu. We determined insulin action on signal transduction and glucose transport in isolated vastus lateralis skeletal muscle from normal glucose-tolerant first-degree relatives of type 2 diabetic patients (n = 8, 41 ± 3 years, BMI 25.1 ± 0.8 kg/m2) and healthy control subjects (n = 9, 40 ± 2 years, BMI 23.4 ± 0.7 kg/m2) with no family history of diabetes. Basal and submaximal insulin-stimulated (0.6 and 1.2 nmol/l) glucose transport was comparable between groups, whereas the maximal response (120 nmol/l) was 38% lower (P < 0.05) in the relatives. Insulin increased phosphorylation of Akt and Akt substrate of 160 kDa (AS160) in a dose-dependent manner, with comparable responses between groups. AS160 phosphorylation and glucose transport were positively correlated in control subjects (R2 = 0.97, P = 0.01) but not relatives (R2 = 0.46, P = 0.32). mRNA of key transcriptional factors and coregulators of mitochondrial biogenesis were also determined. Skeletal muscle mRNA expression of peroxisome proliferator–activated receptor (PPAR) γ coactivator (PGC)-1α, PGC-1β, PPARδ, nuclear respiratory factor-1, and uncoupling protein-3 was comparable between first-degree relatives and control subjects. In conclusion, the uncoupling of insulin action on Akt/AS160 signaling and glucose transport implicates defective GLUT4 trafficking as an early event in the pathogenesis of type 2 diabetes.
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| 18. |
- Rosenhall, U, et al.
(author)
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Autism and hearing loss
- 1999
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In: Journal of autism and developmental disorders. - : Springer Science and Business Media LLC. - 0162-3257. ; 29:5, s. 349-357
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Journal article (peer-reviewed)
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