| 1. |
- Fitzmauric, C., et al.
(författare)
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Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived with Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 : A Systematic Analysis for the Global Burden of Disease Study
- 2019
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Ingår i: JAMA Oncology. - : American Medical Association. - 2374-2437 .- 2374-2445. ; 5:12, s. 1749-1768
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Tidskriftsartikel (refereegranskat)abstract
- Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.Objective: To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning.Evidence Review: We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence.Findings: In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572000 deaths and 15.2 million DALYs), and stomach cancer (542000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601000 deaths and 17.4 million DALYs), TBL cancer (596000 deaths and 12.6 million DALYs), and colorectal cancer (414000 deaths and 8.3 million DALYs).Conclusions and Relevance: The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care.
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| 2. |
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| 4. |
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| 5. |
- Stanaway, Jeffrey D., et al.
(författare)
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Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
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Tidskriftsartikel (refereegranskat)abstract
- Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
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| 6. |
- Lozano, Rafael, et al.
(författare)
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Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - : Elsevier. - 1474-547X .- 0140-6736. ; 392:10159, s. 2091-2138
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Tidskriftsartikel (refereegranskat)abstract
- Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health-related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990–2017, projected indicators to 2030, and analysed global attainment. Methods: We measured progress on 41 health-related SDG indicators from 1990 to 2017, an increase of four indicators since GBD 2016 (new indicators were health worker density, sexual violence by non-intimate partners, population census status, and prevalence of physical and sexual violence [reported separately]). We also improved the measurement of several previously reported indicators. We constructed national-level estimates and, for a subset of health-related SDGs, examined indicator-level differences by sex and Socio-demographic Index (SDI) quintile. We also did subnational assessments of performance for selected countries. To construct the health-related SDG index, we transformed the value for each indicator on a scale of 0–100, with 0 as the 2·5th percentile and 100 as the 97·5th percentile of 1000 draws calculated from 1990 to 2030, and took the geometric mean of the scaled indicators by target. To generate projections through 2030, we used a forecasting framework that drew estimates from the broader GBD study and used weighted averages of indicator-specific and country-specific annualised rates of change from 1990 to 2017 to inform future estimates. We assessed attainment of indicators with defined targets in two ways: first, using mean values projected for 2030, and then using the probability of attainment in 2030 calculated from 1000 draws. We also did a global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends. Using 2015 global averages of indicators with defined SDG targets, we calculated the global annualised rates of change required from 2015 to 2030 to meet these targets, and then identified in what percentiles the required global annualised rates of change fell in the distribution of country-level rates of change from 1990 to 2015. We took the mean of these global percentile values across indicators and applied the past rate of change at this mean global percentile to all health-related SDG indicators, irrespective of target definition, to estimate the equivalent 2030 global average value and percentage change from 2015 to 2030 for each indicator. Findings: The global median health-related SDG index in 2017 was 59·4 (IQR 35·4–67·3), ranging from a low of 11·6 (95% uncertainty interval 9·6–14·0) to a high of 84·9 (83·1–86·7). SDG index values in countries assessed at the subnational level varied substantially, particularly in China and India, although scores in Japan and the UK were more homogeneous. Indicators also varied by SDI quintile and sex, with males having worse outcomes than females for non-communicable disease (NCD) mortality, alcohol use, and smoking, among others. Most countries were projected to have a higher health-related SDG index in 2030 than in 2017, while country-level probabilities of attainment by 2030 varied widely by indicator. Under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria indicators had the most countries with at least 95% probability of target attainment. Other indicators, including NCD mortality and suicide mortality, had no countries projected to meet corresponding SDG targets on the basis of projected mean values for 2030 but showed some probability of attainment by 2030. For some indicators, including child malnutrition, several infectious diseases, and most violence measures, the annualised rates of change required to meet SDG targets far exceeded the pace of progress achieved by any country in the recent past. We found that applying the mean global annualised rate of change to indicators without defined targets would equate to about 19% and 22% reductions in global smoking and alcohol consumption, respectively; a 47% decline in adolescent birth rates; and a more than 85% increase in health worker density per 1000 population by 2030. Interpretation: The GBD study offers a unique, robust platform for monitoring the health-related SDGs across demographic and geographic dimensions. Our findings underscore the importance of increased collection and analysis of disaggregated data and highlight where more deliberate design or targeting of interventions could accelerate progress in attaining the SDGs. Current projections show that many health-related SDG indicators, NCDs, NCD-related risks, and violence-related indicators will require a concerted shift away from what might have driven past gains—curative interventions in the case of NCDs—towards multisectoral, prevention-oriented policy action and investments to achieve SDG aims. Notably, several targets, if they are to be met by 2030, demand a pace of progress that no country has achieved in the recent past. The future is fundamentally uncertain, and no model can fully predict what breakthroughs or events might alter the course of the SDGs. What is clear is that our actions—or inaction—today will ultimately dictate how close the world, collectively, can get to leaving no one behind by 2030.
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| 7. |
- Murray, Christopher J. L., et al.
(författare)
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Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1995-2051
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Tidskriftsartikel (refereegranskat)abstract
- Background: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use standardised estimates of mortality. We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods. Methods: We estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods. We based the estimates on the demographic balancing equation, with inputs of fertility, mortality, population, and migration data. Fertility data came from 7817 location-years of vital registration data, 429 surveys reporting complete birth histories, and 977 surveys and censuses reporting summary birth histories. We estimated age-specific fertility rates (ASFRs; the annual number of livebirths to women of a specified age group per 1000 women in that age group) by use of spatiotemporal Gaussian process regression and used the ASFRs to estimate total fertility rates (TFRs; the average number of children a woman would bear if she survived through the end of the reproductive age span [age 10–54 years] and experienced at each age a particular set of ASFRs observed in the year of interest). Because of sparse data, fertility at ages 10–14 years and 50–54 years was estimated from data on fertility in women aged 15–19 years and 45–49 years, through use of linear regression. Age-specific mortality data came from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 estimates. Data on population came from 1257 censuses and 761 population registry location-years and were adjusted for underenumeration and age misreporting with standard demographic methods. Migration was estimated with the GBD Bayesian demographic balancing model, after incorporating information about refugee migration into the model prior. Final population estimates used the cohort-component method of population projection, with inputs of fertility, mortality, and migration data. Population uncertainty was estimated by use of out-of-sample predictive validity testing. With these data, we estimated the trends in population by age and sex and in fertility by age between 1950 and 2017 in 195 countries and territories. Findings: From 1950 to 2017, TFRs decreased by 49·4% (95% uncertainty interval [UI] 46·4–52·0). The TFR decreased from 4·7 livebirths (4·5–4·9) to 2·4 livebirths (2·2–2·5), and the ASFR of mothers aged 10–19 years decreased from 37 livebirths (34–40) to 22 livebirths (19–24) per 1000 women. Despite reductions in the TFR, the global population has been increasing by an average of 83·8 million people per year since 1985. The global population increased by 197·2% (193·3–200·8) since 1950, from 2·6 billion (2·5–2·6) to 7·6 billion (7·4–7·9) people in 2017; much of this increase was in the proportion of the global population in south Asia and sub-Saharan Africa. The global annual rate of population growth increased between 1950 and 1964, when it peaked at 2·0%; this rate then remained nearly constant until 1970 and then decreased to 1·1% in 2017. Population growth rates in the southeast Asia, east Asia, and Oceania GBD super-region decreased from 2·5% in 1963 to 0·7% in 2017, whereas in sub-Saharan Africa, population growth rates were almost at the highest reported levels ever in 2017, when they were at 2·7%. The global average age increased from 26·6 years in 1950 to 32·1 years in 2017, and the proportion of the population that is of working age (age 15–64 years) increased from 59·9% to 65·3%. At the national level, the TFR decreased in all countries and territories between 1950 and 2017; in 2017, TFRs ranged from a low of 1·0 livebirths (95% UI 0·9–1·2) in Cyprus to a high of 7·1 livebirths (6·8–7·4) in Niger. The TFR under age 25 years (TFU25; number of livebirths expected by age 25 years for a hypothetical woman who survived the age group and was exposed to current ASFRs) in 2017 ranged from 0·08 livebirths (0·07–0·09) in South Korea to 2·4 livebirths (2·2–2·6) in Niger, and the TFR over age 30 years (TFO30; number of livebirths expected for a hypothetical woman ageing from 30 to 54 years who survived the age group and was exposed to current ASFRs) ranged from a low of 0·3 livebirths (0·3–0·4) in Puerto Rico to a high of 3·1 livebirths (3·0–3·2) in Niger. TFO30 was higher than TFU25 in 145 countries and territories in 2017. 33 countries had a negative population growth rate from 2010 to 2017, most of which were located in central, eastern, and western Europe, whereas population growth rates of more than 2·0% were seen in 33 of 46 countries in sub-Saharan Africa. In 2017, less than 65% of the national population was of working age in 12 of 34 high-income countries, and less than 50% of the national population was of working age in Mali, Chad, and Niger. Interpretation: Population trends create demographic dividends and headwinds (ie, economic benefits and detriments) that affect national economies and determine national planning needs. Although TFRs are decreasing, the global population continues to grow as mortality declines, with diverse patterns at the national level and across age groups. To our knowledge, this is the first study to provide transparent and replicable estimates of population and fertility, which can be used to inform decision making and to monitor progress. Funding: Bill & Melinda Gates Foundation.
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| 8. |
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| 9. |
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| 10. |
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| 11. |
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| 12. |
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| 13. |
- Akbari, H., et al.
(författare)
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In Situ Electron Density From Active Sounding : The Influence of the Spacecraft Wake
- 2019
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Ingår i: Geophysical Research Letters. - : AMER GEOPHYSICAL UNION. - 0094-8276 .- 1944-8007. ; 46:17-18, s. 10250-10256
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Tidskriftsartikel (refereegranskat)abstract
- Results obtained in the Martian ionosphere by the Langmuir Probe and Waves instrument aboard the Mars Atmosphere and Volatile EvolutioN Mission spacecraft are presented. The results include ionospheric electron densities determined from the frequency of Langmuir waves. Since the amplitude of thermal Langmuir waves is often below the instrument's detection level, Langmuir Probe and Waves excites these waves by injecting into the plasma a 3.3-V white noise signal. Electric field spectral measurements obtained shortly after the excitation show a resonance line at frequencies slightly below the local plasma frequency. The observed resonance line is interpreted to originate from plasma waves excited in the wake behind the spacecraft. These results reveal an important phenomenon in electron density estimation from stimulated Langmuir waves. The observed phenomenon, not previously reported by earlier missions, may be a common process in active sounding that can affect in situ electron density measurements.
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| 14. |
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| 15. |
- Akbari, H., et al.
(författare)
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Optimization of baker's yeast drying in industrial continuous fluidized-bed dryer
- 2012
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Ingår i: Food and Bioproducts Processing. - : Elsevier Ltd. - 0960-3085 .- 1744-3571. ; 90:1, s. 52-57
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Tidskriftsartikel (refereegranskat)abstract
- Instant active dry baker's yeast is a well-known product widely used for leavening of bread, produced by fermentation, and usually dried by hot air to 94–96% dry matter content. Multi-stage fluidized bed drying process is a commercial effective method for yeast drying. In this work, optimum operating parameters of an industrial continuous fluidized bed dryer for the production of instant active dry yeast were investigated. The dryer contained four zones separated with moving weirs. The operating conditions such as temperature, loading rate of compressed yeast granules, and hot air humidity had direct effects on both yeast activity and viability. The most important factors that affected the quality of the product were loading rate and the operational temperature in each zone on the bed. Optimization was performed for three loading rates of the feed to the dryer, using response surface methodology for the experimental design. The most significant factor was shown to be the loading rate with mean fermentation activity values of 620, 652, and 646 cm3 CO2/h for 300, 350, and 400 kg/h loading rates, respectively. The data analysis resulted in an optimal operating point at a loading rate of 350 kg/h and temperatures of zones 1, 2, 3, and 4 controlled at 33, 31, 31, and 29 °C, respectively. The best activity value was predicted as 668 ± 18 cm3 CO2/h, and confirmation experiments resulted in 660 ± 10 cm3 CO2/h. At the same operating point, the average viability of the cells was predicted as 74.8 ± 3.7% and confirmed as 76.4 ± 0.6%. Compared with the normal operating conditions at the plant, the optimization resulted in more than 12% and 27% improvement in the yeast activity and viability, respectively.
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| 16. |
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| 17. |
- Akbari, Mehdi, et al.
(författare)
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The Persian Exercise Addiction Inventory—Adult and Youth Versions : Psychometric Properties Based on Rasch Analysis Among Iranians
- 2023
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Ingår i: International Journal of Mental Health and Addiction. - : Springer. - 1557-1874 .- 1557-1882. ; 21, s. 3376-3392
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Tidskriftsartikel (refereegranskat)abstract
- Exercise addiction is a morbid-compulsive behavioral pattern characterized by a loss of control over exercise and which results in major detrimental consequences in the affected individual’s life. Although the condition is not formally recognized in official psychiatric texts, exercise addiction can lead to clinical impairment of everyday activities just like other more traditional addictions. This has led to the development of many instruments to assess exercise addiction. One of the most widely used instruments is the Exercise Addiction Inventory (EAI) which has been translated into a number of languages and has separate versions of the scale for adults and adolescents (i.e., the EAI-Y for youth). However, there are currently no Persian versions. Therefore, the present study translated the EAI into Persian and assessed its psychometric properties using Rasch analysis among both Iranian adults (n = 745, age range = 19–30 years, 60.53% female) and Iranian adolescents (n = 562, age range = 13–18 years, 62.45% female). An online survey was used to collect data from September to November 2021. Confirmatory factor analyses and the Rasch analyses confirmed the unidimensional structure of the EAIs and good reliability using the Omega coefficient (.71 to.72). Also, separation reliability on item, scale, and person-level was established, along with supported measurement invariance, demonstrating that EAI can discriminate individuals on a high or low level of exercise addiction independent of their age and gender. Overall, the Persian EAI demonstrated sound psychometrics in screening for exercise addiction among Iranian adults and adolescents.
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| 18. |
- Akbari, Parsa, et al.
(författare)
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Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 373:6550
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Tidskriftsartikel (refereegranskat)abstract
- Large-scale human exome sequencing can identify rare protein-coding variants with a large impact on complex traits such as body adiposity. We sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico and estimated associations of rare coding variants with body mass index (BMI). We identified 16 genes with an exome-wide significant association with BMI, including those encoding five brain-expressed G protein-coupled receptors (CALCR, MC4R, GIPR, GPR151, and GPR75). Protein-truncating variants in GPR75 were observed in ∼4/10,000 sequenced individuals and were associated with 1.8 kilograms per square meter lower BMI and 54% lower odds of obesity in the heterozygous state. Knock out of Gpr75 in mice resulted in resistance to weight gain and improved glycemic control in a high-fat diet model. Inhibition of GPR75 may provide a therapeutic strategy for obesity.
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| 19. |
- Akbari, Saeed, et al.
(författare)
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Multimaterial 3D Printed Soft Actuators Powered by Shape Memory Alloy Wires
- 2019
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Ingår i: Sensors and Actuators A-Physical. - : Elsevier BV. - 0924-4247 .- 1873-3069. ; 290, s. 177-189
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Tidskriftsartikel (refereegranskat)abstract
- Shape memory alloys (SMAs) have been widely used to fabricate soft actuators by embedding SMA wires into various soft matrices manufactured by conventional moulding methods or novel three-dimensional (3D) printing techniques. However, soft matrices of SMA based actuators are typically fabricated from only one or two different materials. Here, we exploit the great manufacturing flexibility of multimaterial 3D printing to fabricate various bending, twisting and extensional actuators by precisely controlling the spatial arrangements of different printing materials with different stiffnesses. In order to achieve a broad range of deformations, ten different printing materials were characterized and used in the actuators design. In addition, we developed a finite element model to simulate complex deformations of the printed actuators and facilitate the design process. The model incorporates a user defined material subroutine that describes the nonlinear temperature dependant behavior of SMAs. The results show the efficiency and flexibility of multimaterial 3D printing in tailoring the deformed shape of the SMA based soft actuators, which cannot be accomplished using conventional manufacturing methods such as moulding.
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| 20. |
- Akbari, Saeed, et al.
(författare)
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Shape memory alloy based 3D printed composite actuators with variable stiffness and large reversible deformation
- 2021
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Ingår i: Sensors and Actuators A-Physical. - : Elsevier B.V.. - 0924-4247 .- 1873-3069. ; 321
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Tidskriftsartikel (refereegranskat)abstract
- Soft composite actuators can be fabricated by embedding shape memory alloy (SMA) wires into soft polymer matrices. Shape retention and recovery of these actuators are typically achieved by incorporating shape memory polymer segments into the actuator structure. However, this requires complex manufacturing processes. This work uses multimaterial 3D printing to fabricate composite actuators with variable stiffness capable of shape retention and recovery. The hinges of the bending actuators presented here are printed from a soft elastomeric layer as well as a rigid shape memory polymer (SMP) layer. The SMA wires are embedded eccentrically over the entire length of the printed structure to provide the actuation bending force, while the resistive wires are embedded into the SMP layer of the hinges to change the temperature and the bending stiffness of the actuator hinges via Joule heating. The temperature of the embedded SMA wire and the printed SMP segments is changed sequentially to accomplish a large bending deformation, retention of the deformed shape, and recovery of the original shape, without applying any external mechanical force. The SMP layer thickness was varied to investigate its effect on shape retention and recovery. A nonlinear finite element model was used to predict the deformation of the actuators.
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| 21. |
- Akbari, Saeed, et al.
(författare)
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Shape-reversible 4D printing aided by shape memory alloys
- 2022
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Ingår i: Smart Materials in Additive Manufacturing, volume 2: 4D Printing Mechanics, Modeling, and Advanced Engineering Applications. - : Elsevier. - 9780323954303 - 9780323954310 ; , s. 387-406
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Four-dimensional (4D) printed structures fabricated from shape memory polymers (SMPs) are typically one-way actuators, that is, for each actuation cycle, they must be programmed to deform from the original (as-printed) shape to a secondary (programmed) shape. This is done by applying a combination of thermal and mechanical loads. Then, they restore the initial shape during the actuation process by applying a thermal load. Here, we generalize this concept to fabricate two-way actuators by embedding shape memory alloy (SMA) wires into the printed SMP structures. To explain this in greater detail, we describe the printing process of a two-way bending actuator whose bilayer hinges consist of stiff SMPs as well as elastomers with low modulus. Joule heating was employed to modulate the hinges bending stiffness. To this end, electrical current was applied to the resistive wires inserted into the hinges SMP layer to control their temperature. On the other hand, thermomechanical programming of the SMA wires, which were integrated into the actuator, provided the bending actuation force. The fabricated actuator was able to bend, maintain the deformed shape, and recover the as-fabricated shape in a fully automated manner. Further potentials of this design methodology were assessed using a nonlinear finite element model. The model incorporated user-defined subroutines to incorporate complex material behaviors of SMAs and SMPs.
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| 22. |
- Akbari-Saatlu, Mehdi, et al.
(författare)
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H2S gas sensing based on SnO2thin films deposited by ultrasonic spray pyrolysis on Al2O3substrate
- 2021
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Ingår i: 2021 IEEE Sensors Applications Symposium (SAS). - 9781728194318
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Konferensbidrag (refereegranskat)abstract
- H2S gas is harmful for human health and environment, therefore novel gas sensors for real time and fast detection with high precision have been sought. Metal oxides are already known as promising candidate for this purpose. This article presents the performance of a gas sensor consists of a microheater and active layer formed on single alumina substrate for operating at high temperature applications. Ultrasonic spray pyrolysis deposition method was used to make both thick layer of SnO2 for microheater and thin and porous crystalline layer of SnO2 as sensing layer. The prepared sensor showed suitable dynamic response towards 10 to 50 ppm of H2S gas both in humid and dry conditions at 450 °C. In these experiments, the cross sensitivity of the sensor was also checked for other interfering gases e.g. CH4 and NO2.
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| 23. |
- Akbari-Saatlu, Mehdi, et al.
(författare)
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Nanometer-Thick ZnO/SnO2Heterostructures Grown on Alumina for H2S Sensing
- 2022
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Ingår i: ACS Applied Nano Materials. - : American Chemical Society (ACS). - 2574-0970. ; 5:5, s. 6954-6963
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Tidskriftsartikel (refereegranskat)abstract
- Designing heterostructure materials at the nanoscale is a well-known method to enhance gas sensing performance. In this study, a mixed solution of zinc chloride and tin (II) chloride dihydrate, dissolved in ethanol solvent, was used as the initial precursor for depositing the sensing layer on alumina substrates using the ultrasonic spray pyrolysis (USP) method. Several ZnO/SnO2 heterostructures were grown by applying different ratios in the initial precursors. These heterostructures were used as active materials for the sensing of H2S gas molecules. The results revealed that an increase in the zinc chloride in the USP precursor alters the H2S sensitivity of the sensor. The optimal working temperature was found to be 450 °C. The sensor, containing 5:1 (ZnCl2: SnCl2·2H2O) ratio in the USP precursor, demonstrates a higher response than the pure SnO2 (∼95 times) sample and other heterostructures. Later, the selectivity of the ZnO/SnO2 heterostructures toward 5 ppm NO2, 200 ppm methanol, and 100 ppm of CH4, acetone, and ethanol was also examined. The gas sensing mechanism of the ZnO/SnO2 was analyzed and the remarkably enhanced gas-sensing performance was mainly attributed to the heterostructure formation between ZnO and SnO2. The synthesized materials were also analyzed by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray, transmission electron microscopy, and X-ray photoelectron spectra to investigate the material distribution, grain size, and material quality of ZnO/SnO2 heterostructures.
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| 24. |
- Akbari-Saatlu, Mehdi, et al.
(författare)
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Silicon Nanowires for Gas Sensing : A Review
- 2020
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Ingår i: Nanomaterials. - : MDPI AG. - 2079-4991. ; 10:11
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Forskningsöversikt (refereegranskat)abstract
- The unique electronic properties of semiconductor nanowires, in particular silicon nanowires (SiNWs), are attractive for the label-free, real-time, and sensitive detection of various gases. Therefore, over the past two decades, extensive efforts have been made to study the gas sensing function of NWs. This review article presents the recent developments related to the applications of SiNWs for gas sensing. The content begins with the two basic synthesis approaches (top-down and bottom-up) whereby the advantages and disadvantages of each approach have been discussed. Afterwards, the basic sensing mechanism of SiNWs for both resistor and field effect transistor designs have been briefly described whereby the sensitivity and selectivity to gases after different functionalization methods have been further presented. In the final words, the challenges and future opportunities of SiNWs for gas sensing have been discussed.
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| 25. |
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| 26. |
- Ekenback, C, et al.
(författare)
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Changes in Index of Microcirculatory Resistance during PCI in the Left Anterior Descending Coronary Artery in Relation to Total Length of Implanted Stents
- 2019
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Ingår i: Journal of interventional cardiology. - : Hindawi Limited. - 1540-8183 .- 0896-4327. ; 2019, s. 1397895-
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Tidskriftsartikel (refereegranskat)abstract
- Aim. To investigate the relationship between stent length and changes in microvascular resistance during PCI in stable coronary artery disease (CAD). Methods and Results. We measured fractional flow reserve (FFR), index of microcirculatory resistance (IMR), and coronary flow reserve (CFR) before and after stenting in 42 consecutive subjects with stable coronary artery undergoing PCI with stent in the LAD. Patients that had very long stent length (38–78 mm) had lower FFR before stenting than patients that had long (23–37 mm) and moderate (12–22 mm) stent length (0.59 (±0.16), 0.70 (±0.12), and 0.75 (±0.07); p=0.002). FFR improved after stenting and more so in subjects with very long stent length compared to long and moderate stent length (0.27 (s.d ± 16), 0.15 (s.d ± 0.12), and 0.12 (s.d ± 0.07); p for interaction = 0.013). Corrected IMR (IMRcorr) increased after stenting in subjects who had very long stent length, whereas IMRcorr was lower after stenting in subjects who had long or moderate stent length (4.6 (s.d. ± 10.7), −1.4 (s.d. ± 9,9), and −4.2 (s.d. ± 7.8); p for interaction = 0.009). Conclusions. Changes in IMR during PCI in the LAD in stable CAD seem to be related to total length of stents implanted, possibly influencing post-PCI FFR. Larger studies are needed to confirm the relationship.
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| 27. |
- Hirsch, M. A., et al.
(författare)
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Sub-5km baseline tomography for fine-scale auroral measurements
- 2014
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Ingår i: 2014 United States National Committee of URSI National Radio Science Meeting, USNC-URSI NRSM 2014. - : IEEE. - 9781479931200 ; , s. 6928074-
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Konferensbidrag (refereegranskat)abstract
- Auroral morphologies are a direct result of the specific energy levels driving the optical emissions as well as the spreading of wave energy. The emphasis of the present work is on identifying apparent auroral feature motion in both the B∥ and B⊥ dimensions in order to uncover the physical model responsible for wave spreading under the given electron beam excitation. The auroral B∥ dimension is known to experience a change in shape and peak optical emission for given electron beam energies, and forward models have been previously established for these phenomena. The transverse proper motion of auroral features is related to spreading of energy in the B⊥ direction. Several theories have been advanced to explain the auroral transverse proper motion, but previous observational efforts have been limited to temporal scales on the order of a second. Our new observational facility is capable of simultaneously resolving features to the decameter scale spatially and millisecond scale temporally{a capability not available until now thanks to recent advances in Electron-Multiplying Charge Coupled Device (EMCCD) technology that are triggerable with sub-millisecond accuracy from GPS-disciplined trigger sources. We can thereby combine multiple simultaneous 2D optical observations with arbitrarily physical separation to take tightly time-synchronized observations of extremely faint optical phenomena for tomographic inversion.
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| 28. |
- Ivanov, I. I., et al.
(författare)
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Expanding catalytic sensor capabilities to combustible gas mixtures monitoring
- 2022
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Ingår i: Measurement. - : Elsevier. - 0263-2241 .- 1873-412X. ; 194
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Tidskriftsartikel (refereegranskat)abstract
- Preventing the explosion of mixtures of combustible gases and vapors is an important task in industry. This research presents an approach for rapid assessment of the explosiveness of combustible gas mixtures of unknown composition. The technique is based on registering the amount of heat released during the combustion of a portion of gases inside the catalytic sensor. The phenomenological theory of the approach for rapid assessment of the explosiveness was also presented. To carry out the measurements, a two-stage heating pulse and an approach to the calibration of the catalytic sensor were developed. The experiments were carried out for various mixtures of methane, propane, butane and hexane within the pre-explosive range (up to 50% Low Explosive Limit). In order to calculate the Lower Explosive Limit (LEL) of a mixture of flammable gases, Le Chatelier's rule was used. Industrial catalytic sensors with additional diaphragm that limits the gas leakage into the sensor were used for measurements. The advanced data processing which is based on integrating the area under the measured dependence of sensor response on time was used to calculate the heat released. The parameters affecting the measurement results were analyzed. The measurement values were in good agreement with the prescribed values. The measurement errors did not exceed 10%. Since in this approach there is no need to identify gases, or their quantity and concentration, it can be used in industry for quick determination of potentially explosive mixtures in the air.
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| 29. |
- Li, You, et al.
(författare)
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Si and SiGe Nanowire for Micro-Thermoelectric Generator : A Review of the Current State of the Art
- 2021
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Ingår i: Frontiers in Materials. - : Frontiers Media SA. - 2296-8016. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- In our environment, the large availability of wasted heat has motivated the search for methods to harvest heat. As a reliable way to supply energy, SiGe has been used for thermoelectric generators (TEGs) in space missions for decades. Recently, micro-thermoelectric generators (μTEG) have been shown to be a promising way to supply energy for the Internet of Things (IoT) by using daily waste heat. Combining the predominant CMOS compatibility with high electric conductivity and low thermal conductivity performance, Si nanowire and SiGe nanowire have been a candidate for μTEG. This review gives a comprehensive introduction of the Si, SiGe nanowires, and their possibility for μTEG. The basic thermoelectric principles, materials, structures, fabrication, measurements, and applications are discussed in depth.
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| 30. |
- Mehrvar, N, et al.
(författare)
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ATP-Binding Cassette transporters' gene expression in pediatric patients with acute leukemia; a comprehensive analysis of published reports through PubMed search engine
- 2019
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Ingår i: Cellular and molecular biology (Noisy-le-Grand, France). - : CMB Association. - 1165-158X .- 0145-5680. ; 65:2, s. 7-13
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Tidskriftsartikel (refereegranskat)abstract
- Multidrug resistance based on ABC transporters' gene expression is one of the most important health challenges through chemotherapy of patients. This resistance can cause relapse or treatment failure. The goal of this conducted study was to evaluate the results of published reports which considered ABC transporters' gene expression in pediatric patients with acute leukemia. PubMed as a free search engine was chosen. The following Mesh terms were used as: "ATP-binding cassette transporters” OR "ABC-transporters*” AND "gene expression*” AND "leukemia” OR "ALL” OR "AML” OR "acute leukemia*”. Age was set as an additional filter with the age range of birth to 18 years old. Initial screening was performed according to inclusion and exclusion criteria and the quality of the selected papers was assessed. Papers categorized into three sections as: pediatric patients with ALL (6 papers from 1998-2015); pediatric patients with AML (3 papers from 1992-2011) and pediatric patients with ALL and AML (7 papers from 1992-2014). Totally 1118 patients enrolled in the searched studies (ALL and AML: 488; ALL: 405; AML: 225). The common method for evaluating gene expression of ABC transporters was RT-PCR. More than 50% of the papers showed the influence of ABC transporters' gene expression on prognosis and treatment failures of patients. Despite controversial results, the gathered information in the current report serves as a comprehensive referential resource, which can be beneficial for future planning around this title, especially in developing countries.
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| 31. |
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| 32. |
- Mir-Akbari, H, et al.
(författare)
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Limitations of 64-detector-row computed tomography coronary angiography: calcium and motion but not short experience
- 2009
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 50:2, s. 174-180
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Tidskriftsartikel (refereegranskat)abstract
- Background: Recently, 64-detector-row computed tomography coronary angiography (CTA) has been introduced for the noninvasive diagnosis of coronary artery disease. Purpose: To evaluate the diagnostic capacity and limitations of a newly established CTA service. Material and Methods: In 101 outpatients with suspected coronary artery disease, 64-detector-row CTA (VCT Lightspeed 64; GE Healthcare, Milwaukee, Wisc., USA) was performed before invasive coronary angiography (ICA). The presence of >50% diameter coronary stenosis on CTA was rated by two radiologists recently trained in CTA, and separately by an experienced colleague. Diagnostic performance of CTA was calculated on segment, vessel, and patient levels, using ICA as a reference. Segments with a proximal reference diameter <2 mm or with stents were not analyzed. Results: In 51 of 101 patients and 121 of 1280 segments, ICA detected coronary stenosis. In 274 of 1280 (21%) segments, CTA had non-diagnostic image quality, the main reasons being severe calcifications (49%), motion artifacts associated with high or irregular heart rate (45%), and low contrast opacification (14%). Significantly more women (43%) had non-diagnostic scans compared to men (20%). A heart rate above 60 beats per minute was associated with significantly more non-diagnostic patients (38% vs. 18%). In the 1006 diagnostic segments, CTA had a sensitivity of 78%, specificity of 95%, positive predictive value (PPV) of 54%, and negative predictive value (NPV) of 98% for detecting significant coronary stenosis. In 29 patients, CTA was non-diagnostic. In the remaining 72 patients, sensitivity was 100%, specificity 65%, PPV 79%, and NPV 100%. The use of a more experienced CTA reader did not improve diagnostic performance. Conclusion: CTA had a very high negative predictive value, but the number of non-diagnostic scans was high, especially in women. The main limitations were motion artifacts and vessel calcifications, while short experience in CTA did not influence the interpretation.
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| 33. |
- Mishra, U., et al.
(författare)
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Dynamical quantum correlations after sudden quenches
- 2018
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Ingår i: Physical Review A. - 2469-9926. ; 98:5
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Tidskriftsartikel (refereegranskat)abstract
- We employ the mean-field approach in the fermionic picture of the spin-1/2 XXZ chain to investigate the dynamics of bipartite quantum discord and concurrence under sudden quenching. In this case, when quenching is performed in the anisotropy from an initial value to the critical point, the quantum correlations show periodic cusps in time. Moreover, the first suppression (cusp) in quantum correlations can be explained in terms of the semiclassical picture of quasiparticle propagation. On the other hand, quenching to, as well as away from, the criticality point shows that the long time pairwise quantum discord gets enhanced from its initial state. Finally, we show that, in the gapped region, a quench in the transverse field displays survival of the next-nearest-neighbor quantum discord. Our results provide a further insight into the dynamical behavior of quantum correlations and their connections to quantum criticality.
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| 34. |
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| 35. |
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| 37. |
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| 38. |
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| 39. |
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| 40. |
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| 41. |
- Ripsweden, J, et al.
(författare)
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Is training essential for interpreting cardiac computed tomography?
- 2009
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 50:2, s. 194-200
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Tidskriftsartikel (refereegranskat)abstract
- Background: Cardiac computed tomography (CT) has gained increasing acceptance for diagnosing obstructive coronary artery disease (CAD). Several guidelines have been published on required education for proficiency in the interpretation of these examinations. Purpose: To describe the learning-curve effect of the interpretation of 100 consecutive cardiac CT examinations aimed at diagnosing CAD. The diagnostic accuracy of radiologists and radiographers was also compared. Material and Methods: Two radiologists and two radiographers, all with no prior experience in evaluation of cardiac CT, independently underwent a dedicated training program of 100 examinations randomized into 10 blocks (sessions), with 10 cases in each. They independently evaluated the coronary arteries regarding significant obstructive CAD. After every session, individual feedback on diagnostic accuracy and comparison with the corresponding invasive coronary angiography (currently regarded as the gold standard to detect coronary lesions) was given. The time required for interpretation was recorded. Results: The mean review time decreased ( P<0.0001) successively during the 10 sessions for all the observers together. The first session had a mean review time of 32 min, and the last session 16 min. No significant improvement in sensitivity, specificity, or negative predictive value (NPV) was observed. For positive predictive value (PPV), there was an improvement for the radiologists ( P<0.05), but not for the radiographers. The radiographers had a higher total specificity compared to the radiologists ( P<0.01). Conclusion: The review time for novices in cardiac CT was approximately halved during the first 100 cases, with maintained accuracy. There was a learning-curve effect in PPV for the radiologists. The diagnostic accuracy of dedicated radiographers indicates that they might be considered to be included as part of the evaluation team.
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| 42. |
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| 43. |
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| 45. |
- Salimi, L., et al.
(författare)
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Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor cells
- 2020
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Ingår i: Cell and Bioscience. - : Springer Science and Business Media LLC. - 2045-3701. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Background Eukaryotic cells demonstrate two tightly linked vesicular transport systems, comprising intracellular vesicle transport and extracellular vesicle transport system. Intracellular transport vesicles can translocate biomolecules between compartments inside the cell, for example, proteins from the rough endoplasmic reticulum to the Golgi apparatus. Whereas, the secreted vesicles so-called extracellular vesicles facilitate the transport of biomolecules, for example, nucleic acids, proteins and lipids between cells. Vesicles can be formed during the process of endocytosis or/and autophagy and not only act as mediators of intra- and inter-cellular communication but also represent pathological conditions of cells or tissues. Methods In this review, we searched articles in PubMed, published between 2000 and 2020, with following terms: autophagy, autophagocytosis, transport vesicles, lysosomes, endosomes, exocytosis, exosomes, alone or in different combinations. The biological functions that were selected based on relevancy to our topic include cellular homeostasis and tumorigenesis. Results The searched literature shows that there is a high degree of synergies between exosome biogenesis and autophagy, which encompass endocytosis and endosomes, lysosomes, exocytosis and exosomes, autophagocytosis, autophagosomes and amphisomes. These transport systems not only maintain cellular homeostasis but also operate synergically against fluctuations in the external and internal environment such as during tumorigenesis and metastasis. Additionally, exosomal and autophagic proteins may serve as cancer diagnosis approaches. Conclusion Exosomal and autophagy pathways play pivotal roles in homeostasis and metastasis of tumor cells. Understanding the crosstalk between endomembrane organelles and vesicular trafficking may expand our insight into cooperative functions of exosomal and autophagy pathways during disease progression and may help to develop effective therapies against lysosomal diseases including cancers and beyond.
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