| 1. |
- Al-Bishri, Awwad, et al.
(författare)
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Effect of betamethasone on the degree of macrophage recruitment and nerve growth factor receptor p75 immunoreaction during recovery of the sciatic nerve after injury : an experimental study in rats.
- 2008
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Ingår i: British Journal of Oral & Maxillofacial Surgery. - : Elsevier BV. - 0266-4356 .- 1532-1940. ; 46:6, s. 455-9
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: This study was designed to explain our previous findings of beneficial effects of betamethasone given perioperatively on decreasing the incidence of neurosensory disturbance after sagittal split osteotomy and improving functional recovery after crush injury to rat sciatic nerves. We analysed the pattern of macrophage recruitment and expression of nerve growth factor p75. MATERIAL AND METHODS: The sciatic nerve was crushed in each of 42 animals by tying the nerve against a glass rod for 30s. Half the rats were given betamethasone and half were not. The effect of betamethasone was evaluated immunohistochemically in a double blind manner after 2, 7 and 17 days using antibodies against macrophage marker (ED1) and p75. RESULTS: We found an initial and significant decrease in the number of macrophages recruited after two days in the group treated with betamethasone compared with controls (p=0.001). By 7 days there were significantly more macrophages in the steroid group than in the control group (p=0.001). There was however, a tendency for the number of p75R to be higher in the in the steroid group but the difference was not significant. At 17 days, there were significantly fewer macrophages in the steroid group (p=0.008) than in the control. CONCLUSION: We conclude that the beneficial effect of a moderate perioperative dose of betamethasone on recovery of a nerve is reflected in the recruitment of macrophages but to only a small extent in expression of p75.
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| 2. |
- Al-Harthy, Mohammad, et al.
(författare)
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Temporomandibular disorder pain in adult Saudi Arabians referred for specialised dental treatment
- 2010
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Ingår i: Swedish Dental Journal. - : Swedish Dental Association. - 0347-9994. ; 34:3, s. 149-158
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to determine the frequency of Temporomandibular Disorders (TMD) pain in Saudi Arabians,aged 20-40, who were referred to the Specialist Dental Centre in Makkah. The material included 325 patients (135 males,190 females) who answered a history questionnaire. Patients reportingTMD pain in the last month were offered a clinical examination. History questionnaires and clinical examinations were done according to the Arabic version of the Research Diagnostic Criteria for TMD (RDC/TMD). Fifty-eight patients (18%) reported TMD pain; 46 were clinically examined. Mean age of clinically examined TMD pain patients was 30 +/- 7 years with a male-female ratio of 1:6 (P < 0.001). All TMD pain patients had a diagnosis of myofascial pain, and 65% had diagnoses of arthralgia or osteoarthritis. Headaches or migraines in the last 6 months and headaches in the last month were reported in high frequencies in the TMD pain group, 93% and 71% respectively, with differences (P < 0.001) between the TMD pain and non-TMD pain groups. Graded Chronic Pain Scale assessments classified 45% of the TMD pain patients in grade 1, 53% in grade II, 2% in grade III, and 0% in grade IV. Severe depression scores were found in 38% of the TMD pain patients and severe somatisation scores in 60% with differences (P < 0.001) between the TMD pain and non-TMD pain groups. In conclusion, the study found a frequency of TMD pain in this Saudi Arabian cohort of 18%. The TMD pain group presented high scores of depression and somatisation but low disability grades on the Graded Chronic Pain Scale.
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| 3. |
- Al-Harthy, Mohammad, et al.
(författare)
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Temporomandibular Disorders per RDC/TMD in Adult Saudi Arabians Referred for Specialized Dental Treatment
- 2008
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Objective: The aim of this study was to determine frequency of Temporomandibular Disorders (TMD) pain in Saudi Arabians, ages 20 to 40, which were referred to a dental specialist clinic in Makkah. Materials and Methods: 325 referred patients (135 males, 190 females) answered history questionnaires. Patients reporting TMD pain in these questionnaires were clinically examined. History questionnaires and clinical examinations were done per Axis I and Axis II of the Arabic version of Research Diagnostic Criteria for TMD (RDC/TMD). Results: The male-female ratio of the study group was 1:1.4. Fifty-eight patients (18%) had TMD pain; 46 were clinically examined. Mean age of examined TMD pain patients was 30 years (±7) with a male-female ratio of 1:6. All TMD pain patients had a diagnosis of myofascial pain and 65% had diagnoses of arthralgia or osteoarthritis. Graded chronic pain severity was reported to be grade I in 45%, grade II in 53%, grade III in 2% and grade IV in none of the patients. Psychological status assessment showed that 38% of the TMD pain patients had severe depression scores and 60% severe somatization scores. Conclusion: The present study showed a high frequency of TMD pain in this Saudi Arabian cohort, and 18% of the patients met criteria for subdiagnoses of TMD. Depression and somatization per Axis II had significantly higher scores in the TMD pain group compared to the non-pain group.
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| 4. |
- Al-Harthy, Mohammad, et al.
(författare)
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TMD in Adult Saudi Arabians According to RDC/TMD
- 2008
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Konferensbidrag (refereegranskat)abstract
- Objective: To examine the frequency of pain-related TMD in Saudi Arabians 20 to 40years old referred to a d specialist clinic in Makka. Materials and Methods: 325 referred patients (135 males, 190 females) filled in history questionnaires. Patients reporting pain-related TMD were clinically examined. The history and clinical examinations were performed according to an Arabic version of RDC/TMD Axis I and Axis II (Dworkin et al 1992). Results: All patients had a male-female ratio of 1:1.4. TMD pain patients were found to be 18% (n=58), out of which 46 were clinically examined. The 46 TMD pain patients had a mean age of 30 years (±7) with a male-female ratio of 1:6. All TMD pain patients had a diagnosis of myofascial pain and 66% had diagnoses of arthrogenous origin. The graded chronic pain was reported to be grade I in 45%, grade II in 53%. Axis II assessment of psychological status showed that 38% of the TMD pain patients yielded severe depression scores and 60% high nonspecific physical symptom scores. Conclusion: The present study showed a high frequency of TMD pain in this Saudi Arabian cohort and 18% of the patients met criteria for subdiagnoses of TMD. Depression and somatization according to SCL-90R had significantly higher scores in the pain group compared to the non-pain group. The high frequency of pain-related TMD found among the patients referred to specialized dental clinics should make health planners considering TMD/orofacial pain as specialty in dentistry in Saudi Arabia.
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| 5. |
- Al-Bishri, Awwad
(författare)
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Factors affecting neurosensory disturbances after mandibular osteotomies. Clinical and experimental studies
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Sensibilitetsnedsättning är en vanlig komplikation till kirurgisk korrigering av käkställningsfel i mandibeln speciellt vid användande av sagittal split teknik. Med denna teknik är risken för skada av n. alveolaris inferior stor och skadan kan ske direkt under det kirurgiska ingreppet eller genom att nerven blir inklämd mellan de olika benfragmenten. Frekvensen av sensibilitetsnedsättning efter sagittal split osteotomi varierar avsevärt mellan olika kirurgiska centra. Som ett alternativ till sagittal split osteotomi (SSO) kan intraoral vertikal ramus osteotomi (IVRO) användas för korrigering av mandibulär prognati. Fördelen med denna metod är den låga förekomsten av nervskada, som kompenserar den postoperativa intermaxillära fixationen. Kliniska studier genomfördes för att utvärdera NSD med hänsyn till olika kirurgiska metoder, riktning åt vilken mandibeln förflyttas under ingreppet, kombination med hakplastik, ålder, kön och användning av steroider perioperativt. Medan mandibelns förflyttningsriktning, hakplastik och kön inte påverkar frekvensen av NSD, förefaller verkar åldern samt användning av steroider perioperativt vara de faktorer att beakta. Som förväntat var förekomsten av NSD lägre med IVRO än med SSO. Dessutom var NSD jämförelsevis lägre när steroider gavs perioperativt. Införandet av steroider perioperativt sammanföll med minskad förekomst av NSD. Denna iakttagelse föranledde studier för att klargöra steroidernas roll. Det har visat att steroider befrämjar nervläkning så som den återspeglas i funktionella test och morfologiska förändringar [recruited macrophages och nerve growth factors (NGF-R p75)]
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| 6. |
- Al-Bishri, Awwad, et al.
(författare)
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Neurosensory disturbance after sagittal split and intraoral vertical ramus osteotomy : as reported in questionnaires and patients' records
- 2005
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Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier BV. - 0901-5027 .- 1399-0020. ; 34:3, s. 247-251
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This retrospective study aimed at evaluating the long-term incidence of neurosensory disturbance (NSD) after sagittal split osteotomy (SSO) and intraoral vertical ramus osteotomy (IVRO). Furthermore, a comparison was made between the results obtained by questionnaires and information in the patient records in the evaluation of nerve function. Finally, the degree of discomfort caused by the NSD was evaluated. One hundred and twentynine patients, who underwent IVRO (79 patients) and SSO (50 patients), were included. Questionnaires were mailed to the patients at least one year after the operation. The records of all patients, who returned the questionnaires, were reviewed. The results of NSD obtained by questionnaires and records differed indicating a disagreement between the judgement of the surgeon and the patient's opinion. Long lasting NSD was underestimated by the surgeon as compared to the patient's subjective symptom. Long lasting NSD was reported in 7.5% (questionnaire), 3.8% (record) after IVRO and in 11.6% (questionnaire) and 8.1% (record) after SSO.
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| 7. |
- Al-Bishri, Awwad, et al.
(författare)
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On neurosensory disturbance after sagittal split osteotomy
- 2004
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Ingår i: Journal of oral and maxillofacial surgery (Print). - : Elsevier BV. - 0278-2391 .- 1531-5053. ; 62:12, s. 1472-1476
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The purpose of this retrospective study was to assess the incidence of the neurosensory disturbance (NSD) after sagittal split osteotomy and evaluate NSD in relation to patient age, gender, satisfaction, and effect of steroids. PATIENTS AND METHODS: Questionnaires were mailed to all patients (31 women, 19 men) who underwent bilateral sagittal split osteotomy between 1995 and 1999, at least 1 year after the operation. Patients were queried about perceived NSD in the distribution of both inferior alveolar and lingual nerves, duration of these changes, and any influence of these changes on their quality of life. RESULTS: Eightysix percent of the mailed questionnaires were returned and analyzed (27 women, 16 men). Eight patients with 10 affected sides (11.6% of sides) reported long lasting NSD correspond-ing to the distribution of the inferior alveolar nerve. NSD was re-ported in 16.7% of the operated sides in women, while 3% of the operated sides in the men had such changes. Fifty percent of the operated sides in patients over 40 years of age were affected. Steroid treatment seemed to decrease NSD. Four patients (9%) were not satisfied, but only 1 attributed the dissatisfaction to sensory impairment. CONCLUSION: The incidence of NSD after sagittal split osteotomy in-creases in patients over the age of 40. Steroid regimen might be beneficial in reducing NSD after sagittal split osteotomy, although further investigation is required. The discomfort of the nerve damage seems outweighed by the result of function and esthetics.
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