SwePub - sökning: WFRF:(Albertsson A. C.)

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1.	2017 swepub:Mat__t
2.	Guillevin, L, et al. (författare) Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry 2013 Ingår i: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - 0392-856X. ; 31:2, s. S71-S80 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
3.	Malinverni, C, et al. (författare) Outcomes of younger patients with mantle-cell lymphoma experiencing late relapse (>24 months): the LATE-POD study 2024 Ingår i: Blood. - 1528-0020. Tidskriftsartikel (refereegranskat)
4.	Cox, D. M., et al. (författare) Spectroscopy along flerovium decay chains. II. Fine structure in odd-A 289Fl 2023 Ingår i: Physical Review C. - 2469-9985. ; 107:2 Tidskriftsartikel (refereegranskat)abstract Fifteen correlated α-decay chains starting from the odd-A superheavy nucleus 289Fl were observed following the fusion-evaporation reaction 48Ca+244Pu. The results call for at least two parallel α-decay sequences starting from at least two different states of 289Fl. This implies that close-lying levels in nuclei along these chains have quite different spin-parity assignments. Further, observed α-electron and α-photon coincidences, as well as the α-decay fine structure along the decay chains, suggest a change in the ground-state spin assignment between 285Cn and 281Ds. Our experimental results, on the excited level structure of the heaviest odd-N nuclei to date, provide a direct testing ground for theory. This is illustrated by comparison with new nuclear structure calculations based on the symmetry-conserving configuration mixing theory.
5.	Donaldson, M., et al. (författare) Optimal Pubertal Induction in Girls with Turner Syndrome Using Either Oral or Transdermal Estradiol: A Proposed Modern Strategy 2019 Ingår i: Hormone Research in Paediatrics. - : S. Karger AG. - 1663-2818 .- 1663-2826. ; 91:3, s. 153-163 Tidskriftsartikel (refereegranskat)abstract Background: Most girls with Turner syndrome (TS) require pubertal induction with estrogen, followed by long term replacement. However, no adequately powered prospective studies comparing transdermal with oral 17 beta-estradiol administration exist. This reflects the difficulty of securing funding to study a rare condition with relatively low morbidity/mortality when competing against conditions such as cancer and vascular disease. Protocol Consensus: The TS Working Group of the European Society for Paediatric Endocrinology (ESPE) has agreed to both a 3-year oral and a 3-year transdermal regimen for pubertal induction. Prerequisites include suitable 17 beta-estradiol tablets and matrix patches to allow the delivery of incremental doses based on body weight. Study Proposal: An international prospective cohort study with single centre analysis is proposed in which clinicians and families are invited to choose either of the agreed regimens, usually starting at 11 years. We hypothesise that pubertal induction with transdermal estradiol will result in better outcomes for some key parameters. The primary outcome measure chosen is height gain during the induction period. Analysis: Assessment of the demographics and drop-out rates of patients choosing either oral or transdermal preparations; and appropriate analysis of outcomes including pubertal height gain, final height, liver enzyme and lipid profile, adherence/acceptability, cardiovascular health, including systolic and diastolic blood pressure and aortic root diameter and bone health. Conclusion: The proposed model of prospective data collection according to internationally agreed protocols aims to break the current impasse in obtaining evidence-based management for TS and could be applied to other rare paediatric endocrine conditions. (C) 2019 S. Karger AG, Basel
6.	Savendahl, L., et al. (författare) Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study 2020 Ingår i: Lancet Diabetes & Endocrinology. - : Elsevier BV. - 2213-8587. ; 8:8, s. 683-692 Tidskriftsartikel (refereegranskat)abstract Background Recombinant human growth hormone has been used for more than 30 years and its indications have increased worldwide. There is concern that this treatment might increase mortality, but published data are scarce. We present data from the entire dataset of all eight countries of the Safety and Appropriateness of Growth hormone treatments in Europe (SAGhE) consortium, with the aim of studying long-term overall and cause-specific mortality in young adult patients treated with recombinant human growth hormone during childhood and relating this to the underlying diagnosis. Methods This cohort study was done in eight European countries (Belgium, France, Germany, Italy, The Netherlands, Sweden, Switzerland, and the UK). Patients were classified a priori based on pre-treatment perceived mortality risk from their underlying disease and followed up for cause-specific mortality. Person-years at risk of mortality and expected rates from general population data were used to calculate standardised mortality ratios (SMRs). Findings The cohort comprised 24 232 patients treated with recombinant human growth hormone during childhood, with more than 400 000 patient-years of follow-up. In low-risk patients with isolated growth hormone deficiency or idiopathic short stature, all-cause mortality was not significantly increased (SMR 1.1, 95% CI 0.9-1.3). In children born small for gestational age, all-cause mortality was significantly increased when analysed for all countries (SMR 1.5, CI 1.1-1.9), but this result was driven by the French subcohort. In patients at moderate or high risk, mortality was increased (SMR 3.8, 3.3-4.4; and 17.1, 15.6-18.7, respectively). Mortality was not associated with mean daily or cumulative doses of recombinant human growth hormone for any of the risk groups. Cause-specific mortality from diseases of the circulatory and haematological systems was increased in all risk groups. Interpretation In this cohort, the largest, to our knowledge, with long-term follow-up of patients treated with recombinant human growth hormone during childhood, all-cause mortality was associated with underlying diagnosis. In patients with isolated growth hormone deficiency or idiopathic short stature, recombinant human growth hormone treatment was not associated with increased all-cause mortality. However, mortality from certain causes was increased, emphasising the need for further long-term surveillance. Copyright (C) 2020 Elsevier Ltd. All rights reserved.
7.	Såmark-Roth, A., et al. (författare) Spectroscopy along flerovium decay chains. III. Details on experiment, analysis, 282Cn, and spontaneous fission branches 2023 Ingår i: Physical Review C. - 2469-9985. ; 107:2 Tidskriftsartikel (refereegranskat)abstract Flerovium isotopes (element Z = 114) were produced in the fusion-evaporation reactions 48Ca+242,244Pu and studied with an upgraded TASISpec decay station placed in the focal plane of the gas-filled separator TASCA at the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. Twenty-nine flerovium decay chains were identified by means of correlated implantation, α decay, and spontaneous fission events. Data analysis aspects and statistical assessments, primarily based on measured rates of various events, which laid the foundation for the comprehensive spectroscopic information on the flerovium decay chains, are presented in detail. Various decay scenarios of an excited state observed in 282Cn are examined in depth with the help of GEANT4 simulations and assessed by predictions of beyond mean-field calculations including triaxial shape degrees of freedom. Previous, revised, and newly derived fission probabilities of even-even superheavy nuclei are compared with various theoretical predictions.
8.	Dauber, A., et al. (författare) A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness 2020 Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 105:10, s. 3203-3214 Tidskriftsartikel (refereegranskat)abstract CONTEXT: Individual patients vary in their response to growth hormone (GH). No large-scale genome-wide studies have looked for genetic predictors of GH responsiveness. OBJECTIVE: To identify genetic variants associated with GH responsiveness. DESIGN: Genome-wide association study (GWAS). SETTING: Cohorts from multiple academic centers and a clinical trial. PATIENTS: A total of 614 individuals from 5 short stature cohorts receiving GH: 297 with idiopathic short stature, 276 with isolated GH deficiency, and 65 born small for gestational age. INTERVENTION: Association of more than 2 million variants was tested. MAIN OUTCOME MEASURES: Primary analysis: individual single nucleotide polymorphism (SNP) association with first-year change in height standard deviation scores. Secondary analyses: SNP associations in clinical subgroups adjusted for clinical variables; association of polygenic score calculated from 697 genome-wide significant height SNPs with GH responsiveness. RESULTS: No common variant associations reached genome-wide significance in the primary analysis. The strongest suggestive signals were found near the B4GALT4 and TBCE genes. After meta-analysis including replication data, signals at several loci reached or retained genome-wide significance in secondary analyses, including variants near ST3GAL6. There was no significant association with variants previously reported to be associated with GH response nor with a polygenic predicted height score. CONCLUSIONS: We performed the largest GWAS of GH responsiveness to date. We identified 2 loci with a suggestive effect on GH responsiveness in our primary analysis and several genome-wide significant associations in secondary analyses that require further replication. Our results are consistent with a polygenic component to GH responsiveness, likely distinct from the genetic regulators of adult height. © Endocrine Society 2020.
9.	Barnes, A. T., et al. (författare) LEGO - II. A 3mm molecular line study covering 100 pc of one of the most actively star-forming portions within the Milky Way disc 2020 Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 497:2, s. 1972-2001 Tidskriftsartikel (refereegranskat)abstract The current generation of (sub)mm-telescopes has allowed molecular line emission to become a major tool for studying the physical, kinematic, and chemical properties of extragalactic systems, yet exploiting these observations requires a detailed understanding of where emission lines originate within the Milky Way. In this paper, we present 60'' (similar to 3pc) resolution observations of many 3mm-band molecular lines across a large map of the W49 massive star-forming region (similar to 100x100pc at 11kpc), which were taken as part of the 'LEGO' IRAM-30m large project. We find that the spatial extent or brightness of the molecular line transitions are not well correlated with their critical densities, highlighting abundance and optical depth must be considered when estimating line emission characteristics. We explore how the total emission and emission efficiency (i.e. line brightness per H-2 column density) of the line emission vary as a function of molecular hydrogen column density and dust temperature. We find that there is not a single region of this parameter space responsible for the brightest and most efficiently emitting gas for all species. For example, we find that the HCN transition shows high emission efficiency at high column density (10(22)cm(-2)) and moderate temperatures (35K), whilst e.g. N2H+ emits most efficiently towards lower temperatures (10(22)cm(-2); <20K). We determine XCO(1-0)similar to 0.3 x 10(20)cm(-2)(Kkms(-1))(-1), and alpha(HCN(1-0))similar to 30M(circle dot)(Kkms(-1)pc(2))(-1), which both differ significantly from the commonly adopted values. In all, these results suggest caution should be taken when interpreting molecular line emission.
10.	Bjorn, A., et al. (författare) Review of life-cycle based methods for absolute environmental sustainability assessment and their applications 2020 Ingår i: Environmental Research Letters. - : IOP Publishing Ltd. - 1748-9326 .- 1748-9318. ; 15:8 Tidskriftsartikel (refereegranskat)abstract In many regions and at the planetary scale, human pressures on the environment exceed levels that natural systems can sustain. These pressures are caused by networks of human activities, which often extend across countries and continents due to global trade. This has led to an increasing requirement for methods that enable absolute environmental sustainability assessment (AESA) of anthropogenic systems and which have a basis in life cycle assessment (LCA). Such methods enable the comparison of environmental impacts of products, companies, nations, etc, with an assigned share of environmental carrying capacity for various impact categories. This study is the first systematic review of LCA-based AESA methods and their applications. After developing a framework for LCA-based AESA methods, we identified 45 relevant studies through an initial survey, database searches and citation analysis. We characterized these studies according to their intended application, impact categories, basis of carrying capacity estimates, spatial differentiation of environmental model and principles for assigning carrying capacity. We then characterized all method applications and synthesized their results. Based on this assessment, we present recommendations to practitioners on the selection and use of existing LCA-based AESA methods, as well as ways to perform assessments and communicate results to decision-makers. Furthermore, we identify future research priorities intended to extend coverage of all components of the proposed method framework, improve modeling and increase the applicability of methods. © 2020 The Author(s).
11.	Hochberg, Z., et al. (författare) Child health, developmental plasticity, and epigenetic programming 2011 Ingår i: Endocrine reviews. - : The Endocrine Society. - 0163-769X .- 1945-7189. ; 32:2, s. 159-224 Forskningsöversikt (refereegranskat)abstract Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.
12.	Mancini, M. C., et al. (författare) Effect of gastric bypass on spontaneous growth hormone and ghrelin release profiles 2006 Ingår i: Obesity (Silver Spring). ; 14:3, s. 383-7 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE: The purpose of this study was to analyze growth hormone (GH) concentrations in obese women before and after Roux-en-Y gastric bypass (RYGBP) and how resulting changes in weight, fat mass, ghrelin levels, and insulin sensitivity affect GH secretion. RESEARCH METHODS AND PROCEDURES: Blood was sampled at 20-minute intervals for 24 hours in 10 non-diabetic premenopausal severely obese women before and 6 months after RYGBP. GH concentrations were measured in all samples, and serum ghrelin was collected at five time-points. RESULTS: After a 27% BMI drop (55.9 +/- 6.2 to 40.7 +/- 5.8 kg/m(2)), blunted GH profiles underwent partial recovery. Basal, postprandial, and mean ghrelin concentrations were not changed. A negative correlation was found between mean GH levels and insulin and homeostasis model assessment (p < 0.01). BMI accounted for 54% of GH variation. DISCUSSION: Partial recovery of GH secretion after RYGBP-induced weight loss suggests that a blunted secretion is not a causal factor of obesity but a consequence of the obese state and does not seem to be ghrelin-level dependent.
13.	Nilsson, K O, et al. (författare) Improved final height in girls with Turner's syndrome treated with growth hormone and oxandrolone. 1996 Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 81, s. 635- Tidskriftsartikel (refereegranskat)abstract The spontaneous growth process in Turner's syndrome is characterized by a progressive decline in height velocity during childhood and no pubertal growth spurt. Therefore, therapy aimed at improving height during childhood as well as increasing final height is desirable for most girls with Turner's syndrome. Forty-five girls with Turner's syndrome, 9-16 yr of age (mean age, 12.2 yr), were allocated to three study groups. Group 1 (n = 13) was initially treated with oxandrolone alone; after 1 yr of treatment, GH without (group 1a; n = 6) or with (group 1b; n = 7) ethinyl estradiol was added. Group 2 (n = 17) was treated with GH plus oxandrolone. Group 3 (n = 15) was treated with GH, oxandrolone, and ethinyl estradiol. The dosage were: GH, 0.1 IU/kg.day; oxandrolone, 0.05 mg/kg.day; and ethinyl estradiol, 100 ng/kg.day. A height of 150 cm or more was achieved in 61%, 75%, and 60% of the girls in groups 1, 2, and 3, respectively. The most impressive increase in height was seen in group 2. In this group the mean final height was 154.2 cm (SD = 6.6), which is equivalent to a mean net gain of 8.5 cm (SD = 4.6) over the projected final height. In group 3, in which ethinyl estradiol was included from the start of therapy, the initially good height velocity decelerated after 1-2 yr of treatment. Their mean final height was 151.1 (SD = 4.6) cm, equivalent to a mean net gain of 3.0 cm (SD = 3.8). A similar growth-decelerating effect of ethinyl estradiol was seen in group 1b. We conclude that in girls with Turner's syndrome who are older than 9 yr of age, treatment with GH in combination with oxandrolone results in significant growth acceleration, imitating that in normal puberty, leading to a more favorable height during childhood. This mode of treatment also results in a significantly increased final height, permitting a great number of the girls to attain a final height of more than 150 cm. However, early addition of estrogen decelerates the height velocity and reduces the gain in height.
14.	Wit, J M., et al. (författare) Personalized Approach to Growth Hormone Treatment: Clinical Use of Growth Prediction Models 2013 Ingår i: Hormone Research in Paediatrics. - : Karger. - 1663-2818 .- 1663-2826. ; 79:5, s. 257-270 Forskningsöversikt (refereegranskat)abstract The goal of growth hormone (GH) treatment in a short child is to attain a fast catch-up growth toward the target height (TH) standard deviation score (SDS), followed by a maintenance phase, a proper pubertal height gain, and an adult height close to TH. The short-term response variable of GH treatment, first-year height velocity (HV) (cm/year or change in height SDS), can either be compared with GH response charts for diagnosis, age and gender, or with predicted HV based on prediction models. Three types of prediction models have been described: the Kabi International Growth Hormone Study models, the Gothenburg models and the Cologne model. With these models, 50-80% of the variance could be explained. When used prospectively, individualized dosing reduces the variation in growth response in comparison with a fixed dose per body weight. Insulin-like growth factor-I-based dose titration also led to a decrease in the variation. It is uncertain whether adding biochemical, genetic or proteomic markers may improve the accuracy of the prediction. Prediction models may lead to a more evidence-based approach to determine the GH dose regimen and may reduce the drug costs for GH treatment. There is a need for user-friendly software programs to make prediction models easily available in the clinic.
15.	Carlsson, A., et al. (författare) Prevalence of coeliac disease in Turner syndrome 1999 Ingår i: Acta Pædiatrica. - 1651-2227 .- 0803-5253. ; 88, s. 933- Tidskriftsartikel (refereegranskat)abstract This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA- antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were either AGA- or EMA-positive and further investigated with intestinal biopsy, four manifested villous atrophy (i.e. all three of the EMA-positive patients, but only one of the seven AGA- positive patients). The results suggest EMA-positivity to be a good immunological marker for use in screening for coeliac disease, and such screening to be justified in patients with Turner syndrome.
16.	Deming, Timothy J., et al. (författare) Polymers at the Interface with Biology 2018 Ingår i: Biomacromolecules. - : AMER CHEMICAL SOC. - 1525-7797 .- 1526-4602. ; 19:8, s. 3151-3162 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
17.	Maghnie, M., et al. (författare) Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort 2022 Ingår i: Journal of Clinical Endocrinology & Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 107:12, s. 3287-3301 Tidskriftsartikel (refereegranskat)abstract Context The Kabi/Pfizer International Growth Database (KIGS) is a large, international database (1987-2012) of children treated with recombinant human growth hormone (rhGH) in real-world settings. Objective This work aimed to evaluate the safety and efficacy of rhGH from the full KIGS cohort. Methods Data were collected by investigators from children with growth disorders treated with rhGH (Genotropin [somatropin]; Pfizer). Safety was evaluated in all treated patients, and efficacy in those treated for 1 year or more. A subgroup included patients treated for 5 years or more (>= 2 years prepubertal) who had reached near-adult height (NAH). Main outcomes included adverse events (AEs), serious AEs (SAEs), and height growth. Results The full KIGS cohort (N = 83 803 [58% male]) was treated for idiopathic GH deficiency (IGHD; 46.9%), organic GHD (10.0%), small for gestational age (SGA; 9.5%), Turner syndrome (TS; 9.2%), idiopathic short stature (ISS; 8.2%), and others (16.2%). Median rhGH treatment duration was 2.7 years and observation 3.1 years. SAEs occurred in 3.7% of patients and death in 0.4%. The most common SAEs were recurrence of craniopharyngioma (n = 151), neoplasm (n = 99), and cancer (n = 91); and scoliosis (n = 91). Median first-year delta height-SD score (SDS) (Prader) in prepubertal patients was 0.66 (IGHD), 0.55 (ISS), 0.58 (TS), and 0.71 (SGA). Median gains in NAH-SDS were 1.79 (IGHD), 1.37 (ISS), and 1.34 (SGA) for boys, and 2.07 (IGHD), 1.62 (ISS), 1.07 (TS), and 1.57 (SGA) for girls. Conclusion Data from KIGS, the largest and longest running international database of rhGH-treated children, show that rhGH is safe and increases short-term height gain and adult height across GHD and non-GHD conditions.
18.	Nilsson, KO, et al. (författare) Growth promoting treatment in girls with Turner syndrome : final height results according to three different Turner syndrome growth standards 1995 Ingår i: In: Albertsson-Wikland, K and Ranke, M (eds) Turner syndrome in a Life-Span Perspective. - : Elsevier Science B.V. ; , s. 89- Bokkapitel (övrigt vetenskapligt/konstnärligt)
19.	Nilsson, M. P., et al. (författare) Nordic anal cancer (NOAC) group consensus guidelines for risk-adapted delineation of the elective clinical target volume in anal cancer 2023 Ingår i: Acta Oncologica. - 0284-186X. ; 62:8, s. 897-906 Tidskriftsartikel (refereegranskat)abstract Background: To date, anal cancer patients are treated with radiotherapy to similar volumes despite a marked difference in risk profile based on tumor location and stage. A more individualized approach to delineation of the elective clinical target volume (CTVe) could potentially provide better oncological outcomes as well as improved quality of life. The aim of the present work was to establish Nordic Anal Cancer (NOAC) group guidelines for delineation of the CTVe in anal cancer.Methods: First, 12 radiation oncologists reviewed the literature in one of the following four areas: (1) previous delineation guidelines; (2) patterns of recurrence; (3) anatomical studies; (4) common iliac and para-aortic recurrences and delineation guidelines. Second, areas of controversy were identified and discussed with the aim of reaching consensus.Results: We present consensus-based recommendations for CTVe delineation in anal cancer regarding (a) which regions to include, and (b) how the regions should be delineated. Some of our recommendations deviate from current international guidelines. For instance, the posterolateral part of the inguinal region is excluded, decreasing the volume of irradiated normal tissue. For the external iliac region and the cranial border of the CTVe, we agreed on specifying two different recommendations, both considered acceptable. One of these recommendations is novel and risk-adapted; the external iliac region is omitted for low-risk patients, and several different cranial borders are used depending on the individual level of risk.Conclusion: We present NOAC consensus guidelines for delineation of the CTVe in anal cancer, including a risk-adapted strategy.
20.	Såmark-Roth, Anton, et al. (författare) Spectroscopy along flerovium decay chains: Discovery of 280Ds and an excited state in 282Cn 2021 Ingår i: Physical Review Letters. - 1079-7114. ; 126:3 Tidskriftsartikel (refereegranskat)abstract A nuclear spectroscopy experiment was conducted to study α-decay chains stemming from isotopes of flerovium (element Z=114). An upgraded TASISpec decay station was placed behind the gas-filled separator TASCA at the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. The fusion-evaporation reactions 48Ca+242Pu and 48Ca+244Pu provided a total of 32 flerovium-candidate decay chains, of which two and eleven were firmly assigned to 286Fl and 288Fl, respectively. A prompt coincidence between a 9.60(1)-MeV α-particle event and a 0.36(1)-MeV conversion electron marked the first observation of an excited state in an even-even isotope of the heaviest man-made elements, namely 282Cn. Spectroscopy of 288Fl decay chains fixed Qα=10.06(1) MeV. In one case, a Qα=9.46(1)-MeV decay from 284Cn into 280Ds was observed, with 280Ds fissioning after only 518 μs. The impact of these findings, aggregated with existing data on decay chains of 286,288Fl, on the size of an anticipated shell gap at proton number Z=114 is discussed in light of predictions from two beyond-mean-field calculations, which take into account triaxial deformation.
21.	Albertsson, A-C., et al. (författare) Degradation of enhanced environmentally degradable polyethylene in biological aqueous media: mechanisms during the first stages 1994 Ingår i: Journal of Applied Polymer Science. - 0021-8995 .- 1097-4628. ; 51:6, s. 1097-1105 Tidskriftsartikel (refereegranskat)
22.	Albertsson, A-C., et al. (författare) Degradation product pattern and morphology changes as means to differentiate abiotically and biotically aged degradable polyethylene 1995 Ingår i: Polymer. - 0032-3861 .- 1873-2291. ; 36:16, s. 3075-83 Tidskriftsartikel (refereegranskat)
23.	Albertsson, A-C., et al. (författare) Increased biodegradation of a low-density polyethylene (LDPE) matrix in starch-filled LDPE materials 1993 Ingår i: Journal of environmental polymer degradation. - 1064-7546 .- 1572-8900. ; 1:4, s. 241-245 Tidskriftsartikel (refereegranskat)
24.	Albertsson, A-C., et al. (författare) Increased biodegradation of low-density polyethylene (LDPE) with nonionic surfactant 1993 Ingår i: Acta Polymerica. - 0323-7648 .- 1521-4044. ; 44:5, s. 243-246 Tidskriftsartikel (refereegranskat)
25.	Albertsson, A-C., et al. (författare) Solid-phase extraction and gas chromatographic-mass spectrometric identification of degradation products from enhanced environmentally degradable polyethylene 1995 Ingår i: Journal of Chromatography A. - 0021-9673 .- 1873-3778. ; 690:2, s. 207-217 Tidskriftsartikel (refereegranskat)
26.	Albertsson, A-C., et al. (författare) Susceptibility of enhanced environmentally degradable polyethylene to thermal and photo-oxidation 1992 Ingår i: Polymer degradation and stability. - 0141-3910 .- 1873-2321. ; 37:2, s. 163-171 Tidskriftsartikel (refereegranskat)
27.	Boguszewski, M. C., et al. (författare) Insulin-like growth factor-1, leptin, body composition, and clinical status interactions in children with cystic fibrosis 2007 Ingår i: Horm Res. - : S. Karger AG. - 0301-0163. ; 67:5, s. 250-6 Tidskriftsartikel (refereegranskat)abstract BACKGROUND/AIMS: Children with cystic fibrosis (CF) are of increased risk of reduced fat body mass (FBM) and lean body mass (LBM). Serum concentrations of insulin-like growth factor-1 (IGF-1)and leptin could be markers of LBM and/or FBM depletion. To evaluate the relationships between disease activity, body composition, IGF-1 and leptin concentrations in CF children. METHODS: A cross-sectional study with 26 CF children aged 5.0-15.5 years and 33 healthy controls, mean age 9.4 years. Body composition was evaluated by dual-energy X-ray absorptiometry. Fasting blood samples were analyzed for leptin, IGF-1 and IGFBP-3. RESULTS: FBM standard deviation score (SDS; CF boys -0.02 +/- 0.88 vs. 0.78 +/- 0.65, p < 0.01; CF girls -0.37 +/- 1.15 vs. 0.70 +/- 0.97, p < 0.05), leptin concentration (CF boys 2.07 +/- 0.79 vs. 3.07 +/- 1.28 ng/ml, p < 0.05; CF girls 2.71 +/- 0.86 vs. 5.00 +/- 2.95 ng/ml, p < 0.05) and IGF-1SDS (CF boys -1.43 +/- 1.50 vs. -0.32 +/- 0.88, p < 0.05; CF girls -0.66 +/- 1.66 vs. 0.64 +/- 0.57, p < 0.01) were lower in CF children compared to controls. Shwachman score was the strongest predictor of lean body mass (R = 0.63). Leptin levels explain 60% of the variability in FBM. CONCLUSION: Serum concentrations of IGF-1 and leptin are decreased in children with CF and are associated with clinical conditions and body composition.
28.	Darendeliler, F., et al. (författare) Bone Age Progression during the First Year of Growth Hormone Therapy in Pre-Pubertal Children with Idiopathic Growth Hormone Deficiency, Turner Syndrome or Idiopathic Short Stature, and in Short Children Born Small for Gestational Age: Analysis of Data from KIGS (Pfizer International Growth Database) 2005 Ingår i: Horm Res. ; 63:1, s. 40-7 Tidskriftsartikel (refereegranskat)abstract Background/Aims: The beneficial effects of growth hormone (GH) therapy on statural growth in children are well established, but the effects on skeletal maturation are less clear. The progression of bone age (BA) was therefore studied during the first year of GH treatment in pre-pubertal children with idiopathic GH deficiency (GHD), Turner syndrome (TS) or idiopathic short stature (ISS), and in short pre-pubertal children born small for gestational age (SGA). Methods: Cross-sectional data on 2,209 short children with idiopathic GHD, 694 with TS, 569 with ISS and 153 with SGA were analysed. Longitudinal data were also analysed from 308 children with idiopathic GHD, 99 with TS, 57 with ISS and 29 with SGA. All patients included in the study were enrolled in KIGS (Pfizer International Growth Database) and were being treated with recombinant human GH (Genotropin((R))). BA was assessed using the Greulich and Pyle method at baseline and after 1 year of GH therapy. Results: In all groups of patients the mean progression of BA was 1 year during the year of GH therapy, although there was considerable individual variation. Progression of BA was not correlated with chronological age, BA, height SD score (SDS) or body mass index SDS at the onset of GH therapy. There was also no consistent effect of the GH dose on BA progression. Conclusion: Progression of BA appears to be normal in patients receiving GH in these diagnostic groups, at least over the first year of treatment in pre-puberty. Copyright (c) 2005 S. Karger AG, Basel.
29.	Dworeck, C, et al. (författare) Association of Pretreatment With P2Y12 Receptor Antagonists Preceding Percutaneous Coronary Intervention in Non-ST-Segment Elevation Acute Coronary Syndromes With Outcomes 2020 Ingår i: JAMA network open. - : American Medical Association (AMA). - 2574-3805. ; 3:10, s. e2018735- Tidskriftsartikel (refereegranskat)
30.	Eldsäter, C., et al. (författare) Impact of degradation mechanisms on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) during composting 1997 Ingår i: Acta Polymerica. - 0323-7648 .- 1521-4044. ; 48:11, s. 478-483 Tidskriftsartikel (refereegranskat)
31.	Eldsäter, C., et al. (författare) The biodegradation of amorphous and crystalline regions in film-blown poly(ε-caprolactone) 2000 Ingår i: Polymer. - 0032-3861 .- 1873-2291. ; 41:4, s. 1297-1304 Tidskriftsartikel (refereegranskat)
32.	Garrison, Julie A., 1993-, et al. (författare) Temporal and spatial changes in benthic invertebrate trophic networks along a taxonomic richness gradient 2022 Ingår i: Ecology and Evolution. - : Wiley. - 2045-7758. ; 12:6 Tidskriftsartikel (refereegranskat)abstract Species interactions underlie most ecosystem functions and are important for understanding ecosystem changes. Representing one type of species interaction, trophic networks were constructed from biodiversity monitoring data and known trophic links to assess how ecosystems have changed over time. The Baltic Sea is subject to many anthropogenic pressures, and low species diversity makes it an ideal candidate for determining how pressures change food webs. In this study, we used benthic monitoring data for 20 years (1980–1989 and 2010–2019) from the Swedish coast of the Baltic Sea and Skagerrak to investigate changes in benthic invertebrate trophic interactions. We constructed food webs and calculated fundamental food web metrics evaluating network horizontal and vertical diversity, as well as stability that were compared over space and time. Our results show that the west coast of Sweden (Skagerrak) suffered a reduction in benthic invertebrate biodiversity by 32% between the 1980s and 2010s, and that the number of links, generality of predators, and vulnerability of prey have been significantly reduced. The other basins (Bothnian Sea, Baltic Proper, and Bornholm Basin) do not show any significant changes in species richness or consistent significant trends in any food web metrics investigated, demonstrating resilience at a lower species diversity. The decreased complexity of the Skagerrak food webs indicates vulnerability to further perturbations and pressures should be limited as much as possible to ensure continued ecosystem functions.
33.	Hellstrom, A, et al. (författare) Postnatal serum insulin-like growth factor I deficiency is associated withretinopathy of prematurity and other complications of premature birth. 2003 Ingår i: Pediatrics. ; 112, s. 1016- Tidskriftsartikel (refereegranskat)
34.	Johnston, L. B., et al. (författare) Gene association studies in small for gestational age infants 2002 Ingår i: J Pediatr Endocrinol Metab. ; 15 Suppl 5 Tidskriftsartikel (refereegranskat)
35.	Karlsson, S., et al. (författare) Gas chromatographic, liquid chromatographic and gas chromatographic-mass spectrometric identification of degradation products in accelerated aged microbial polyhydroxyalkanoates 1994 Ingår i: Journal of Chromatography A. - 0021-9673 .- 1873-3778. ; 669:1-2, s. 97-102 Tidskriftsartikel (refereegranskat)
36.	Ohrlander, M., et al. (författare) The effect of electron beam irradiation on PCL and PDXO-X monitored by luminescence and electron spin resonance measurements 2000 Ingår i: Polymer. - 0032-3861 .- 1873-2291. ; 41:4, s. 1277-1286 Tidskriftsartikel (refereegranskat)abstract The effect of electron beam irradiation in air or argon was studied on two hydrolysable aliphatic polyesters, poly(e-caprolactone) (PCL) and chemically cross-linked poly(1,5-dioxepan-2-one) (PDXO-X). A secondary alkylether radical and a tertiary alkyl radical were identified by ESR in PCL and PDXO-X after irradiation in both air and argon. For the samples irradiated in air, peroxy radicals were detected in PCL but not in PDXO-X. For irradiated PCL, the intensities in the luminescence measurements seemed to be dose-dependent. Large amounts of oxidation products were found present in the PDXO-X irradiated in air and the luminescence intensities seemed to be dose-dependent.The effect of electron beam irradiation in air or argon was studied on two hydrolysable aliphatic polyesters, poly(e-caprolactone) (PCL) and chemically cross-linked poly(1,5-dioxepan-2-one) (PDXO-X). A secondary alkylether radical and tertiary alkyl radical were identified by ESR in PCL and PDXO-X after irradiation in both air and argon. For the samples irradiated in air, peroxy radicals were detected in PCL but not in PDXO-X. For irradiated PCL, the intensities in the luminescence measurements seemed to be dose-dependent. Large amounts of oxidation products were found present in the PDXO-X irradiated in air and the luminescence intensities seemed to be dose-dependent.
37.	Savendahl, L, et al. (författare) Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study 2020 Ingår i: The lancet. Diabetes & endocrinology. - 2213-8595. ; 8:8, s. 683-692 Tidskriftsartikel (refereegranskat)
38.	Sjoberg, J, et al. (författare) Utilization of hemicelluloses from forestry residual streams as barrier film and hydrogel materials. 2005 Ingår i: Abstracts of Papers of the American Chemical Society. - : AMER CHEMICAL SOC. - 0065-7727. ; 229, s. U286-U287 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
39.	Adingupu, D. D., et al. (författare) Radial artery intima-media thickness regresses after secondary prevention interventions in patients' post-acute coronary syndrome and is associated with cardiac and kidney biomarkers 2017 Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 8:32, s. 53419-53431 Tidskriftsartikel (refereegranskat)abstract Background: Radial artery intima-media thickness (rIMT) measured by ultra-high-resolution ultrasound is associated with increased cardiovascular risk and predicts outcomes. We performed non-invasive high-resolution ultrasound of the radial artery to investigate vascular changes in subjects presenting with acute coronary syndrome (ACS) and who had undergone percutaneous coronary intervention (PCI). Purpose: In the present work, we aimed to follow rIMT change over time post-acute coronary syndrome as a tool to monitor potential response to intensified medical therapy. Methods: We examined 256 subjects who underwent PCI due to ACS and healthy controls (n= 39) and we measured a number of biomarkers, which are known to be associated with cardiovascular disease. Images of radial artery were acquired bilaterally in the longitudinal view using a 50 MHz transducer (Vevo 2100 VisualSonics, Inc, Toronto, Ontario, Canada). Carotid IMT (cIMT) and rIMT were measured at <1 month after index PCI followed by a repeated measurement of rIMT at 4 months from the ACS in a sub-set (n= 117). Results: rIMT measured within 1 month post ACS was significantly higher than rIMT after 4 months from ACS, (p < 0.0001), mean +/- SD (rIMT right 0.35 +/- 0.08; rIMT left 0.37 +/- 0.08) vs. (rIMT right 0.29 +/- 0.08; rIMT left 0.31 +/- 0.09) respectively. There was no statistically significant change in cIMT. In healthy controls there were no changes in rIMT or cIMT overtime. High levels of CX3CL1 and myeloperoxidase measured within one month post ACS are associated with increase of rIMT, r=0.38 (p< 0.0001) and r=0.41 (p< 0.0001) respectively. Conclusions: rIMT seem to decrease systemically after ACS and is accompanied with corresponding biomarker change. The cause and clinical implications of the observed decrement in rIMT after ACS need further studies.
40.	Albertsson, A-C., et al. (författare) Abiotic degradation products from enhanced environmentally degradable polyethylene 1994 Ingår i: Acta Polymerica. - 0323-7648 .- 1521-4044. ; 45:2, s. 97-103 Tidskriftsartikel (refereegranskat)
41.	Albertsson, A-C., et al. (författare) Aspects of biodeterioration of inert and degradable polymers 1993 Ingår i: International Biodeterioration & Biodegradation. - 0964-8305 .- 1879-0208. ; 31:3, s. 161-170 Tidskriftsartikel (refereegranskat)
42.	Albertsson, A-C., et al. (författare) Biodegradable polymers 1992 Ingår i: Comprehensive Polymer Science, Supplement Series. - Midland, Michigan : Pergamon Press. ; , s. 285- Bokkapitel (refereegranskat)
43.	Albertsson, A-C., et al. (författare) Biodegradation and testmethods for environmental and biomedical applications of polymers 1990 Ingår i: Degradable Materials. - Boca Raton : CRC Press. ; , s. 263- Bokkapitel (refereegranskat)
44.	Albertsson, A-C., et al. (författare) Chemistry and biochemistry of polymer biodegradation 1994 Ingår i: Chemistry and Technology of Biodegradable Polymers. - London, England : Blackie Academic & Professional. ; , s. 7-17 Bokkapitel (refereegranskat)
45.	Albertsson, A-C., et al. (författare) Chromatographic fingerprinting as a means to predict degradation mechanisms 1996 Ingår i: Journal of environmental polymer degradation. - 1064-7546 .- 1572-8900. ; 4:1, s. 51-3 Tidskriftsartikel (refereegranskat)
46.	Albertsson, A-C., et al. (författare) Controlled degradation by artificial and biological processes 1996 Ingår i: Macromol. Design of Polymeric Materials. - : Marcel Dekker. ; , s. 54- Bokkapitel (refereegranskat)
47.	Albertsson, A-C., et al. (författare) Degradable polyethylene-starch complex 1991 Ingår i: Makromolekulare Chemie, Macromolecular Symposia. ; 48-49:Eur. Polym. Fed. Symp. Polym. Mater., 3rd, 1990, s. 395-402 Tidskriftsartikel (refereegranskat)
48.	Albertsson, A-C., et al. (författare) Degradable Polymers 1996 Ingår i: The Polymeric Materials Encyclopedia: Synthesis, Properties and Applications. - Boca Raton, USA : CRC Press. ; , s. 150- Bokkapitel (refereegranskat)
49.	Albertsson, A-C., et al. (författare) Degradable polymers for the future 1995 Ingår i: Acta Polymerica. - 0323-7648 .- 1521-4044. ; 46:2, s. 114-123 Tidskriftsartikel (refereegranskat)
50.	Albertsson, A-C., et al. (författare) Environment-adaptable polymers 1993 Ingår i: Polymer degradation and stability. - 0141-3910 .- 1873-2321. ; 41:3, s. 345-349 Tidskriftsartikel (refereegranskat)

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