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- Thomas, HS, et al.
(författare)
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- 2019
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| 2. |
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| 3. |
- Bravo, L, et al.
(författare)
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- 2021
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| 5. |
- Tabiri, S, et al.
(författare)
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- 2021
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| 11. |
- Kanai, M, et al.
(författare)
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- 2023
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| 12. |
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| 13. |
- Glasbey, JC, et al.
(författare)
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- 2021
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| 19. |
- Niemi, MEK, et al.
(författare)
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- 2021
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| 20. |
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| 22. |
- Mishra, A, et al.
(författare)
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Diminishing benefits of urban living for children and adolescents' growth and development
- 2023
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
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Tidskriftsartikel (refereegranskat)abstract
- Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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| 26. |
- Farnham, Andrea, et al.
(författare)
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Early career researchers want Open Science
- 2017
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Ingår i: Genome Biology. - : Springer Science and Business Media LLC. - 1474-7596 .- 1474-760X. ; 18:1
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Tidskriftsartikel (refereegranskat)abstract
- Open Science is encouraged by the European Union and many other political and scientific institutions. However, scientific practice is proving slow to change. We propose, as early career researchers, that it is our task to change scientific research into open scientific research and commit to Open Science principles.
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| 27. |
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| 28. |
- Güler, Rezan, et al.
(författare)
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VEGFR2-Specific Ligands Based on Affibody Molecules Demonstrate Agonistic Effects when Tetrameric in the Soluble Form or Immobilized via Spider Silk
- 2019
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Ingår i: ACS Biomaterials Science & Engineering. - : American Chemical Society (ACS). - 2373-9878. ; 5:12, s. 6474-6484
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Tidskriftsartikel (refereegranskat)abstract
- Strategies to promote vascularization are being developed in order to improve long-term survival of artificial tissue constructs. Vascular endothelial growth factor A (VEGFA) has an important role in both pathological and physiological angiogenesis, mediated by binding to VEGF receptors (VEGFRs). In nature, signaling can be modulated by presentation of growth factors in either soluble form or bound to the extracellular matrix. Herein, a previously reported VEGFR2-binding antagonistic affibody heterodimer (di-Z(VEGFR2)) was formatted into a tetrameric construct (tetra-Z(VEGFR2)) with the intention of generating artificial agonistic ligands for VEGFR2 signaling. In vitro cell assays demonstrated that tetra-Z(VEGFR2) induced VEGFR2 phosphorylation and increased cell proliferation, in contrast to di-Z(VEGFR2). In order to simulate matrix-bound factors, both constructs were fused at the genetic level to a partial spider silk protein, 4RepCT. Assembly of the silk fusion proteins onto a solid surface was verified by quartz crystal microbalance with dissipation analysis. Moreover, surface plasmon resonance studies demonstrated retained VEGFR2 binding ability of di-Z(VEGFR2) silk and tetra-Z(VEGFR2)-silk after silk-mediated immobilization. Cell culture studies demonstrated that VEGFR2-overexpressing cells adhered to di-Z(VEGFR2) -silk and tetra-Z(VEGFR2) -silk and had activated VEGFR2 signaling. Altogether, we demonstrate the potential of especially tetra-Z(VEGFR2)-silk to promote angiogenesis in tissue-engineering applications. The results from the study also show that molecules can obtain completely new functions when presented on materials, and verifying the biological effects after functionalizing materials is thus always recommended.
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| 32. |
- Samad, Ali, et al.
(författare)
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White Paper on Machine Learning in 6G Wireless Communication Networks : 6G Research Visions, No. 7, 2020
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This white paper discusses various topics, advances, and projections regarding machine learning (ML) in wireless communications. Sixth generation (6G) wireless communications networks will be the backbone of the digital transformation of societies by providing ubiquitous, reliable, and near-instant wireless connectivity for humans and machines. Recent advances in ML research have enabled a wide range of novel technologies such as self-driving vehicles and voice assistants. Such innovation is made possible by the availability of advanced ML models, large datasets, and high computational power. In addition, the ever-increasing demand for connectivity will require even more extensive innovation in 6G wireless networks. Consequently, ML tools will play a major role in solving the new problems in the wireless domain. In this paper, we offer a vision of how ML will impact wireless communications systems. We first provide an overview of the ML methods that have the highest potential to be used in wireless networks. We then discuss the problems that can be solved by using ML in various layers of the network such as the physical, medium-access, and application layers. Zero-touch optimization of wireless networks using ML is another interesting aspect discussed in this paper. Finally, at the end of each section, a set of important future research questions is presented.
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| 33. |
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| 35. |
- Aad, G, et al.
(författare)
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- 2015
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