| 1. |
- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 2. |
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| 5. |
- Tran, K. B., et al.
(författare)
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The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet. - 0140-6736. ; 400:10352, s. 563-591
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Tidskriftsartikel (refereegranskat)abstract
- Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 6. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 7. |
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| 8. |
- Muhammad, Noor, et al.
(författare)
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Novel mutations in MPT64 secretory protein of Mycobacterium tuberculosis complex
- 2023
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 20:3
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Tidskriftsartikel (refereegranskat)abstract
- Tuberculosis (TB) is a global health problem caused by the Mycobacterium tuberculosis complex (MTBC). These bacteria secrete various proteins involved in the pathogenesis and persistence of MTBC. Among the secretory proteins, MPT64 (Rv1980C) is highly conserved and is also known as a major culture filtrate that is used in rapid diagnosis of MTBC. In the current study, we aimed to find the mutation in this highly conserved protein in isolates from the Pashtun-dominant province of Pakistan. We analyzed 470 M. tuberculosis whole-genome sequences of Khyber Pakhtunkhwa Province. Mutations in the MPT64 gene were screened through TB-Profiler and BioEdit software tools. The DynaMut web server was used to analyze the impact of the mutation on protein dynamics and stability. Among 470 MTB genomes, three non-synonymous mutations were detected in nine isolates, and one synonymous mutation (G208A) was found in four isolates. Mutation G211T (F159L), which was detected at the C-terminal domain of the protein in six isolates, was the most prominent. The second novel mutation, T480C (I70V), was detected in two isolates at the C-terminal side of the protein structure. The third novel mutation, A491C (L66R), was detected in a single isolate at the N-terminal side of the MPT64 protein. The effect of these three mutations was destabilizing on the protein structure. The molecular flexibility of the first two mutations increased, and the last one decreased. MPT64 is a highly conserved secretory protein, harboring only a few mutations. This study provides useful information for better managing the diagnosis of MTB isolates in high TB-burden countries.
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| 9. |
- Khan, Kifayatullah, et al.
(författare)
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Heavy Metal Occurrence, Pathways, and Associated Socio-ecological Risks in Riverine Water : Application of Geographic Information System, Multivariate Statistics, and Risk Assessment Models
- 2023
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Ingår i: Water, Air and Soil Pollution. - 0049-6979 .- 1573-2932. ; 234:7
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Tidskriftsartikel (refereegranskat)abstract
- Heavy metal (HM) pollution is one of the major issues of concern in the world due to its serious health consequences on humans and ecology. In this study, riverine water from the River Kabul in Pakistan was studied using inductively coupled plasma mass spectrometry (ICP-MS) to determine the variation, routes, and possible socio-ecological hazards of chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn) cadmium (Cd), mercury (Hg), and lead (Pb). The results revealed significant HMs variation (p < 0.05) in the sequence of Cr > Zn > Ni > Cu > Cd > Pb > Mn > Co > Hg, indicating prevalent metal contaminations in the river. Multivariate statistics showed significant strong positive correlations (p ≤ 0.01) between the individual HMs contents along the monitoring sites. The strong-moderate levels of Cu, Co, Zn, Mn, Pb, and Cd in riverine systems were observed to be caused by surrounding industrial, agrochemicals, mining, and domestic wastewater discharges along with geogenic sources, the weak levels of Cr and Ni could be induced by erosion of mafic and ultramafic rocks, and mining activities, whereas the low contamination of Hg suggests minimal atmospheric deposition with fewer industrial discharges in the environment. The overall mass flux of the ∑HMs was estimated to be around 164.10 kg/year, with significant HM pollution index (HPI) and pollution index (PI) variations along the river characterizing the potential risk of HMs in decreasing order of Cd > Hg > Cr > Ni > Co > Pb > Mn > Cu > Zn and Cd > Hg > Ni > Pb > Cr > Co > Cu > Mn > Zn, respectively. Individual HM contamination was within the ecological risk threshold (ERI < 110), where, the chronic daily intake (CDIs), hazard quotients (HQs), health indices (HIs), and cancer risks (CRs) of Cd, Ni, Co, Cr, and Pb by daily riverine water ingestion and dermal contact posing considerable human health concerns. To protect the environment and public health, our findings suggest that untreated anthropogenic wastewater discharge into the river system be strictly controlled and regulated through public awareness campaigns and legislation prohibiting the use of herbicides and fertilizers containing high levels of Cr, Ni, Co, Cd, and Pb.
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| 10. |
- Abdulhadi, Nadia M. Noor, et al.
(författare)
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Doctors' and nurses' views on patient care for type 2 diabetes : an interview study in primary health care in Oman
- 2013
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Ingår i: Primary Health Care Research and Development. - : Cambridge University Press. - 1463-4236 .- 1477-1128. ; 14:3, s. 258-269
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Tidskriftsartikel (refereegranskat)abstract
- Aim: This study aimed at exploring the experiences of primary health-care providers of their encounters with patients with type 2 diabetes, and their preferences and suggestions for future improvement of diabetes care. Background: Barriers to good diabetes care could be related to problems from health-care providers' side, patients' side or the healthcare system of the country. Treatment of patients with type 2 diabetes has become a huge challenge in Oman, where the prevalence has increased to high levels. Method: Semi-structured interviews were conducted with 26 health-care professionals, 19 doctors and seven nurses, who worked in primary health care in Oman. Qualitative content analysis was applied. Findings: Organizational barriers and barriers related to patients and healthcare providers were identified. These included workload and lack of teamwork approach. Poor patients' management adherence and influence of culture on their attitudes towards illness were identified. From the providers' side, language barriers, providers' frustration and aggressive attitudes towards the patients were reflected. Decreasing the workload, availability of competent teams with diabetes specialist nurses and continuity of care were suggested. Furthermore, changing professional behaviours towards a more patient-centred approach and need for health education to the patients, especially on self-management, were addressed. Appropriate training for health-care providers in communication skills with emphasis on self-care education and individualization of care according to each patient's needs are important for improvement of diabetes care in Oman.
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| 11. |
- Ahmad, Iftikhar, et al.
(författare)
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Characterizing the role of vehicular cloud computing in road traffic management
- 2017
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Ingår i: International Journal of Distributed Sensor Networks. - : Sage Publications. - 1550-1329 .- 1550-1477. ; 13:5
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Tidskriftsartikel (refereegranskat)abstract
- Vehicular cloud computing is envisioned to deliver services that provide traffic safety and efficiency to vehicles. Vehicular cloud computing has great potential to change the contemporary vehicular communication paradigm. Explicitly, the underutilized resources of vehicles can be shared with other vehicles to manage traffic during congestion. These resources include but are not limited to storage, computing power, and Internet connectivity. This study reviews current traffic management systems to analyze the role and significance of vehicular cloud computing in road traffic management. First, an abstraction of the vehicular cloud infrastructure in an urban scenario is presented to explore the vehicular cloud computing process. A taxonomy of vehicular clouds that defines the cloud formation, integration types, and services is presented. A taxonomy of vehicular cloud services is also provided to explore the object types involved and their positions within the vehicular cloud. A comparison of the current state-of-the-art traffic management systems is performed in terms of parameters, such as vehicular ad hoc network infrastructure, Internet dependency, cloud management, scalability, traffic flow control, and emerging services. Potential future challenges and emerging technologies, such as the Internet of vehicles and its incorporation in traffic congestion control, are also discussed. Vehicular cloud computing is envisioned to have a substantial role in the development of smart traffic management solutions and in emerging Internet of vehicles
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| 12. |
- Ahmed, Ammar, et al.
(författare)
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Learning from the few : Fine-grained approach to pediatric wrist pathology recognition on a limited dataset
- 2024
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Ingår i: Computers in Biology and Medicine. - : Elsevier. - 0010-4825 .- 1879-0534. ; 181
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Tidskriftsartikel (refereegranskat)abstract
- Wrist pathologies, particularly fractures common among children and adolescents, present a critical diagnostic challenge. While X-ray imaging remains a prevalent diagnostic tool, the increasing misinterpretation rates highlight the need for more accurate analysis, especially considering the lack of specialized training among many surgeons and physicians. Recent advancements in deep convolutional neural networks offer promise in automating pathology detection in trauma X-rays. However, distinguishing subtle variations between pediatric wrist pathologies in X-rays remains challenging. Traditional manual annotation, though effective, is laborious, costly, and requires specialized expertise. In this paper, we address the challenge of pediatric wrist pathology recognition with a fine-grained approach, aimed at automatically identifying discriminative regions in X-rays without manual intervention. We refine our fine-grained architecture through ablation analysis and the integration of LION. Leveraging Grad-CAM, an explainable AI technique, we highlight these regions. Despite using limited data, reflective of real-world medical study constraints, our method consistently outperforms state-of-the-art image recognition models on both augmented and original (challenging) test sets. Our proposed refined architecture achieves an increase in accuracy of 1.06% and 1.25% compared to the baseline method, resulting in accuracies of 86% and 84%, respectively. Moreover, our approach demonstrates the highest fracture sensitivity of 97%, highlighting its potential to enhance wrist pathology recognition.
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| 13. |
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| 14. |
- Ali, Noor Adel Mohammed, et al.
(författare)
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Enamel demineralization around orthodontic brackets bonded with new bioactive composite (in-vitro study)
- 2024
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Ingår i: Journal of Baghdad College of Dentistry. - : Baghdad College of Dentistry. - 1817-1869 .- 2311-5270. ; 36:2, s. 54-62
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Tidskriftsartikel (refereegranskat)abstract
- Background: This study aimed to evaluate the effect of bioactive composite (ACTIVA) on enamel demineralisation when used as an orthodontic adhesive, compared to other adhesives.Materials and methods: Human upper premolars (n=64) were randomly divided into two equal groups; the first group stored the bonded teeth in deionised water for 30 days at 37°C, and the second group exposed the bonded teeth to acidic media. Each group was further subdivided into four subgroups, with eight premolars in each subgroup, based on the type of adhesive used to bond metal brackets: non-fluoride-releasing adhesive (Transbond XT), fluoride-releasing adhesive (Light Bond), light-cured, resin-reinforced glass ionomer (GC Fuji ortho LC), and bioactive restorative composite (ACTIVA BioACTIVE-RESTORATIVE). Enamel demineralisation was assessed at baseline and after 30 days with a laser fluorescence device (DIAGNOdent™ Pen).Results: There were significant differences in fluorescence variation values (ΔFV) among all four tested adhesive systems in both water and acid groups after 30 days. Light Bond adhesive showed the highest fluorescence variation value, while glass ionomer showed the lowest, indicating less enamel demineralisation around the bracket. ACTIVA had less enamel demineralisation in acidic media. However, there was no significant difference in enamel demineralisation between water storage and acidic media groups.Conclusion: ACTIVA (RMGIC + composite) exhibited less enamel demineralisation than Light Bond; however, Fuji ortho LC showed the lowest enamel demineralisation.
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| 15. |
- Asan, Noor Badariah, 1984-
(författare)
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Fat-IBC : A New Paradigm for Intra-body Communication
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In the last two decades, a significant development in the field of medical technology occurred worldwide. This development is characterized by the materialization of various body implants and worn devices, that is devices attached to the body. These devices assist doctors and paramedical staff in effectively monitoring the patient’s health and helping increase patients’ average life expectancy. Furthermore, the various implants inside the human body serve different purposes according to the humans’ needs. As this situation became more prominent, the development of protocols and of reliable transmission media is becomes essential to improve the efficiency of inter-device communications. Positive prospects of the use of human tissue for intra-body communication were proven in recent studies. Fat tissues, for example, which also work as energy banks for human beings, can be potentially used in intra-body communications as transmission media. In this thesis, the fat (adipose) tissue’s function as an intra-body communication channel was investigated. Therefore, various simulations and experimentations were performed in order to characterize the reliability of the fat tissue in terms of communication, considering, for example, the effect that the variability in the thickness of adipose and muscular tissues could have on the communication performance, and the possible effect that the variability in the transmitted signal power could have on the data packet reception. Fat tissue displays superior performance in comparison to muscle tissue in the context of a low loss communication channel. For example, at 2.45 GHz, the path losses of ~0.7 dB/cm and ~1.9 dB/cm were observed for phantom and ex-vivo measurements, respectively. At a higher frequency of 5.8 GHz, the ex-vivo path loss was around 1.4 dB/cm. It was concluded from the results that the adipose tissue could function as a reliable medium supporting intra-body communication even under low power transmitted signals. Moreover, although the presence of thick blood vessels could degrade the signal strength, the results show that communication is possible even under the presence of perturbant tissues. Overall, the results of this thesis would provide a foundation in this area and assist researchers in developing innovative and solutions for intra-body communication.
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| 16. |
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| 17. |
- Brout, Dillon, et al.
(författare)
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The Pantheon+ analysis : cosmological constraints
- 2022
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Ingår i: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 938:2
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Tidskriftsartikel (refereegranskat)abstract
- We present constraints on cosmological parameters from the Pantheon+ analysis of 1701 light curves of 1550 distinct Type Ia supernovae (SNe Ia) ranging in redshift from z = 0.001 to 2.26. This work features an increased sample size from the addition of multiple cross-calibrated photometric systems of SNe covering an increased redshift span, and improved treatments of systematic uncertainties in comparison to the original Pantheon analysis, which together result in a factor of 2 improvement in cosmological constraining power. For a flat ΛCDM model, we find ΩM = 0.334 ± 0.018 from SNe Ia alone. For a flat w0CDM model, we measure w0 = −0.90 ± 0.14 from SNe Ia alone, H0 = 73.5 ± 1.1 km s−1 Mpc−1 when including the Cepheid host distances and covariance (SH0ES), and w0 = -0.978-+0.0310.024 when combining the SN likelihood with Planck constraints from the cosmic microwave background (CMB) and baryon acoustic oscillations (BAO); both w0 values are consistent with a cosmological constant. We also present the most precise measurements to date on the evolution of dark energy in a flat w0waCDM universe, and measure wa = -0.1-+2.00.9 from Pantheon+ SNe Ia alone, H0 = 73.3 ± 1.1 km s−1 Mpc−1 when including SH0ES Cepheid distances, and wa = -0.65-+0.320.28 when combining Pantheon+ SNe Ia with CMB and BAO data. Finally, we find that systematic uncertainties in the use of SNe Ia along the distance ladder comprise less than one-third of the total uncertainty in the measurement of H0 and cannot explain the present “Hubble tension” between local measurements and early universe predictions from the cosmological model.
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| 18. |
- Brout, Dillon, et al.
(författare)
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The Pantheon+ analysis : supercal-fragilistic cross calibration, retrained SALT2 light-curve model, and calibration systematic uncertainty
- 2022
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Ingår i: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 938:2
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Tidskriftsartikel (refereegranskat)abstract
- We present a recalibration of the photometric systems in the Pantheon+ sample of Type Ia supernovae (SNe Ia) including those in the SH0ES distance-ladder measurement of H0. We utilize the large and uniform sky coverage of the public Pan-STARRS stellar photometry catalog to cross calibrate against tertiary standards released by individual SN Ia surveys. The most significant updates over the “SuperCal” cross calibration used for the previous Pantheon and SH0ES analyses are: (1) expansion of the number of photometric systems (now 25) and filters (now 105), (2) solving for all filter offsets in all systems simultaneously to produce a calibration uncertainty covariance matrix for cosmological-model constraints, and (3) accounting for the change in the fundamental flux calibration of the Hubble Space Telescope CALSPEC standards from previous versions on the order of 1.5% over a Δλ of 4000 Å. We retrain the SALT2 model and find that our new model coupled with the new calibration of the light curves themselves causes a net distance modulus change (dμ/dz) of 0.04 mag over the redshift range 0 < z < 1. We introduce a new formalism to determine the systematic impact on cosmological inference by propagating the covariance in the fitted calibration offsets through retraining simultaneously with light-curve fitting and find a total calibration uncertainty impact of σw = 0.013; roughly half the size of the sample statistical uncertainty. Similarly, we find the systematic SN calibration contribution to the SH0ES H0 uncertainty is less than 0.2 km s−1 Mpc−1, suggesting that SN Ia calibration cannot resolve the current level of the “Hubble Tension.”
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| 19. |
- Dahalan, Farrah Aini, et al.
(författare)
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A proposed aerobic granules size development scheme for aerobic granulation process.
- 2015
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Ingår i: Bioresource Technology. - : Elsevier BV. - 1873-2976 .- 0960-8524. ; 181, s. 291-296
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Tidskriftsartikel (refereegranskat)abstract
- Aerobic granulation is increasingly used in wastewater treatment due to its unique physical properties and microbial functionalities. Granule size defines the physical properties of granules based on biomass accumulation. This study aims to determine the profile of size development under two physicochemical conditions. Two identical bioreactors namely Rnp and Rp were operated under non-phototrophic and phototrophic conditions, respectively. An illustrative scheme was developed to comprehend the mechanism of size development that delineates the granular size throughout the granulation. Observations on granules' size variation have shown that activated sludge revolutionised into the form of aerobic granules through the increase of biomass concentration in bioreactors which also determined the changes of granule size. Both reactors demonstrated that size transformed in a similar trend when tested with and without illumination. Thus, different types of aerobic granules may increase in size in the same way as recommended in the aerobic granule size development scheme.
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| 20. |
- Haq, Bishrul, et al.
(författare)
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A Semi-Supervised Approach for Aspect Category Detection and Aspect Term Extraction from Opinionated Text
- 2023
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Ingår i: Computers, Materials and Continua. - : Tech Science Press. - 1546-2218 .- 1546-2226. ; 77:1, s. 115-137
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Tidskriftsartikel (refereegranskat)abstract
- The Internet has become one of the significant sources for sharing information and expressing users' opinions about products and their interests with the associated aspects. It is essential to learn about product reviews; however, to react to such reviews, extracting aspects of the entity to which these reviews belong is equally important. Aspect-based Sentiment Analysis (ABSA) refers to aspects extracted from an opinionated text. The literature proposes different approaches for ABSA; however, most research is focused on supervised approaches, which require labeled datasets with manual sentiment polarity labeling and aspect tagging. This study proposes a semi-supervised approach with minimal human supervision to extract aspect terms by detecting the aspect categories. Hence, the study deals with two main sub-tasks in ABSA, named Aspect Category Detection (ACD) and Aspect Term Extraction (ATE). In the first sub-task, aspects categories are extracted using topic modeling and filtered by an oracle further, and it is fed to zero-shot learning as the prompts and the augmented text. The predicted categories are the input to find similar phrases curated with extracting meaningful phrases (e.g., Nouns, Proper Nouns, NER (Named Entity Recognition) entities) to detect the aspect terms. The study sets a baseline accuracy for two main sub-tasks in ABSA on the Multi-Aspect Multi-Sentiment (MAMS) dataset along with SemEval-2014 Task 4 sub-task 1 to show that the proposed approach helps detect aspect terms via aspect categories.
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| 21. |
- Hashem, Ali, et al.
(författare)
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Cementless, modular, distally fixed stem in hip revision arthroplasty : a single-center study of 132 consecutive hips
- 2018
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Ingår i: European Journal of Orthopaedic Surgery & Traumatology. - New York : Springer. - 1633-8065 .- 1432-1068. ; 28:1, s. 45-50
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The use of cementless, modular, distally fixed stem in hip revision arthroplasty has increased during the last decades. We aimed to analyze the early and late postoperative complications, re-operation rate, and survival rate of the MP stem operated at our county hospital with relatively limited caseload.Methods: In this retrospective study, we included 132 hips operated with MP stem between January 2007–2014. An independent observer reviewed patients’ medical records in July 2015 (18–102 months postoperatively, median 52.5) to collect the following data: age, sex, American Society of Anesthesiologists (ASA) class, body mass index, indication of revision, type of operation, early and late complications, re-operation rate, and mortality during study period.Results: The commonest indication for MP stem operation was aseptic loosening (72%). We found early and late postoperative complications in 29% of cases. The most common complication was prosthetic dislocation (8%), followed by intra-operative peri-prosthetic fracture (5%). The commonest indication for MP re-operation was soft tissue revision for infection (7%) followed by closed reduction for prosthetic dislocation (6%). We found no correlation between the age, sex, ASA class, and type of operation and the re-operation risk. Only one prosthesis was extracted giving a survival rate for 99% for the study period.Conclusion: This study showed good results of the MP prosthesis with reasonable complication and re-operation rates and negligible extraction rate, indicating the good performance of this implant even when used in the setting of a county hospital with limited caseload.
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| 22. |
- Khan, Kifayatullah, et al.
(författare)
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Population exposure to emerging perfluoroalkyl acids (PFAAs) via drinking water resources : Application of multivariate statistics and risk assessment models
- 2024
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Ingår i: Marine Pollution Bulletin. - 0025-326X .- 1879-3363. ; 203
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Tidskriftsartikel (refereegranskat)abstract
- This study assessed the occurrence, origins, and potential risks of emerging perfluoroalkyl acids (PFAAs) for the first time in drinking water resources of Khyber Pakhtunkhwa, Pakistan. In total, 13 perfluoroalkyl carboxylic acids (PFCAs) with carbon (C) chains C4-C18 and 4 perfluoroalkyl sulfonates (PFSAs) with C chains C4-C10 were tested in both surface and ground drinking water samples using a high-performance liquid chromatography system (HPLC) equipped with an Agilent 6460 Triple Quadrupole liquid chromatography–mass spectrometry (LC–MS) system. The concentrations of ∑PFCAs, ∑PFSAs, and ∑PFAAs in drinking water ranged from 1.46 to 72.85, 0.30–8.03, and 1.76–80.88 ng/L, respectively. Perfluorobutanoic acid (PFBA), perfluorohexanoic acid (PFHxA), and perfluoropentanoic acid (PFPeA) were the dominant analytes in surface water followed by ground water, while the concentration of perfluorobutane sulfonate (PFBS), perfluorooctanoic acid (PFOA), perfluoroheptanoic acid (PFHpA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), and perfluorododecanoic acid (PFDoDA) were greater than long-chain PFOA and PFOS. The correlation statistics, which showed a strong correlation (p < 0.05) between the PFAA analytes, potentially indicated the fate of PFAAs in the area's drinking water sources, whereas the hierarchical cluster analysis (HCA) and principal component analysis (PCA) statistics identified industrial, domestic, agricultural, and commercial applications as potential point and non-point sources of PFAA contamination in the area. From risk perspectives, the overall PFAA toxicity in water resources was within the ecological health risk thresholds, where for the human population the hazard quotient (HQ) values of individual PFAAs were < 1, indicating no risk from the drinking water sources; however, the hazard index (HI) from the ∑PFAAs should not be underestimated, as it may significantly result in potential chronic toxicity to exposed adults, followed by children.
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| 25. |
- Kocarnik, J. M., et al.
(författare)
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Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Jama Oncology. - : American Medical Association (AMA). - 2374-2437 .- 2374-2445. ; 8:3, s. 420-488
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3%(95% UI, 20.3%-32.3%) increase in new cases, a 20.9%(95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4%(1.1%-1.8%) in the low SDI quintile to 5.7%(4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and YDALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.
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| 26. |
- Naqvi, Salman Raza, et al.
(författare)
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Pyrolysis of high-ash sewage sludge : Thermo-kinetic study using TGA and artificial neural networks
- 2018
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Ingår i: Fuel. - Oxon, UK : Elsevier Ltd. - 0016-2361 .- 1873-7153. ; 233, s. 529-538
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Tidskriftsartikel (refereegranskat)abstract
- Pyrolysis of high-ash sewage sludge (HASS) is a considered as an effective method and a promising way for energy production from solid waste of wastewater treatment facilities. The main purpose of this work is to build knowledge on pyrolysis mechanisms, kinetics, thermos-gravimetric analysis of high-ash (44.6%) sewage sludge using model-free methods & results validation with artificial neural network (ANN). TG-DTG curves at 5,10 and 20 °C/min showed the pyrolysis zone was divided into three zone. In kinetics, E values of models ranges are; Friedman (10.6–306.2 kJ/mol), FWO (45.6–231.7 kJ/mol), KAS (41.4–232.1 kJ/mol) and Popescu (44.1–241.1 kJ/mol) respectively. ΔH and ΔG values predicted by OFW, KAS and Popescu method are in good agreement and ranged from (41–236 kJ/mol) and 53–304 kJ/mol, respectively. Negative value of ΔS showed the non-spontaneity of the process. An artificial neural network (ANN) model of 2 * 5 * 1 architecture was employed to predict the thermal decomposition of high-ash sewage sludge, showed a good agreement between the experimental values and predicted values (R2 ⩾ 0.999) are much closer to 1. Overall, the study reflected the significance of ANN model that could be used as an effective fit model to the thermogravimetric experimental data. © 2018 Elsevier Ltd
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| 27. |
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| 28. |
- Rafiq, M. A., et al.
(författare)
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Mapping of three novel loci for non-syndromic autosomal recessive mental retardation (NS-ARMR) in consanguineous families from Pakistan
- 2010
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Ingår i: Clinical Genetics. - : Wiley. - 0009-9163 .- 1399-0004. ; 78:5, s. 478-483
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Tidskriftsartikel (refereegranskat)abstract
- To date, of 13 loci with linkage to non-syndromic autosomal recessive mental retardation (NS-ARMR), only six genes have been established with associated mutations. Here we present our study on NS-ARMR among the Pakistani population, where people are traditionally bound to marry within the family or the wider clan. In an exceptional, far-reaching genetic survey we have collected more than 50 consanguineous families exhibiting clinical symptoms/phenotypes of NS-ARMR. In the first step, nine families (MR2-9 and MR11) with multiple affected individuals were selected for molecular genetic studies. Two families (MR3, MR4) showed linkage to already know NS-ARMR loci. Fifteen affected and 10 unaffected individuals from six (MR2, MR6, MR7, MR8, MR9 and MR11) families were genotyped by using Affymetrix 5.0 or 6.0 single-nucleotide polymorphism (SNP) microarrays. SNP microarray data was visually inspected by dChip and genome-wide homozygosity analysis was performed by HomozygosityMapper. Additional mapping was performed (to exclude false-positive regions of homozygosity called by HomozygosityMapper and dChip) on all available affected and unaffected members in seven NS-ARMR families, using microsatellite markers. In this manner we were able to map three novel loci in seven different families originating from different areas of Pakistan. Two families (MR2, MR5) showed linkage on chromosome 2p25.3-p25.2. Three families (MR7, MR8, and MR9) that have been collected from the same village and belong to the same clan were mapped on chromosome 9q34.3. MR11 maps to a locus on 9p23-p13.3. Analysis of MR6 showed two positive loci, on chromosome 1q23.2-q23.3 and 8q24.21-q24.23. Genotyping in additional family members has so far narrowed, but not excluded the 1q locus. In summary, through this study we have identified three new loci for NS-ARMR, namely MRT14, 15 and 16.
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| 29. |
- Scolnic, Dan, et al.
(författare)
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The Pantheon+ analysis : the full data set and light-curve release
- 2022
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Ingår i: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 938:2
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Tidskriftsartikel (refereegranskat)abstract
- Here we present 1701 light curves of 1550 unique, spectroscopically confirmed Type Ia supernovae (SNe Ia) that will be used to infer cosmological parameters as part of the Pantheon+ SN analysis and the Supernovae and H0 for the Equation of State of dark energy distance-ladder analysis. This effort is one part of a series of works that perform an extensive review of redshifts, peculiar velocities, photometric calibration, and intrinsic-scatter models of SNe Ia. The total number of light curves, which are compiled across 18 different surveys, is a significant increase from the first Pantheon analysis (1048 SNe), particularly at low redshift (z). Furthermore, unlike in the Pantheon analysis, we include light curves for SNe with z < 0.01 such that SN systematic covariance can be included in a joint measurement of the Hubble constant (H0) and the dark energy equation-of-state parameter (w). We use the large sample to compare properties of 151 SNe Ia observed by multiple surveys and 12 pairs/triplets of “SN siblings”—SNe found in the same host galaxy. Distance measurements, application of bias corrections, and inference of cosmological parameters are discussed in the companion paper by Brout et al., and the determination of H0 is discussed by Riess et al. These analyses will measure w with ∼3% precision and H0 with ∼1 km s−1 Mpc−1 precision.
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| 30. |
- Waqar, Noor, et al.
(författare)
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Joint power and beamforming optimization of UAV-Assisted NOMA networks for B5G-enabled smart cities
- 2021
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Ingår i: 6G-ABS 2021 - Proceedings of the 1st ACM Workshop on Artificial Intelligence and Blockchain Technologies for Smart Cities with 6G, Part of ACM MobiCom 2021. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450387019 ; , s. 25-30
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Konferensbidrag (refereegranskat)abstract
- In this paper, we consider a unmanned aerial vehicle (UAV)-enabled multiple-input single-output (MISO) non-orthogonal multiple access (NOMA) system for a smart city environment, where a multi-Antenna UAV acts as an amplify-And-forward (AF) relay to extend the coverage to several disconnected users aided by NOMA. We present an optimization problem that jointly determines the location of the UAV, optimal beamforming at the UAV and power allocation at the base station (BS), in order to maximize the system sum-rate. Due to the severe non-convexity of the problem, we decouple the problem into three sub-problems and solve them sequentially. First, the optimal location of the UAV is determined by minimizing the total path loss. Next, the UAV beamforming is solved by transforming the problem into second-order cone programming (SOCP) and finally the power allocation at the BS is determined using linear-fractional programming (LFP). The simulation results demonstrate that the proposed scheme performs better than the baseline schemes and orthogonal multiple access (OMA) scheme.
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| 31. |
- Yameen, Muhammad Zubair, et al.
(författare)
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Biodiesel production from marine macroalgae Ulva lactuca lipids using novel Cu-BTC@AC catalyst : Parametric analysis and optimization
- 2024
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Ingår i: Energy Conversion and Management. - : Elsevier. - 2590-1745. ; 23
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Tidskriftsartikel (refereegranskat)abstract
- The pursuit of renewable fuels for the transportation sector, particularly for combustion engines like diesel, is crucial in reducing greenhouse gas emissions. This study introduces an innovative strategy for biodiesel production utilizing marine macroalgae Ulva lactuca as the primary feedstock, emphasizing sustainability and resource efficiency. Lipids were extracted from the macroalgae via a Soxhlet process and characterized using GC–MS and FTIR to ascertain fatty acid composition and functional groups. The Cu–BTC@AC catalyst, synthesized from the lipid-extracted algae residue via pyrolysis and hydrothermal treatment, underwent characterization using SEM–EDS, XRD, and FTIR techniques. Subsequently, the Cu–BTC@AC catalyst was employed in the transesterification process to efficiently convert the extracted algal lipids into biodiesel, achieving a high yield of 92.56 % under RSM-optimized conditions: 65 °C temperature, 3.96 wt% catalyst amount, 15:1 methanol-to-lipid ratio, and 140 min reaction time. Kinetic and thermodynamic parameters for biodiesel production were calculated as follows: Ea = 33.20 kJ mol−1, ΔH# = 30.39 kJ mol−1, ΔS# = –165.86 J mol−1 K−1, and ΔG# = 86.48 kJ mol−1. GC–MS analysis identified a significant FAME content in the biodiesel, comprising 98.12 % of its composition. Notably, the Cu–BTC@AC catalyst exhibited excellent reusability, maintaining 80.21 % biodiesel yield after the third cycle. Moreover, physicochemical analysis of the biodiesel confirmed its compliance with ASTM D6751 specifications, underscoring its potential as a viable alternative fuel for the transportation sector.
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