| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Allander, E
(författare)
-
'Syndromes' and reasons not to do a project
- 1997
-
Ingår i: Journal of public health medicine. - : Oxford University Press (OUP). - 0957-4832 .- 1741-3842 .- 1741-3850. ; 19:3, s. 361-361
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 7. |
- Allander, E, et al.
(författare)
-
Why is prevention so difficult and slow?
- 1997
-
Ingår i: Scandinavian journal of social medicine. - : SAGE Publications. - 0300-8037. ; 25:3, s. 145-148
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- abundance of perceived “possibilities” for prevention rasts sharply with the difficulties that face preventive grammes. We argue that this situation has emerged from incomplete understanding of the process of prevention, Iving a mixture of biological factors, human decisioning and time perspectives. Based on examples, anlysis of the factors in the prevention process is presented.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
- Bogdanovic, G, et al.
(författare)
-
Virome characterisation from Guthrie cards in children who later developed acute lymphoblastic leukaemia.
- 2016
-
Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 115:8, s. 1008-1014
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Some childhood acute lymphoblastic leukaemias (ALL) can be traced back to a prenatal origin, where a virus infection could be involved in the first pre-leukaemic clone development. The DNA virome of 95 children who later developed ALL was characterised from neonatal blood spots (NBS) using unbiased next-generation sequencing (NGS) and compared with the virome of 95 non-ALL controls.METHODS: DNA was individually extracted from the ALL-patients and controls, pooled, randomly amplified and sequenced using the Illumina MiSeq Sequencing System.RESULTS: Virus-like sequences identified in both groups mapped to human endogenous retroviruses and propionibacterium phage, considered a part of the normal microbial flora. Potential pathogens human herpesvirus type 6 (HHV-6) and parvovirus B19 were also identified, but only few samples in both ALL and controls tested positive by PCR follow-up.CONCLUSIONS: Unbiased NGS was employed to search for DNA from potential infectious agents in neonatal samples of children who later developed ALL. Although several viral candidates were identified in the NBS samples, further investigation by PCR suggested that these viruses did not have a major role in ALL development.
|
|
| 12. |
- Dahdouh, Elias, et al.
(författare)
-
Computational Modeling and Design of New Inhibitors of Carbapenemases : A Discussion from the EPIC Alliance Network
- 2022
-
Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 23:17
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The EPIC consortium brings together experts from a wide range of fields that include clinical, molecular and basic microbiology, infectious diseases, computational biology and chemistry, drug discovery and design, bioinformatics, biochemistry, biophysics, pharmacology, toxicology, veterinary sciences, environmental sciences, and epidemiology. The main question to be answered by the EPIC alliance is the following: "What is the best approach for data mining on carbapenemase inhibitors and how to translate this data into experiments?" From this forum, we propose that the scientific community think up new strategies to be followed for the discovery of new carbapenemase inhibitors, so that this process is efficient and capable of providing results in the shortest possible time and within acceptable time and economic costs.
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Lindefeldt, M, et al.
(författare)
-
The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy
- 2019
-
Ingår i: NPJ biofilms and microbiomes. - : Springer Science and Business Media LLC. - 2055-5008. ; 5:1, s. 5-
-
Tidskriftsartikel (refereegranskat)abstract
- The gut microbiota has been linked to various neurological disorders via the gut–brain axis. Diet influences the composition of the gut microbiota. The ketogenic diet (KD) is a high-fat, adequate-protein, low-carbohydrate diet established for treatment of therapy-resistant epilepsy in children. Its efficacy in reducing seizures has been confirmed, but the mechanisms remain elusive. The diet has also shown positive effects in a wide range of other diseases, including Alzheimer’s, depression, autism, cancer, and type 2 diabetes. We collected fecal samples from 12 children with therapy-resistant epilepsy before starting KD and after 3 months on the diet. Parents did not start KD and served as diet controls. Applying shotgun metagenomic DNA sequencing, both taxonomic and functional profiles were established. Here we report that alpha diversity is not changed significantly during the diet, but differences in both taxonomic and functional composition are detected. Relative abundance of bifidobacteria as well as E. rectale and Dialister is significantly diminished during the intervention. An increase in relative abundance of E. coli is observed on KD. Functional analysis revealed changes in 29 SEED subsystems including the reduction of seven pathways involved in carbohydrate metabolism. Decomposition of these shifts indicates that bifidobacteria and Escherichia are important contributors to the observed functional shifts. As relative abundance of health-promoting, fiber-consuming bacteria becomes less abundant during KD, we raise concern about the effects of the diet on the gut microbiota and overall health. Further studies need to investigate whether these changes are necessary for the therapeutic effect of KD.
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
|
|
