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- Almgren, Oscar
(författare)
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En uppländsk bronsåldershydda
- 1912
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Ingår i: Fornvännen. - 0015-7813 .- 1404-9430. ; 7, s. 132-151
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Almgren, Oscar
(författare)
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Förhistoriska flintgrufvor i Skåne
- 1906
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Ingår i: Fornvännen. - 0015-7813 .- 1404-9430. ; 1, s. 51-52
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Almgren, Oscar
(författare)
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Nordiska stenåldersskulpturer
- 1907
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Ingår i: Fornvännen. - 0015-7813 .- 1404-9430. ; 2, s. 113-125
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 8. |
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| 9. |
- Almgren, Oscar
(författare)
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Om fynden af romerska silfvermynt i Norden
- 1901
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Ingår i: Svenska fornminnesföreningens tidskrift. - 0283-2496. ; 1:2, s. 187-196
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 16. |
- Almgren, Oscar
(författare)
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Uppländska stenåldersboplatser
- 1906
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Ingår i: Fornvännen. - 0015-7813 .- 1404-9430. ; 1, s. 1-19
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 17. |
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| 18. |
- Almgren, Oscar
(författare)
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Vikingatidsgrafvar i Sagån vid Sala
- 1907
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Ingår i: Fornvännen. - 0015-7813 .- 1404-9430. ; 2, s. 1-19
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 19. |
- Almgren, Susanne, 1967-
(författare)
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Users and producers : Online News as Mediated Participation
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The purpose of this thesis is to illuminate principles that guide mediated participation, taking place through the interplay between users and news producers. Therefore, the study focuses both how spaces for participation are structured (by news producers) and those that exert participatory practices (news users). The research design thus has an approach that ties together analytical strands that previously have been studied separately. The research questions concern how the conditions comprising mediated participation – in terms of opportunities for users’ participatory practices – differ between (1a) various types of online news sites, and (1b) various types of news, as well as how users exercise participatory practices (2a) on various types of news sites, and (2b) in connection to various types of news. The last research question (3) concerns how users express the connection to news producers, through participatory practices within participatory spaces. The thesis includes four papers, that together answer the research questions by applying content and text analyses to various types of news sites (big city national, local rural area, morning broadsheets and evening tabloids) and its content: news articles and features for user participation, such as comments and sharing news through social media (i.e., Facebook and Twitter).The results show that users and news producers take diverging approaches to user participation adjacent to online news. This is illustrated by the fact that the categories of news that users are most often permitted to interact with, coincide precisely with the news that users tend to decline to interact with, while the news categories that users tend to interact with (when given the chance) occur comparatively sparse. The results also show that news producers are much more prone to permit users to share news through social media, than to permit them to comment news on the news site. Almost all news are made to permit users to share news through Facebook and Twitter, whereas commenting news is substantially more restricted, and even more so among big city national news sites than among local rural area news sites. When it concerns user practices, users share news on Facebook 20 times more often than they share news through Twitter or comment news on news sites. Tweeting news almost only occurs in news sites affiliated with big city national newspapers, and most prominently so when it concerns evening tabloids. This means (when controlling for differences in circulation) that commenting as a user practice tend to have a more local character than tweeting news, with its more national focus.The connection between users and news producers is shaped by the approach these groups of actors take to each other, under different circumstances. Sharing news through Facebook and commenting on news sites, are not interchangeable practices. Nor is tweeting news from a news site affiliated with national tabloid compared to from a local morning newspaper. And although it is well known from extant research that producers hold hesitant views concerning users’ influence over content, users also express distrust when it concerns how professional media practices allow various actors salience in the media. These ideas primarily concern “elites” versus “commoners”, differences between public service and commercial media, regulations and media, including roles, genres, and formats. These ideas also concern whether representational principles should guide media representation or if certain views should be excluded, whether journalists’ political views affect media performance, and how crime news should be presented in terms of what events are published and representations of victims and perpetrators. Overall, the thesis illustrates that there are connections between various forms of electronic communication (i.e., commenting and sharing news through Facebook and Twitter), and the specific contextual and social settings that news sites are embedded within, with its specific situated audience, shaping the connections between users and news producers.
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| 20. |
- Evangelou, Evangelos, et al.
(författare)
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
- 2018
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425
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Tidskriftsartikel (refereegranskat)abstract
- High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
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| 21. |
- Mahajan, Anubha, et al.
(författare)
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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
- 2018
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:4, s. 559-571
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Tidskriftsartikel (refereegranskat)abstract
- We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10−7); of these, 16 map outside known risk-associated loci. We make two important observations. First, only five of these signals are driven by low-frequency variants: even for these, effect sizes are modest (odds ratio ≤1.29). Second, when we used large-scale genome-wide association data to fine-map the associated variants in their regional context, accounting for the global enrichment of complex trait associations in coding sequence, compelling evidence for coding variant causality was obtained for only 16 signals. At 13 others, the associated coding variants clearly represent ‘false leads’ with potential to generate erroneous mechanistic inference. Coding variant associations offer a direct route to biological insight for complex diseases and identification of validated therapeutic targets; however, appropriate mechanistic inference requires careful specification of their causal contribution to disease predisposition.
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| 22. |
- Roselli, Carolina, et al.
(författare)
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Multi-ethnic genome-wide association study for atrial fibrillation
- 2018
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233
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Tidskriftsartikel (refereegranskat)abstract
- Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
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| 23. |
- Sabater-Lleal, Maria, et al.
(författare)
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Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease.
- 2014
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:8
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Tidskriftsartikel (refereegranskat)abstract
- Chronic obstructive pulmonary disease (COPD) independently associates with an increased risk of coronary artery disease (CAD), but it has not been fully investigated whether this co-morbidity involves shared pathophysiological mechanisms. To identify potential common pathways across the two diseases, we tested all recently published single nucleotide polymorphisms (SNPs) associated with human lung function (spirometry) for association with carotid intima-media thickness (cIMT) in 3,378 subjects with multiple CAD risk factors, and for association with CAD in a case-control study of 5,775 CAD cases and 7,265 controls. SNPs rs2865531, located in the CFDP1 gene, and rs9978142, located in the KCNE2 gene, were significantly associated with CAD. In addition, SNP rs9978142 and SNP rs3995090 located in the HTR4 gene, were associated with average and maximal cIMT measures. Genetic risk scores combining the most robustly spirometry-associated SNPs from the literature were modestly associated with CAD, (odds ratio (OR) (95% confidence interval (CI95) = 1.06 (1.03, 1.09); P-value = 1.5×10-4, per allele). In conclusion, our study suggests that some genetic loci implicated in determining human lung function also influence cIMT and susceptibility to CAD. The present results should help elucidate the molecular underpinnings of the co-morbidity observed across COPD and CAD.
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| 24. |
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| 25. |
- Wuttke, Matthias, et al.
(författare)
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A catalog of genetic loci associated with kidney function from analyses of a million individuals
- 2019
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Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
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Tidskriftsartikel (refereegranskat)abstract
- Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
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