SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Almqvist Per) "

Sökning: WFRF:(Almqvist Per)

  • Resultat 1-50 av 74
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Huttunen, Henri J., et al. (författare)
  • Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double-Blind, Multicenter Phase 1 Trial
  • 2023
  • Ingår i: Movement Disorders. - : John Wiley & Sons. - 0885-3185 .- 1531-8257. ; 38:7, s. 1209-1222
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotrophic factor that protects dopamine neurons and improves motor function in animal models of Parkinson's disease (PD). Objective: The primary objectives of this study were to assess the safety and tolerability of both CDNF and the drug delivery system (DDS) in patients with PD of moderate severity. Methods: We assessed the safety and tolerability of monthly intraputamenal CDNF infusions in patients with PD using an investigational DDS, a bone-anchored transcutaneous port connected to four catheters. This phase 1 trial was divided into a placebo-controlled, double-blind, 6-month main study followed by an active-treatment 6-month extension. Eligible patients, aged 35 to 75 years, had moderate idiopathic PD for 5 to 15 years and Hoehn and Yahr score ≤ 3 (off state). Seventeen patients were randomized to placebo (n = 6), 0.4 mg CDNF (n = 6), or 1.2 mg CDNF (n = 5). The primary endpoints were safety and tolerability of CDNF and DDS and catheter implantation accuracy. Secondary endpoints were measures of PD symptoms, including Unified Parkinson's Disease Rating Scale, and DDS patency and port stability. Exploratory endpoints included motor symptom assessment (PKG, Global Kinetics Pty Ltd, Melbourne, Australia) and positron emission tomography using dopamine transporter radioligand [18F]FE-PE2I. Results: Drug-related adverse events were mild to moderate with no difference between placebo and treatment groups. No severe adverse events were associated with the drug, and device delivery accuracy met specification. The severe adverse events recorded were associated with the infusion procedure and did not reoccur after procedural modification. There were no significant changes between placebo and CDNF treatment groups in secondary endpoints between baseline and the end of the main and extension studies. Conclusions: Intraputamenally administered CDNF was safe and well tolerated, and possible signs of biological response to the drug were observed in individual patients. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
  •  
2.
  • Paul-Visse, Gesine, et al. (författare)
  • Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients
  • 2015
  • Ingår i: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 125:3, s. 1339-1346
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND. Recombinant human PDGF-BB (rhPDGF-BB) reduces Parkinsonian symptoms and increases dopamine transporter (DAT) binding in several animal models of Parkinson's disease (PD). Effects of rhPDGF-BB are the result of proliferation of ventricular wall progenitor cells and reversed by blocking mitosis. Based on these restorative effects, we assessed the safety and tolerability of intracerebroventricular (i.c.v.) rhPDGF-BB administration in individuals with PD. METHODS. We conducted a double-blind, randomized, placebo-controlled phase I/IIa study at two clinical centers in Sweden. Twelve patients with moderate PD received rhPDGF-BB via an implanted drug infusion pump and an investigational i.c.v. catheter. Patients were assigned to a dose cohort (0.2, 1.5, or 5 mu g rhPDGF-BB per day) and then randomized to active treatment or placebo (3:1) for a 12-day treatment period. The primary objective was to assess safety and tolerability of i.c.v.-delivered rhPDGF-BB. Secondary outcome assessments included several clinical rating scales and changes in DAT binding. The follow-up period was 85 days. RESULTS. All patients completed the study. There were no unresolved adverse events. Serious adverse events occurred in three patients; however, these were unrelated to rhPDGF-BB administration. Secondary outcome parameters did not show dose-dependent changes in clinical rating scales, but there was a positive effect on DAT binding in the right putamen. CONCLUSION. At all doses tested, i.c.v. administration of rhPDGF-BB was well tolerated. Results support further clinical development of rhPDGF-BB for patients with PD.
  •  
3.
  • Almqvist, Helena, et al. (författare)
  • CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
  • 2016
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Target engagement is a critical factor for therapeutic efficacy. Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. We report here the first compound library screen based on biophysical measurements of intracellular target binding, exemplified by human thymidylate synthase (TS). The screen selected accurately for all the tested known drugs acting on TS. We also identified TS inhibitors with novel chemistry and marketed drugs that were not previously known to target TS, including the DNA methyltransferase inhibitor decitabine. By following the cellular uptake and enzymatic conversion of known drugs we correlated the appearance of active metabolites over time with intracellular target engagement. These data distinguished a much slower activation of 5-fluorouracil when compared with nucleoside-based drugs. The approach establishes efficient means to associate drug uptake and activation with target binding during drug discovery.
  •  
4.
  •  
5.
  • Andree, Maria, et al. (författare)
  • Knowledge Products from Close-To-Practice Research
  • 2024
  • Ingår i: Round table presentation at the NERA-conference, 6-8 March, Malmö University.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • ‘Close-to-practice research’ has received increased attention across the Nordic countries. Following the British Education Research Association (BERA), the notion of ‘close-to-practice research’ is used to refer to educational research that is based on problems in practice, often involves researchers working in partnership with practitioners in schools and addresses issues of relevance to practitioners. This roundtable focuses on how close-to-practice research can contribute to the knowledge base of the teaching profession by bringing together perspectives from didactics, school improvement and educational policy. More specifically, the interest is directed toward what characterizes the knowledge produced through practice-based research that may have significance for teachers' professional knowledge base and practice. The roundtable conversation builds on a previous analysis of what kinds of knowledge products are generated in didactic close-to-practice research where teachers and researchers work together within the research environment Stockholm Teaching & Learning Studies. As a result of this analysis a typology of knowledge products was proposed including: (i) descriptions of knowing, (ii) teaching design, (iii) didactic examples and (iv) methodological tools. It has been proposed that additional knowledge products may be developed, such as artifacts to be used in teaching (e.g. lesson plans, visual representations). The roundtable will include the following points of discussion: 1) a brief presentation of the typology, 2) challenging and developing the typology of knowledge products proposed by previous research by investigating different cases of close-to-practice research from traditions of action research and practice-developing research within subject-didactics, and 3) discussing how the notion of knowledge products may contribute to advancing the conversation on cumulativity in the field of educational research in general, and in relation to syntheses of close-to-practice research in particular. The participants will be engaged in conversations on the desirability and feasibility of striving towards cumulativity.
  •  
6.
  •  
7.
  •  
8.
  • Dalemo, Sofia, et al. (författare)
  • Long-term follow-up of patients with elevated serum calcium concentration in Swedish primary care
  • 2013
  • Ingår i: Scandinavian Journal of Primary Health Care. - : Informa UK Limited. - 0281-3432 .- 1502-7724. ; 31:4, s. 248-254
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective. To follow up patients with elevated calcium concentrations after 10 years. Design. Longitudinal, using medical records, questionnaires, and clinical investigation. Setting. Primary care in Tibro, Sweden, 2008–2010. Subjects. 127 patents with elevated calcium concentrations and 254 patients with normal calcium concentrations from the local community, attending the health care centre. Main outcome measures. Diagnoses and mortality in patients with elevated calcium concentrations in 1995–2000, compared with patients with normal calcium concentrations and the background population. Results. The proportion of patients for whom no underlying cause was detected decreased from 55% at baseline to 12% at follow-up. Primary hyperparathyroidism was most common in women, 23% at baseline and 36% at follow-up, and the cancer prevalence increased from 5% to 12% in patients with elevated calcium concentration. Mortality tended to be higher in men with elevated calcium concentrations compared with men with normal calcium concentrations, and was significantly higher than in the background population (SMR 2.3, 95% CI 1.3–3.8). Cancer mortality was significantly increased in men (p = 0.039). Low calcium concentrations were also associated with higher mortality (p = 0.004), compared with patients with normal calcium concentrations. Conclusion. This study underscores the importance of investigating patients with increased calcium concentrations suggesting that most of these patients – 88% in our study – will turn out to have an underlying disease associated with hypercalcaemia during a 10-year follow-up period. Elevated calcium concentrations had a different disease pattern in men and women, with men showing increased cancer mortality in this study. Read More: http://informahealthcare.com/doi/abs/10.3109/02813432.2013.861152
  •  
9.
  • DHaens, Geert, et al. (författare)
  • Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohns Disease Patients: A Prospective Open-label Study
  • 2023
  • Ingår i: Journal of Crohn's & Colitis. - : OXFORD UNIV PRESS. - 1873-9946 .- 1876-4479. ; 17:12, s. 1897-1909
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and Aims Crohns disease [CD] is a debilitating, inflammatory condition affecting the gastrointestinal tract. There is no cure and sustained clinical and endoscopic remission is achieved by fewer than half of patients with current therapies. The immunoregulatory function of the vagus nerve, the inflammatory reflex, has been established in patients with rheumatoid arthritis and biologic-naive CD. The aim of this study was to explore the safety and efficacy of vagus nerve stimulation in patients with treatment-refractory CD, in a 16-week, open-label, multicentre, clinical trial.Methods A vagus nerve stimulator was implanted in 17 biologic drug-refractory patients with moderately to severely active CD. One patient exited the study pre-treatment, and 16 patients were treated with vagus nerve stimulation [4/16 receiving concomitant biologics] during 16 weeks of induction and 24 months of maintenance treatment. Endpoints included clinical improvement, patient-reported outcomes, objective measures of inflammation [endoscopic/molecular], and safety.Results There was a statistically significant and clinically meaningful decrease in CD Activity Index at Week 16 [mean +/- SD: -86.2 +/- 92.8, p = 0.003], a significant decrease in faecal calprotectin [-2923 +/- 4104, p = 0.015], a decrease in mucosal inflammation in 11/15 patients with paired endoscopies [-2.1 +/- 1.7, p = 0.23], and a decrease in serum tumour necrosis factor and interferon-gamma [46-52%]. Two quality-of-life indices improved in 7/11 patients treated without biologics. There was one study-related severe adverse event: a postoperative infection requiring device explantation.Conclusions Neuroimmune modulation via vagus nerve stimulation was generally safe and well tolerated, with a clinically meaningful reduction in clinical disease activity associated with endoscopic improvement, reduced levels of faecal calprotectin and serum cytokines, and improved quality of life. Graphical Abstract
  •  
10.
  • Eriksdotter-Jönhagen, Maria, et al. (författare)
  • Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease.
  • 2012
  • Ingår i: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 33:1, s. 18-28
  • Tidskriftsartikel (refereegranskat)abstract
    • Degeneration of cholinergic neurons in the basal forebrain correlates with cognitive decline in patients with Alzheimer's disease (AD). Targeted delivery of exogenous nerve growth factor (NGF) has emerged as a potential AD therapy due to its regenerative effects on the basal forebrain cholinergic neurons in AD animal models. Here we report the results of a first-in-man study of encapsulated cell (EC) biodelivery of NGF to the basal forebrain of AD patients with the primary objective to explore safety and tolerability.
  •  
11.
  • Ferreira, Daniel, et al. (författare)
  • Brain changes in Alzheimer's disease patients with implanted encapsulated cells releasing nerve growth factor
  • 2015
  • Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 43, s. 1059-1072
  • Tidskriftsartikel (refereegranskat)abstract
    • © 2015-IOS Press and the authors. New therapies with disease-modifying effects are urgently needed for treating Alzheimer's disease (AD). Nerve growth factor (NGF) protein has demonstrated regenerative and neuroprotective effects on basal forebrain cholinergic neurons in animal studies. In addition, AD patients treated with NGF have previously shown improved cognition, EEG activity, nicotinic binding, and glucose metabolism. However, no study to date has analyzed brain atrophy in patients treated with NGF producing cells. In this study we present MRI results of the first clinical trial in patients with AD using encapsulated NGF biodelivery to the basal forebrain. Six AD patients received the treatment during twelve months. Patients were grouped as responders and non-responders according to their twelve-months change in MMSE. Normative values were created from 131 AD patients from ADNI, selecting 36 age-and MMSE-matched patients for interpreting the longitudinal changes in MMSE and brain atrophy. Results at baseline indicated that responders showed better clinical status and less pathological levels of cerebrospinal fluid (CSF) Aβ1-42. However, they showed more brain atrophy, and neuronal degeneration as evidenced by higher CSF levels of T-tau and neurofilaments. At follow-up, responders showed less brain shrinkage and better progression in the clinical variables and CSF biomarkers. Noteworthy, two responders showed less brain shrinkage than the normative ADNI group. These results together with previous evidence supports the idea that encapsulated biodelivery of NGF might have the potential to become a new treatment strategy for AD with both symptomatic and disease-modifying effects.
  •  
12.
  • Good, James A. D., 1985-, et al. (författare)
  • Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity
  • 2016
  • Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 59:5, s. 2094-2108
  • Tidskriftsartikel (refereegranskat)abstract
    • The bacterial pathogen Chlamydia trachomatis is a global health burden currently treated with broad-spectrum antibiotics which disrupt commensal bacteria. We recently identified a compound through phenotypic screening that blocked infectivity of this intracellular pathogen without host cell toxicity (compound 1, KSK 120). Herein, we present the optimization of 1 to a class of thiazolino 2-pyridone amides that are highly efficacious (EC50 <= 100 nM) in attenuating infectivity across multiple serovars of C. trachomatis without host cell toxicity. The lead compound 21a exhibits reduced lipophilicity versus 1 and did not affect the growth or viability of representative commensal flora at 50 mu M. In microscopy studies, a highly active fluorescent analogue 37 localized inside the parasitiphorous inclusion, indicative of a specific targeting of bacterial components. In summary, we present a class of small molecules to enable the development of specific treatments for C. trachomatis.
  •  
13.
  • Granlund, Mats, 1954-, et al. (författare)
  • Tidig upptäckt - tidig insats (TUTI) : slutrapport
  • 2015
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Ur sammanfattningen: Små barns psykiska hälsa har de senaste åren uppmärksammats mer än tidigare. De insatser som görs för att stärka hälsa hos små barn har visat sig ge goda effekter på barns psykiska hälsa senare i livet. Förskolan har lyfts fram både som en miljö i vilken barns psykiska ohälsa tidigt kan upptäckas men också som en miljö som genom tidiga insatser kan främja god psykisk hälsa och ge skydd mot ohälsa. Angående små barn i Sverige saknas en samlad kunskap om väl validerade instrument för att mäta psykisk ohälsa hos små barn, förekomsten av psykisk ohälsa och även om de åtgärder som görs i förskolan för att skydda mot senare negativ utveckling av psykisk hälsa hos barnen. Uppdraget från Socialstyrelsen handlar om att validera ett instrument för att mäta beteendeproblem hos små barn och att kartlägga förekomsten av beteendeproblem hos små barn. Även åtgärder som utförs i förskolan för gruppen kartläggs. Fokus ligger alltså på tidig upptäckt och tidig insats (TUTI) när det gäller små barn som uppvisar beteendeproblem i förskolan.
  •  
14.
  • Greiff, Lennart, et al. (författare)
  • Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis
  • 2012
  • Ingår i: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921. ; 13
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Interactions between Th1 and Th2 immune responses are of importance to the onset and development of allergic disorders. A Toll-like receptor 7 agonist such as AZD8848 may have potential as a treatment for allergic airway disease by skewing the immune system away from a Th2 profile. Objective: To evaluate the efficacy and safety of intranasal AZD8848. Methods: In a placebo-controlled single ascending dose study, AZD8848 (0.3-600 mu g) was given intranasally to 48 healthy subjects and 12 patients with allergic rhinitis (NCT00688779). In a placebo-controlled repeat challenge/treatment study, AZD8848 (30 and 60 mu g) was given once weekly for five weeks to 74 patients with allergic rhinitis out of season: starting 24 hours after the final dose, daily allergen challenges were given for seven days (NCT00770003). Safety, tolerability, pharmacokinetics, and biomarkers were monitored. During the allergen challenge series, nasal symptoms and lavage fluid levels of tryptase and alpha(2)-macroglobulin, reflecting mast cell activity and plasma exudation, were monitored. Results: AZD8848 produced reversible blood lymphocyte reductions and dose-dependent flu-like symptoms: 30100 mu g produced consistent yet tolerable effects. Plasma interleukin-1 receptor antagonist was elevated after administration of AZD8848, reflecting interferon production secondary to TLR7 stimulation. At repeat challenge/treatment, AZD8848 reduced nasal symptoms recorded ten minutes after allergen challenge up to eight days after the final dose. Tryptase and a2-macroglobulin were also reduced by AZD8848. Conclusions: Repeated intranasal stimulation of Toll-like receptor 7 by AZD8848 was safe and produced a sustained reduction in the responsiveness to allergen in allergic rhinitis.
  •  
15.
  • Gumaelius, Lena, et al. (författare)
  • Outreach initiatives operated by universities for increasing interest in science and technology
  • 2016
  • Ingår i: European Journal of Engineering Education. - : Taylor & Francis Group. - 0304-3797 .- 1469-5898. ; , s. 1-34
  • Tidskriftsartikel (refereegranskat)abstract
    • Since the 1990s, the low number of students choosing to study science and technology in higher education has been on the societal agenda and many initiatives have been launched to promote awareness regarding career options. The initiatives particularly focus on increasing enrolment in the engineering programmes. This article describes and compares eight European initiatives that have been established and operated by universities (and in some cases through collaboration with other actors in society). Each initiative is summarised in a short essay that discusses motivation, organisation, pedagogical approach, and activities. The initiatives are characterised by comparing the driving forces behind their creation, how the initiative activities relate to the activities at the university, size based on the number of participants and cost per participant and pedagogical framework. There seem to be two main tracks for building outreach activities, one where outreach activities are based on the university's normal activities, and one where outreach activities are designed specifically for the visiting students.
  •  
16.
  • Gustafsson, Berit, 1966-, et al. (författare)
  • Longitudinal pathways of engagement, social interaction skills,hyperactivity and conduct problems in preschool children
  • 2021
  • Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 62:2, s. 170-184
  • Tidskriftsartikel (refereegranskat)abstract
    • Preschool children’s engagement/social interaction skills can be seen as aspects of positive functioning, and also act as protective aspects of functioning.On the other hand, hyperactivity/conduct problems are risk aspects that negatively affect children’s everyday functioning. Few studies have investigatedsuch orchestrated effects on mental health in young children over time. The aims of the study are rst, to identify homogeneous groups of children havingsimilar pathways in mental health between three time points. Second, to examine how children move between time points in relation to risk and protectivefactors. Alongitudinal study over 3 years, including 197 Swedish preschool children was used. Questionnaire data collected from preschool teachers.Statistical analysis using person-oriented methods with repeated cluster analyses. Children high in engagement/social skills and low in conduct problemscontinue to function well. Children with low engagement/social skills exhibiting both hyperactivity and conduct problems continue to have problems.Children with mixed patterns of protective factors and risk factors showed mixed outcomes. The stability of children’s pathways was quite high if theyexhibited many positive protective factors but also if they exhibited many risk factors. Children exhibiting a mixed pattern of protective and risk factorsmoved between clusters in a less predictable way. That stability in mental health was related to the simultaneous occurrence of either many protectivefactors or many risk factors supports the notion of orchestrated effects. The results indicate that early interventions need to have a dual focus, includingboth interventions aimed at enhancing child engagement and interventions focused on decreasing behavior problem.
  •  
17.
  • Harlin, Eva-Marie (författare)
  • Lärares reflektion och professionella utveckling : Med video som verktyg
  • 2013
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Syftet med denna avhandling är att bidra till förståelsen av hur lärares professionella utveckling kan stödjas. Detta har gjorts genom att undersöka vilka konsekvenserna blir av att lärare ser sig själva på videoinspelningar från sin egen undervisning. Resultaten som presenteras bygger på en longitudinell undersökning. I den första studien deltog lärarstudenter som gick sista terminen på folkhögskollärarprogrammet. De spelade in sin undervisning under den verksamhetsförlagda delen av utbildningen, ”praktiken” på en folkhögskola. Det som eftersöktes var vilka situationer som överraskade lärarstudenterna när de sedan såg sig själva på film. De skrev ner sina reflektioner och resultatet visade att överraskningarna handlade om bristen på lyhördhet i relation till deltagarna. De formulerade också tankar om hur de skulle vilja agera i klassrummet. I den uppföljande studien spelade några av dessa personer, som nu varit verksamma folkhögskollärare i två år efter avslutad utbildning, återigen in en av sina lektioner. Denna gång beskrev lärarna att de på filmen såg att de hade förändrat eller utvecklat sina handlingsvanor till ett mer deltagarorienterat förhållningssätt. De beskrev också att de agerade på ett mer professionellt sätt. Den teori som legat till grund för analysen har sin grund i ett pragmatiskt synsätt på lärande. Från symbolisk interaktionism har begreppen ”I” och ”me” använts, och för att i det här fallet undersöka den professionella aspekten av ”me” har begreppet ”professionalme” prövats.
  •  
18.
  • Hedin, Peter, 1981-, et al. (författare)
  • 3D reflection seismic imaging at the 2.5 km deep COSC-1 scientific borehole, central Scandinavian Caledonides
  • 2016
  • Ingår i: Tectonophysics. - : Elsevier. - 0040-1951 .- 1879-3266. ; 689, s. 40-55
  • Tidskriftsartikel (refereegranskat)abstract
    • The 2.5 km deep scientific COSC-1 borehole (ICDP 5054-1-A) was successfully drilled with nearly complete core recovery during spring and summer of 2014. Downhole and on-core measurements through the targeted Lower Seve Nappe provide a comprehensive data set. An observed gradual increase in strain below 1700 m, with mica schists and intermittent mylonites increasing in frequency and thickness, is here interpreted as the basal thrust zone of the Lower Seve Nappe. This high strain zone was not fully penetrated at the total drilled depth and is thus greater than 800 m in thickness.To allow extrapolation of the results from downhole logging, core analysis and other experiments into the surrounding rock and to link these with the regional tectonic setting and evolution, three post-drilling high-resolution seismic experiments were conducted in and around the borehole. One of these, the first 3D seismic reflection land survey to target the nappe structures of the Scandinavian Caledonides, is presented here. It provides new information on the 3D geometry of structures both within the drilled Lower Seve Nappe and underlying rocks down to at least 9 km.The observed reflectivity correlates well with results from the core analysis and downhole logging, despite challenges in processing. Reflections from the uppermost part of the Lower Seve Nappe have limited lateral extent and varying dips, possibly related to mafic lenses or boudins of variable character within felsic rock. Reflections occurring within the high strain zone, however, are laterally continuous over distances of a kilometer or more and dip 10–15° towards the southeast. Reflections from structures beneath the high strain unit and the COSC-1 borehole can be followed through most of the seismic volume down to at least 9 km and have dips of varying degree, mainly in the east–west thrust direction of the orogen.
  •  
19.
  • Hoglund, L, et al. (författare)
  • Selective optical doping to predict the performance and reveal the origin of photocurrent peaks in quantum dots-in-a-well infrared photodetectors
  • 2009
  • Ingår i: INFRARED PHYSICS and TECHNOLOGY. - Exeter : Elsevier BV. - 1350-4495 .- 1879-0275. ; 52:6, s. 272-275
  • Tidskriftsartikel (refereegranskat)abstract
    • Resonant optical pumping across the band gap was used as artificial doping in InAs/In0.15Ga0.85As/GaAs quantum dots-in-a-well infrared photodetectors. Through efficient filling of the quantum dot energy levels by simultaneous optical pumping into the ground states and the excited states of the quantum dots, the response was increased by a factor of 10. Low temperature photocurrent peaks observed at 120 and 148 meV were identified as intersubband transitions emanating from the quantum dot ground state and the quantum dot excited state, respectively by a selective increase of the electron population in the different quantum dot energy levels.
  •  
20.
  • Horvath, Dragos, et al. (författare)
  • Design of a general-purpose European compound screening library for EU-OPENSCREEN
  • 2014
  • Ingår i: ChemMedChem. - : Wiley. - 1860-7179 .- 1860-7187. ; 9:10, s. 2309-2326
  • Tidskriftsartikel (refereegranskat)abstract
    • This work describes a collaborative effort to define and apply a protocol for the rational selection of a general-purpose screening library, to be used by the screening platforms affiliated with the EU-OPENSCREEN initiative. It is designed as a standard source of compounds for primary screening against novel biological targets, at the request of research partners. Given the general nature of the potential applications of this compound collection, the focus of the selection strategy lies on ensuring chemical stability, absence of reactive compounds, screening-compliant physicochemical properties, loose compliance to drug-likeness criteria (as drug design is a major, but not exclusive application), and maximal diversity/coverage of chemical space, aimed at providing hits for a wide spectrum of drugable targets. Finally, practical availability/cost issues cannot be avoided. The main goal of this publication is to inform potential future users of this library about its conception, sources, and characteristics. The outline of the selection procedure, notably of the filtering rules designed by a large committee of European medicinal chemists and chemoinformaticians, may be of general methodological interest for the screening/medicinal chemistry community. The selection task of 200K molecules out of a pre-filtered set of 1.4M candidates was shared by five independent European research groups, each picking a subset of 40K compounds according to their own in-house methodology and expertise. An in-depth analysis of chemical space coverage of the library serves not only to characterize the collection, but also to compare the various chemoinformatics-driven selection procedures of maximal diversity sets. Compound selections contributed by various participating groups were mapped onto general-purpose self-organizing maps (SOMs) built on the basis of marketed drugs and bioactive reference molecules. In this way, the occupancy of chemical space by the EU-OPENSCREEN library could be directly compared with distributions of known bioactives of various classes. This mapping highlights the relevance of the selection and shows how the consensus reached by merging the five different 40K selections contributes to achieve this relevance. The approach also allows one to readily identify subsets of target-or target-class-oriented compounds from the EU-OPENSCREEN library to suit the needs of the diverse range of potential users. The final EU-OPENSCREEN library, assembled by merging five independent selections of 40K compounds from various expert groups, represents an excellent example of a Europe-wide collaborative effort toward the common objective of building best-in-class European open screening platforms.
  •  
21.
  • Höglund, Linda, 1974-, et al. (författare)
  • Bias and temperature dependence of the escape processes in quantum dots-in-a-well infrared photodetectors
  • 2008
  • Ingår i: Applied Physics Letters. - New York : American Institute of Physics (AIP). - 0003-6951 .- 1077-3118. ; 93:10, s. 103501-
  • Tidskriftsartikel (refereegranskat)abstract
    • The performance of quantum dots-in-a-well infrared photodetectors (DWELL IPs) has been studied by means of interband and intersubband photocurrent measurements as well as dark current measurements. Using interband photocurrent measurements, substantial escape of electrons from lower lying states in the DWELL structure at large biases was revealed. Furthermore, a significant variation in the escape probability from energy states in the DWELL structure with applied bias was observed. These facts can explain the strong temperature and bias dependence of both photocurrent and dark currents in DWELL IPs.
  •  
22.
  • Höglund, Linda, 1974-, et al. (författare)
  • Bias mediated tuning of the detection wavelength in asymmetrical quantum dots-in-a-well infrared photodetectors
  • 2008
  • Ingår i: Applied Physics Letters. - New York : AIP Publishing. - 0003-6951 .- 1077-3118. ; 93:20
  • Tidskriftsartikel (refereegranskat)abstract
    • Bias-mediated tuning of the detection wavelength within the infrared wavelength region is demonstrated for quantum dots-in-a-well and dots-on-a-well infrared photodetectors. By positioning the InAs quantum dot layer asymmetrically in an 8 nm wide In0.15Ga0.85As/GaAs quantum well, a shift in the peak detection wavelength from 8.4 to 10.3 mu m was observed when reversing the polarity of the applied bias. For a dots-on-a-well structure, the peak detection wavelength was tuned from 5.4 to 8 mu m with small changes in the applied bias. These tuning properties could be essential for applications such as modulators and dual-color infrared detection.
  •  
23.
  •  
24.
  • Höglund, Linda, 1974-, et al. (författare)
  • Energy level scheme of InAs/InxGa1-xAs/GaAs quantum-dots-in-a-well infrared photodetector structures
  • 2010
  • Ingår i: Physical Review B. Condensed Matter and Materials Physics. - Woodbury, NY : American Physical Society. - 1098-0121 .- 1550-235X. ; 82:3, s. 035314-
  • Tidskriftsartikel (refereegranskat)abstract
    • A thorough investigation of quantum-dots-in-a-well structures for infrared photodetector applications has been performed employing different experimental techniques. The electronic structure of self-assembled InAs quantum dots embedded in an In0.15Ga0.85As/GaAs quantum well (QW) was deduced from photoluminescence (PL) and PL excitation (PLE) spectroscopy. From polarization-dependent PL it was revealed that the quantum dots hold two electron energy levels and two heavy-hole levels. Tunnel capacitance spectroscopy confirmed an electron energy level separation of about 50 meV, and additionally, that the conduction-band ground state and excited state of the dots are twofold and fourfold degenerates, respectively. Intersubband photocurrent spectroscopy, combined with simultaneous interband pumping of the dots, revealed a dominant transition at 150 meV (8.5 mu m) between the ground state of the quantum dots and the excited state of the QW. Results from detailed full three-dimensional calculations of the electronic structure, including effects of composition intermixing and interdot interactions, confirm the experimentally unravelled energy level scheme of the dots and well.
  •  
25.
  • Höglund, Linda, 1974-, et al. (författare)
  • Optical pumping as artificial doping in quantum dots-in-a-well infrared photodetectors
  • 2009
  • Ingår i: Applied Physics Letters. - New York : AIP Publishing. - 0003-6951 .- 1077-3118. ; 94:5, s. 053503-
  • Tidskriftsartikel (refereegranskat)abstract
    • Resonant optical pumping across the band gap was used as artificial doping in InAs/In0.15Ga0.85As/GaAs quantum dots-in-a-well infrared photodetectors. By selectively increasing the electron population in the different quantum dot energy levels, the low temperature photocurrent peaks observed at 120 and 148 meV, could be identified as intersubband transitions emanating from the quantum dot ground state and the quantum dot excited state, respectively. With efficient filling of the quantum dot energy levels through simultaneous optical pumping into the ground states and the excited states of the quantum dots, the response was increased by a factor of 10.
  •  
26.
  • Höglund, Linda, 1974-, et al. (författare)
  • Origin of photocurrent in lateral quantum dots-in-a-well infrared photodetectors
  • 2006
  • Ingår i: Applied Physics Letters. - New York : American Institute of Physics. - 0003-6951 .- 1077-3118. ; 88:21
  • Tidskriftsartikel (refereegranskat)abstract
    • Interband and intersubband transitions of lateral InAs/In0.15Ga0.85As dots-in-a-well quantum dot infrared photodetectors were studied in order to determine the origin of the photocurrent. The main intersubband transition contributing to the photocurrent (PC) was associated with the quantum dot ground state to the quantum well excited state transition. By a comparison between intersubband PC measurements and the energy level scheme of the structure, as deduced from Fourier transform photoluminescence (FTPL) and FTPL excitation spectroscopies, the main transition contributing to the PC was identified.
  •  
27.
  •  
28.
  •  
29.
  • Höglund, Linda, 1974-, et al. (författare)
  • Quantum dots-in-a-well infrared photodetectors for long wavelength infrared detection
  • 2006
  • Ingår i: Proceedings of SPIE. - Bellingham, Wash. : SPIE - International Society for Optical Engineering. - 9780819464996 ; 6401, s. 1-640109
  • Konferensbidrag (refereegranskat)abstract
    • We report on a quantum dots-in-a-well infrared photodetector (DWELL QDIP) grown by metal organic vapor phase epitaxy. The DWELL QDIP consisted of ten stacked InAs/In0.5Ga0.85As/GaAs QD layers embedded between n-doped contact layers. The density of the QDs was about 9 × 10 10 cm-2 per QD layer. The energy level structure of the DWELL was revealed by optical measurements of interband transitions, and from a comparison with this energy level scheme the origin of the photocurrent peaks could be identified. The main intersubband transition contributing to the photocurrent was associated with the quantum dot ground state to the quantum well excited state transition. The performance of the DWELL QDIPs was evaluated regarding responsivity and dark current for temperatures between 15 K and 77 K. The photocurrent spectrum was dominated by a LWIR peak, with a peak wavelength at 8.4 μm and a full width at half maximum (FWHM) of 1.1 μm. At an operating temperature of 65 K, the peak responsivity was 30 mA/W at an applied bias of 4 V and the dark current was 1.2×10-5 A/cm2. Wavelength tuning from 8.4 μm to 9.5 μm was demonstrated, by reversing the bias of the detector.
  •  
30.
  • Höglund, Linda, et al. (författare)
  • Studies of photocurrent and dark current in quantum dots-in-a-well infrared photodetectors
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • The performance of quantum dots-in-a-well infrared photodetectors (DWELL IPs) has been studied by means of interband and intersubband photocurrent measurements as well as dark current measurements. Using interband photocurrent measurements, substantial escape of electrons from lower lying states in the DWELL structure at large biases was revealed. Furthermore, a significant variation of the escape probability from energy states in the DVELL sturcture with voltage was observed. These facts could be possible explanations to the strong temperature and voltage dependence of hoth photocurrent and dark current in DWELL IPs. In a comparison between DWELL IPs and quantum well infrared photocdetectors (QWIPs), the dark current was shown to be considerably lower in DWELL IPs than in QWIPs, but alos the responsivity was low in comparison to QWIPs.
  •  
31.
  •  
32.
  •  
33.
  •  
34.
  • Höglund, Linda, et al. (författare)
  • Tuning of the detection wavelength in quantum dots-in-a-well infrared photodetectors
  • 2008
  • Ingår i: Proceedings of SPIE, 6940, Infrared Technology and Applications XXXIV, 694002. - : SPIE. - 9780819471314
  • Konferensbidrag (refereegranskat)abstract
    • In this study, bias mediated tuning of the detection wavelength within the infrared wavelength region is demonstrated for quantum dots-in-a-well (DWELL) infrared photodetectors. In DWELL structures, intersubband transitions in the conduction band occur from a discrete state in the quantum dot to a subband inthe quantum well. Compared to "conventional" quantum dot infrared photodetectors, where the transitions take place between different discrete bands in thequantum dots, new possibilities to tune the detection wavelength window are opened up, partly by varying the quantum dot energy levels and partly by adjusting the width and composition of the quantum well. In the DWELL structure used, an asymmetric positioning of the InAs quantum dot layer in a 8 nm wide In0.15Ga0.85As/GaAs QW has been applied which enables tuning of the peak detection wavelength within the long wavelength infrared (LWIR; 8 - 14 gm) region. When the applied bias was reversed, a wavelength shift from 8.5 to 9.5 mu m was observed for the peak position in the spectral response. For another DWELL structure, with a well width of 2 nm, the tuning range of the detector could be shifted from the medium wavelength infrared (MWIR; 3-5 mu m) region to the LWIR region. With small changes in the applied bias, the peak detection wavelength could be shifted from 5.1 to 8 mu m. These tuning properties ofDWELL structures could be essential for applications such as modulators and two-colour infrared detection. © (2008) COPYRIGHT SPIE--The International Society for Optical Engineering.
  •  
35.
  •  
36.
  •  
37.
  • Jelenkovic, Aline, et al. (författare)
  • Associations between birth size and later height from infancy through adulthood : An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project
  • 2018
  • Ingår i: Early Human Development. - : Elsevier BV. - 0378-3782 .- 1872-6232. ; 120, s. 53-60
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. Aim: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. Results: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14–4.25 cm and 0.18–0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. Conclusion: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.
  •  
38.
  •  
39.
  • Johansson, Per, 1966, et al. (författare)
  • Cerebrospinal fluid substance P concentrations are elevated in patients with Alzheimer's disease.
  • 2015
  • Ingår i: Neuroscience letters. - : Elsevier BV. - 1872-7972 .- 0304-3940. ; 609, s. 58-62
  • Tidskriftsartikel (refereegranskat)abstract
    • The neuropeptides substance P, orexin A (hypocretin-1) and neurotensin are signaling molecules that influence brain activity. We examined their cerebrospinal fluid (CSF) levels in a study population consisting of Alzheimer's disease (AD) dementia or mild cognitive impairment (MCI) diagnosed with AD dementia upon follow-up (n=32), stable MCI (SMCI, n=13), other dementias (n=15), and healthy controls (n=20). CSF substance P level was increased in AD patients compared to patients with other dementias and healthy controls (P<0.05 and P<0.01, respectively). Patients with other dementia or SMCI had lower CSF orexin A level than AD patients (both P<0.05) and marginally lower level than healthy controls (both P=0.05). CSF neurotensin level was similar in all groups. In the total study population (n=80), CSF substance P level correlated positively with CSF levels of T-tau and P-tau, and in AD patients (n=32), CSF substance P level correlated positively with CSF Aβ1-42 level. In conclusion, CSF substance P level was elevated in AD patients and correlated with CSF Aβ1-42 level, a well established marker of senile plaque pathology. The role of low CSF orexin A level in other dementias or SMCI needs to be explored in further studies.
  •  
40.
  • Johansson, Per, 1966, et al. (författare)
  • Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer's Disease.
  • 2017
  • Ingår i: Journal of Alzheimer's disease : JAD. - 1875-8908 .- 1387-2877. ; 59:3, s. 1017-1026
  • Tidskriftsartikel (refereegranskat)abstract
    • Apolipoprotein E (ApoE) has been extensively studied in Alzheimer's disease (AD), but little is known of apolipoprotein A-I (ApoA-I) in cerebrospinal fluid (CSF).Plasma lipids as well as ApoA-I and ApoE in plasma and CSF were determined and related to Mini-Mental State Examination (MMSE) score, APOE genotype, and CSF AD biomarkers.Consecutive patients with AD (n=29), stable mild cognitive impairment (n=13), other dementias (n=14), and healthy controls (n=18) were included at a single center.AD patients had higher plasma triglycerides and lower CSF ApoA-I concentration than controls (both p<0.05). CSF ApoE concentration was reduced in other dementias (p<0.01). In AD as well as other dementias, the ratios between CSF and plasma concentrations of both ApoA-I and ApoE were lower than those in the controls. ApoA-I and ApoE in plasma and CSF were not influenced by APOEɛ4 allele distribution. In the total study population (n=74), CSF ApoA-I correlated positively with MMSE score (r=0.26, p<0.05) and negatively with CSF P-tau (r=-0.25, p<0.05). CSF ApoE correlated positively with CSF concentrations of T-tau and P-tau in the total study population and in AD patients.CSF ApoA-I was reduced in AD patients and associated with measures of cognitive function and AD disease status. The mechanisms underlying the decreased CSF:plasma ratios of ApoA-I and ApoE in AD and other dementias need to be explored in further studies.
  •  
41.
  • Johansson, Per, 1966, et al. (författare)
  • Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment.
  • 2017
  • Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 12:5
  • Tidskriftsartikel (refereegranskat)abstract
    • The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples.Consecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel.After correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of β-amyloid1-42 (Aβ1-42) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01).Most cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI.
  •  
42.
  • Johansson, Per, et al. (författare)
  • Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's disease
  • 2013
  • Ingår i: Psychoneuroendocrinology. - : Elsevier BV. - 1873-3360 .- 0306-4530. ; 38:7, s. 1058-1066
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Little is known of the association between thyroid hormones in the central nervous system and Alzheimer's disease (AD). We determined thyroid hormone levels in serum and cerebrospinal fluid (CSF) in a well-defined homogeneous mono-center population. Methods: Fifty-nine consecutive patients under primary evaluation for cognitive impairment were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n = 31), patients with stable MCI (SMCI, n = 13), patients with other dementias (n = 15), and healthy controls (n = 19). Thyroid hormones in serum and CSF and AD biomarkers in CSF were analyzed using established immunochemical assays. Cognitive impairment was estimated using mini-mental state examination (MMSE). Results: Serum levels of free and total thyroxine (T4) and triiodothyronine (T3) were similar in all groups whereas a marginal increase in serum thyroid-stimulating hormone (TSH) level was observed in the AD patients. The CSF level of total T4 was decreased in patients with AD and other dementias compared to SMCI (both P = 0.01) and healthy controls (both P = 0.001), whereas CSF levels of TSH and total T3 were unchanged. In the total study population, CSF total 14 level correlated positively with MMSE score (r = 0.26, P < 0.05) and negatively with CSF total-tau (T-Tau) level (r = -0.23, P < 0.05). Conclusion: Patients with AD as well as other dementias had signs of mild brain hypothyroidism, which could only to a small extent be detected in serum values. (C) 2012 Elsevier Ltd. All rights reserved.
  •  
43.
  • Karami, Azadeh, et al. (författare)
  • Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease
  • 2015
  • Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:11, s. 1316-1328
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: The extensive loss of central cholinergic functions in Alzheimer's disease (AD) brain is linked to impaired nerve growth factor (NGF) signaling. The cardinal cholinergic biomarker is the acetylcholine synthesizing enzyme, choline acetyltransferase (ChAT), which has recently been found in cerebrospinal fluid (CSF). The purpose of this study was to see if EC-NGF therapy will alter CSF levels of cholinergic biomarkers, ChAT, and acetylcholinesterase. Method: Encapsulated cell implants releasing NGF (EC-NGF) were surgically implanted bilaterally in the basal forebrain of six AD patients for 12 months and cholinergic markers in CSF were analyzed. Results: Activities of both enzymes were altered after 12 months. In particular, the activity of soluble ChAT showed high correlation with cognition, CSF tau and amyloid-beta, in vivo cerebral glucose utilization and nicotinic binding sites, and morphometric and volumetric magnetic resonance imaging measures. Discussion: A clear pattern of association is demonstrated showing a proof-of-principle effect on CSF cholinergic markers, suggestive of a beneficial EC-NGF implant therapy.
  •  
44.
  •  
45.
  • Khan, Zahidul, et al. (författare)
  • Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy.
  • 2010
  • Ingår i: Neuro-Oncology. - : Oxford University Press (OUP). - 1523-5866 .- 1522-8517. ; 12, s. 549-558
  • Tidskriftsartikel (refereegranskat)abstract
    • The prognosis for malignant gliomas remains poor, and new treatments are urgently needed. Targeted suicide gene therapy exploits the enzymatic conversion of a prodrug, such as a nucleoside analog, into a cytotoxic compound. Although this therapeutic strategy has been considered a promising regimen for central nervous system (CNS) tumors, several obstacles have been encountered such as inefficient gene transfer to the tumor cells, limited prodrug penetration into the CNS, and inefficient enzymatic activity of the suicide gene. We report here the cloning and successful application of a novel thymidine kinase 1 (TK1) from the tomato plant, with favorable characteristics in vitro and in vivo. This enzyme (toTK1) is highly specific for the nucleoside analog prodrug zidovudine (azidothymidine, AZT), which is known to penetrate the blood-brain barrier. An important feature of toTK1 is that it efficiently phosphorylates its substrate AZT not only to AZT monophosphate, but also to AZT diphosphate, with excellent kinetics. The efficiency of the toTK1/AZT system was confirmed when toTK1-transduced human glioblastoma (GBM) cells displayed a 500-fold increased sensitivity to AZT compared with wild-type cells. In addition, when neural progenitor cells were used as delivery vectors for toTK1 in intracranial GBM xenografts in nude rats, substantial attenuation of tumor growth was achieved in animals exposed to AZT, and survival of the animals was significantly improved compared with controls. The novel toTK1/AZT suicide gene therapy system in combination with stem cell-mediated gene delivery promises new treatment of malignant gliomas.
  •  
46.
  • Lindgren, Ola, et al. (författare)
  • On the importance of the therapist in psychotherapy : A summary of current research
  • 2010
  • Ingår i: International Forum of Psychoanalysis. - : Routledge. - 0803-706X .- 1651-2324. ; 19:4, s. 224-229
  • Tidskriftsartikel (refereegranskat)abstract
    • The American Psychological Association's Presidential Task Force on Evidence-Based Practice articulates a decision-making process based on the integration of the best available research, clinical expertise, and patient characteristics. The treatment method, the individual psychotherapist, the treatment relationship, and the patient are all vital contributors to successful psychotherapy. Several studies have shown that the variation in treatment effect among psychotherapists using the same method is greater than the variation in treatment effect among different methods. This outcome pleads for a comprehensive psychotherapist-related g-factor of psychotherapy. In terms of decision-making for health-care institutions and clinical practices, it would seem wise not to separate the psychotherapist, the patient, or the relationship from the method as there seem to be extensive effects relative to the interaction among these parameters. Parallel to a growing knowledge of evidence-based methods, there is still a decisive lack of scientific knowledge about these interactions
  •  
47.
  • Lindgren, Ola, et al. (författare)
  • Patients’ thoughts on effective psychotherapy
  • 2014
  • Ingår i: The European Journal for Qualitative Research in Psychotherapy. - 1756-7599. ; 7, s. 4-21
  • Tidskriftsartikel (refereegranskat)abstract
    • Earlier studies of patients’ experiences in psychotherapy identify relationship factors as being significant forpatients. Our aim in this study conducted in accord with grounded theory, was to explore in some depth patients’thoughts about what is effective in psychotherapy and thereby increase our knowledge about the processof psychotherapy from a patient perspective. Data were collected in open interviews that provided rich andvaried information. Several informants had been in more than one therapy and thus, eight interviews provideddata about sixteen psychotherapies. The core concept that emerged from the data was that of the therapist’sresponsive acceptance. This concept provides an answer to the question “What do patients think is effective inpsychotherapy?” If the therapist is responsive and accepting, the mutual interplay between the patient and thetherapist becomes productive and collaborative. On the other hand, if responsive acceptance falters, the wholetherapy process is at risk.
  •  
48.
  • Lindgren, Ola, et al. (författare)
  • Psykoterapins "g-faktor" : Sammanfattning av aktuell forskning
  • 2009
  • Ingår i: Läkartidningen. - Stockholm : Läkartidningen Förlag AB. - 0023-7205 .- 1652-7518. ; 106:37, s. 2285-2288
  • Tidskriftsartikel (refereegranskat)abstract
    • Flera studier har visat att variationen i behandlingsresultat för olika psykoterapeuter inom samma terapimetod är betydligt större än variationen mellan olika terapimetoder.Mycket talar för att psyko terapeutisk behandling rymmer en metodövergripande »g-faktor« som snarare hör ihop med psykoterapeuten än med metoden.Det finns väsentliga luckor i kunskapen om interaktions effekter mellan psykoterapi metod, psykoterapeut, patientkaraktäristika, behandlingsrelation och kontext.Man bör vara uppmärksam på risken för ensidighet i implementering av enskilda psykoterapeutiska metoder på bred front inom hälso- och sjukvården.The American Psychological Associations Presidential Task Force on Evidence-Based Practice articulates a decision-making process based on the integration of the best available research, clinical expertise and patient characteristics. The treatment method, the individual psychotherapist, the treatment relationship and the patient are all vital contributors to a successful psychotherapy. Several studies have shown that the variation in treatment effect among psychotherapists using the same method is greater than the variation among different methods. This outcome pleads for a comprehensive psychotherapist-related g-factor of psychotherapy. In terms of decision-making for healthcare institutions and clinical practice, it would seem wise not to separate the psychotherapist, the patient or the relationship from the method as there seem to be extensive effects from interaction among these parameters. Parallel to a growing knowledge of evidence-based methods, there is still a decisive lack of scientific knowledge about these interactions
  •  
49.
  • Lindgren, Ola, et al. (författare)
  • Renewing experience : Therapists' Thoughts on What is Effective in Psychotherapy
  • 2012
  • Ingår i: European journal for qualitative research in psychotherapy. - 1756-7599. ; :6, s. 1-7
  • Tidskriftsartikel (refereegranskat)abstract
    • In this qualitative study, nine psychotherapists with different theoretical approaches were interviewed about their thoughts on what is effective in their work. Data was collected and analyzed according to Grounded Theory. The results are presented as a grounded theory of therapists' thoughts on what is effective in psychotherapy. The theory consists of a core category, Renewing Experience, its subcategories and their subsequent properties. The therapists' efforts in psychotherapy are to use the relationship with the patient as well as psychotherapy techniques available to cause the patient to experience something new. New experiences in psychotherapy add to and place earlier life experiences in a new perspective. If the new experiences are related to the patient's central issues, they can modify and renew existing and maladaptive conceptions of reality and make new life alternatives available to patients. Renewing Experience is a cumulative process where the therapist's ability to individualize interplay is decisive.
  •  
50.
  • Lindgren, Ola, 1953- (författare)
  • Terapeuters och patienters tankar om vad som är verksamt i individuell psykoterapi
  • 2011
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Det övergripande syftet för denna licentiatuppsats är att utforska psykoterapeuters och patienters tankar om vad som är verksamt i individuell psykoterapi med fokus på deras egna erfarenheter av psykoterapeutiskt arbete. Som metod för datainsamling och analys valdes grounded theory i båda de ingående studierna.I studie 1 intervjuades psykoterapeuter, legitimerade för individuell psykoterapi. Sammanlagt nio informanter deltog i studien, både män och kvinnor med olika yrkesbakgrund och med olika psykoterapeutisk inriktning.Ett centralt begrepp, förnyande erfarenhet, utvecklades ur data. Förnyande erfarenhet är en process där terapeuten och patienten i samarbete och dialog försöker att skapa situationer där patienten gör erfarenheter som ifrågasätter eller utmanar tidigare erfarenheter som patienten har eller ger ett nytt perspektiv på tidigare erfarenheter som gör dem mer begripliga och hanterbara. Förnyande erfarenhet leder till att patientens upplevelsevärld och beteende förändras i riktning mot ett ökat psykiskt välbefinnande.I studie 2 intervjuades åtta personer som gått i individuell psykoterapi av olika längd och teoretisk inriktning hos legitimerad psykoterapeut. De bidrog med data om sexton psykoterapier eftersom flera av dem hade erfarenhet av mer än en psykoterapi.Det centrala begrepp som utvecklades ur data var terapeutens lyhörda acceptans. Lyhördhet innebär att terapeuten har en förmåga att visa sig känslig för patientens behov och känslomässiga tillstånd och att ge gensvar på ett adekvat och konstruktivt sätt. Acceptans representerar en stödjande och icke-dömande atmosfär och terapeutens tolerans, välvilja och förstående inställning.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-50 av 74
Typ av publikation
tidskriftsartikel (44)
konferensbidrag (20)
annan publikation (3)
bokkapitel (2)
licentiatavhandling (2)
rapport (1)
visa fler...
bok (1)
doktorsavhandling (1)
visa färre...
Typ av innehåll
refereegranskat (62)
övrigt vetenskapligt/konstnärligt (11)
populärvet., debatt m.m. (1)
Författare/redaktör
Almqvist, S (17)
Asplund, C. (13)
Wang, Q. (12)
Andersson, J. Y. (11)
Holtz, Per-Olof, 195 ... (10)
Malm, H. (10)
visa fler...
Holtz, Per-Olof (8)
Smuk, S. (8)
Almqvist, Per (8)
Blennow, Kaj, 1958 (7)
Pettersson, Håkan (6)
Almqvist, Erik G. (6)
Pettersson, H (5)
Zetterberg, Henrik, ... (5)
Wallin, Anders, 1950 (5)
Svensson, Johan, 196 ... (5)
Pettersson, Håkan, 1 ... (5)
Almqvist, Susanne (5)
Karlsson, Fredrik (4)
Wahlund, Lars-Olof (4)
Hellström, Per-Erik, ... (4)
Wang, Qin (4)
Andersson, Jan Y. (4)
Pistol, Mats Erik (4)
Almqvist, Catarina (4)
Artursson, Per (4)
Lindgren, Ola (4)
Östman, Leif (4)
Johansson, Per, 1966 (4)
Andreasson, Ulf, 196 ... (4)
Almqvist, Jonas (4)
Asplund, Carl (4)
Linderoth, Bengt (4)
Folkesson, Per, 1946 ... (4)
Ramos Santesmases, D ... (4)
Evans, D. (3)
Eriksdotter, Maria (3)
Wahlberg, Lars (3)
Lundbäck, Thomas (3)
Ivanov, R. (3)
Almqvist, Helena (3)
Axelsson, Hanna (3)
Wickman, Per-Olof, 1 ... (3)
Lind, Göran (3)
Höglund, Linda (3)
Almqvist, Per M. (3)
Delmas, M. (3)
Becanovic, S. (3)
Costard, E. (3)
Lind, Goran (3)
visa färre...
Lärosäte
Linköpings universitet (20)
Uppsala universitet (18)
Lunds universitet (16)
Göteborgs universitet (13)
Karolinska Institutet (13)
Högskolan i Halmstad (11)
visa fler...
Umeå universitet (5)
Kungliga Tekniska Högskolan (5)
Stockholms universitet (5)
Karlstads universitet (5)
Jönköping University (3)
Mälardalens universitet (2)
Örebro universitet (1)
Högskolan i Skövde (1)
Chalmers tekniska högskola (1)
Högskolan i Borås (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (67)
Svenska (7)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (26)
Naturvetenskap (21)
Samhällsvetenskap (17)
Teknik (11)
Humaniora (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy