| 1. |
- de Rojas, I., et al.
(författare)
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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
- 2021
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
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| 2. |
- Koundouri, P., et al.
(författare)
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Methodology for Integrated Socio-economic Assessment of Multi-use Offshore Platforms.
- 2017
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Ingår i: In: Koundouri P. (eds) The Ocean of Tomorrow. Environment & Policy, vol 56. Springer, Cham. - 9783319557700 ; , s. 11-26
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter presents the methodology employed for the Integrated Socio-Economic Assessment (MISEA) of different designs of Multi-Use Offshore Platforms (MUOPs). The methodology allows for the identification, the valuationand the assessment of the potential impacts and their magnitude. The analysis considers a number of feasible designs of MUOP investments, and the likely responsesof those impacted by the investment project. The approach provides decision-makers with a valuable tool to assess whether a MUOP project increases the overall social welfare and hence should be undertaken. This is performed under alternative specifications regarding platform design, the discount rate and the stream of net benefits, if a Cost-Benefit Analysis (CBA) is to be followed or a sensitivity analysis of selected criteria in a Multi-Criteria Decision Analysis (MCDA) framework. Themethodology can support the implementation of policies aiming at achieving a goodenvironmental status of the EU’s marine waters and the protection of the resource base upon which marine-related economic and social activities depend.
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| 3. |
- Moussas, X., et al.
(författare)
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The gears of the Antikythera Mechanism : an educational pathfinder to the solar system
- 2011
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Ingår i: IAU Symposium.
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Konferensbidrag (refereegranskat)abstract
- The Antikythera Mechanism is the most sophisticated extant ancient astronomical instrument and analogue computer known and was assembled sometime between 150 and 100 BCE, almost a century after the death of Archimedes. The mechanism has a great educational potential as it appeals to inquiring minds as an astonishing artefact of science and technology. The latest research findings reveal significant cultural and social functions in its operations. This astonishing astronomical instrument has a clear interdisciplinary valueand it has that it may be used as an educational medium, to engage the general public, and especially to attract students both to/from exact sciences and to/from the humanities. The astronomical and technical knowledge embedded in the mechanism can also be used to introduce some aspects of modern science through the unknown technological achievements of Hellenic antiquity.
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| 5. |
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| 6. |
- Cassetta, L, et al.
(författare)
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Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation
- 2020
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Ingår i: Journal for immunotherapy of cancer. - : BMJ. - 2051-1426. ; 8:2
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Tidskriftsartikel (refereegranskat)abstract
- Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes myeloid cells with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood of patients with several malignant and non-malignant diseases. So far, direct comparison of MDSC across different diseases and Centers is hindered by technical pitfalls and a lack of standardized methodology. To overcome this issue, we formed a network through the COST Action Mye-EUNITER (www.mye-euniter.eu) with the goal to standardize and facilitate the comparative analysis of human circulating MDSC in cancer, inflammation and infection. In this manuscript, we present the results of the multicenter study Mye-EUNITER MDSC Monitoring Initiative, that involved 13 laboratories and compared circulating MDSC subsets across multiple diseases, using a common protocol for the isolation, identification and characterization of these cells.MethodsWe developed, tested, executed and optimized a standard operating procedure for the isolation and immunophenotyping of MDSC using blood from healthy donors. We applied this procedure to the blood of almost 400 patients and controls with different solid tumors and non-malignant diseases. The latter included viral infections such as HIV and hepatitis B virus, but also psoriasis and cardiovascular disorders.ResultsWe observed that the frequency of MDSC in healthy donors varied substantially between centers and was influenced by technical aspects such as the anticoagulant and separation method used. Expansion of polymorphonuclear (PMN)-MDSC exceeded the expansion of monocytic MDSC (M-MDSC) in five out of six solid tumors. PMN-MDSC expansion was more pronounced in cancer compared with infection and inflammation. Programmed death-ligand 1 was primarily expressed in M-MDSC and e-MDSC and was not upregulated as a consequence of disease. LOX-1 expression was confined to PMN-MDSC.ConclusionsThis study provides improved technical protocols and workflows for the multi-center analysis of circulating human MDSC subsets. Application of these workflows revealed a predominant expansion of PMN-MDSC in solid tumors that exceeds expansion in chronic infection and inflammation.
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| 7. |
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| 8. |
- Anastasiou, Alexandros, et al.
(författare)
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Are all supergravity theories Yang-Mills squared?
- 2018
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Ingår i: Nuclear Physics B. - : Elsevier. - 0550-3213 .- 1873-1562. ; 934, s. 606-633
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Tidskriftsartikel (refereegranskat)abstract
- Using simple symmetry arguments we classify the ungauged D = 4, N = 2 supergravity theories, coupled to both vector and hyper multiplets through homogeneous scalar manifolds, that can be built as the product of N = 2 and N= 0 matter-coupled Yang-Mills gauge theories. This includes all such supergravities with two isolated exceptions: pure supergravity and the T-3 model.
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| 9. |
- Anastasiou, Alexandros, et al.
(författare)
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Twin supergravities from Yang-Mills theory squared
- 2017
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Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 96:2
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Tidskriftsartikel (refereegranskat)abstract
- We consider "twin supergravities"-pairs of supergravities with N+ and N- supersymmetries, N+ > N-, with identical bosonic sectors-in the context of tensoring super Yang-Mills multiplets. It is demonstrated that the pairs of twin supergravity theories are related through their left and right super YangMills factors. This procedure generates newtheories from old ones. In particular, the matter coupled N(-)twins in D = 3, 5, 6 and the N- = 1 twins inD = 4 have not, as far as we are aware, been obtained previously using the double-copy construction, adding to the growing list of double-copy constructible theories. The use of fundamental matter multiplets in the double-copy construction leads us to introduce a bifundamental scalar that couples to the well-known biadjoint scalar field. It is also shown that certain matter coupled supergravities admit more than one factorization into left and right super Yang-Mills-matter theories.
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| 10. |
- Csapo, A., et al.
(författare)
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Multimodal conversational interaction with a humanoid robot
- 2012
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Ingår i: 3rd IEEE International Conference on Cognitive Infocommunications, CogInfoCom 2012 - Proceedings. - : IEEE. - 9781467351874 ; , s. 667-672
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Konferensbidrag (refereegranskat)abstract
- The paper presents a multimodal conversational interaction system for the Nao humanoid robot. The system was developed at the 8th International Summer Workshop on Multimodal Interfaces, Metz, 2012. We implemented WikiTalk, an existing spoken dialogue system for open-domain conversations, on Nao. This greatly extended the robot's interaction capabilities by enabling Nao to talk about an unlimited range of topics. In addition to speech interaction, we developed a wide range of multimodal interactive behaviours by the robot, including face-tracking, nodding, communicative gesturing, proximity detection and tactile interrupts. We made video recordings of user interactions and used questionnaires to evaluate the system. We further extended the robot's capabilities by linking Nao with Kinect.
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| 11. |
- Csapo, A., et al.
(författare)
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Open-Domain Conversation with a NAO Robot
- 2012
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Ingår i: 3rd International Conference on Cognitive Infocommunications (CogInfoCom 2012). - Kosice.
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Konferensbidrag (refereegranskat)abstract
- In this demo, we present a multimodal conversationsystem, implemented using a Nao robot and Wikipedia. The system was developed at the 8th International Workshop on Multimodal Interfaces in Metz, France, 2012. The system is based on an interactive, open-domain spoken dialogue systemcalled WikiTalk, which guides the user through conversations based on the link structure of Wikipedia. In addition to speech interaction, the robot interacts with users by tracking their faces and nodding/gesturing at key points of interest within the Wikipedia text. The proximity detection capabilities of the Nao,as well as its tactile sensors were used to implement context-based interrupts in the dialogue system.
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| 12. |
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| 13. |
- Michelakos, Theodoros, et al.
(författare)
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Serum Folate and B12 Levels in Association With Cognitive Impairment Among Seniors : Results From the VELESTINO Study in Greece and Meta-Analysis
- 2013
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Ingår i: Journal of Aging and Health. - : SAGE Publications. - 0898-2643 .- 1552-6887. ; 25:4, s. 589-616
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( > 65 years) residing in Velestino, Greece. Method: Serum measurements and Mini-Mental State Examination (MMSE) assessments were available for 593 Velestinians. In addition, 12 studies availing data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were identified following a search algorithm; pooled effect estimates were derived. Results: Cognitive impairment (MMSE < 24) among Velestenians was associated with lower education level in both genders; decreased social activity, depressive symptoms and low folate levels in males; older age in females. Meta-analyses showed an adverse effect of low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40). Discussion: Low folate levels are associated with cognitive impairment of seniors; underlying pathophysiological mechanisms should be further explored.
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| 14. |
- Papadopoulos, FC, et al.
(författare)
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Prevalence and correlates of depression in late life : a population based study from a rural Greek town
- 2005
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Ingår i: International Journal of Geriatric Psychiatry. - : Wiley. - 0885-6230 .- 1099-1166. ; 20:4, s. 350-357
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundDepression in late life is common and has serious consequences on function, medical co-morbidity, quality of life, and use of medical services.ObjectiveTo estimate the age- and gender-specific prevalence of depression among people over 60 years of age, and to examine correlates of depression, in particular the relationship between depression and cognitive impairment.MethodFrom a total of 965 inhabitants, aged over 60 years, in Velestino, a rural town in central Greece, 608 were accessible and constituted the target population. During a five-month period in 2000, a trained health visitor interviewed all study participants. The interview covered socio-demographic characteristics, medical history, and administration of the 15-question Geriatric Depression Scale (GDS-15) and the Mini Mental Scale Examination instrument (MMSE).ResultsThe prevalence of mild or more severe depression (GDS≥7) was 27%, while the prevalence of moderate to severe depression (GDS≥11) was 12%. Increasing age, female gender, lower education, and being currently unmarried were associated with higher risk of depression in univariate regression models, but these associations disappeared after controlling for cognitive function, except for the association with marital status. Cognitive impairment was strongly associated with increased risk for depression. The co-morbid presence of digestive, neurological and heart conditions was also associated with increased risk for depression, while cancer was not.ConclusionIn a rural Greek area, the prevalence of depression in late life is high. Depression was more common among unmarried individuals, those with significant cognitive impairment, and in association with specific medical conditions.
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