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- Sagi, JC, et al.
(författare)
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Pharmacogenetics of the Central Nervous System-Toxicity and Relapse Affecting the CNS in Pediatric Acute Lymphoblastic Leukemia
- 2021
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 13:10
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Tidskriftsartikel (refereegranskat)abstract
- Despite improving cure rates in childhood acute lymphoblastic leukemia (ALL), therapeutic side effects and relapse are ongoing challenges. These can also affect the central nervous system (CNS). Our aim was to identify germline gene polymorphisms that influence the risk of CNS events. Sixty single nucleotide polymorphisms (SNPs) in 20 genes were genotyped in a Hungarian non-matched ALL cohort of 36 cases with chemotherapy related acute toxic encephalopathy (ATE) and 544 controls. Five significant SNPs were further analyzed in an extended Austrian-Czech-NOPHO cohort (n = 107 cases, n = 211 controls) but none of the associations could be validated. Overall populations including all nations’ matched cohorts for ATE (n = 426) with seizure subgroup (n = 133) and posterior reversible encephalopathy syndrome (PRES, n = 251) were analyzed, as well. We found that patients with ABCB1 rs1045642, rs1128503 or rs2032582 TT genotypes were more prone to have seizures but those with rs1045642 TT developed PRES less frequently. The same SNPs were also examined in relation to ALL relapse on a case-control matched cohort of 320 patients from all groups. Those with rs1128503 CC or rs2032582 GG genotypes showed higher incidence of CNS relapse. Our results suggest that blood-brain-barrier drug transporter gene-polymorphisms might have an inverse association with seizures and CNS relapse.
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- Kalogirou, S., et al.
(författare)
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Spatial and temporal distribution of narwal shrimp Plesionika narval (Decapoda, Pandalidae) in the Aegean Sea (eastern Mediterranean Sea)
- 2017
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Ingår i: Regional Studies in Marine Science. - : Elsevier BV. - 2352-4855. ; 16, s. 240-248
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Tidskriftsartikel (refereegranskat)abstract
- In the Aegean Sea the trap fishery for narwal shrimp, Plesionika narval, contributes to social and cultural cohesion of local fishery communities. Spatial and temporal distribution patterns of narwal shrimp was studied during an annual cycle, including catch per unit effort (CPUE), sex ratio and proportion of ovigerous females in the population. Shrimps were sampled at five localities within the depth range of 10 to 170 m. Catch per unit effort increased during the summer period at all depths, when seawater temperature increase. Differences in CPUE were observed between depths, with highest catches at depths below 70 m. The proportion of females decreased significantly with depth, a pattern especially evident during the summer period (May to August), indicating a migration of females to shallower waters. Significant higher abundance of ovigerous females was observed during the period May to October, concurrently with a vertical migration of females to warmer waters. To further support this pattern, the proportion of ovigerous individuals among females increased with decreased depth at all seasons. We suggest that the findings of our study have significant implications to current and future management of narwal shrimp in the Mediterranean Sea. © 2017 Elsevier B.V.
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