| 1. |
- DAWODY, JAZAER, 1959, et al.
(författare)
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E4-Mistra, a research program for the development of an energy efficient low emission exhaust aftertreatment system for heavy duty vehicles
- 2012
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Ingår i: World Renewable Energy Forum, WREF 2012, Including World Renewable Energy Congress XII and Colorado Renewable Energy Society (CRES) Annual Conference. - : American Solar Energy Society. - 9781622760923 ; , s. 4530-4536
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Konferensbidrag (refereegranskat)abstract
- This paper presents a unique system approach applied in a joint academic - industrial research program, E4 Mistra, to reach the goals of energy efficiency and low emissions exhaust aftertreatment system for heavy duty vehicles. The high energy efficiency is achieved by heat recuperation, on-board hydrogen production for use in both an auxiliary power unit and for NOx reduction and by finding new solutions for making the after-treatment system active at low exhaust temperatures. To reach low particulate emissions a mechanical filter using a sintered metal filter is developed. Low NOx emissions are achieved by an efficient NOx reduction catalyst. The system is based on four technological advances: Thermoelectric material s for heat recuperation, catalytic reduction of NOx over innovative catalyst substrates using hydrocarbons from the fuel and H2 from a high efficiency fuel reformer, and particulate filtration over a porous metal filter.
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| 2. |
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| 3. |
- DAWODY, JAZAER, 1959, et al.
(författare)
-
An integrated system for energy-efficient exhaust aftertreatment for heavy-duty vehicles
- 2015
-
Ingår i: Renewable Energy in the Service of Mankind. - Cham : Springer International Publishing. - 9783319177779 - 9783319177762 ; , s. 133-143
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- © Springer International Publishing Switzerland 2015. This chapter presents a unique system approach applied in a joint academic- industrial research programme, E4 Mistra, to attain the goals of high energy efficiency and low emissions in an exhaust aftertreatment system for heavy-duty vehicles. The high energy efficiency is achieved by heat recuperation, onboard hydrogen production for NOx reduction, and by finding new solutions for making the aftertreatment system active at low exhaust temperatures. To reach low particulate emissions, a mechanical filter using a sintered metal powder is developed and coated with catalytic material to improve the soot oxidation efficiency. Low NOx emissions are achieved by an efficient NOx reduction catalyst. The integrated E4 Mistra system comprises four technological advances: thermoelectric (TE) materials for heat recuperation, catalytic reduction of NOx over innovative catalyst substrates using either the onboard diesel or biodiesel, H2 from a high-efficiency fuel reformer, and particulate filtration over a porous metal filter. The TE materials are used in a TE generator (TEG) which converts thermal energy into electricity. The TEG is used to recuperate heat from the exhaust-gas recirculation (EGR) circuit of heavy-duty trucks and is expected to generate ~1 kW electric power from 20 kW heat in the exhaust gas. The TEG is integrated in a plate heat exchanger (HEX) designed particularly for this application. Apart from the knowledge and experiences in TEG and heat exchange technologies, a thorough fluid dynamics and TE analysis are performed in this project to understand the governing processes and optimize the system accordingly. The components of the E4 Mistra system are explained in the chapter in addition to test results, which show the system's capacity for H2 production, NOx conversion, particulate matter filtration and soot oxidation, and finally electric power generation via heat recuperation from the exhaust gas using the developed TEG-HEX system.
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| 4. |
- Andersson, Anders, 1983-, et al.
(författare)
-
SIREN : sound generation for vehicle simulation
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The ViP Simulator Sound Renderer (SIREN) software has been created as a means to facilitate generation and playback of audio signals in driving simulators. Siren is a modular, scalable program with a plug-in based infrastructure. The included plug-ins offer sound file playback, sound stream playback and spatialization possibilities. Required additional functionality can be added by creating custom plug-ins. Siren by default relies on the OpenAL library for spatialization and on Csound for sound stream generation. Other spatialization and generation software can be used by replacing the corresponding API modules. Siren is implemented in the new Simulator IV as well as in Simulator III at VTI and will also be implemented in Simulator II in the immediate future. Experimental implementations have been tested in the VTI Foerst simulator running solely under the Microsoft Windows operating system. Volvo Trucks has a trial version implemented in their simulator and has made some local customization. The current sound models implemented through Siren in the VTI simulators consist of real-time synthesis of sound based on measurements performed in real vehicles (car and truck) on the Volvo test track. The resulting sound has been validated through corresponding measurements performed inside the simulator cabins as well as through informal listening by experienced drivers.
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| 5. |
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| 6. |
- Berland, Kristian, 1983, et al.
(författare)
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Temperature stability of intersubband transitions in AlN/GaN quantum wells
- 2010
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 97:4, s. 043507-
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Tidskriftsartikel (refereegranskat)abstract
- Temperature dependence of intersubband transitions in AlN/GaN multiple quantum wells grown with molecular beam epitaxy is investigated both by absorption studies at different temperatures and modeling of conduction-band electrons. For the absorption study, the sample is heated in increments up to 400 degrees C. The self-consistent Schroumldinger-Poisson modeling includes temperature effects of the band gap and the influence of thermal expansion on the piezoelectric field. We find that the intersubband absorption energy decreases only by similar to 6 meV at 400 degrees C relative to its room temperature value.
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| 7. |
- Ive, Tommy, 1968, et al.
(författare)
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Design and Fabrication of AlN/GaN Heterostructures for Intersubband Technology
- 2012
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Ingår i: Japanese Journal of Applied Physics. - 1347-4065 .- 0021-4922. ; 51:1, s. Article Number: 01AG07 -
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Tidskriftsartikel (refereegranskat)abstract
- We have used models based on the effective-mass approximation and Schrodinger-Poisson to design AlN/GaN multiple quantum well structures for intersubband transitions between two or three energy levels. The structures were realized by molecular beam epitaxy and the surface morphology and structural quality were investigated. We also investigated GaN waveguides that were fabricated using standard cleanroom techniques. Our work is focused on the various challenges associated to the fabrication of quantum cascade lasers based on group III-nitrides. These challenges are discussed in the light of our results.
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| 8. |
- Joffrin, E., et al.
(författare)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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| 9. |
- Nyberg, Lars, 1966-, et al.
(författare)
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Individual differences in brain aging : heterogeneity in cortico-hippocampal but not caudate atrophy rates
- 2023
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Ingår i: Cerebral Cortex. - : Oxford University Press. - 1047-3211 .- 1460-2199. ; 33:9, s. 5075-5081
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Tidskriftsartikel (refereegranskat)abstract
- It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
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| 10. |
- Stattin, Martin, 1983, et al.
(författare)
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Waveguides for nitride based quantum cascade lasers
- 2011
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Ingår i: Physica Status Solidi (C) Current Topics in Solid State Physics. - : Wiley. - 1610-1642 .- 1862-6351. ; 8:7-8, s. 2357-2359
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Tidskriftsartikel (refereegranskat)abstract
- Waveguide designs for AlGaN-based near-infrared quantum cascade lasers are investigated using a finite-difference method mode solver. Because of the negligibly small refractive index difference between the AlN/GaN/AlGaN gain region and the surrounding AlGaN current injection and extraction layers, a low refractive index substrate (sapphire) and a low refractive index dielectric (SiO2) are used for vertical confinement of the optical field. A ridge waveguide with an off-center contact metallization is used for lateral confinement. The off-center contact allows for the propagation of a TM mode with low metal induced loss and sufficient optical confinement in the gain region. A viable waveguide design with a metal-induced loss of 6.1 cm-1 and a confinement factor of 0.52 is demonstrated.
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| 11. |
- Stattin, Martin, 1983, et al.
(författare)
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Waveguides for Nitride Based Quantum Cascade Lasers
- 2010
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Ingår i: International Workshop on Nitride Semiconductors (IWN2010), Tampa, Florida, U.S.A., September 19 – 24, 2010.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 12. |
- Wilkie, George, 1983, et al.
(författare)
-
First principles of modelling the stabilization of microturbulence by fast ions
- 2018
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Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 58:8
-
Tidskriftsartikel (refereegranskat)abstract
- The observation that fast ions stabilize ion-temperature-gradient-driven microturbulence has profound implications for future fusion reactors. It is also important in optimizing the performance of present-day devices. In this work, we examine in detail the phenomenology of fast ion stabilization and present a reduced model which describes this effect. This model is derived from the high-energy limit of the gyrokinetic equation and extends the existing 'dilution' model to account for nontrivial fast ion kinetics. Our model provides a physically-transparent explanation for the observed stabilization and makes several key qualitative predictions. Firstly, that different classes of fast ions, depending on their radial density or temperature variation, have different stabilizing properties. Secondly, that zonal flows are an important ingredient in this effect precisely because the fast ion zonal response is negligible. Finally, that in the limit of highly-energetic fast ions, their response approaches that of the 'dilution' model; in particular, alpha particles are expected to have little, if any, stabilizing effect on plasma turbulence. We support these conclusions through detailed linear and nonlinear gyrokinetic simulations.
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| 13. |
- Adesiyun, Adewole, et al.
(författare)
-
Review and Evaluation of NRAs : Deliverable D2
- 2023
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Connected and Automated Driving (CAD) is an important area of digital technology that will bring disruption to individuals, economies, and societies. Most forms of CAD require some level of infrastructure support for their safe operation. Additional infrastructure and services to support CAD have the potential to improve safety even further, and to bring other benefits such as increased efficiency or reduced congestion. However, the infrastructure requirements from Original Equipment Manufacturer (OEMs) are not always clear, and it is difficult for National Road Authorities (NRAs) to predict and plan for the future levels of support needed for CAD given rapidly evolving technology and uncertain projections of future CAD demand. In addition, there is also a need for better dialogue among NRAs, OEMs and service providers to articulate those requirements and to define a roadmap and responsibilities for achieving safe and smart roads through CAD.The aim of DiREC is to establish a CAV Readiness Framework and a set of toolkits dedicated to CAVs (Connected and Autonomous Vehicles) that incorporates a wide range of components that affect CAD and the ability of highway infrastructure to support it. These components include machine readability of physical infrastructure, digital services, connectivity, in addition to aspects such as governance of the infrastructure and services, and legal and regulatory requirements. Together these components influence the ability of the NRA to become a digital road operator. The DiREC project will thus provide a framework for NRAs, service providers and OEMs to support CAD. It will consolidate and combine standards, research, and recommendations from other projects and extend research into new areas such as creating a common vision for digital twins among NRAs, understanding connectivity and connectivity requirements to support digital services and analysing how these can be met, reviewing the quality management processes around digital data, and documenting existing legal and regulatory frameworks in all areas relating to CAD.
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| 14. |
- Ahlström, Christer, et al.
(författare)
-
Validating speed and road surface realism in VTI driving simulator III
- 2012
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Nya simulatormodeller för vibrationer, ljud och grafik har utvecklats och implementerats i VTI:S fordonssimulator III. Syftet med denna studie är att validera simulatorn med avseende på hastighet och återgivandet av olika vägyteparametrar. Tjugofyra försökspersoner deltog i studien. De fick köra en och samma rutt i såväl simulator III som på verklig väg. Tre vägavsnitt med olika kvalitet på vägytan, från mycket slät till ganska ojämn, ingick i försöket. Såväl den objektiva förarparametern hastighet som olika subjektiva parametrar avseende förarens uppfattning om vägytans egenskaper (jämnhet, tysthet, komfort) jämfördes. Ett vägavsnitt med skiftande hastighetsgränser var av speciellt intresse. Ingen signifikant skillnad kunde noteras mellan körning i simulator och på verklig väg vare sig avseende hastighet (på avsitt med konstant hastighetsgräns) eller gradering av jämnhet och tysthet. För sträckan med skiftande hastighetsgränser fanns dock en signifikant skillnad mellan hastigheten i bil jämfört med hastigheten i simulator, trots liknande hastighetsprofiler. Såväl accelerationerna som retardationerna var snabbare i simulatorn. Vägkomforten graderades högre i bil än i simulator, men i båda fallen var tendensen den att slätare vägar gav högre värdering av komforten. Dessa resultat indikerar absolut validitet för graderingen av jämnhet och tysthet och för det objektiva måttet hastighet, medan relativ validitet indikerades för såväl hastighet vid skylt för hastighetsändring som för gradering av komfort.
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| 15. |
- Amnebrink, Dennis, et al.
(författare)
-
Genome-resolved analysis reveals transcriptional transitions across seasons in Baltic Sea prokaryotes
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Microbial communities in surface waters of temperate seas are exposed to recurring annual seasonal variation in temperature and nutrient concentrations. To what extent bacterioplankton populations in natural communities alter their functional repertoire as a result of seasonal succession has not been thoroughly investigated. Here we use metatranscriptomics and leverage a comprehensive catalogue of metagenome-assembled genomes (MAGs) to follow gene expression in individual populations over a two-year time period at an offshore station in the Baltic Sea. We show that the collective expression of the MAGs changed in a consistent manner across seasons in the two years, forming clusters representing the four seasons, and that more than 80% of these displayed a recurring seasonal pattern. Furthermore, we found that the changes in expression could partly be explained by modulation of expression within the prokaryotic populations, since intra-population expression patterns also changed with season. Taken together, our results demonstrate how natural microbial populations alter their expression on the gene level, and how these changes drive large scale changes on both population and community level. This work aims to broaden the understanding of how microbes respond and adapt to their environment by preferentially altering their expressed genetic repertoire, and how microbial community dynamics can be explained through the gene expression of various populations constituting the community.
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| 16. |
- Amnebrink, Dennis, et al.
(författare)
-
Seasonal dynamics and life cycle strategies of the cyanobacterium Aphanizomenon in the Baltic proper
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Aphanizomenon, together with Dolichospermum and Nodularia, constitute the major genera of bloom forming filamentous nitrogen fixing cyanobacteria in the Baltic Sea. Like the other genera, Aphanizomenon displays summer blooms that are highly variable in magnitude and duration but unlike the others it is considered a holoplanktonic species. Still, the molecular mechanisms enabling Aphanizomenon year-round presence in surface waters are currently unknown. Here we combine analysis of Aphanizomenon population dynamics at the Linnaeus Microbial Observatory (LMO) station in the Baltic Proper over nine years (2011-2019) with associated gene expression patterns during 2016-2017 to identify annual abundance, and metabolic and life cycle strategies. Aphanizomenon biomass showed large annual variability and a consistent biovolume peak in summer, with bloom intensity ranging from 78-1334 mm3 m-3. 16S rRNA gene amplicon sequence data showed that one Aphanizomenon amplicon sequence variant (ASV) dominated, and its relative abundance correlated with biovolume measurements. Metatranscriptomic reads that mapped to an Aphanizomenon metagenome- assembled genome (MAG) revealed annually repeating gene expression patterns, resulting in distinct gene expression profiles during different meteorological seasons. Genes encoding proteins involved in several important functional classes, e.g. carbon fixation, photosynthesis, and associated photopigments showed seasonal variation, but were detected year round. Other genes, particularly those involved in nitrogen fixation, were highly expressed in summer, while absent in winter. Vitamin metabolism and phosphorus scavenging genes were preferentially expressed during the colder periods of the annual cycle. Together, these data show that Aphanizomenon regulates the molecular machinery on the seasonal scale, providing context to the observed dynamics of Aphanizomenon in the Baltic Proper and a foundation for understanding the ecology of these cyanobacteria.
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| 17. |
- Andersson, Anders, 1983-, et al.
(författare)
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A Framework for Credibility Assessment of a Powertrain Model in Driving Simulator Studies
- 2016
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Ingår i: Proceedings of the 36th FISITA World Automotive Congress.
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Konferensbidrag (refereegranskat)abstract
- When performing a driving simulator study, validity of the vehicle model for the intended driving task is of key importance; otherwise, the reliability of the study results might be jeopardized. In this paper a framework for real-time credibility assessment of the simulated longitudinal dynamics by a powertrain model in a moving base driving simulator is presented. The framework consists of the physical system model and a quality model which run in parallel in real time. The developed framework has been evaluated by offline simulations, as well as in real-time in a moving base driving simulator. The evaluation results showed that the developed framework can accurately capture the validity of the powertrain model in different driving conditions and provide the credibility level of the simulation results to the simulator operator in real-time.
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| 18. |
- Andersson, Anders, 1983-, et al.
(författare)
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A Moving Base Simulator Investigation of Effects of a Yaw Stability System Caused by a Side Impact
- 2011
-
Ingår i: Journal of Computing and Information Science in Engineering. - : ASME International. - 1530-9827 .- 1944-7078. ; 11:4
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Tidskriftsartikel (refereegranskat)abstract
- The main objective of this study was to investigate how an electronic stability control (ESC) system may aid the driver in a critical sideswipe accident. Another objective was to investigate the possibility of having a realistic simulation of a sideswipe accident in a large moving base simulator. The experiment can be divided into two parts. In part one, the driver is unaware of the sudden side impact and in part two, the side impact was repeated six times.The experiment was driven by 18 persons. With the ESC system active no driver lost control, while with the system inactive there were five drivers that lost control in part one. In part two, the ESC system showed to stabilize the vehicle faster, and the improvement in stabilization time was between 40% and 62%. It was also seen that 2% loss of control occurred with an ESC system active and 45% without.
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| 19. |
- Andersson, Anders, 1983-, et al.
(författare)
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Co-simulation architecture with pedestrian, vehicle, and traffic simulators
- 2021
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Ingår i: Actes (IFSTTAR). - : Driving Simulation Association. ; , s. 181-184
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Konferensbidrag (refereegranskat)abstract
- Automated and connected traffic systems with cooperative functionality need effective testing. One way to enable such testing is to represent the current traffic environment by co-simulating different simulators using a communication layer between the simulators for cooperative functionality. With this approach, this paper presents a platform with its included simulators (vehicle, pedestrian, and traffic simulators), the used run-time infrastructure (RTI) for co-simulation, and the connection to the Unreal Engine based visual system for the simulators. The architecture was tested with two vehicle simulators (one autonomous bus and a truck), one pedestrian simulator, and one traffic simulator connected using a cloud-based service for the RTI.
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| 20. |
- Andersson, Anders, 1983-
(författare)
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Distributed Moving Base Driving Simulators : Technology, Performance, and Requirements
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Development of new functionality and smart systems for different types of vehicles is accelerating with the advent of new emerging technologies such as connected and autonomous vehicles. To ensure that these new systems and functions work as intended, flexible and credible evaluation tools are necessary. One example of this type of tool is a driving simulator, which can be used for testing new and existing vehicle concepts and driver support systems. When a driver in a driving simulator operates it in the same way as they would in actual traffic, you get a realistic evaluation of what you want to investigate. Two advantages of a driving simulator are (1.) that you can repeat the same situation several times over a short period of time, and (2.) you can study driver reactions during dangerous situations that could result in serious injuries if they occurred in the real world. An important component of a driving simulator is the vehicle model, i.e., the model that describes how the vehicle reacts to its surroundings and driver inputs. To increase the simulator realism or the computational performance, it is possible to divide the vehicle model into subsystems that run on different computers that are connected in a network. A subsystem can also be replaced with hardware using so-called hardware-in-the-loop simulation, and can then be connected to the rest of the vehicle model using a specified interface. The technique of dividing a model into smaller subsystems running on separate nodes that communicate through a network is called distributed simulation.This thesis investigates if and how a distributed simulator design might facilitate the maintenance and new development required for a driving simulator to be able to keep up with the increasing pace of vehicle development. For this purpose, three different distributed simulator solutions have been designed, built, and analyzed with the aim of constructing distributed simulators, including external hardware, where the simulation achieves the same degree of realism as with a traditional driving simulator. One of these simulator solutions has been used to create a parameterized powertrain model that can be configured to represent any of a number of different vehicles. Furthermore, the driver's driving task is combined with the powertrain model to monitor deviations. After the powertrain model was created, subsystems from a simulator solution and the powertrain model have been transferred to a Modelica environment. The goal is to create a framework for requirement testing that guarantees sufficient realism, also for a distributed driving simulation.The results show that the distributed simulators we have developed work well overall with satisfactory performance. It is important to manage the vehicle model and how it is connected to a distributed system. In the distributed driveline simulator setup, the network delays were so small that they could be ignored, i.e., they did not affect the driving experience. However, if one gradually increases the delays, a driver in the distributed simulator will change his/her behavior. The impact of communication latency on a distributed simulator also depends on the simulator application, where different usages of the simulator, i.e., different simulator studies, will have different demands. We believe that many simulator studies could be performed using a distributed setup. One issue is how modifications to the system affect the vehicle model and the desired behavior. This leads to the need for methodology for managing model requirements. In order to detect model deviations in the simulator environment, a monitoring aid has been implemented to help notify test managers when a model behaves strangely or is driven outside of its validated region. Since the availability of distributed laboratory equipment can be limited, the possibility of using Modelica (which is an equation-based and object-oriented programming language) for simulating subsystems is also examined. Implementation of the model in Modelica has also been extended with requirements management, and in this work a framework is proposed for automatically evaluating the model in a tool.
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| 21. |
- Andersson, Anders, 1983-, et al.
(författare)
-
Framtagning av loktågsmodell för VTI:s tågsimulator
- 2017
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Genom höjda hastigheter för godståg finns möjligheter till en högre prioritering av trafikslaget hos tågtrafikledningen, vilket i sig är en kapacitetsvinst och bör ge upphov till bättre flöden och högre kapacitet på det svenska järnvägsnätet (framför allt på stambanorna). Simulatorer är ett effektivt och säkert sätt att undersöka effekter av förändringar på både förarbeteende och kapacitet.Syftet med det här projektet var att skapa kapacitetshöjande möjligheter och åtgärder genom att ta fram en loktågssimulator och undersöka möjliga användningsområden för denna. Målet med projektet var att få fram en loktågssimulator, bestående av ett lok och ett antal vagnar, som kan användas i studier för att öka kapaciteten genom till exempel optimerad hastighet, och därmed förändrade bromsprofiler, för loktåg. Projektet har levererat kunskap i form av nya testmetoder, en loktågssimulator samt mjukvaruplattform för ytterligare testverksamhet.Projektet genomfördes i tre successiva etapper. I den första etappen genomfördes en förstudie med lokförare, operatörer och problemägare, som gav forskarna en förståelse för förarmiljön. Här samlades även in en del av det underlag som krävdes för utveckling av loktågsimulatorn. I den andra etappen utvecklades en simulator för loktåg (mjukvara och hårdvara). Etapp tre var en valideringsstudie tillsammans med lokförare.Ett förarbord av modellen Traxx köptes in från en tysk tillverkare. Fordonsmodellen utvecklades från en enstaka enhet, Reginamodell (motorvagnståg), till en kombination av flera enheter. Loktåget i simulatorn består av ett eller flera draglok samt ett antal vagnar med en total längd på maximalt 750 meter. Som draglok används ett lok av modellen Traxx. För varje enhet, lok och vagn, krävs data över enheten: längd, vikt, last, broms-, rull- och luftmotstånd. För lok tillkommer dessutom information om ljud, drivning, broms (återmatande elbroms samt konventionell pneumatisk broms (P-broms)), hyttutrustning med mera. För närvarande finns bansträckningen mellan Falköping–Jönköping–Forserum färdigmodellerad och kommer användas för loktågskörning med ATC. Modellen är konfigurerbar utifrån ett lok (Traxx) och i nuläget fyra olika vagnar. Dessa kan kopplas samman i olika kombinationer.Några användningsområden som diskuterades redan vid projektstart var dels de som naturligt kan kopplas till följder av längre och tyngre tåg, dels de idéer som uppkom som följd av den utrustning som köptes in. Vid Trafikverkets vintermöte genomfördes en workshop där ytterligare användningsområden diskuterades. Några av dessa handlar om utbildning,energieffektiv körning eller projektering. Utbildning och vissa typer av studier går att göra med den nu existerande loktågsmodellen, medan andra kräver antingen validering av parametrar eller viss vidareutveckling av modellen.Projektet har levererat kunskap i form av nya testmetoder, denna forskningsrapport och en produkt i form av en loktågssimulator samt mjukvaruplattform för ytterligare testverksamhet. Projektet har även levererat en nationell resurs i form av simulatormjukvara. Mjukvaran har lagt grunden för en kostnadseffektiv testverksamhet inom loktågsdomänen. En loktågssimulering (simulering av loktåg) har tagits fram, vilken kommer att vara värdefull som ett demonstrationsverktyg samt för utbildning, träning och projektering.
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| 22. |
- Andersson, Anders, 1983-, et al.
(författare)
-
Freight train model for real-time simulation
- 2017
-
Ingår i: Dynamics of Vehicles on Roads and Tracks Vol 2.
-
Konferensbidrag (refereegranskat)abstract
- In an attempt to increse the freight transport capacity in Sweden, introduction of longer and heavier trains is investigated. To aid this investigation, a freight train simulator was designed and constructed. Here, the implemented freight train dynamics model is described, which includes slip control, a modular wagon model structrue and pneumatic brake system. Further, stable real-time performance of the implemented dynamics model is discussed.
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| 23. |
- Andersson, Anders, 1983-, et al.
(författare)
-
Models for Distributed Real-Time Simulation in a Vehicle Co-Simulator Setup
- 2013
-
Ingår i: Proceedings of the 5th International Workshop on Equation-Based Object-Oriented Modeling Languages and Tools. - Linköping : Linköping University Electronic Press. - 9789175196176 - 9789175196213 ; , s. 131-139
-
Konferensbidrag (refereegranskat)abstract
- A car model in Modelica has been developed to be used in a new setup for distributed real-time simulation where a moving base car simulator is connected with a real car in a chassis dynamometer via a 500m fiber optic communication link. The new co-simulator set-up can be used in a number of configurations where hardware in the loop can be interchanged with software in the loop. The models presented in this paper are the basic blocks chosen for modeling the system in the context of a distributed real-time simulation, estimating parameters for the powertrain model, the choice of numeric solver, and the interaction with the solver for real-time properties.
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| 24. |
- Andersson, Anders, 1983-, et al.
(författare)
-
Powertrain Model Assesment for Different Driving Tasks through Requirement Verification
- 2016
-
Ingår i: Proceedings of the 9th EUROSIM Congress on Modelling and Simulation.
-
Konferensbidrag (refereegranskat)abstract
- For assessing whether a system model is a good candidate for a particular simulation scenario or choosing the best system model between multiple design alternatives it is important to be able to evaluate the suitability of the system model. In this paper we present a methodology based on finite state machine requirements verifying system behavior in a Modelica environment where the intended system model usage is within a moving base driving simulator. A use case illustrate the methodology with a Modelica powertrain system model using replaceable components and measured data from a Golf V. The achieved results show the importance of context of requirements and how users are assisted in finding system model issues.
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| 25. |
- Andersson, Anders, 1983-, et al.
(författare)
-
Vehicle model quality framework for moving base driving simulators, a powertrain model example
- 2018
-
Ingår i: International Journal of Vehicle Systems Modelling and Testing. - : InderScience Publishers. - 1745-6436 .- 1745-6444. ; 13:2, s. 93-108
-
Tidskriftsartikel (refereegranskat)abstract
- Moving base driving simulators, with an enclosed human driver, are often used to study driver-vehicle interaction or driver behaviour. Reliable results from such a driving simulator study strongly depend on the perceived realism by the driver in the performed driving task. Assuring sufficient fidelity for a vehicle dynamics model during a driving task is currently to a large degree a manual task. Focus here is to automate this process by employing a framework using collected driving data for detection of model quality for different driving tasks. Using this framework, a powertrain model credibility is predicted and assessed. Results show that chosen powertrain model is accurate enough for a driving scenario on rural roads/motorway, but need improvements for city driving. This was expected, considering the complexity of the vehicle dynamics model, and it was accurately captured by the proposed framework which includes real-time information to the simulator operator.
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| 26. |
- Andersson, Emma, 1983-, et al.
(författare)
-
Improved Railway Timetable Robustness for Reduced Traffic Delays – a MILP approach
- 2015
-
Ingår i: 6th International Conference on Railway Operations Modelling and Analysis, Tokyo, Mars 23-26, 2015..
-
Konferensbidrag (refereegranskat)abstract
- Maintaining high on-time performance and at the same time having high capacity utilization is a challenge for several railway traffic systems. The system becomes sensitive to disturbances and delays are easily propagating in the network. One way to handle this problem is to create more robust timetables; timetables that can absorb delays and prevent them from propagating. This paper presents an optimization approach to reduce the propagating of delays with a more efficient margin allocation in the timetable. A Mixed Integer Linear Programming (MILP) model is proposed in which the existing margin time is re-allocated to increase the robustness for an existing timetable. The model re-allocates both runtime margin time and headway margin time to increase the robustness at specific delay sensitive points in a timetable. We illustrate the model’s applicability for a real-world case where an initial, feasible timetable is modified to create new timetables with increased robustness. These new timetables are then evaluated and compared to the initial timetable. We evaluate how the MILP approach affects the initial timetable structure and its capability to handle disturbances by exposing the initial and the modified timetables to some minor initial disturbances of the range 1 up to 7 minutes. The results show that it is possible to reduce the delays by re-allocating margin time, for example, the total delay at end station decreases with 28 % in our real-world example.
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| 27. |
- Andersson, Emma, 1983-, et al.
(författare)
-
Increasing robustness at single-track lines using the indicator robustness in passing pointss
- 2023
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- When several trains are planned to use the same infrastructure resource, there is always a risk for spreading of delays, which can be hard to recover from. It is a challenge for the Infrastructure Manager to make timetables that accommodate as much traffic as possible, without causing bad on-time performance. Timetable planners are in need of quantitative indicators to assess timetable robustness and accurate methods for how to make the timetable more robust.In this paper we assess the robustness for single-track lines with non-periodic timetables. At single-track lines, trains use the line for running in both directions and the trains can only pass or overtake each other at passing loops. This makes the system more sensitive for delays. In this paper we present a robustness indicator which captures the dependencies between trains at a single-track line. The indicator can be used to illustrate weaknesses in a timetable and also to indicate where and how to insert more robustness. In a simulation study, we show that it is possible to improve the performance by making small timetable adjustments according the indicator, without increasing runtimes or capacity utilization.
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| 28. |
- Andersson, Emma, 1983-, et al.
(författare)
-
Introducing a New Quantitative Measure of Railway Timetable Robustness Based on Critical Points
- 2013
-
Ingår i: 5th International Seminar on Railway Operations Modelling and Analysis - RailCopenhagen 2013. - 9788773272466
-
Konferensbidrag (refereegranskat)abstract
- The growing demand for railway capacity has led to high capacity consumption at times and a delay-sensitive network with insufficient robustness. The fundamental challenge is therefore to decide how to increase the robustness. To do so there is a need for accurate measures that return whether the timetable is robust or not and indicate where improvements should be made. Previously presented measures are useful when comparing different timetable candidates with respect to robustness, but less useful to decide where and how robustness should be inserted. In this paper, we focus on points where trains enter a line, or where trains are being overtaken, since we have observed that these points are critical for the robustness. The concept of critical points can be used in the practical timetabling process to identify weaknesses in a timetable and to provide suggestions for improvements. In order to quantitatively assess how crucial a critical point may be, we have defined the measure RCP (Robustness in Critical Points). A high RCP value is preferred, and it reflects a situation at which train dispatchers will have higher prospects of handling a conflict effectively. The number of critical points, the location pattern and the RCP values constitute an absolute value for the robustness of a certain train slot, as well as of a complete timetable. The concept of critical points and RCP can be seen as a contribution to the already defined robustness measures which combined can be used as guidelines for timetable constructors.
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| 29. |
- Andersson, Emma V., 1983-, et al.
(författare)
-
Quantifying railway timetable robustness in critical points
- 2013
-
Ingår i: Journal of Rail Transport Planning and Management. - : Elsevier. - 2210-9706 .- 2210-9714. ; 3:3, s. 95-110
-
Tidskriftsartikel (refereegranskat)abstract
- Several European railway traffic networks experience high capacity consumption during large parts of the day resulting in delay-sensitive traffic system with insufficient robustness. One fundamental challenge is therefore to assess the robustness and find strategies to decrease the sensitivity to disruptions. Accurate robustness measures are needed to determine if a timetable is sufficiently robust and suggest where improvements should be made.Existing robustness measures are useful when comparing different timetables with respect to robustness. They are, however, not as useful for suggesting precisely where and how robustness should be increased. In this paper, we propose a new robustness measure that incorporates the concept of critical points. This concept can be used in the practical timetabling process to find weaknesses in a timetable and to provide suggestions for improvements. In order to quantitatively assess how crucial a critical point may be, we have defined the measure robustness in critical points (RCP). In this paper, we present results from an experimental study where a benchmark of several measures as well as RCP has been done. The results demonstrate the relevance of the concept of critical points and RCP, and how it contributes to the set of already defined robustness measures
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| 30. |
- Andersson, Jon, 1985, et al.
(författare)
-
Environmental Impact Assessment for Manufacturing: Data Requirements for a Simulation-Based Approach
- 2012
-
Ingår i: Swedish Production Symposium. - 9789175197524 ; , s. 151-160
-
Konferensbidrag (refereegranskat)abstract
- The environmental footprint of products is an increasingly important measure for companies working to improve their sustainability performance, and the same measure has also become popular for marketing purposes. As a result, the demand for environmental product declarations and, thus, life cycle assessment (LCA) projects grows. To reap the full benefit from LCA studies in production systems analysis, LCA has more frequently been complemented with simulation of production flows (i.e. discrete event simulation) during the latest decade. Several examples of the DES-LCA combination in recent literature report substantial potential and successful implementations. However, a common problem is to establish efficient and credible procedures for collecting, analyzing, and representing the extensive amounts of input data required. The aim of this paper is therefore to provide recommendations for the management of environmental data in sustainability simulations. A review of seven previous DES-LCA projects provides a list of common sustainability parameters and experiences on how they should be collected and represented in simulation models. An important result is that deterministic representations appear to be enough for data not directly linked to production time. This finding makes it possible to replace time-consuming data gathering with collection of secondary data from public databases.
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| 31. |
- Andersson, Jon, 1985, et al.
(författare)
-
Framework for Ecolabeling using Discrete Event Simulation
- 2012
-
Ingår i: Proceedings of the 2012 spring simulation multiconference.
-
Konferensbidrag (refereegranskat)abstract
- Ecolabled products have shown a competitive advantage to other products. Regulatory changes and market pressure creates an increased need for environmental impact assessments. The dominating method for environmental impact assessments - life cycle assessment (LCA) lacks support to properly analyze the dynamic aspects of business operations and production processes. This Paper proposes to use discrete event simulation to support more extensive and detailed environmental assessments on selected parts of the production process, keeping simplicity for parts of less importance and interest.
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| 32. |
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| 33. |
- Andersson White, Pär, 1983-
(författare)
-
Social Inequalities in Child Health : Type 1 Diabetes, Obesity, Cardiovascular Risk Factors and the Role of Self-control
- 2024
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Swedish Commission on Health Inequality defined health inequality as systematic differences in health between groups in society with different social positions. All avoidable socioeconomic health inequalities are unfair, and as stated by WHO's Commission on the Social Determinants of Health, we have a moral obligation to try to reduce them. "Putting these inequities right is a matter of social justice. Reducing health inequities is, for the Commission on Social Determinants of Health, an ethical imperative." This ethical imperative is especially apparent regarding the health of children and adolescents. Children’s right to the highest attainable standard of health is also enshrined in Article 24 of the Convention on the Rights of the Child. To reach the goal of a reduction of health inequalities, research is necessary to describe the social gradients of health. Research is also needed to better understand why these gradients occur. A better understanding and knowledge about health inequalities can lead to policies that reduce these inequalities and ensure children’s right to health.This thesis investigates social inequality in child health using data from a Swedish population-based prospective birth cohort, the All Babies in Southeast Sweden (ABIS) cohort. Social inequality in obesity in the ABIS cohort is also compared with other birth cohorts participating in the Elucidating Pathways to Child Health Inequality (EPOCH) collaboration which includes cohorts from six high-income countries; Sweden, the Netherlands, Canada (one national and one cohort from Quebec), UK, Australia, and USA.In Paper 1 we show that health inequalities in overweight and obesity are detectable already at two years of age and that these inequalities increase during childhood. In adolescents, low socioeconomic status increases the risk of becoming overweight and the risk of components of the metabolic syndrome, including high blood pressure and dyslipidemia (low high-density cholesterol).The level of inequality in obesity in the Swedish ABIS cohort was lower than in the other participating countries in the EPOCH collaboration (Paper 2). Inequality was lower in absolute and relative terms when SES was measured by household income. Inequality was also lower in absolute, but not relative, terms when SES was measured by maternal education. This finding indicates that some of the policies implemented in Sweden may attenuate social inequalities in obesity in children. Examples of such policies with evidence for reducing social inequality in obesity implemented in Sweden include universal preschools and free school meals.This thesis also investigates health inequalities in autoimmune disease (Paper 3). In this study, we found that low socioeconomic status increased the risk of Type 1 Diabetes but not the other autoimmune diseases investigated. Path analysis indicated that part of the increased risk in children with low SES of Type 1 Diabetes might be mediated by a higher body mass index and an elevated risk of serious life events.In the final paper, this thesis tests the hypothesis that differences in maternal and child self-control mediate social inequalities in obesity. Two measures of self-control were used; for mothers, the self-control variable was based on behaviors related to self-control (smoking during pregnancy, smoking during the child’s first year of life, breastfeeding duration, and participating in the ABIS study with biological samples). For the children, the self-control variable was based on questionnaire data on the impulsivity subscale of the Strengths and Difficulties Questionnaire (SDQ). The results showed that the two measures of self-control mediated 87.5 % of the increased risk of obesity at age 19 years in children with low maternal education and 93 % of the risk if maternal BMI was also included in the selfcontrol variable.In the discussion part of this thesis, the conclusions that can be deduced from understanding the mechanisms of social inequality in child health are discussed. A theory with a central role of self-control for health inequality predicts that social inequality will increase without interventions. In an environment with rising numbers of stimuli of the human reward system, stimuli that also have negative long-term consequences (socalled Limbic traps), child and adolescent health, in general, will decrease. Because of the mechanisms related to SES and self-control, children with low SES will be disproportionally affected. The result of this development will be increasing levels of social inequalities in child health.The discussion also includes implications for policies that may improve health and reduce inequalities. These policies should reduce the exposure of children and adolescents to harmful behaviors/limbic traps. Examples of policies that have this effect include universal preschools for all children, free healthy meals in preschools and schools, increased after-school activities for all children, and longer school days for adolescents with increased hours for physical activity, music, and art. Mobile phones and social media restrictions in schools and policies to reduce use at home should also be implemented. Finally, policies should be implemented to reduce residential and school segregation in the community.
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| 34. |
- Aramrattana, Maytheewat, et al.
(författare)
-
Testing cooperative intelligent transport systems in distributed simulators
- 2019
-
Ingår i: Transportation Research Part F. - : Elsevier Ltd. - 1369-8478 .- 1873-5517. ; 65, s. 206-216
-
Tidskriftsartikel (refereegranskat)abstract
- Simulation is often used as a technique to test and evaluate systems, as it provides a cost-efficient and safe alternative for testing and evaluation. A combination of simulators can be used to create high-fidelity and realistic test scenarios, especially when the systems-under-test are complex. An example of such complex systems is Cooperative Intelligent Transport Systems (C-ITS), which include many actors that are connected to each other via wireless communication in order to interact and cooperate. The majority of the actors in the systems are vehicles equipped with wireless communication modules, which can range from fully autonomous vehicles to manually driven vehicles. In order to test and evaluate C-ITS, this paper presents a distributed simulation framework that consists of (a) a moving base driving simulator; (b) a real-time vehicle simulator; and (c) network and traffic simulators. We present our approach for connecting and co-simulating the simulators. We report on limitation and performance that this simulation framework can achieve. Lastly, we discuss potential benefits and feasibility of using the simulation framework for testing of C-ITS.
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| 35. |
- Barendregt, Wolmet, et al.
(författare)
-
Including Children with Disabilities in the Design Process : Interaction Design with Children with Disabilities
- 2014
-
Ingår i: Workshop Proceedings of Interaction Design and Children Conference IDC´14.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This workshop aims to bring together researchers and designers to exchange experiences with (participatory) design techniques for children with disabilities that may hinder communication, such as hearing aids, autism or Down’s syndrome. More specifically, the main aim is to identify commonalities and differences in current practices and discuss how to apply and adapt participatory design techniques for the different target groups. This workshop will he held jointly with the workshop on “Values and Stances in Interaction Design with Children with Disabilities".
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| 36. |
- Barendregt, Wolmet, et al.
(författare)
-
Including Children with Disabilities in the Design Process
- 2014
-
Ingår i: Workshop Proceedings of Interaction Design and Children Conference IDC´14.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This workshop aims to bring together researchers and designers to exchange experiences with (participatory) design techniques for children with disabilities that may hinder communication, such as hearing aids, autism or Down’s syndrome. More specifically, the main aim is to identify commonalities and differences in current practices and discuss how to apply and adapt participatory design techniques for the different target groups. This workshop will he held jointly with the workshop on “Values and Stances in Interaction Design with Children with Disabilities".
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| 37. |
- Busch, Susann, et al.
(författare)
-
Cellular organization and molecular differentiation model of breast cancer-associated fibroblasts
- 2017
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Ingår i: Molecular Cancer. - : Springer Science and Business Media LLC. - 1476-4598. ; 16:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The role of cancer-associated fibroblasts (CAFs) during tumour progression is obscured by the inherently complex, heterotypic nature of fibroblast cells and behaviours in various subtypes of malignancies. Therefore, we sought to identify distinct fibroblast subpopulations at the single-cell level. Methods: Using single-cell quantitative PCR as a powerful tool to study heterogeneity and rare cell events, in a high-throughput manner a panel of gene targets are run simultaneously on transcripts isolated from single cells obtained by fluorescence-activated cell sort. Assessment of cells with stem-like characteristics was attained by anchorage-independent, anoikis-resistant culture. Results: Single-cell analysis of fibroblasts and their tumour-activated counterparts demonstrated molecularly distinct cell types defined by differential expression of characteristic mesenchymal and fibroblast activation markers. Identified subpopulations presented overlapping gene expression patterns indicating transitional molecular states during fibroblast differentiation. Using single-cell resolution data we generated a molecular differentiation model which enabled the classification of patient-derived fibroblasts, validating our modelling approach. Remarkably, a subset of fibroblasts displayed expression of pluripotency markers, which was enriched for in non-adherent conditions. Yet the ability to form single-cell derived spheres was generally reduced in CAFs and upon fibroblast activation through TGF beta 1 ligand and cancer cell-secreted factors. Hence, our data imply the existence of putative stem/progenitor cells as a physiological feature of undifferentiated fibroblasts. Conclusions: Within this comprehensive study we have identified distinct and intersecting molecular profiles defining fibroblast activation states and propose that underlying cellular heterogeneity, fibroblasts are hierarchically organized. Understanding the molecular make-up of cellular organization and differentiation routes will facilitate the discovery of more specific markers for stromal subtypes and targets for anti-stromal therapies.
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| 38. |
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| 39. |
- Dini, Hoda, 1984-, et al.
(författare)
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Optimization and validation of a dislocation density based constitutive model for as-cast Mg-9%Al-1%Zn
- 2018
-
Ingår i: Materials Science & Engineering. - : Elsevier. - 0921-5093 .- 1873-4936. ; 710, s. 17-26
-
Tidskriftsartikel (refereegranskat)abstract
- A dislocation density-based constitutive model, including effects of microstructure scale and temperature, was calibrated to predict flow stress of an as-cast AZ91D (Mg-9%Al-1%Zn) alloy. Tensile stress-strain data, for strain rates from 10-4 up to 10-1 s-1 and temperatures from room temperature up to 190 °C were used for model calibration. The used model accounts for the interaction of various microstructure features with dislocations and thereby on the plastic properties. It was shown that the Secondary Dendrite Arm Spacing (SDAS) size was appropriate as an initial characteristic microstructural scale input to the model. However, as strain increased the influence of subcells size and total dislocation density dominated the flow stress. The calibrated temperature-dependent parameters were validated through a correlation between microstructure and the physics of the deforming alloy. The model was validated by comparison with dislocation density obtained by using Electron Backscattered Diffraction (EBSD) technique.
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| 40. |
- Eltahir, Mohamed, et al.
(författare)
-
An Adaptable Antibody-Based Platform for Flexible Synthetic Peptide Delivery Built on Agonistic CD40 Antibodies
- 2022
-
Ingår i: Advanced Therapeutics. - : Wiley. - 2366-3987. ; 5:7
-
Tidskriftsartikel (refereegranskat)abstract
- The agonistic potentials of therapeutic anti-CD40 antibodies have been profiled in relation to antibody isotype and epitope specificity. Still, clinical impact relies on a well-balanced clinical efficacy versus target-mediated toxicity. As CD40-mediated immune activation must rely on a combination of stimulation of antigen-presenting cells (APCs) alongside antigen presentation, for efficient T cell priming, alternative approaches to improve the therapeutic outcome of CD40-targeting strategies should focus on providing optimal antigen presentation together with CD40 stimulation. Herein, a bispecific antibody targeting CD40 as a means to deliver cargo (i.e., synthetic peptides) into APCs through a non-covalent, high-affinity interaction between the antibody and the cargo peptide, further referred to as the Adaptable Drug Affinity Conjugate (ADAC) technology, has been developed. The ADAC platform demonstrated a target-specific CD4+ and CD8+ T cell expansion in vitro and significantly improved peptide-specific CD8+ T cell proliferation in vivo. In addition, the strategy dramatically improved the in vitro and in vivo half-life of the synthetic peptides. Future applications of ADAC involve pandemic preparedness to viral genetic drift as well as neoepitope vaccination strategies where the bispecific antibody is an off-the-shelf product, and the peptide antigen is synthesized based on next-generation sequencing data mining.
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| 41. |
- Eriksson, Lars, et al.
(författare)
-
Driver acceptance and performance with LDW and rumble strips assistance in unintentional lane departures
- 2013
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In this ViP project the focus of investigation was whether drivers more readily accept either rumble strips or an in-vehicle lane departure warning system (LDW) in unintentional lane departure situations. The results show that acceptance was high for both alternatives, but while the drivers showed more satisfaction from using the LDW, they also showed more trust in the rumble strips. Twenty-four drivers drove the VTI driving simulator SIM III in car mode with simulated rumble strips in one drive and with a simulated Volvo LDW in another drive. A forced yaw motion of the vehicle induced the unintentional lane departures. The results showed no choice in favour of the LDW or the rumble strips, but a clear preference for having a function that warns for unintentional lane departure. Several participants thought it was good to have both types of warning in parallel. Although Response completion time was shorter with the rumble strips warning, there was no difference between the warning types, neither in Time to get car back in lane nor in Lane exceedence area. Thus, there were no major overall differences between the LDW and the rumble strips as measured in the present study. The conclusion is that the drivers’ acceptance, as well as performance, was high for both the rumble strips and the LDW. The positive opinion on the need for assistance systems in unintentional lane departure when drivers are directing their visual attention away from the road is thus further strengthened.
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| 42. |
- Fagerlönn, Johan, et al.
(författare)
-
Advanced driving simulator to evaluate sound design strategies for intelligent transport systems
- 2011
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Additional sound capabilities in visually advanced simulators may offer researchers and practitioners better resources to evaluate in-vehicle auditory signals and advanced auditory displays. In the first part of the present report, the implementation of a new audio system in the Scania truck cabin for the driving simulators II and III at the Swedish National Road and Transport Research Institute (VTI) is described.The new audio software is based on the Open Audio Library (OpenAL) implementation for the Macintosh Operating System OS X. It communicates with the existing simulator software using the Open Sound Control (OSC) standard. The remaining program code is open, which offers the possibility of adapting the audio system to future demands and specific needs of partners within the competence centre ViP (Virtual Prototyping and Assessment by Simulation).Another aim of the present project was to investigate the potential of urgent alarms to raise annoyance and negatively affect drivers’ subsequent responses to unrelated, critical events on the road. While performing a simulated driving task, truck drivers received two types of warnings that were designed to differ significantly in perceived urgency. Several times in the trial an unexpected event occurred just seconds after drivers were presented with an unrelated warning, and the drivers had to brake immediately to avoid a collision. The results indicate that acoustic characteristics and semantic meaning may impact the perceived annoyance of in-vehicle warnings. Furthermore, the participants who received a high-urgency warning braked significantly harder and tended to brake later than the drivers who received a low-urgency warning.The simulator study was also used to validate the reliability of the new audio system.
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| 43. |
- Harmankaya, Necati, 1983, et al.
(författare)
-
Raloxifene and alendronate containing thin mesoporous titanium oxide films improve implant fixation to bone.
- 2013
-
Ingår i: Acta biomaterialia. - : Elsevier BV. - 1878-7568 .- 1742-7061. ; 9:6, s. 7064-73
-
Tidskriftsartikel (refereegranskat)abstract
- This study tested the hypothesis that osteoporosis drug-loaded mesoporous TiO2 implant coatings can be used to improve bone-implant integration. Two osteoporosis drugs, Alendronate (ALN) and Raloxifene (RLX), were immobilized in nanoporous oxide films prepared on Ti screws and evaluated in vivo in rat tibia. The drug release kinetics were monitored in vitro by quartz crystal microbalance with dissipation and showed sustained release of both drugs. The osteogenic response after 28days of implantation was evaluated by quantitative polymerase chain reaction (qPCR), removal torque, histomorphometry and ultrastructural interface analysis. The drug-loaded implants showed significantly improved bone fixation. In the case of RLX, stronger bone-remodelling activity was observed compared with controls and ALN-loaded implants. The ultrastructural interface analysis revealed enhanced apatite formation inside the RLX coating and increased bone density outside the ALN coating. Thus, this novel combination of a thin mesoporous TiO2 carrier matrix and appropriate drugs can be used to accelerate implant fixation in trabecular bone.
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| 44. |
- Hellsmark, Hans, 1974, et al.
(författare)
-
Teknologiska innovationssystem inom energiområdet: En praktisk vägledning till identifiering av systemsvagheter som motiverar särskilda politiska åtaganden
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna rapport är att illustrera hur ett praktiskt inriktat ramverk, tekno- logiska innovationssystem (TIS), kan användas av analytiker och beslutsfattare vid departement och myndigheter för att analysera strategiskt viktiga teknikområden ?????????????????????????????????????????????????????????????????????????????I rapporten analyseras fem TIS centrerade kring havsbaserad vindkraft, marin energi, ????????????????????????????????????????????????????????????????????????????????????? systemsvagheter som bromsar områdets vidare utveckling, vilka som kan åtgärdas av systemets aktörer och vilka som motiverar särskilda politiska åtaganden. Rapporten utgör därmed ett underlag för att formulera åtgärder för att åstadkomma ökad innova- tion, teknikspridning och industrialisering inom ovan nämnda teknikområden.Studien har även möjliggjort en jämförande analys av likheter och skillnader ???????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????????? mellan områdena – de är starka respektive svaga av olika orsaker. Detta visar att ???????????????????????????????????????????????????????????????????????Samtidigt har områdena gemensamma drag. Systemets aktörer, där även politiska ???????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????- skapsnätverk. Men de har varit sämre på att skapa tidiga nischmarknader som ger utrymme för fortsatt lärande och kostnadsreduktion. Sådana nischer kan ibland skapas av marknadens aktörer, men ofta krävs politiska styrmedel. De behövs för att investeringar i kunskapsutveckling ska kunna nyttiggöras och för att en bred industriell utveckling inom nya områden skall göras möjlig i Sverige.Vidare presenteras lärdomar kring vad en aktiv teknikpolitik innebär. Två huvud- ??????????????????????????????????????????????????????????????????????????????- hällsbygget och därför bör vara ett politikområde bland många samt att den skarpa ??????????????????????????????????????????????????????????????????????????????- ?????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????? olika faser av innovationssystemets utveckling.För att lyckas med en aktiv teknikpolitik behövs en hög grad av koordinering ??????????????????????????????????????????????????????????????????????? teknikområden så att ”rätt” typ av åtgärder kan sättas in vid ”rätt” tidpunkt av ”rätt” aktör. TIS-ramverket lyfts här fram som en metod för att skapa ett sådant underlag. Slutligen presenteras en metod för projektbedömningar som syftar till att stötta handläggare i utvärderingar av projekt inom nya teknikområden.Rapporten i sin helhet riktar sig särskilt till beslutsfattare och handläggare vid myndigheter, departement och politiker, men även andra organisationer och indi- vider med intresse av att högt ställda klimatmål ska kunna nås samtidigt som en positiv näringslivsutveckling möjliggörs.
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| 45. |
- Hjort, Mattias, 1972-, et al.
(författare)
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Smarta gator : VR-simulering av framtida stadsmiljöer
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport beskriver arbetet av arbetspaket 6 och 8 i det Vinnova-finansierade projektet Smarta gator. Utifrån arkitektoniska beskrivningar har tre olika VR-miljöer skapats – så kallade ”digitala tvillingar” av en idag existerande gatumiljö i Stockholm, samt två olika tänkbara framtida versioner av gatumiljön. Den simulerade miljön kan upplevas av fotgängare i VTI:s fotgängarsimulator, och alternativt också av bilist genom co-simulering med annan körsimulator. De två tänkbara framtidsvisionerna utvärderades från ett fotgängarperspektiv genom en workshop med 30 försökspersoner i VTI:s fotgängarsimulator i Linköping. Deltagarnas svar visar tydligt att upplevelsen av trygghet, prioritet samt trevlighet/trivsel ökade i de smarta miljöerna jämfört med den ursprungliga miljön. Läsbarheten av gaturummet upplevdes i de smarta miljöerna dock något sämre än i ursprungsmiljön. En förklaring kan vara att många känner igen ursprungsmiljön eftersom det är en relativt vanlig gatutyp – breda körfält för bil, kantstensparkering och trottoarer, medan de smarta miljöerna är uppbyggda på ett annorlunda sätt vilket kan innebära en omställning för att förstå en ”ny typ” av gata. Sammantaget visar studien på hur man kan skapa gaturum som upplevs trevligare och tryggare genom att prioritera gång- och cykeltrafik genom en större yta tillägnat gång, cykel och vistelse än för motortrafik. Även skapandet av vistelseytor och sociala funktioner längs gatan hade en positiv effekt på upplevelsen av gaturummet. Att placera träd och grönska längs gatan är utöver de ekologiska fördelarna också viktigt för trivseln och upplevelsen av gaturummet. Vi konstaterar att VR-simulering kan vara ett användbart verktyg för att på ett tidigt stadium bedöma olika designlösningar. VTI:s fotgängarsimulator har ett state-of-the-art bildsystem, men dess fria yta om 3x6 meter är för liten för att på ett smidigt sätt kunna promenera runt i stadsmiljön. Autonoma fotgängare, styrda av spelmotorn Unreal Engine, upplevdes av de flesta försökspersoner som väldigt verklighetstrogna, och de bidrog till illusionen om att vara på plats i miljön.
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| 46. |
- Holmgren, Gustav, 1983-, et al.
(författare)
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Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data
- 2018
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Ingår i: Toxicological Sciences. - : Oxford University Press (OUP). - 1096-6080 .- 1096-0929. ; 163:1, s. 182-195
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Tidskriftsartikel (refereegranskat)abstract
- Anthracyclines, such as doxorubicin, are highly efficient chemotherapeutic agents against a variety of cancers. However, anthracyclines are also among the most cardiotoxic therapeutic drugs presently on the market. Chemotherapeutic-induced cardiomyopathy is one of the leading causes of disease and mortality in cancer survivors. The exact mechanisms responsible for doxorubicin-induced cardiomyopathy are not completely known, but the fact that the cardiotoxicity is dose-dependent and that there is a variation in time-to-onset of toxicity, and gender- and age differences suggests that several mechanisms may be involved. In this study, we investigated doxorubicin-induced cardiotoxicity in human pluripotent stem cell-derived cardiomyocytes using proteomics. In addition, different sources of omics data (protein, mRNA, and microRNA) from the same experimental setup were further combined and analyzed using newly developed methods to identify differential expression in data of various origin and types. Subsequently, the results were integrated in order to generate a combined visualization of the findings. In our experimental model system, we exposed cardiomyocytes derived from human pluripotent stem cells to doxorubicin for up to 2 days, followed by a wash-out period of additionally 12 days. Besides an effect on the cell morphology and cardiomyocyte functionality, the data show a strong effect of doxorubicin on all molecular levels investigated. Differential expression patterns that show a linkage between the proteome, transcriptome, and the regulatory microRNA network, were identified. These findings help to increase the understanding of the mechanisms behind anthracycline-induced cardiotoxicity and suggest putative biomarkers for this condition.
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| 47. |
- Holmgren, Gustav, 1983-, et al.
(författare)
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MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity
- 2016
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Ingår i: Toxicology in Vitro. - : Elsevier BV. - 0887-2333 .- 1879-3177. ; 34, s. 26-34
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Tidskriftsartikel (refereegranskat)abstract
- Anthracyclines, such as doxorubicin, are well-established, highly efficient anti-neoplastic drugs used for treatment of a variety of cancers, including solid tumors, leukemia, lymphomas, and breast cancer. The successful use of doxorubicin has, however, been hampered by severe cardiotoxic side-effects. In order to prevent or reverse negative side-effects of doxorubicin, it is important to find early biomarkers of heart injury and drug-induced cardiotoxicity. The high stability under extreme conditions, presence in various body fluids, and tissue specificity, makes,microRNAs very suitable as clinical.biomarkers. The present study aimed towards evaluating the early and late effects of doxorubicin on the microRNA expression in cardiomyocytes derived from human pluripotent stem cells. We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin. Investigation of the biological relevance of the identified microRNAs revealed connections to cardiomyocyte function and cardiotoxicity, thus supporting the findings of these microRNAs as potential biomarkers for drug-induced cardiotoxicity.
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| 48. |
- Johansson, Björn, 1975, et al.
(författare)
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Evaluation and Calculation of Dynamics in Environmental Impact Assessment
- 2013
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Ingår i: IFIP Advances in Information and Communication Technology. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1868-4238 .- 1868-422X. - 9783642403514 ; 397:1, s. 135-141
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Konferensbidrag (refereegranskat)abstract
- In ten years customers will select products not only based on price and quality but also with strong regard to the product value environmental footprint, including for example the energy consumed. Customers expect transparency in the product realization process, where most products are labeled with their environmental footprint. Vigorous companies see this new product value as an opportunity to be more competitive. In order to effectively label the envi-ronmental impact of a product, it is pertinent for companies to request the envi-ronmental footprint of each component from their suppliers. Hence, companies along the product lifecycle require a tool, not only to facilitate the computing of the environmental footprint, but also help reduce/balance the environmental impact during the lifecycle of the product. This paper proposes to develop a procedure that companies will use to evaluate, improve and externally advertise their product’s environmental footprint to customers.
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| 49. |
- Karlsson, Johan, 1984, et al.
(författare)
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Ex vivo alendronate localization at the mesoporous titania implant/bone interface
- 2015
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Ingår i: Journal of materials science. Materials in medicine. - : Springer Science and Business Media LLC. - 1573-4838 .- 0957-4530. ; 26
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Tidskriftsartikel (refereegranskat)abstract
- An attractive approach in implant technology is local drug delivery, and design of efficient, safe and reliable treatments. Ourhitherto strategy has been to coat Ti implants with a thin mesoporous TiO2 film that in turnis loaded with an osteoporosis drug, such as Alendronate (ALN) that is known to suppress osteoclastic activity. This system has proven highly successful and results in excellent osseointegration. However, more detailed information about drug-release and distribution at the bone/implant interface is needed. In this study, (14)C-ALN loaded titanium implants were placed up to 8weeks into rat tibia and the spatial-temporal distribution of the drug was evaluated. Autoradiography data demonstrated a sustained release of (14)C-ALN and the releaseddrug remained bound to bone in close vicinity, within 500 micrometers,of the implants. Liquid scintillation counting experiments confirmed that the distal transport of released (14)C-ALN was extremely low. The results are favorable as they show that ALN stays for a long time in the vicinity of the implant and may therefore improve for a long time the mechanical fixation of bone anchored implants. Moreover, these findings suggest due to the low systemic spreading a minimal risk of Alendronate related systemic side effects.
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| 50. |
- Karlsson, Johan, 1984, et al.
(författare)
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Localized controlled drug delivery from mesoporous implants
- 2014
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Ingår i: Technical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014. Washington, DC, United States, 15-18 June 2014. - 9781482258271
-
Konferensbidrag (refereegranskat)abstract
- Mesoporous materials possess both a well-defined topography on the nanometer scale, and they may serve as hosts for drugs. In this work, titanium implants coated with mesoporous TiO2 thin films have been evaluated both in vitro and in vivo. Material characterization showed that, long-range ordered mesoporous TiO2, with a pore-size of 6 nm, and a narrow pore-size distribution were obtained. An in vivo study demonstrated that the films were robust enough to withstand the implantation procedure. The in vitro apatite formation experiments showed that formation of apatite was higher on the mesoporous surface compared to its nonporous counterpart. In a separate in vivo study, two osteoporosis drugs, alendronate (ALN) and raloxifene (RLX), were immobilised into the nanoporous oxide films. The in vitro drug release tests carried out showed a sustained release of both drugs. The osteogenic response after 28 days of implantation of the drug-loaded implants showed a significantly improved bone fixation.
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