| 1. |
- Andersson, Mattias K, 1979, et al.
(författare)
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Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop.
- 2010
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Ingår i: BMC cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Background: The FUS-DDIT3 fusion oncogene encodes an abnormal transcription factor that has a causative role in the development of myxoid/round-cell liposarcomas (MLS/RCLS). We have previously identified FLT1 (VEGFR1) as a candidate downstream target gene of FUS-DDIT3. The aim of this study was to investigate expression of FLT1 and its ligands in MLS cells. Methods: HT1080 human fibrosarcoma cells were transiently transfected with FUS-DDIT3-GFP variant constructs and FLT1 expression was measured by quantitative real-time PCR. In addition, FLT1, PGF, VEGFA and VEGFB expression was measured in MLS/RCLS cell lines, MLS/RCLS tumors and in normal adiopocytes. We analyzed nine cases of MLS/RCLS and one cell line xenografted in mice for FLT1 protein expression using immunohistochemistry. MLS/RCLS cell lines were also analyzed for FLT1 by immunofluorescence and western blot. MLS/RCLS cell lines were additionally treated with FLT1 tyrosine kinase inhibitors and assayed for alterations in proliferation rate. Results: FLT1 expression was dramatically increased in transfected cells stably expressing FUS-DDIT3 and present at high levels in cell lines derived from MLS. The FLT1 protein showed a strong nuclear expression in cells of MLS tissue as well as in cultured MLS cells, which was confirmed by cellular fractionation. Tissue array analysis showed a nuclear expression of the FLT1 protein also in several other tumor and normal cell types including normal adipocytes. The FLT1 ligand coding gene PGF was highly expressed in cultured MLS cells compared to normal adipocytes while the other ligand genes VEGFA and VEGFB were expressed to lower levels. A more heterogeneous expression pattern of these genes were observed in tumor samples. No changes in proliferation rate of MLS cells were detected at concentrations for which the kinase inhibitors have shown specific inhibition of FLT1. Conclusions: Our results imply that FLT1 is induced as an indirect downstream effect of FUS-DDIT3 expression in MLS. This could be a consequence of the ability of FUS-DDIT3 to hijack parts of normal adipose tissue development and reprogram primary cells to a liposarcoma-like phenotype. The findings of nuclear FLT1 protein and expression of corresponding ligands in MLS and normal tissues may have implications for tissue homeostasis and tumor development through auto- or intracrine signaling.
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| 2. |
- Schwarz, Hubert, et al.
(författare)
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Integrated continuous biomanufacturing on pilot scale for acid-sensitive monoclonal antibodies
- 2022
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Ingår i: Biotechnology and Bioengineering. - : Wiley. - 0006-3592 .- 1097-0290.
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess (ICB) designed for the production of acid-sensitive monoclonal antibodies, prone to aggregate at low pH, on pilot scale. A high cell density perfusion culture, stably maintained at 100 × 106 cells/ml, was integrated with the downstream process, consisting of a capture step with the recently developed Protein A ligand, ZCa; a solvent/detergent-based virus inactivation; and two ion-exchange chromatography steps. The use of a mild pH in the downstream process makes this ICB suitable for the purification of acid-sensitive monoclonal antibodies. Integration and automation of the downstream process were achieved using the Orbit software, and the same equipment and control system were used in initial small-scale trials and the pilot-scale downstream process. High recovery yields of around 90% and a productivity close to 1 g purified antibody/L/day were achieved, with a stable glycosylation pattern and efficient removal of impurities, such as host cell proteins and DNA. Finally, negligible levels of antibody aggregates were detected owing to the mild conditions used throughout the process. The present work paves the way for future industrial-scale integrated continuous biomanufacturing of all types of antibodies, regardless of acid stability.
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| 3. |
- Wilbe, Maria, et al.
(författare)
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DLA Class II Alleles Are Associated with Risk for Canine Symmetrical Lupoid Onychodystropy (SLO)
- 2010
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 5:8, s. e12332-
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Tidskriftsartikel (refereegranskat)abstract
- Symmetrical lupoid onychodystrophy (SLO) is an immune-mediated disease in dogs affecting the claws with a suggested autoimmune aethiology. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1, -DQA1, and -DQB1 class II loci were performed in a total of 98 SLO Gordon setter cases and 98 healthy controls. A risk haplotype (DRB1*01801/DQA1*00101/DQB1*00802) was present in 53% of cases and 34% of controls and conferred an elevated risk of developing SLO with an odds ratio (OR) of 2.1. When dogs homozygous for the risk haplotype were compared to all dogs not carrying the haplotype the OR was 5.4. However, a stronger protective haplotype (DRB1*02001/DQA1*00401/DQB1*01303, OR = 0.03, 1/OR = 33) was present in 16.8% of controls, but only in a single case (0.5%). The effect of the protective haplotype was clearly stronger than the risk haplotype, since 11.2% of the controls were heterozygous for the risk and protective haplotypes, whereas this combination was absent from cases. When the dogs with the protective haplotype were excluded, an OR of 2.5 was obtained when dogs homozygous for the risk haplotype were compared to those heterozygous for the risk haplotype, suggesting a co-dominant effect of the risk haplotype. In smaller sample sizes of the bearded collie and giant schnauzer breeds we found the same or similar haplotypes, sharing the same DQA1 allele, over-represented among the cases suggesting that the risk is associated primarily with DLA-DQ. We obtained conclusive results that DLA class II is significantly associated with risk of developing SLO in Gordon setters, thus supporting that SLO is an immune-mediated disease. Further studies of SLO in dogs may provide important insight into immune privilege of the nail apparatus and also knowledge about a number of inflammatory disorders of the nail apparatus like lichen planus, psoriasis, alopecia areata and onycholysis.
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| 4. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 5. |
- Afzal, Adeel, et al.
(författare)
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Electrochemical deposition of gold on indium zirconate (InZrOx with In/Zr atomic ratio 1.0) for high temperature automobile exhaust gas sensors
- 2015
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Ingår i: Journal of Solid State Electrochemistry. - : SPRINGER. - 1432-8488 .- 1433-0768. ; 19:9, s. 2859-2868
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Tidskriftsartikel (refereegranskat)abstract
- Automobile exhaust gas emissions are causing serious damage to urban air quality in and around major cities of the world, which demands continuous monitoring of exhaust emissions. The chief components of automobile exhaust include carbon monoxide (CO), nitrogen oxides (NOx), and hydrocarbons. Indium zirconate (InZrOx) and gold/indium zirconate (Au/InZrOx) composite nanopowders are believed to be interesting materials to detect these substances. To this end, characterization and gas sensing properties of InZrOx and Au/InZrOx composite nanopowders are discussed. InZrOx nanoparticles with In/Zr atomic ratio of 1.00 (+/- 0.05) are synthesized via pH-controlled co-precipitation of In and Zr salts in aqueous ammonia. Gold (Au) nanoparticles are subsequently deposited on InZrOx using an in situ sacrificial Au electrolysis procedure. The products are characterized by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The gas sensing performance of Au/InZrOx composite nanopowder is studied by depositing a thick powder film on interdigitated electrode structures patterned on SiC substrate to facilitate high temperature operation. The resistivity of the Au/InZrOx layer is the sensor signal, and the sensors could be operated at 500-600 A degrees C, which is a suitable temperature range for engine exhaust measurements. The control sensing measurements reveal that Au/InZrOx composite nanopowder exhibits higher response towards 2-20 % O-2 gas as compared to pristine InZrOx nanoparticles. Further studies show that when applied to exhaust gases such as CO and nitric oxide (NO), the response of Au/InZrOx sensors is significantly higher towards NO in this temperature range. Thus, sensor performance characteristics of Au/InZrOx composite nanopowder are promising in terms of their applications in automobile exhaust emission control.
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| 7. |
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| 8. |
- Alm, Anita, 1953, et al.
(författare)
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BMI status in Swedish children and young adults in relation to caries prevalence.
- 2011
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Ingår i: Swedish dental journal. - : Swedish Dental Association. - 0347-9994. ; 35:1, s. 1-8
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Tidskriftsartikel (refereegranskat)abstract
- Overweight and obesity are increasing as health problems at global level. Dental caries and obesity are both multifactorial diseases and are associated with dietary habits. The aim of the present study was to investigate the relationship between body weight status and caries prevalence in an unselected population followed from pre-school years to young adulthood. The present investigation was designed as a longitudinal analysis of the association between overweight/obesity and dental caries in one population at 3, 6, 15 and 20 years of age. The result shows that adolescents (15 years) and young adults (20 years) who are overweight/obese had a statistically significantly higher caries prevalence than normal-weight young people. At 6 years of age, the odds (OR) of having caries among obese children are 2.5 times higher than the odds for caries among six-year-old children of normal weight (p = 0.04). At 3 years of age, no association between overweight/obesity and caries was found. To conclude, overweight and obese adolescents and young adults had more caries than normal-weight individuals. The present study emphasises the need for multidisciplinary approaches to change the lifestyle factors causing both overweight/obesity and dental caries.
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| 9. |
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| 11. |
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| 14. |
- Andersson, Anita, 1961-
(författare)
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Estetik på klinik : Den estetiska kirurgins legitimerande retorik
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation deals with how esthetic surgery as a phenomenon and as a pursuit has been constructed to attain cultural legitimacy, that is, how esthetic surgery has been presented, advocated, and shaped so as to make it seem a possible, reasonable, acceptable, and meaningful practice in the contemporary culture and in people-s lives. Temporally, the study period ranges from the early 1980s to the early 2000s. During that period, esthetic surgery made its breakthrough in Sweden as a practical pursuit and as a cultural phenomenon. Cultural legitimacy is a pivotal concept in the study. It is used here to denote that a pursuit or a phenomenon - in this case esthetic surgery - has attained a status in the public discourse that makes it seem conceivable and acceptable. In this dissertation, I study how this cultural legitimacy is established through expressions in media. I analyze the work of construction that is leading to esthetic surgery reaching that position from a focus on the rhetoric of legitimization, that is, how esthetic surgery is talked about so that cultural legitimacy can be attained. It is a matter of appealing to the public so that esthetic surgery is accepted as a body modification practice, available and relevant to everyone. The work with the material showed that creating justification, appeal, and credibility plays a prominent role in this construction. The promise inherent in esthetic surgery has to be presented as realistic and realizable, while simultaneously referring to culturally anchored values and defining these as associated with esthetic surgery. In this process justification, appeal and credibility have been linked to such dominating values as freedom, health and naturalness.
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| 15. |
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| 16. |
- Andersson, Anne, 1966-, et al.
(författare)
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Long-term risk of cardiovascular disease in Hodgkin lymphoma survivors : retrospective cohort analyses and a concept for prospective intervention
- 2009
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 124:8, s. 1914-1917
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies have shown increased cardiovascular mortality as late side effects in Hodgkin lymphoma (HL) patients. This study identifies stratifying risk factors for surveillance and defines concepts for a clinical feasible and noninvasive prospective protocol for intervention of cardiovascular side effects. HL patients diagnosed between 1965 and 1995 (n = 6.946) and their first-degree relatives (FDR) were identified through the Swedish Cancer Registry and the Swedish Multigeneration Registry. For the HL and FDR cohort, in-patient care for cardiovascular disease (CVD) was registered through the Hospital Discharge Registry, Sweden. Standard incidence ratios of developing CVD for the HL cohort were calculated. A markedly increased risk for in-patient care of CVD was observed in HL patients with HL diagnosed at age 40 years or younger and with more than 10 years follow-up. In the HL survivors, a family history of congestive heart failure (CHF) and coronary artery disease (CAD) increased the risk for these diseases. The Swedish Hodgkin Intervention and Prevention study started in 2007. In the pilot feasibility study for prospective intervention (47 patients), about 25% of the cases had side effects and laboratory abnormalities. These patients were referred to a cardiologist or general practitioner. In the prospective cohort, a positive family history for CHF or CAD could be a stratifying risk factor when setting up a surveillance model. The prospective on-going study presents an intervention model that screens and treats for comorbidity factors. This article also presents an overview of the study concept.
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| 17. |
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| 18. |
- Andersson, Anton, et al.
(författare)
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Recycling of Blast Furnace Sludge to the Blast Furnace via Cold-Bonded Briquettes: Evaluation of Feasibility and Influence on Operation
- 2019
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Ingår i: ISIJ International. - : Iron and Steel Institute of Japan. - 0915-1559 .- 1347-5460. ; 59:10, s. 1786-1795
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Tidskriftsartikel (refereegranskat)abstract
- Ore-based steelmaking generates various residues including dusts, sludges, scales and slags. Recycling of these residues within the process or via other applications is essential for sustainable production of steel. In blast furnace (BF) ironmaking, the gas-cleaning equipment generally recovers the particles in the off-gas as dust and sludge. Traditionally, the dry dust is recycled via the sinter or, in the case of pellet-based BF operation, via cold-bonded briquettes and injection. As the BF sludge mainly consists of iron and carbon, this residue is of interest to recycle together with the BF dust. However, depending on how the BF is operated, these two residues are more or less the major outlet of zinc from the furnace. Thus, to limit the recycled load of zinc, both materials cannot be recycled without dezincing the sludge prior to recycling. Dezincing and recycling of the low-zinc fraction of BF sludge via sinter have been reported whereas recycling via cold-bonded briquettes has not been performed. In the present study, cold-bonded briquettes containing the low-zinc fraction of dezinced BF sludge were charged as basket samples to the LKAB Experimental Blast Furnace (EBF). The excavated basket samples from the quenched EBF suggested that additions of up to 20 wt.% of upgraded BF sludge was feasible in terms of reducibility and strength. Based on these results, BF sludge were added to cold-bonded briquettes and charged in industrial-scale trials. The trials indicated that the annual generation of BF sludge, after dezincing, could be recycled to the BF.
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| 19. |
- Andersson, Anita, 1961-
(författare)
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Sänk tempot! Stress som retorisk figur i svensk reklam
- 2005. - 1
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Ingår i: Reklam och hälsa. - Stockholm : Carlsson bokförlag. - 9172036354 - 9789172036352 ; , s. 176-196
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Författarna, akademiker verksamma vid Linköpings universitet, diskuterar här reklamen och dess koppling till hälsa, från förra sekelskiftet till i dag. Tesen att det reklamen säljer är just skönhet, hälsa och välbefinnande drivs.
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| 20. |
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| 21. |
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| 22. |
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| 23. |
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| 24. |
- Andersson, Björn, 1939, et al.
(författare)
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Att förstå naturen - från vardagsbegrepp till kemi, sex "workshops"
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rapporten behandlar hur elever förstår centrala aspekter av kemin. Först kommer tre workshops om materiens bevarande, byggnad respektive faser. Därefter tas blandning, lösning och vattnets kretslopp upp. Som avslutning kommer två workshops om ämnen respektive kemiska reaktioner.
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| 25. |
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| 26. |
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| 27. |
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| 28. |
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| 29. |
- Andersson, Björn, 1939, et al.
(författare)
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On developing content‐oriented theories taking biological evolution as an example
- 2006
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Ingår i: International Journal of Science Education. - : Informa UK Limited. - 0950-0693 .- 1464-5289. ; 28:6, s. 673-695
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Tidskriftsartikel (refereegranskat)abstract
- Both in Europe and the United States there is a growing interest in design research. One example is the design and validation of topic‐oriented teaching–learning sequences. This research may be said to have two objectives. One is to design and test “useful products”, such as teachers’ guides and study material for students, which may be put into practice in various ways. The second is to contribute to the development of educational science; for example, understanding conditions for learning of given topics under regular classroom conditions. This article concerns the latter objective and deals with the development of content‐oriented theories stating conditions that promote learning with long‐term understanding of given topics. We present one such theory, concerning evolution by natural selection, and describe the arguments and evidence that underlie the theory, which we regard as a well‐founded hypothesis. Some methodological problems associated with testing this type of theory are discussed, as well as the role of content‐oriented theories in strengthening science education research as an autonomous specialization within educational science.
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| 30. |
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| 31. |
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| 32. |
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| 33. |
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| 34. |
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| 35. |
- Andersson, Gunnar, et al.
(författare)
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Karriär, kön, familj
- 1997
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Ingår i: Ledare, makt och kön: rapport till Utredningen om fördelningen av ekonomisk makt och ekonomiska resurser mellan kvinnor och män : SOU 1997:135 (Kvinnomaktutredningen) - SOU 1997:135 (Kvinnomaktutredningen). - 9138207109
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 36. |
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| 37. |
- Andersson, Kristina, 1962-, et al.
(författare)
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Chafing borderlands: obstacles for science teaching and learning in preschool teacher education.
- 2020
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Ingår i: Cultural Studies of Science Education. - : Springer Nature. - 1871-1502 .- 1871-1510. ; 15:2, s. 433-452
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Tidskriftsartikel (refereegranskat)abstract
- This study examines preservice preschool teachers’ university science education experience.The empirical data are from a research and intervention project conducted on teacher education programs at two Swedish universities. We analyzed one of the assignments completed by 111 students within a science course as well as their conversations about the assignment at a number of seminars. We combined culture contrast and thematic analysis to examine the data. The results showed a tension between the preschool culture and the university science culture. We described this tension between the boundary lines of the two cultures as a chafing borderland. These cultures do not merge, and the defined boundaries cause chafing with each other. We discuss ways of diminishing this chafing of borderlands, potential border crossings such as caring and children as boundary objects and equalizing power imbalances.
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| 38. |
- Andersson, Kristina, et al.
(författare)
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Gender theory as a tool for analysing science teaching
- 2008
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Ingår i: Planning science instruction - from insight to learning to pedagogical practices. - Reykjavík : School of education, University of Iceland. - 9789979985174 ; , s. 168-170
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Konferensbidrag (refereegranskat)abstract
- Attempts to reform science education have to a minor extent taken into account that gender issues may have an influence on the pupils, their learning and interest. Therefore, examples of using feminist or gender theories for analyzing or planning science education are difficult to find in the literature (Nyström 2007, Sinnes 2006). The aim of this study is to examine to what extent experienced teachers apprehend the gender order within the scientific classroom and also to explore if it is possible to achieve a change in these apprehensions. In-service teachers have unprepared written down their reflections about a real classroom situation, a case, and afterwards got the task of analyzing the situation once again after reading a gender theory. The teachers’ texts have been analyzed in several steps: first, the written material was analyzed to find and form categories of relevance; second, sections were raised that pointed out if the teachers had used the gender theory and in what way they had used it; and third, a comparison was made on an individual level of the teachers’ explanations in the two different tasks. The results show that the participating teachers’ understandings about gender and society were challenged ,which is expressed in different ways in their texts. One group of teachers was able to apply the theory on the concrete classroom event, another group had a discussion on a more general level, while one teacher showed a resistance to the theory and thereby also to the task. The fact that the teachers deepen and widen their interpretation of a real classroom’s event when they get access to a gender theory indicates that this method can be applied in teacher education. The usage of cases can be an instrument to link theories to practical work.
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| 39. |
- Andersson, Kristina, 1962-, et al.
(författare)
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Gender Theory as a Tool for Analysing Science Teaching
- 2009
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Ingår i: Teaching and Teacher Education. - : Elsevier BV. - 0742-051X .- 1879-2480. ; 25:2, s. 336-343
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Tidskriftsartikel (refereegranskat)abstract
- This study examines to what extent experienced teachers are aware of gender issues in the science classroom. It also explores how an introduction to gender theory might alter this awareness. Teachers wrote their reflections about a real classroom situation. They were then asked to analyse the same situation after having read texts that discussed gender theory concepts. The fourteen teachers' understanding about gender and society were challenged. Some teachers were able to analyse the case differently by applying gender theory, others discussed the case on a more general level, while one teacher showed signs of resistance regarding gender theory.
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| 40. |
- Andersson, Kristina, 1962-, et al.
(författare)
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Genusperspektiv i naturvetenskaplig undervisning
- 2006
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Ingår i: Naturfagsdidaktikkens mange facetter. - Köpenhamn : Danmarks Paedagogiska Universitets Forlag. - 8776840875 ; , s. 95-102
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Konferensbidrag (refereegranskat)abstract
- Våren 2005 har ett skolutvecklingsprojekt initierats tillsammans med åtta verksamma lärare för att studera om en ökad genusmedvetenhet kan påverka undervisningen inom naturorienterade ämnen (NO) och teknik. Lärargruppen har tillsammans med projektansvariga diskuterat litteratur från forskning inom genusvetenskap och ämnesdidaktik vid sammanlagt sju seminarietillfällen. Lärarna uppmärksammar könsbundna attitydskillnader till naturvetenskap och teknik. En ökad insikt om flickors behov av att se helheter och förstå sammanhang har fått lärarna att tänka kring sin undervisning i NO/teknik på ett nytt sätt. Lärarna har bland annat provat att presentera samma undervisningsmoment på olika sätt i flick- respektive pojkgrupper. Träning och erfarenhet inom ett område som eleverna tidigare inte behärskar, skapar trygghet och förtrogenhet med ämnet och därigenom kan attitydskillnader överbryggas. För att bättre kunna förmedla ett intresse och engagemang till eleverna uttrycker lärarna en önskan om kompetensutveckling inom NO/teknik. I artikeln presenteras delresultat från intervjuer med fyra av de deltagande lärarna.
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| 41. |
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| 42. |
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| 44. |
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| 45. |
- Andersson, Louise, et al.
(författare)
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Med värme ihågkommen
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med detta projekt har varit att med hjälp av en intervjustudie och kunskapsgenomgång redovisahur utomhusmiljö, gemensamhetslokaler och bostäder kan utformas för att minska risken för att äldreoch personer med nedsatt funktionsförmåga blir medtagna eller dör i förtid under värmeböljor. Måletär att öka medvetenheten och intresset för anpassning av miljö och byggnader hos personer ansvarigaför samhällsplanering, bostadsbestånd, trygghets-, vård- och omsorgsboenden.Städer är normalt varmare och mindre blåsiga än det omgivande landskapet. Städernas ”varmareklimat” beror främst på den större värmelagring som kan ske i byggnader, gator, trottoarer mm,begränsat med vegetation som kan skugga och avge fukt samt aktiviteter som trafik och eldning vilketgenererar värme. Under värmeböljor ökar dödligheten mer i städer. Att leva ensam, vara sängbundenoch bo på översta våningen har visats vara riskfaktorer.Åtgärderna för att minska stadens värmeö och värmeböljornas effekter på människor brukar iblanddelas in i ”mjuka åtgärder” (information, varningssystem för värmeböljor, insatser för känsligagrupper), ”gröna åtgärder” (göra staden till en grönare miljö) och ”tekniska åtgärder” (skuggandekonstruktioner, modifiering av väggar, kylning/luftkonditionering inomhus etc.), vilka kompletterarvarandra. I vissa länder, bl. a. England, ska äldreboenden ha ett samlingsrum som kan hållas svaltäven under värmeböljor, men det är oklart vilken juridisk status som bestämmelserna har.Intervjustudien syftade till att belysa hur problemen uppfattas av personal inom äldreomsorgen iSverige. Som datainsamlingsmetod genomfördes 20 semistrukturerade intervjuer medomvårdnadspersonal i Botkyrka kommun under oktober 2011. Urvalet baserades påtillgänglighetsprincipen. Innehållsanalyser gjordes på transkriberad intervjudata och kategorier ochunderkategorier skapades utifrån återkommande teman som återfanns i texten. Slutsatserna frånstudien pekar på att de utbildnings- och informationsinsatser angående värmeböljors effekter påkänsliga grupper som riktas till personal inom äldreomsorgen borde intensifieras, samt attpersonalens kunskap om verksamheten och vårdtagarnas behov borde tas tillvara redan iplaneringsstadiet för äldreboenden.
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| 46. |
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| 47. |
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| 48. |
- Andersson, Maria, et al.
(författare)
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Delay of appropriate antibiotic treatment is associated with high mortality in patients with community-onset sepsis in a Swedish setting
- 2019
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Ingår i: European Journal of Clinical Microbiology and Infectious Diseases. - : SPRINGER. - 0934-9723 .- 1435-4373. ; 38:7, s. 1223-1234
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Tidskriftsartikel (refereegranskat)abstract
- Early appropriate antimicrobial therapy is crucial in patients with sepsis and septic shock. Studies often focus on time to first dose of appropriate antibiotics, but subsequent dosing is equally important. Our aim was to investigate the impact of fulfillment of early treatment, with focus on appropriate administration of first and second doses of antibiotics, on 28-day mortality in patients with community-onset severe sepsis and septic shock. A retrospective study on adult patients admitted to the emergency department with community-onset sepsis and septic shock was conducted 2012-2013. The criterion early appropriate antibiotic treatment was defined as administration of the first dose of adequate antibiotics within 1h, and the second dose given with less than 25% delay after the recommended dose interval. A high-risk patient was defined as a septic patient with either shock within 24h after arrival or red triage level on admittance according to the Medical Emergency Triage and Treatment System Adult. Primary endpoint was 28-day mortality. Of 90 patients, less than one in four (20/87) received early appropriate antibiotic treatment, and only one in three (15/44) of the high-risk patients. The univariate analysis showed a more than threefold higher mortality among high-risk patients not receiving early appropriate antibiotic treatment. Multivariable analysis identified early non-appropriate antibiotic treatment as an independent predictor of mortality with an odds ratio for mortality of 10.4. Despite that the importance of early antibiotic treatment has been established for decades, adherence to this principle was very poor.
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| 49. |
- Andersson, Mike, 1977-, et al.
(författare)
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Detecting non-hydrogen containing species with field effect devices
- 2008
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Ingår i: IEEE Sensors,2008. - : IEEE. - 9781424425815 - 9781424425808 ; , s. 1320-1323
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Konferensbidrag (refereegranskat)abstract
- An investigation of the influence and role of oxygen in the detection of non-hydrogen containing substances with Pt/SiO2/SiC based MOS field effect sensors, employing new model systems, has been carried out. With the use of a novel intermediate layer, by which the direct influence of hydrogen on the sensor response can be markedly reduced, the part of the sensor response which is not directly related to hydrogen (which to a small extent is always present in any gas mixture) could be resolved. The Pt/SiO2 NO reduction/oxidation model system has also been studied from a sensor perspective and the results compared to spectroscopic and mass spectrometry studies of the surface reactions from the field of catalysis. The results support the hypothesis from earlier work that the removal of oxygen from the sensor surface (e.g. by oxidation reactions with CO or NO) to a certain extent directly is involved in the detection of non-hydrogen containing species.
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| 50. |
- Andersson, Mike, et al.
(författare)
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Development of a ChemFET sensor with molecular films of porphyrins as sensitive layer
- 2001
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Ingår i: Sensors and actuators. B, Chemical. - 0925-4005 .- 1873-3077. ; 77:1-2, s. 567-571
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Tidskriftsartikel (refereegranskat)abstract
- The interaction of chemical species with molecular films of porphyrins causes variations of the work function of the film itself, as it has been recently demonstrated by using the Kelvin probe technique. This characteristic makes porphyrins films suitable to be used as sensitive layers in ChemFET sensors. In this paper, we present a preliminary report about the fabrication and testing of such gas sensitive devices. The technological solutions towards an optimised device are also illustrated and discussed. © 2001 Elsevier Science B.V.
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