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1.	Sjöberg, Karin, et al. (författare) Nationell Miljöövervakning - Luft : Data tom 2011 2013 Rapport (övrigt vetenskapligt/konstnärligt)
2.	Agélii Genlott, Annika, 1968- (författare) Designing for Transformational Change in School : Digitalizing the Digitized 2020 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Digital technologies have gained a prominent role in education and schools, but research concerning how digital technologies can create better conditions for improved teaching and enhanced learning for students is scarce and inconclusive. Successful use of digital technologies requires a complex combination of interacting factors, including integrating technology and pedagogy as well as organizing and leading a structured transformation process. The capability of school organizations to lead and support the digitalization process is an under-researched field compared to the well-established focus on individual stakeholders.This thesis examines how experimentation and innovation processes in school can be designed and pursued to support and enhance digitalization across an entire school organization by using a Design Science Research (DSR) approach to answer the question: How can a school organization at municipal level lead digital transformation through the digitalization of teaching and learning processes in an organized, professional, and, as far as possible, scientifically based way?The findings show that the design and use of the Information System Artifact model (ISA) together with a DSR development method can support both improved teaching and enhanced learning within and across a school organization. Effective use of digital technologies to improve teaching and learning across the school organization requires fundamental changes of ordinary practices and engagement as well as commitment from school authorities and school leaders.This thesis contributes with empirically and theoretically based insights from leading (digital) transformational change in school through the iterative design of IS artifacts used as a driver and quality control for the shift from digitization towards digitalization aiming at improved teaching and enhanced learning.
3.	Agélii Genlott, Annika, 1968-, et al. (författare) Leading dissemination of digital, science-based innovation in school–a case study 2021 Ingår i: Interactive Learning Environments. - : Informa UK Limited. - 1049-4820 .- 1744-5191. ; , s. 1-11 Tidskriftsartikel (refereegranskat)abstract Digitalizing school is a process that comes with challenges. It requires strategic leadership and transformational change to work processes. Nevertheless, some succeed, and it is useful to understand what makes for success. This paper studies the challenges of leading digitalization of education in a city which decided to implement an IT-supported method for teaching literacy in primary schools. The method required transformational change; teachers not only had to learn to use technologies, they also had to review their pedagogy. This study is guided by the Diffusion of Innovation theory and draws on interviews with school principals. We find that the critical factors relate to the communication channel, the social system within and across schools, and the time perspective.
4.	Andersson, Annika, et al. (författare) A field study of frazil ice accumulation and adhesion on trash racks 1992 Rapport (övrigt vetenskapligt/konstnärligt)abstract A field experiment to study frazil ice blockage of water intake trash racks in hydropower plants is described. The experiment, conducted during the 1990/1991 winter using a submerged video camera, was designed to investigate ice accumulation on trash racks and compare this with laboratory tests. Differences between ice accumulation and adhesion on steel bars with and without a rubber coating were examined. The submerged video camera functioned well and was found to be an excellent tool to document and evaluate these ice phenomena. Frazil ice problems occured in air temperatures as high as -4°C. Frazil ice accumulation started on the upper section of the trash racks and progressed downwards. Ice was mainly deposited on the upstream face of the racks. The rubber coating material, with its poor adhesion to ice, appeared to mitigate frazil ice problems in the intakes in two ways. Ice was much more easily removed from trash rack elements coated with rubber and frazil did not stick to coated trash racks under small depress of supercoolings.
5.	Andersson, Annika, et al. (författare) A study of some elemental distributions between slag and hot metal during tapping of the blast furnace 2004 Ingår i: Steel research. - : Wiley. - 0177-4832 .- 1611-3683. ; 75:5, s. 294-301 Tidskriftsartikel (refereegranskat)abstract This paper investigates the distribution of elements between slag and hot metal from a blast furnace through calculation of distribution coefficients from actual production data. First, samples of slag and hot metal tapped from a commercial blast furnace were taken continually at 10-minute intervals for a production period of 68 hours. Distribution coefficients of manganese, silicon, sulphur and vanadium were then calculated from the results of the sample analyses. A major conclusion drawn from examination of the results was that the behaviour of the studied elements was as could be expected when approaching the equilibrium reactions from thermodynamic theory. The distributions of the elements in the slag-metal system showed clear tendencies which did not appear to be influenced by the operational conditions of the furnace. For example, for manganese, vanadium and sulphur, it was found that a higher basicity led to a decreased distribution coefficient L-Mn and L-V, but an increased L-S, which is according to theory. Another observed relationship was that slag basicity increased with an increased carbon content in the hot metal, which indicated that SiO2 was reduced to [Si] when the oxygen potential decreased. Furthermore, it was found that sulphur and silica behaviour likened that of acidic slag components, while the manganese oxide and vanadium oxide behaviour was similar to that of basic slag components.
6.	Andersson, Annika J., et al. (författare) Variation in hot metal and stag composition during tapping of blast furnace 2004 Ingår i: Ironmaking & steelmaking. - : Informa UK Limited. - 0301-9233 .- 1743-2812. ; 31:3, s. 216-226 Tidskriftsartikel (refereegranskat)abstract To determine the quality of the hot metal and the thermal conditions inside the blast furnace, the composition of the hot metal and slag must be known. Obtaining representative metal and slag samples during tapping is thus highly important to blast furnace operation. The study covered in the present report focused on hot metal and slag composition variation during tapping from a commercial blast furnace. From the results, optimal sampling time points for obtaining elemental concentrations that can be taken as representative for the whole tapping sequence were identified. It was furthermore concluded, that the reliability of hot metal composition data is significantly improved by averaging elemental concentrations determined from two samples, each taken at a particular time point. One sampling, however, was found to be adequate for slag. Results from the study also showed a fairly strong correlation between amounts of silicon and carbon, sulphur and carbon, and silicon and sulphur in the hot metal, while a weaker correlation between hot metal temperature and each of these elements was observed.
7.	Andersson, Annika, 1981, et al. (författare) Participation in leisure activities and binge drinking in adults – findings from a Swedish general population sample. 2012 Ingår i: Addiction Research & Theory. - : Informa UK Limited. - 1606-6359 .- 1476-7392. ; 20:2, s. 172-182 Tidskriftsartikel (refereegranskat)abstract The aim of this cross-sectional study was to estimate the associations between participation in different leisure activities and binge drinking in Swedish adults. The study was based on a questionnaire in a general population sample (n=3567) of individuals aged 19–64 years old. Men and women were defined as binge drinkers if they reported that they had consumed alcohol at least once a month, and stated that at a typical drinking occasion they consumed five or more standard glasses (12g of alcohol). Multivariate analyses found associations between binge drinking and socializing with friends among men aged 19–30 years (odds ratio, OR 2.88), in the 31–64 years old age group (OR 1.87). Corresponding results was found in younger women (OR 2.36). A higher OR was also found for younger men who regularly attended sporting events as spectators (OR 1.83), and among respondents in the older age group who regularly played computer or video games (OR 2.11 for women and 1.61 for men). A lower OR for binge drinking was found for men who regularly participated in religious services in both age-groups. Lower prevalence of binge drinking among women was only found in the younger group among those who regularly participated in sports/athletics or other training (OR 0.51). Our findings suggest that prevention strategies could benefit from an everyday life approach, but also that different interventions should be used in relation to specific leisure activities.
8.	Andersson, Cecilia K, et al. (författare) Activated MCTC mast cells infiltrate diseased lung areas in cystic fibrosis and idiopathic pulmonary fibrosis 2011 Ingår i: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921 .- 1465-993X. ; 12:139 Tidskriftsartikel (refereegranskat)abstract Background: Although mast cells are regarded as important regulators of inflammation and tissue remodelling, their role in cystic fibrosis (CF) and idiopathic pulmonary fibrosis (IPF) has remained less studied. This study investigates the densities and phenotypes of mast cell populations in multiple lung compartments from patients with CF, IPF and never smoking controls. Methods: Small airways, pulmonary vessels, and lung parenchyma were subjected to detailed immunohistochemical analyses using lungs from patients with CF (20 lung regions; 5 patients), IPF (21 regions; 7 patients) and controls (16 regions; 8 subjects). In each compartment the densities and distribution of MCT and MCTC mast cell populations were studied as well as the mast cell expression of IL-6 and TGF-beta. Results: In the alveolar parenchyma in lungs from patients with CF, MCTC numbers increased in areas showing cellular inflammation or fibrosis compared to controls. Apart from an altered balance between MCTC and MCT cells, mast cell in CF lungs showed elevated expression of IL-6. In CF, a decrease in total mast cell numbers was observed in small airways and pulmonary vessels. In patients with IPF, a significantly elevated MCTC density was present in fibrotic areas of the alveolar parenchyma with increased mast cell expression of TGF-beta. The total mast cell density was unchanged in small airways and decreased in pulmonary vessels in IPF. Both the density, as well as the percentage, of MCTC correlated positively with the degree of fibrosis. The increased density of MCTC, as well as MCTC expression of TGF-beta, correlated negatively with patient lung function. Conclusions: The present study reveals that altered mast cell populations, with increased numbers of MCTC in diseased alveolar parenchyma, represents a significant component of the histopathology in CF and IPF. The mast cell alterations correlated to the degree of tissue remodelling and to lung function parameters. Further investigations of mast cells in these diseases may open for new therapeutic strategies.
9.	Andersson Höök, Lars, et al. (creator_code:cre_t) Vältalighetens dubbla ansikte : Två svenska 1600-talsorationer om talekonstens politiska användning: Text – kontext – intertext. Inledning Nils Ekedahl. Textinledning, utgåva och översättning Annika Ström 2023. - 1 Bok (refereegranskat)abstract Här presenteras två latinska orationer, hållna i Uppsala 1654. I centrum för dem står retorikens användbarhet som politiskt redskap. Tillsammans skildrar de en talekonst med dubbelt ansikte: medan den ena orationen utmålar retoriken som en försåtlig manipulationskonst framställer den andra den som fundamentet för varje civiliserat samhälle. Var retoriken ond eller god? Något entydigt svar ger inte orationerna.Vad som gör orationerna märkliga är att de kan läsas som inlägg i den politiska strid som i det fördolda rasade just vid denna tid, nämligen den nye svenske kungen Karl X Gustavs planer på att starta krig mot Polen. Samtidigt som orationerna demonstrerar renässansens syn på retoriken som politiskt verktyg ger de oväntade inblickar i tidens politiska opinionsbildning.
10.	Andersson, Kin, 1960- (författare) Proactivity at work 2015 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Proactive behaviour implies taking initiative and mastering unexpected situations, and hence, is desirable in different situations. The present thesis includes three empirical studies intended to understand the consequences of proactive behaviour, as well as the factors that contribute to proactive behaviour at work and when facing unemployment. More specifically, whether job design, as measured by objective work task analysis, provides conditions conducive to proactivity in the workplace and when facing unemployment. The results of proactive behaviour during unemployment were also of interest. Study I focused on the influence of job design on individuals’ personal initiative and confidence in their ability when facing unemployment. Participants were employees at a downsizing Swedish assembly plant. Confidence in one’s ability mediated the relationship between job design and personal initiative, and personal initiative affected job search behaviour when advised to be dismissed. Study II, a longitudinal exploration, focused on the predictors of re-employment in the same group as in Study I. Men were more than nine times as likely as women to obtain jobs within 15 months. Individuals without children were more than seven times as likely as those with children to find work within 15 months. The desire to change occupation and willingness to relocate also increased the probability of being re-employed, whereas anonymous-passive job-search behaviour and work-related self-efficacy actually decreased the probability of re-employment. The number of job applications did not impact later re-employment. Study III analysed job design as a predictor of group initiative and self-organisational activities in semiautonomous industrial work groups. An input-process-output model showed that group processes such as reflexivity mediated the impact of job design on proactivity in work groups. Taken together, these studies suggest that work task analysis a useful tool, since it provides access to information that cannot be obtained with self-report measures. Job design indirectly affected proactivity both in the face of unemployment, and in industrial work groups. Further, it is worthwhile to continue identifying the antecedents and consequences of proactivity, as this seems to be an important factor regarding work and unemployment.
11.	Bager, Johan-Emil, et al. (författare) Long-term risk-factor control and secondary prevention are insufficient after first TIA: Results from QregPV. 2023 Ingår i: European stroke journal. - 2396-9873 .- 2396-9881. ; 9:1, s. 154-161 Tidskriftsartikel (refereegranskat)abstract Long-term risk-factor control and secondary prevention are not well characterized in patients with a first transient ischemic attack (TIA). With baseline levels as reference, we compared primary-care data on blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), smoking, and use of antihypertensives, statins and antiplatelet treatment/oral anticoagulation (APT/OAC) during 5years after a first TIA.Patients in QregPV, a Swedish primary-care register for the Region of Västra Götaland, with a first TIA discharge diagnosis from wards proficient in stroke care 2010 to 2012 were identified and followed up to 5years. BP, LDL-C, smoking, use of antihypertensives, statins, APT/OAC, and achievement of target levels were calculated. We used logistic mixed-effect models to analyze the effect of follow-up over time on risk-factor control and secondary prevention treatment.We identified 942 patients without prior cerebrovascular disease who had a first TIA. Compared to baseline, the first year of follow-up was associated with improvements in concomitant attainment of BP <140/90mmHg, LDL-C<2.6mmol/L and non-smoking, which rose from 20% to 33% (OR 2.08, 95% CI 1.38-3.13), but then stagnated in years 2-5. In the first year of follow-up, 47% of patients had complete secondary prevention treatment (antihypertensives, APT/OAC and statin), but continued follow-up was associated with a yearly decrease in secondary prevention treatment (OR 0.94, 95% CI 0.94-0.98).Risk-factor control was inadequate, leaving considerable potential for improved secondary prevention treatment after a first TIA in Swedish patients followed up to 5years.
12.	Bengtsson, Stefan, et al. (författare) Mind the gap! Moving from awareness to action : Showcasing emergent research from the Swedish Graduate School in Education for Sustainable Development (GRESD) 2015 Ingår i: Abstract list of WEEC 2015. - : WEEC. Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract Introduction: The main purpose of the symposium is to showcase some recent research findings produced by PhD students accepted by or affiliated with the Swedish Graduate School in Education for Sustainable development (GRESD). Objectives: GRESD started as a state sponsored one-time research capacity development project that accepted 9 post-graduate student and included additional 9 post-graduate students all focusing on ESD in their PhD projects. With the project coming to an end and having produced a number of dissertations targeting an international research audience, it is the intention to showcase some of the central contributions made and to receive feedback on from practitioners and researchers on how existent research projects can tie into and contribute to existent demands in environmental education (EE) practice and practice. The presentations of research results are aimed to cover a wide range of issues, including topics such as evaluation of classroom practices, students qualifications, globalization and teachers’ ethical reflections the role of place-specific artifacts in learning. As GRESD is a collaboration between eight universities with their specific traditions and approaches to educational research, approaches show a creative variety of theoretical backgrounds. This variation is also reflected in the presentations that are putting into play Lacanian psychoanalysis, discourse theory, pragmatist theory and phenomenography in order to shed new light on critical areas of environmental education. Methods: The symposium will consist of an introduction (10 minutes) brief presentations (10-15 minutes each) of central research findings in the context of their overarching research projects, followed by a synthesis and suggestions by a selected commentator (20 minutes) and general discussions with the audience (20 minutes). The dialogue following the presentations is intended to outline possible future research projects as well as emerging areas topics in the portrayed GRESD research that could feed into existing demands in EE practice and research.
13.	Bergviken Rensfeldt, Annika, 1969, et al. (författare) A “situated ethics” for researching teacher professionals’ emerging Facebook group discussions 2019 Ingår i: Designs for Experimentation and Inquiry: Approaching Learning and Knowing in Digital Transformation. Åsa Mäkitalo, Todd E. Nicewonger, Mark Elam (red.). - New York : Routledge. - 9781138592711 ; , s. 197-214 Bokkapitel (refereegranskat)
14.	Bergviken Rensfeldt, Annika, 1969, et al. (författare) Powers forming the digitized teacher subjectivity: Self-technologies and algorithmic powers 2016 Ingår i: Foucault at 90, University of West Scotland, Ayr campus. June 22-23 2016, Scotland.. Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract This paper explores how social media sites, exemplified by activities within a large Facebook group of teachers with an interest in IT in the classroom, are part of forming a certain desirable teacher subjectivity, which can be defined as digitally present, competent and networking. Rather than presupposing or idealising social media activities, we are interested in how the teacher subjectivity is shaped by both social and technological powers. Empirically, we draw on material produced by collecting the interactions within a Facebook group with over 13,000 members between 2012 and 2015. This group is focused on ‘flipped classrooms,’ often described as a grass-roots movement of teachers interested in changing classroom practice by engaging students in pre-class activities through social media, user-generated content and online educational resources. This ‘movement’ is thereby heavily imbued with how social media operates and the ideals of a digitally competent, networked and self-managing teacher subjectivity. Our aim is to theorize and problematize the subjectivity formed in and by social media activities in the group. In particular, we want to address algorithmic powers (Beer, 2009), i.e. various filtering and sorting computational actions that shape what subjects encounters online. These actions are dependent on the data input of subjects, who thereby produce their own algorithmic profile. With this approach, we stress the user’s function as provider of profiled marketable data rather than solely as content provider (van Dijck, 2009). The questions raised concern how subjects conduct themselves and how social media surveillance mechanisms like algorithmic profiling co-constitute the subjectivity? We examine three distinct but intertwined aspects of how the Facebook group activities give shape to the subjectivity we call the ‘digitized teacher.’ Firstly, ways technologies of the self (Foucault, 1988) operate as teacher subjects are modifying and operating upon ‘digital selves’ by posting, commenting and liking. Secondly, ways Facebook algorithms individually curate and profile feeds and content based on algorithmic surveillance of user behaviour and input data within and outside the group. Lastly, we problematize how we as researchers co-produce social media surveillance and the subjectivity formation of the digitized teacher based on the methodology used. Beyond adding to educational research on emerging practices of liberal self-conducted powers shaping the digitized teacher subjectivity, the main contribution of this paper is to address questions of how self-powers are fuelled by surveillance powers, for example, as the notion of algorithmic powers seem to become incorporated in subjects’ own conduct of themselves. References Beer, D. (2009). Power through the algorithm? Participatory web cultures and the technological unconscious. New Media & Society 11(6), 985–1002. Foucault, M. (1988). Technologies of the self. In: L. H. Martin, H. Gutman and P. H. Hutton (Eds.). Technologies of the self. (pp. 16–49). Amherst: University of Massachusetts Press. Van Dijck, J. (2009). Users like you? Theorizing agency in user-generated content. Media, Culture & Society, 31(1), 41–58.
15.	Bergviken Rensfeldt, Annika, 1969, et al. (författare) The ‘politics of sharing’ in a large teacher professional Facebook group: Links, topics and discourses entangled with policy 2016 Ingår i: Internet, policy and politics 2016, Theme “The platform Society” 22-23 Sept, 2016, University of Oxford, UK.. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
16.	Boss, Annika, et al. (författare) Ämnen som hindrar eller försvårar återvinning av plast i prioriterade produktgrupper inom byggsektorn 2023 Rapport (övrigt vetenskapligt/konstnärligt)abstract I detta uppdrag undersöker vi kemiska tillsatser i plaster som försvårar eller utgör hinder för återvinning av materialet. I denna rapport avser kemiska tillsatser additiv som medvetet introducerats i produkten eller materialet, och det är dessa kemiska ämnens natur som avgör problematiken ur återvinningssynpunkt. Vi fokuserar på byggsektorn eftersom denna sektor använder stora mängder plast av hög kvalité. Trots detta är återvinningsgraden för plast låg och potentialen att öka återvinningsgraden är därmed stor. Ett materials potential för återvinning bestäms av flera faktorer, varav kemikalieinnehåll är en. Det är viktigt att tänka på vilken eller vilka produkter plasten är lämplig att återvinnas till, och hänsyn måste alltid tas till gällande kemikalielagstiftning för just de produkttyperna. Kemiska ämnen som kan vara skadliga för människan och/eller miljön är särskilt viktiga att utreda, men det finns också andra tillsatser i material och produkter som försvårar återvinningsprocessen eller påverkar kvalitén på den återvunna plasten negativt så att marknaden för det återvunna materialet blir begränsad. Ytterligare en faktor att ta i beaktande är hur exponeringen för kemikalierna ser ut, om de är bundna i plasten eller kan emitteras och utsätta människor och miljön för direkta risker. De stora kategorierna i denna kartläggning har varit golv, rör och rördelar, kablar, profiler och lister, isoleringsmaterial, samt tätningsskikt. För dessa produktgrupper dominerar polymertyperna PVC, PE av olika densitetsgrad och comonomer-innehåll, PP (homo- och copolymer), PS och PUR. Då härdplaster, där även PUR ingår, förekommer i form av lacker, adhesiv och ytbeläggningar i byggprodukter behandlas dessa också övergripande. Många materialströmmar finns tillgängliga för återvinning inom kategorin byggplast generellt sett, men möjligheterna och incitamenten att sortera ut dessa i sina ursprungliga fraktioner är låg. Detta beror antingen på att efterfrågan på mekaniskt återvunnet material i dessa produktkategorier inte är stor nog, som för PEX och vissa typer av rör, eller på att volymerna är för låga för lönsamhet. Ett exempel på det sistnämnda är profiler och lister av PVC där etablerad cirkulär återvinning finns ute i Europa, men produktkategorin är för liten i Sverige för att drivkraften ska uppstå. Eftersom flera av de polymermaterial och produkter vi kartlagt i denna rapport har en historisk användning av idag reglerade, eller till och med förbjudna kemiska ämnen, kompliceras återvinningen av byggplast i att de inkommande avfallsströmmarna är av mycket varierande ålder. För att möjliggöra en högre återvinningsgrad och bättre kvalitet krävs därför utökad och mer noggrann sortering så att problematiska, och i vissa fall hälso- och miljöfarliga, innehållsämnen inte följer med i den mekaniska återvinningen, men inte heller så att kvalitativa fraktioner av en viss produkt- och polymertyp avvisas från återvinning av säkerhetsskäl. Ett axplock av problematiska tillsatser är tungmetallstabilisatorer och mjukgörare i produkter av PVC, flamskyddsmedel i isolering av EPS och XPS, samt silanförnätad PEX som innehåller tennkatalysator. Kontaminering i form av härdplastrester, felsorterad PEX i PE-recyklat, samt tejper och fogar på tätskikt utgör de mer oavsiktliga, fysiska hindren för kvalitetsmässig återvinning tillsammans med faktumet att en stor del av kablar och rör helt enkelt inte utvinns ur marken efter sin användningstid. Sammanfattningsvis skulle fler fraktioner av byggplast kunna återvinnas mekaniskt genom att stärka infrastrukturen kring insamling och sortering, men för detta krävs ökad efterfrågan och långsiktig lönsamhet. Kemiska återvinningsmetoder seglar upp som en möjlig lösning för flera av de hinder som identifieras i denna studie, till exempel tvärbundna material, material med hög andel fyllmedel, eller för avskiljning av oönskade tillsatser likt tungmetaller och ftalater. Kartläggningen av detta område får därför ses som en intressant frågeställning för ytterligare arbete.
17.	Brandhorst, Heide, 1962-, et al. (författare) A new oxygen carrier for improved long-term storage of human pancreata before islet isolation 2010 Ingår i: Transplantation. - 0041-1337 .- 1534-6080. ; 89:2, s. 155-60 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Pancreas oxygenation during cold storage has been established in islet isolation and transplantation to prevent ischemic tissue damage using perfluorodecalin (PFD) as hyperoxygen carrier. However, studies in humans and pigs provided conflicting results about the efficiency of PFD for pancreas oxygenation. The aim of this study was to compare PFD with a newly developed oxygen carrier composed of perfluorohexyloctane and polydimethylsiloxane 5 (F6H8S5) for long-term storage of human pancreata.METHODS: After 24-hr storage in preoxygenated PFD or F6H8S5, pancreata were processed using Liberase HI for pancreas dissociation and a Ficoll gradient for islet purification. Islet quality assessment was performed measuring glucose-stimulated insulin release, viability, islet ATP content, and posttransplant function in diabetic nude mice.RESULTS: Compared with PFD, F6H8S5 significantly increased the intrapancreatic partial oxygen pressure and islet ATP content. This corresponded to an increase of islet yield, recovery after culture, glucose stimulation index, viability, and improved graft function in diabetic nude mice.CONCLUSIONS: The present findings indicate clearly that F6H8S5 improves isolation outcome after prolonged ischemia compared with PFD. This observation seems to be related to the significant lipophilicity and almost pancreas-specific density of F6H8S5. Moreover, these characteristics facilitate pancreas shipment without using custom-made transport vessels as required for PFD.
18.	Brandhorst, Heide, 1962-, et al. (författare) The effect of truncated collagenase class I isomers on human islet isolation outcome. 2010 Ingår i: Transplantation. - : LIPPINCOTT WILLIAMS & WILKINS. - 1534-6080 .- 0041-1337. ; 90:3, s. 334-5 Tidskriftsartikel (refereegranskat)
19.	Fredricsson, Malin, et al. (författare) Nationell luftövervakning – Sakrapport med data från övervakning inom Programområde Luft t.o.m. 2017 2018 Rapport (övrigt vetenskapligt/konstnärligt)abstract Naturvårdsverket, Luftenheten, ansvarar för den nationella luftövervakningen i bakgrundsmiljö i Sverige. I rapporten redovisas resultat från verksamheten inom Programområde Luft avseende mätningar (genomförda av IVL, SU, SLU och SMHI) till och med 2017 och regionala modellberäkningar (utförda av SMHI) till och med 2016.För flertalet av de luftföroreningskomponenter som övervakas inom den nationella miljöövervakningen har det, sedan mätningarna startade för mellan 15 och 35 år sedan, generellt sett skett en avsevärd förbättring avseende såväl halter i luft som deposition i bakgrundsmiljö. Utvecklingen har dock varierat i något olika utsträckning beroende på komponenter och lokalisering i landet. Föroreningsbelastningen är oftast lägre ju längre norrut i landet man kommer.För de flesta ämnen som det finns miljökvalitetsnormer (MKN) respektive miljömål för ligger halterna i regional bakgrund avsevärt lägre än angivna gräns- och målvärden. Halterna av ozon överskrider dock i dagsläget MKN för hälsa.
20.	Ghosheh, Nidal, 1975-, et al. (författare) Human Pluripotent Stem Cell-Derived Hepatocytes Show Higher Transcriptional Correlation with Adult Liver Tissue than with Fetal Liver Tissue 2020 Ingår i: ACS Omega. - : American Chemical Society (ACS). - 2470-1343. ; 5:10, s. 4816-4827 Tidskriftsartikel (refereegranskat)abstract Human pluripotent stem cell-derived hepatocytes (hPSC-HEP) display many properties of mature hepatocytes, including expression of important genes of the drug metabolizing machinery, glycogen storage, and production of multiple serum proteins. To this date, hPSC-HEP do not, however, fully recapitulate the complete functionality of in vivo mature hepatocytes. In this study, we applied versatile bioinformatic algorithms, including functional annotation and pathway enrichment analyses, transcription factor binding-site enrichment, and similarity and correlation analyses, to datasets collected from different stages during hPSC-HEP differentiation and compared these to developmental stages and tissues from fetal and adult human liver. Our results demonstrate a high level of similarity between the in vitro differentiation of hPSC-HEP and in vivo hepatogenesis. Importantly, the transcriptional correlation of hPSC-HEP with adult liver (AL) tissues was higher than with fetal liver (FL) tissues (0.83 and 0.70, respectively). Functional data revealed mature features of hPSC-HEP including cytochrome P450 enzymes activities and albumin secretion. Moreover, hPSC-HEP showed expression of many genes involved in drug absorption, distribution, metabolism, and excretion. Despite the high similarities observed, we identified differences of specific pathways and regulatory players by analyzing the gene expression between hPSC-HEP and AL. These findings will aid future intervention and improvement of in vitro hepatocyte differentiation protocol in order to generate hepatocytes displaying the complete functionality of mature hepatocytes. Finally, on the transcriptional level, our results show stronger correlation and higher similarity of hPSC-HEP to AL than to FL. In addition, potential targets for further functional improvement of hPSC-HEP were also identified.
21.	Hillman, Thomas, 1978, et al. (författare) Moderating professional learning on social media - A balance between monitoring, facilitation and expert membership 2021 Ingår i: Computers and Education. - : Elsevier BV. - 0360-1315. ; 168 Tidskriftsartikel (refereegranskat)abstract The role that moderation plays in the effective functioning of online communities is relatively well studied in relation to both general free-time social media groups and discussion groups that are part of formal educational and professional learning initiatives. However, at the intersection of these domains, there are a growing number of large-scale informally-developed professional-learning groups. While this kind of group has been studied more generally, little attention has been paid to the particular moderation concerns at play in these hybrid online spaces. In this study, we examine moderation over a three-year period in a teacher-professional Facebook group with over 13,000 members. Maintaining an interpretivist stance while drawing on an exploratory statistical analysis of trace data to identify critical instances in the activity of the group, we adopt a Goffmanian approach to examine how moderation is performed. Based on this analysis, we find that moderation in the case group involved a particular balance of three different moderation concerns. In addition to the facilitation role that moderators are often described as having in groups associated with formal educational and professional learning initiatives, our findings show that moderation can also involve the monitoring of group norms more commonly associated with general free-time social media groups and the third moderation concern of acting as an expert member.
22.	Johansen, Kari, et al. (författare) Norovirus strains belonging to the GII.4 genotype dominate as a cause of nosocomial outbreaks of viral gastroenteritis in Sweden 1997-2005 - Arrival of new variants is associated with large nation-wide epidemics 2008 Ingår i: Journal of Clinical Virology. - : Elsevier BV. - 1386-6532 .- 1873-5967. ; 42:2, s. 129-134 Tidskriftsartikel (refereegranskat)abstract Background: In recent years an increase of the incidence of nosocomial outbreaks caused by noroviruses has been observed throughout Sweden, with high peaks noted in the winter seasons 2002/2003 and 2004/2005, respectively. Objectives: To phylogenetically characterize norovirus strains causing nosocomial outbreaks from 1997 to 2005 and estimate the impact of norovirus-like disease on the Swedish health care system during the peak season 2002/2003 when a new variant of norovirus occurred. Study design: Stool samples from 115 randomly selected nosocomial outbreaks occurring during 1997-2005 throughout Sweden were studied by RT-PCR and sequencing. In addition, to investigate the impact on the health-care system, a questionnaire was distributed to infection control units (n = 90) serving all Swedish hospitals, nursing homes and other health-care institutions during the largest epidemic of nosocomial outbreaks. Results: Sequencing of 279 nucleotides of the norovirus RNA polymerase gene in stools containing norovirus RNA showed that strains belonging to the GII.4 genotype dominated. Each of the two large epidemics was due to a new variant within this cluster. The questionnaire revealed that 30,000-35,000 episodes of nosocomial norovirus-like infections occurred in 80 of 82 major Swedish hospitals affected in 2002/2003. Conclusion: New norovirus variants within the cluster GGII.4 may have a major impact on the health-care system. (c) 2008 Elsevier B.V. All rights reserved.
23.	Kaisdotter Andersson (Jonsson), Annika, et al. (författare) Methodology investigation of expirograms for enabling contact free breath alcohol analysis 2009 Ingår i: Journal of Breath Research. - : IOP Publishing. - 1752-7155 .- 1752-7163. ; 3:3, s. 036002- Tidskriftsartikel (refereegranskat)abstract The present techniques for breath alcohol determination have usability limitations concerning practical use and the time and effort required for the test person. The rationale of the physiological assumptions in a recently demonstrated technique for breath analysis without a mouthpiece is investigated in this paper. Expirograms quantifying ethanol, carbon dioxide (CO2) and water (H2O) from 30 test subjects were analysed, with respect to the influence of individual variations in end-expiratory CO2 and H2O concentrations, and possible benefits from simultaneous measurement of CO2 or H2O. Both healthy subjects and patients suffering from pulmonary diseases performed breath tests with small and maximum volume expiration. The breath tests were recorded basically with a standard evidential instrument using infrared absorption spectroscopy, and equipped with a mouthpiece. Average concentrations were significantly higher for the maximum than for the small expirations. For the maximum expirations, the healthy subjects had a significantly higher end-expired PCO2 of 4.4 ± 0.5 kPa (mean ± standard deviation) than the patients (3.9 ± 0.7 kPa). The corresponding values for H2O were 39 ± 1 and 38 ± 1 mg l−1. The results indicate that the CO2 variability is consistent with the requirements of accuracy for alcohol ignition interlocks. In addition, CO2 as tracer gas is preferable to H2O due to its low concentration in ambient air. In instruments for evidential purposes H2O may be required as tracer gas for increased accuracy. Furthermore, the study provides support for early determination of breath alcohol concentration, indicating that determination after 2 s will introduce an additional random error of 0.02 mg l−1 or less.
24.	Klemetz, Viktor, et al. (författare) Nationell luftövervakning : Sakrapport med data från övervakning inom Programområde Luft t. o. m. 2021 2023 Rapport (övrigt vetenskapligt/konstnärligt)abstract Naturvårdsverket ansvarar för den nationella luftövervakningen i bakgrundsmiljö. I rapporten redovisas resultat från verksamheten inom Programområde Luft avseende mätningar (genomförda av IVL Svenska Miljöinstitutet (IVL),Institutionen för Miljövetenskap vid Stockholms universitet (SU), Institutionen för Mark och Miljö vid Sveriges lantbruksuniversitet (SLU), Chalmers tekniska högskola och Sveriges meteorologiska och hydrologiska institut (SMHI) till och med 2021 samt regionala modellberäkningar (utförda av SMHI) till och med 2020. För flertalet av de luftföroreningskomponenter som övervakas inom den nationella miljöövervakningen har det, sedan mätningarna startade för mellan 20 och 45 år sedan, generellt skett en avsevärd förbättring avseende såväl halter i luft som deposition i bakgrundsmiljö.Utvecklingen har dock varierat i något olika utsträckning beroende på komponenter och lokalisering i landet. Föroreningsbelastningen är oftast lägre ju längre norrut i landet man kommer.För de flesta ämnen som det finns miljökvalitetsnormer (MKN) respektive miljömål för ligger halterna avsevärt lägre än angivna gräns- och målvärden. Halterna av marknära ozon överskrider i dagsläget MKN för hälsa vid ett flertal mätstationer i södra Sverige.För såväl partiklar (i form av PM2,5) och bensen (i urban bakgrund) är risken låg att haltnivåer överstiger miljömålens preciseringar.
25.	Kriit, Hedi Katre, et al. (författare) Using Distributed Lag Non-Linear Models to Estimate Exposure Lag-Response Associations between Long-Term Air Pollution Exposure and Incidence of Cardiovascular Disease 2022 Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 19:5 Tidskriftsartikel (refereegranskat)abstract Long-term air pollution exposure increases the risk for cardiovascular disease, but little is known about the temporal relationships between exposure and health outcomes. This study aims to estimate the exposure-lag response between air pollution exposure and risk for ischemic heart disease (IHD) and stroke incidence by applying distributed lag non-linear models (DLNMs). Annual mean concentrations of particles with aerodynamic diameter less than 2.5 µm (PM2.5 ) and black carbon (BC) were estimated for participants in five Swedish cohorts using dispersion models. Simultaneous estimates of exposure lags 1–10 years using DLNMs were compared with separate year specific (single lag) estimates and estimates for lag 1–5-and 6–10-years using moving average exposure. The DLNM estimated no exposure lag-response between PM2.5 total, BC, and IHD. However, for PM2.5 from local sources, a 20% risk increase per 1 µg/m3 for 1-year lag was estimated. A risk increase for stroke was suggested in relation to lags 2–4-year PM2.5 and BC, and also lags 8–9-years BC. No associations were shown in single lag models. Increased risk estimates for stroke in relation to lag 1–5-and 6–10-years BC moving averages were observed. Estimates generally supported a greater contribution to increased risk from exposure windows closer in time to incident IHD and incident stroke. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
26.	Lantz-Andersson, Annika, 1961, et al. (författare) Sharing repertoires and sharing apps - Norms for participation in a teacher profession-based social media group 2016 Ingår i: Paper for EARLI – SIG 10, 21 and 25 conference 28-29 August, 2016, Tartu, Estonia. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
27.	Lantz-Andersson, Annika, 1961, et al. (författare) Sharing repertoires in a teacher professional Facebook group 2017 Ingår i: Learning, Culture and Social Interaction. - : Elsevier BV. - 2210-6561. ; 15, s. 44-55 Tidskriftsartikel (refereegranskat)abstract This study explores participation in a teacher self-organised profession-based Facebook group discussing the Flipped Classroom (FC) approach. Methodologically our findings are based on computational content analysis of group activity and accompanying in-depth analysis of the communication in selected discussion threads. The findings show that sharing of material and social exchange becomes intertwined and that three double-edged participatory themes emerge: (1) requesting and giving tips, (2) asking for and providing concrete instructional examples, and (3) questioning and justifying the FC approach. In instances where the established repertoires are challenged, critical discussions emerge that nurture collegial learning and stimulate reflections on teaching practices.
28.	Lundin, Mona, 1976, et al. (författare) Higher education dominance and siloed knowledge: a systematic review of flipped classroom research 2018 Ingår i: International Journal of Educational Technology in Higher Education. - : Springer Science and Business Media LLC. - 2365-9440. ; 15 Forskningsöversikt (refereegranskat)abstract This structured review examined (academic) publications on flipped or inverted classrooms based on all Scopus database (n = 530) references available until mid-June 2016. The flipped or inverted classroom approach has gained widespread attention during the latest decade and is based on the idea of improving student learning by prepared self-studies via technology-based resources (‘flips’) followed by high-quality, in-class teaching and learning activities. However, only a few attempts have been made to review the knowledge of the field of interest more systematically. This article seeks to address this problem and investigates what constitutes the research on flipped classrooms and, in particular, to examine the knowledge contributions with the field so far in relation to the wider research topic of educational technology. This review found that the current state of flipped classrooms as a field of interest is growing fast, with a slight conference preference and a focus on higher education and STEM (science, technology, engineering and math) area contributions, with the US as the predominant geographical context. It is concluded that studies on flipped classrooms are dominated by studies in higher education sector and are relatively local in character. The research tends not to interact beyond the two clusters of general education/educational technology and subject-specific areas. This implies that knowledge contributions related to the flipped classroom approach are relatively siloed and fragmented and have yet to stabilise. Academically and socially, the research is quite scattered, and only local evidence and experiences are available. The knowledge contributions within this field of interest seem to be anecdotal rather than systematically researched. To a large extent, the research lacks anchoring in, for example, learning theory or instructional design known from educational technology traditions and which would have helped much of the flipped classroom research to examine aspects of the flipped classroom approach more fully.
29.	Lundin, Mona, 1976, et al. (författare) Social Media As Arenas For Teacher Professional Development 2017 Ingår i: Konferens bidrag: ECER 2017 Copenhagen - The European Conference on Educational Research. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
30.	Moberg, Christina, et al. (författare) De unga gör helt rätt när de stämmer staten 2022 Ingår i: Aftonbladet. - 1103-9000. Tidskriftsartikel (populärvet., debatt m.m.)abstract 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
31.	Napoleone, Antonino, et al. (författare) Fed-batch production assessment of a tetravalent bispecific antibody : A case study on piggyBac stably transfected HEK293 cells 2021 Ingår i: New Biotechnology. - : Elsevier BV. - 1871-6784 .- 1876-4347. ; 65, s. 9-19 Tidskriftsartikel (refereegranskat)abstract The transition from preclinical biological drug development into clinical trials requires an efficient upscaling process. In this context, bispecific antibody drugs are particularly challenging due to their propensity to form aggregates and generally produce low titers. Here, the upscaling process for a tetravalent bispecific antibody expressed by a piggyBac transposon-mediated stable HEK293 cell pool has been evaluated. The project was performed as a case study at Testa Center, a non-GMP facility for scale-up testing of biologics in Sweden, and encompassed media adaptation strategies, fed-batch optimization and a novel antibody purification technology. The cell pool was adapted to different culture media for evaluation in terms of cell viability and titers compared to its original Expi293 Expression Medium. These parameters were assessed in both sequential stepwise adaption and direct media exchanges. By this, a more affordable medium was identified that did not require stepwise adaptation and with similar titers and viability as in the Expi293 Expression Medium. Fed-batch optimizations resulted in culture densities reaching up to 20 x 106 viable cells/mL with over 90 % viability 12 days postinoculum, and antibody titers three times higher than corresponding batch cultures. By implementing a novel high-speed protein A fiber technology (Fibro PrismA) with a capture residence time of only 7.5 s, 8 L of supernatant could be purified in 4.5 h without compromising the purity, structural integrity and function of the bispecific antibody. Results from this study related to medium adaptation and design of fed-batch protocols will be highly beneficial during the forthcoming scale-up of this therapeutic antibody.
32.	Nilsson Sommar, Johan, et al. (författare) Long-term exposure to particulate air pollution and black carbon in relation to natural and cause-specific mortality: a multicohort study in Sweden 2021 Ingår i: Bmj Open. - : BMJ. - 2044-6055. ; 11:9 Tidskriftsartikel (refereegranskat)abstract Objectives To estimate concentration-response relationships for particulate matter (PM) and black carbon (BC) in relation to mortality in cohorts from three Swedish cities with comparatively low pollutant levels. Setting Cohorts from Gothenburg, Stockholm and Umea, Sweden. Design High-resolution dispersion models were used to estimate annual mean concentrations of PM with aerodynamic diameter <= 10 mu m (PM10) and <= 2.5 mu m (PM2.5), and BC, at individual addresses during each year of follow-up, 1990-2011. Moving averages were calculated for the time windows 1-5 years (lag1-5) and 6-10 years (lag6-10) preceding the outcome. Cause-specific mortality data were obtained from the national cause of death registry. Cohort-specific HRs were estimated using Cox regression models and then meta-analysed including a random effect of cohort. Participants During the study period, 7 340 cases of natural mortality, 2 755 cases of cardiovascular disease (CVD) mortality and 817 cases of respiratory and lung cancer mortality were observed among in total 68 679 individuals and 689 813 person-years of follow-up. Results Both PM10 (range: 6.3-41.9 mu g/m(3)) and BC (range: 0.2-6.8 mu g/m(3)) were associated with natural mortality showing 17% (95% CI 6% to 31%) and 9% (95% CI 0% to 18%) increased risks per 10 mu g/m(3) and 1 mu g/m(3) of lag1-5 exposure, respectively. For PM2.5 (range: 4.0-22.4 mu g/m(3)), the estimated increase was 13% per 5 mu g/m(3), but less precise (95% CI -9% to 40%). Estimates for CVD mortality appeared higher for both PM10 and PM2.5. No association was observed with respiratory mortality. Conclusion The results support an effect of long-term air pollution on natural mortality and mortality in CVD with high relative risks also at low exposure levels. These findings are relevant for future decisions concerning air quality policies.
33.	Nordin, Annika, et al. (författare) Emergent programme theories of a national quality register - a longitudinal study in Swedish elderly care 2017 Ingår i: Journal of Evaluation In Clinical Practice. - : John Wiley & Sons. - 1356-1294 .- 1365-2753. ; 23:6, s. 1329-1335 Tidskriftsartikel (refereegranskat)abstract Rationale, aim, and objective: This study aimed to explore programme theories of a national quality register. A programme theory is a bundle of assumptions underpinning how and why an improvement initiative functions. The purpose was to examine and establish programme theories of a national quality register widely used in Sweden: Senior alert. The paper reports on how programme theories among change recipients emerge in relation to the established programme theory of the initiator.Methods: A qualitative approach and a longitudinal research design were used. To develop programme theories among change recipients, individual semistructured interviews were conducted. Three sets of interviews were conducted in the period of 2011 to 2013, totalling 22 interviews. In addition, 4 participant observations were made. To develop the initiator's programme theory, an iterative multistage collaboration process between the researchers and the initiator was used. A directed content analysis was used to analyse data.Findings: The initiator and change recipients described similar programme logics, but differing programme theories. With time, change recipients' programme theories emerged. Their programme theories converged and became more like the programme theory of the initiator.Conclusions: This study has demonstrated the importance of making both the initiator's and change recipients' programme theories explicit. To learn about conditions for improvement initiatives, comparisons between their programme theories are valuable. Differences in programme theories provide information on how initiators can customize support for their improvement initiatives. Similar programme logics can be underpinned by different programme theories, which can be deceptive. Programme theories emerge over time and need to be understood as dynamic phenomena.
34.	Nordin, Annika (författare) Expressions of shared interpretations - Intangible outcomes of continuous quality improvement efforts in health- and elderly care 2017 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract This thesis is anchored in improvement science, the research field of improvement. Improvement science describes and explores improvement in real-life contexts and “system of profound knowledge” (Deming, 2000) is a cornerstone. Performance measures, including their variation over time, are fundamental in the research and evaluation of outcomes of continuous quality improvement efforts (CQI efforts). However, the strong emphasis on operationalisations and measurements risks overshadowing other kinds of outcomes to which CQI efforts can lead.Research has shown that it is advantageous that those performing change have some kind of “sharedness”, e.g. shared cognitions, understanding, knowledge, interpretations or frame of reference. Despite the diversity of concepts and scientific studies, “sharedness” is mainly described as a prerequisite for change.This thesis addresses the call to broaden the scientific approach in improvement science and to take advantage of knowledge developed since Deming's time. It has a point of departure in the presumption that CQI efforts also lead to intangible outcomes; qualitative effects that are not easily captured with traditional performance measures. The concept “Expressions of shared interpretations” is used to study “sharedness” as intangible outcomes.The overall aim with this thesis is to explore Expressions of shared interpretations as intangible outcomes of CQI efforts from the perspective of clinical microsystems and healthcare professionals. The specific aims are to examine and establish how Expressions of shared interpretations develop, influence CQI efforts and change over time.Using a qualitative approach, this thesis comprises four papers, based on three studies. The empirical context is healthcare and welfare organizations providing care: hospital clinics in county councils/regions and nursing homes in municipalities. The studies include time periods from one to three and a half years, totalling six years. Expressions of shared interpretations inherently mean that the methods for data analysis need to be based on commonalities or patterns in the data. In this thesis three methods are used: qualitative content analysis, thematic analysis and directed content analysis. To examine time-related changes, year-to-year comparative analyses of themes and categories are done.To explore Expressions of shared interpretations, different theoretical frameworks are used: team cognitions (Paper 1), sensemaking theory (Paper 2), cognitive shifts (Paper 3) and programme theories (Paper 4).A directed content analysis is applied in a meta-analysis of the results presented in the four papers. The results indicate that Expressions of shared interpretations develop as intangible outcomes of CQI efforts and a general programme theory of CQI efforts in health- and elderly care is developed, illuminating how Expressions of shared interpretations change and influence CQI efforts. The general programme theory incorporates the PDSA cycle and describes the complex, interconnected and continuous development of Expressions of shared interpretations. It also illuminates how Expressions of shared interpretations provide change performers with momentum to engage in forthcoming PDSA cycles and how sensemaking is a central activity.CQI efforts in health- and elderly care are characterised by a “just get on with it” attitude, while in this thesis, thoughtfulness is emphasized. Existing improvement tools support collaboration, creativity and analysis of critical aspects of the operations, yet none of the improvement tools help change performers gain understanding of the CQI effort as such. To address this, this thesis suggests that change performers complement the use of improvement tools with an inquiring mind, that they collaborate in thoughtful dialogues and that leaders function as inquirers. To support this posture, the widely used Model for improvement is complemented with a fourth question: What are our assumptions? The question pinpoints the need to be thoughtful in every step of the CQI effort, not just in the analysis of the problem at hand.
35.	Nordin, Annika, et al. (författare) Prospective sensemaking of a national quality register in health care and elderly care 2018 Ingår i: Leadership in Health Services. - : Emerald Group Publishing Limited. - 1751-1879 .- 1751-1887. ; 31:4, s. 398-408 Tidskriftsartikel (refereegranskat)abstract PurposeThe purpose of this paper is to examine how external change agents (ECAs) engaged to disseminate a national quality register (NQR) called Senior alert nationwide in the Swedish health care and elderly care sectors interpret their work. To study this, sensemaking theories are used.Design/methodology/approachThis is a qualitative inductive interview study including eight ECAs. To analyze the data, a thematic analysis is carried out.FindingsWell-disseminated NQRs support health care organizations’ possibility to work with quality improvement and to improve care for patient groups. NQRs function as artifacts that can influence how health care professionals make sense of their work. In this paper, a typology depicting how the ECAs make sense of their dissemination work has been developed. The ECAs are engaged in prospective sensemaking. They describe their work as being about creating future good results, both for patients and affiliated organizations, and they can balance different quality aspects.Originality/valueThe number of NQRs increased markedly in Sweden and elsewhere, but there are few reports on how health care professionals working with the registers interpret their work. The use of ECAs to disseminate NQRs is a novel approach. This paper describes how the ECAs are engaged in prospective sensemaking – an under-researched perspective of the sensemaking theory.
36.	Nordin, Annika, et al. (författare) Sensemaking and cognitive shifts – learning from dissemination of a National Quality Register in health care and elderly care 2018 Ingår i: Leadership in Health Services. - : Emerald Group Publishing Limited. - 1751-1879 .- 1751-1887. ; 31:4, s. 371-383 Tidskriftsartikel (refereegranskat)abstract PurposeThe purpose of this study is to examine and establish how sensemaking develops among a group of external change agents (ECAs) engaged to disseminate a national quality register nationwide in Swedish health care and elderly care. To study the emergent sensemaking, the theoretical concept of cognitive shift has been used.Design/methodology/approachThe data collection method included individual semi-structured interviews, and two sets of interviews (initial sensemaking and renewed sensemaking) have been conducted. Based on a typology describing how ECAs interpret their work, structural analyses and comparisons of initial and renewed sensemaking are made and illuminated in spider diagrams. The data are then analyzed to search for cognitive shifts.FindingsThe ECAs’ sensemaking develops. Three cognitive shifts are identified, and a new kind of issue-related cognitive shift, the outcome-related cognitive shift, is suggested. For the ECAs to customize their work, they need to be aware of how they interpret their own work and how these interpretations develop over time.Originality/valueThe study takes a novel view of the interrelated concepts of sensemaking and sensegivers and points out the cognitive shifts as a helpful theoretical concept to study how sensemaking develops.
37.	Peterson, Louise, 1965, et al. (författare) “Going on Trial”: Teachers’ team performance in social media groups when facing problematic work-related issues 2019 Ingår i: Virtual Learning Sites as Languaging Spaces - Critical Issues on Languaging Research in Changing Eduscapes. - Cham, Switzerland : Palgrave Macmillan. - 9783030269296 ; , s. 241-268 Bokkapitel (refereegranskat)abstract This study examines how a problematic work-related issue is raised in a large self-organized thematic professional Facebook group and how the topic is continued in the discussion that follows. Based on big data from a large corpus assembled through the Facebook Application Programming Interface, a unique case thread is selected for in-depth analysis. The aim is to analyse how social support is performed through professional identity work in moment-by-moment online interactions. The findings illustrate how the performance of social support in a thread includes both supportive and remedial interchanges that reveal emergent impression management and a mutually shaped professional teacher identity. Further, the findings indicate that member performance, generally relatively neutral in non-critical discussion threads, changes in relation to the problematic work-related issue in the post that challenges the collective identity of the group. This means that the interaction engenders cooperative and supportive interchanges that motivate members to perform as a team and cooperate as supportive team members.
38.	Peterson, Louise, 1965, et al. (författare) Professional identity management in a thematic Facebook group 2017 Ingår i: European Association for Research on Learning and Instruction conference, EARLI. 29 August – 2 September, University of Tampere, Tampere, Finland.. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
39.	Sjöberg, Karin, et al. (författare) Nationell miljöövervakning - luft 2013 Rapport (övrigt vetenskapligt/konstnärligt)abstract På uppdrag av Naturvårdsverket, Enheten för luft och klimat, bedrivs mätningar av luftens och nederbördens sammansättning, främst i bakgrundsmiljö, inom olika mätprogram. IVL Svenska Miljöinstitutet har ansvar för genomförandet av merparten av verksamheten inom luftområdet. Därtill ombesörjer både Institutionen för Tillämpad Miljöteknik (ITM) vid Stockholms universitet och Institutionen för Mark och Miljö vid Sveriges lantbruks-universitet (SLU) delar av övervakningen. SMHI genomför, med hjälp av beräknings-modeller, en geografisk kartläggning av halter i luft och deposition av försurande och övergödande ämnen på nationell nivå. De samlade resultaten från mätningar till och med 2011 och beräkningar till och med 2010 redovisas i denna rapport. Det har generellt sett skett en avsevärd förbättring avseende såväl halter i luft som deposition i bakgrundsmiljö för flertalet av de luftförorenings-komponenter som övervakas inom den nationella miljöövervakningen sedan mätningarna startade för mellan 10 och 30 år sedan. Utvecklingen har dock varierat i något olika utsträckning beroende på komponent och lokalisering i landet. Föroreningsbelastningen är oftast lägre ju längre norrut man kommer. För de flesta de ämnen som det finns miljökvalitetsnormer (MKN) respektive miljömål för ligger halterna avsevärt lägre än angivna gräns- och målvärden. Halterna av ozon överskrider i dagsläget MKN för hälsa. För såväl ozon som för bensen (i urban bakgrund) finns risk för haltnivåer som överstiger miljömålens preciseringar.
40.	Stockfelt, Leo, 1981, et al. (författare) Long-Term Exposure to Particulate Air Pollution, Black Carbon, and Their Source Components in Relation to Ischemic Heart Disease and Stroke 2019 Ingår i: Journal of Environmental Health Perspectives. - Durham : National Institute of Environmental Health Sciences. - 0091-6765 .- 1552-9924. ; 127:10 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Long-term exposure to particulate matter (PM) in ambient air has been associated with cardiovascular mortality, but few studies have considered incident disease in relation to PM from different sources.OBJECTIVES: We aimed to study associations between long-term exposure to different types of PM and sources, and incident ischemic heart disease (IHD) and stroke in three Swedish cities.METHODS: ), and black carbon (BC) from road wear, traffic exhaust, residential heating, and other sources in Gothenburg, Stockholm, and Umeå. Registry data for participants from four cohorts were used to obtain incidence of IHD and stroke for first hospitalization or death. We constructed time windows of exposure for same-year, 1- to 5-y, and 6- to 10-y averages preceding incidence from annual averages at residential addresses. Risk estimates were based on random effects meta-analyses of cohort-specific Cox proportional hazard models.RESULTS: exposure from residential heating.DISCUSSION: Few consistent associations were observed between different particulate components and IHD or stroke. However, long-term residential exposure to locally emitted BC from traffic exhaust was associated with stroke incidence. The comparatively low exposure levels may have contributed to the paucity of associations.
41.	Tammelin, Ann, et al. (författare) Apropå! Kläderna i vården : Blanda inte ihop identifiering och hygienrutiner 2011 Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 108:9, s. 453- Tidskriftsartikel (refereegranskat)
42.	Veni, veni Emmanuel : Uppsala domkyrkas gosskör 100 år 2020 Bok (populärvet., debatt m.m.)abstract Körsång har klingat genom seklerna och speglat samhället. 100-årsjubilerande Uppsala domkyrkas gosskör är en del av detta genom vardagligt slit, konstnärliga framgångar, söndagligt gudstjänstsjungande och musikalisk glädje. Klingande musikalisk verksamhet är också en del av en tradition för Uppsala universitet och har så varit under dess drygt 500-åriga tillvaro. Kyrka och universitet har följts åt i samarbete och samverkan där musiken ofta varit en gemensam nämnare. Boken innehåller en längre historik samt kortare bidrag från personer som varit och är engagerade i Uppsala domkyrkas gosskörs verksamhet.
43.	Viberg, Olga, 1982-, et al. (författare) Integrating digital technology in mathematics education : A Swedish case study 2023 Ingår i: Interactive Learning Environments. - : Routledge. - 1049-4820 .- 1744-5191. ; 31:1, s. 232-243 Tidskriftsartikel (refereegranskat)abstract Integrating digital technology in education is challenging. This study reports on three high school mathematics classes where teachers attempted to improve their teaching and student learning by using a digital tool. For analysis we use the Information System Artifact model Lee et al. (2015) which distinguishes between three integrated sub-artifacts, the technological, the informational and the social and the Structurational Practice Lens to educational technology Halperin (2017). Using interviews and observations we find the major obstacle for student learning is a less developed social artifact. Students have difficulties using the tool effectively when teachers do not work to develop shared practices in technology use. When teachers do not themselves use the tool actively, they do not fully understand how students can learn from it, neither can they help them in synthesizing teacher- and tool instructions. Students end up having "two masters" competing rather than integrated teacher instruction and technology assistance.
44.	Wahlström, Annika, 1975, et al. (författare) Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease. 2008 Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 112:4, s. 1357-65 Tidskriftsartikel (refereegranskat)abstract Hyperactive signaling through the RAS proteins is involved in the pathogenesis of many forms of cancer. The RAS proteins and many other intracellular signaling proteins are either farnesylated or geranylgeranylated at a carboxyl-terminal cysteine. That isoprenylcysteine is then carboxyl methylated by isoprenylcysteine carboxyl methyltransferase (ICMT). We previously showed that inactivation of Icmt mislocalizes the RAS proteins away from the plasma membrane and blocks RAS transformation of mouse fibroblasts, suggesting that ICMT could be a therapeutic target. However, nothing is known about the impact of inhibiting ICMT on the development of malignancies in vivo. In the current study, we tested the hypothesis that inactivation of Icmt would inhibit the development or progression of a K-RAS-induced myeloproliferative disease in mice. We found that inactivating Icmt reduced splenomegaly, the number of immature myeloid cells in peripheral blood, and tissue infiltration by myeloid cells. Moreover, in the absence of Icmt, the ability of K-RAS-expressing hematopoietic cells to form colonies in methylcellulose without exogenous growth factors was reduced dramatically. Finally, inactivating Icmt reduced lung tumor development and myeloproliferation phenotypes in a mouse model of K-RAS-induced cancer. We conclude that inactivation of Icmt ameliorates phenotypes of K-RAS-induced malignancies in vivo.
45.	Weitoft, Maria, et al. (författare) Controlled and uncontrolled asthma display distinct alveolar tissue matrix compositions 2014 Ingår i: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921. ; 15 Tidskriftsartikel (refereegranskat)abstract Objective: Whether distal inflammation in asthmatics also leads to structural changes in the alveolar parenchyma remains poorly examined, especially in patients with uncontrolled asthma. We hypothesized that patients who do not respond to conventional inhaled corticosteroid therapy have a distinct tissue composition, not only in central, but also in distal lung. Methods: Bronchial and transbronchial biopsies from healthy controls, patients with controlled atopic and patients with uncontrolled atopic asthma were processed for immunohistochemical analysis of fibroblasts and extracellular matrix molecules: collagen, versican, biglycan, decorin, fibronectin, EDA-fibronectin, matrix metalloproteinase (MMP)-9 and tissue-inhibitor of matrix metalloproteinase (TIMP)-3. Results: In central airways we found increased percentage areas of versican and decorin in patients with uncontrolled asthma compared to both healthy controls and patients with controlled asthma. Percentage area of biglycan was significantly higher in both central airways and alveolar parenchyma of patients with uncontrolled compared to controlled asthma. Ratios of MMP-9/TIMP-3 were decreased in both uncontrolled and controlled asthma compared to healthy controls. In the alveolar parenchyma, patients with uncontrolled asthma had increased percentage areas of collagen, versican and decorin compared to patients with controlled asthma. Patients with uncontrolled asthma had significantly higher numbers of myofibroblasts in both central airways and alveolar parenchyma compared to patients with controlled asthma. Conclusions: Tissue composition differs, in both central and distal airways, between patients with uncontrolled and controlled asthma on equivalent doses of ICS. This altered structure and possible change in tissue elasticity may lead to abnormal mechanical properties, which could be a factor in the persistent symptoms for patients with uncontrolled asthma.
46.	Åberg, Annika, et al. (författare) Exposure assessment at a PCDD/F contaminated site in Sweden : field measurements of exposure media and serum analysis 2010 Ingår i: Environmental Science and Pollution Research. - Berlin / Heidelberg : Springer. - 0944-1344 .- 1614-7499. ; 17:1, s. 26-39 Tidskriftsartikel (refereegranskat)abstract BACKGROUND, AIM, AND SCOPE: The main pathway for human exposure to the highly toxic polychlorinated-p-dioxins and polychlorinated furans [polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs)] is via dietary intake. Other exposure pathways may, however, be important in close proximity to point sources, such as wood preservation sites, where PCDD/F contaminated chlorophenols (CP) were previously used. In this study, a heavily PCDD/F contaminated CP saw mill site in Sweden was investigated. Human exposure through a broad spectrum of exposure pathways was assessed. Such studies are in demand since the question whether contaminated sites represent a current or future risk can only be answered by detailed site-specific risk assessments. MATERIALS AND METHODS: Sampling of exposure media (soil, air, groundwater, raspberries, carrots, potatoes, grass, milk, eggs, and chicken fodder) was made. Exposure media concentrations and congener distribution patterns were used to investigate the mobilization of PCDD/Fs from soil to the environment and to calculate exposure levels for adults. Blood serum levels from site-exposed and control individuals were also analyzed. RESULTS: Congener distribution patterns at the site were generally dominated by a specific marker congener (1234678-HpCDF), which is highly abundant in the polluted soil. The dioxin toxic equivalents (TEQ) concentrations were notably elevated as compared to national reference samples for most exposure media, and the marker congener was a major contributor to increased TEQ levels. There were also indications of soil-to-air volatilization of tetra- and penta-CDD/Fs. People who participated in the restoration of a contaminated building showed higher levels of 1234678-HpCDF compared to controls, and calculated exposure levels suggest that several site-specific exposure routes may be of importance for the daily intake of PCDD/F. CONCLUSIONS, RECOMMENDATIONS, AND PERSPECTIVES: Despite low mobility of higher chlorinated PCDD/Fs, these contaminants were transferred from the polluted soil to the surroundings and into human tissue. The extent of increased exposure from contaminated sites depends on the PCDD/F source strength of the soil, composition of the pollution, human activities, and dietary patterns of the residents. Impact from the contaminated soil on other exposure media was seen also for areas with low to moderate soil contamination. In the future, not only the levels of PCDD/F soil pollution but also the composition must be considered in risk assessments of contaminated sites.
47.	Abel, I, et al. (författare) Overview of the JET results with the ITER-like wall 2013 Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002- Tidskriftsartikel (refereegranskat)abstract Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
48.	Acevedo, Nathalie, et al. (författare) DNA Methylation Levels in Mononuclear Leukocytes from the Mother and Her Child Are Associated with IgE Sensitization to Allergens in Early Life 2021 Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 22:2 Tidskriftsartikel (refereegranskat)abstract DNA methylation changes may predispose becoming IgE-sensitized to allergens. We analyzed whether DNA methylation in peripheral blood mononuclear cells (PBMC) is associated with IgE sensitization at 5 years of age (5Y). DNA methylation was measured in 288 PBMC samples from 74 mother/child pairs from the birth cohort ALADDIN (Assessment of Lifestyle and Allergic Disease During INfancy) using the HumanMethylation450BeadChip (Illumina). PBMCs were obtained from the mothers during pregnancy and from their children in cord blood, at 2 years and 5Y. DNA methylation levels at each time point were compared between children with and without IgE sensitization to allergens at 5Y. For replication, CpG sites associated with IgE sensitization in ALADDIN were evaluated in whole blood DNA of 256 children, 4 years old, from the BAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology) cohort. We found 34 differentially methylated regions (DMRs) associated with IgE sensitization to airborne allergens and 38 DMRs associated with sensitization to food allergens in children at 5Y (Sidak p <= 0.05). Genes associated with airborne sensitization were enriched in the pathway of endocytosis, while genes associated with food sensitization were enriched in focal adhesion, the bacterial invasion of epithelial cells, and leukocyte migration. Furthermore, 25 DMRs in maternal PBMCs were associated with IgE sensitization to airborne allergens in their children at 5Y, which were functionally annotated to the mTOR (mammalian Target of Rapamycin) signaling pathway. This study supports that DNA methylation is associated with IgE sensitization early in life and revealed new candidate genes for atopy. Moreover, our study provides evidence that maternal DNA methylation levels are associated with IgE sensitization in the child supporting early in utero effects on atopy predisposition.
49.	Acevedo, Nathalie, et al. (författare) Epigenetic alterations in skin homing CD4(+)CLA(+) T cells of atopic dermatitis patients 2020 Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1 Tidskriftsartikel (refereegranskat)abstract T cells expressing the cutaneous lymphocyte antigen (CLA) mediate pathogenic inflammation in atopic dermatitis (AD). The molecular alterations contributing to their dysregulation remain unclear. With the aim to elucidate putative altered pathways in AD we profiled DNA methylation levels and miRNA expression in sorted T cell populations -(CD4(+), -CD4(+)CD45RA(+) naive, -CD4(+)CLA(+), and -CD8(+)) from adult AD patients and healthy controls (HC). Skin homing -CD4(+)CLA(+) T cells from AD patients showed significant differences in DNA methylation in 40 genes compared to HC (p < 0.05). Reduced DNA methylation levels in the upstream region of the interleukin-13 gene (IL13) in -CD4(+)CLA(+) T cells from AD patients correlated with increased IL13 mRNA expression in these cells. Sixteen miRNAs showed differential expression in -CD4(+)CLA(+) T cells from AD patients targeting genes in 202 biological processes (p < 0.05). An integrated network analysis of miRNAs and CpG sites identified two communities of strongly interconnected regulatory elements with strong antagonistic behaviours that recapitulated the differences between AD patients and HC. Functional analysis of the genes linked to these communities revealed their association with key cytokine signaling pathways, MAP kinase signaling and protein ubiquitination. Our findings support that epigenetic mechanisms play a role in the pathogenesis of AD by affecting inflammatory signaling molecules in skin homing -CD4(+)CLA(+) T cells and uncover putative molecules participating in AD pathways.
50.	Adamson, Lisa, et al. (författare) Teacher Instructions and Students´ Digital Literacy Practices 2013 Ingår i: IADIS International Conference Mobile Learning 2013. - Lisbon, Portugal. Konferensbidrag (övrigt vetenskapligt/konstnärligt)

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