| 1. |
- Andersson, K, et al.
(författare)
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Colloidal rare earth elements in a boreal river: Changing sources and distributions during the spring flood
- 2006
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Ingår i: Geochimica Et Cosmochimica Acta. - : Elsevier BV. - 0016-7037 .- 1872-9533. ; 70:13, s. 3261-3274
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Tidskriftsartikel (refereegranskat)abstract
- Variations in the physico-chemical speciation of the rare earth elements (REE) have been investigated in a subarctic boreal river during an intense spring flood event using prefiltered (< 100 mu m) samples, cross-flow (ultra)filtration (CFF), flow field-flow fractionation (FIFFF), and diffusive gradients in thin films (DGT). This combination of techniques has provided new information regarding the release and transport of the REE in river water. The colloidal material can be described in terms of two fractions dominated by carbon and iron, respectively. These two fractions, termed colloidal carrier phases, showed significant temporal changes in concentration and size distribution. Before the spring flood, colloidal carbon concentrations were low, the colloids being dominated by relatively large iron colloids. Colloidal concentrations increased sharply during the spring flood, with smaller carbon colloids dominating. Following the spring flood, colloidal concentrations decreased again, smaller carbon colloids still dominating. The REE are transported mainly in the particulate and colloidal phases. Before the spring flood, the REE composition of all measured fractions was similar to local till. During the spring flood, the REE concentrations in the colloidal and particulate fractions increased. The increase was most marked for the lighter REE, which therefore showed a strong enrichment when normalized to local till. Following the spring flood, the REE concentrations decreased again and reverted to a distribution similar to local till. These changes in the concentration and distributions of carbon iron and REE are interpreted in terms of changing hydrological flow paths in soil and bedrock which occur during the spring flood. (c) 2006 Elsevier Inc. All rights reserved.
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| 2. |
- Berglund, Anders, 1974-, et al.
(författare)
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THE PEDAGOGICAL DEVELOPERS INITIATIVE : SYSTEMATIC SHIFTS, SERENDIPITIES, AND SETBACKS
- 2017
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Ingår i: 13th International CDIO Conference in Calgary, Canada, June 18-22, 2017.
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Konferensbidrag (refereegranskat)abstract
- Pedagogical projects have often, at KTH Royal Institute of Technology, as well as elsewhere, been initiated and managed by individual enthusiasts rather than dedicated teams. This generally decreases the possibility of successful implementation of more ambitious ideas, e.g., changing educational programs, implementing the CDIO syllabus, or strengthening the pedagogical development of larger parts of the faculty. To enable wider and more effective change, KTH top management therefore launched a universityencompassing three-year project in 2014, in which a group of highly motivated teachers from all schools at KTH were appointed part-time pedagogical developers (PDs). The PDs were given the task of promoting pedagogical development and facilitate cooperation and knowledge exchange among faculty members, as described in two previous papers at CDIO conferences. From 2017, the outcomes of this project are supposed to be integrated parts of the KTH line organization. The project has led to numerous actions, which would have been difficult to set in motion unless given the freedom in time to explore and to develop into a collective effort rather than a myriad of individual “stand-alone” examples. By addressing key areas for pedagogical development, our group of dedicated faculty have tried to surpass the suboptimal "lock-in" of strict individual reasoning and to deal with surfaced questions and relevant issues in a broader collective manner. A major insight confirmed by the project and its many sub-projects has indeed been the fundamental importance of collegial discussions and the creation of processes that facilitate and support teacher cooperation. We have also, through discussions with faculty at KTH, confirmed the need for clearly defined, tangible incentives for teachers, motivating them to participate in pedagogical development activities, even if this means less time left for the traditional pathway to rewards within academia, i.e. research. In this paper, we chart changes that have occurred in the educational practices at KTH by describing and discussing the project’s focus on pedagogical development of faculty, actual execution of changes in the engineering educations, lessons learned along the way, and visions yet to be realised.
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| 3. |
- Bringert, Björn, 1979, et al.
(författare)
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Student Paper: HaskellDB Improved
- 2004
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Ingår i: Haskell '04: Proceedings of the ACM SIGPLAN workshop on Haskell. - 1581138504 ; , s. 108-115
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Konferensbidrag (refereegranskat)abstract
- We present an improved version of the HaskellDB database library. The original version relied on TRex, a Haskell extension supported only by the Hugs interpreter. We have replaced the use of TRex by a record implementation which uses more commonly implemented Haskell extensions. Additionally, HaskellDB now supports two different cross-platform database backends. Other changes include database creation functionality, bounded string support, performance enhancements, fixes to the optimisation logic, transaction support and more fine grained expression types.
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| 4. |
- Dahlqvist, Ralf, et al.
(författare)
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Temporal variations of colloidal carrier phases and associated trace elements in a boreal river
- 2007
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Ingår i: Geochimica et Cosmochimica Acta. - : Elsevier BV. - 0016-7037 .- 1872-9533. ; 71:22, s. 5339-5354
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Tidskriftsartikel (refereegranskat)abstract
- Elemental size distributions, from truly dissolved through colloidal to particulate, have been studied in a subarctic boreal river. The measurements, carried out during 2002, ranged from winter to summer conditions, including an intense spring flood event. Results are reported for a total of 42 elements. Size distributions were characterised using a combination of cross-flow (ultra)filtration (CFF), flow field-flow fractionation (FIFFF), and diffusive gradients in thin-films (DGT). The three techniques showed similar trends, but quantitative comparisons reveal some important differences that warrant further investigation. Previous work has identified two colloidal carrier phases in fresh waters, dominated by iron and carbon, respectively. The majority of the elements studied are associated with one or both of these colloidal carrier phases. The exceptions are the alkali metals and several anions that are only very weakly associated with colloidal material, and which therefore occur mainly as truly dissolved material (< 1 kDa in molecular weight). We discuss the likely origin for the two colloidal carrier phases and consider how associated trace elements fit into the geochemical framework. The relative affinities of the elements for iron and carbon colloidal carrier phases are related to their chemistries, and are compared with earlier data from the Delsjo Creek in southern Sweden. Elemental colloidal concentrations show strong seasonal variations related to changes in the colloidal carrier phase(s) with which they associate. In particular, many elements show a strong spring maximum in colloidal concentrations associated with the strong maximum in colloidal carbon concentration during the spring flood.
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| 5. |
- Abdelzaher, T., et al.
(författare)
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The aperiodic multiprocessor utilization bound for liquid tasks
- 2002
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Ingår i: 8th IEEE Real-Time and Embedded Technology and Applications Symposium, 2002. Proceedings. - 1545-3421. - 0769517390 ; , s. 173-184
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Konferensbidrag (refereegranskat)abstract
- Real-time scheduling theory has developed powerful tools for translating conditions on aggregate system utilization into per-task schedulability guarantees. The main breakthrough has been Liu and Layland's utilization bound for schedulability of periodic tasks. In 2001 this bound was generalized by Abdelzaher and Lu to the aperiodic task case. In this paper we further generalize the aperiodic bound to the case of multiprocessors, and present key new insights into schedulability, analysis of aperiodic tasks. We consider a special task model, called the liquid task model, representative of high-performance servers with aperiodic workloads, such as network routers, web servers, proxies, and real-time databases. For this model, we derive the optimal multiprocessor utilization bound, defined on a utilization-like metric we call "synthetic utilization". This bound allows developing constant-time admission control tests that provide utilization-based absolute delay, tees. We show that the real utilization of admitted tasks can be close to unity even when synthetic utilization is kept below the bound. Thus, our results lead to multiprocessor systems which combine constant-time admission control with high utilization while making no periodicity assumptions regarding the task arrival pattern.
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| 6. |
- Andersson-Assarsson, Johanna C., 1974, et al.
(författare)
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Evolution of age-related mutation-driven clonal haematopoiesis over 20 years is associated with metabolic dysfunction in obesity
- 2023
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Ingår i: Ebiomedicine. - 2352-3964. ; 92
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Tidskriftsartikel (refereegranskat)abstract
- Background Haematopoietic clones caused by somatic mutations with >= 2% variant allele frequency (VAF) increase with age and are linked to risk of haematological malignancies and cardiovascular disease. Recent observations suggest that smaller clones (VAF<2%) are also associated with adverse outcomes. Our aims were to determine the prevalence of clonal haematopoiesis driven by clones of variable sizes in individuals with obesity treated by usual care or bariatric surgery (a treatment that improves metabolic status), and to examine the expansion of clones in relation to age and metabolic dysregulation over up to 20 years.Methods Clonal haematopoiesis-driver mutations (CHDMs) were identified in blood samples from participants of the Swedish Obese Subjects intervention study. Using an ultrasensitive assay, we analysed single-timepoint samples from 1050 individuals treated by usual care and 841 individuals who had undergone bariatric surgery, and multiple-timepoint samples taken over 20 years from a subset (n = 40) of the individuals treated by usual care.Findings In this explorative study, prevalence of CHDMs was similar in the single-timepoint usual care and bariatric surgery groups (20.6% and 22.5%, respectively, P = 0.330), with VAF ranging from 0.01% to 31.15%. Clone sizes increased with age in individuals with obesity, but not in those who underwent bariatric surgery. In the multiple-timepoint analysis, VAF increased by on average 7% (range -4% to 24%) per year and rate of clone growth was negatively associated with HDL-cholesterol (R = -0.68, 1.74 E-04).Interpretation Low HDL-C was associated with growth of haematopoietic clones in individuals with obesity treated by usual care.
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| 7. |
- Andersson, Björn, 1974, et al.
(författare)
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Fixed-Priority Preemptive Multiprocessor Scheduling: To Partition or not to Partition
- 2000
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Ingår i: Proceedings of the IEEE Conference on Real-Time Computing Systems and Applications, December 12−14, 2000, Cheju Island, South Korea. - 1530-1427. - 0769509304 ; , s. 337−346-
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Konferensbidrag (refereegranskat)abstract
- Traditional multiprocessor real-time scheduling partitions a task set and applies uniprocessor scheduling on each processor. For architectures where the penalty of migration is low, such as uniform-memory access shared-memory multiprocessors, the non-partitioned method becomes a viable alternative. By allowing a task to resume on another processor than the task was preempted on, some task sets can be scheduled where the partitioned method fails.We address fixed-priority scheduling of periodically arriving tasks on $m$ equally powerful processors having a non-partitioned ready queue. We propose a new priority-assignment scheme for the non-partitioned method. Using an extensive simulation study, we show that the priority-assignment scheme has equivalent performance to the best existing partitioning algorithms, and outperforms existing fixed-priority assignment schemes for the non-partitioned method. We also propose a dispatcher for the non-partitioned method which reduces the number of preemptions to levels below the best partitioning schemes.
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| 8. |
- Andersson, Björn, 1974, et al.
(författare)
-
Global Priority-Driven Aperiodic Scheduling on Multiprocessors
- 2003
-
Ingår i: Proceedings. International Parallel and Distributed Processing Symposium, 2003. - 1530-2075. - 0769519261
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Konferensbidrag (refereegranskat)abstract
- This paper studies multiprocessor scheduling for aperiodic tasks where future arrivals are unknown. A previously proposed priority-driven scheduling algorithm for periodic tasks with migration capability is extended to aperiodic scheduling and is shown to have a capacity bound of 0.5. This bound is close to the best achievable for a priority-driven scheduling algorithm. With an infinite number of processors, no priority-driven scheduling algorithm can perform better. We also propose a simple admission controller which guarantees that admitted tasks meet their deadlines and for many workloads, it admits tasks so that the utilization can be kept above the capacity bound.
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| 9. |
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| 10. |
- Andersson, Björn, 1974, et al.
(författare)
-
Partitioned Aperiodic Scheduling on Multiprocessors
- 2003
-
Ingår i: Proceedings. International Parallel and Distributed Processing Symposium, 2003. - 1530-2075. - 0769519261
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Konferensbidrag (refereegranskat)abstract
- This paper studies multiprocessor scheduling for aperiodic tasks where future arrivals are unknown. We propose an algorithm for tasks without migration capabilities and prove that it has a capacity bound of 0.31. No algorithm for tasks without migration capabilities can have a capacity bound greater than 0.50.
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| 11. |
- Andersson, Björn, 1974, et al.
(författare)
-
Preemptive Multiprocessor Scheduling Anomalies
- 2002
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Ingår i: Proceedings of the IEEE International Parallel and Distributed Processing Symposium, Ft Lauderdale, Florida, April 15–19, 2002. - 0769515738 ; , s. 12-19
-
Konferensbidrag (refereegranskat)abstract
- Preemptive scheduling of periodically arriving tasks on a multiprocessor is considered. We show that many common multiprocessor real-time scheduling algorithms suffer from scheduling anomalies, that is, deadlines are originally met, but a decrease in execution times or an increase in periods of tasks can cause deadlines to be missed. We propose a partitioned multiprocessor fixed-priority scheduling algorithm with the prominent features that (i) it does not suffer from such scheduling anomalies and (ii) if less than 41% of the capacity is used then deadlines are met.
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| 12. |
- Andersson, Björn, 1974, et al.
(författare)
-
Some Insights on Fixed-Priority Preemptive Non-Partitioned Multiprocessor Scheduling
- 2000
-
Ingår i: Proceedings of the 21st IEEE Real-Time Systems Symposium – Work-in-Progress session, Orlando, Florida, November 29, 2000. ; , s. 53-56
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Fixed-priority preemptive scheduling of independent periodictasks on a homogeneous multiprocessor is solved usingone of two different methods based on how tasks are assignedto the processors at run-time. In the partitioned method,all instances of a task are executed on the same processor,where the processor used for each task is determined beforerun-time by a partitioning algorithm. In the non-partitionedmethod, a task is allowed to execute on any processor, evenwhen resuming after having been preempted. Two fundamentalproperties have been shown for the addressed problem. First, the problem of deciding whether a task set isschedulable is NP-hard for both methods. Second, there aretask sets which are schedulable with an optimal priority assignmentwith the non-partitioned method, but are unschedulablewith an optimal partitioning algorithm and conversely.Among the two methods, the non-partitioned method hasreceived considerably less attention, mainly because it is believedto suffer from several scheduling-related shortcomings.The most well-known of these is Dhall’s effect, ascheduling dilemma wherein some task sets may be unschedulableon multiple processors even though they havea low utilization. Another shortcoming is that existingnecessary and sufficient schedulability tests all have exponentialtime complexity, and existing sufficient testshave polynomial complexity but are pessimistic. It hasalso been shown that the RM (rate-monotonic) priorityassignmentscheme is not optimal, and no optimalpriority-assignment schemes with polynomial time complexityhave been found.In this paper, we present an in-depth analysis of the nonpartitionedmethod in terms of its scheduling-related properties.We (i) identify a set of anomalies for preemptivescheduling with migration, which are the first ever reportedin the open research literature, (ii) identify several difficultiesin conveying techniques from uniprocessor schedulingto the multiprocessor case, and (iii) conjecture that there mayexist priority-assignment schemes that can contribute to circumventingDhall’s effect, something that has believed to beinherently impossible with the non-partitioned method.
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| 13. |
- Andersson, Björn, 1974
(författare)
-
Static-priority Scheduling on Multiprocessors
- 2003
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis deals with the problem of scheduling a set of tasks to meet deadlines on a computer with multiple processors. Static-priority scheduling is considered, that is, a task is assigned a priority number that never changes and at every moment the highest-priority tasks that request to be executed are selected for execution. The performance metric used is the capacity that tasks can request without missing a deadline. It is shown that every static-priority algorithm can miss deadlines although close to 50% of the capacity is requested. The new algorithms in this thesis have the following performance. In periodic scheduling, the capacity that can be requested without missing a deadline is: 33% for migrative scheduling and 50% for non-migrative scheduling. In aperiodic scheduling, many performance metrics have been used in previous research. With the aperiodic model used in this thesis, the new algorithms in this thesis have the following performance. The capacity that can be requested without missing a deadline is: 50% for migrative scheduling and 31% for non-migrative scheduling.
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| 14. |
- Andersson, Björn, 1974, et al.
(författare)
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The Utilization Bounds of Partitioned and Pfair Static-Priority Scheduling on Multiprocessors are 50%
- 2003
-
Ingår i: EUROMICRO Conference on Real-Time Systems. - 1068-3070. - 0769519369 ; , s. 33-40
-
Konferensbidrag (refereegranskat)abstract
- This paper studies preemptive static-priority scheduling on multiprocessors. We consider two approaches: global pfair static-priority scheduling and partitioned traditional static-priority scheduling. We prove that if presented algorithms are used and if less than 50% of the capacity is used then all deadlines are met. It is known that no static-priority multiprocessor scheduling algorithm can achieve a utilization bound greater than 50%.
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| 15. |
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| 16. |
- Andersson, Johnn, 1983, et al.
(författare)
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Photovoltaics in Sweden – Success or failure?
- 2021
-
Ingår i: Renewable and Sustainable Energy Reviews. - : Elsevier BV. - 1879-0690 .- 1364-0321. ; 143
-
Tidskriftsartikel (refereegranskat)abstract
- Promoting global energy transitions while stimulating domestic industrialization requires national policymaking that shapes technological innovation towards specific outcomes. Although this is inherently difficult, historical case studies may bring a better understanding of innovation dynamics and thereby guide the design of future policy interventions. The purpose of this paper is to review and analyze the emergence of Swedish photovoltaics technology from a policy perspective. Our main aim is to provide a retrospective account of historical developments, but we also derive more general insights about technological innovation and related policy challenges. The paper departs from an adapted analytical framework based on the technological innovation systems approach. Our review identifies four decades of Swedish research that has largely failed to drive domestic commercialization, the rise and fall of an industry that mainly served international markets, and a rapidly growing domestic market based on imported products. This situation is the result of mismatches and fragmentation among key innovation processes, which have not been addressed by strategic policy interventions. We suggest that policymakers should promote a full range of innovation processes and consider making innovation support subject to a payback mechanism that delivers a return on public investments even if industries and markets emerge abroad. Our study also demonstrates how the technological innovation systems approach can be extended to include the function commercialization and emphasizes the importance of paying attention to the directionality of technological innovation processes.
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| 17. |
- Andersson, Johnn, 1983, et al.
(författare)
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Shaping factors in the emergence of technological innovations: The case of tidal kite technology
- 2018
-
Ingår i: Technological Forecasting and Social Change. - : Elsevier BV. - 0040-1625 .- 1873-5509. ; 132, s. 191-298
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Tidskriftsartikel (refereegranskat)abstract
- The technological innovation systems (TIS) literature offers a detailed and dynamic understanding of factors that enable successful innovation. However, few studies analyze what determines where in space value chain elements are developed as a new technology is diffused on a large scale. The purpose of this paper is to show how the TIS approach can be used to identify and analyze factors that shape spatial trajectories of emerging technologies. It proposes an adapted analytical framework that expands the conventional focus on one-dimensional supporting and blocking factors, to shaping factors that incorporate the spatiality of innovation. The approach is illustrated by examining innovation in tidal kite technology. The analysis finds that a supportive local context in western Sweden during the infancy of tidal kite technology, together with the availability of competent engineers and business development professionals, promoted the formation of locally embedded knowledge and competence. This in turn created a spatial path dependency that made developments gravitate towards Sweden, although the lack of domestic markets has also increasingly driven an expansion of activity to other regions, in particular the UK. Moreover, the analysis shows that shaping, and not only stimulating, the growth of emerging TIS is an important challenge for regional policymakers, and highlights the need for international policy coordination. The paper concludes that analyzing shaping factors in the emergence of new TISs can yield important insights, some of which may be overlooked with a narrow analytical focus on supporting and blocking factors.
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| 18. |
- Andersson, Johnn, 1983, et al.
(författare)
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The outcomes of directionality: Towards a morphology of sociotechnical systems
- 2021
-
Ingår i: Environmental Innovation and Societal Transitions. - : Elsevier BV. - 2210-4224 .- 2210-4232. ; 40, s. 108-131
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Tidskriftsartikel (refereegranskat)abstract
- The sustainability transitions literature departs from the idea that grand challenges such as climate change and rising inequality call for far-reaching changes in sociotechnical systems of production and consumption. This implies a dual interest in the directionality of innovation; some directions of change can be perceived as more desirable, while others may be more plausible due to the path dependent nature of sociotechnical change. The specific characteristics of the potential outcomes of directionality have, however, received little attention. Our aim is therefore to unpack and conceptualize the multidimensional space in which sociotechnical systems may adopt different shapes and configurations. We also provide three illustrative empirical examples where directionality has resulted in systems with different technical, social and spatial characteristics. The ideas put forward in this paper can be seen as a contribution to a morphology of sociotechnical systems and thereby support efforts to investigate or promote specific directions of change.
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| 19. |
- Andrén, Oliver C. J., et al.
(författare)
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Antibiotic-Free Cationic Dendritic Hydrogels as Surgical-Site-Infection-Inhibiting Coatings
- 2019
-
Ingår i: Advanced Healthcare Materials. - : Wiley. - 2192-2640 .- 2192-2659.
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Tidskriftsartikel (refereegranskat)abstract
- A non-toxic hydrolytically fast-degradable antibacterial hydrogel is herein presented to preemptively treat surgical site infections during the first crucial 24 h period without relying on conventional antibiotics. The approach capitalizes on a two-component system that form antibacterial hydrogels within 1 min and consist of i) an amine functional linear-dendritic hybrid based on linear poly(ethylene glycol) and dendritic 2,2-bis(hydroxymethyl)propionic acid, and ii) a di-N-hydroxysuccinimide functional poly(ethylene glycol) cross-linker. Broad spectrum antibacterial effect is achieved by multivalent representation of catatonically charged β-alanine on the dendritic periphery of the linear dendritic component. The hydrogels can be applied readily in an in vivo setting using a two-component syringe delivery system and the mechanical properties can accurately be tuned in the range equivalent to fat tissue and cartilage (G' = 0.5-8 kPa). The antibacterial effect is demonstrated both in vitro toward a range of relevant bacterial strains and in an in vivo mouse model of surgical site infection.
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| 20. |
- Baubeta Fridh, Erik, 1982, et al.
(författare)
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Amputation Rates, Mortality, and Pre-operative Comorbidities in Patients Revascularised for Intermittent Claudication or Critical Limb Ischaemia : A Population Based Study
- 2017
-
Ingår i: European Journal of Vascular and Endovascular Surgery. - : W B SAUNDERS CO LTD. - 1078-5884 .- 1532-2165. ; 54:4, s. 480-486
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The aims of this population based study were to describe mid-to long-term amputation risk, cumulative incidence of death or amputation, and differences in pre-operative comorbidities in patients revascularised for lower limb peripheral artery disease (PAD).Methods: This was an observational cohort study. Data from the Swedish National Quality Registry for Vascular Surgery (Swedvasc) were combined with mandatory national health care registries and patient medical records. All patients who underwent revascularisation in Sweden between May 2008 and May 2013 for intermittent claudication (IC) or critical limb ischaemia (CLI), aged 50 years and older, were identified through the Swedvasc database. The mandatory national health care registries and medical records provided data on comorbidities, mortality, and major amputations.Results: A total of 16,889 patients with PAD (IC, n = 6272; CLI, n = 10,617) were studied. The incidence of amputations in IC patients was 0.4% (range 0.3%-0.5%) per year. Among CLI patients, the amputation rate during the first 6 months following revascularisation was 12.0% (95% CI 11.3-12.6). Thereafter, the incidence declined to approximately 2% per year. The cumulative combined incidence of death or amputation 3 years after revascularisation was 12.9% (95% CI 12.0-13.9) in IC patients and 48.8% (95% CI 47.7-49.8) in CLI patients. Among CLI patients, compared with IC patients, the prevalence of diabetes, ischaemic stroke, heart failure, and atrial fibrillation was approximately doubled and renal failure was nearly tripled, even after age standardisation.Conclusion: The risk of amputation is particularly high during the first 6 months following revascularisation for CLI. IC patients have a benign course in terms of limb loss. Mortality in both IC and CLI patients is substantial. Revascularised CLI patients have different comorbidities from IC patients.
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| 21. |
- Bendelin, Nina, et al.
(författare)
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Patients' experiences of internet-based Acceptance and commitment therapy for chronic pain : a qualitative study
- 2020
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Ingår i: BMC Musculoskeletal Disorders. - : BMC. - 1471-2474. ; 21
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Tidskriftsartikel (refereegranskat)abstract
- Background: Chronic pain is a globally widespread condition with complex clusters of symptoms within a heterogeneous patient group. Internet-delivered Acceptance and Commitment Therapy (IACT) has shown promising results in the treatment of chronic pain. How IACT is experienced by patients is less well known. Qualitative studies of patients' experiences are needed to further understand factors behind both engagement and negative effects. The aim of this study was to explore how IACT was experienced by chronic pain patients who had participated in a controlled trial.Methods: Through an open and exploratory approach this study aimed to investigate how IACT was experienced when delivered as a guided self-help program to persons with chronic pain. Eleven participants were interviewed over telephone after completing IACT.Results: Qualitative analysis based on grounded theory resulted in 2 core categories and 8 subcategories. In treatment: Physical and cognitive restraints, Time and deadline, Therapist contact, and Self-confrontation. After treatment: Attitude to pain, Image of pain, Control or Command, and Acting with pain. Individual differences as well as specific conditions of the treatment may explain variations in how the treatment was approached, experienced and what consequences it led to. Therapist guidance and deadlines for homework play complex roles in relation to autonomy and change.Conclusions: Adjusting treatment content and format based on participants' characteristics, such as expectations, motivation and restraints, might positively affect engagement, autonomy and change. Further research on attrition and negative effects of treatment might clarify what enables chronic pain patients to benefit from IACT.
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| 22. |
- Carlsson, Lena M S, 1957, et al.
(författare)
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Life expectancy after bariatric surgery or usual care in patients with or without baseline type 2 diabetes in Swedish Obese Subjects.
- 2023
-
Ingår i: International journal of obesity (2005). - 1476-5497. ; 47, s. 931-8
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Tidskriftsartikel (refereegranskat)abstract
- To determine life expectancy and causes of death after bariatric surgery in relation to baseline type 2 diabetes (T2D) in the prospective, Swedish Obese Subjects study.The study included 2010 patients with obesity who underwent bariatric surgery and 2037 matched controls, eligible for surgery. The surgery group underwent gastric bypass (n=265), banding (n=376), or vertical banded gastroplasty (n=1369). The control group (n=2037) received usual obesity care. Causes of death were obtained from the Swedish Cause of Death Register, case sheets and autopsy reports, in patients with baseline T2D (n=392 surgery patients/n=305 controls) or non-T2D (n=1609 surgery patients/n=1726 controls) during a median follow-up 26 years.In T2D and non-T2D subgroups, bariatric surgery was associated with increased life expectancy (2.1, 95% confidence interval (95% CI) 0.2-4.0; and 1.6, 0.5-2.7 years, respectively) and reduced overall mortality (adjusted hazard ratio (adjHR)=0.77, 95% CI: 0.61-0.97; and 0.82, 0.72-0.94, respectively), and the treatment benefit was similar (interaction p=0.615). Bariatric surgery was associated with reduced cardiovascular mortality in both subgroups (adjHR=0.65, 95% CI: 0.46-0.91; and 0.70, 0.55-0.88, respectively (interaction p=0.516)).Bariatric surgery is associated with similar reduction of overall and cardiovascular mortality and increased life expectancy regardless of baseline diabetes status.
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| 23. |
- Carlsson, Lena M S, 1957, et al.
(författare)
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Long-term incidence of microvascular disease after bariatric surgery or usual care in patients with obesity, stratified by baseline glycaemic status: a post-hoc analysis of participants from the Swedish Obese Subjects study.
- 2017
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Ingår i: The lancet. Diabetes & endocrinology. - 2213-8595. ; 5:4, s. 271-279
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Tidskriftsartikel (refereegranskat)abstract
- Bariatric surgery is associated with remission of diabetes and prevention of diabetic complications in patients with obesity and type 2 diabetes. Long-term effects of bariatric surgery on microvascular complications in patients with prediabetes are unknown. The aim of this study was to examine the effects of bariatric surgery on incidence of microvascular complications in patients with obesity stratified by baseline glycaemic status.Patients were recruited to the Swedish Obese Subjects (SOS) study between Sept 1, 1987, and Jan 31, 2001. Inclusion criteria were age 37-60 years and BMI of 34 kg/m(2) or greater in men and 38 kg/m(2) or greater in women. Exclusion criteria were identical in surgery and control groups and designed to exclude patients not suitable for surgery. The surgery group (n=2010) underwent gastric bypass (265 [13%]), gastric banding (376 [19%]), or vertical-banded gastroplasty (1369 [68%]). Participants in the control group (n=2037) received usual care. Bodyweight was measured and questionnaires were completed at baseline and at 0·5 years, 1 year, 2 years, 3 years, 4 years, 6 years, 8 years, 10 years, 15 years, and 20 years. Biochemical variables were measured at baseline and at 2 years, 10 years, and 15 years. We categorised participants into subgroups on the basis of baseline glycaemic status (normal [fasting blood glucose concentration <5·0 mmol/L], prediabetes [5·0-6·0 mmol/L], screen-detected diabetes [≥6·1 mmol/L at baseline visit without previous diagnosis], and established diabetes [diagnosis of diabetes before study inclusion]). We obtained data about first incidence of microvascular disease from nationwide registers and about diabetes incidence at study visits at 2 years, 10 years, and 15 years. We did the main analysis by intention to treat, and subgroup analyses after stratification by baseline glycaemic status and by diabetes status at the 15 year follow-up. The SOS study is registered with ClinicalTrials.gov, NCT01479452.4032 of the 4047 participants in the SOS study were included in this analysis. We excluded four patients with suspected type 1 diabetes, and 11 patients with unknown glycaemic status at baseline. At baseline, 2838 patients had normal blood glucose, 591 had prediabetes, 246 had screen-detected diabetes, and 357 had established diabetes. Median follow-up was 19 years (IQR 16-21). We identified 374 incident cases of microvascular disease in the control group and 224 in the surgery group (hazard ratio [HR] 0·56, 95% CI 0·48-0·66; p<0·0001). Interaction between baseline glycaemic status and effect of treatment on incidence of microvascular disease was significant (p=0·0003). Unadjusted HRs were lowest in the subgroup with prediabetes (0·18, 95% CI 0·11-0·30), followed by subgroups with screen-detected diabetes (0·39, 0·24-0·65), established diabetes (0·54, 0·40-0·72), and normoglycaemia (0·63, 0·48-0·81). Surgery was associated with reduced incidence of microvascular events in people with prediabetes regardless of whether they developed diabetes during follow-up.Bariatric surgery was associated with reduced risk of microvascular complications in all subgroups, but the greatest relative risk reduction was observed in patients with prediabetes at baseline. Our results suggest that prediabetes should be treated aggressively to prevent future microvascular events, and effective non-surgical treatments need to be developed for this purpose.US National Institutes of Health, Swedish Research Council, Sahlgrenska University Hospital Regional Agreement on Medical Education and Research, and Swedish Diabetes Foundation.
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| 24. |
- Carlsson, Lena M S, 1957, et al.
(författare)
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Long-term incidence of serious fall-related injuries after bariatric surgery in Swedish obese subjects.
- 2019
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Ingår i: International journal of obesity (2005). - : Springer Science and Business Media LLC. - 1476-5497 .- 0307-0565. ; 43:4, s. 933-937
-
Tidskriftsartikel (refereegranskat)abstract
- Obesity increases risk of falling, but the effect of bariatric surgery on fall-related injuries is unknown. The aim of this study was therefore to study the association between bariatric surgery and long-term incidence of fall-related injuries in the prospective, controlled Swedish Obese Subjects study. At inclusion, body mass index was≥34kg/m2 in men and ≥38kg/m2 in women. The surgery per-protocol group (n=2007) underwent gastric bypass (n=266), banding (n=376), or vertical banded gastroplasty (n=1365), and controls (n=2040) received usual care. At the time of analysis (31 December 2013), median follow-up was 19 years (maximal 26 years). Fall-related injuries requiring hospital treatment were captured using data from the Swedish National Patient Register. During follow-up, there were 617 first-time fall-related injuries in the surgery group and 513 in the control group (adjusted hazard ratio 1.21, 95% CI, 1.07-1.36; P=0.002). The incidence differed between treatment groups (P<0.001, log-rank test) and was higher after gastric bypass than after usual care, banding and vertical banded gastroplasty (adjusted hazard ratio 0.50-0.52, P<0.001 for all three comparisons). In conclusion, gastric bypass surgery was associated with increased risk of serious fall-related injury requiring hospital treatment.
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| 25. |
- Dahlqvist, Ralf, 1973, et al.
(författare)
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Association of calcium with colloidal particles and speciation of calcium in the Kalix and Amazon rivers
- 2004
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Ingår i: Geochimica Et Cosmochimica Acta. - : Elsevier BV. - 0016-7037 .- 1872-9533. ; 68:20, s. 4059-4075
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Tidskriftsartikel (refereegranskat)abstract
- A considerable amount of colloidally bound Ca has been detected in water samples from Amazonian rivers and the Kalix River, a sub-arctic boreal river. Fractionation experiments using several analytical techniques and processing tools were conducted in order to elucidate the matter. Results show that on average 84% of the total Ca concentration is present as free Ca. Particulate, colloidal and complexed Ca constitute the remaining 16%, of which the colloidal fraction is significant. Ultrafiltration experiments show that the colloidal fraction in the sampled Amazonian rivers and the Kalix River range between 1% and 25%. In both the Amazonian and the Kalix rivers the technique of cross-flow ultrafiltration was used to isolate particles and colloids. The difference in concentration measured with ICP-AES and a Ca ion-selective electrode in identical samples was used to define the free Ca concentration and thus indirectly the magnitude of the particulate, colloidal and complexed fractions. Results from the Kalix and Amazonian rivers are in excellent agreement. Furthermore, the results show that the colloidal concentrations of Ca can be greatly overestimated (up to 227%) when conventional analysis and calculation of ultrafiltration data is used due to retention of free Ca ions during the ultrafiltration process. Calculation methods for colloidal matter are presented in this work, using complementary data from ISE analysis. In the Kalix River temporal changes in the fractionation of Ca were studied before, during and after a spring-flood event. Changes in the size distribution of colloidally associated Ca was studied using FlFFF (Flow Field-Flow Fractionation) coupled on-line to a HR ICP-MS. The FlFFF-HR ICP-MS fractograms clearly show the colloidal component of Ca, supporting the ultrafiltration findings. During winter conditions the size distribution of colloidally associated Ca has a concentration maximum at similar to5 to 10 nm in diameter, shifting to smaller sizes (<5 mm) during and after the spring flood. This shift in size distribution follows a change in the river during this period from ironoxyhydroxy colloids being the most important colloidal carrier phase to humic substances during and after the spring flood. WHAM and NICA-Donnan models were used to calculate the amount of colloidally bound Ca. The results similar for both models, show that on average 16% of the Ca may be associated to a colloidal phase, which is in broad agreement with the measurements. Copyright (C) 2004 Elsevier Ltd.
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| 26. |
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| 27. |
- Gromark, Sten, 1951, et al.
(författare)
-
Introduction: Exploring Architectural Validity: Health Promoting Situations of Dwelling, Ageing and Caring
- 2020
-
Ingår i: Architecture for Residential Care and Ageing Communities: Spaces for Dwelling and Healthcare. - New York, NY : Routledge, 2021. : Routledge. ; , s. 1-20
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Architecture for Residential Care and Ageing Communities confronts urgent architectural design challenges within residential innovation, ageing communities and healthcare environments. The increasing and diversified demands on the housing market today call for alterability and adaptability in long term solutions for new integrated ways of residing. Meanwhile, an accentuated ageing society requires new residential ways of living, combining dignity, independence and appropriate care. Concurrently, profound changes in technical conditions for home healthcare require rethinking healing environments. This edited collection explores the dynamics between these integrated architectural and caring developments and intends to envision reconfigured environmental design patterns that can significantly enhance new forms of welfare and ultimately, an improved quality of life. This book identifies, presents, and articulates new qualities in designs, in caring processes, and healing atmospheres, thereby providing operational knowledge developed in close collaboration with academics, actors and stakeholders in architecture, design, and healthcare. This is an ideal read for those interested in health promotive situations of dwelling, ageing and caring.
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| 28. |
- Hedsten, Karin, 1964, et al.
(författare)
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MEMS-based VCSEL beam steering using replicated polymer diffractive lens
- 2008
-
Ingår i: Sensors and Actuators, A: Physical. - : Elsevier BV. - 0924-4247 .- 1873-3069. ; 142:1, s. 336-345
-
Tidskriftsartikel (refereegranskat)abstract
- Abstract. This paper describes a fully integrated micro-optical system, in which dynamic angular control of the beam from a VCSEL (vertical cavity surface emitting laser) is realized by laterally moving a collimat¬ing diffractive lens in the light path. The lens is mounted on a translatable silicon stage, which consists of a frame with an opening for the light to traverse the lens and electro-statically driven comb actuators, by which the lateral movement is achieved. Devices implementing both 1D and 2D scanning have been fabricated and evaluated. Integration of the lens onto the translatable silicon stage is done using a newly developed fabrication process based on hot embossing of an amorphous fluorocarbon polymer. This fabrication process relies on a reversed-order protocol, where the structuring of the optical element precedes the silicon microstructuring. Assembly and packaging of the VCSEL-MOEMS system, using LTCC (low temperature cofired ceramic) technique, is also demonstrated. Optical evaluation of the system and beam steering function shows significant beam deflection for a relatively low driving voltage (~70 V).
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| 29. |
- Hellsmark, Hans, 1974, et al.
(författare)
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Teknologiska innovationssystem inom energiområdet: En praktisk vägledning till identifiering av systemsvagheter som motiverar särskilda politiska åtaganden
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna rapport är att illustrera hur ett praktiskt inriktat ramverk, tekno- logiska innovationssystem (TIS), kan användas av analytiker och beslutsfattare vid departement och myndigheter för att analysera strategiskt viktiga teknikområden ?????????????????????????????????????????????????????????????????????????????I rapporten analyseras fem TIS centrerade kring havsbaserad vindkraft, marin energi, ????????????????????????????????????????????????????????????????????????????????????? systemsvagheter som bromsar områdets vidare utveckling, vilka som kan åtgärdas av systemets aktörer och vilka som motiverar särskilda politiska åtaganden. Rapporten utgör därmed ett underlag för att formulera åtgärder för att åstadkomma ökad innova- tion, teknikspridning och industrialisering inom ovan nämnda teknikområden.Studien har även möjliggjort en jämförande analys av likheter och skillnader ???????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????????? mellan områdena – de är starka respektive svaga av olika orsaker. Detta visar att ???????????????????????????????????????????????????????????????????????Samtidigt har områdena gemensamma drag. Systemets aktörer, där även politiska ???????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????- skapsnätverk. Men de har varit sämre på att skapa tidiga nischmarknader som ger utrymme för fortsatt lärande och kostnadsreduktion. Sådana nischer kan ibland skapas av marknadens aktörer, men ofta krävs politiska styrmedel. De behövs för att investeringar i kunskapsutveckling ska kunna nyttiggöras och för att en bred industriell utveckling inom nya områden skall göras möjlig i Sverige.Vidare presenteras lärdomar kring vad en aktiv teknikpolitik innebär. Två huvud- ??????????????????????????????????????????????????????????????????????????????- hällsbygget och därför bör vara ett politikområde bland många samt att den skarpa ??????????????????????????????????????????????????????????????????????????????- ?????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????? olika faser av innovationssystemets utveckling.För att lyckas med en aktiv teknikpolitik behövs en hög grad av koordinering ??????????????????????????????????????????????????????????????????????? teknikområden så att ”rätt” typ av åtgärder kan sättas in vid ”rätt” tidpunkt av ”rätt” aktör. TIS-ramverket lyfts här fram som en metod för att skapa ett sådant underlag. Slutligen presenteras en metod för projektbedömningar som syftar till att stötta handläggare i utvärderingar av projekt inom nya teknikområden.Rapporten i sin helhet riktar sig särskilt till beslutsfattare och handläggare vid myndigheter, departement och politiker, men även andra organisationer och indi- vider med intresse av att högt ställda klimatmål ska kunna nås samtidigt som en positiv näringslivsutveckling möjliggörs.
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| 30. |
- Jacobson, Peter, 1962, et al.
(författare)
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9p21.3 Coronary Artery Disease Locus Identifies Patients With Treatment Benefit From Bariatric Surgery in the Nonrandomized Prospective Controlled Swedish Obese Subjects Study.
- 2020
-
Ingår i: Circulation. Genomic and precision medicine. - 2574-8300. ; 13:5, s. 460-465
-
Tidskriftsartikel (refereegranskat)abstract
- Sequence variation at chromosome 9p21.3 accounts for 20% of myocardial infarctions (MIs) in several populations. Whereas the risk conferred by the 9p21.3 locus appears to act independently of traditional risk factors, studies suggest that the association between 9p21.3 and MI is modified by glucose homeostasis and lifestyle. We examined if the 9p21.3 variant rs1333049, along with the previously identified predictor fasting insulin, modifies the preventive effect of bariatric surgery on MI incidence.rs1333049 was genotyped in 1852 patients treated by bariatric surgery and 1803 controls given usual care in the SOS study (Swedish Obese Subjects). MI incidence was determined using national registers. Median follow-up was 21 years (interquartile range 18-24 years).Overall, 366 MIs occurred during follow-up. Among rs1333049 risk-allele carriers (CC+GC), the incidence of MI was reduced in the surgery group compared with the control group (hazard ratio=0.72 [95% CI, 0.57-0.92], P=0.008). By contrast, noncarriers (GG) showed no significant differences in MI incidence between the treatment groups (hazard ratio=1.28 [0.86-1.90], P=0.227; interaction between treatment and the risk-allele P=0.016). In addition, carriers with higher fasting insulin (above the median [17 mmol/L]) experienced significantly higher MI incidence than carriers with lower fasting insulin (hazard ratio=0.58 [0.42-0.78], P<0.001, interaction P=0.031).In the SOS cohort, patients with the chromosome 9p21.3 rs1333049 risk allele together with high fasting insulin levels benefitted from bariatric surgery in terms of reduced incidence of MI. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01479452.
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| 31. |
- Jakobsson, S, et al.
(författare)
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Combustion engine optimization: A multiobjective approach
- 2010
-
Ingår i: Optimization & Engineering. - : Springer Science and Business Media LLC. - 1389-4420 .- 1573-2924. ; 11:4, s. 533-554
-
Tidskriftsartikel (refereegranskat)abstract
- To simulate the physical and chemical processes inside combustion engines is possible by appropriate software and high performance computers. For combustion engines a good design is such that it combines a low fuel consumption with low emissions of soot and nitrogen oxides. These are however partly conflicting requirements. In this paper we approach this problem in a multi-criteria setting which has the advantage that it is possible to estimate the trade off between the different objectives and the decision of the optimal solution is postponed until all possibilities and limitations are known. The optimization algorithm is based on surrogate models and is here applied to optimize the design of a diesel combustion engine.
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| 32. |
- Jaldell, Henrik, 1968-, et al.
(författare)
-
Are national injury prevention and research efforts matching the distribution of injuries across sectors?
- 2015
-
Ingår i: Injury Prevention. - : BMJ Publishing Group Ltd. - 1353-8047 .- 1475-5785. ; 21:e1, s. e113-e115
-
Tidskriftsartikel (refereegranskat)abstract
- In 2011, 88% of all unintentional injury fatalities occurred in home and leisure environments in Sweden, while transportation fatalities accounted for 10% and work/school injuries for 2%. The corresponding proportions among non-fatal injuries were 75, 12 and 13%, respectively. However, 83% of the national governmental expenditure on unintentional injury prevention in 2011 was allocated to transportation safety, 7% to home and leisure, and 10% to the work sector including schools. Likewise, around 85% of the governmental research budget aimed for unintentional injury research was allocated to the transportation sector, 9% to home and leisure environments, and 6% to the work and school sector. Our results reveal a striking lack of correspondence between problem profile and governmental countermeasures.
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| 33. |
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| 34. |
- Karlsson, Linn, 1974-
(författare)
-
Chronic Pain and Exercise : Studies on pain intensity, biochemistry, adherence and attitudes
- 2017
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Chronic pain is common in western countries and entails considerable consequences for the afflicted individuals as well as for the society. Furthermore, chronic pain is complex including an advanced interplay between biological-, psychological- and social aspects. Treatment of chronic pain attempts to decrease pain intensity and increase physical-, psychological- and social functioning. However, the treatment of chronic pain is still not optimized. Different types of physical activity and exercise (PA&E) are commonly applied as non-pharmacological treatment strategies for chronic pain, but the most efficient type and dose of PA&E are unclear. In addition, adherence to prescribed PA&E is often troublesome, which further complicates the application of PA&E as treatment for chronic pain.The aim of this thesis is to increase the knowledge about PA&E as treatment for chronic pain regarding pain intensity, biochemical substances, adherence and attitudes.The findings of this thesis were that a long-term, home-based PA&E intervention comprising strength exercises as well as stretch exercises decreased pain intensity and increased function in women with chronic neck- and shoulder pain. Using microdialysis technique, differences in pain modulatory biochemical substances were found, before the intervention, in painful trapezius muscle compared to pain-free trapezius muscle. In addition, alterations in pain modulatory substances in painful trapezius muscle after the intervention were found, which possibly could imply peripheral physiological effects of PA&E. Furthermore, psychological factors could be associated to the effects of and adherence to the PA&E intervention. An intention to be physically active were expressed by patients with chronic pain, but a discordance between the intention and PA&E-behaviour were evident, even though the PA&E were experienced as valuable.In conclusion, this thesis strengthens the importance of PA&E as treatment for chronic pain. Especially, this thesis increases the knowledge about; possible peripheral pain inhibitory effects after long-term exercise; how psychological factors might affect the results of PA&E; and also about important behavioural aspects that might affect adherence to prescribed PA&E. This thesis highlights the need of more research on physiological pain inhibitory effects of long-term PA&E in chronic pain. Furthermore, improved methods for ensured adherence to prescribed PA&E are necessary in order to optimize the effect of PA&E as treatment for chronic pain.
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| 35. |
- Kristensson, Felipe M., et al.
(författare)
-
Effects of Bariatric Surgery in Early- and Adult-Onset Obesity in the Prospective Controlled Swedish Obese Subjects Study.
- 2020
-
Ingår i: Diabetes care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 43:4, s. 860-866
-
Tidskriftsartikel (refereegranskat)abstract
- Bariatric surgery is an effective treatment for obesity, but it is unknown if outcomes differ between adults with early- versus adult-onset obesity. We investigated how obesity status at 20 years of age affects outcomes after bariatric surgery later in life.The Swedish Obese Subjects study is a prospective matched study performed at 25 surgical departments and 480 primary health care centers. Participants aged 37-60 years with BMI ≥34 kg/m2 (men) or ≥38 kg/m2 (women) were recruited between 1987 and 2001; 2,007 participants received bariatric surgery and 2,040 usual care. Self-reported body weight at 20 years of age was used to stratify patients into subgroups with normal BMI (<25 kg/m2), overweight (BMI 25-29.9 kg/m2), or obesity (BMI ≥30 kg/m2). Body weight, energy intake, and type 2 diabetes status were examined over 10 years, and incidence of cardiovascular and microvascular disease was determined over up to 26 years using data from health registers.There were small but statistically significant differences in reduction of body weight among the subgroups after bariatric surgery (interaction P = 0.032), with the largest reductions among those with obesity aged 20 years. Bariatric surgery increased type 2 diabetes remission (odds ratios 4.51, 4.90, and 5.58 in subgroups with normal BMI, overweight, or obesity at 20 years of age, respectively; interaction P = 0.951), reduced type 2 diabetes incidence (odds ratios 0.15, 0.13, and 0.15, respectively; interaction P = 0.972), and reduced microvascular complications independent of obesity status at 20 years of age (interaction P = 0.650). The association between bariatric surgery and cardiovascular disease was similar in the subgroups (interaction P = 0.674). Surgical complications were similar in the subgroups.The treatment benefits of bariatric surgery in adults are similar regardless of obesity status at 20 years of age.
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| 36. |
- Kristensson, Felipe M., et al.
(författare)
-
Long-term effects of bariatric surgery in patients with obesity and chromosome 16 p11.2 microdeletion
- 2017
-
Ingår i: Surgery for Obesity and Related Diseases. - : Elsevier BV. - 1550-7289. ; 13:8, s. 1321-1326
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Chromosome 16 p11.2 microdeletion is associated with early-onset obesity. Information is limited about the effect of bariatric surgery in patients with genetic obesity. Objective: To examine the effects of bariatric surgery in obese patients with chromosome 16 p11.2 microdeletion. Methods: The Swedish Obese Subjects study is a prospective study with 2010 participants receiving bariatric surgery. DNA was available for 1843 participants. Multiplex ligation-dependent probe amplification was used to identify 16 p11.2 microdeletion carriers. Follow-up time was 10 years. In carriers and noncarriers, follow-up rate was 86% and 82%, respectively, at 10 years. Results: Nine carriers of the chromosome 16 p11.2 microdeletion (9/1843, .49%) were found. At baseline, most risk factors were similar; however, carriers had higher body mass index (BMI), insulin levels, and systolic blood pressure compared to noncarriers. At the 1 -year examination, the percent excess BMI lost (%EBMIL) in carriers and noncarriers was 71.9 and 62.2, respectively; P = .031 (37.9 and 30.6 kg). This was followed by partial weight regain in both groups, and after 10 years %BBMIL was 25.5 and 41.5 (15.7 and 21.3 kg), respectively (P = .377). Changes in risk factors were similar in the carriers and noncarriers. Two carriers who had type 2 diabetes at baseline were both in remission at 2 -year follow-up but relapsed at 10 -year follow-up. Perceived health status was similar in carriers and noncarriers during follow-up (overall P = .198). Conclusions: Despite a small sample size, our results indicate that bariatric surgery is a treatment option for obese patients with chromosome 16 p11.2 microdeletion. (Surg Obes Relat Dis 2017;13:1321-1326.) (C) 2017 American Society for Metabolic and Bariatric Surgery. All rights reserved.
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| 37. |
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| 38. |
- Lena, Carlsson, et al.
(författare)
-
Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study.
- 2020
-
Ingår i: The New England journal of medicine. - 1533-4406. ; 383:16, s. 1535-1543
-
Tidskriftsartikel (refereegranskat)abstract
- Obesity shortens life expectancy. Bariatric surgery is known to reduce the long-term relative risk of death, but its effect on life expectancy is unclear.We used the Gompertz proportional hazards regression model to compare mortality and life expectancy among patients treated with either bariatric surgery (surgery group) or usual obesity care (control group) in the prospective, controlled Swedish Obese Subjects (SOS) study and participants in the SOS reference study (reference cohort), a random sample from the general population.In total, 2007 and 2040 patients were included in the surgery group and the control group, respectively, and 1135 participants were included in the reference cohort. At the time of the analysis (December 31, 2018), the median duration of follow-up for mortality was 24 years (interquartile range, 22 to 27) in the surgery group and 22 years (interquartile range, 21 to 27) in the control group; data on mortality were available for 99.9% of patients in the study. In the SOS reference cohort, the median duration of follow-up was 20 years (interquartile range, 19 to 21), and data on mortality were available for 100% of participants. In total, 457 patients (22.8%) in the surgery group and 539 patients (26.4%) in the control group died (hazard ratio, 0.77; 95% confidence interval [CI], 0.68 to 0.87; P<0.001). The corresponding hazard ratio was 0.70 (95% CI, 0.57 to 0.85) for death from cardiovascular disease and 0.77 (95% CI, 0.61 to 0.96) for death from cancer. The adjusted median life expectancy in the surgery group was 3.0 years (95% CI, 1.8 to 4.2) longer than in the control group but 5.5 years shorter than in the general population. The 90-day postoperative mortality was 0.2%, and 2.9% of the patients in the surgery group underwent repeat surgery.Among patients with obesity, bariatric surgery was associated with longer life expectancy than usual obesity care. Mortality remained higher in both groups than in the general population. (Funded by the Swedish Research Council and others; SOS ClinicalTrials.gov number, NCT01479452.).
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| 39. |
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| 40. |
- Lindskog, Mats, 1974-
(författare)
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Computational analyses of biological sequences -applications to antibody-based proteomics and gene family characterization
- 2005
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Following the completion of the human genome sequence, post-genomic efforts have shifted the focus towards the analysis of the encoded proteome. Several different systematic proteomics approaches have emerged, for instance, antibody-based proteomics initiatives, where antibodies are used to functionally explore the human proteome. One such effort is HPR (the Swedish Human Proteome Resource), where affinity-purified polyclonal antibodies are generated and subsequently used for protein expression and localization studies in normal and diseased tissues. The antibodies are directed towards protein fragments, PrESTs (Protein Epitope Signature Tags), which are selected based on criteria favourable in subsequent laboratory procedures.This thesis describes the development of novel software (Bishop) to facilitate the selection of proper protein fragments, as well as ensuring a high-throughput processing of selected target proteins. The majority of proteins were successfully processed by this approach, however, the design strategy resulted in a number ofnfall-outs. These proteins comprised alternative splice variants, as well as proteins exhibiting high sequence similarities to other human proteins. Alternative strategies were developed for processing of these proteins. The strategy for handling of alternative splice variants included the development of additional software and was validated by comparing the immunohistochemical staining patterns obtained with antibodies generated towards the same target protein. Processing of high sequence similarity proteins was enabled by assembling human proteins into clusters according to their pairwise sequence identities. Each cluster was represented by a single PrEST located in the region of the highest sequence similarity among all cluster members, thereby representing the entire cluster. This strategy was validated by identification of all proteins within a cluster using antibodies directed to such cluster specific PrESTs using Western blot analysis. In addition, the PrEST design success rates for more than 4,000 genes were evaluated.Several genomes other than human have been finished, currently more than 300 genomes are fully sequenced. Following the release of the tree model organism black cottonwood (Populus trichocarpa), a bioinformatic analysis identified unknown cellulose synthases (CesAs), and revealed a total of 18 CesA family members. These genes are thought to have arisen from several rounds of genome duplication. This number is significantly higher than previous studies performed in other plant genomes, which comprise only ten CesA family members in those genomes. Moreover, identification of corresponding orthologous ESTs belonging to the closely related hybrid aspen (P. tremula x tremuloides) for two pairs of CesAs suggest that they are actively transcribed. This indicates that a number of paralogs have preserved their functionalities following extensive genome duplication events in the tree’s evolutionary history.
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| 41. |
- Mashad Nemati, Hossein, 1980, et al.
(författare)
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Varactor-Based Dynamic Load Modulation of RF PAs
- 2011
-
Ingår i: European Microwave Conference, Manchester, Workshop "RF PA Efficiency Enhancement Techniques".
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 42. |
- Messina, David, 1974-, et al.
(författare)
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Discovery of novel protein families in metagenomic samples
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Despite the steady rise in gene sequence information, there is a persistent, significant fraction of genes which do not match any previously known sequence. These genes are called ORFans, and metagenomic samples, where DNA is extracted from a mixed population of unknown and often uncultivable species, are a rich source of ORFans. Viral infections cause significant morbidity and mortality, and identifying ORFan viral gene families from human metagenomic samples represents a route to understanding molecular processes that affect human health. Few methods exist for metagenomic gene-finding, and most of them rely on sequence similarity, which cannot be used to detect ORFans. Furthermore, nonsimilarity-based methods are hard to apply to the complex mixture of short, higherror-rate sequence fragments which are typical of metagenomic projects. Here we present an approach to detect ORFan protein families in short-read data, and apply it to 937 Mbp (megabase pairs) of sequence from 17 virus-enriched libraries made from human nasopharyngeal aspirates, serum, feces, and cerebrospinal fluid samples. After isolating approximately 450 putative ORFan families from clusters of sequence contigs, we applied RNAcode, a gene finder developed for use on high-quality genome sequences, and calibrated it for errorprone short sequence reads. Additional predictive measures such as sequence complexity and length were then used to rank and filter candidates into a high-quality set of 32 putative novel gene families, only two of which show significant similarity to known genes.
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| 43. |
- Nicholls, Ian A., et al.
(författare)
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Rational design of biomimetic molecularly imprinted materials : theoretical and computational strategies for guiding nanoscale structured polymer development
- 2011
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Ingår i: Analytical and Bioanalytical Chemistry. - : Springer Science and Business Media LLC. - 1618-2642 .- 1618-2650. ; 400:6, s. 1771-1786
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Forskningsöversikt (refereegranskat)abstract
- In principle, molecularly imprinted polymer science and technology provides a means for ready access to nano-structured polymeric materials of predetermined selectivity. The versatility of the technique has brought it to the attention of many working with the development of nanomaterials with biological or biomimetic properties for use as therapeutics or in medical devices. Nonetheless, the further evolution of the field necessitates the development of robust predictive tools capable of handling the complexity of molecular imprinting systems. The rapid growth in computer power and software over the past decade has opened new possibilities for simulating aspects of the complex molecular imprinting process. We present here a survey of the current status of the use of in silico-based approaches to aspects of molecular imprinting. Finally, we highlight areas where ongoing and future efforts should yield information critical to our understanding of the underlying mechanisms sufficient to permit the rational design of molecularly imprinted polymers.
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| 44. |
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| 45. |
- Olsson, Louise, 1974, et al.
(författare)
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A kinetic study of oxygen adsorption/desorption and NO oxidation over Pt/Al2O3 catalysts
- 1999
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Ingår i: Journal of Physical Chemistry B Materials. - : American Chemical Society (ACS). - 1089-5647 .- 1520-6106 .- 1520-5207. ; 103:47, s. 10433-10439
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Tidskriftsartikel (refereegranskat)abstract
- Laboratory tests and kinetic modeling were carried out in order to provide kinetic input data to a systematic investigation of the mechanism of nitrogen oxides (NO,) storage in catalysts used for lean-burn engines. In particular, we present a kinetic model of the NO oxidation to NO2 over a Pt/Al2O3 model catalyst for the temperature range 250-450 degrees C. Since the oxygen behavior at atmospheric pressure is critical for such a model, we have also studied the adsorption/desorption of oxygen by temperature-programmed desorption (TPD) experiments. The experiments show that oxygen starts to desorb at about 300 degrees C. Furthermore, the NO oxidation was studied in a temperature ramp with NO and oxygen in the gas feed. The data from this experiment and the above-determined values for the oxygen adsorption/desorption were used to construct a kinetic model for the NO oxidation. Finally, the model was validated with some transient experiments with either NO or NO2 and different oxygen concentrations in the gas feed. We found a good agreement between these experiments and the model.
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| 46. |
- Rundqvist, Robert, 1974, et al.
(författare)
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Simulation of Spray Painting in Automotive Industry
- 2010
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Ingår i: Numerical Mathematics and Advanced Applications 2009 (Proceedings of ENUMATH 2009, the 8th European Conference on Numerical Mathematics and Advanced Applications, Uppsala, July 2009). - Berlin, Heidelberg : Springer Berlin Heidelberg. ; Part 2, s. 769-777
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Konferensbidrag (refereegranskat)
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| 47. |
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| 48. |
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| 49. |
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| 50. |
- Stålfelt, Frans, 1995, et al.
(författare)
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Can particle counting replace conventional surveillance for airborne bacterial contamination assessments? A systematic review using narrative synthesis
- 2023
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Ingår i: AMERICAN JOURNAL OF INFECTION CONTROL. - : Elsevier Inc.. - 0196-6553 .- 1527-3296. ; 51:12, s. 1417-1424
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Forskningsöversikt (refereegranskat)abstract
- Background: Bacterial airborne contamination in the operating room during surgery indicates an increased risk for surgical site infection. The conventional surveillance method for bacteria in the air is by air sampling, plating, and counting of colony-forming units (CFU). Particle counting measures particles in the air, typically in sizes of 1-20 mu m, and has been suggested as an alternative to CFU measurements. The primary aim was to investigate the correlation between the number of airborne CFU and particles during surgery. The secondary aim was to explore whether different ventilation settings influence the correlation between CFU and particles. Methods: The databases Cochrane, Embase, and Medline were searched for relevant publications. Due to the heterogeneity of the data, meta-analysis was not possible and a narrative analysis was performed instead. Results: The review included 11 studies. Two of the studies (n = 2) reported strong correlation between particles and CFU (Rp = 0.76 and Rc = 0.74). The remaining studies observed moderate correlation (n = 3), low correlation (n = 3), or no correlation (n = 3). Based on the primary results from this study, ventilation attribution to distinguish the correlation between particles and CFU had no or little contribution. Conclusions: Due to the lack of convincing evidence of correlation and lack of high-quality studies performing measurements in a standardized way, the studies could not provide the necessary evidence that show that particle counting could be used as a substitution for conventional air bacterial assessment. Further studies are warranted to strengthen the conclusion.
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