| 1. |
- Grönbeck-Linden, Ingela, 1955, et al.
(författare)
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Factors Affecting Older Persons’ Ability to Manage Oral Hygiene: A Qualitative Study
- 2017
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Ingår i: JDR Clinical & Translational Research. - : SAGE Publications. - 2380-0844 .- 2380-0852. ; 2:3, s. 223-32
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Tidskriftsartikel (refereegranskat)abstract
- A great challenge for the dental service is to support the growing group of elderly people with preserving good oral health throughout their lives. Limitations in the ability to manage oral hygiene and an increased number of risk factors are often reflected by poor oral health. Thus, the need for individualized support and oral health procedures based on the older person’s condition is significant. Deficiencies in the motor skills needed to manage oral hygiene are well known, but other factors that affect the ability are not well studied. The aim of the present study was to identify factors that may affect an elderly person’s ability to perform oral hygiene self-care, which is the first step to develop a more comprehensive “oral hygiene ability index.” The design of the study was qualitative. Data were collected from 4 focus group interviews with a total of 23 participants. Three of the groups consisted of dental hygienists, occupational therapists, and assistant nurses, all working with elderly persons. The fourth group was made up of elderly people (72–89 years). Content analysis was used to analyze the data. The latent content was formulated into the core category, “oral hygiene—a complex activity.” Three categories emerged: “psychological,” “environmental,” and “functional” dimensions. The psychological dimension described attitude/motivation, emotions, and cognitive factors. The environmental dimension included practical conditions and social context. The functional dimension dealt with bodily and oral function as well as the senses. In conclusion, self-care with respect to oral hygiene is a complex activity for elderly persons and includes a large number of factors. These factors should be taken into consideration when developing a future oral hygiene ability index.
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| 2. |
- Leveau, Per, et al.
(författare)
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Percutaneous cholecystostomy: a bridge to surgery or definite management of acute cholecystitis in high-risk patients?
- 2008
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 43:5, s. 593-596
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Cholecystectomy is the standard treatment for acute cholecystitis, but in high-risk patients with serious comorbidity and in patients of advanced age there is substantial morbidity and mortality associated with the intervention. In these selected patients, percutaneous cholecystostomy (PCS) is an alternative mode of management. The aim of the present study was to evaluate the outcome of PCS in selected patients with acute cholecystitis. MATERIAL AND METHODS: Thirty-five patients, representing 0.6% of all acute cholecystitis patients managed during the period 1994-2003, were subjected to PCS. Patients' charts were reviewed retrospectively for age, gender, comorbidity, hospital stay, procedure, complications and final outcome, including requirement of additional interventions. RESULTS: PCS was considered successful in 34/35 patients, 26 of whom responded within 3 days. Two patients required additional cholecystectomy 3 days and 20 months, respectively, after the PCS procedure. Two patients underwent endoscopic retrograde cholangiopancreatography (ERCP) and one patient underwent rotation lithotripsy. Four patients suffered recurrent biliary complaints after the acute episode of cholecystitis, while the only serious procedure-related complication was bile leakage from the gallbladder in one patient, which necessitated cholecystectomy. CONCLUSIONS: PCS is a comparatively safe and efficient procedure in the treatment of acute cholecystitis in high-risk patients with serious comorbidity and in elderly patients, contraindicating the general anaesthesia required for laparoscopic or open cholecystectomy.
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| 3. |
- Andersson Cederholm, Erika, et al.
(författare)
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”Samverkan är ju hela tiden, överallt” : samverkan som gränsobjekt i akademin
- 2024
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Ingår i: Nordisk tidsskrift for utdanning og praksis. - : Cappelen Damm Akademisk, Nordic Open Scholarly Publishing (NOASP). - 2535-7697. ; 14:1, s. 29-43
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Tidskriftsartikel (refereegranskat)abstract
- Hur och i vilken omfattning högre lärosäten (universitet och högskolor) i Sverige samverkar med samhället har debatterats i media såväl som i forskningen. Denna artikel belyser den formaliseringsprocess som skett i kölvattnet av nya regleringar och politiska krav på samverkan. I studien analyseras officiella dokument och intervjuer med universitetsanställda vid två svenska lärosäten. Analysen fokuserar på begreppet samverkan som ett gränsobjekt och belyser den mångtydighet som kännetecknar den rådande formaliseringen. Strävan efter definitioner och operationaliseringar av samverkan ger upphov till många specifika och lokala tolkningar; av begreppet som sådant, hur samverkanskompetens ska definieras och hur samverkans genomslag ska mätas. I artikeln diskuteras nackdelarna med formaliseringsprocesser som drivs för långt och som kan bidra till att samverkan förvandlas till ett självändamål.
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| 4. |
- Andersson, Ingela, 1963-, et al.
(författare)
-
Elevers formande av arbetsplatsförlagt lärande i svensk gymnasial lärlingsutbildning : [How students in Swedish upper secondary apprenticeship education contribute to form their education in relation to work-based learning]
- 2022
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Ingår i: Nordic Journal of Vocational Education and Training. - : Linkoping University Electronic Press. - 2242-458X. ; 12:1, s. 1-24
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Tidskriftsartikel (refereegranskat)abstract
- The article examines how students in Swedish upper secondary apprenticeship education contribute to the shaping of their education through their choices and actions in relation to work-based learning. Activity theory and the notion of interacting activity systems was used to emphasise the students’ perspective as active subjects. Data was collected through observations and interviews with 15 students in their second year of an apprenticeship. An initial qualitative content analysis revealed a pattern of actions that related to both school and work. The result of this analysis was further elaborated with activity theoretical concepts. Thereby dominating rules/norms and tools they made use of, contributed to identifying three potential objects for students’ actions: grades in vocational subjects, development of vocational skills, and inclusion in the workplace community. Depending on what objects the students held as superior and subordinate different outcomes could be achieved – an upper secondary vocational degree, development of vocational skills, and/or being employed while studying. One object did not necessarily exclude the others. It is concluded that the multiple expectations from students, school, and workplaces that coexist in relation to work-based learning need to be continuously communicated among all participants to strengthen the students’ possibility to achieve their desired educational outcome.
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| 5. |
- Andersson, Ingela, 1963, et al.
(författare)
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Elevers formande av arbetsplatsförlagt lärande i svensk gymnasial lärlingsutbildning : How students in Swedish upper secondary apprenticeship education contribute to form their education in relation to work-based learning
- 2022
-
Ingår i: Nordic Journal of Vocational Education and Training. - 2242-458X. ; 12:1, s. 1-24
-
Tidskriftsartikel (refereegranskat)abstract
- The article examines how students in Swedish upper secondary apprenticeship education contribute to the shaping of their education through their choices and actions in relation to work-based learning. Activity theory and the notion of interacting activity systems was used to emphasize the students’ perspective as active subjects. Data was collected through observations and interviews with 15 students in their second year of an apprenticeship. An initial qualitative content analysis revealed a pattern of actions that related to both school and work. The result of this analysis was further elaborated with activity theoretical concepts. Thereby dominating rules/norms and tools they made use of, contributed to identifying three potential objects for students’ actions: grades in vocational subjects, development of vocational skills, and inclusion in the workplace community. Depending on what objects the students held as superior and subordinate different outcomes could be achieved – an upper secondary vocational degree, development of vocational skills, and/or being employed while studying. One object did not necessarily exclude the others. It is concluded that the multiple expectations from students, school, and workplaces that coexist in relation to work-based learning need to be continuously communicated among all participants to strengthen the students’ possibility to achieve their desired educational outcome.
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| 6. |
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| 7. |
- Andersson, Ingela, 1963, et al.
(författare)
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Formation of Apprenticeships in the Swedish Education System: Different Stakeholder Perspectives
- 2015
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Ingår i: International Journal for Research in Vocational Education and Training. - 2197-8646. ; 2:1, s. 3-24
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Tidskriftsartikel (refereegranskat)abstract
- The article explores the major features of the Swedish Government’s new initiative - a school based Upper Secondary Apprenticeship model. The analyses are guided by activity theory. The analysed texts are part of the parliamentary reform-making process of the 2011 Upper Secondary School reform. The analyses unfold how the Government, the Swedish Trade Union Confederation (LO), and the Confederation of Swedish Enterprise (SN) construct Upper Secondary Apprenticeship as an activity in the 21st century. The conclusion highlights how three traditional aspects of Swedish initial vocational education and training (IVET) collide in the formation of Upper Secondary Apprenticeship – a curriculum of labour market based apprenticeships, a curriculum of school based IVET, and ill-defined curriculums of school based apprenticeships. The emerging Upper Secondary Apprenticeship curriculum foreshadows multifaceted educational trajectories where the learning targets, and not the responsibility for the student’s learning are displaced from the school to the workplace setting.
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| 8. |
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| 9. |
- Andersson, Ingela, et al.
(författare)
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Impact of the European Water Framework Directive on local-level water management : Case study Oxunda Catchment, Sweden
- 2012
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Ingår i: Land use policy. - : Elsevier. - 0264-8377 .- 1873-5754. ; 29:1, s. 73-82
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Tidskriftsartikel (refereegranskat)abstract
- The Water Framework Directive (WFD) of the European Union provides a common framework for water policy that focuses on holistic and integrated water management in river basins. In many member states, implementation of the WFD has shifted the main responsibility for local water issues from the municipal level to the regional or supra-regional levels. In this study, we investigated how the implementation of the WFD has influenced local-level water management including the interpretation of the new environmental quality standards. Specifically, we considered Sweden, which has traditionally had relatively strong governance at the municipal level. Because a sufficient amount of time has now passed for evaluation of WFD-related effects on operational water handling, we interviewed individuals directly involved in water planning and land use planning at the municipal level in one sub catchment in the Northern Baltic Sea River Basin District of Sweden, as well as representatives for superior levels and associations. Despite divergent views regarding the priority of water issues in physical planning among the local-level planners interviewed, they had all participated in successful inter-municipal pre-WFD collaboration projects. Although such collaborations could help increase the understanding and acceptance of WFD-related goals and costs, as well as facilitate conflict solving, as shown in the Oxunda Catchment, they have not gained much attention in the WFD implementation process. Additionally, physical planners have generally been reluctant to accept new environmental quality standards resulting from WFD implementation, in part because they lack precise definitions, but also because they could challenge the municipal routine of weighing various objectives against each other. Furthermore, despite WFD-related increases in ambition levels, lack of resource improvements at the municipal level were identified as potential problems by local environmental planners.
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| 10. |
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| 11. |
- Andersson, Ingela, 1963
(författare)
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Operating between Rationalities: How Swedish Vocational Teachers and Workplace Tutors Negotiate and Create Students' Training Schemes
- 2015
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Ingår i: Crossing Boundaries in Vocational Education and Training: Innovative Concepts for the 21st Century. Eds. Michael Gessler and Larissa Freund. 2-4 sept 2015 Bremen. Conference Proceedings.. - 1861-6828. ; 2015 Evaluate Europe Handbook Series:Volume 6, s. 34-38
-
Konferensbidrag (refereegranskat)abstract
- The paper investigates a changed educational practice where Swedish vocational teachers have become responsible for planning and evaluating students’ learning in workplaces. Four vocational teachers were shadowed during 12 workplace visits. Deploying the concept of boundary crossing the findings foreshadow an evolving educational activity where vocational teachers collaborate with workplace tutors to evaluate and reconstruct students training schemes. The analysis shows how vocational teachers use their teacher skills, and their familiarity with the target occupation to identify and establish work tasks for the students to engage in at the workplace.
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| 12. |
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| 13. |
- Andersson, Ingela, et al.
(författare)
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Saving the Baltic Sea, the Inland Waters of Its Drainage Basin, or Both? : Spatial Perspectives on Reducing P-Loads in Eastern Sweden
- 2014
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Ingår i: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 43:7, s. 914-925
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Tidskriftsartikel (refereegranskat)abstract
- Nutrient loads from inland sources to the Baltic Sea and adjacent inland waters need to be reduced in order to prevent eutrophication and meet requirements of the European Water Framework Directive (WFD) and the Baltic Sea Action Plan (BSAP). We here investigate the spatial implications of using different possible criteria for reducing water-borne phosphorous (P) loads in the Northern Baltic Sea River Basin District (NBS-RBD) in Sweden. Results show that most catchments that have a high degree of internal eutrophication do not express high export of P from their outlets. Furthermore, due to lake retention, lake catchments with high P-loads per agricultural area (which is potentially of concern for the WFD) did not considerably contribute to the P-loading of the Baltic Sea. Spatially uniform water quality goals may, therefore, not be effective in NBS-RBD, emphasizing more generally the need for regional adaptation of WFD and BSAP-related goals.
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| 14. |
- Andersson, Ingela, 1963
(författare)
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Skolbaserad gymnasial lärlingsutbildning . Delanalys av hur utbildningsformen formuleras och kontextualiseras i samtida policy och styrdokument. NORDYRK Juni 2013
- 2013
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Ingår i: NORDYRK Juni 2013 Karlstads Universitet.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- 2011 införs lärlingsutbildning i den sammanhållna svenska gymnasieskolan som en av två vägar till en yrkesexamen. Traditionellt har gymnasial yrkesförberedande utbildning varit i huvudsak skolförlagd, vilket innebär att vi inte har några långtgående traditioner av arbetsplatsförlagd utbildning i gymnasieskolans regi. Mitt forskningsintresse handlar om hur lärlingsutbildningen tar form i policy och styrdokument, i skolans organisation och i genomförandets praktiker – i mötet mellan skolan och arbetslivet. I detta papper presenteras datakonstruktion och en delanalys av hur lärlingsutbildningen formuleras och kontextualiseras i samtida policy- och styrdokument. Analysen är en innehållsanalys i två steg (Krippendorf 2004; Graneheim och Lundman 2004). I ett försök att visa hur jag gått tillväga med analysen lyfter jag fram två teman där lärlingsutbildningen kontextualiseras i texterna och där den förhandlas i dialogen inom textkedjan. Jag har ännu inte lagt ett teoretiskt perspektiv på dessa data, vilket betyder att resultaten är på en beskrivande nivå nära texten. Resultatet visar att lärlingsutbildningen i dessa policysammanhang formuleras och kontextualiseras som grundläggande yrkesutbildning i gymnasieskolans regi, vilken till minst hälften förläggs i arbetslivet. I spänningsfältet där utbildningens innehåll och form förhandlas visar delanalysen att utbildningen är under utformning i det politiska sammanhanget, som en av två vägar till en gymnasial yrkesexamen. En sammanfattande slutsats är att den svenska lärlingsutbildningen som är under utformning i de politiska sammanhangen är komplex då den inte har befästa traditioner att bygga på, vilket sannolikt också påverkar hur utbildningen tar form i olika skolors verksamheter i förhållande till lokala förutsättningar och behov.
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| 15. |
- Andersson, Ingela, 1963
(författare)
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Workplace Learning for School-Based Apprenticeships: Tripartite Conversations as a Boundary-Crossing Tool
- 2018
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Ingår i: Integration of Vocational Education and Training Experiences. - Singapore : Springer. - 1871-3041. ; , s. 259-278
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter examines how a vocational education and training activity, the tripartite conversation, is shaped in the context of the Swedish upper secondary apprenticeship education. Learning in school and in a workplace is often emphasised as complementary. Research that draws on activity theory emphasises the development of shared spaces to support integration of learning across these sites. In this chapter the tripartite conversation is investigated as a tool intended to support integration of experiences across school and workplace. The focus of this study was the following question: What does the tripartite conversation indicate about what the parties try to achieve with regard to students’ learning? Field studies were conducted in three upper secondary schools in 2014. Sixteen tripartite conversations between vocational teacher, workplace tutor and student have been analysed. Activity theory and the concepts of tensions and contradictions have formed the analytical framework. The tripartite conversation is identified as a boundary-crossing tool to plan and negotiate workplace learning paths. The findings show that students were expected to develop knowledge, skills and abilities to handle daily work assignments and complex work situations in the workplace. These goals were sometimes hard to achieve due to uncertainties among participants about the learning objectives, norms and rules that guided the students’ learning in the work place. It is concluded that integration of experiences across sites can be supported when workplace learning is collaboratively planned and evaluated from the perspectives of school and workplace respectively. © 2018, Springer Nature Singapore Pte Ltd.
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| 16. |
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| 17. |
- Andersson, Martina, et al.
(författare)
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Erfarenhet av att bedöma äldre personers problem i livets slutskede : en fokusgruppsstudie ur ett sjuksköterskeperspektiv
- 2020
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Rapport (populärvet., debatt m.m.)abstract
- Andelen äldre personer i Sverige ökar och en del äldre personer drabbas av en eller flera kroniska sjukdomar. Allt fler personer önskar att vårdas hemma vid livets slut och kan då vara i behov av allmän palliativ vård. Vid palliativ vård i livets slutskede är det en eftersträvan att lindra lidande och förbättra livskvaliteten genom att tidigt uppmärksamma och lindra personers fysiska, psykiska, sociala och existentiella problem. Äldre personer i livets slutskede har ofta flera komplexa problem som påverkar varandra. För att lindra lidande behöver sjuksköterskor kunna bedöma och tolka olika problem som äldre personer kan uppleva i livets slutskede. Syftet med studien var att beskriva sjuksköterskors erfarenhet av att bedöma problem som äldre personer besväras av i livets slutskede inom kommunal hemsjukvård. En kvalitativ metod har använts. Data samlades in med fyra fokusgruppsintervjuer. Totalt deltog 13 sjuksköterskor verksamma inom hemsjukvård från tre olika kommuner i studien. Data analyserades med Kvalitativ innehållsanalys. I resultatet framkom ett övergripande tema: strävan efter kontinuitet för att lära känna personen genom återkommande hembesök underlättar bedömning av problem som behöver tillgodoses i livets slutskede samt kategorierna; att bygga en relation underlättar bedömningen, att samtala för att erhålla information, att observera kroppsspråket skapar en bild och att ta del av andras iakttagelser som stöd. Resultatet visade att relationen till den äldre var viktig för att bedöma den äldres problem och att sjuksköterskor till stor del förlitade sig på sin kliniska blick vid bedömningen. Vidare framkom att sjuksköterskorna sällan använde sig av skattningsinstrument, vilket de uttryckte en önskan att bli bättre på. Slutsatsen är att en ökad användning av skattningsinstrument skulle kunna förenkla bedömning av problem hos äldre personer som sjuksköterskorna inte sedan tidigare har någon relation till. Detta skulle kunna skapa en känsla av trygghet för sjuksköterskorna och stärka dem i deras professionella roll. Användningen av skattingsinstrument skulle kunna öka kvaliteten på den allmänna palliativa vården som utförs i kommunal hemsjukvård. För att sjuksköterskorna ska få stöd i att öka användningen av skattningsinstrument har organisationen en viktig roll för att skapa rutiner och se till att etablerade arbetsformer utvecklas.
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| 18. |
- Andersson, Martina, et al.
(författare)
-
Erfarenhet av att bedöma äldre personers problem i livets slutskede : en fokusgruppsstudie ur ett sjuksköterskeperspektiv
- 2020
-
Bok (övrigt vetenskapligt/konstnärligt)abstract
- Andelen äldre personer i Sverige ökar och en del äldre personer drabbas av en eller flera kroniska sjukdomar. Allt fler personer önskar att vårdas hemma vid livets slut och kan då vara i behov av allmän palliativ vård. Vid palliativ vård i livets slutskede är det en eftersträvan att lindra lidande och förbättra livskvaliteten genom att tidigt uppmärksamma och lindra personers fysiska, psykiska, sociala och existentiella problem. Äldre personer i livets slutskede har ofta flera komplexa problem som påverkar varandra. För att lindra lidande behöver sjuksköterskor kunna bedöma och tolka olika problem som äldre personer kan uppleva i livets slutskede. Syftet med studien var att beskriva sjuksköterskors erfarenhet av att bedöma problem som äldre personer besväras av i livets slutskede inom kommunal hemsjukvård. En kvalitativ metod har använts. Data samlades in med fyra fokusgruppsintervjuer. Totalt deltog 13 sjuksköterskor verksamma inom hemsjukvård från tre olika kommuner i studien. Data analyserades med Kvalitativ innehållsanalys. I resultatet framkom ett övergripande tema: strävan efter kontinuitet för att lära känna personen genom återkommande hembesök underlättar bedömning av problem som behöver tillgodoses i livets slutskede samt kategorierna; att bygga en relation underlättar bedömningen, att samtala för att erhålla information, att observera kroppsspråket skapar en bild och att ta del av andras iakttagelser som stöd. Resultatet visade att relationen till den äldre var viktig för att bedöma den äldres problem och att sjuksköterskor till stor del förlitade sig på sin kliniska blick vid bedömningen. Vidare framkom att sjuksköterskorna sällan använde sig av skattningsinstrument, vilket de uttryckte en önskan att bli bättre på. Slutsatsen är att en ökad användning av skattningsinstrument skulle kunna förenkla bedömning av problem hos äldre personer som sjuksköterskorna inte sedan tidigare har någon relation till. Detta skulle kunna skapa en känsla av trygghet för sjuksköterskorna och stärka dem i deras professionella roll. Användningen av skattingsinstrument skulle kunna öka kvaliteten på den allmänna palliativa vården som utförs i kommunal hemsjukvård. För att sjuksköterskorna ska få stöd i att öka användningen av skattningsinstrument har organisationen en viktig roll för att skapa rutiner och se till att etablerade arbetsformer utvecklas.
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| 19. |
- Andersson, Per, et al.
(författare)
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Characteristics of patients with acute myocardial infarction contacting primary healthcare before hospitalisation: a cross-sectional study
- 2018
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Ingår i: BMC Family Practice. - : BMC. - 1471-2296. ; 19
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The characteristics of patients with on-going myocardial infarction (MI) contacting the primary healthcare (PHC) centre before hospitalisation are not well known. Prompt diagnosis is crucial in patients with MI, but many patients delay seeking medical care. The aims of this study was to 1) describe background characteristics, symptoms, actions and delay times in patients contacting the PHC before hospitalisation when falling ill with an acute MI, 2) compare those patients with acute MI patients not contacting the PHC, and 3) explore factors associated with a PHC contact in acute MI patients. Methods: This was a cross-sectional multicentre study, enrolling consecutive patients with MI within 24 hours of admission to hospital from Nov 2012 until Feb 2014. Results: A total of 688 patients with MI, 519 men and 169 women, were included; the mean age was 66 +/- 11 years. One in five people contacted PHC instead of the recommended emergency medical services (EMS), and 94% of these patients experienced cardinal symptoms of an acute MI; i.e., chest pain, and/or radiating pain in the arms, and/or cold sweat. Median delay time from symptom-onset-to-decision-to-seek-care was 2:15 hours in PHC patients and 0:40 hours in non-PHC patients (pamp;lt;0.01). The probability of utilising the PHC before hospitalisation was associated with fluctuating symptoms (OR 1.74), pain intensity (OR 0.90) symptoms during off-hours (OR 0.42), study hospital (OR 3.49 and 2.52, respectively, for two of the county hospitals) and a final STEMI diagnosis (OR 0.58). Conclusions: Ambulance services are still underutilized in acute MI patients. A substantial part of the patients contacts their primary healthcare centre before they are diagnosed with MI, although experiencing cardinal symptoms such as chest pain. There is need for better knowledge in the population about symptoms of MI and adequate pathways to qualified care. Knowledge and awareness amongst primary healthcare professionals on the occurrence of MI patients is imperative.
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| 20. |
- Andersson, Peter, et al.
(författare)
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Hemma hos Charlotte Berlin
- 2016
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Ingår i: Den högst originella fröken Charlotte Berlin. - 9789163906381 ; , s. 176-187
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Bokkapitel (populärvet., debatt m.m.)
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| 21. |
- Andersson, Patrik, et al.
(författare)
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Toxicity with LXR agonists – Problem solving activities for mechanistic understanding
- 2012
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Ingår i: Toxicology Letters. - Shannon : Elsevier. - 0378-4274 .- 1879-3169. ; 211:Suppl. (S), s. S39-S39
-
Tidskriftsartikel (refereegranskat)abstract
- Several lines of evidence points toward the potential positive effects of LXR (Liver X Receptor) modulators for effective and safe therapy of cardiovascular diseases (CVDs). LXR is a dimeric nuclear hormone receptor that exists as a combination of RXR and one of two subtypes LXR alpha or beta, which act as cholesterol sensors. LXR alpha is highly expressed in the liver, intestine and adipose tissue while LXR beta is ubiquitously expressed. Activation of LXR up-regulates several genes involved in reverse cholesterol transport (RCT), including ABC transporters. This results in increased efflux of cholesterol from macrophages in atherosclerotic vascular lesions to the circulation and further on to other tissues to ultimately be excreted into the faeces. These effects together with systemic and local anti-inflammatory properties of LXR modulation are likely to contribute to decreased atherosclerosis. The positive effects of LXR activation on RCT and cholesterol balance must be obtained without negative lipid effects, since LXR also activates lipogenic genes. Other types of toxicity and approaches to better understand the mechanism(s) behind these will be presented. Copyright © 2012 Published by Elsevier Ireland Ltd.
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| 22. |
- Andersson-Sköld, Yvonne, et al.
(författare)
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A framework for assessing urban greenery's effects and valuing its ecosystem services
- 2018
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Ingår i: Journal of Environmental Management. - : Academic Press. - 0301-4797 .- 1095-8630. ; 205, s. 274-285
-
Tidskriftsartikel (refereegranskat)abstract
- Ongoing urban exploitation is increasing pressure to transform urban green spaces, while there is increasing awareness that greenery provides a range of important benefits to city residents. In efforts to help resolve associated problems we have developed a framework for integrated assessments of ecosystem service (ES) benefits and values provided by urban greenery, based on the ecosystem service cascade model. The aim is to provide a method for assessing the contribution to, and valuing, multiple ES provided by urban greenery that can be readily applied in routine planning processes. The framework is unique as it recognizes that an urban greenery comprises several components and functions that can contribute to multiple ecosystem services in one or more ways via different functional traits (e.g. foliage characteristics) for which readily measured indicators have been identified. The framework consists of five steps including compilation of an inventory of indicator; application of effectivity factors to rate indicators' effectiveness; estimation of effects; estimation of benefits for each ES; estimation of the total ES value of the ecosystem. The framework was applied to assess ecosystem services provided by trees, shrubs, herbs, birds, and bees, in green areas spanning an urban gradient in Gothenburg, Sweden. Estimates of perceived values of ecosystem services were obtained from interviews with the public and workshop activities with civil servants. The framework is systematic and transparent at all stages and appears to have potential utility in the existing spatial planning processes.
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| 23. |
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| 24. |
- Andersson, Ulrika, 1977, et al.
(författare)
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I gratistidningsland
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Kartläggning av den svenska gratistidningsmarknaden, med avseende på tidningstyper, tidningsinnehåll och läsning av gratistidningar.
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| 25. |
- Andersson, Ulrika, 1977-, et al.
(författare)
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I gratistidningsland.
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)
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| 26. |
- Andersson, Ulrika, 1977, et al.
(författare)
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Public Interest or Self-Interest? How journalism attracts future journalists
- 2015
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Ingår i: Journal of Media Practice. - 1468-2753. ; 16:2
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Tidskriftsartikel (refereegranskat)abstract
- Since the 1990s, Western society and its media have veered towards increased market orientation. In this process, values of individualisation and self-interest have emerged as important patterns. Research has shown that media professionals have become slightly more commercially oriented over time, although public interest remains the most important factor when the duties of journalism are fulfilled. What can be said, however, about the journalists of the future? This study aims at analysing why students from different generations are attracted by journalism as profession. It is done by drawing empirical support from two questionnaires completed by first-year students in Sweden in 1994 and 2012. The analysis deals with approximately 160 journalism students and takes as its point of departure the theoretical framework of commercialisation and generational belonging. The main result shows that journalism students have moved slightly towards an increased market orientation but similarly also towards an increased focus on public interest. The paper discusses how this change may affect journalism.
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| 27. |
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| 28. |
- Andersson, Viveka, et al.
(författare)
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Benefits of using the Brief Pain Inventory in patients with cancer pain: an intervention study conducted in Swedish hospitals
- 2020
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Ingår i: Supportive Care in Cancer. - : Springer Science and Business Media LLC. - 0941-4355 .- 1433-7339. ; 28, s. 3721-3729
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose The prevalence of cancer pain is too high. There is a need for improvement of pain management in cancer care. The aim of this study was to explore whether the use of the multidimensional pain assessment questionnaire Brief Pain Inventory (BPI) could improve pain relief in hospitalized patients with cancer. Methods A controlled intervention study was performed at two hospitals in western Sweden, 264 patients were included, 132 formed a control group and 132 an intervention group. All participants completed the BPI and the Edmonton Symptom Assessment Scale (ESAS) at baseline. Only the researcher had access to questionnaires from the control group. The completed forms from the intervention group were presented to the patients’ care team. A follow-up took place after 2–5 days when patients in both groups rated the scales a second time. Results In the intervention group, significant differences in all measured items of the BPI were found at follow-up compared with baseline. Symptoms rated with the ESAS also decreased significantly, except shortness of breath. At follow-up, a significant increase in regular use of paracetamol, anti-neuropathic pain drugs and opioids was found, as well as elevated doses of fixed-schedule opioids. In the control group, differences between baseline and follow-up were significant regarding average pain and worst pain over the past 24 h. Conclusion Presenting the patient-reported BPI to the care team helped them to focus on patients’ pain, identify pain mechanisms and adjust analgesics accordingly. A possible explanation for the results is changes in the medication prescribed.
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| 29. |
- Andersson, Viveka, et al.
(författare)
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Pain and pain management in children and adolescents receiving hospital care: a cross-sectional study from Sweden
- 2022
-
Ingår i: BMC Pediatrics. - : Springer Science and Business Media LLC. - 1471-2431. ; 22:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background Pain is a common symptom in children receiving hospital care. Adequate pain management in paediatric patients is of the utmost importance. Few studies have investigated children's own experiences of pain during hospitalization. Aim To describe the prevalence of pain, self-reported pain intensity at rest and during movement, pain management and compliance with pain treatment guidelines in children and adolescents receiving hospital care. Furthermore, to examine self-reported statements about pain relief and how often staff asked about pain. Methods A quantitative, cross-sectional study with descriptive statistics as the data analysis method was conducted at a county hospital in western Sweden. Sixty-nine children/adolescents aged 6-18 years who had experienced pain during their hospital stay were included. A structured, verbally administered questionnaire was used to obtain pain reports. The participants were also asked what they considered alleviated pain and how often they told staff about pain. Patient demographics, prescribed analgesics and documentation of pain rating were obtained from medical records. Results Fifty children/adolescents (72%) experienced moderate to severe pain in the previous 24 hours. At the time of the interview 36% reported moderate to severe pain at rest and 58% during movement. Seven participants (10%) reported severe pain both at rest and during movement. About one-third were on a regular multimodal analgesic regimen and 28% had used a validated pain rating scale. Thirty children/adolescents (43%) reported that they had experienced procedural pain in addition to their underlying pain condition. Most of the children/adolescents (74%) reported that analgesics provided pain relief. Forty (58%) stated that various non-pharmacological methods were helpful. Conclusions Despite evidence-based guidelines, half of the children/adolescents experienced moderate to severe pain, highlighting the need for improvement. Pain levels should be assessed both at rest and during movement. Response to treatment should be evaluated to prevent undertreatment of pain. Compliance with guidelines and professional communication are of the utmost importance for pain management in children/adolescents. Non-pharmacological methods are a valuable part of a pain management strategy. This study shows that it is important to evaluate and improve pain care also outside specialised tertiary clinics.
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| 30. |
- Andersson, Viveka, et al.
(författare)
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Pain and pain management in hospitalized patients before and after an intervention
- 2017
-
Ingår i: Scandinavian Journal of Pain. - : Walter de Gruyter GmbH. - 1877-8860 .- 1877-8879. ; 15, s. 22-29
-
Tidskriftsartikel (refereegranskat)abstract
- Background and aim Studies have shown that pain is common among hospitalized patients and that there is a lack of compliance with pain management guidelines. Improving pain management does not only involve developing new drugs or technology; even more important is an effective organisation that utilises existing expertise. The aim of this study was to investigate whether pain in hospitalized patients can be reduced by implementing evidence-based pain management guidelines, providing education for staff and an organisation that includes pain responsibility nurses. Methods A cross-sectional study was carried out between 2009 and 2010 at two hospitals in southwest Sweden, comprising a baseline survey followed by an intervention. The study involved 306 patients, who answered questions about pain intensity at rest and while moving, disturbed sleep due to pain and whether they had used a pain rating scale while in hospital. Medical records were scrutinised for analgesic prescriptions. An intervention then took place, involving implementation of evidence-based guidelines, staff education and the introduction of pain responsibility nurses. A follow-up survey was carried out in 2012, in which 293 patients answered the same questions and their medical records were also reviewed. The baseline results were then compared with those of the follow-up survey. Results When compared with the baseline survey, the follow-up survey revealed significant differences in the use of validated pain rating instruments as well as the prescription of more appropriate analgesics. Prescription of paracetamol increased significantly in the follow-up survey; 56% of the patients were prescribed paracetamol on a regular basis, compared with 42% at baseline. There was also a significant increase in the use of strong opioids, from 38% at baseline to 55% at follow-up. Prescriptions of weak opioids decreased from 16% at baseline to 4% at follow-up. No significant differences were observed in patient pain levels in the follow-up survey. At baseline, 29% of the patients reported moderate to severe pain at rest (NRS 4–10) and at follow-up that figure was 24% (NRS 4–10). In both surveys, 41% reported moderate to severe pain (NRS 5–10) during movement. Thirty-nine percent reported disturbed sleep at night at both baseline and follow-up. Conclusions This study demonstrates that evidence-based guidelines made accessible to all staff as a pocket size booklet and on the intranet, in combination with staff education, pain responsibility nurses who informed other staff on their own wards, improved the prescription of analgesics in the hospitals studied. In order to achieve a noticeable effect for patients, i.e., reduced pain levels, an intervention containing more components than those employed in the present study is required. Implications Nurses and physicians need greater knowledge about the importance of pain rating. A vital part of pain management at hospitals is continuous evaluation of treatment outcomes to prevent severe pain and disturbed sleep. The complexity of pain and pain management requires commitment, time and knowledge on the part of healthcare staff. Multi-professional pain teams that support ward staff in pain management are necessary in order to reduce suffering and unnecessary pain in hospitalized patients. © 2016 Scandinavian Association for the Study of Pain
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| 31. |
- Askelöf, U., et al.
(författare)
-
Wait a minute? : An observational cohort study comparing iron stores in healthy Swedish infants at 4 months of age after 10-, 60- and 180-second umbilical cord clamping
- 2017
-
Ingår i: BMJ Open. - : BMJ Publishing Group. - 2044-6055. ; 7:12
-
Tidskriftsartikel (refereegranskat)abstract
- Background and objective: Umbilical cord blood (UCB) is a valuable stem cell source used for transplantation. Immediate umbilical cord (UC) clamping is widely practised, but delayed UC clamping is increasingly advocated to reduce possible infant anaemia. The aim of this study was to investigate an intermediate UC clamping time point and to evaluate iron status at the age of 4 months in infants who had the UC clamped after 60 s and compare the results with immediate and late UC clamping. Design: Prospective observational study with two historical controls. Setting: A university hospital in Stockholm, Sweden, and a county hospital in Halland, Sweden. Methods: Iron status was assessed at 4 months in 200 prospectively recruited term infants whose UC was clamped 60 s after birth. The newborn baby was held below the uterine level for the first 30 s before placing the infant on the mother's abdomen for additional 30 s. The results were compared with data from a previously conducted randomised controlled trial including infants subjected to UC clamping at ≤10 s (n=200) or ≥180 s (n=200) after delivery. Results: After adjustment for age differences at the time of follow-up, serum ferritin concentrations were 77, 103 and 114 μg/L in the 10, 60 and 180 s groups, respectively. The adjusted ferritin concentration was significantly higher in the 60 s group compared with the 10 s group (P=0.002), while the difference between the 60 and 180 s groups was not significant (P=0.29). Conclusion: In this study of healthy term infants, 60 s UC clamping with 30 s lowering of the baby below the uterine level resulted in higher serum ferritin concentrations at 4 months compared with 10 s UC clamping. The results suggest that delaying the UC clamping for 60 s reduces the risk for iron deficiency. © 2017 Article author(s).
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| 32. |
- Berglund, Ingrid, 1954, et al.
(författare)
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Vocational teacher students’ critical reflections in site-based education
- 2020
-
Ingår i: International Journal of Training Research. - : Informa UK Limited. - 1448-0220 .- 2204-0544. ; 18:1, s. 22-36
-
Tidskriftsartikel (refereegranskat)abstract
- Critical reflection is an essential element in the professional teacher’s practice. This article investigates vocational teacher education (VTE) students´ ability to reflect when engaged in site-based education and considers how arrangements in vocational teacher education enable or constrain this ability. The study was conducted at one Swedish university, where 78 VTE students’ written self-evaluation reports from three practicum courses were analyzed on the basis of the concept of critical reflection and the theory of practice architectures. The findings emphasize the value of a strong relationship between the learning at university and in the teaching workplace, and the progression of critical reflection throughout the education. These findings support the conclusion that practice architectures that improve VTE students’ ability to critical reflection need to include tasks that focuse on both reflection and on bridging the contexts of research-based and experience-based knowledge and practice.
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| 33. |
- Bergman, Hilde-Marléne, et al.
(författare)
-
Quantitative mass spectrometry imaging of small-molecule neurotransmitters in rat brain tissue sections using nanospray desorption electrospray ionization
- 2016
-
Ingår i: The Analyst. - : Royal Society of Chemistry (RSC). - 0003-2654 .- 1364-5528. ; 141:12, s. 3686-3695
-
Tidskriftsartikel (refereegranskat)abstract
- Small molecule neurotransmitters are essential for the function of the nervous system, and neurotransmitter imbalances are often connected to neurological disorders. The ability to quantify such imbalances is important to provide insights into the biochemical mechanisms underlying the disorder. This proof-of-principle study presents online quantification of small molecule neurotransmitters, specifically acetylcholine, γ-aminobutyric acid (GABA) and glutamate, in rat brain tissue sections using nanospray desorption electrospray ionization (nano-DESI) mass spectrometry imaging. By incorporating deuterated internal standards in the nano-DESI solvent we show identification, accurate mapping, and quantification of these small neurotransmitters in rat brain tissue without introducing any additional sample preparation steps. We find that GABA is about twice as abundant in the medial septum-diagonal band complex (MSDB) as in the cortex, while glutamate is about twice as abundant in the cortex as compared to the MSDB. The study shows that nano-DESI is well suited for imaging of small molecule neurotransmitters in health and disease.
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| 34. |
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| 35. |
- Björklund, Patrik, et al.
(författare)
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Västerås slott : Slott och borgar
- 2000
-
Rapport (populärvet., debatt m.m.)abstract
- En majoritet av dagens byggnadsuppgifter gäller att hantera det redan byggda. När vi står inför situationen att restaurera en befintlig byggnad är det viktigt att förstå olika tidsperioders stilideal liksom byggnadsteknik och material. Först då kan vi göra en väl avvägd analys, som tar tillvara och utvecklar de kvaliteter som byggnaderna själva besitter. Därför är utbildningen upplagd som ett växelspel mellan föreläsningar, seminarier, exkursioner och en för året vald studieuppgift.Slott och borgar har varit läsårets tema. Vi har valt att arbeta med Västerås och Örebro slott - två ganska bortglömda Vasaslott som är väl värda att lyfta fram. Särskilt har vi studerat de senaste 300 årens förändringar, som inte tidigare ägnats lika stora forskarmöda som medelitden och Vasatiden. I dessa två exempel finns en provkarta på estetiska, praktiska och tekniska ingrepp från Carl Hårlemans tid och fram till idag.Studierna har således omfattat både gestaltning, funktion och byggnadsteknik. Avsikten är att visa på kvaliteter i de omvandlingar och restaureringar som skett, men också att peka på problem och analysera olika möjligheter inför framtiden. Arbetet har skett i samarbete med Statens fastighetsverk och är tänkt att utgöra ett underlag till vårdprogram och framtida restaureringsinsatser.
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| 36. |
- Castedal, Maria, 1964, et al.
(författare)
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Long-term follow-up of living liver donors.
- 2010
-
Ingår i: Transplantation proceedings. - : Elsevier BV. - 1873-2623 .- 0041-1345. ; 42:10, s. 4449-54
-
Tidskriftsartikel (refereegranskat)abstract
- At our center living donor liver transplantation (LDLT) represents 4% of all transplantations. The aim of this cross-sectional study was to clarify the current well-being of the donors, their experiences of being a donor, as well as the regenerative capacity of the liver.
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| 37. |
- Duncan, Kyle D., et al.
(författare)
-
A pneumatically assisted nanospray desorption electrospray ionization source for increased solvent versatility and enhanced metabolite detection from tissue
- 2017
-
Ingår i: The Analyst. - : ROYAL SOC CHEMISTRY. - 0003-2654 .- 1364-5528. ; 142:18, s. 3424-3431
-
Tidskriftsartikel (refereegranskat)abstract
- Nanospray desorption electrospray ionization (nano-DESI) has been established as a powerful technique for mass spectrometry imaging (MSI) of biomolecules from tissue samples. The direct liquid extraction of analytes from a surface at ambient pressure negates the need for significant sample preparation or matrix application. Although many recent studies have applied nano-DESI to new and exciting applications, there has not been much work in the development and improvement of the nano-DESI source. Here, we incorporate a nebulizer to replace the self-aspirating secondary capillary in the conventional nano-DESI setup, and characterize the device by use of rat kidney tissue sections. We find that the pneumatically assisted nano-DESI device offers improved sensitivity for metabolite species by 1-3 orders of magnitude through more complete desolvation and reduced ionization suppression. Further, the pneumatically assisted nano-DESI device reduces the dependence on probe-to-surface distance and enables sampling and imaging using pure water as the nano-DESI solvent. This provides exclusive detection and imaging of many highly polar endogenous species. Overall, the developed pneumatically assisted nano-DESI device provides more versatile solvent selection and an increased sensitivity for metabolites, which generates ion images of higher contrast - allowing for more intricate studies of metabolite distribution.
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| 38. |
- Duncan, Kyle D., et al.
(författare)
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Oversampling To Improve Spatial Resolution for Liquid Extraction Mass Spectrometry Imaging
- 2018
-
Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 90:4, s. 2451-2455
-
Tidskriftsartikel (refereegranskat)abstract
- Liquid extraction mass spectrometry imaging (MSI) experiments provide users with direct analysis of biological surfaces with minimal sample preparation. Until now, much of the effort to increase spatial resolution for MSI with liquid extraction techniques has focused on reducing the size of the sampling area. However, this can be experimentally challenging. Here, we present oversampling as a simple alternative to increase the spatial resolution using nanospray desorption electrospray ionization (nano-DESI) MSI. By imaging partial rat spinal cord tissue sections, two major concerns with oversampling are addressed: whether endogenous molecules are significantly depleted from repeated sampling events and whether analytes are redistributed as a result of oversampling. In depth examination of ion images for representative analytes show that depletion and redistribution do not affect analyte localization in the tissue sample. Nano-DESI MSI experiments using three times oversampling provided higher spatial resolution, allowing the observation of features not visible with undersampling. Although proper care must be taken to ensure that oversampling will work in specific applications, we envision oversampling as a simple approach to increase image quality for liquid extraction MSI techniques.
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| 39. |
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| 40. |
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| 41. |
- Elgqvist, Jörgen, 1963, et al.
(författare)
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Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35 F(ab')2.
- 2006
-
Ingår i: International journal of radiation oncology, biology, physics. - : Elsevier BV. - 1879-355X .- 0360-3016. ; 66:4, s. 1228-37
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To elucidate the therapeutic efficacy of alpha-radioimmunotherapy of ovarian cancer in mice. This study: (i) estimated the minimum required activity (MRA), giving a reasonable high therapeutic efficacy; and (ii) calculated the specific energy to tumor cell nuclei and the metastatic cure probability (MCP) using various assumptions regarding monoclonal-antibody (mAb) distribution in measured tumors. The study was performed using the alpha-particle emitter Astatine-211 (211At) labeled to the mAb MX35 F(ab')2. METHODS AND MATERIALS: Animals were inoculated intraperitoneally with approximately 1 x 10(7) cells of the cell line NIH:OVCAR-3. Four weeks later animals were treated with 25, 50, 100, or 200 kBq 211At-MX35 F(ab')2 (n = 74). Another group of animals was treated with a nonspecific mAb: 100 kBq 211At-Rituximab F(ab')2 (n = 18). Eight weeks after treatment the animals were sacrificed and presence of macro- and microscopic tumors and ascites was determined. An MCP model was developed and compared with the experimentally determined tumor-free fraction (TFF). RESULTS: When treatment was given 4 weeks after cell inoculation, the TFFs were 25%, 22%, 50%, and 61% after treatment with 25, 50, 100, or 200 kBq (211)At-MX35 F(ab')2, respectively, the specific energy to irradiated cell nuclei varying between approximately 2 and approximately 400 Gy. CONCLUSION: As a significant increase in the therapeutic efficacy was observed between the activity levels of 50 and 100 kBq (TFF increase from 22% to 50%), the conclusion was that the MRA is approximately 100 kBq (211)At-MX35 F(ab')2. MCP was most consistent with the TFF when assuming a diffusion depth of 30 mum of the mAbs in the tumors.
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| 42. |
- Elgqvist, Jörgen, 1963, et al.
(författare)
-
Alpha-radioimmunotherapy of intraperitoneally growing OVCAR-3 tumors of variable dimensions: Outcome related to measured tumor size and mean absorbed dose.
- 2006
-
Ingår i: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - 0161-5505 .- 2159-662X. ; 47:8, s. 1342-50
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of this work was to (a) investigate the efficacy of radioimmunotherapy using 211At-MX35 F(ab')2 or 211At-Rituximab F(ab')2 (nonspecific antibody) against differently advanced ovarian cancer in mice; (b) image the tumor growth on the peritoneum; and (c) calculate the specific energy and mean absorbed dose to tumors and critical organs. METHODS: Two experiments with 5-wk-old nude mice (n = 100 + 93), intraperitoneally inoculated with approximately 1 x 10(7) NIH:OVCAR-3 cells, were done. At either 1, 3, 4, 5, or 7 wk after inoculation animals were intraperitoneally treated with approximately 400 kBq 211At-MX35 F(ab')2 (n = 50 + 45), approximately 400 kBq 211At-Rituximab F(ab')2 (n = 25 + 24), or unlabeled Rituximab F(ab')2 (n = 25 + 24). At the time of treatment 29 animals were sacrificed and biopsies were taken for determination of tumor sizes using scanning electron microscopy (SEM). Eight weeks after each treatment the animals were sacrificed and the presence of macro- and microscopic tumors and ascites was determined. The specific energy and mean absorbed dose to tumors were calculated. The activity concentration was measured in critical organs and abdominal fluid. RESULTS: When given treatment 1, 3, 4, 5, or 7 wk after cell inoculation the tumor-free fraction (TFF) was 95%, 68%, 58%, 47%, 26%, and 100%, 80%, 20%, 20%, and 0% when treated with 211At-MX35 F(ab')2 or 211At-Rituximab F(ab')2, respectively. The SEM images revealed maximum tumor radius of approximately 30 mum 1 wk after cell inoculation, increasing to approximately 340 mum at 7 wk. Specific energy to cell nuclei varied between 0 and approximately 540 Gy, depending on assumptions regarding activity distribution and tumor size. The mean absorbed dose to thyroid, kidneys, and bone marrow was approximately 35, approximately 4, and approximately 0.3 Gy, respectively. CONCLUSION: Treatment with 211At-MX35 F(ab')2 or 211At-Rituximab F(ab')2 resulted in a TFF of 95%-100% when the tumor radius was < or =30 microm. The TFF was decreased (TFF < or = 20%) for 211At-Rituximab F(ab')2 when the tumor radius exceeded the range of the alpha-particles. The specific antibody gave for these tumor sizes a significantly better TFF, explained by a high mean absorbed dose (>22 Gy) from the activity bound to the tumor surface and probably some contribution from penetrating activity.
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| 43. |
- Elgqvist, Jörgen, 1963, et al.
(författare)
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Fractionated radioimmunotherapy of intraperitoneally growing ovarian cancer in nude mice with 211At-MX35 F(ab')2: therapeutic efficacy and myelotoxicity
- 2006
-
Ingår i: Nucl Med Biol. - : Elsevier BV. - 0969-8051. ; 33:8, s. 1065-72
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The aim of this study was to investigate the therapeutic efficacy and myelotoxicity during fractionated radioimmunotherapy of ovarian cancer in mice. The study was performed using the monoclonal antibody MX35 F(ab')(2) labeled with the alpha-particle emitter (211)At. METHODS: Animals were intraperitoneally inoculated with approximately 1x10(7) cells of the cell line NIH:OVCAR-3. Four weeks later, the mice were given the first treatment. Six groups of animals were intraperitoneally injected with approximately 800, 3x approximately 267, approximately 400, 3x approximately 133, approximately 50 or 3x approximately 17 kBq (211)At-MX35 F(ab')(2) (n=18 in each group). The second and third injections for Groups 2, 4 and 6 were given 4 and 8 days after the first injection, respectively. As controls, animals were treated with unlabeled MX35 F(ab')(2) (n=12). Eight weeks after the last injection, the animals were sacrificed and the presence of macro- and microscopic tumors and ascites was determined. Blood counts were determined for each mouse in Groups 1 and 2 before the first injection and 3, 7, 11, 15 and 23 days after the first injection. The calculation of the mean absorbed dose to the bone marrow was based on the ratio between the (211)At-activity concentration in bone and blood [i.e., the bone-to-blood ratio (BBLR)] as well as that between the (211)At-activity concentration in bone marrow and blood [i.e., the bone-marrow-to-blood ratio (BMBLR)] and the cumulated activity and absorbed fraction of the alpha-particles emitted by (211)At in the bone marrow. RESULTS: The tumor-free fractions of animals were 56% and 41% when treated with approximately 800 kBq and 3x approximately 267 kBq (211)At-MX35 F(ab')(2), respectively; 39% and 28% when treated with approximately 400 kBq and 3x approximately 133 kBq (211)At-MX35 F(ab')(2), respectively; and 17% and 22% when treated with approximately 50 kBq or 3x approximately 17 kBq (211)At-MX35 F(ab')(2), respectively. The nadir of the white blood cell (WBC) counts was decreased (from 46% to 19%, compared with the baseline WBC counts) and delayed (from Day 4 to Day 11 after the first injection) during the fractionated treatment compared with the single-dose treatment. The percentage of injected activity per gram (%IA/g) for blood, bone and bone marrow all peaked 6 h after injection at 13.80+/-1.34%IA/g, 4.00+/-0.69%IA/g and 8.28+/-1.38%IA/g, respectively. The BBLR and BMBLR were 0.20+/-0.04 and 0.58+/-0.01, respectively. The mean absorbed dose to bone marrow was approximately 0.4 Gy after intraperitoneally injecting approximately 800 kBq (211)At-MX35 F(ab')(2). CONCLUSION: No advantage was observed in the therapeutic efficacy of using a fractionated regimen compared with a single administration, with the same total amount of administered activity. Alleviation of the myelotoxicity was observed during the fractionated regimen in terms of decreased suppression and delayed nadir of the WBC counts. No thrombocytopenia was observed during either regimen.
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| 44. |
- Engblom, David, 1975-, et al.
(författare)
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Induction of microsomal prostaglandin E synthase in the rat brain endothelium and parenchyma in adjuvant-induced arthritis
- 2002
-
Ingår i: Journal of Comparative Neurology. - : Wiley. - 0021-9967 .- 1096-9861. ; 452:3, s. 205-214
-
Tidskriftsartikel (refereegranskat)abstract
- Although central nervous symptoms such as hyperalgesia, fatigue, malaise, and anorexia constitute major problems in the treatment of patients suffering from chronic inflammatory disease, little has been known about the signaling mechanisms by which the brain is activated during such conditions. Here, in an animal model of rheumatoid arthritis, we show that microsomal prostaglandin E-synthase, the inducible terminal isomerase in the prostaglandin E2-synthesizing pathway, is expressed in endothelial cells along the blood-brain barrier and in the parenchyma of the paraventricular hypothalamic nucleus. The endothelial cells but not the paraventricular hypothalamic cells displayed a concomitant induction of cyclooxygenase-2 and expressed interleukin-1 type 1 receptors, which indicates that the induction is due to peripherally released cytokines. In contrast to cyclooxygenase-2, microsomal prostaglandin E synthase had very sparse constitutive expression, suggesting that it could be a target for developing drugs that will carry fewer side effects than the presently available cyclooxygenase inhibitors. These findings, thus, suggest that immune-to-brain communication during chronic inflammatory conditions involves prostaglandin E2-synthesis both along the blood-brain barrier and in the parenchyma of the hypothalamic paraventricular nucleus and point to novel avenues for the treatment of the brain-elicited disease symptoms during these conditions.
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| 45. |
- Eriksson, Johanna, et al.
(författare)
-
Närståendes upplevelser på ett vård- och omsorgsboende : en kvalitativ intervjustudie
- 2018
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Det blir allt fler äldre personer i samhället idag eftersom vi lever längre. Ett större antaläldre personer kan innebära att fler närstående blir involverade i den äldre personenslivssituation och vård. Den personcentrerade omvårdnadsmodellen visar att närståendeär en viktig resurs för den äldre och för den äldres välbefinnande. Idag ska närståendekunna vara ett naturligt inslag i vården av den äldre personen. Sedan år 2009när nya bestämmelsen i Socialtjänstlagen kom, har vården ett ansvar att ge närståendestöd och vägledning. Detta leder till att en dialog mellan vårdpersonal och närståendeär betydande för att främja den äldres hälsa, men också för att främja närståendes delaktighetoch välbefinnande. Syftet med studien var att undersöka närståendes upplevelserav att ha en äldre person vid ett vård- och omsorgsboende. Studien har en kvalitativstudiedesign. Tre fokusgruppsintervjuer och två enskilda intervjuer genomfördesmed sammanlagt 26 närstående till en äldre person på ett vård- och omsorgsboende.Intervjuerna analyserades med en konventionell innehållsanalys. Ett gott bemötandeoch en öppen kommunikation med vårdpersonalen gjorde att de närstående kände sigvälkomna och sedda som en viktig del i vården. Närstående upplevde trygghet då desjälva och den äldre personen kände sig hemmastadda på vård- och omsorgsboendet.Slutsats: Personalen har en betydelsefull roll för närståendes välbefinnande och delaktigheti vården på ett vård- och omsorgsboende.
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| 46. |
- Eriksson, Johanna, et al.
(författare)
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Närståendes upplevelser på ett vård- och omsorgsboende : en kvalitativ intervjustudie
- 2018
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Det blir allt fler äldre personer i samhället idag eftersom vi lever längre. Ett större antaläldre personer kan innebära att fler närstående blir involverade i den äldre personenslivssituation och vård. Den personcentrerade omvårdnadsmodellen visar att närståendeär en viktig resurs för den äldre och för den äldres välbefinnande. Idag ska närståendekunna vara ett naturligt inslag i vården av den äldre personen. Sedan år 2009när nya bestämmelsen i Socialtjänstlagen kom, har vården ett ansvar att ge närståendestöd och vägledning. Detta leder till att en dialog mellan vårdpersonal och närståendeär betydande för att främja den äldres hälsa, men också för att främja närståendes delaktighetoch välbefinnande. Syftet med studien var att undersöka närståendes upplevelserav att ha en äldre person vid ett vård- och omsorgsboende. Studien har en kvalitativstudiedesign. Tre fokusgruppsintervjuer och två enskilda intervjuer genomfördesmed sammanlagt 26 närstående till en äldre person på ett vård- och omsorgsboende.Intervjuerna analyserades med en konventionell innehållsanalys. Ett gott bemötandeoch en öppen kommunikation med vårdpersonalen gjorde att de närstående kände sigvälkomna och sedda som en viktig del i vården. Närstående upplevde trygghet då desjälva och den äldre personen kände sig hemmastadda på vård- och omsorgsboendet.Slutsats: Personalen har en betydelsefull roll för närståendes välbefinnande och delaktigheti vården på ett vård- och omsorgsboende.
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| 49. |
- Grönbeck-Linden, Ingela, 1955, et al.
(författare)
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Development of an instrument to assess oral hygiene ability in older adults: The oral hygiene ability instrument
- 2020
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Ingår i: Gerodontology. - : Wiley. - 0734-0664 .- 1741-2358. ; 37:1, s. 19-27
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To describe the development process of an instrument to assess the ability to manage daily oral hygiene and the cause of impaired oral hygiene. The instrument is initially aimed for use by the dental team in the ageing population. Background: Oral hygiene is an important component of oral health. Inability to manage oral hygiene combined with other risk factors often results in poor oral health and impaired quality of life. Methods: A guideline for instrument development was used during the construction of the instrument. The method included three phases: I. planning: the purpose and target group of the instrument were determined, and a literature review and qualitative focus-group study were conducted; II. construction: objectives were formulated, and a pool of items was built; and III. evaluation and validation, which included two pilot studies, interviews, item analyses and revision of the instrument. Results: The planning and construction phases resulted in an instrument with 47 items comprising three parts: (a) interview, (b) clinical examination and (c) observation of activities of daily living (oral hygiene). After two pilot studies, the instrument was found to have good content validity. Analyses of qualitative and quantitative data resulted in a reduction in the number of items to 33. Conclusion: OHAI can be a valuable tool as a preventive method to identify older adults at risk of impaired oral health. However, the instrument needs further evaluation before wider use. © 2019 Gerodontology Association and John Wiley & Sons Ltd
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| 50. |
- Grönbeck-Linden, Ingela, 1955, et al.
(författare)
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Development of the Oral Hygiene Ability Index (OHAI).
- 2018
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Ingår i: 96th General Session of the International Association for Dental Research, IADR. 25-28 July 2018, London, England.
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Konferensbidrag (refereegranskat)
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