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1.	Nielsen, Niklas, et al. (author) Target temperature management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design 2012 In: American Heart Journal. - : Elsevier. - 0002-8703 .- 1097-6744. ; 163:4, s. 541-548 Journal article (peer-reviewed)abstract Background Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32 degrees C to 34 degrees C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known. less thanbrgreater than less thanbrgreater thanMethods The TTM trial is an investigator-initiated, international, randomized, parallel-group, and assessor-blinded clinical trial designed to enroll at least 850 adult, unconscious patients resuscitated after out-of-hospital cardiac arrest of a presumed cardiac cause. The patients will be randomized to a target temperature management of either 33 degrees C or 36 degrees C after return of spontaneous circulation. In both groups, the intervention will last 36 hours. The primary outcome is all-cause mortality at maximal follow-up. The main secondary outcomes are the composite outcome of all-cause mortality and poor neurologic function (cerebral performance categories 3 and 4) at hospital discharge and at 180 days, cognitive status and quality of life at 180 days, assessment of safety and harm. less thanbrgreater than less thanbrgreater thanDiscussion The TTM trial will investigate potential benefit and harm of 2 target temperature strategies, both avoiding hyperthermia in a large proportion of the out-of-hospital cardiac arrest population.
2.	Sjökvist, Jesper, et al. (author) Physical and performance characteristics of high-level female soccer goalkeepers 2012 Conference paper (peer-reviewed)
3.	Abarkan, Abdellah, et al. (author) Corona hotar förvärra svenska bostadskrisen. 108 forskare: Sveriges regering och kommuner måste förhindra en katastrof. 2020 In: Aftonbladet. - 1103-9000. Journal article (pop. science, debate, etc.)abstract Debattartikel och Öppet brev publicerad i tidningen Aftonbladet. 29.3. 2020.
4.	Abarkan, Abdellah, et al. (author) Lyssna på forskningen : Den visar på avregleringens problem 2019 In: Dagens nyheter. - Stockholm : Dagens nyheter. - 1101-2447. ; :10/21/2019 Journal article (pop. science, debate, etc.)
5.	Adolfsson, Jesper, et al. (author) Faktaunderlag med klimat utmaningar för Västra Götaland Ett gott liv i en fossiloberoende region 2015 Reports (other academic/artistic)
6.	Andersson, Erik, et al. (author) Cost-effectiveness of an internet-based booster program for patients with obsessive-compulsive disorder : Results from a randomized controlled trial 2015 In: Journal of Obsessive-Compulsive and Related Disorders. - : Elsevier. - 2211-3649 .- 2211-3657. ; 4, s. 14-19 Journal article (peer-reviewed)abstract Cognitive behavior therapy (CBT) is an effective treatment for OCD when delivered face-to-face, in group-format and also via the internet. However, despite overall large effect sizes, a considerable amount of the patients relapse. One intervention that has the potential to reduce these relapse rates is booster programs, but if booster program is a cost-effective method of preventing relapse is still unknown. We used health economical data from a recent randomized controlled trial, where patients who had undergone an internet-based CBT were randomly allocated to receive an additional booster program. Assessment points were 4-, 7-, 12- and 24-month. Health economical data were primarily analyzed using a societal perspective. Results showed that the booster program was effective in preventing relapse, and the cost of one avoided relapse was estimated to $1066-1489. Cost-effectiveness acceptability curves showed that the booster program had a 90% probability of being cost-effective given a willingness to pay of $1000-1050 the first year, but this figure grew considerably after two years ($2500-5500). We conclude that internet-based booster programs are probably a cost-effective alternative within one-year time frame and that more treatment may be needed to maintain adequate cost-effectiveness up to two years. (C) 2014 Elsevier Inc. All rights reserved.
7.	Andersson, Erik, et al. (author) d-Cycloserine vs Placebo as Adjunct to Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder and Interaction With Antidepressants A Randomized Clinical Trial 2015 In: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 72:7, s. 659-667 Journal article (peer-reviewed)abstract IMPORTANCE It is unclear whether D-cycloserine (DCS), a partial N-methyl-D-aspartate agonist that enhances fear extinction, can augment the effects of exposure-based cognitive behavioral therapy (CBT) for obsessive-compulsive disorder (OCD). OBJECTIVES To examine whether DCS augments the effects of CBT for OCD and to explore (post hoc) whether concomitant antidepressant medication moderates the effects of DCS. DESIGN, SETTING, AND PARTICIPANTS A 12-week, double-blind randomized clinical trial with 3-month follow-up conducted at an academic medical center between September 4, 2012, and September 26, 2013. Participants included 128 adult outpatients with a primary diagnosis of OCD and a Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score of 16 or higher. Concurrent antidepressant medication was permitted if the dose had been stable for at least 2 months prior to enrollment and remained unchanged during the trial. The main analysis was by intention-to-treat population. INTERVENTIONS All participants received a previously validated Internet-based CBT protocol over 12 weeks and were randomized to receive either 50 mg of DCS or placebo, administered 1 hour before each of 5 exposure and response prevention tasks. MAIN OUTCOMES AND MEASURES Clinician-administered Y-BOCS score at week 12 and at 3-month follow-up. Remission was defined as a score of 12 or lower on the Y-BOCS. RESULTS In the primary intention-to-treat analyses, DCS did not augment the effects of CBT compared with placebo (mean [SD] clinician-rated Y-BOCS score, DCS: 13.86 [6.50] at week 12 and 12.35 [7.75] at 3-month follow-up; placebo: 11.77 [5.95] at week 12 and 12.37 [6.68] at 3-month follow-up) but showed a significant interaction with antidepressants (clinician-rated Y-BOCS, B = -1.08; Z = -2.79; P = .005). Post hoc analyses revealed that antidepressants significantly impaired treatment response in the DCS group but not the placebo group, at both posttreatment and follow-up (clinician-rated Y-BOCS: t(62) = -3.00; P = .004; and t(61) = -3.49; P < .001, respectively). In the DCS group, a significantly greater proportion of antidepressant-free patients achieved remission status at follow-up (60% [95% CI, 45%-74%]) than antidepressant-medicated patients (24% [95% CI, 9%-48%]) (P = .008). Antidepressants had no effect in the placebo group (50% [95% CI, 36%-64%] remission rate in both groups). CONCLUSIONS AND RELEVANCE The findings suggest that antidepressants may interact with DCS to block its facilitating effect on fear extinction. Use of DCS may be a promising CBT augmentation strategy but only in antidepressant-free patients with OCD.
8.	Andersson, Erik, et al. (author) Long-term efficacy of Internet-based cognitive behavior therapy for obsessive-compulsive disorder with or without booster : a randomized controlled trial 2014 In: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 44:13, s. 2877-2887 Journal article (peer-reviewed)abstract Background. As relapse after completed cognitive behavior therapy (CBT) for obsessive-compulsive disorder (OCD) is common, many treatment protocols include booster programs to improve the long-term effects. However, the effects of booster programs are not well studied. In this study, we investigated the long-term efficacy of Internet-based CBT (ICBT) with therapist support for OCD with or without an Internet-based booster program. Method. A total of 101 participants were included in the long-term follow-up analysis of ICBT. Of these, 93 were randomized to a booster program or no booster program. Outcome assessments were collected at 4, 7, 12 and 24 months after receiving ICBT. Results. The entire sample had sustained long-term effects from pre-treatment to all follow-up assessments, with large within-group effect sizes (Cohen's d=1.58-2.09). The booster group had a significant mean reduction in OCD symptoms compared to the control condition from booster baseline (4 months) to 7 months, but not at 12 or 24 months. Participants in the booster group improved significantly in terms of general functioning at 7, 12 and 24 months, and had fewer relapses. Kaplan-Meier analysis also indicated a significantly slower relapse rate in the booster group. Conclusions. The results suggest that ICBT has sustained long-term effects and that adding an Internet-based booster program can further improve long-term outcome and prevent relapse for some OCD patients.
9.	Andersson, Erik, et al. (author) Predictors and moderators of Internet-based cognitive behavior therapy for obsessive-compulsive disorder : Results from a randomized trial 2015 In: Journal of Obsessive-Compulsive and Related Disorders. - : Elsevier. - 2211-3649 .- 2211-3657. ; 4, s. 1-7 Journal article (peer-reviewed)abstract Internet-based cognitive behavior therapy (ICBT) for obsessive-compulsive disorder (OCD) has shown efficacy in randomized trials but many patients do not respond to the treatment, we therefore need to find predictors and moderators of treatment response. In this study, we analyzed predictors of ICBT response using both post-treatment as well as 24-month outcome data. As half of the participants were randomized to receive an Internet-based booster program as an adjunct to ICBT, we also investigated moderators of ICBT with or without booster. Results showed that more severe baseline OCD symptoms predicted worse end state outcome but also higher degree of change. Furthermore, high degree of working alliance predicted better outcome but patients with primary disgust emotions had worse treatment effects. The moderator analysis also indicated that scoring high on the obsessing subscale on the Obsessive-Compulsive Inventory-Revised predicted worse treatment outcome in the booster group. In conclusion, there are some possible predictors and moderators of ICBT for OCD but more research is needed with larger and clinically representative samples. (C) 2014 Elsevier Inc. All rights reserved.
10.	Andersson, Erik, et al. (author) Testing the Mediating Effects of Obsessive Beliefs in Internet-Based Cognitive Behaviour Therapy for Obsessive-Compulsive Disorder : Results from a Randomized Controlled Trial 2015 In: Clinical Psychology and Psychotherapy. - : Wiley-Blackwell. - 1063-3995 .- 1099-0879. ; 22:6, s. 722-732 Journal article (peer-reviewed)abstract Although cognitive interventions for obsessive-compulsive disorder (OCD) have been tested in randomized trials, there are few trials that have tested the specific mechanisms of cognitive interventions, i.e. how they achieve their effects. In this study, we aimed to investigate the mediating effects of a short cognitive intervention in the treatment of OCD and used data from a recently conducted randomized controlled trial where 101 participants were allocated to either Internet-based CBT (ICBT) or to a control condition. Obsessive beliefs were measured at pre-treatment, at the time they had received the cognitive intervention, and also at post-treatment. Weekly OCD symptoms were measured throughout the 10 weeks of treatment. We hypothesized that (1) the ICBT group would have greater reductions in obsessive beliefs (controlling for change in OCD symptoms) after completing the cognitive intervention, and that (2) this reduction would, in turn, predict greater OCD symptom reduction throughout the rest of the treatment period. Contrary to our expectations, the longitudinal mediation analysis indicated that (1) being randomized to ICBT actually increased the degree of obsessive beliefs after receiving the cognitive intervention at weeks 1-3, and (2) increase in obsessive beliefs predicted better outcome later in treatment. However, when repeating the analysis using cross-sectional data at post-treatment, the results were in line with the initial hypotheses. Results were replicated when the control condition received ICBT. We conclude that, although obsessive beliefs were significantly reduced at post-treatment for the ICBT group, early increase rather than decrease in obsessive beliefs predicted favourable outcome. Copyright (C) 2014 John Wiley & Sons, Ltd.
11.	Andersson, Jonas, et al. (author) Interoperabilitet 2009 Reports (other academic/artistic)abstract Effektiv medverkan i expeditionära insatser ställer höga krav på förmågan att samverka med andra nationers förband på alla krigföringsnivåer och inom ett stort antal sakområden. Interoperabilitet betecknar förmågan att utbyta tjänster i syfte att nå gemensam effekt. "Expeditionär förmåga" ställer nya krav på Försvarsmakten avseende interoperabilitet med andra nationer och organisationer.Denna rapport sammanfattar en studie i form av en kunskapsinventering som gjorts inom ramen för FoT temaområde Expeditionär förmåga. Avsikten med rapporten är att sammanställa befintlig kunskap inom området, att skapa en nuläges- och problemområdesbeskrivning samt att ta fram förslag till inriktning för det fortsatta studiearbetet. Studien sammanställer erfarenheter och kunskaper avseende begreppet interoperabilitet utifrån ett flertal infallsvinklar, bland annat kulturella, tekniska och organisatoriska. Inriktningen har legat på källor som har bedömts kunna vara av intresse för att bidra till att höja effekten av svenska expeditionära insatser. Kunskapsinsamlingen har baserats på öppna källor i form av böcker, rapporter, studier, uppsatser och artiklar samt intervjuer med svenska officerare.Rapporten beskriver kortfattat begreppet interoperabilitet med utgångspunkt i befintliga definitioner, sakområden och organisatoriska nivåer. Vidare ges en nulägesbeskrivning som dels redogör för konkreta problem i den operativa verkligheten under insats och övning och dels för ett antal organisationers och nationers forskning och utveckling inom området. I rapporten läggs även vikt på att sammanfatta metoder och ramverk för att validera och mäta interoperabiliteten hos ett förband eller ett tekniskt system. Rapporten avslutas med en diskussion om praktiska vägar till "rätt" interoperabilitet samt slutsatser och rekommendationer för fortsatt studiearbete.
12.	Andersson, Jan, et al. (author) Trafiksäkerhetspåverkan vid omkörning av 30-metersfordon 2011 Reports (other academic/artistic)abstract Trafikverket överväger att tillåta längre och tyngre fordon på vägarna förutsatt att de inte påverkar trafiksäkerheten negativt. Syftet med studien var att undersöka säkerhetseffekten av fordonslängd, speciellt med avseende på olycksrisken vid omkörningar. Intervjuade förare av en 30-meters timmerbil hade inte upplevt de farhågor som förare av normallånga lastbilar uttryckt i samband med trånga rondeller och korsningar, men de nämner betydelsen av stödjande åkeri, arbetsmiljö och fordonsutrustning. En simulatorstudie studerade bilförares omkörningar av ett 30- och ett 18,75-metersfordon på en 2+1-väg i situationen då två körfält går ihop till ett. Tidluckan till ett återstående körfält var i genomsnitt 0,2 s (sign.) kortare efter omkörningar av 30-metersfordonet i situationer då bakänden var i samma relativa position som för 18,75-metersfordonet vid början av omkörningen. En fältstudie analyserade videoinspelade omkörningar av en 30- och en 24-meters timmerbil på en 2+1-väg och en tvåfältig väg. Ingen signifikant skillnad i tidluckor kunde påvisas mellan omkörningar av de två fordonen för någon av vägtyperna. Det senare resultatet ska dock tolkas med försiktighet på grund av ojämnt distribuerad data som insamlats under specifika förhållanden. Slutsatserna är att det finns en liten tendens till negativ säkerhetseffekt vid omkörningar av längre fordon, och att fler fältstudier är nödvändiga.
13.	Andersson, Ola, et al. (author) Effects of delayed compared with early umbilical cord clamping on maternal postpartum hemorrhage and cord blood gas sampling : a randomized trial 2013 In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 92:5, s. 567-574 Journal article (peer-reviewed)abstract Objective. To investigate the effect of delayed cord clamping (DCC) compared with early cord clamping (ECC) on maternal postpartum hemorrhage (PPH) and umbilical cord blood gas sampling. Design. Secondary analysis of a parallel-group, single-center, randomized controlled trial. Setting. Swedish county hospital. Population. 382 term deliveries after a low-risk pregnancy. Methods. Deliveries were randomized to DCC (>= 180 seconds, n = 193) or ECC (<= 10 seconds, n = 189). Maternal blood loss was estimated by the midwife. Samples for blood gas analysis were taken from one umbilical artery and the umbilical vein, from the pulsating unclamped cord in the DCC group and from the double-clamped cord in the ECC group. Samples were classified as valid when the arterial-venous difference was -0.02 or less for pH and 0.5 kPa or more for pCO(2). Main outcome measures. PPH and proportion of valid blood gas samples. Results. The differences between the DCC and ECC groups with regard to PPH(1.2%, p = 0.8) and severe PPH(-2.7%, p = 0.3) were small and non-significant. The proportion of valid blood gas samples was similar between theDCC (67%, n = 130) and ECC (74%, n = 139) groups, with 6% (95% confidence interval: -4%-16%, p = 0.2) fewer valid samples after DCC. Conclusions. Delayed cord clamping, compared with early, did not have a significant effect on maternal postpartum hemorrhage or on the proportion of valid blood gas samples. We conclude that delayed cord clamping is a feasible method from an obstetric perspective.
14.	Andersson, Sofia Lovisa, et al. (author) Long term trials with membrane bioreactor for enhanced wastewater treatment coupled with compact sludge treatment -pilot Henriksdal 2040, results from 2020 2021 Reports (other academic/artistic)abstract Stockholm’s wastewater treatment plant (WWTP) in is currently retrofitting from a conventional activated sludge process to a new membrane bioreactor (MBR) process. It also includes new treatment steps for sludge handling. Stockholm Vatten och Avfall (SVOA) and IVL have since 2014 conducted long-term MBR studies in pilot scale at the R&D facility Hammarby Sjöstadsverk. This report present results from the pilot operation during 2020. The MBR-pilot was continuously operated at a higher inflow than the design average flow. The average effluent concentration of nitrogen and phosphorus met the effluent requirements of the future WWTP also this year. A low consumption of phosphorus precipitation chemicals could be achieved mainly due to a high Bio-P activity. The pilot showed that glycerol can be a good temporary carbon source at Henriksdal WWTP during startup. Like previous years, the membranes in membrane tank 1 (MT1) was cleaned with oxalic acid and the membranes in MT2 with citric acid. Several tests to optimize the chemical consumption for membrane cleaning were performed. Recovery cleanings (RC) of the membranes were performed twice in 2020.In the sludge pilot, a thermophilic and a mesophilic hydraulic retention time (HRT) crash test showed stable performance down to 4 days HRT. The overall resource consumption in the pilot showed that the optimization of phosphorus precipitation and membrane cleaning chemicals resulted in a significantly lower dosing than design values for the future Henriksdal WWTP.
15.	Andersson, Sofia Lovisa, et al. (author) Långtidsförsök med membranbioreaktor för förbättrad avloppsvattenrening i kombination med kompakt slambehandling 2023 Reports (other academic/artistic)abstract Henriksdals reningsverk i Stockholm byggs nu ut och om för ökad kapacitet (från 0,8 till 1,6 miljoner PE) och för förbättrad reningsgrad (6 mg TN/l, 0,20 mg TP/L, 5 mg BOD7/l). Projektet inkluderar uppgradering av den befintliga konventionella aktivslamprocessen till en ny membranbioreaktorprocess (MBR) med mer än 1,6 m2 installerad membranyta.Det inkluderar även utökad förbehandling och ett nytt steg för primärslamförtjockning. Termofil rötning av tjockt slam (~6 % TS) vid hög organisk belastning och relativt låg uppehållstid kommer ersätta dagens mesofila rötning.För att öka kunskapen om MBR-teknik i nordiskt klimat har Stockholm Vatten och Avfall (SVOA) och IVL Svenska Miljöinstitutet genomfört långtidsstudier på en membranprocess i pilotskala på FoU-anläggningen Hammarby Sjöstadsverk, som ligger i anslutning till Henriksdals reningsverk. MBR-piloten togs i drift 2013 och byggdes om till sin nuvarande utformning under 2016. År 2017 kompletterades MBR-piloten med en slamlinje för att kunna studera olika aspekter av slamrötning.Under 2021 kördes MBR-piloten med ett fast inflöde på 4,1 m3/h, vilket är 37 % högre än det designade medelflödet, med externt tillförskaffad glycerol och internt producerad VFA-kolkälla för efterdenitrifikation.Aluminium (PAX) användes i stället för trevärt järn (PIX) som komplement till tvåvärt järn (FeSO4) för fosforutfällning. Detta gjordes för att testa driftstrategin för den första MBR-linjen i Henriksdals reningsverk. Medelhalter av kväve och fosfor i utgående vatten var 3,9 mg TN/L respektive 0,07 mg TP/L, vilket innebär att utsläppsvärden uppfylldes även i år. För att uppnå detta krävdes 8,6 g Fe2+/m3 och 0,9 g Al3+/m3.Under försök med fluxförhöjare tillsattes totalt 17,8 g järn (Fe2++ Fe3+)/m3. Glyceroldosen motsvarade 17,3 g COD/m3, och för användning av internt producerad VFA motsvarande dosen 15,5 g COD/m3. Den något högre förbrukningen av fosforfällningskemikalier jämfört med 2020, 1,29 mol metall per mol avlägsnad fosfor, berodde främst på en lägre bio-P aktivitet under 2021. År 2021 var fosforsläppshastigheten mycket låg under våren, ex. < 1 g PO4-P/kg VSS,h i juni men återhämtade sig under sommaren med t.ex. 5,5 g PO4-P/kg VSS,h i juli, efter att doseringen av skumdämpare stoppades.Järn- och aluminiumhalten i det aktiva slammet var 6,2 respektive 0,7 %. Genomsnittlig total slamålder under 2021 var 17,2 dagar och luftad medelslamålder var 7 dagar. Nitrifikation var alltid komplett med utgående ammoniumkoncentrationer under 2 mg/L, förutom vecka 25.Tester med användning av internt producerad VFA som kolkälla visade att den specifika COD-förbrukningen var nästan densamma som för glycerol när man jämförde årsgenomsnittet från 2021 och 2020. Utgående nitrat och total kvävereduktion var liknande under försöket med VFA som resten av året, då glycerol användes.Liksom tidigare år rengjordes membranen i membrantank 1 (MT1) med oxalsyra och membranen i MT2 med citronsyra. Båda membranen rengjordes också med natriumhypoklorit. Membranen kördes med ett genomsnittligt flux på 21 till 25 L/(m2·h), men med startvecka 25 testades fullskaledesignens maximala nettoflux på 30 L/(m2·h) i piloten under 25 veckor. Netto-TMP varierade mellan 49 och 218 mbar för MT1 och mellan 51 och 146 mbar för MT2. TMP reducerades efter varje återhämtningsrengöring (RC) med hypoklorit, men effekten varade inte länge. Permeabiliteten var generellt över 200 L/(m2·h·bar) under hela 2021–2022 för båda membranen. Återhämtningsrengöringar gjordes två gånger med hypoklorit och en gång med syror under 2021. Under 2022 genomfördes en slutlig RC, först med hypoklorit sedan med syror. Den första RC för MT1 resulterade i en tydlig ökning av permeabiliteten efter rengöring. För MT2 var den största ökningen av permeabiliteten resultatet av en citronsyra-MC (en vecka efter hypoklorit-RC).Följande RC i slutet av 2021 och i mars 2022 hade tydliga men mindre positiva inverkan på permeabiliteten. Före den första RC var permeabiliteten högre för MT1 (rengöras med oxalsyra) jämfört med MT2 (rengöras med citronsyra). Efter de första RC hade båda membranen liknande permeabilitet. Som ett resultat av den tuffa driftstrategin från vecka 25 2021 minskade permeabiliteten ganska snabbt efter RC. MT2 nådde en stabil nivå runt 250-300 L/(m2·h·bar) medan MT1 sjönk ytterligare till som lägst 200 L/(m2·h·bar).Utsläpp av klorerade föreningar mättes under den slutliga återställningsrengöringen med natriumhypoklorit. Utsläppsprocessen var långsammare än förväntat och generellt sett observerades inga tydliga tecken på dämpning av utsläppen under provtagningens 21 timmar. Även om sammansatta prover på flera timmar under natten inte ger tillräckligt med detaljer, drogs slutsatsen att utsläppen kan vara skadliga under hela RC-processen ur ett exponeringsperspektiv. Exempelvis nådde trikloramin sin topp vid 36 gånger den rekommenderade gränsen, klorgas vid 73 % av korttidsexponeringsgränsen (15 min exponering) och kloroform vid 9 % av den yrkesmässiga exponeringsgränsen (genomsnittlig arbetsdag på 8 timmar).För att följa upp tidigare mätningar av växthusgaserna lustgas (N2O) och metan (CH4) genomfördes en ny mätkampanj under flera månader i 2021. Generellt sett var utsläppen som observerades 2021 betydligt högre än i tidigare kampanjer och särskilt höga N2O-utsläpp från membrantanken kunde observeras. Någon tydlig orsak kunde inte identifieras men den högre inkommande belastningen med bibehållna reningskrav och ett "bättre" provtagningsupplägg kan delvis vara en förklaring.I samarbete med Kemira genomfördes tester med en fluxförhöjande produkt (flux enhancer). Ingen uppenbar positiv eller negativ förändring i permeabiliteten på grund av dosering av fluxförhöjare kunde dock identifieras utifrån de kontinuerliga processparametrar som övervakades och vanliga variationer i permeabilitet samt effekten av membranrengöring.Eftersom skumbildning är ett vanligt fenomen i MBR-anläggningar genomfördes tester med ett skumdämpande medel som doserades i pulser och kontinuerligt till den biologiska behandlingen under perioden med kraftig skumbildning (mars-juni). Även om skumning inte upphörde helt så kunde en god minskning och kontroll av skumning uppnås. En optimal effekt konstaterades vid en kontinuerlig dos på > 10 ppm. Men även om produkten har visat sig ha en positiv effekt på skumning i MBR-piloten, framstår inte en permanent användning i fullskala som ekonomiskt genomförbar på grund av den höga förbrukningen.Tester med reducerat RAS-flöde från 4×Qin enligt design till 2×Qin syftade till att minska energiförbrukningen. Ett minskat RAS-flöde skulle dock innebära en ökad slamkoncentration i membrantankarna, vilket kan ha negativa effekter på membranets prestanda med mer igensättning, vilket i sin tur kan leda till ökad luftning för membranrengöring och behov av tätare membrantvättar. Projektgruppen kunde dock inte observera några negativa effekter av det minskade RAS-flödet på membranets prestanda.Under 2021 genomfördes tester med övergång från mesofil till termofil rötning, avvattning av rötslam efter mesofil och termofil rötning, samt termofil rötning vid hög organisk belastning (OLR) och låg hydraulisk uppehållstid (HRT) i slampiloten. Resultat visar att övergången från mesofil till termofil rötning kan ske utan större problem om den organiska belastningen minskades lite vid den mest kritiska temperaturen och att stabil drift uppnåddes efter 10-12 dagar. Att utvärdera avvattningen av mesofilt och termofilt rötat slam var svårare och inga tydliga skillnader kunde observeras. En slutsats var dock att de metoder som användes för att bestämma avvattningsbarhet eller optimal polymerdos inte framstår som tillförlitliga. Försök med hög organisk belastning vid termofil rötning visade att rötkammarens prestanda kunde bibehållas upp till en OLR på cirka 4 kg VS/m3, d och en HRT på 12 d. När belastningen ökades ytterligare och HRT minskade, minskade prestandan vad gäller utrötningsgrad och biogas-/metanproduktion, även om själva reaktordriften fortfarande var stabil.Den totala resursåtgången i piloten visade att konsumtionen av glycerol var densamma som för den framtida Henriksdalsdesignen, även om kvävebelastningen i piloten var 21 % högre och den genomsnittliga totala kvävekoncentrationen i utgående vatten var med 3,9 mg TN/L lägre än design på 6 mg TN/L. Järn-/metallförbrukningen var också 73 % av den framtida Henriksdalsdesignen, även om fosforbelastningen till piloten var cirka 50 % högre jämfört med designvärden och utgående fosfatkoncentrationerna låg under målkoncentrationen. Detta förklaras främst av EBPR-aktiviteten i pilotprojektet. Dessutom var förbrukningen av rengöringskemikalier lägre än den framtida Henriksdalsdesignen även om inflödet till piloten var 30 % högre än designen.
16.	Chew, Michelle S., et al. (author) Identification of myocardial injury using perioperative troponin surveillance in major noncardiac surgery and net benefit over the Revised Cardiac Risk Index 2022 In: British Journal of Anaesthesia. - : Elsevier. - 0007-0912 .- 1471-6771. ; 128:1, s. 26-36 Journal article (peer-reviewed)abstract BACKGROUND: Patients with perioperative myocardial injury are at risk of death and major adverse cardiovascular and cerebrovascular events (MACCE). The primary aim of this study was to determine optimal thresholds of preoperative and perioperative changes in high-sensitivity cardiac troponin T (hs-cTnT) to predict MACCE and mortality.METHODS: Prospective, observational, cohort study in patients ≥50 yr of age undergoing elective major noncardiac surgery at seven hospitals in Sweden. The exposures were hs-cTnT measured before and days 0-3 after surgery. Two previously published thresholds for myocardial injury and two thresholds identified using receiver operating characteristic analyses were evaluated using multivariable logistic regression models and externally validated. The weighted comparison net benefit method was applied to determine the additional value of hs-cTnT thresholds when compared with the Revised Cardiac Risk Index (RCRI). The primary outcome was a composite of 30-day all-cause mortality and MACCE.RESULTS: We included 1291 patients between April 2017 and December 2020. The primary outcome occurred in 124 patients (9.6%). Perioperative increase in hs-cTnT ≥14 ng L-1 above preoperative values provided statistically optimal model performance and was associated with the highest risk for the primary outcome (adjusted odds ratio 2.9, 95% confidence interval 1.8-4.7). Validation in an independent, external cohort confirmed these findings. A net benefit over RCRI was demonstrated across a range of clinical thresholds.CONCLUSIONS: Perioperative increases in hsTnT ≥14 ng L-1 above baseline values identifies acute perioperative myocardial injury and provides a net prognostic benefit when added to RCRI for the identification of patients at high risk of death and MACCE.CLINICAL TRIAL REGISTRATION: NCT03436238.
17.	Dagöö, Jesper, et al. (author) Cognitive behavior therapy versus interpersonal psychotherapy for social anxiety disorder delivered via smartphone and computer: A randomized controlled trial 2014 In: Journal of Anxiety Disorders. - : Elsevier BV. - 1873-7897 .- 0887-6185. ; 28:4, s. 410-417 Journal article (peer-reviewed)abstract In this study, a previously evaluated guided Internet-based cognitive behavior therapy for social anxiety disorder (SAD) was adapted for mobile phone administration (mCBT). The treatment was compared with a guided self-help treatment based on interpersonal psychotherapy (mIPT). The treatment platform could be accessed through smartphones, tablet computers, and standard computers. A total of 52 participants were diagnosed with SAD and randomized to either mCBT (n = 27) or mIPT (n = 25). Measures were collected at pre-treatment, during the treatment, post-treatment and 3-month follow-up. On the primary outcome measure, the Liebowitz Social Anxiety Scale - self-rated, both groups showed statistically significant improvements. However, mCBT performed significantly better than mIPT (between group Cohen's d = 0.64 in favor of mCBT). A larger proportion of the mCBT group was classified as responders at post-treatment (55.6% versus 8.0% in the mIPT group). We conclude that CBT for SAD can be delivered using modern information technology. IPT delivered as a guided self-help treatment may be less effective in this format. (c) 2014 Elsevier Ltd. All rights reserved.
18.	Enander, Jesper, et al. (author) Therapist guided internet based cognitive behavioural therapy for body dysmorphic disorder: single blind randomised controlled trial 2016 In: BMJ-BRITISH MEDICAL JOURNAL. - : BMJ PUBLISHING GROUP. - 1756-1833. ; 352:i241 Journal article (peer-reviewed)abstract OBJECTIVES To evaluate the efficacy of therapist guided internet based cognitive behavioural therapy (CBT) programme for body dysmorphic disorder (BDD-NET) compared with online supportive therapy. DESIGN A 12 week single blind parallel group randomised controlled trial. SETTING Academic medical centre. PARTICIPANTS 94 self referred adult outpatients with a diagnosis of body dysmorphic disorder and a modified Yale-Brown obsessive compulsive scale (BDD-YBOCS) score of >= 20. Concurrent psychotropic drug treatment was permitted if the dose had been stable for at least two months before enrolment and remained unchanged during the trial. INTERVENTIONS Participants received either BDD-NET (n=47) or supportive therapy (n=47) delivered via the internet for 12 weeks. MAIN OUTCOME MEASURES The primary outcome was the BDD-YBOCS score after treatment and follow-up (three and six months from baseline) as evaluated by a masked assessor. Responder status was defined as a >= 30% reduction in symptoms on the scale. Secondary outcomes were measures of depression (MADRS-S), global functioning (GAF), clinical global improvement (CGI-I), and quality of life (EQ5D). The six month follow-up time and all outcomes other than BDD-YBOCS and MADRS-S at 3 months were not pre-specified in the registration at clinicaltrials.gov because of an administrative error but were included in the original trial protocol approved by the regional ethics committee before the start of the trial. RESULTS BDD-NET was superior to supportive therapy and was associated with significant improvements in severity of symptoms of body dysmorphic disorder (BDD-YBOCS group difference -7.1 points, 95% confidence interval -9.8 to -4.4), depression (MADRS-S group difference -4.5 points, -7.5 to -1.4), and other secondary measures. At follow-up, 56% of those receiving BDD-NET were classed as responders, compared with 13% receiving supportive therapy. The number needed to treat was 2.34 (1.71 to 4.35). Self reported satisfaction was high. CONCLUSIONS CBT can be delivered safely via the internet to patients with body dysmorphic disorder. BDD-NET has the potential to increase access to evidence based psychiatric care for this mental disorder, in line with NICE priority recommendations. It could be particularly useful in a stepped care approach, in which general practitioner or other mental health professionals can offer treatment to people with mild to moderate symptoms at low risk of suicide.
19.	Johnsson, Jesper, et al. (author) Artificial neural networks improve early outcome prediction and risk classification in out-of-hospital cardiac arrest patients admitted to intensive care 2020 In: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535. ; 24:1 Journal article (peer-reviewed)abstract BACKGROUND: Pre-hospital circumstances, cardiac arrest characteristics, comorbidities and clinical status on admission are strongly associated with outcome after out-of-hospital cardiac arrest (OHCA). Early prediction of outcome may inform prognosis, tailor therapy and help in interpreting the intervention effect in heterogenous clinical trials. This study aimed to create a model for early prediction of outcome by artificial neural networks (ANN) and use this model to investigate intervention effects on classes of illness severity in cardiac arrest patients treated with targeted temperature management (TTM). METHODS: Using the cohort of the TTM trial, we performed a post hoc analysis of 932 unconscious patients from 36 centres with OHCA of a presumed cardiac cause. The patient outcome was the functional outcome, including survival at 180 days follow-up using a dichotomised Cerebral Performance Category (CPC) scale with good functional outcome defined as CPC 1-2 and poor functional outcome defined as CPC 3-5. Outcome prediction and severity class assignment were performed using a supervised machine learning model based on ANN. RESULTS: The outcome was predicted with an area under the receiver operating characteristic curve (AUC) of 0.891 using 54 clinical variables available on admission to hospital, categorised as background, pre-hospital and admission data. Corresponding models using background, pre-hospital or admission variables separately had inferior prediction performance. When comparing the ANN model with a logistic regression-based model on the same cohort, the ANN model performed significantly better (p = 0.029). A simplified ANN model showed promising performance with an AUC above 0.852 when using three variables only: age, time to ROSC and first monitored rhythm. The ANN-stratified analyses showed similar intervention effect of TTM to 33 °C or 36 °C in predefined classes with different risk of a poor outcome. CONCLUSION: A supervised machine learning model using ANN predicted neurological recovery, including survival excellently, and outperformed a conventional model based on logistic regression. Among the data available at the time of hospitalisation, factors related to the pre-hospital setting carried most information. ANN may be used to stratify a heterogenous trial population in risk classes and help determine intervention effects across subgroups.
20.	Nicholls, Ian A., et al. (author) Can we rationally design molecularly imprinted polymers? 2001 In: Analytica Chimica Acta. - San Carlos, Mexico, April 30-May 3. ; 435:1, s. 9-18 Journal article (peer-reviewed)
21.	Nicholls, Ian A., et al. (author) Can we rationally design molecularly imprinted polymers? 2001 In: Analytica Chimica Acta. ; 435:1, s. 9-18 Journal article (peer-reviewed)abstract The nearly exponential growth in the molecular imprinting literature has to a large extent been fuelled by an increasing awareness of the potential of molecular imprinting based technologies. Despite the acceptance of the technique by cognate disciplines and the demonstration of its usefulness in a number of enabling technologies, relatively little is known about the molecular level events underlying the imprinting process and subsequent recognition events. What rules govern imprint formation? Can we use such rules to rationally design molecularly imprinted polymers?
22.	Nicholls, Ian A., et al. (author) Molecularly imprinted polymers: unique possibilities for environmental monitoring 2002 In: Proceedings of Kalmar Eco-Tech'01 : conference on leachate and waste water treatment with high-tech and natural systems : the 3rd International Conference on the Establishment of Cooperation Between Companies/Institutions in the Nordic Countries and the Countries in the Baltic Sea Region : November 26 to 28, 2001 Kalmar, Sweden. - : Högskolan i Kalmar. ; , s. 285-288, s. 285-288 Conference paper (other academic/artistic)
23.	Orlando, Ludovic, et al. (author) Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse 2013 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 499:7456, s. 74- Journal article (peer-reviewed)abstract The rich fossil record of equids has made them a model for evolutionary processes(1). Here we present a 1.12-times coverage draft genome from a horse bone recovered from permafrost dated to approximately 560-780 thousand years before present (kyr BP)(2,3). Our data represent the oldest full genome sequence determined so far by almost an order of magnitude. For comparison, we sequenced the genome of a Late Pleistocene horse (43 kyr BP), and modern genomes of five domestic horse breeds (Equus ferus caballus), a Przewalski's horse (E. f. prze-walskii) and a donkey (E. asinus). Our analyses suggest that the Equus lineage giving rise to all contemporary horses, zebras and donkeys originated 4.0-4.5 million years before present (Myr BP), twice the conventionally accepted time to the most recent common ancestor of the genus Equus(4,5). We also find that horse population size fluctuated multiple times over the past 2 Myr, particularly during periods of severe climatic changes. We estimate that the Przewalski's and domestic horse populations diverged 38-72 kyr BP, and find no evidence of recent admixture between the domestic horse breeds and the Przewalski's horse investigated. This supports the contention that Przewalski's horses represent the last surviving wild horse population(6). We find similar levels of genetic variation among Przewalski's and domestic populations, indicating that the former are genetically viable and worthy of conservation efforts. We also find evidence for continuous selection on the immune system and olfaction throughout horse evolution. Finally, we identify 29 genomic regions among horse breeds that deviate from neutrality and show low levels of genetic variation compared to the Przewalski's horse. Such regions could correspond to loci selected early during domestication.
24.	Rhedin, S. A., et al. (author) Protocol Introducing a New Algorithm for Classification of Etiology in Studies on Pediatric Pneumonia: Protocol for the Trial of Respiratory Infections in Children for Enhanced Diagnostics Study 2019 In: Journal of Medical Internet Research. - : JMIR Publications Inc.. - 1438-8871. ; 21:4 Journal article (peer-reviewed)abstract Background: There is a need to better distinguish viral infections from antibiotic-requiring bacterial infections in children presenting with clinical community-acquired pneumonia (CAP) to assist health care workers in decision making and to improve the rational use of antibiotics. Objective: The overall aim of the Trial of Respiratory infections in children for ENhanced Diagnostics (TREND) study is to improve the differential diagnosis of bacterial and viral etiologies in children aged below 5 years with clinical CAP, by evaluating myxovirus resistance protein A (MxA) as a biomarker for viral CAP and by evaluating an existing (multianalyte point-of-care antigen detection test system [mariPOC respi] ArcDia International Oy Ltd.) and a potential future point-of-care test for respiratory pathogens. Methods: Children aged 1 to 59 months with clinical CAP as well as healthy, hospital-based, asymptomatic controls will be included at a pediatric emergency hospital in Stockholm, Sweden. Blood (analyzed for MxA and C-reactive protein) and nasopharyngeal samples (analyzed with real-time polymerase chain reaction as the gold standard and antigen-based mariPOC respi test as well as saved for future analyses of a novel recombinase polymerase amplification-based point-of-care test for respiratory pathogens) will be collected. A newly developed algorithm for the classification of CAP etiology will be used as the reference standard. Results: A pilot study was performed from June to August 2017. The enrollment of study subjects started in November 2017. Results are expected by the end of 2019.Conclusions: The findings from the TREND study can be an important step to improve the management of children with clinical. © 2019 Journal of Medical Internet Research. All rights reserved.
25.	Abbas, Nadeem, et al. (author) Architectural reasoning for dynamic software product lines 2013 In: Proceedings of the 17th International Software Product Line Conference co-located workshops. - New York, NY, USA : ACM Press. - 9781450323253 ; , s. 117-124 Conference paper (peer-reviewed)abstract Software quality is critical in today's software systems. A challenge is the trade-off situation architects face in the design process. Designers often have two or more alternatives, which must be compared and put into context before a decision is made. The challenge becomes even more complex for dynamic software product lines, where domain designers have to take runtime variations into consideration as well. To address the problem we propose extensions to an architectural reasoning framework with constructs/artifacts to define and model a domain's scope and dynamic variability. The extended reasoning framework encapsulates knowledge to understand and reason about domain quality behavior and self-adaptation as a primary variability mechanism. The framework is demonstrated for a self-configuration property, self-upgradability on an educational product-line.
26.	Abbas, Nadeem, et al. (author) Architectural Reasoning Support for Product-Lines of Self-adaptive Software Systems : A Case Study 2015 In: Software Architecture: 9th European Conference, ECSA 2015, Dubrovnik/Cavtat, Croatia, September 7-11, 201. - Cham : Springer. - 9783319237275 - 9783319237268 ; , s. 20-36 Conference paper (peer-reviewed)abstract Software architecture serves as a foundation for the design and development of software systems. Designing an architecture requires extensive analysis and reasoning. The study presented herein focuses on the architectural analysis and reasoning in support of engineering self-adaptive software systems with systematic reuse. Designing self-adaptive software systems with systematic reuse introduces variability along three dimensions; adding more complexity to the architectural analysis and reasoning process. To this end, the study presents an extended Architectural Reasoning Framework with dedicated reasoning support for self-adaptive systems and reuse. To evaluate the proposed framework, we conducted an initial feasibility case study, which concludes that the proposed framework assists the domain architects to increase reusability, reduce fault density, and eliminate differences in skills and experiences among architects, which were our research goals and are decisive factors for a system's overall quality.
27.	Abbas, Nadeem, 1980-, et al. (author) ASPLe : a methodology to develop self-adaptive software systems with reuse 2017 Reports (other academic/artistic)abstract Advances in computing technologies are pushing software systems and their operating environments to become more dynamic and complex. The growing complexity of software systems coupled with uncertainties induced by runtime variations leads to challenges in software analysis and design. Self-Adaptive Software Systems (SASS) have been proposed as a solution to address design time complexity and uncertainty by adapting software systems at runtime. A vast body of knowledge on engineering self-adaptive software systems has been established. However, to the best of our knowledge, no or little work has considered systematic reuse of this knowledge. To that end, this study contributes an Autonomic Software Product Lines engineering (ASPLe) methodology. The ASPLe is based on a multi-product lines strategy which leverages systematic reuse through separation of application and adaptation logic. It provides developers with repeatable process support to design and develop self-adaptive software systems with reuse across several application domains. The methodology is composed of three core processes, and each process is organized for requirements, design, implementation, and testing activities. To exemplify and demonstrate the use of the ASPLe methodology, three application domains are used as running examples throughout the report.
28.	Abbas, Nadeem, 1980-, et al. (author) ASPLe : a methodology to develop self-adaptive software systems with systematic reuse 2020 In: Journal of Systems and Software. - : Elsevier. - 0164-1212 .- 1873-1228. ; 167, s. 1-19 Journal article (peer-reviewed)abstract More than two decades of research have demonstrated an increasing need for software systems to be self-adaptive. Self-adaptation is required to deal with runtime dynamics which are difficult to predict before deployment. A vast body of knowledge to develop Self-Adaptive Software Systems (SASS) has been established. We, however, discovered a lack of process support to develop self-adaptive systems with reuse. To that end, we propose a domain-engineering based methodology, Autonomic Software Product Lines engineering (ASPLe), which provides step-by-step guidelines for developing families of SASS with systematic reuse. The evaluation results from a case study show positive effects on quality and reuse for self-adaptive systems designed using the ASPLe compared to state-of-the-art engineering practices.
29.	Abbas, Nadeem, et al. (author) Autonomic Software Product Lines (ASPL) 2010 In: ECSA '10 Proceedings of the Fourth European Conference on Software Architecture. - New York, NY, USA : ACM Press. - 9781450301794 ; , s. 324-331 Conference paper (peer-reviewed)abstract We describe ongoing work on a variability mechanism for Autonomic Software Product Lines (ASPL). The autonomic software product lines have self-management characteristics that make product line instances more resilient to context changes and some aspects of product line evolution. Instances sense the context, selects and bind the best component variants to variation-points at run-time. The variability mechanism we describe is composed of a profile guided dispatch based on off-line and on-line training processes. Together they form a simple, yet powerful variability mechanism that continuously learns, which variants to bind given the current context and system goals.
30.	Abbas, Nadeem, 1980- (author) Designing Self-Adaptive Software Systems with Reuse 2018 Doctoral thesis (other academic/artistic)abstract Modern software systems are increasingly more connected, pervasive, and dynamic, as such, they are subject to more runtime variations than legacy systems. Runtime variations affect system properties, such as performance and availability. The variations are difficult to anticipate and thus mitigate in the system design.Self-adaptive software systems were proposed as a solution to monitor and adapt systems in response to runtime variations. Research has established a vast body of knowledge on engineering self-adaptive systems. However, there is a lack of systematic process support that leverages such engineering knowledge and provides for systematic reuse for self-adaptive systems development. This thesis proposes the Autonomic Software Product Lines (ASPL), which is a strategy for developing self-adaptive software systems with systematic reuse. The strategy exploits the separation of a managed and a managing subsystem and describes three steps that transform and integrate a domain-independent managing system platform into a domain-specific software product line for self-adaptive software systems.Applying the ASPL strategy is however not straightforward as it involves challenges related to variability and uncertainty. We analyzed variability and uncertainty to understand their causes and effects. Based on the results, we developed the Autonomic Software Product Lines engineering (ASPLe) methodology, which provides process support for the ASPL strategy. The ASPLe has three processes, 1) ASPL Domain Engineering, 2) Specialization and 3) Integration. Each process maps to one of the steps in the ASPL strategy and defines roles, work-products, activities, and workflows for requirements, design, implementation, and testing. The focus of this thesis is on requirements and design.We validate the ASPLe through demonstration and evaluation. We developed three demonstrator product lines using the ASPLe. We also conducted an extensive case study to evaluate key design activities in the ASPLe with experiments, questionnaires, and interviews. The results show a statistically significant increase in quality and reuse levels for self-adaptive software systems designed using the ASPLe compared to current engineering practices.
31.	Abbas, Nadeem, 1980-, et al. (author) Harnessing Variability in Product-lines of Self-adaptive Software Systems 2015 In: Proceedings of the 19th International Conference on Software Product Line. - New York, NY, USA : ACM Press. - 9781450336130 ; , s. 191-200 Conference paper (peer-reviewed)abstract This work studies systematic reuse in the context of self-adaptive software systems. In our work, we realized that managing variability for such platforms is different compared to traditional platforms, primarily due to the run-time variability and system uncertainties. Motivated by the fact that recent trends show that self-adaptation will be used more often in future system generation and that software reuse state-of-practice or research do not provide sufficient support, we have investigated the problems and possibly resolutions in this context. We have analyzed variability for these systems, using a systematic reuse prism, and identified a research gap in variability management. The analysis divides variability handling into four activities: (1) identify variability, (2) constrain variability, (3) implement variability, and (4) manage variability. Based on the findings we envision a reuse framework for the specific domain and present an example framework that addresses some of the identified challenges. We argue that it provides basic support for engineering self-adaptive software systems with systematic reuse. We discuss some important avenues of research for achieving the vision.
32.	Abbas, Nadeem, 1980-, et al. (author) Knowledge evolution in autonomic software product lines 2011 In: SPLC '11 Proceedings of the 15th International Software Product Line Conference, Volume 2. - New York, NY, USA : ACM Press. - 9781450307895 ; , s. 36:1-36:8 Conference paper (peer-reviewed)abstract We describe ongoing work in knowledge evolution management for autonomic software product lines. We explore how an autonomic product line may benefit from new knowledge originating from different source activities and artifacts at run time. The motivation for sharing run-time knowledge is that products may self-optimize at run time and thus improve quality faster compared to traditional software product line evolution. We propose two mechanisms that support knowledge evolution in product lines: online learning and knowledge sharing. We describe two basic scenarios for runtime knowledge evolution that involves these mechanisms. We evaluate online learning and knowledge sharing in a small product line setting that shows promising results.
33.	Abbas, Nadeem, 1980-, et al. (author) Modeling Variability in Product Lines Using Domain Quality Attribute Scenarios 2012 In: Proceedings of the WICSA/ECSA 2012 Companion Volume. - New York, NY, USA : ACM Press. - 9781450315685 ; , s. 135-142 Conference paper (peer-reviewed)abstract The concept of variability is fundamental in software product lines and a successful implementation of a product line largely depends on how well domain requirements and their variability are specified, managed, and realized. While developing an educational software product line, we identified a lack of support to specify variability in quality concerns. To address this problem we propose an approach to model variability in quality concerns, which is an extension of quality attribute scenarios. In particular, we propose domain quality attribute scenarios, which extend standard quality attribute scenarios with additional information to support specification of variability and deriving product specific scenarios. We demonstrate the approach with scenarios for robustness and upgradability requirements in the educational software product line.
34.	Abbas, Nadeem, et al. (author) Rigorous architectural reasoning for self-adaptive software systems 2016 In: Proceedings. - : IEEE. - 9781509021314 ; , s. 11-18 Conference paper (peer-reviewed)abstract Designing a software architecture requires architectural reasoning, i.e., activities that translate requirements to an architecture solution. Architectural reasoning is particularly challenging in the design of product-lines of self-adaptive systems, which involve variability both at development time and runtime. In previous work we developed an extended Architectural Reasoning Framework (eARF) to address this challenge. However, evaluation of the eARF showed that the framework lacked support for rigorous reasoning, ensuring that the design complies to the requirements. In this paper, we introduce an analytical framework that enhances eARF with such support. The framework defines a set of artifacts and a series of activities. Artifacts include templates to specify domain quality attribute scenarios, concrete models, and properties. The activities support architects with transforming requirement scenarios to architecture models that comply to required properties. Our focus in this paper is on architectural reasoning support for a single product instance. We illustrate the benefits of the approach by applying it to an example client-server system, and outline challenges for future work. © 2016 IEEE.
35.	Abbas, Nadeem, 1980-, et al. (author) Towards Autonomic Software Product Lines (ASPL) - A Technical Report 2011 Reports (other academic/artistic)abstract This report describes a work in progress to develop Autonomic Software Product Lines (ASPL). The ASPL is a dynamic software product line approach with a novel variability handling mechanism that enables traditional software product lines to adapt themselves at runtime in response to changes in their context, requirements and business goals. The ASPL variability mechanism is composed of three key activities: 1) context-profiling, 2) context-aware composition, and 3) online learning. Context-profiling is an offline activity that prepares a knowledge base for context-aware composition. The context-aware composition uses the knowledge base to derive a new product or adapts an existing product based on a product line's context attributes and goals. The online learning optimizes the knowledge base to remove errors and suboptimal information and to incorporate new knowledge. The three activities together form a simple yet powerful variability handling mechanism that learns and adapts a system at runtime in response to changes in system context and goals. We evaluated the ASPL variability mechanism on three small-scale software product lines and got promising results. The ASPL approach is, however, is yet at an initial stage and require improved development support with more rigorous evaluation.
36.	Abramian, David, 1992- (author) Modern multimodal methods in brain MRI 2023 Doctoral thesis (other academic/artistic)abstract Magnetic resonance imaging (MRI) is one of the pillars of modern medical imaging, providing a non-invasive means to generate 3D images of the body with high soft-tissue contrast. Furthermore, the possibilities afforded by the design of MRI sequences enable the signal to be sensitized to a multitude of physiological tissue properties, resulting in a wide variety of distinct MRI modalities for clinical and research use. This thesis presents a number of advanced brain MRI applications, which fulfill, to differing extents, two complementary aims. On the one hand, they explore the benefits of a multimodal approach to MRI, combining structural, functional and diffusion MRI, in a variety of contexts. On the other, they emphasize the use of advanced mathematical and computational tools in the analysis of MRI data, such as deep learning, Bayesian statistics, and graph signal processing. Paper I introduces an anatomically-adapted extension to previous work in Bayesian spatial priors for functional MRI data, where anatomical information is introduced from a T1-weighted image to compensate for the low anatomical contrast of functional MRI data. It has been observed that the spatial correlation structure of the BOLD signal in brain white matter follows the orientation of the underlying axonal fibers. Paper II argues about the implications of this fact on the ideal shape of spatial filters for the analysis of white matter functional MRI data. By using axonal orientation information extracted from diffusion MRI, and leveraging the possibilities afforded by graph signal processing, a graph-based description of the white matter structure is introduced, which, in turn, enables the definition of spatial filters whose shape is adapted to the underlying axonal structure, and demonstrates the increased detection power resulting from their use. One of the main clinical applications of functional MRI is functional localization of the eloquent areas of the brain prior to brain surgery. This practice is widespread for various invasive surgeries, but is less common for stereotactic radiosurgery (SRS), a non-invasive surgical procedure wherein tissue is ablated by concentrating several beams of high-energy radiation. Paper III describes an analysis and processing pipeline for functional MRI data that enables its use for functional localization and delineation of organs-at-risk for Elekta GammaKnife SRS procedures. Paper IV presents a deep learning model for super-resolution of diffusion MRI fiber ODFs, which outperforms standard interpolation methods in estimating local axonal fiber orientations in white matter. Finally, Paper V demonstrates that some popular methods for anonymizing facial data in structural MRI volumes can be partially reversed by applying generative deep learning models, highlighting one way in which the enormous power of deep learning models can potentially be put to use for harmful purposes.
37.	Adbo, Karina, et al. (author) Enantioselective synthetic receptors for Tröger’s base 1999 In: Bioorganic Chemistry. - : Academic Press. - 0045-2068. ; 27:5, s. 363-371 Journal article (peer-reviewed)
38.	Ahlford, Marianne, et al. (author) Uppsala Underdogs - A Robot Soccer Project 2006 Reports (pop. science, debate, etc.)abstract In this paper, we describe the four-legged soccer team Uppsala Underdogs developed by a group of 4th year computer science students at Uppsala University during the fall of 2004. The project is based on the experience from two similar previous projects. This year the emphasis of the project has been on distribution of data and on support for evaluation and reconfiguration of strategies. To support data distribution, a middleware has been developed, which implements a replication algorithm and provides a clean interface for the other software modules (or behaviors). To enable easy reconfiguration of strategies, an automata-based graphical description language has been developed, which can be compiled into code that uses the database and the lower level modules, such as tactics and positioning, to make decisions and control the robot. In addition, a graphical simulator has been developed in which the strategies can be evaluated.
39.	Ahrne, Göran, et al. (author) Ojämlikheten fördjupas i det svenska klassamhället 2021 In: Dagens Nyheter 2021-01-24. Journal article (pop. science, debate, etc.)
40.	Al-Dury, S., et al. (author) Catch-up antibody responses and hybrid immunity in mRNA vaccinated patients at risk of severe COVID-19 2023 In: Infectious Diseases. - 2374-4235. ; 55:10, s. 744-750 Journal article (peer-reviewed)abstract BackgroundThe immunogenicity of repeated vaccination and hybrid immunity in vulnerable patients remains unclear.MethodsWe studied the impact of iterative Covid-19 mRNA vaccination and hybrid immunity on antibody levels in immunosuppressed subjects. Patients with liver cirrhosis (n = 38), survivors of allogeneic haematopoietic stem cell transplantation (allo-HSCT) (n = 36) and patients with autoimmune liver disease (n = 14) along with healthy controls (n = 20) were monitored for SARS-CoV-2-S1 IgG after their 1st-3rd vaccine doses, 31 of whom became infected with the Omicron variant after the 2nd dose. Ten uninfected allo-HSCT recipients received an additional 4th vaccine dose.ResultsUnexpectedly, immunosuppressed patients achieved antibody levels in parity with controls after the 3rd vaccine dose. In all study cohorts, hybrid immunity (effect of vaccination and natural infection) resulted in approximately 10-fold higher antibody levels than vaccine-induced immunity alone.ConclusionsThree doses of the Covid-19 mRNA vaccine entailed high antibody concentrations even in immunocompromised individuals, and hybrid-immunity resulted further augmented levels than vaccination alone.
41.	Al-Saadi, Jonathan, et al. (author) Endovascular transplantation of mRNA-enhanced mesenchymal stromal cells results in superior therapeutic protein expression in swine heart 2024 In: Molecular therapy. Methods & clinical development. - : Elsevier BV. - 2399-6951 .- 2329-0501. ; 32:2 Journal article (peer-reviewed)abstract Heart failure has a poor prognosis and no curative treatment exists. Clinical trials are investigating gene- and cell-based therapies to improve cardiac function. The safe and efficient delivery of these therapies to solid organs is challenging. Herein, we demonstrate the feasibility of using an endovascular intramyocardial delivery approach to safely administer mRNA drug products and perform cell transplantation procedures in swine. Using a trans-vessel wall (TW) device, we delivered chemically modified mRNAs (modRNA) and mRNA-enhanced mesenchymal stromal cells expressing vascular endothelial growth factor A (VEGF-A) directly to the heart. We monitored and mapped the cellular distribution, protein expression, and safety tolerability of such an approach. The delivery of modRNA-enhanced cells via the TW device with different flow rates and cell concentrations marginally affect cell viability and protein expression in situ. Implanted cells were found within the myocardium for at least 3 days following administration, without the use of immunomodulation and minimal impact on tissue integrity. Finally, we could increase the protein expression of VEGF-A over 500-fold in the heart using a cell-mediated modRNA delivery system compared with modRNA delivered in saline solution. Ultimately, this method paves the way for future research to pioneer new treatments for cardiac disease.
42.	Aljaby, Ehab (red.), et al. (author) CLUSTERFUCK : Royal Institute of Art BA Graduation Show 2017 2017 Other publication (other academic/artistic)abstract This publication presents artworks and artists from the Royal Institute of Art BA Graduation Show in 2017.
43.	Amouzad Mahdiraji, Saeid (author) On the Use of Simulation and Optimization for the Analysis and Planning of Prehospital Stroke Care 2022 Licentiate thesis (other academic/artistic)abstract Immediate treatment is of extreme importance for stroke patients. However, providing fast enough treatment for stroke patients is far from trivial, mainly due to logistical challenges and difficulties in diagnosing the correct stroke type. One way to reduce the time to treatment is to use so-called Mobile Stroke Units (MSUs), which allows to diagnose and provide treatment for stroke patients already at the patient scene. A well-designed stroke transport policy is vital to improve the access to treatment for stroke patients. Simulation and mathematical optimization are useful approaches for assessing and optimizing stroke transport policies, without endangering the health of the patients.The main purpose of this thesis is to contribute to improving the situation for stroke patients and to reducing the social impacts of stroke. The aim is to study how to use simulation and optimization to achieve improved analysis and planning of prehospital stroke care. In particular, we focus on assessing the potential use of MSUs in a geographic area. In this thesis, optimization is used to identify the optimal locations of MSUs, and simulation is used to assess different stroke transport policies, including MSU locations. The results of this thesis aim to support public health authorities when making decisions in the prehospital stroke care domain.In order to fulfill the aim of this thesis, we develop and analyze a number of different simulation and optimization models. First, we propose a macro-level simulation model, an average time to treatment estimation model, used to estimate the expected time to treatment for different parts of a geographic region. Using the proposed model, we generate two different MSU scenarios to explore the potential benefits of employing MSUs in Sweden’s southern healthcare region (SHR). Second, we present an optimization model to identify the best placement of MSUs while making a trade-off between the efficiency and equity perspectives, providing maximum population coverage and equal service for all patients, respectively. The trade-off function used in the model makes use of the concepts of weighted average time to treatment to model efficiency and the time difference between the expected time to treatment for different geographical areas to model equity. In a scenario study applied in the SHR, we evaluate our optimization model by comparing the current situation with three MSU scenarios, including 1, 2, and 3 MSUs.Third, we present a micro-level discrete event simulation model to assess stroke transport policies, including MSUs, allowing us to model the behaviors of individual entities, such as patients and emergency vehicles, over time. We generate a synthetic set of stroke patients using a Poisson distribution, used as input in a scenario study.Finally, we present a modeling framework with reusable components, which aims to facilitate the construction of discrete event simulation models in the emergency medical services domain. The framework consists of a number of generic activities, which can be used to represent healthcare chains modeled in the form of flowcharts. As the framework includes activities and policies modeled on the general level, the framework can be used to create models only by providing input data and a care chain specification. We evaluate the framework by using it to build a model for simulating EMS activities related to the complex case of acute stroke.
44.	Andersson, Ann-Christine (author) Practice-based Improvements in Healthcare 2010 Licentiate thesis (other academic/artistic)abstract A central problem for the healthcare sector today is how to manage change and improvements. In recent decades the county councils in Sweden have started various improvement initiatives and programs in order to improve their healthcare services. The improvement program of the Kalmar county council, which constitutes the empirical context for this thesis, is one of those initiatives.The purpose of this thesis is to contribute to a broader understanding of large-scale improvement program in a healthcare setting. This is done by analyzing practitioner’s improvement ideas, describing participants in the improvement projects, revising and testing a survey to measure the development of improvement ideas and describing the improvement program from a theoretical perspective. The theoretical change model used looks at change from two opposing directions in six dimensions; Goals, Leadership, Focus, Process, Reward system and Use of consultants.The aims of the county council improvement program are to become a learning organization, disseminate improvement methodologies and implement continuous quality improvements in the organization. All healthcare administrations and departments in the county council were invited to apply for funds to accomplish improvement projects. Another initiative invited staff teams to work with improvement ideas in a program with support from facilitators, using the breakthrough methodology. Now almost all ongoing developments, improvements, patient safety projects, manager and leader development initiatives are put together under the county council improvement program umbrella.In the appended papers both qualitative and quantitative research approach were used. The first study (paper I) analyzed which types of improvement projects practitioners are engaged in using qualitative content analysis. Five main categories were identified: Organizational Process; Evidence and Quality; Competence Development; Process Technology; and Proactive Patient Work. Most common was a focus on organizational changes and process, while least frequent was proactive patient work. Besides these areas of focus, almost all aimed to increase patient safety and increase effectiveness and availability.Paper II described the participants in two of the initiatives, the categorized improvement projects in paper I and the team members in the methodology guided improvement programs. Strong professions like physicians and nurses were well represented, but other staff groups were not as active. Managers were responsible for a majority of the projects. The gender perspective reflected the overall mix of employees in the county council.Paper III described a revision and test of a Minnesota Innovation Survey (MIS) that will be used to follow and measure how quality improvement ideas develop and improve over time. Descriptive statistics were presented. The respondents were satisfied with their work and what they had accomplished. The most common comment was about time, not having enough time to work with the improvement idea and the difficulty of finding time because of regular tasks. This was the first test of the revised survey and the high use of the answer alternative “Do not know” showed that the survey did not fit the context very well in its present version.Trying to connect the county council improvement program and the initiatives studied in papers I and II with the change model gave rise to some considerations. The county council improvement program has an effort to combine organizational changes and a culture that encourages continuous improvements. Top-down and bottom-up management approaches are used, through setting out strategies from above and at the same time encouraging practitioners to improve their day-to-day work. Whether this will be a successful way to implement and achieve a continuous improvement culture in the whole organization is one of the main issues remaining to find out in further studies.
45.	Andersson, Anna, et al. (author) FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns. 2008 In: Genes, Chromosomes and Cancer. - 1045-2257. ; 47, s. 64-70 Journal article (peer-reviewed)abstract Abstract is not available
46.	Andersson, Anna, et al. (author) Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations 2005 In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 19:6, s. 1042-1050 Journal article (peer-reviewed)abstract Hematologic malignancies are characterized by fusion genes of biological/clinical importance. Immortalized cell lines with such aberrations are today widely used to model different aspects of leukemogenesis. Using cDNA microarrays, we determined the gene expression profiles of 40 cell lines as well as of primary leukemias harboring 11q23/MLL rearrangements, t(1;19)[TCF3/PBX1], t(12;21)[ETV6/RUNX1], t(8;21)[RUNX1/CBFA2T1], t(8;14) [IGH@/MYC], t(8;14)[TRA@/MYC], t(9;22)[BCR/ABL1], t(10;11) [PICALM/MLLT10], t(15;17)[PML/RARA], or inv(16)[CBFB/MYH11]. Unsupervised classification revealed that hematopoietic cell lines of diverse origin, but with the same primary genetic changes, segregated together, suggesting that pathogenetically important regulatory networks remain conserved despite numerous passages. Moreover, primary leukemias cosegregated with cell lines carrying identical genetic rearrangements, further supporting that critical regulatory pathways remain intact in hematopoietic cell lines. Transcriptional signatures correlating with clinical subtypes/primary genetic changes were identified and annotated based on their biological/molecular properties and chromosomal localization. Furthermore, the expression profile of tyrosine kinase-encoding genes was investigated, identifying several differentially expressed members, segregating with primary genetic changes, which may be targeted with tyrosine kinase inhibitors. The identified conserved signatures are likely to reflect regulatory networks of importance for the transforming abilities of the primary genetic changes and offer important pathogenetic insights as well as a number of targets for future rational drug design.
47.	Andersson, Anna, et al. (author) Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status. 2007 In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 21:6, s. 1198-1203 Journal article (peer-reviewed)abstract Gene expression analyses were performed on 121 consecutive childhood leukemias (87 B-lineage acute lymphoblastic leukemias (ALLs), 11 T-cell ALLs and 23 acute myeloid leukemias (AMLs)), investigated during an 8-year period at a single center. The supervised learning algorithm k-nearest neighbor was utilized to build gene expression predictors that could classify the ALLs/AMLs according to clinically important subtypes with high accuracy. Validation experiments in an independent data set verified the high prediction accuracies of our classifiers. B-lineage ALLs with uncharacteristic cytogenetic aberrations or with a normal karyotype displayed heterogeneous gene expression profiles, resulting in low prediction accuracies. Minimal residual disease status (MRD) in T-cell ALLs with a high (40.1%) MRD at day 29 could be classified with 100% accuracy already at the time of diagnosis. In pediatric leukemias with uncharacteristic cytogenetic aberrations or with a normal karyotype, unsupervised analysis identified two novel subgroups: one consisting mainly of cases remaining in complete remission (CR) and one containing a few patients in CR and all but one of the patients who relapsed. This study of a consecutive series of childhood leukemias confirms and extends further previous reports demonstrating that global gene expression profiling provides a valuable tool for genetic and clinical classification of childhood leukemias.
48.	Andersson, Arne, et al. (author) Suffix trees on words 1999 In: Algorithmica. ; 23 Journal article (peer-reviewed)abstract We discuss an intrinsic generalization of the suffix tree, designed to index a string of length n which has a natural partitioning into m multi-character substrings or words. This word suffix tree represents only the m suffixes that start at word boundaries. These boundaries are determined by delimiters, whose definition depends on the application.Since traditional suffix tree construction algorithms rely heavily on the fact that all suffixes are inserted, construction of a word suffix tree is nontrivial, in particular when only O(m) construction space is allowed. We solve this problem, presenting an algorithm with O(n) expected running time. In general, construction cost is Omega(n) due to the need of scanning the entire input. In applications that require strict node ordering, an additional cost of sorting O(m') characters arises, where m' is the number of distinct words. In either case, this is a significant improvement over previously known solutions.Furthermore, when the alphabet is small, we may assume that the $n$ characters in the input string occupy o(n) machine words. We illustrate that this can allow a word suffix tree to be built in sublinear time.
49.	Andersson, Andréa, et al. (author) The HIPC initiative and free trade in tobacco : a comparison of effetcs on the Malawi economy using a CGE model 2004 In: Journal of Development Alternatives and Area Studies. - 1651-9728. ; 23:3-4, s. 66-83 Journal article (peer-reviewed)
50.	Andersson, Anna, et al. (author) The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias. 2015 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:4, s. 192-330 Journal article (peer-reviewed)abstract Infant acute lymphoblastic leukemia (ALL) with MLL rearrangements (MLL-R) represents a distinct leukemia with a poor prognosis. To define its mutational landscape, we performed whole-genome, exome, RNA and targeted DNA sequencing on 65 infants (47 MLL-R and 18 non-MLL-R cases) and 20 older children (MLL-R cases) with leukemia. Our data show that infant MLL-R ALL has one of the lowest frequencies of somatic mutations of any sequenced cancer, with the predominant leukemic clone carrying a mean of 1.3 non-silent mutations. Despite this paucity of mutations, we detected activating mutations in kinase-PI3K-RAS signaling pathway components in 47% of cases. Surprisingly, these mutations were often subclonal and were frequently lost at relapse. In contrast to infant cases, MLL-R leukemia in older children had more somatic mutations (mean of 6.5 mutations/case versus 1.3 mutations/case, P = 7.15 × 10(-5)) and had frequent mutations (45%) in epigenetic regulators, a category of genes that, with the exception of MLL, was rarely mutated in infant MLL-R ALL.

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