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Sökning: WFRF:(Andersson Maria 1969 )

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1.
  • Andersson, Irene, 1978, et al. (författare)
  • Endothelial dysfunction in growth hormone transgenic mice
  • 2006
  • Ingår i: Clinical Science. - 0143-5221 .- 1470-8736. ; 110:2, s. 217-25
  • Tidskriftsartikel (refereegranskat)abstract
    • Acromegaly [overproduction of GH (growth hormone)] is associated with cardiovascular disease. Transgenic mice overexpressing bGH (bovine GH) develop hypertension and hypercholesterolaemia and could be a model for cardiovascular disease in acromegaly. The aims of the present study were to investigate the effects of excess GH on vascular function and to test whether oxidative stress affects endothelial function in bGH transgenic mice. We studied the ACh (acetylcholine)-induced relaxation response in aortic and carotid rings of young (9-11 weeks) and aged (22-24 weeks) female bGH transgenic mice and littermate control mice, without and with the addition of a free radical scavenger {MnTBAP [Mn(III)tetrakis(4-benzoic acid)porphyrin chloride]}. We also measured mRNA levels of eNOS (endothelial nitric oxide synthase) and EC-SOD (extracellular superoxide dismutase). Intracellular superoxide anion production in the vascular wall was estimated using a dihydroethidium probe. Carotid arteries from bGH transgenic mice had an impaired ACh-induced relaxation response (young, 46 +/- 7% compared with 69 +/- 8%; aged, 52 +/- 5% compared with 80 +/- 3%; P < 0.05), whereas endothelial function in aorta was intact in young but impaired in aged bGH transgenic mice. Endothelial dysfunction was corrected by addition of MnTBAP in carotid arteries from young mice and in aortas from aged mice; however, MnTBAP did not correct endothelial dysfunction in carotid arteries from aged bGH transgenic mice. There was no difference in intracellular superoxide anion production between bGH transgenic mice and control mice, whereas mRNA expression of EC-SOD and eNOS was increased in aortas from young bGH transgenic mice compared with control mice (P < 0.05). We interpret these data to suggest that bGH overexpression is associated with a time- and vessel-specific deterioration in endothelial function, initially caused by increased oxidative stress and later by other alterations in vascular function.
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2.
  • Andersson, Anders, et al. (författare)
  • Effects of Tobacco Smoke on IL-16 in CD8+ Cells from Human Airways and Blood: a Key Role for Oxygen Free Radicals?
  • 2011
  • Ingår i: AJP - Lung cellular and molecular physiology. - : American Physiological Society. - 1522-1504. ; 300:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Chronic exposure to tobacco smoke leads to an increase in the frequency of infections and in CD8(+) and CD4(+)cells as well as the CD4(+) chemo-attractant cytokine IL-16 in the airways. Here, we investigated whether tobacco smoke depletes intracellular IL-16 protein and inhibits de novo production of IL-16 in CD8(+) cells from human airways and blood, while at the same time increasing extracellular IL-16 and whether oxygen free radicals (OFR) are involved. Intracellular IL-16 protein in CD8(+) cells and mRNA in all cells was decreased in bronchoalveolar lavage (BAL) samples from chronic smokers. This was also the case in human blood CD8(+) cells exposed to water-soluble tobacco smoke components in vitro; in which oxidized proteins were markedly increased. Extracellular IL-16 protein was increased in cell-free BAL fluid from chronic smokers and in human blood CD8(+) cells exposed to water-soluble tobacco smoke components in vitro. This was not observed in occasional smokers after short-term exposure to tobacco smoke. A marker of activation (CD69) was slightly increased whereas other markers of key cellular functions (membrane integrity, apoptosis and proliferation) in human blood CD8(+) cells in vitro were negatively affected by water-soluble tobacco smoke components. An OFR scavenger prevented these effects whereas a protein synthesis inhibitor, a beta-adrenoceptor, a glucocorticoid receptor agonist, a phosphodiesterase, a calcineurin phosphatase and a caspase-3 inhibitor did not. In conclusion, tobacco smoke depletes preformed intracellular IL-16 protein, inhibits its de novo synthesis and distorts key cellular functions in human CD8(+) cells. OFR may play a key role in this context.
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4.
  • Gravina, Giacomo, et al. (författare)
  • Survivin in autoimmune diseases.
  • 2017
  • Ingår i: Autoimmunity reviews. - : Elsevier BV. - 1873-0183 .- 1568-9972. ; 16:8, s. 845-855
  • Forskningsöversikt (refereegranskat)abstract
    • Survivin is a protein functionally important for cell division, apoptosis, and possibly, for micro-RNA biogenesis. It is an established marker of malignant cell transformation. In non-malignant conditions, the unique properties of survivin make it indispensable for homeostasis of the immune system. Indeed, it is required for the innate and adaptive immune responses, controlling differentiation and maintenance of CD4(+) and CD8(+) memory T-cells, and in B cell maturation. Recently, survivin has emerged as an important player in the pathogenesis of autoimmune diseases. Under the conditions of unreserved inflammation, survivin enhances antigen presentation, maintains persistence of autoreactive cells, and supports production of autoantibodies. In this context, survivin takes its place as a diagnostic and prognostic marker in rheumatoid arthritis, psoriasis, systemic sclerosis and pulmonary arterial hypertension, neuropathology and multiple sclerosis, inflammatory bowel diseases and oral lichen planus. In this review, we summarise the knowledge about non-malignant properties of survivin and focus on its engagement in cellular and molecular pathology of autoimmune diseases. The review highlights utility of survivin measures for clinical applications. It provides rational for the survivin inhibiting strategies and presents results of recent reports on survivin inhibition in modern therapies of cancers and autoimmune diseases.
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5.
  • Hipkiss, Anna Maria, et al. (författare)
  • Teaching in Flexible Spatial and Digital Conditions
  • 2021
  • Ingår i: EARLI 2021. ; , s. 314-314
  • Konferensbidrag (refereegranskat)abstract
    • This study explores the opportunities and challenges of teaching under flexible spatial and digital conditions of the learning environment of a newly build school, analyzing how teaching is organized and what curricular genres can be discerned, what resources and practices are offered to stimulate students meaningmaking and what framing, relations and accessibility can be distinguished by the flexibility of furniture and classroom space. The analyses of a teacher team’s planning and teaching of the thematic work project on Space in years 2-3 (ages 8 to 9) and another teacher team’s thematic work project onCommunication in years 4-7 (ages10 to12) reveal varied teaching strategies between teacher-led and student-centered forms offering students linguistic, visual and audiovisual resources to make meaning of shared content in different school subjects. The young students practice reading comprehension, both of written texts and films, that also serves their knowledge-building about space. The older students display skills relating to different subjects through different technological and digital resources. 
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6.
  • Hjalmarsson, Clara, 1969, et al. (författare)
  • Neuronal and glia-related biomarkers in cerebrospinal fluid of patients with acute ischemic stroke
  • 2014
  • Ingår i: Journal of Central Nervous System Disease. - 1179-5735. ; 19:6, s. 51-8
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Cerebral ischemia promotes morphological reactions of the neurons, astrocytes, oligodendrocytes, and microglia in experimental studies. Our aim was to examine the profile of CSF (cerebrospinal fluid) biomarkers and their relation to stroke severity and degree of white matter lesions (WML). METHODS: A total of 20 patients (mean age 76 years) were included within 5-10 days after acute ischemic stroke (AIS) onset. Stroke severity was assessed using NIHSS (National Institute of Health stroke scale). The age-related white matter changes (ARWMC) scale was used to evaluate the extent of WML on CT-scans. The concentrations of specific CSF biomarkers were analyzed. RESULTS: Patients with AIS had significantly higher levels of NFL (neurofilament, light), T-tau, myelin basic protein (MBP), YKL-40, and glial fibrillary acidic protein (GFAP) compared with controls; T-Tau, MBP, GFAP, and YKL-40 correlated with clinical stroke severity, whereas NFL correlated with severity of WML (tested by Mann-Whitney test). CONCLUSIONS: Several CSF biomarkers increase in AIS, and they correlate to clinical stroke severity. However, only NFL was found to be a marker of degree of WML.
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7.
  • Pirazzi, Carlo, et al. (författare)
  • PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
  • 2014
  • Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:15, s. 4077-4085
  • Tidskriftsartikel (refereegranskat)abstract
    • Retinoids are micronutrients that are stored as retinyl esters in the retina and hepatic stellate cells (HSCs). HSCs are key players in fibrogenesis in chronic liver diseases. The enzyme responsible for hydrolysis and release of retinyl esters from HSCs is unknown and the relationship between retinoid metabolism and liver disease remains unclear. We hypothesize that the patatin-like phospholipase domain-containing 3 (PNPLA3) protein is involved in retinol metabolism in HSCs. We tested our hypothesis both in primary human HSCs and in a human cohort of subjects with non-alcoholic fatty liver disease (N = 146). Here we show that PNPLA3 is highly expressed in human HSCs. Its expression is regulated by retinol availability and insulin, and increased PNPLA3 expression results in reduced lipid droplet content. PNPLA3 promotes extracellular release of retinol from HSCs in response to insulin. We also show that purified wild-type PNPLA3 hydrolyzes retinyl palmitate into retinol and palmitic acid. Conversely, this enzymatic activity is markedly reduced with purified PNPLA3 148M, a common mutation robustly associated with liver fibrosis and hepatocellular carcinoma development. We also find the PNPLA3 I148M genotype to be an independent (P = 0.009 in a multivariate analysis) determinant of circulating retinol-binding protein 4, a reliable proxy for retinol levels in humans. This study identifies PNPLA3 as a lipase responsible for retinyl-palmitate hydrolysis in HSCs in humans. Importantly, this indicates a potential novel link between HSCs, retinoid metabolism and PNPLA3 in determining the susceptibility to chronic liver disease.
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8.
  • Sandahl, Johan, 1974-, et al. (författare)
  • Överdrivna slutsatser om gymnasieelevers demokratikunskaper
  • 2022
  • Ingår i: Skola & Samhälle [S.O.S] Webbtidskrift. - : Föreningen Skola & Samhälle - webbtidskrift. - 2001-6727.
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Rapporten från Stiftelsen Rättsfonden om gymnasieelevers kunskaper om demokrati har både metodologiska och teoretiska brister. Eftersom rapporten saknar stöd för flera av de rekommendationer som lämnas är risken att föreslagna förändringar inte gör någon skillnad eller i värsta fall leder i fel riktning, skriver Johan Sandahl med flera, alla forskare i samhällsvetenskapernas didaktik.
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10.
  • Sofkova Hashemi, Sylvana, 1969-, et al. (författare)
  • Tema, rum och digitalisering i ny skolverksamhet : Slutrapport från projektet Digiflex Didaktisk Design i Samverkan
  • 2023
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Sveriges befolkning ökar och med det följer om- och nybyggnation av skolor med förväntningar på innovativa skolmiljöer som erbjuder god arbetsmiljö för elever och lärare och främjar en modern, elevcentrerad och elevaktiv pedagogik. Detta projekt var baserat i en sådan nybyggd skola som erbjuder flexibilitet i variation av rum och öppna ytor, flyttbara möbler och digital teknologi i sin utformning.Syftet med projektet har varit att utveckla förståelse för den nybyggda skolans lärmiljö och studera hur skolans flexibla rumsliga och digitala ramar påverkar lärares undervisning och elevers kunskapsutveckling med utgångspunkt i följande frågeställningar:1. Hur används skolans fysiska och digitala rum i lärares undervisningsdesign?2. Hur kan elevers kunskapsutveckling stöttas genom rumslig och digital undervisningsdesign?3. Hur utnyttjas fysiska och digitala rum för att lyckas med det kompensatoriska uppdraget?Projektets har tillämpat co-design metoder, en kombination av aktionsforskning och design-baserad forskning, där lärare och forskare systematiskt och tillsammans studerat förändring och utveckling av undervisning i skolans lärmiljö över tid. Projektet har fokuserat på lärares didaktiska planering, undervisning och reflektion, möblering och rörelse i och mellan rummen, användning av digitala resurser, anpassning till elever samt ledarskapets roll. I utvecklingen av undervisningsdesign ingick kollegial planering, uppföljning, reflektion och re-design av undervisning i workshopsformat utifrån en tidigare utvecklad meta-tänkande modell för didaktisk design kallad Tanketärningar. Undervisningsdesignen har prövats i småskaliga interventioner och studerats genom observationer av lärares och elevers praktiker. En återkommande enkät har använts för att fånga lärarnas individuella röster. Dessutom genomfördes samtal och intervjuer med lärare och ledare på skolan.Resultaten visar på att skolans flexibla rumsliga och digitala lärmiljö ställer nya krav på lärare att tänka organisatoriskt runt elevflöden och digitala resurser i undervisningen. Lärares varierande rumsliga inramningar av undervisningen mellan fri rörlighet och statiska arrangemang ger möjligheter till olika relationsbyggande. Skolans goda digitala infrastruktur erbjuder lärarna ett multimodalt planeringsstöd och flexibilitet i feedback och anpassning av innehåll till eleverna. Dock kan den digitala undervisningen även framkalla hårt paketerad och ”klicka-sig-fram” undervisning som minskar lärares handlingsutrymme och elevinflytande. Lärare skolar in elever till en strukturerad flexibilitet för att hantera rumslig och digital variation som uppfattas även ge utrymme att möta eleverna individuellt när andra elever i gruppen arbetar mer självständigt. Samtidigt är inte lärmiljön anpassad för elever som kräver en högre grad av didaktiskt ledarskap.Samverkansambitioner har utmanats under projektets gång av coronapandemin men också oregelbundenheten i möten utöver workshoppar. Personalomsättning har påverkat relationsbygget mellan lärare och forskare över tid. Verksamhetens kollegiala arbete i lärarlag och ämnesövergripande undervisning utifrån ett fokus på tematiskt arbete har visat sig utmana lärarrollen, främst i de högre årskurserna. Projektets resultat pekar tydligt på vikten av kollegial samsyn och ledarskapets roll i det pedagogiska arbetet. Flexibiliteten behöver tolkas och kräver omfattande kollektiv planering i lärarlag som behöver ges tid och handlingsutrymme.Projektets resultat har spridits kontinuerligt genom skolans webbsida, vetenskapliga publikationer, presentationer och workshoppar på forskningskonferenser, föredrag i Göteborgs stad som listas i slutet på rapporten. En film har samproducerats om arbetet med tanketärningsmodellen. Under projektets gång producerades sex examensarbeten på lärarutbildningarna och en masteruppsats inom informatik. Masteruppsatsen skrevs om till ett vetenskapligt prisbelönt bidrag.
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11.
  • Sofkova Hashemi, Sylvana, 1969, et al. (författare)
  • Tema, rum och digitalisering i ny skolverksamhet. Slutrapport från ULF-projektet DigiFLEX: Didaktisk design i samverkan
  • 2023
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Sveriges befolkning ökar och med det följer om- och nybyggnation av skolor med förväntningar på innovativa skolmiljöer som erbjuder god arbetsmiljö för elever och lärare och främjar en modern, elevcentrerad och elevaktiv pedagogik. Detta projekt var baserat i en sådan nybyggd skola som erbjuder flexibilitet i variation av rum och öppna ytor, flyttbara möbler och digital teknologi i sin utformning. Syftet med projektet har varit att utveckla förståelse för den nybyggda skolans lärmiljö och studera hur skolans flexibla rumsliga och digitala ramar påverkar lärares undervisning och elevers kunskapsutveckling med utgångspunkt i följande frågeställningar: 1. Hur används skolans fysiska och digitala rum i lärares undervisningsdesign? 2. Hur kan elevers kunskapsutveckling stöttas genom rumslig och digital undervisningsdesign? 3. Hur utnyttjas fysiska och digitala rum för att lyckas med det kompensatoriska uppdraget? Projektets har tillämpat co-design metoder, en kombination av aktionsforskning och design-baserad forskning, där lärare och forskare systematiskt och tillsammans studerat förändring och utveckling av undervisning i skolans lärmiljö över tid. Projektet har fokuserat på lärares didaktiska planering, undervisning och reflektion, möblering och rörelse i och mellan rummen, användning av digitala resurser, anpassning till elever samt ledarskapets roll. I utvecklingen av undervisningsdesign ingick kollegial planering, uppföljning, reflektion och re-design av undervisning i workshopsformat utifrån en tidigare utvecklad meta-tänkande modell för didaktisk design kallad Tanketärningar. Undervisningsdesignen har prövats i småskaliga interventioner och studerats genom observationer av lärares och elevers praktiker. En återkommande enkät har använts för att fånga lärarnas individuella röster. Dessutom genomfördes samtal och intervjuer med lärare och ledare på skolan. Resultaten visar på att skolans flexibla rumsliga och digitala lärmiljö ställer nya krav på lärare att tänka organisatoriskt runt elevflöden och digitala resurser i undervisningen. Lärares varierande rumsliga inramningar av undervisningen mellan fri rörlighet och statiska arrangemang ger möjligheter till olika relationsbyggande. Skolans goda digitala infrastruktur erbjuder lärarna ett multimodalt planeringsstöd och flexibilitet i feedback och anpassning av innehåll till eleverna. Dock kan den digitala undervisningen även framkalla hårt paketerad och ”klicka-sig-fram” undervisning som minskar lärares handlingsutrymme och elevinflytande. Lärare skolar in elever till en strukturerad flexibilitet för att hantera rumslig och digital variation som uppfattas även ge utrymme att möta eleverna individuellt när andra elever i gruppen arbetar mer självständigt. Samtidigt är inte lärmiljön anpassad för elever som kräver en högre grad av didaktiskt ledarskap. Samverkansambitioner har utmanats under projektets gång av coronapandemin men också oregelbundenheten i möten utöver workshoppar. Personalomsättning har påverkat relationsbygget mellan lärare och forskare över tid. Verksamhetens kollegiala arbete i lärarlag och ämnesövergripande undervisning utifrån ett fokus på tematiskt arbete har visat sig utmana lärarrollen, främst i de högre årskurserna. Projektets resultat pekar tydligt på vikten av kollegial samsyn och ledarskapets roll i det pedagogiska arbetet. Flexibiliteten behöver tolkas och kräver omfattande kollektiv planering i lärarlag som behöver ges tid och handlingsutrymme. Projektets resultat har spridits kontinuerligt genom skolans webbsida, vetenskapliga publikationer, presentationer och workshoppar på forskningskonferenser, föredrag i Göteborgs stad som listas i slutet på rapporten. En film har samproducerats om arbetet med tanketärningsmodellen. Under projektets gång producerades sex examensarbeten på lärarutbildningarna och en masteruppsats inom informatik. Masteruppsatsen skrevs om till ett vetenskapligt prisbelönt bidrag. Mer information om projektet: www.gu.se/forskning/digiflex
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12.
  • Taube, Magdalena, et al. (författare)
  • Evaluation of reference genes for gene expression studies in human brown adipose tissue.
  • 2015
  • Ingår i: Adipocyte. - : Informa UK Limited. - 2162-3945 .- 2162-397X. ; 4:4, s. 280-5
  • Tidskriftsartikel (refereegranskat)abstract
    • Human brown adipose tissue (BAT) has during the last 5 year been subjected to an increasing research interest, due to its putative function as a target for future obesity treatments. The most commonly used method for molecular studies of human BAT is the quantitative polymerase chain reaction (qPCR). This method requires normalization to a reference gene (genes with uniform expression under different experimental conditions, e.g. similar expression levels between human BAT and WAT), but so far no evaluation of reference genes for human BAT has been performed. Two different microarray datasets with samples containing human BAT were used to search for genes with low variability in expression levels. Seven genes (FAM96B, GNB1, GNB2, HUWE1, PSMB2, RING1 and TPT1) identified by microarray analysis, and 8 commonly used reference genes (18S, B2M, GAPDH, LRP10, PPIA, RPLP0, UBC, and YWHAZ) were selected and further analyzed by quantitative PCR in both BAT containing perirenal adipose tissue and subcutaneous adipose tissue. Results were analyzed using 2 different algorithms (Normfinder and geNorm). Most of the commonly used reference genes displayed acceptably low variability (geNorm M-values <0.5) in the samples analyzed, but the novel reference genes identified by microarray displayed an even lower variability (M-values <0.25). Our data suggests that PSMB2, GNB2 and GNB1 are suitable novel reference genes for qPCR analysis of human BAT and we recommend that they are included in future gene expression studies of human BAT.
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13.
  • Öhrn, Maria, et al. (författare)
  • Productivity, Satisfaction, Work Environment and Health after Relocation to an Activity-Based Flex Office : The Active Office Design Study
  • 2021
  • Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 18:14
  • Tidskriftsartikel (refereegranskat)abstract
    • Implementation of activity-based flex offices (AFOs) are becoming increasingly common. The aim of this study was to evaluate the effects of an AFO on perceived productivity, satisfaction, work environment and health. Questionnaire data from the longitudinal, quasi-experimental Active Office Design Study was used. The study evaluates a public organization relocating staff to either an AFO or to cell offices. Measures from baseline, 6 and 18 months after relocation, were analyzed. Employees in the AFO experienced a decreased productivity and satisfaction with the office design. Lack of privacy as well as increased noise disturbance, less satisfaction with sit comfort and work posture were reported. Employees in the AFO with work tasks requiring a high degree of concentration experienced lower productivity while those with a high proportion of teamwork rated productivity to be continually high. No significant group differences were found between the two office types in general health, cognitive stress, salutogenic health indicators or pain in the neck, shoulder or back. The study highlights the importance of taking work characteristics into account in the planning and implementation process of an AFO. Flexible and interactive tasks seem more appropriate in an AFO, whereas individual tasks demanding concentration seem less fit.
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15.
  • Andersson, Anna, et al. (författare)
  • Development and validation of experienced work-integrated learning instrument (E-WIL) using a sample of newly graduated registered nurses : A confirmatory factor analysis
  • 2023
  • Ingår i: Nurse Education Today. - 0260-6917 .- 1532-2793. ; 128, s. 1-9
  • Tidskriftsartikel (refereegranskat)abstract
    • INTRODUCTION: Research indicates that newly graduated registered nurses struggle to develop practical skills and clinical understanding and to adapt to their professional role. To ensure quality of care and support new nurses, it is vital that this learning is elucidated and evaluated. Aim The aim was to develop and evaluate the psychometric properties of an instrument assessing work-integrated learning for newly graduated registered nurses, the Experienced Work-Integrated Learning (E-WIL) instrument.METHOD: The study utilized the methodology of a survey and a cross-sectional research design. The sample consisted of newly graduated registered nurses (n = 221) working at hospitals in western Sweden. The E-WIL instrument was validated using confirmatory factor analysis (CFA).RESULTS: The majority of the study participants were female, the average age was 28 years, and participants had an average of five months' experience in the profession. The results confirmed the construct validity of the global latent variable E-WIL, "Transforming previous notions and new contextual knowledge into practical meaning," including six dimensions representing work-integrated learning. The factor loadings between the final 29 indicators and the six factors ranged from 0.30 to 0.89, and between the latent factor and the six factors from 0.64 to 0.79. The indices of fit indicated satisfactory goodness-of-fit and good reliability in five dimensions with values ranging from α = 0.70 to 0.81, except for one dimension showing a slightly lower reliability, α = 0.63, due to the low item number. Confirmatory factor analysis also confirmed two second-order latent variables, "Personal mastering of professional roles" with 18 indicators, and "Adapting to organisational requirements" with 11 indicators. Both showed satisfactory goodness-of-fit, and factor loading between indicators and the latent variables ranged from 0.44 to 0.90 and from 0.37 to 0.81, respectively.CONCLUSION: The validity of the E-WIL instrument was confirmed. All three latent variables could be measured in their entirety, and all dimensions could be used separately for the assessment of work-integrated learning. The E-WIL instrument could be useful for healthcare organisations when the goal is to assess aspects of newly graduated registered nurses' learning and professional development.
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16.
  • Andersson, Anna (författare)
  • Ett öppet klassrumsklimat är viktigt för elevers demokratilärande
  • 2023
  • Ingår i: Skolforskningsportalen. - Stockholm : Skolforskningsinstitutet.
  • Annan publikation (populärvet., debatt m.m.)abstract
    • Skolan har ett viktigt demokratiuppdrag och undervisningens utformning påverkar elevers lärande. Ett öppet klassrumsklimat där elever bjuds in att fråga, diskutera och komma med synpunkter på ämnesinnehållet är det i särklass viktigaste för att skapa förutsättningar för demokratilärande – oavsett skolämne.
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20.
  • Andersson, Erik, et al. (författare)
  • Political Participation as Public Pedagogy : The Educational Situation in Young People’s Political Conversations in Social Media
  • 2014
  • Ingår i: Journal of Social Science Education. - 1618-5293. ; 13:4, s. 115-126
  • Tidskriftsartikel (refereegranskat)abstract
    • In this article we argue that young people’s political participation in the social media can be considered ‘public pedagogy’. The argument builds on a previous empirical analysis of a Swedish net community called Black Heart. Theoretically, the article is based on a particular notion of public pedagogy, education and Hannah Arendt’s expressive agonism. The political participation that takes place in the net community builds up an educational situation that involves central characteristics: communication, community building, a strong content focus and content production, argumentation and rule following. These characteristics pave the way for young people’s public voicing, experiencing, preferences and political interests that guide their everyday political life and learning – a phenomenon that we understand as a form of public pedagogy. 
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21.
  • Andersson, Karin, 1972, et al. (författare)
  • Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment.
  • 2015
  • Ingår i: Molecular medicine (Cambridge, Mass.). - : Springer Science and Business Media LLC. - 1528-3658 .- 1076-1551. ; 21, s. 536-43
  • Tidskriftsartikel (refereegranskat)abstract
    • T-helper cells producing interleukin (IL)-17A and IL-17F cytokines (Th17 cells) are considered the source of autoimmunity in rheumatoid arthritis (RA). In this study, we characterized specific pathogenic features of Th17 cells in RA. By using nano-string technology, we analyzed transcription of 419 genes in the peripheral blood CCR6(+)CXCR3(-) CD4(+) cells of 14 RA patients and 6 healthy controls and identified 109 genes discriminating Th17 cells of RA patients from the controls. Th17 cells of RA patients had an aggressive pathogenic profile and in addition to signature cytokines IL-17, IL-23 and IL-21, and transcriptional regulators RAR-related orphan receptor gamma of T cells (RORγt) and Janus kinase 2 (JAK2), they produced high levels of IL-23R, C-C chemokine ligand type 20 (CCL20), granulocyte-monocyte colony-stimulating factor (GM-CSF ) and transcription factor Tbet required for synovial homing. We showed that Th17 cells are enriched with Helios-producing Foxp3- and IL2RA-deficient cells, indicating altered regulatory profile. The follicular T-helper (Tfh) cells presented a functional profile of adaptor molecules, transcriptional regulator Bcl-6 and B-cell activating cytokines IL-21, IL-31 and leukemia inhibitory factor (LIF ). We observed that anti-tumor necrosis factor (TNF) treatment had a limited effect on the transcription signature of Th17 cells. Patients in remission retained the machinery of receptors (IL-23R and IL-1R1), proinflammatory cytokines (IL-17F, IL-23, IL-21 and TNF ) and adaptor molecules (C-X-C chemokine receptor 5 [CXCR5] and cytotoxic T-lymphocyte-associated protein 4 [CTLA-4]), essential for efficient transdifferentiation and accumulation of Th17 cells. This study convincingly shows that the peripheral blood CCR6(+)CXCR3(-) CD4(+) cells of RA patients harbor pathogenic subsets of Th17 and Tfh cells, which may transdifferentiate from Tregs and contribute to perpetuation of the disease.
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22.
  • Andersson, Karin, 1972, et al. (författare)
  • Survivin controls biogenesis of microRNA in smokers: A link to pathogenesis of rheumatoid arthritis.
  • 2017
  • Ingår i: Biochimica et biophysica acta. - : Elsevier BV. - 0006-3002. ; 1863:3, s. 663-673
  • Tidskriftsartikel (refereegranskat)abstract
    • MicroRNAs (miRs) represent a part of epigenetic control of autoimmunity gaining increasing attention in rheumatoid arthritis (RA). Since cigarette smoking plays important role in RA pathogenesis and reprograms transcriptional profile of miRNAs, we ask if the onco-protein survivin, a novel biomarker of RA, may provide a link between smoking and miRNA. Studying survivin expression in leukocytes of 144 female RA patients we observed that smoking patients had higher survivin transcription and a remarkable spreading of survivin isoforms. This was associated with restricted pattern and low production of miRs. Additionally, miRNA processing enzymes Dicer and DGRC8 were decreased in the patients with survivin isoform spreading. The direct contribution of survivin in miRs biogenesis was confirmed by a massive increase of miRs production following inhibition of survivin in leukocyte cultures. Dicer is shown to mediate these effects of survivin. Chromatin immunoprecipitation analysis demonstrated binding of survivin to the Dicer promoter region. Dicer expression increased 5-folds following survivin inhibition. Taken together, this study presents experimental evidence of a novel cellular function of survivin, control of miRs biogenesis. Up-regulation of survivin in smokers suggests its role as effector of the adverse epigenetic control in RA.
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23.
  • Andersson, Linda, 1969-, et al. (författare)
  • Economic man and the consumption of addictive goods : the case of two goods
  • 2006
  • Ingår i: Substance Use & Misuse. - New York : Dekker. - 1082-6084 .- 1532-2491. ; 41, s. 453-466
  • Tidskriftsartikel (refereegranskat)abstract
    • It is well known that cigarette smoking and the use of other addictive goods is harmful to health. Still, some people smoke cigarettes and drink alcohol in their daily lives. The consumption of addictive goods seems, therefore, to be the antithesis of rational behavior. In this article, however, it is demonstrated that a rational individual, in the sense that he or she maximizes his or her well-being while anticipating the future consequences of his or her choices, may in fact choose to consume addictive goods. Specifically, the two-good extension of the rational addiction model is demonstrated and related to relevant policy questions. For instance, should one encourage the use of smokeless tobacco in smoking cessation programs? According to the empirical results, the answer is no. Further, should one discourage smoking by increasing the tax on cigarettes? Again, the answer is no.
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24.
  • Andersson, Maria, 1977, et al. (författare)
  • A Social-Psychological Perspective on Herding in Stock Markets
  • 2014
  • Ingår i: The Journal of Behavioral Finance. - : Informa UK Limited. - 1542-7560 .- 1542-7579. ; 15:3, s. 226-234
  • Tidskriftsartikel (refereegranskat)abstract
    • A social-psychological perspective conceives of herding in stock markets as informative social influence resulting from heuristic or systematic information processing. In three laboratory experiments employing undergraduates we apply this perspective to investigate factors that prevent herd influence that would lead to inaccurate predictions of stock prices. In Experiment 1 we show that an economic reward for making the same predictions as the herd increases the influence of a majority but not the influence of a minority, and that an individual economic reward for making accurate predictions reduces the influence of the majority. In Experiment 2 we show a reduced influence of a majority herd’s inaccurate predictions when requiring assessments of the accuracy of the majority herd´s predictions as compared to requiring judgments of their consistency. Experiment 3 shows that a lower volatility of stock prices reduces the influence of a majority herd´s inaccurate predictions
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25.
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26.
  • Andersson, Maria, 1969-, et al. (författare)
  • Critical care nurses’ perception of moral distress in intensive care during the COVID-19 pandemic – A pilot study
  • 2022
  • Ingår i: Intensive & Critical Care Nursing. - : Elsevier. - 0964-3397 .- 1532-4036. ; 72
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: To describe critical care nurses’ perception of moral distress during the second year of the COVID-19 pandemic.Design/Methods: A cross-sectional study involving a questionnaire was conducted. Participants responded to the Italian version of the Moral Distress Scale-Revised, which consists of 14 items divided in dimensions Futile care (three items), Ethical misconduct (five items), Deceptive communication (three items) and Poor teamwork (three items). For each item, participants were also invited to write about their experiences and participants’ intention to leave a position now was measured by a dichotomous question. The data were analysed with descriptive statistics and qualitative content analysis. The study followed the checklist (CHERRIES) for reporting results of internet surveys.Setting: Critical care nurses (n = 71) working in Swedish adult intensive care units.Results: Critical care nurses experienced the intensity of moral distress as the highest when no one decided to withdraw ventilator support to a hopelessly ill person (Futile care), and when they had to assist another physician or nurse who provided incompetent care (Poor teamwork). Thirty-nine percent of critical care nurses were considering leaving their current position because of moral distress.Conclusions: During the COVID-19 pandemic, critical care nurses, due to their education and experience of intensive care nursing, assume tremendous responsibility for critically ill patients. Throughout, communication within the intensive care team seems to have a bearing on the degree of moral distress. Improvements in communication and teamwork are needed to reduce moral distress among critical care nurses.
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27.
  • Andersson, Maria, 1975, et al. (författare)
  • Differential global gene expression response patterns of human endothelium exposed to shear stress and intraluminal pressure
  • 2005
  • Ingår i: J Vasc Res. - : S. Karger AG. - 1018-1172. ; 42:5, s. 441-52
  • Tidskriftsartikel (refereegranskat)abstract
    • We investigated the global gene expression response of endothelium exposed to shear stress and intraluminal pressure and tested the hypothesis that the two biomechanical forces induce a differential gene expression response pattern. Intact living human conduit vessels (umbilical veins) were exposed to normal or high intraluminal pressure, or to low or high shear stress in combination with a physiological level of the other force in a unique vascular ex vivo perfusion system. Gene expression profiling was performed by the Affymetrix microarray technology on endothelial cells isolated from stimulated vessels. Biomechanical forces were found to regulate a very large number of genes in the vascular endothelium. In this study, 1,825 genes were responsive to mechanical forces, which corresponds to 17% of the expressed genes. Among pressure-responsive genes, 647 genes were upregulated and 519 genes were down regulated, and of shear stress-responsive genes, 133 genes were upregulated and 771 down regulated. The fraction of genes that responded to both pressure and shear stimulation was surprisingly low, only 13% of the regulated genes. Our results indicate that the two different stimuli induce distinct gene expression response patterns, which can also be observed when studying functional groups. Considering the low number of overlapping genes, we suggest that the endothelial cells can distinguish between shear stress and pressure stimulation.
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28.
  • Andersson, Maria, 1977, et al. (författare)
  • Effects of consistency and accurate predictions of stock prices on herding in a simulated financial market.
  • 2008
  • Ingår i: Poster presented at the 29th annual conference of the Society for Judgment and Decision Making, Chicago, USA..
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • In a simulated financial market setting we investigate the degree to which participants in judgment tasks were influenced by other (fictitious) participants’ judgments. Two experiments examine the influence from random vs. accurate majorities (Experiment 1), random vs. accurate minorities (Experiment 2), and whether the influence was affected by instructing participants to focus on the accuracy in performance (Experiments 1 and 2). Results show that participants followed majorities irrespectively of their level of accuracy, whereas accurate minorities were more influential than random minorities. The focus instruction decreased majority influence, regardless of accuracy, but increased the influence from accurate minorities.
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29.
  • Andersson, Maria, 1977, et al. (författare)
  • Effects of financial incentives on herding in simulated financial markets
  • 2008
  • Ingår i: Paper presented at the International Association for Research in Economic Psychology (IAREP), Rome, Italy..
  • Konferensbidrag (refereegranskat)abstract
    • Herding in financial markets refers to that investors influence each other when making investment decisions. In these experimental studies, herding leads to worse performance relative to relying on private information. Previous studies of herding have shown that majorities in general are more influential than minorities. The aim of this research was to investigate whether financial incentives impact herding with majorities and minorities under these conditions. In two experimental simulations of a financial market, participants predicted an “upmarket” or “downmarket” conditional on diagnostic information presented on each trial. In Experiment 1, participants in an individual condition only received private information, while participants in a group condition, in addition, received information about randomly generated predictions ostensibly made by three others. Economic incentives for accurate predictions were based on individual performance, and were hypothesized to counteract reliance on invalid information about the herd’s choices. As expected, performance was worse in the group condition than in the individual condition, implying that participants were influenced by the herd. In Experiment 2, the effects of financial incentives for making predictions similar to either the majority or the minority of the others were examined. We hypothesized that financially rewarding group performance may reinforce non-systematic processing, and hence enhance majority influence. Since minority influence is associated with systematic processing, we hypothesized that systematic processing in minority conditions may increase the influence of the private information, and thus improve performance. The results showed that participants followed the majority but not the minority. One explanation for the asymmetry in the effects of rewarding herding with a majority and a minority may be the notion that the tendency to conform overrides systematic processing in majority influence, whereas the reverse would be true in minority influence.
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30.
  • Andersson, Maria, 1977, et al. (författare)
  • Effects of stock investments of information about short versus long price series
  • 2012
  • Ingår i: Review of behavioral finance. - : Emerald. - 1940-5979. ; 4:2, s. 81-97
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose – The purpose of this paper is to investigate whether stock price predictions and investment decisions improve by exposure to increasing price series. Design/methodology/approach – The authors conducted three laboratory experiments in which undergraduates were asked to role-play being investors buying and selling stock shares. Their task was to predict an unknown closing price from an opening price and to choose the number of stocks to purchase to the opening price (risk aversion) or the closing price (risk taking). In Experiment 1 stock prices differed in volatility for increasing, decreasing or no price trend. Prices were in different conditions provided numerically for 15 trading days, for the last 10 trading days, or for the last five trading days. In Experiment 2 the price series were also visually displayed as scatter plots. In Experiment 3 the stock prices were presented for the preceding 15 days, only for each third day (five days) of the preceding 15 days, or as five prices, each aggregated for three consecutive days of the preceding 15 days. Only numerical price information was provided. Findings – The results of Experiments 1 and 2 showed that predictions were not markedly worse for shorter than longer price series. Possibly because longer price series increase information processing load, visual information had some influence to reduce prediction errors for the longer price series. The results of Experiment 3 showed that accuracy of predictions increased for less price volatility due to aggregation, whereas again there was no difference between five and 15 trading days. Purchase decisions resulted in better outcomes for the aggregated prices. Research limitations/implications – Investors´ performance in stock markets may not improve by increasing the length of evaluation intervals unless the quality of the information is also increased. The results need to be verified in actual stock markets. Practical implications – The results have bearings on the design of bonus systems. Originality/value – The paper shows how stock price predictions and buying and selling decisions depend on amount and quality of information about historical prices.
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31.
  • Andersson, Maria, 1980, et al. (författare)
  • Enhanced concentrations of dissolved gaseous mercury in the surface waters of the Arctic Ocean
  • 2008
  • Ingår i: Marine Chemistry. - : Elsevier BV. - 0304-4203. ; 110:3-4, s. 190-194
  • Tidskriftsartikel (refereegranskat)abstract
    • During an almost three months long expedition in the Arctic Ocean, the Beringia 2005, dissolved gaseous mercury (DGM) was measured continuously in the surface water. The DGM concentration was measured using an equilibrium system, i.e. the DGM in the water phase equilibrated with a stream of gas and the gas was thereafter analysed with respect to its mercury content. The DGM concentrations were calculated using the following equation, DGM = Hg eq / k H' where Hg eq is the equilibrated concentration of elemental mercury in the gas phase and k H' is the dimensionless Henry's law constant at desired temperature and salinity. During the expedition several features were observed. For example, enhanced DGM concentration was measured underneath the ice which may indicate that the sea ice acted as a barrier for evasion of mercury from the Arctic Ocean to the atmosphere. Furthermore, elevated DGM concentrations were observed in water that might have originated from river discharge. The gas-exchange of mercury between the ocean and the atmosphere was calculated in the open water and both deposition and evasion were observed. The measurements showed significantly enhanced DGM concentrations, compared to more southern latitudes. © 2008 Elsevier B.V. All rights reserved.
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32.
  • Andersson, Maria, 1977, et al. (författare)
  • Experimental Studies of Majority Influences in Financial Markets.
  • 2008
  • Ingår i: Paper presented at the 6th Nordic conference on group and social psychology (GRASP), Lund University, Sweden.
  • Konferensbidrag (refereegranskat)abstract
    • Herding in financial markets refers to that investors imitate others when making investment decisions. The aim of this research is to investigate factors that would break influences of a majority of others. In one experiment we investigate the impact of the size of a herd (majority vs. minority), accuracy of the herds’ predictions, and attentional focus. Undergraduates serving as participants are asked to predict fictitious stock prices in 50 trials, conditional on information about the current price and predictions made by five fictitious other participants. The prices and the others’ predictions are generated by random sampling. A majority of the others’ predictions is correlated (rs .95), and the predictions made by the majority are either random (uncorrelated with the price, r <.20) or accurate (correlated with the price, range of rs equal to .65 - .85). Participants are instructed to focus their attention on either accuracy or consistency of the others’ predictions. The results showed that a focus on accuracy reduced majority influence, whereas a focus on consistency had no effect. This was true both in the conditions with accurate and inaccurate majorities. An ongoing additional experiment investigates whether an accurate minority has an influence when its predictions have higher predictive validity than the price. The level of accuracy in the predictions made by the minority is either random (uncorrelated with the price, r <.20) or accurate (correlated with the price, rs .95).
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33.
  • Andersson, Maria, 1969-, et al. (författare)
  • Good in Providing Oral Care, but we Could be Better-Nursing Staff Identification of Improvement Areas in Oral Care
  • 2021
  • Ingår i: Sage Open Nursing. - : Sage Publications. - 2377-9608. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Oral care to older people in short-term care units is a complex and challenging everyday practice for nursing staff. Oral care research and knowledge about prerequisites and obstacles is extensive. However, there is a lack of knowledge about how nursing staff in short-term care units describe their satisfaction about provided oral care in order to maintain older people's oral health. Objective: The purpose of this study was to describe how nursing staff perceive their satisfaction of oral care provided for older people in short-term care units and to identify oral care improvements. Methods: This study reports on the results of two open-ended questions that were part of a larger study. Informants (n = 54) were nursing staff working in the involved short-term care units in municipalities from both densely and sparsely populated regions in central and northern Sweden. The answers to the open-ended questions were analyzed using content analysis. Results: The analysis yielded one main category; "Working together to improve satisfaction with older people's oral care" and four subcategories: "Older people's oral health," " Consideration and respect for the older person's autonomy," "Having access to adequate products," and "Working together in the same direction." Conclusion: Identification of older people's oral health problems together with adequate nursing intervention will increase older people's health outcomes and quality of life. However, regardless of work role, the nursing staff might have difficulty changing their behavior or transforming intentions into actions. Oral care is a complicated and proactive practice that requires nursing staff's attention as well as both educational and organizational initiatives. Working in a supportive and collaborative relationship provides prerequisites for optimal oral care in short-term care units.
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34.
  • Andersson, Maria, 1977, et al. (författare)
  • Hållbara bonussystem : Sustainable bonus systems
  • 2011
  • Ingår i: Hållbar utveckling - från risk till värde / L. G. Hassel, L.-O. Larsson & E. Nore (red.). - Malmö : Studentlitteratur. - 9789144075327 ; , s. 41-49
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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35.
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36.
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37.
  • Andersson, Maria, 1969-, et al. (författare)
  • Intensive care nurses fail to translate knowledge and skills into practice : A mixed-methods study on perceptions of oral care
  • 2019
  • Ingår i: Intensive & Critical Care Nursing. - : Elsevier. - 0964-3397 .- 1532-4036. ; 52, s. 51-60
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: To identify intensive care nurses’ perceptions of oral care according to Coker et al.'s (2013) conceptual framework and to contribute to the knowledge base of oral care in intensive care. Design/methods: This was a concurrent embedded mixed-methods design, with more weight given to the quantitative part. Participants responded to the Nursing Care related to Oral Health questionnaire, including perceptions of oral care antecedents (18 items), defining attributes (17 items), and consequences (6 items) and two open-ended questions. The data were analysed with descriptive and correlation statistics and qualitative content analysis. Setting: Intensive care nurses (n = 88) in six general intensive care units. Results: Intensive care nurses perceived that an important part of nursing care was oral care, especially to intubated patients. They perceived that the nursing staff was competent in oral care skills and had access to different kinds of equipment and supplies to provide oral care. The oral cavity was inspected on a daily basis, mostly without the use of any assessment instruments. Oral care seemed to be task-oriented, and documentation of the patients’ experiences of the oral care process was rare. Conclusions: The antecedents, knowledge and skills are available to provide quality oral care, but intensive care nurses seem to have difficulties translating these components into practice. Thus they might have to shift their task-oriented approach towards oral care to a more person-centred approach in order to be able to meet patients’ needs. © 2018 Elsevier Ltd
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38.
  • Andersson, Maria, 1976, et al. (författare)
  • Mild renal ischemia-reperfusion reduces charge and size selectivity of the glomerular barrier
  • 2007
  • Ingår i: American Journal of Physiology Renal Physiology. - : American Physiological Society. - 0363-6127 .- 1931-857X .- 1522-1466. ; 292:6
  • Tidskriftsartikel (refereegranskat)abstract
    • Despite recent discoveries of molecules in podocytes, the mechanisms behind most conditions of proteinuria are still poorly understood. To understand more about this delicate barrier, we studied the functional and morphological effects of mild (15 min) renal ischemia-reperfusion injury (IRI). Renal function was studied in rats in vivo, followed by a more detailed analysis of the glomerular barrier in cooled (8 degrees C) isolated perfused kidneys (cIPK). Renal blood flow was quickly restored, whereas the glomerular filtration rate remained halved 30 min after IRI. Tubular cell activity was intact as judged from the unaffected Cr-EDTA U/P concentration ratio. In vivo, the fractional clearance (theta) for albumin increased 16 times. In rats subjected to cIPK starting 30 min after in vivo IRI, theta(albumin) was 15 times and theta(Ficoll_36angstroms) 1.8 times higher than in control cIPKs. According to the heterogeneous charged fiber model, IRI reduced the fiber charge density to 38% of control (P < 0.01, n = 7). Morphometric analysis with electron microscopy did not reveal any changes in the podocytes or the glomerular basement membrane (GBM) after IRI, suggesting more subtle changes of the GBM and/or the endothelial glycocalyx. We conclude that mild renal IRI induces formation of reactive oxygen species, massive proteinuria, and loss of charged fibers with no apparent change in morphology. These novel findings stress the importance of other components of the barrier, such as proteoglycans produced by the glomerular cells, and provide a tentative explanation for the mechanisms behind proteinuria in glomerulonephritis, for example.
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39.
  • Andersson, Maria, 1969-, et al. (författare)
  • Moral Distress, Health and Intention to Leave: Critical Care Nurses’ Perceptions During COVID-19 Pandemic
  • 2023
  • Ingår i: Sage Open Nursing. - : SAGE Publications Inc.. - 2377-9608. ; 9
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Moral distress increases the risk that critical care nurses will lose the ability to provide quality nursing care.Aims: To describe person-related conditions and perceptions of moral distress, health and intention to leave among critical care nurses in intensive care units, and to examine the relationship between person-related conditions, moral distress, health and intention to leave.Method: Cross-sectional, with 220 critical care nurses in 15 Swedish ICUs, and data gathered via a self-reported questionnaire.Results: Highest moral distress scores were reported in futile care and poor teamwork and 21% reported entertaining an intention to leave. Self-reported health was lower than before the COVID-19 pandemic and 4.1% reported pronounced exhaustion disorder. Self-reported health, reduced capacity to tolerate demands under time pressure, emotional instability or irritability, physical weakness, or being more easily fatigued and with decreased well-being were factors that had a relationship with futile care. Sleeping problems and intention to leave had a relationship with poor teamwork.Conclusions: Different strategies are needed to reduce moral distress and the leadership is crucial for managing crises such as the COVID-19 pandemic.
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40.
  • Andersson, Maria, 1969-, et al. (författare)
  • Older people's perceptions of the quality of oral care in short-term care units : A cross-sectional study
  • 2018
  • Ingår i: International Journal of Older People Nursing. - : John Wiley & Sons. - 1748-3735 .- 1748-3743. ; 13:2, s. 1-14
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: There is a lack of knowledge about oral care among older people living in short-term care (STC) units and how the quality of oral care provided by nursing staff is perceived by the older people. Aim: To (i) describe person-related conditions among older people in STC, (ii) describe and compare perceptions of the quality of oral care (including perceptions of care received and the subjective importance of such care), within and between older people who have the ability to perform oral self-care and those who are dependent on help with oral care and (iii) examine the relationship between person-related conditions and the quality of oral care. Methods: A cross-sectional study was conducted with 391 older people in STC units in Sweden based on self-reported questionnaire and clinical assessments. Results: The older people were assessed as having normal oral health (2%), moderate oral health problems (78%) or severe oral health problems (20%). When comparing older people's perceptions of quality of oral care in terms of perceived reality and subjective importance, significant differences appeared within and between groups. Psychological well-being had a significant relationship with perception of the quality of oral care (both perceived reality and subjective importance), and gender and oral health status had a significant relationship with subjective importance. Conclusions: Older people's perceptions of areas for improvement regarding quality of oral care is a new and important knowledge for nursing staff in STC units. Older people want personalised information regarding oral health and oral care. Registered Nurses who take the responsibility in nursing care for older people's oral health may avoid unnecessary suffering by older people caused by oral health problems. Implications for practice: Older people's perspective is an important component for quality work and might lead to improvements in the quality of oral care in STC. © 2018 John Wiley & Sons Ltd.
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41.
  • Andersson, Maria, 1969-, et al. (författare)
  • Oral care : identifying quality improvement areas
  • 2019
  • Ingår i: International Journal of Health Care Quality Assurance. - : Emerald Group Publishing Limited. - 0952-6862 .- 1758-6542. ; 32:1, s. 45-58
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: To describe and compare nurses' and healthcare assistants' oral care qualityperceptions, including perceived reality and subjective importance, to identify improvementareas in intensive care and short-term care, and to explore potential nursing satisfactionpredictors regarding oral care.Design/methodology/approach: Swedish staff, 154 within intensive care and 278 withinshort-term care responded to a modified Quality of Care from a Patient Perspectivequestionnaire. Descriptive and analytical statistics were used.Findings: Staff scored oral care quality both high and low in relation to perceived reality andsubjective importance. Improvement areas were identified, despite high satisfaction valuesregarding oral care. Setting, subjective importance, and perceived reality explained 51.5% ofthe variance in staff satisfaction regarding oral care quality.Practical implications: Quality improvements could guide oral care development.Originality/value: This study describes oral care by comparing nurse perceptions of howimportant they perceive different oral care aspects and to what extent these oral care aspectsare performed.
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42.
  • Andersson, Maria, 1969-, et al. (författare)
  • Oral care quality - do humanity aspects matter? : Nursing staff and older people's perspectives
  • 2020
  • Ingår i: Nursing Open. - : John Wiley & Sons. - 2054-1058. ; 7:3, s. 857-868
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim (a) To describe and compare perceptions of humanity aspects of oral care quality in relation to nursing staff in short-term care units and intensive care units and older people in short-term care units and their person-related conditions; and (b) to compare humanity aspects of oral care quality perceptions between nursing staff and older people in short-term care units. Design Cross-sectional study. Self-reported questionnaire and clinical assessments. Methods Nursing staff (N = 417) and older people (N = 74) completed the modified Quality of Care from a Patient Perspective instrument and person-related items. Older people's oral health status was clinically assessed using the Revised Oral Assessment Guide. Data were analysed using descriptive and analytic statistics. The data were collected from 2013-2016. Results Nursing staff's perceptions of humanity aspects of oral care quality were related to gender, work role and care environment. Older people's perceptions of humanity aspects of oral care quality were related to self-reported physical health. Nursing staff in short-term care units perceived the subjective importance of humanity aspects of oral care quality higher compared with older people in short-term care units.
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43.
  • Andersson, Maria, 1969- (författare)
  • Oral care quality in intensive care units and short-term care units : Nursing staff and older people's perspectives
  • 2019
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The overall aim of this thesis was to investigate oral care and its quality through the perspectives of nursing staff in intensive care units and short-term care units and from the perspectives of older people in short-term care units. Methods: The mix-method study (I) had a concurrent embedded design and was cross-sectional. Eighty-eight intensive care nurses (response rate (RR) 40%) responded to the Nursing Care related to Oral Health questionnaire, and the data were analysed with analytic statistics and qualitative content analysis. The quantitative studies (II-IV), which were also cross-sectional, included 432 nursing staff in intensive care and short-term care (RR 51–52%) and 391 older people (RR 77%) in short-term care units. Participants responded to the modified version of the Quality from Patients’ Perspective instrument and provided information about person-related conditions. Descriptive and analytical statistics were used. Main results: Intensive care nurses perceived having the antecedents, knowledge, and skills to provide optimal oral care quality, but the result indicated that they were having difficulties putting these into practice (I). Areas for improvement in oral care quality were identified in both care environments (II). Older people preferred personalised information about oral health and oral care (III). Nursing staff as well as older people’s perceptions of oral care quality and its humanity aspects, seemed to be related to person-related conditions and differed between the two care environments. In short-term care, nursing staff’s preferences for the humanity aspects of oral care quality were higher compared to older people’s preferences (IV). Conclusion: Oral care is complicated and proactive and requires registered nurses’ and other nursing staff’s attention as well as educational and organisational initiatives. Many older people were assessed to have oral health problems. With early identification and optimal oral care, unnecessary suffering might be prevented. The identified quality improvement areas might guide RNs, nurse managers, and other nursing staff to further oral care quality development.
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44.
  • Andersson, Maria, 1969-, et al. (författare)
  • Patient photographs-A landmark for the ICU staff : A descriptive study.
  • 2013
  • Ingår i: Intensive & Critical Care Nursing. - : Elsevier BV. - 0964-3397 .- 1532-4036. ; 29:4, s. 193-201
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: The purpose of this study was to investigate ICU staff's perceptions of photographs displayed at the bedsides of unconscious patients and whether profession, years in ICU and work status had any influence on these perceptions.RESEARCH METHODOLOGY: A cross-sectional study was used comprising a questionnaire with statements and one open-ended question. All registered nurses, enrolled nurses and anaesthetists working in one ICU in Sweden were included. A total of 85 participants returned a questionnaire (response rate=77%).RESULTS: The findings of the study revealed that a photograph of the patient helped the ICU staff to relate to the patient as a person. Profession, years in ICU and work status had influence on the ICU staff's perceptions. From the content analysis two categories emerged: "getting closer and see the person" and "a landmark bringing hope".CONCLUSION: The ICU staff need to consider how close to the patient they want to be and why the patient's recovery is worth striving for. Keeping a professional approach is one of the challenges of working in ICU. A photograph can be an inexpensive and easy way of preventing the loss of identity of the patient as an individual within the technocratic environments of the ICU.
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45.
  • Andersson, Magnus, et al. (författare)
  • Peer review of laboratory reports for engineering students
  • 2018
  • Ingår i: European Journal of Engineering Education. - : Taylor & Francis. - 0304-3797 .- 1469-5898. ; , s. 1-12
  • Tidskriftsartikel (refereegranskat)abstract
    • Here, we present a module to introduce student peer review of laboratoryreports to engineering students. Our findings show that students werepositive and felt that they had learnt quite a lot from this experience.The most important part of the module was the classification scheme.The scheme was constructed to mimic the way an expert would arguewhen making a fair judgement of a laboratory report. Hence, our resultsmay suggest that the success of the module design comes from activelyengaging students in work that is more related to ‘arguing like anexpert’ than to only supply feedback to peers, which in such a casewould implicate a somewhat new direction for feedback research. Forpractitioners, our study suggests that important issues to consider in thedesign are (i) a clear and understandable evaluation framework, (ii)anonymity in the peer-review process and (iii) a small external motivation.
  •  
46.
  • Andersson, Maria, 1969- (författare)
  • Philosophical knowledge is warranted for the successful implementation of person-centred care
  • 2021
  • Ingår i: Nordic journal of nursing research. - : Sage Publications. - 2057-1585 .- 2057-1593. ; 41:3, s. 117-120
  • Tidskriftsartikel (refereegranskat)abstract
    • One potentially restrictive environment of person-centred care might be the intensive care unit (ICU) where RNs working inICUs on a daily basis are caring for critically ill patients in a highly technological and stressful milieu. Nursing care for critically illpatients at the ICU is described as task-oriented and mainly based on the patient’s medical needs. The purpose of thiscontemporary issue paper is to suggest that a photograph of the patient could be used as a tool to support RNs workingin ICU in applying person-centred care and their understanding of the philosophical underpinnings for person-centred care. Iadditionally propose that philosophical understanding and knowledge among RNs working in ICU are an essential part of clinicalpractice if person-centred care implementations are to be sustainable.
  •  
47.
  • Andersson, Maria, 1977, et al. (författare)
  • Social influence on predictions of simulated stock prices
  • 2009
  • Ingår i: Journal of Behavioral Decision Making. ; 22, s. 271-279
  • Tidskriftsartikel (refereegranskat)abstract
    • Herding in financial markets refers to that investors are influenced by others. This study addresses the importance of consistency for herding. It is suggested that, in financial markets perceptions of consistency are based on repeated observations over time. Consistency may then be perceived as the agreement across time between investors’ predictions. In addition, consistency may be related to variance over time in each investor’s predictions. In an experiment using a Multiple Cue Probability Learning paradigm, 96 undergraduates made multi-trial predictions of future stock prices given information about the current price and the predictions made by five fictitious others. Consistency was varied between the others' predictions (correlation) and within the others’ predictions (variance). The results showed that the predictions were significantly influenced by the others’ predictions when these were correlated. No effect of variance was observed. Hence, participants were influenced by the others when they were in agreement, regardless of whether they varied their predictions over trials or not.
  •  
48.
  • Andersson, Maria, 1977, et al. (författare)
  • The effect of accuracy and focus on herding in financial predictions.
  • 2008
  • Ingår i: Paper presented at the 10th meeting of the European Social Cognition Network (ESCON), Volterra, Italy..
  • Konferensbidrag (refereegranskat)abstract
    • Herding in financial markets refers to that investors influence each other when making investment decisions. Previous studies of herding have shown that a majority is more influential than a minority. This result is in line with theories of social influence, arguing that majorities in general are more influential but consistent minorities may also exert influence. The aim of this research is to investigate what factors may impact the level of influence from minorities and majorities in financial markets, focusing on accuracy and focal attention. Experiment 1 investigates the impact of the size of the herd (majority vs. minority) and the accuracy in its predictions. Participants’ task was to predict fictitious stock prices in 50 trials, conditional on information about the current price and predictions made by five fictitious other participants. Either four (majority) or two (minority) of the others’ predictions were correlated (rs > .95), and they made either random (uncorrelated with the price trend, rs < .20) or non-random predictions (correlated with the price trend, range of rs equal to .65 to .85). The results showed that the majority exerted more influence than did the minority, more when the majority made non-random than random predictions. The correlation and accuracy of predictions thus increased the majority influence, but not the minority influence. The aim of Experiment 2 was to investigate whether the majority influence would decrease if participants were instructed to focus on the others’ performance. Conditions in which the majority made random or non-random predictions were included. After a number of trials participants were requested to state either which of the others that made accurate predictions or which of the others that made predictions that were correlated. The results showed that focus on accuracy reduced majority influence.
  •  
49.
  • Andersson, Maria, 1976-, et al. (författare)
  • The implementation of a Free-choice Market System in Swedish Community Mental Health Services by the Example of Day Centres
  • 2014
  • Ingår i: Jubilee Congress 50 years WASP World Association of Social Psychiatry, London, November 13-15, 2014..
  • Konferensbidrag (refereegranskat)abstract
    • Marketization in community mental health services is a new phenomenon and might be the most comprehensive reform in the field since the deinstitutionalisation that occurred during the second half of the twentieth century. Historically, mental health services have been characterized by discipline and paternalistic practices.There has been an absence ofwhat is now, due to the new organizational model based on individual freedom of choice, is to be introduced. The aim of this study was to investigate the implementation of a free-choice market system in community mental health services, using the example of day centres for people with psychiatric disabilities. The study was conducted in a major city that was about to implement a free-choice market system due to a new legislation. Eighteen semi-structured interviews were conducted. Agents situated in different parts of the organization were interviewed one year before and two years after the free-choice system was launched in 2010. Data showed a top-down political process. The policy intentions of the new Act were in focus when studying the relation between policy and practice during the implementation process. A majority of the policy intentions of the new Act advocated individual autonomy as the market system’s main purpose, only one intention concerned organizational efficiency. Interview data reflected, however, that financial efficiency dominated the agents’ experiences of the implemented system. The twofold market purpose was clearly reflected in the interviews. Front-line staff hoped for improvements mainly for the users, when managers mainly focused on the market as a resource allocator.
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50.
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