| 1. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 2. |
- Dima, Danai, et al.
(författare)
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Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3-90 years.
- 2022
-
Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 452-469
-
Tidskriftsartikel (refereegranskat)abstract
- Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
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| 3. |
- Fazey, Ioan, et al.
(författare)
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Transforming knowledge systems for life on Earth : Visions of future systems and how to get there
- 2020
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Ingår i: Energy Research & Social Science. - : Elsevier. - 2214-6296 .- 2214-6326. ; 70
-
Tidskriftsartikel (refereegranskat)abstract
- Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of progress being made in stimulating the societal changes needed to address challenges like climate change. In this research we used a novel futures-oriented and participatory approach that asked what future envisioned knowledge systems might need to look like and how we might get there. Findings suggest that envisioned future systems will need to be much more collaborative, open, diverse, egalitarian, and able to work with values and systemic issues. They will also need to go beyond producing knowledge about our world to generating wisdom about how to act within it. To get to envisioned systems we will need to rapidly scale methodological innovations, connect innovators, and creatively accelerate learning about working with intractable challenges. We will also need to create new funding schemes, a global knowledge commons, and challenge deeply held assumptions. To genuinely be a creative force in supporting longevity of human and non-human life on our planet, the shift in knowledge systems will probably need to be at the scale of the enlightenment and speed of the scientific and technological revolution accompanying the second World War. This will require bold and strategic action from governments, scientists, civic society and sustained transformational intent.
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| 4. |
- Frangou, Sophia, et al.
(författare)
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Cortical thickness across the lifespan : Data from 17,075 healthy individuals aged 3-90 years
- 2022
-
Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 431-451
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Tidskriftsartikel (refereegranskat)abstract
- Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
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| 5. |
- Andersson-Engels, Stefan, et al.
(författare)
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In vivo luminescence imaging and tomography using upconverting nanoparticles as contrast agents
- 2012
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Ingår i: 2012 Asia Communications and Photonics Conference. - 2162-108X. ; , s. 2-3
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Konferensbidrag (refereegranskat)abstract
- Upconverting nanoparticles have recently drawn increasingly attention as contrast agents for optical bioimaging. They enable autofluorescence-free imaging within the tissue optical window, and improved spatial resolution as compared to conventional fluorescence-based contrast agents. (C) 2012 Optical Society of America
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| 6. |
- Andersson, Staffan, 1959, et al.
(författare)
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Multiple receivers, multiple ornaments, and a trade-off between agonistic and epigamic signaling in a widowbird.
- 2002
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Ingår i: The American naturalist. - : University of Chicago Press. - 1537-5323 .- 0003-0147. ; 160:5, s. 683-91
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Tidskriftsartikel (refereegranskat)abstract
- Sexual displays often involve several different ornamental traits. Yet most indicator models of sexual selection based on a single receiver (usually a choosy female) find that multiple handicap signals should be unstable. Here we study reasons for this contradiction, analyzing signal function, signal content, and trade-offs between signals in the polygynous red-collared widowbird Euplectes ardens. Males have both a long, graduated tail and a red carotenoid collar badge. Territory-holding "residents" have slightly shorter tails than the nonbreeding "floaters," but their carotenoid collars are 40% larger, and they have (on the basis of reflectance spectrometry and objective colorimetry) a 23-nm more long-wave ("redder") hue than floaters. This corroborates experimental evidence that the red collar is selected by male contest competition, whereas female choice is based almost exclusively on male tail length. Tail length is negatively correlated with the carotenoid signal, which together with body size and condition explains 55% of the variation in tail length. The trade-off in tail length and carotenoid investment is steeper among residents, suggesting an interaction with costs of territory defense. We propose that the "multiple receiver hypothesis" can explain the coexistence of multiple handicap signals. Furthermore, the trade-off between signal expressions might contribute to the inverse relation between nuptial tail elongation and coloration in the genus Euplectes (bishops and widowbirds).
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| 7. |
- Hanzén, Sarah, et al.
(författare)
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Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins
- 2016
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Ingår i: Cell. - : Elsevier BV. - 0092-8674. ; 166:1, s. 140-151
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Tidskriftsartikel (refereegranskat)abstract
- Caloric restriction (CR) extends the lifespan of flies, worms, and yeast by counteracting age-related oxidation of H2O2-scavenging peroxiredoxins (Prxs). Here, we show that increased dosage of the major cytosolic Prx in yeast, Tsa1, extends lifespan in an Hsp70 chaperone-dependent and CR-independent manner without increasing H2O2 scavenging or genome stability. We found that Tsa1 and Hsp70 physically interact and that hyperoxidation of Tsa1 by H2O2 is required for the recruitment of the Hsp70 chaperones and the Hsp104 disaggregase to misfolded and aggregated proteins during aging, but not heat stress. Tsa1 counteracted the accumulation of ubiquitinated aggregates during aging and the reduction of hyperoxidized Tsa1 by sulfiredoxin facilitated clearance of H2O2-generated aggregates. The data reveal a conceptually new role for H2O2 signaling in proteostasis and lifespan control and shed new light on the selective benefits endowed to eukaryotic peroxiredoxins by their reversible hyperoxidation.
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| 8. |
- Adielsson, Stina, et al.
(författare)
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Resultat från miljöövervakningen av bekämpningsmedel (växtskyddsmedel) : Långtidsöversikt 2002-2008. Årssammanställning 2008
- 2009. - 2009:115
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rapporten presenterar resultaten från övervakningen av växtskyddsmedel i ytvatten, grundvatten, sediment och regnvatten i Sverige under åren 2002-2008. Undersökningen genomförs inom ramen för den nationella miljöövervakningen på uppdrag av Naturvårdsverket (Jordbruksmark och Luft). Tidigare resultat har sammanställts i enskilda årsrapporter. Detta är första gången som resultaten har sammanställts för en längre tidsperiod (7 år), vilket ger ett underlag för att spegla utvecklingen över tiden.Övervakningen av ytvatten omfattas av provtagningar i fyra typområden (Västergötland, Figur 2; Östergötland, Figur 5; Halland, Figur 8; Skåne, Figur 11) och två åar i Skåne (Skivarpsån och Vege å). Ytvattenprovtagningen står för den största andelen av alla enskilda analyser under perioden (ca 60 000). Provtagningarna i typområdena sker tidsintegrerat med hjälp av automatiska provtagare och i åarna tas manuella momentanprov. I typområdena har även provtagning av grundvatten och sediment genomförts. Regnvatten undersöks vid en lokal på Söderåsen i Skåne.Antalet substanser som har analyserats varierar mellan provtyperna och i viss mån även mellan åren. Detta som en följd av att vissa substanser försvinner från marknaden och nya tillkommer. Även analysgränsen har förändrats under åren, främst för några substanser där den sänkts för att bättre motsvara de riktvärden som introducerats under tidsperioden.Inom varje typområde samlas det varje år in omfattande informaion om grödval och vilka växtskyddsmedel som används. Även information om nederbörd och avrinning samlas in kontinuerligt. Denna information utgör ett värdefullt underlag vid tolkningen av resultaten.
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| 9. |
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| 10. |
- Aguilar, Mónica García, et al.
(författare)
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Governance challenges and opportunities for implementing resource recovery from organic waste streams in urban areas of Latin America: insights from Chía, Colombia
- 2022
-
Ingår i: Sustainable Production and Consumption. - : Elsevier. - 2352-5509. ; 30, s. 53-63
-
Tidskriftsartikel (refereegranskat)abstract
- Across the globe, there is increasing interest in implementing circular approaches to urban sanitation and waste management to mitigate environmental challenges and promote sustainable business opportunities. In Latin America where 80% of the population live in urban areas, there is limited investigation into the enabling factors and governance barriers that are critical to implementing circular economy strategies in urban areas. This paper aims at assessing the governance capacity to implement resource recovery from organic waste streams in the municipality of Chía, Colombia, through applying the Governance Capacity Framework in a participatory process with local stakeholders. The findings highlight the importance of local initiatives for resource recovery that allow experimentation, raise awareness and foster collaboration, as well as mechanisms available for public participation in decision-making processes as enabling factors. Meanwhile, the inadequate monitoring and assessment of environmental strategies and policies, inadequate sharing of information among stakeholders and the relative low awareness of potential benefits of recovering resources from organic waste streams, especially among public sector actors, emerge as key barriers. Beyond Chía, the results provide insights on crucial factors for ensuring sufficient governance capacity in other urban areas in low- and middle-income countries which are considering circular approaches to urban sanitation and waste management. The findings also provide an empirical basis to advance the understanding of the governance conditions necessary for implementing resource recovery from organic waste streams, upon which further applications of the governance capacity framework along with participatory aspects in other similar urban contexts could build.
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| 11. |
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| 12. |
- Andersson, Ingegärd, et al.
(författare)
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Speciation in vanadium bioinorganic systems 6. Speciation study of aqueous peroxovanadates, including complexes with imidazole
- 2000
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Ingår i: Journal of Inorganic Biochemistry. ; 80:1-2, s. 51-8
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Tidskriftsartikel (refereegranskat)abstract
- Using a combination of potentiometry (glass electrode) and quantitative 51V NMR spectroscopy, the full speciation in the vanadate–peroxide and vanadate–peroxide–imidazole systems was determined in the pH range 1–10 (0.150 M Na(Cl) medium, 25 °C). Using the computer program LAKE, the pKa value of imidazole and the formation constants for 10 peroxovanadate species and also for three more species where a single imidazole moiety is also bound, have been calculated. The experimental data show a good fit to the calculated speciation model, even for the less abundant species. The species are either monomeric or dimeric in vanadium, and four resonances of the dimeric species have been unambiguously assigned via 2D 51V NMR. Diperoxovanadates are the favoured species at pH 2–10, when sufficient peroxide is present. Imidazole is found to bind strongly to them at pH 6–9. The equilibrium conditions are illustrated in distribution diagrams.
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| 13. |
- Andersson, Marcus, et al.
(författare)
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Interfering signals and attenuation : potential problems with communication via the power grid
- 2006
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Ingår i: Proceedings of Nordic Distribution and Asset Management Conference.
-
Konferensbidrag (refereegranskat)abstract
- This paper will give a general overview of the potential problems associated with remote-meter reading via the power grid and describe some of the technologies available. A comparison will be made between the power grid as a communication channel and other, dedicated and shared, channels. Examples will be given of practical cases in which the communication channel does not function in the intended way.
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| 14. |
- Andersson, Martin, et al.
(författare)
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Jobbskapande och produktivitet i små kontra nya företag : Global Award for Entrepreneurship Research 2020 till John Haltiwanger
- 2021
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Ingår i: Ekonomisk Debatt. - : Nationalekonomiska Föreningen. - 0345-2646. ; 7:49, s. 5-15
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Forskningsöversikt (övrigt vetenskapligt/konstnärligt)abstract
- Denna artikel presenterar 2020 års pristagare av Global Award for Entrepreneurship Research – John Haltiwanger – och de bidrag han har gjort inom entreprenörskapsforskningen. Haltiwanger har bl a bidragit till att förbättra vår förståelse av hur jobb skapas och försvinner, kartlägga vilka faktorer som styr produktivitet samt analysera hur småföretag bidrar till den ekonomiska utvecklingen. Hans forskning har inspirerat såväl policydebatt som nationella statistikmyndigheter världen över.
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| 15. |
- Andersson, Roger, et al.
(författare)
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B-field energy dependent phase lag dispersion in magnetomotive ultrasound imaging
- 2015
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Ingår i: 2015 IEEE International Ultrasonics Symposium (IUS). - 1948-5719.
-
Konferensbidrag (refereegranskat)abstract
- Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In experimental phantom studies we have observed a phase lag dispersion in the magnetomotive response in respect to applied time-varying magnetic field (B-field). We hypothesize that this dispersion is triggered by the strength of the applied B-field in combination with concentration of embedded nanoparticles in the region. The cohort response of the nanoparticles aligns as the magnetic field gets more energetic. Moreover, the tightening of the phase response indicate an asymptotic tapering towards a phase limit.
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| 16. |
- Andersson, Rebecca, et al.
(författare)
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Differential role of cytosolic Hsp70s in longevity assurance and protein quality control
- 2021
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- 70 kDa heat shock proteins (Hsp70) are essential chaperones of the protein quality control network; vital for cellular fitness and longevity. The four cytosolic Hsp70's in yeast, Ssa1-4, are thought to be functionally redundant but the absence of Ssa1 and Ssa2 causes a severe reduction in cellular reproduction and accelerates replicative aging. In our efforts to identify which Hsp70 activities are most important for longevity assurance, we systematically investigated the capacity of Ssa4 to carry out the different activities performed by Ssa1/2 by overproducing Ssa4 in cells lacking these Hsp70 chaperones. We found that Ssa4, when overproduced in cells lacking Ssa1/2, rescued growth, mitigated aggregate formation, restored spatial deposition of aggregates into protein inclusions, and promoted protein degradation. In contrast, Ssa4 overproduction in the Hsp70 deficient cells failed to restore the recruitment of the disaggregase Hsp104 to misfolded/aggregated proteins, to fully restore clearance of protein aggregates, and to bring back the formation of the nucleolus-associated aggregation compartment. Exchanging the nucleotide-binding domain of Ssa4 with that of Ssa1 suppressed this 'defect' of Ssa4. Interestingly, Ssa4 overproduction extended the short lifespan of ssa1 Delta ssa2 Delta mutant cells to a lifespan comparable to, or even longer than, wild type cells, demonstrating that Hsp104-dependent aggregate clearance is not a prerequisite for longevity assurance in yeast. Author summary All organisms have proteins that network together to stabilize and protect the cell throughout its lifetime. One of these types of proteins are the Hsp70s (heat shock protein 70). Hsp70 proteins take part in folding other proteins to their functional form, untangling proteins from aggregates, organize aggregates inside the cell and ensure that damaged proteins are destroyed. In this study, we investigated three closely related Hsp70 proteins in yeast; Ssa1, 2 and 4, in an effort to describe the functional difference of Ssa4 compared to Ssa1 and 2 and to answer the question: What types of cellular stress protection are necessary to reach a normal lifespan? We show that Ssa4 can perform many of the same tasks as Ssa1 and 2, but Ssa4 doesn't interact in the same manner as Ssa1 and 2 with other types of proteins. This leads to a delay in removing protein aggregates created after heat stress. Ssa4 also cannot ensure that misfolded proteins aggregate correctly inside the nucleus of the cell. However, this turns out not to be necessary for yeast cells to achieve a full lifespan, which shows us that as long as cells can prevent aggregates from forming in the first place, they can reach a full lifespan.
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| 17. |
- Andersson, Roger, et al.
(författare)
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Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging
- 2016
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Ingår i: 2016 IEEE International Ultrasonics Symposium, IUS 2016. - 9781467398978 ; 2016-November
-
Konferensbidrag (refereegranskat)abstract
- Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event. We hypothesize that this can have bearing in molecular imaging.
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| 18. |
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| 19. |
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| 20. |
- Andersson, Sarah, et al.
(författare)
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Malmbanan Diaries
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This booklet is a report for a case study visit during four day field trip, a group of nine PhD students and their supervisors – all part of the National Research School for Architecture and Planning in the Urban Landscape, APULA – set out to explore what may be considered the outback of Western Europe’s conurbations, the transnational region of Kiruna -Narvik.Both “remote” and “resourceful”, “threatened” and “thriving” (equally relative notions), this region seemed to offer possibilities to reflect upon many of the current tendencies influencing contemporary planning practice and research.
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| 21. |
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| 22. |
- Andersson, Viktor, 1983, et al.
(författare)
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Algae-based biofuel production as part of an industrial cluster
- 2014
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Ingår i: Biomass and Bioenergy. - : Elsevier BV. - 1873-2909 .- 0961-9534. ; 71, s. 113-124
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents a study on the production of biofuels from algae cultivated in municipal wastewater in Gothenburg, Sweden. A possible biorefinery concept is studied based on two cases; Case A) combined biodiesel and biogas production, and Case B) only biogas production. The cases are compared in terms of product outputs and impact on global CO2 emissions mitigation. The area efficiency of the algae-based biofuels is also compared with other biofuel production routes. The study investigates the collaboration between an algae cultivation, biofuel production processes, a wastewater treatment plant and an industrial cluster for the purpose of utilizing material flows and industrial excess heat between the actors. This collaboration provides the opportunity to reduce the CO2 emissions from the process compared to a stand-alone operation. The results show that Case A is advantageous to Case B with respect to all studied factors. It is found that the algae-based biofuel production routes investigated in this study has higher area efficiency than other biofuel production routes. The amount of algae-based biofuel possible to produce corresponds to 31 MWfuel for Case A and 26 MWfuel in Case B.
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| 23. |
- Andersson, Viktor, 1983, et al.
(författare)
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Dubbel energivinst med alger som biobränsle
- 2013
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Ingår i: Energimagasinet.
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Idag kan produktionen av biobränsle påverka livsmedelsförsörjningen negativt. Istället för att biobränsleproduktion ska konkurrera med produktion av livsmedel kan en hittills outnyttjad resurs - kommunalt avloppsvatten - användas för produktion av alger som i sin tur kan användas till biogas och biodiesel. Ny forskning visar på denna potential.
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| 24. |
- Andersson, Veronica, 1979, et al.
(författare)
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Enhancing protein disaggregation restores proteasome activity in aged cells
- 2013
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Ingår i: Aging-Us. - 1945-4589. ; 5:11, s. 802-812
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Tidskriftsartikel (refereegranskat)abstract
- The activity of the ubiquitin-proteasome system, UPS, declines during aging in several multicellular organisms. The reason behind this decline remains elusive. Here, using yeast as a model system, we show that while the level and potential capacity of the 26S proteasome is maintained in replicatively aged cells, the UPS is not functioning properly in vivo. As a consequence cytosolic UPS substrates, such as Delta ssCPY* are stabilized, accumulate, and form inclusions. By integrating a pGPD-HSP104 recombinant gene into the genome, we were able to constitutively elevate protein disaggregase activity, which diminished the accumulation of protein inclusions during aging. Remarkably, this elevated disaggregation restored degradation of a 26S proteasome substrate in aged cells without elevating proteasome levels, demonstrating that age-associated aggregation obstructs UPS function. The data supports the existence of a negative feedback loop that accelerates aging by exacerbating proteostatic decline once misfolded and aggregation-prone proteins reach a critical level.
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| 25. |
- Andersson, Viktor, 1983, et al.
(författare)
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Integrated Algae Cultivation for Municipal Wastewater Treatment and Biofuels Production in Industrial Clusters
- 2012
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Ingår i: World Renewable Energy Forum, WREF 2012. - 9781622760923 ; 1, s. 684-691
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Konferensbidrag (refereegranskat)abstract
- This paper presents a case study on biofuels production from microalgae cultivated in municipal wastewater in Gothenburg, Sweden. A) Combined biodiesel and biogas production and B) only biogas production, are compared in terms of product outputs, impact on global CO2 emissions reduction and economic performance. Land-use efficiency of biofuels from microalgae was compared with other biofuel production routes. The biofuel production process is assumed to be integrated with a wastewater treatment plant and an industrial cluster, providing the opportunity to reduce the CO2 emissions of the process compared to stand-alone operation.The results show that case A is advantageous in terms of all the studied factors. A higher area efficiency of algae biofuels production routes compared to other biofuel production routes was shown. Nutrient availability in municipal wastewater is shown to be the limiting factor regarding product output. The competitive advantage of co-location with a wastewater treatment plant is clearly shown.
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| 26. |
- Ansari, Daniel, et al.
(författare)
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Diagnosis and management of duodenal perforations : a narrative review
- 2019
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 54:8, s. 939-944
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Forskningsöversikt (refereegranskat)abstract
- Duodenal perforation is a rare, but potentially life-threatening injury. Multiple etiologies are associated with duodenal perforations such as peptic ulcer disease, iatrogenic causes and trauma. Computed tomography with intravenous and oral contrast is the most valuable imaging technique to identify duodenal perforation. In some cases, surgical exploration may be necessary for diagnosis. Specific treatment depends upon the nature of the disease process that caused the perforation, the timing, location and extent of the injury and the clinical condition of the patient. Conservative management seems to be feasible in stable patients with sealed perforations. Immediate surgery is required for patients presenting with peritonitis and/or intra-abdominal sepsis. Minimally invasive techniques are safe and effective alternatives to conventional open surgery in selected patients with duodenal perforations. Here we review the current literature on duodenal perforations and discuss the outcomes of different treatment strategies.
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| 27. |
- Arp, Hans Peter H., et al.
(författare)
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The presence, emission and partitioning behavior of polychlorinated biphenyls in waste, leachate and aerosols from Norwegian waste-handling facilities
- 2020
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Ingår i: Science of the Total Environment. - : ELSEVIER. - 0048-9697 .- 1879-1026. ; 715, s. 1-12
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Tidskriftsartikel (refereegranskat)abstract
- Even though production and open use of polychlorinated biphenyls (PCBs) have been phased out in Western industrialised countries since the 1980s, PCBs were still present in waste collected from different waste handling facilities in Norway in 2013. Sums of seven indicator-PCBs (I-PCB7:PCB-28, -52, -101, -118, -138, -153 and -180) were highest in plastic waste (3700 +/- 1800 mu g/kg, n=15), waste electrical and electronic equipment (WEEE) (1300 +/- 400 mu g/kg, n=12) and fine vehicle fluff (1800 = 1400 mu g/kg, n=4) and lowest in glass waste, combustibles, bottom ash and fly ash (0.3 to 65 mu g/kg). Concentrations in leachate water varied from 1.7 to 2900 ng/L, with higher concentrations found at vehicle and WEEE handling facilities. Particles in leachate water exhibited similar PCB sorption properties as solid waste collected on site, with waste-water partitioning coefficients ranging from 10(5)to 10(7) .I-PCB7 in air samples collected at the sites were mostly in the gas phase (100-24000 pg/m(3)), compared to those associated with particles (9-1900 pg/m(3)). In contrast, brominated flame retardants (BFRs) in the same samples were predominantly found associated with particles (e.g. sum of 10 brominated diethyl ethers, Sigma BDE10, associated with particles 77-194,000 pg/m(3)) compared to the gas phase (Sigma DE10 6-473 pg/m(3)). Measured gas-phase I-PCB7 concentrations are less than predicted, assuming waste-air partitioning in equilibrium with predominant waste on site. However, the gas-particle partitioning behavior of PCBs and BFRs could be predicted using an established partitioning model for ambient aerosols. PCB emissions from Norwegian waste handling facilities occurred primarily in the form of atmospheric vapor or leachate particles.
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| 28. |
- Atefyekta, Saba, 1987, et al.
(författare)
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Antibiofilm elastin-like polypeptide coatings: functionality, stability, and selectivity
- 2019
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Ingår i: Acta Biomaterialia. - : Elsevier BV. - 1878-7568 .- 1742-7061. ; 83, s. 245-256
-
Tidskriftsartikel (refereegranskat)abstract
- Antimicrobial peptides (AMPS) are currently receiving interest as an alternative to conventional antibiotics to treat biomaterial-associated infection. However, the inherent instability of such peptides often limits their efficacy in intended clinical applications. Covalent immobilization of AMPs to surfaces is one strategy to increase the long-term stability and minimize the toxicity. In this work, an antimicrobial peptide, RRPRPRPRPWWWW-NH2 (RRP9W4N), was used to modify elastin-like polypeptide (ELP) surface coatings containing cell-adhesive peptide domains (RGD) using covalent chemistry. The AMP retained its antibacterial activity against Staphylococcus epidermidis, Staphylococcus aureus, and Pseudomonas aeruginosa when covalently bonded to ELP surfaces. Simultaneously, the AMP functionalization had insignificant effect on the viability, function, and differentiation of human osteosarcoma MG63 cells and human mesenchymal stem cells (hMSCs). Furthermore, stability of the immobilized AMP in human blood serum was investigated, and the results suggested that the AMP preserved its antibacterial activity up to 24 h. Combined, the results show that covalently attached AMPs onto RGD-containing ELP are an excellent candidate as an antimicrobial coating for medical devices.
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| 29. |
- Balaban, Nathalie Q., et al.
(författare)
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Definitions and guidelines for research on antibiotic persistence
- 2019
-
Ingår i: Nature Reviews Microbiology. - : Nature Publishing Group. - 1740-1526 .- 1740-1534. ; 17:7, s. 441-448
-
Forskningsöversikt (refereegranskat)abstract
- Increasing concerns about the rising rates of antibiotic therapy failure and advances in single-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial persister cells represent a subpopulation of cells that can survive intensive antibiotic treatment without being resistant. Several approaches have emerged to define and measure persistence, and it is now time to agree on the basic definition of persistence and its relation to the other mechanisms by which bacteria survive exposure to bactericidal antibiotic treatments, such as antibiotic resistance, heteroresistance or tolerance. In this Consensus Statement, we provide definitions of persistence phenomena, distinguish between triggered and spontaneous persistence and provide a guide to measuring persistence. Antibiotic persistence is not only an interesting example of non-genetic single-cell heterogeneity, it may also have a role in the failure of antibiotic treatments. Therefore, it is our hope that the guidelines outlined in this article will pave the way for better characterization of antibiotic persistence and for understanding its relevance to clinical outcomes.
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| 30. |
- Berntsson, Shala Ghaderi, et al.
(författare)
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Analysis of DNA repair gene polymorphisms and survival in low-grade and anaplastic gliomas
- 2011
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Ingår i: Journal of Neuro-Oncology. - : Springer Science and Business Media LLC. - 0167-594X .- 1573-7373. ; 105:3, s. 531-538
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to explore the variation in DNA repair genes in adults with WHO grade II and III gliomas and their relationship to patient survival. We analysed a total of 1,458 tagging single-nucleotide polymorphisms (SNPs) that were selected to cover DNA repair genes, in 81 grade II and grade III gliomas samples, collected in Sweden and Denmark. The statistically significant genetic variants from the first dataset (P < 0.05) were taken forward for confirmation in a second dataset of 72 grade II and III gliomas from northern UK. In this dataset, eight gene variants mapping to five different DNA repair genes (ATM, NEIL1, NEIL2, ERCC6 and RPA4) which were associated with survival. Finally, these eight genetic variants were adjusted for treatment, malignancy grade, patient age and gender, leaving one variant, rs4253079, mapped to ERCC6, with a significant association to survival (OR 0.184, 95% CI 0.054-0.63, P = 0.007). We suggest a possible novel association between rs4253079 and survival in this group of patients with low-grade and anaplastic gliomas that needs confirmation in larger datasets.
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| 31. |
- Boen, Rune, et al.
(författare)
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Beyond the global brain differences : intraindividual variability differences in 1q21.1 distal and 15q11.2 bp1-bp2 deletion carriers
- 2024
-
Ingår i: Biological Psychiatry. - 0006-3223 .- 1873-2402. ; 95:2, s. 147-160
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Carriers of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants exhibit regional and global brain differences compared with noncarriers. However, interpreting regional differences is challenging if a global difference drives the regional brain differences. Intraindividual variability measures can be used to test for regional differences beyond global differences in brain structure.Methods: Magnetic resonance imaging data were used to obtain regional brain values for 1q21.1 distal deletion (n = 30) and duplication (n = 27) and 15q11.2 BP1-BP2 deletion (n = 170) and duplication (n = 243) carriers and matched noncarriers (n = 2350). Regional intra-deviation scores, i.e., the standardized difference between an individual's regional difference and global difference, were used to test for regional differences that diverge from the global difference.Results: For the 1q21.1 distal deletion carriers, cortical surface area for regions in the medial visual cortex, posterior cingulate, and temporal pole differed less and regions in the prefrontal and superior temporal cortex differed more than the global difference in cortical surface area. For the 15q11.2 BP1-BP2 deletion carriers, cortical thickness in regions in the medial visual cortex, auditory cortex, and temporal pole differed less and the prefrontal and somatosensory cortex differed more than the global difference in cortical thickness.Conclusions: We find evidence for regional effects beyond differences in global brain measures in 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants. The results provide new insight into brain profiling of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants, with the potential to increase understanding of the mechanisms involved in altered neurodevelopment.
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| 32. |
- Bower, Peter, et al.
(författare)
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Influence of initial severity of depression on effectiveness of low intensity interventions : meta-analysis of individual patient data
- 2013
-
Ingår i: BMJ (Clinical Research Edition). - : BMJ Publishing Group: BMJ. - 0959-8138 .- 1756-1833. ; 346
-
Tidskriftsartikel (refereegranskat)abstract
- Objective To assess how initial severity of depression affects the benefit derived from low intensity interventions for depression.Design Meta-analysis of individual patient data from 16 datasets comparing low intensity interventions with usual care.Setting Primary care and community settings.Participants 2470 patients with depression.Interventions Low intensity interventions for depression (such as guided self help by means of written materials and limited professional support, and internet delivered interventions).Main outcome measures Depression outcomes (measured with the Beck Depression Inventory or Center for Epidemiologic Studies Depression Scale), and the effect of initial depression severity on the effects of low intensity interventions.Results Although patients were referred for low intensity interventions, many had moderate to severe depression at baseline. We found a significant interaction between baseline severity and treatment effect (coefficient −0.1 (95% CI −0.19 to −0.002)), suggesting that patients who are more severely depressed at baseline demonstrate larger treatment effects than those who are less severely depressed. However, the magnitude of the interaction (equivalent to an additional drop of around one point on the Beck Depression Inventory for a one standard deviation increase in initial severity) was small and may not be clinically significant.Conclusions The data suggest that patients with more severe depression at baseline show at least as much clinical benefit from low intensity interventions as less severely depressed patients and could usefully be offered these interventions as part of a stepped care model.
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| 33. |
- Broberg, Sarah, 1983-, et al.
(författare)
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Integrated Algae Cultivation for Biofuels Production in Industrial Clusters
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Declining fossil resources and the issue of climate change caused by anthropogenic emissions of greenhouse gases make global action towards a more sustainable society inevitable. The EU decided in 2007 that 20 % of the union´s energy use should origin from renewable resources by the year 2020. One way of achieving this goal is to increase the utilisation of biofuels. Today 2nd generation biofuels are being developed. They are seen as a more sustainable solution than 1st generation biofuels since they have a higher area efficiency (more fuel produced per area) and the biomass can be cultivated at land which is not suitable for food crops. One of these 2nd generation biofuels are fuels derived from microalgae. In this study a thorough literature survey has been conducted in order to assess the State-of-the-Art in algae biofuels production. The literature review showed the importance of a supplementary function in conjunction with algae cultivation and therefore algae cultivation for municipal wastewater treatment and capturing CO2 emissions from industry was included in the study. It was assumed that all the wastewater of the city of Gothenburg, Sweden, was treated by algae cultivation. A computer model of the whole production process has been developed, covering; algae cultivation in conjunction with wastewater treatment, algae harvesting and biofuels production. Two different cases are modelled; a first case including combined biodiesel and biogas production, and a second case investigating only biogas production. Both cases have been evaluated in terms of product outputs, CO2 emissions savings and compared to each other in an economic sense. Utilising the nutrients in the wastewater of Gothenburg it is possible to cultivate 29 ktalgae/year. In the biogas case it is possible to produce 205 GWhbiogas/year. The biogas/biodiesel case showed a production potential of 63 GWhbiodiesel/year and 182 GWhbiogas/year. There is a deficit of carbon in the wastewater, hence CO2 is injected as flue gases from industrial sources. The biodiesel/biogas case showed an industrial CO2 sequestration capacity of 24 ktCO2/year while in the biogas case 22.6 ktCO2/year, could be captured. Estimating the total CO2 emissions savings showed 46 ktCO2/year in the biodiesel/biogas case and 38 ktCO2/year for the biogas case. The importance of including wastewater treatment in the process was confirmed, as it contributes with 13.7 ktCO2/year to the total CO2 emissions savings. Economic comparison of the two cases showed that biodiesel in conjunction with biogas production is advantageous compared to only biogas production. This is mainly due to the higher overall fuel yield and the high willingness to pay for biodiesel. The total incomes from biodiesel/biogas sales were calculated to 221 million SEK/year and 193 million SEK/year for biogas. It was found that the higher incomes from biodiesel/biogas sales repay the increased investment for the biodiesel process in approximately 3 years.
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| 34. |
- Browall, Sarah, et al.
(författare)
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Clinical manifestations of invasive pneumococcal disease by vaccine and non-vaccine types
- 2014
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Ingår i: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 44:6, s. 1646-1657
-
Tidskriftsartikel (refereegranskat)abstract
- Pneumococcal conjugated vaccines (PCVs) have shown protection against invasive pneumococcal disease by vaccine serotypes, but an increase in non-vaccine serotype disease has been observed. Type-specific effects on clinical manifestation need to be explored.Clinical data from 2096 adults and 192 children with invasive pneumococcal disease were correlated to pneumococcal molecular serotypes. Invasive disease potential for pneumococcal serotypes were calculated using 165 invasive and 550 carriage isolates from children.The invasive disease potential was lower for non-PCV13 compared to vaccine-type strains. Patients infected with non-PCV13 strains had more underlying diseases, were less likely to have pneumonia and, in adults, tended to have a higher mortality. Furthermore, patients infected with pneumococci belonging to clonal serotypes only expressing non-PCV13 capsules had a higher risk for septicaemia and mortality.PCV vaccination will probably lead to a decrease in invasive pneumococcal disease but an alteration in the clinical manifestation of invasive pneumococcal disease. Genetic lineages causing invasive pneumococcal disease in adults often express non-vaccine serotypes, which can expand after vaccination with an increased risk of infection in patients with underlying diseases.
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| 35. |
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| 36. |
- Carlbring, Per, et al.
(författare)
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A randomized controlled trial of Internet-based CBT for perfectionism including an investigation of outcome predictors
- 2017
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Ingår i: Program Book. ; , s. 128-128
-
Konferensbidrag (refereegranskat)abstract
- Being highly attentive to details can be a positive feature. However, for some individuals, perfectionism can lead to distress and is associated with many psychiatric disorders. Cognitive behavior therapy has been shown to yield many benefits for those experiencing problems with perfectionism, but the access to evidence-based care is limited. The current study investigated the efficacy of guided Internet-based Cognitive Behavior Therapy (ICBT) and predictors of treatment outcome. In total, 156 individuals were included and randomized to an eight-week treatment or wait-list control. Self-report measures of perfectionism, depression, anxiety, self-criticism, self-compassion, and quality of life were distributed during screening and at post-treatment. Intention-to-treat were used for all statistical analyses. Moderate to large between-group effect sizes were obtained for the primary outcome measures, Frost Multidimensional Perfectionism Scale, subscales Concerns over Mistakes and Personal Standards, Cohen’s d = 0.68-1.00, 95% Confidence Interval (CI) [0.36-1.33], with 35 (44.9%) of the patients in treatment being improved. Predictors were also explored, but none were related to treatment outcome. In sum, guided ICBT can be helpful for addressing problems with clinical perfectionism, but research of its long-term benefits is warranted.
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| 37. |
- Carneiro, Miguel, et al.
(författare)
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Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
- 2014
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 345:6200, s. 1074-1079
-
Tidskriftsartikel (refereegranskat)abstract
- The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.
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| 38. |
- Castelain, Mickaël, et al.
(författare)
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Fast uncoiling kinetics of F1C pili expressed by uropathogenic Escherichia coli are revealed on a single pilus level using force-measuring optical tweezers
- 2011
-
Ingår i: European Biophysics Journal. - : Springer Science and Business Media LLC. - 0175-7571 .- 1432-1017. ; 40:3, s. 305-316
-
Tidskriftsartikel (refereegranskat)abstract
- Uropathogenic Escherichia coli (UPEC) expressvarious kinds of organelles, so-called pili or fimbriae, thatmediate adhesion to host tissue in the urinary tract throughspecific receptor-adhesin interactions. The biomechanicalproperties of these pili have been considered important forthe ability of bacteria to withstand shear forces from rinsingurine flows. Force-measuring optical tweezers have beenused to characterize individual organelles of F1C typeexpressed by UPEC bacteria with respect to such properties.Qualitatively, the force-versus-elongation response wasfound to be similar to that of other types of helix-like piliexpressed by UPEC, i.e., type 1, P, and S, with force-inducedelongation in three regions, one of which represents theimportant uncoiling mechanism of the helix-like quaternarystructure. Quantitatively, the steady-state uncoiling forcewas assessed as 26.4 ±1.4 pN, which is similar to those ofother pili (which range from 21 pN for SI to 30 pN for type 1).The corner velocity for dynamic response (1,400 nm/s) wasfound to be larger than those of the other pili (400–700 nm/sfor S and P pili, and 6 nm/s for type 1). The kinetics werefound to be faster, with a thermal opening rate of 17 Hz, afew times higher than S and P pili, and three orders ofmagnitude higher than type 1. These data suggest that F1Cpili are, like P and S pili, evolutionarily selected to primarilywithstand the conditions expressed in the upper urinary tract.
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| 39. |
- Chew, Michelle, et al.
(författare)
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National outcomes and characteristics of patients admitted to Swedish intensive care units for COVID-19 A registry-based cohort study
- 2021
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Ingår i: European Journal of Anaesthesiology. - : LIPPINCOTT WILLIAMS & WILKINS. - 0265-0215 .- 1365-2346. ; 38:4, s. 335-343
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Mortality among patients admitted to intensive care units (ICUs) with COVID-19 is unclear due to variable follow-up periods. Few nationwide data are available to compare risk factors, treatment and outcomes of COVID-19 patients after ICU admission. OBJECTIVE To evaluate baseline characteristics, treatments and 30-day outcomes of patients admitted to Swedish ICUs with COVID-19. DESIGN Registry-based cohort study with prospective data collection. SETTING Admissions to Swedish ICUs from 6 March to 6 May 2020 with laboratory confirmed COVID-19 disease. PARTICIPANTS Adult patients admitted to Swedish ICUs. EXPOSURES Baseline characteristics, intensive care treatments and organ failures. MAIN OUTCOMES AND MEASURES The primary outcome was 30-day all-cause mortality. A multivariable model was used to determine the independent association between potential predictor variables and death. RESULTS We identified 1563 patients with complete 30-day follow-up. The 30-day all-cause mortality was 26.7%. Median age was 61 [52 to 69], Simplified Acute Physiology Score III (SAPS III) was 53 [46 to 59] and 62.5% had at least one comorbidity. Median PaO2/FiO(2) on admission was 97.5 [75.0 to 140.6] mmHg, 74.7% suffered from moderate-to-severe acute respiratory failure. Age, male sex [adjusted odds ratio (aOR) 1.5 (1.1 to 2.2)], SAPS III score [aOR 1.3 (1.2 to 1.4)], severe respiratory failure [aOR 3.0 (2.0 to 4.7)], specific COVID-19 pharmacotherapy [aOR 1.4 (1.0 to 1.9)] and continuous renal replacement therapy [aOR 2.1 (1.5 to 3.0)] were associated with increased mortality. Except for chronic lung disease, the presence of comorbidities was not independently associated with mortality. CONCLUSIONS Thirty-day mortality rate in COVID-19 patients admitted to Swedish ICUs is generally lower than previously reported despite a severe degree of hypoxaemia on admission. Mortality was driven by age, baseline disease severity, the presence and degree of organ failure, rather than pre-existing comorbidities.
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| 40. |
- Coad, Alex, et al.
(författare)
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John Haltiwanger : recipient of the 2020 Global Award for Entrepreneurship Research
- 2022
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Ingår i: Small Business Economics. - : Springer. - 0921-898X .- 1573-0913. ; 58:1, s. 15-25
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- The 2020 Global Award for Entrepreneurship Research has been awarded to Professor John Haltiwanger. John Haltiwanger has made significant contributions to the field of entrepreneurship by improving our understanding of job creation and destruction, productivity growth, and the role of small- and medium-sized firms (SMEs) in economic development. He has played a major role in the careful development of large, longitudinal firm-level datasets, and introduced a novel and widely adopted measure of firm growth that addresses previous statistical biases. His work has influenced public policy and national statistical offices around the world. Plain English Summary The winner of the 2020 Global Award for Entrepreneurship Research, John Haltiwanger, has pioneered research showing that it is mainly firm age, not size, that matters for job creation. Through analyzing the relationship between employment, growth, and firms, he has advanced our understanding of how the economy works. He has done this by building new datasets and introducing a new measure of firm growth, solving problems encountered with earlier techniques. His work has also broadened the policy debate on entrepreneurship and inspired people all around the world. From a policy perspective, John Haltiwanger has shown that it is difficult to justify targeted industrial and commercial policies, and if job creation is to be supported, politicians need to target young firms rather than small firms. These important findings from John Haltiwanger's pioneering work have been published in world-class leading academic and scientific journals.
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| 41. |
- Conrad, Sarah, et al.
(författare)
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Distribution of Fe isotopes in particles and colloids in the salinity gradient along the Lena River plume, Laptev Sea
- 2019
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Ingår i: Biogeosciences. - : European Geosciences Union (EGU). - 1726-4170 .- 1726-4189. ; 16:6, s. 1305-1319
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Tidskriftsartikel (refereegranskat)abstract
- Riverine Fe input is the primary Fe source for the ocean. This study is focused on the distribution of Fe along the Lena River freshwater plume in the Laptev Sea using samples from a 600 km long transect in front of the Lena River mouth. Separation of the particulate ( > 0.22 μm), colloidal (0.22 μm–1 kDa), and truly dissolved (< 1 kDa) fractions of Fe was carried out. The total Fe concentrations ranged from 0.2 to 57μM with Fe dominantly as particulate Fe. The loss of > 99% of particulate Fe and about 90% of the colloidal Fe was observed across the shelf, while the truly dissolved phase was almost constant across the Laptev Sea. Thus, the truly dissolved Fe could be an important source of bioavailable Fe for plankton in the central Arctic Ocean, together with the colloidal Fe. Fe-isotope analysis showed that the particulate phase and the sediment below the Lena River freshwater plume had negative δ56Fe values (relative to IRMM-14). The colloidal Fe phase showed negative δ56Fe values close to the river mouth (about -0.20 ‰) and positive δ56Fe values in the outermost stations (about +0.10 ‰). We suggest that the shelf zone acts as a sink for Fe particles and colloids with negative δ56Fe values, representing chemically reactive ferrihydrites. The positive δ56Fe values of the colloidal phase within the outer Lena River freshwater plume might represent Fe oxyhydroxides, which remain in the water column, and will be the predominant δ56Fe composition in the Arctic Ocean.
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| 42. |
- Cooke, Neil, et al.
(författare)
-
Euniwell : Maximising academic and social outcomes in engineering education
- 2023
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Ingår i: European Society for Engineering Education (SEFI). - : European Society For Engineering Education (SEFI). - 9782873520267 ; , s. 1857-1865
-
Konferensbidrag (refereegranskat)abstract
- The ERASMUS+ European University for Well-Being (EUniWell) alliance’s mission aims to resolve the paradox of Europeans’ relative prosperity against the global security and sustainability challenge. “Maximising Academic and Social Outcomes in Engineering Education” is a project which interprets this contradiction for engineering educators; how to best teach non-technical skills to ensure engineers make the utmost contribution to societal wellbeing? Appreciably, the social outcome for the person who becomes an engineer is positive because the profession is relatively well-paid. Therefore, engineering education is good for social mobility providing the learning environment narrows attainment gaps between disadvantaged and mainstream cohorts. Accordingly, our strategy is to bring together the expertise of the British, French, Italian and Swedish faculties to transfer best practice for professional, business and sustainability skill teaching, while contrasting how their disadvantaged cohorts present. The project has two primary objectives: To understand how partners differ in terms of skill teaching, and how students from disadvantaged backgrounds are accommodated. The paper describes the background and rationale of the project, and its research design and methodology. Although the project is still in progress and data collection is still underway, this paper provides insights and perspectives for engineering educators looking to design similar collaborations to share best practice, while considering engineering identities and their underlying competencies.
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| 43. |
- Cooke, Niel, et al.
(författare)
-
Maximising Academic and Social Outcomes
- 2023
-
Ingår i: Proceedings of the 19th International CDIO Conference, Trondheim, Norway, 26-29 June 2023. - Trondheim : NTNU SEED. - 9788230361863 ; , s. 644-655
-
Konferensbidrag (refereegranskat)abstract
- The MASOEE project brings together engineering faculties in the EUniWell alliance to share best practices for teaching transversal skills so that engineers contribute to societal well-being. The study combines the expertise of several engineering faculties at European universities. It focuses on sharing and developing expertise to improve the social outcomes of engineering students. Namely, researchers examine the similarities and differences between partners regarding their student bodies, teaching, programme structures, and institutions’ culture. Moreover, the work also explores how transversal skills are taught, what student attitudes are in terms of learning these skills, and how educators can better teach them. The research design includes several activities across four work packages (WPs). To ensure that partners use the same skill descriptions, we use well-established organizations' existing definitions. WP1 strives to identify best practices within EUniWell based on the 15 entrepreneurial competencies defined in EU EntreComp Framework. WP2 targets engineering students' ability to solve complex challenges, communication, and networking skills defined in the "21st century skills" by the World Economic Forum. WP3 investigates the engineering schools’ capacity to train engineering students in sustainable competence, forming responsible engineers capable of developing sustainable solutions using the skills defined by the EU GreenComp. WP4 supports the other packages with engineering education research, specifically data collection and analysis, knowledge forming, and evaluation. The project runs from August 2022 until September 2023. The MASOEE project partners gather knowledge within their organisations through joint surveys and focus groups and collectively identify and share best practices. The engineering identity, taught as transversal skills by participating partners, can evolve from a traditional technologist identity along three paths: the self-made engineer, the progressive technologist, and the responsible engineer. By sharing best practices for teaching these skills, we believe we will better understand what the future engineer - who integrates all three identities – will be.
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| 44. |
- Cooke, Neil, et al.
(författare)
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Supporting Students From Different Universities And Backgrounds To Improve Their Academic And Social Outcomes : Euniwell MASOEE Project Workshop
- 2023
-
Ingår i: European Society for Engineering Education (SEFI). - : European Society For Engineering Education (SEFI). - 9782873520267 ; , s. 3125-3130
-
Konferensbidrag (refereegranskat)abstract
- There is a notable discrepancy between the relative prosperity of Europeans and the global security and sustainability challenge. The mission of the ERASMUS+ 2020 European University for Well-Being (EUniWell) alliance is to address this. Our project, “Maximizing Academic and Social Outcomes in Engineering Education” (MASOEE) interprets this contradiction for engineering educators, exploring how to ensure graduates make the utmost contribution to societal wellbeing by narrowing attainment gaps. We are combining the expertise of British, French, Italian, and Swedish faculties to identify, share, and ultimately transfer best practices for professional, business, and sustainability skill teaching that is aligned to the EU competency frameworks including EntreComp (Bacigalupo et al. 2016) and GreenComp (Bianchi, Pisiotis, and Cabrera Giraldez 2022). Furthermore, we are finding out how disadvantaged cohorts in each partner faculty are characterized and supported. The project is guided by the following research questions:What are the similarities and differences between our students, staff, teaching, and culture?How are skills taught and embedded in programmes? What are student attitudes to learning these? How do we currently define and measure social outcomes?Which new approaches can we employ improve social and academic outcomes?
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| 45. |
- Darmadi, Iwan, 1990, et al.
(författare)
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Bulk-Processed Pd Nanocube-Poly(methyl methacrylate) Nanocomposites as Plasmonic Plastics for Hydrogen Sensing
- 2020
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Ingår i: ACS Applied Nano Materials. - : American Chemical Society (ACS). - 2574-0970. ; 3:8, s. 8438-8445
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Tidskriftsartikel (refereegranskat)abstract
- Nanoplasmonic hydrogen sensors are predicted to play a key role in safety systems of the emerging hydrogen economy. Pd nanoparticles are the active material of choice for sensor prototype development due to their ability to form a hydride at ambient conditions, which creates the optical contrast. Here, we introduce plasmonic hydrogen sensors made from a thermoplastic nanocomposite material, that is, a bulk material that can be molded with standard plastic processing techniques, such as extrusion and three-dimensional (3D) printing, while at the same time being functionalized at the nanoscale. Specifically, our plasmonic plastic is composed of hydrogensensitive and plasmonically active Pd nanocubes mixed with a poly(methyl methacrylate) matrix, and we optimize it by characterization from the atomic to the macroscopic level. We demonstrate meltprocessed deactivation-resistant plasmonic hydrogen sensors, which retain full functionality even after SO weeks. From a wider perspective, we advertise plasmonic plastic nanocomposite materials for application in a multitude of active plasmonic technologies since they provide efficient scalable processing and almost endless functional material design opportunities via tailored polymer- colloidal nanocrystal combinations.
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| 46. |
- Dawody, Hevi, 1990-
(författare)
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Terrorism and Exclusion from Refugee Protection
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this study is to provide further contributions to the field of international refugee law and exclusion from refugee protection, particularly concerning exclusion cases involving terrorism. The study establishes a framework relevant for interpreting Article 1F of the 1951 Refugee Convention (also known as the exclusion provision) in accordance with international norms. The goal is to enable a clear and consistent approach to understanding the exclusion provision, especially in cases related to terrorism. The study delves into the evidentiary standard required for exclusion under Article 1F, discussing both the meaning of the standard ‘serious reasons for considering’ and its threshold. This examination aids an understanding of when exclusion from refugee protection is triggered, focusing in particular on cases involving membership of a terrorist organisation. One of the central conclusions highlighted in this study is that the exclusion provision is contained within an international treaty and therefore should be interpreted and applied in accordance with international law standards. Here, the language of international human rights law and international criminal law should mainly be used, with an emphasis on interpreting the objectives of the 1951 Refugee Convention in good faith for the purpose of avoiding vague and arbitrary interpretation of the exclusion provision. In this regard, this dissertation underscores a position that argues against the notion that mere membership in a terrorist organisation should automatically warrant exclusion from refugee protection. Lastly, the study suggests that achieving a coherent and consistent interpretation of the exclusion provision is essential for promoting legal certainty in exclusion cases, as much as for enhancing predictability and fairness in the decision-making process.
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| 47. |
- Ddiba, Daniel, 1990-, et al.
(författare)
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A review of how decision support tools address resource recovery in sanitation systems
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Globally, there is increasing interest in recovering resources from sanitation systems. However, the process of planning and implementing circular sanitation is complex and can necessitate software-based tools to support decision-making. In this paper, we review 24 decision support software tools used for sanitation planning, to generate insights into how they address resource recovery across the sanitation chain. The findings reveal that several tools can address many planning issues around resource recovery in sanitation including analysis of material flows, estimating resource recovery potential and assessing the sustainability, demand and acceptability of resource recovery technologies and products, at various planning stages. The results presented here can guide users in the choice of different tools depending on, for example, what kind of impacts the user is interested in, the stage of the planning process and the sanitation service that are in focus. However, some issues are not adequately covered by the tools including the assessment of the overall level of resource circularity in a sanitation system, the selection of resource recovery products with significant demand in a way that matches the available supply of waste streams in an area and determining the sustainability implications of the use phase of resource recovery products. While there is scope to develop new tools or to modify existing ones to cover these gaps, communication efforts are needed to create awareness about existing tools and how they address resource recovery. It is also important to further integrate the available tools into urban planning processes to move them beyond research and pilots into practice, and hopefully contribute towards more circular sanitation systems.
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| 48. |
- Ddiba, Daniel Isaac Waya, 1990-, et al.
(författare)
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A review of how decision support tools address resource recovery in sanitation systems
- 2023
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Ingår i: Journal of Environmental Management. - : Elsevier BV. - 0301-4797 .- 1095-8630. ; 342
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Forskningsöversikt (refereegranskat)abstract
- Globally, there is increasing interest in recovering resources from sanitation systems. However, the process of planning and implementing circular sanitation is complex and can necessitate software-based tools to support decision-making. In this paper, we review 24 decision support software tools used for sanitation planning, to generate insights into how they address resource recovery across the sanitation chain. The findings reveal that the tools can address many planning issues around resource recovery in sanitation including analysis of material flows, integrating resource recovery technologies and products in the design of sanitation systems, and assessing the sustainability implications of resource recovery. The results and recommendations presented here can guide users in the choice of different tools depending on, for example, what kind of tool features and functions the user is interested in as well as the elements of the planning process and the sanitation service chain that are in focus. However, some issues are not adequately covered and need improvements in the available tools including quantifying the demand for and value of resource recovery products, addressing retrofitting of existing sanitation infrastructure for resource recovery and assessing social impacts of resource recovery from a life cycle perspective. While there is scope to develop new tools or to modify existing ones to cover these gaps, communication efforts are needed to create awareness about existing tools, their functions and how they address resource recovery. It is also important to further integrate the available tools into infrastructure planning and programming processes by e.g. customizing to relevant planning regimes and procedures, to move them beyond research and pilots into practice, and hopefully contribute towards more circular sanitation systems.
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| 49. |
- Ddiba, Daniel Isaac Waya, 1990-, et al.
(författare)
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Governing the circular economy : Assessing the capacity to implement resource-oriented sanitation and waste management systems in low- and middle-income countries
- 2020
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Ingår i: Earth System Governance. - : Elsevier BV. - 2589-8116. ; 4, s. 100063-
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Tidskriftsartikel (refereegranskat)abstract
- Transitioning to a circular economy requires strategic investments in infrastructure, but it also requires policy coherence, coordination and collaboration among stakeholders across sectors and governance levels. In this paper, we aimed to identify the factors that facilitate or impede governance capacity to adopt circularity in the form of resource recovery from urban organic waste streams. We conducted a literature review and semi-structured interviews using the ‘Governance Capacity Framework’ in a case study of Naivasha, Kenya. Our findings emphasize the importance of leadership from the public sector in co-developing visionary strategies for circularity and using their convening power to facilitate cross-sectoral collaboration. Moreover, we identify a need for bridging theoretical circular economy concepts to initiatives in local communities of practice. The insights in this paper are relevant for advancing the understanding of challenges for governance of the circular economy especially in low-and middle-income country contexts.
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| 50. |
- Ddiba, Daniel Isaac Waya, 1990-, et al.
(författare)
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The circular economy potential of urban organic waste streams in low- and middle-income countries
- 2021
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Ingår i: Environment, Development and Sustainability. - : Springer Nature. - 1387-585X .- 1573-2975.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- There is growing recognition of the potential environmental and socio-economic benefits of applying a circular economy approach to urban organic waste management through resource recovery. Decisions around planning and implementing circular urban waste systems require estimates of the quantity of resources available in waste streams and their potential market value. However, most case-studies have so-far been conducted in high-income countries and cities in low- and middle-income countries have different challenges when developing a circular economy. The present paper explores these issues by estimating the potential for resource recovery from organic waste streams in the context of low- and middle-income countries, illustrated in Kampala, Uganda. A simplified material flow analysis approach is used to track the transformation of waste streams, namely; faecal sludge, sewage sludge and organic solid waste into the resource recovery products biogas, solid fuel, black soldier fly larvae and compost. Findings indicate that even at current rates of waste collection, the three waste streams combined could annually yield 135,000 tonnes of solid fuel or 39.6 million Nm3 of biogas or 15,000 tonnes of black soldier fly larvae or 108,000 tonnes of compost. Potential revenues from the products could range from 5.1 million USD for compost to 47 million USD for biogas, annually. This case study demonstrates how complex information describing urban waste in specific cities can be presented to facilitate decision-making and planning by stakeholders. By highlighting different resource recovery opportunities, application of this approach could provide an incentive for more sustainable urban sanitation and waste management systems.
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