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3.
  • Ahnesjö, Magnus, et al. (författare)
  • Tomographic reconstructions and predictions of radial void distribution in BWR fuel bundle with part-length rods
  • 2015
  • Konferensbidrag (refereegranskat)abstract
    • The Westinghouse FRIGG facility, in Västerås/Sweden, is dedicated to the measurement of critical power,stability and pressure drop in fuel rod bundles under BWR operating conditions (steady-state andtransient). Capability to measure cross-sectional void and radial void distributions during steady-stateoperation was already considered when the facility was built in the late 1960s, using gamma transmissionmeasurements. In the 1990s, redesigned equipment was installed to allow for full 2D tomography andsome test campaigns were successfully run where the void was measured in the Westinghouse SVEA-96fuel bundle geometry with and without part-length rods.In this paper, the tomographic raw data from the SVEA-96 void measurement campaigns are revisitedusing various tomographic reconstruction techniques. This includes an algebraic method and a filteredback-projection method. Challenges, for example due to artifacts created by high difference in gammaabsorption, or to accurately identify the location of the bundle structure, are resolved. The resultingdetailed void distributions are then averaged over entire sub-channels or within the steam core only, forcomparison against sub-channel simulations.The resulting void distributions are compared against sub-channel void predictions using the VIPREW/MEFISTO code. The region downstream the part-length rods are of particular interest to investigatehow the void in the steam core is redistributed within the open region of the bundle. The comparisonshows a reasonable agreement between the measurements and the predictions.
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4.
  • Andersson, T., et al. (författare)
  • Selective adsorption, bound states, and potential parameters for He, Ne, and Ar interacting with a Cu(110) surface
  • 2006
  • Ingår i: J. Chem. Phys.. - : AIP Publishing. - 0021-9606. ; 124
  • Tidskriftsartikel (refereegranskat)abstract
    • Using nozzle beams of He, Ne, and Ar, we have measured diffractive selective adsorption resonances from a Cu(110) surface kept at 20 K. Bound state energies of the atom-surface potentials have been determined from plots of the measured resonance energies versus incident angle and their fits to calculated kinematical dispersion relations. For 3He and 4He we have found a unique level assignment that is compatible with a single gas-surface potential curve with a well depth of 6.05 meV of the He–Cu(110) potential. This value is about 10% larger than the prediction of 5.55 meV from the current physisorption theory. The Ne and Ar data reveal a large number of closely spaced levels with level separations and estimated van der Waals coefficients that are compatible with available theoretical data.
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5.
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6.
  • Lyxell, Björn, et al. (författare)
  • Phonological representation and speech understanding with cochlear implants in deafened adults
  • 1998
  • Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 39:3, s. 175-179
  • Tidskriftsartikel (refereegranskat)abstract
    • In the present study cognitive performance in 15 deafened adult cochlear implant candidates was examined and related to level of speech understanding after 12 months of experience with the implant. The implant group performed on par with normal hearing controls in all cognitive tasks used in the study with one exception: Performance was significantly lower in cognitive tasks where use of a phonological representation of sound is a key task-demand. Observations of the implanted individuals' level of speech understanding indicate that only those individuals who, pre-operatively, were in possession of phonological representations comparable to that of normal hearing could follow and understand a speaker that was out of sight. The results are discussed with respect to (a) deterioration in the phonological representation of sounds as a function of absence of external auditory stimulation, and (b) the role of cognitive factors in predicting success in speech understanding with the implant.
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7.
  • Olin, Anna-Carin, 1960, et al. (författare)
  • Prevalence of asthma and exhaled nitric oxide are increased in bleachery workers exposed to ozone.
  • 2004
  • Ingår i: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. - 0903-1936. ; 23:1, s. 87-92
  • Tidskriftsartikel (refereegranskat)abstract
    • The aims of the present study were to determine whether exposure to high peaks of ozone resulted in an increased prevalence of asthma or respiratory symptoms among bleachery workers and whether nitric oxide (NO) was elevated in the exhaled air of these workers. Bleachery workers (n=228) from three Swedish pulp mills who had been exposed to ozone, together with 63 unexposed control subjects, were investigated by means of spirometry, Phadiatop, exhaled and nasal NO and answers to a questionnaire concerning respiratory symptoms and exposure. Exposure to an ozone peak that gave rise to respiratory symptoms was defined as a "gassing". Bleachery workers reporting four or more gassings involving ozone had an increased prevalence of adult-onset asthma, wheeze, and current asthma symptoms. They also had a higher median concentration of exhaled NO in comparison with those who reported no such gassings (19.2 versus 15.7 parts per billion). No such associations were found in respect of nasal NO. The results from this study show that bleachery workers who have been repeatedly exposed to ozone gassings have an increased prevalence of adult-onset asthma. The results also indicate exhaled nitric oxide may be a marker of airway inflammation in bleachery workers who have been exposed to high peaks of ozone.
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8.
  • Ali, Alaa M. G., et al. (författare)
  • Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases
  • 2014
  • Ingår i: Cancer Epidemiology Biomarkers & Prevention. - 1538-7755 .- 1055-9965. ; 23:6, s. 934-945
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre-or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer. (C) 2014 AACR.
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9.
  • Andersson, Adam, 1979, et al. (författare)
  • Duality in refined Sobolev–Malliavin spaces and weak approximation of SPDE
  • 2016
  • Ingår i: Stochastic Partial Differential Equations: Analysis and Computations. - : Springer Science and Business Media LLC. - 2194-0401 .- 2194-041X. ; 4:1, s. 113-149
  • Tidskriftsartikel (refereegranskat)abstract
    • We introduce a new family of refined Sobolev–Malliavin spaces that capture the integrability in time of the Malliavin derivative. We consider duality in these spaces and derive a Burkholder type inequality in a dual norm. The theory we develop allows us to prove weak convergence with essentially optimal rate for numerical approximations in space and time of semilinear parabolic stochastic evolution equations driven by Gaussian additive noise. In particular, we combine a standard Galerkin finite element method with backward Euler timestepping. The method of proof does not rely on the use of the Kolmogorov equation or the Itō formula and is therefore non-Markovian in nature. Test functions satisfying polynomial growth and mild smoothness assumptions are allowed, meaning in particular that we prove convergence of arbitrary moments with essentially optimal rate.
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10.
  • Andersson, Adam, 1979, et al. (författare)
  • Duality in refined Watanabe-Sobolev spaces and weak approximations of SPDE
  • 2013
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • In this paper we introduce a new family of refined Watanabe- Sobolev spaces that capture in a fine way integrability in time of the Malliavin derivative. We consider duality in these spaces and derive a Burkholder type inequality in a dual norm. The theory we develop allows us to prove weak convergence with essentially optimal rate for numerical approximations in space and time of semilinear parabolic stochastic evolution equations driven by Gaussian additive noise. In particular, we combine Galerkin finite element methods with a backward Euler scheme in time. The method of proof does not rely on the use of the Kolmogorov equation or the It¯o formula and is therefore in nature non-Markovian. With this method polynomial growth test functions with mild smoothness assumptions are allowed, meaning in particular that we prove convergence of arbitrary moments with essentially optimal rate. Our Gronwall argument also yields weak error estimates which are uniform in time without any additional effort.
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11.
  • Andersson, Adam, 1979, et al. (författare)
  • Weak convergence for a spatial approximation of the nonlinear stochastic heat equation
  • 2012
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • We find the weak rate of convergence of approximate solutions of the nonlinear stochastic heat equation, when discretized in space by a standard finite element method. Both multiplicative and additive noise is considered under different assumptions. This extends an earlier result of Debussche in which time discretization is considered for the stochastic heat equation perturbed by white noise. It is known that this equation only has a solution in one space dimension. In order to get results for higher dimensions, colored noise is considered here, besides the white noise case where considerably weaker assumptions on the noise term is needed. Integration by parts in the Malliavin sense is used in the proof. The rate of weak convergence is, as expected, essentially twice the rate of strong convergence.
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12.
  • Andersson, Adam, 1979, et al. (författare)
  • Weak convergence for a spatial approximation of the nonlinear stochastic heat equation
  • 2016
  • Ingår i: Mathematics of Computation. - : American Mathematical Society (AMS). - 0025-5718 .- 1088-6842. ; 85, s. 1335-1358
  • Tidskriftsartikel (refereegranskat)abstract
    • We find the weak rate of convergence of the spatially semidiscrete finite element approximation of the nonlinear stochastic heat equation. Both multiplicative and additive noise is considered under different assumptions. This extends an earlier result of Debussche in which time discretization is considered for the stochastic heat equation perturbed by white noise. It is known that this equation has a solution only in one space dimension. In order to obtain results for higher dimensions, colored noise is considered here, besides white noise in one dimension. Integration by parts in the Malliavin sense is used in the proof. The rate of weak convergence is, as expected, essentially twice the rate of strong convergence.
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13.
  • Andersson, Adam, 1979, et al. (författare)
  • Weak error analysis for semilinear stochastic Volterra equations with additive noise
  • 2014
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • We prove a weak error estimate for the approximation in space and time of a semilinear stochastic Volterra integro-differential equation driven by additive space-time Gaussian noise. We treat this equation in an abstract framework, in which parabolic stochastic partial differential equations are also included as a special case. The approximation in space is performed by a standard finite element method and in time by an implicit Euler method combined with a convolution quadrature. The weak rate of convergence is proved to be twice the strong rate, as expected. Our weak convergence result concerns not only the solution at a fixed time but also integrals of the entire path with respect to any finite Borel measure. The proof does not rely on a Kolmogorov equation. Instead it is based on a duality argument from Malliavin calculus.
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14.
  • Andersson, Adam, 1979, et al. (författare)
  • Weak error analysis for semilinear stochastic Volterra equations with additive noise
  • 2016
  • Ingår i: Journal of Mathematical Analysis and Applications. - : Elsevier BV. - 0022-247X .- 1096-0813. ; 437:2, s. 1283-1304
  • Tidskriftsartikel (refereegranskat)abstract
    • We prove a weak error estimate for the approximation in space and time of a semilinear stochastic Volterra integro-differential equation driven by additive space-time Gaussian noise. We treat this equation in an abstract framework, in which parabolic stochastic partial differential equations are also included as a special case. The approximation in space is performed by a standard finite element method and in time by an implicit Euler method combined with a convolution quadrature. The weak rate of convergence is proved to be twice the strong rate, as expected. Our convergence result concerns not only functionals of the solution at a fixed time but also more complicated functionals of the entire path and includes convergence of covariances and higher order statistics. The proof does not rely on a Kolmogorov equation. Instead it is based on a duality argument from Malliavin calculus.
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15.
  • Andersson, Eva, 1955, et al. (författare)
  • A case-referent study of cancer mortality among sulfate mill workers in Sweden.
  • 2001
  • Ingår i: Occupational and environmental medicine. - 1351-0711. ; 58:5, s. 321-4
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: To investigate whether workers in Swedish sulfate mills have an increased risk of death from certain malignancies that have previously been linked to the pulping process. METHODS: Subjects of the study (n=2480) were men aged 40-75 at death during 1960-89 in the parishes surrounding four sulfate mills. Exposure assessment was based on information from the personnel files in the mills- 35% of the subjects were recognised there, and work categories were created. RESULTS: Among all sulfate mill workers, the odds ratio (OR) (90% confidence interval (90% CI)) for death from lung cancer was 1.6 (1.1 to 2.3), pleural mesotheliomas 9.5 (1.9 to 48), brain tumours 2.6 (1.2 to 5.3), and liver or biliary tract cancer 2.3 (1.0 to 5.2). There was an increased mortality from leukaemia among workers in the soda recovery plant (5.9 (2.6 to 13)) and bleaching plant and digester house (2.8 (1.0 to 7.5)). CONCLUSIONS: Sulfate mill workers were at increased risk of dying from lung cancer and pleural mesotheliomas, probably due to exposure to asbestos. Increased risks of brain tumours and cancers of the liver or biliary tract were also found but the aetiology is not obvious.
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16.
  • Andersson, Eva, 1955, et al. (författare)
  • Adult-onset asthma and wheeze among irritant-exposed bleachery workers.
  • 2003
  • Ingår i: American journal of industrial medicine. - : Wiley. - 0271-3586. ; 43:5, s. 532-538
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Whether new-onset asthma is associated with irritant exposure is unclear. The aim was to investigate if occupational exposure to irritant gases, especially repeated peak exposure (gassings), increased the risk of obstructive airways disease. Methods Data on airway symptoms and exposure among bleachery (n=101) and paper department workers (n=314) were collected by a questionnaire. Incidence rates and hazard ratios (HR) (Cox regression) were calculated. Non-responders were interviewed by telephone. Results The incidence rate for adult-onset physician-diagnosed asthma among bleachery workers reporting gassings giving rise to respiratory symptoms was 7.6/103 person-years and for those without gassings 2.2/103 person-years, compared to 1.0/103 person-years for paper workers. In a Cox regression model for asthma (n=12), stratified for sex, HR for gassings were 5.6 (95% confidence intervals (CI) 1.6–20), for hay fever 3.0 (95% CI 0.8–11), and for ever smoking 0.7 (95% CI 0.2–2.4). The same model for adult-onset wheeze gave HR of 5.2 (95% CI 2.2–12), 1.7 (95% CI 0.6–5.4), and 1.1 (95% CI 0.5–2.7), respectively. Conclusions Repeated peak exposure to irritant gases, here studied as gassings in the pulp industry, increased the risk for both adult-onset asthma and wheeze.
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17.
  • Andersson, Eva, 1943-, et al. (författare)
  • Audiometric screening of a population with intellectual disability
  • 2013
  • Ingår i: International Journal of Audiology. - London : Informa Healthcare. - 1499-2027 .- 1708-8186. ; 52:1, s. 50-56
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: Evaluation of pure-tone audiometry (PTA) in hearing screening of a population with mild to profound intellectual disability (ID).Design: PTA was performed at six frequencies at the screening level 20 dB HL. Referral criteria were threshold levels ≥ 25 dB HL at two or more frequencies for one ear or both.Study sample: 1478 participants aged 7–91 years were included.Results: 1470 (99.5%) people cooperated in screening of which 1325 (90%) could be tested on both ears at all six frequencies. A majority, 987 (66.8%), performed ordinary PTA, 234 (15.8%) conditioned play audiometry, and 249 (16.9%) behavioural observation audiometry. Six hundred and sixty-nine (45%) passed and 809 (55%) failed according to referral criteria. Of those failing, 441 (54.5%) accepted referral to clinical evaluation.Conclusions: PTA with slight modifications is applicable for screening of a population with mild to profound intellectual disability. The most challenging and time-consuming activity is to introduce the test procedure in a way that reduces anxiety and establishes trust.
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18.
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19.
  • Andersson, Eva, et al. (författare)
  • Evaluation of OAE-recording as a complementary test method for adults with moderate to profound mental retardation
  • 2000
  • Ingår i: Scandinavian Audiology. - : Taylor & Francis. - 0105-0397 .- 1940-2872. ; 29:2, s. 120-126
  • Tidskriftsartikel (refereegranskat)abstract
    • The recording of otoacoustic emissions (OAE) was evaluated as a complementary test method for adults with moderate to profound mental retardation (MR). A portable apparatus, ILO 288 Echoport linked to a Compaq LTE 5100 notebook with software ILO 88 V 4.2, was used. Otoscopy and tympanometry were also performed. Criteria for emissions were S/N 3 dB or more and reproducibility 60% or more for at least three frequency-bands. The criteria for partial emissions were the same, but for only one or two frequencies. Two examiners were needed: one to keep the tested person calm and quiet and the other to handle the keyboard. Thirty-eight people with different degrees of MR in connection with other disabilities were included. They had all exhibited incomplete results in a previous hearing screening of more than 1000 adults with MR. Reproducible transiently evoked OAEs (TEOAE) were recorded from II ears (7 people), partial TEOAEs from 6 ears (4 people) and no emissions from 15 ears (10 people). Registration from 24 ears (13 people) could not be evaluated because of too much external and internal noise. Eight people rejected the examination. Only four people showed emissions in both ears. Accordingly, 34 people (89.5%) had to be re-tested or referred for further investigation, 21 of them (55%) because of noisy recordings or no co-operation. It is concluded that the TEOAE-test in its present form cannot fulfil the demands for a functioning test method for this population. In single cases, however, TEOAE-recording can complement other audiological tests.
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20.
  • Andersson, Eva, 1955, et al. (författare)
  • Incidence of asthma among workers exposed to sulfur dioxide and other irritant gases
  • 2006
  • Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 27:4, s. 720-5.
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of the present study was to investigate whether repeated peak exposure (gassings) to sulphur dioxide (SO2) and other irritant gases increases the risk of new-onset asthma. A questionnaire was sent to 4,112 sulphite workers, of whom 1,919 completed the questionnaire and 396 completed the short-form questionnaire, which was sent out as a last reminder. A sample of 130 nonrespondents completed a telephone interview using the short-form questionnaire. The incidence of adult-onset, physician-diagnosed asthma during employment duration was analysed in relation to exposure to SO2 and gassings giving rise to respiratory symptoms. Incidence rates, as well as incidence rate ratios with 95% confidence interval (CI), were calculated. Further Cox regression models were used allowing assessment of hazard ratios (HR) stratified for sex and adjusted for atopy, smoking habits and age. The incidence rate for asthma among sulphite mill workers reporting gassings of SO2 was 6.2 out of 1,000 person-yrs, compared with 1.9 out of 1,000 person-yrs among subjects unexposed to SO2 and any gassings (HR (95% CI) 4.0 (2.1-7.7)). Among males reporting gassings to SO2, the HR (95% CI) for asthma was 5.8 (2.6-13) compared with unexposed males. In conclusion, repeated peak exposure to sulphur dioxide increased the incidence of asthma during work in sulphite pulp mills, which supports the hypothesis of irritant-induced asthma.
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22.
  • Andersson, Erika, et al. (författare)
  • Variational properties of a pumped dynamical system
  • 2010
  • Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 81:2, s. 022111-
  • Tidskriftsartikel (refereegranskat)abstract
    • We earlier constructed a generalized entropy concept to show the direction of time in an evolution following from a Markov generator. In such a dynamical system the entity found changes in a monotonic way starting from any initial state of the system. In this article, we generalize the treatment to the case when population is pumped into the system from levels not explicitly considered. These populations then pass through the coupled levels and exit by decay to levels outside the system. We derive the form of the equation of motion and relate it to our earlier treatments. It turns out that the formalism can be generalized to the new situation. Its physically relevant features are demonstrated and the behavior obtained is illustrated by a numerical treatment of the standard two-level system with pumping and relaxation included.
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23.
  • Andersson, Göran, 1957, et al. (författare)
  • Golv - De nordsvenska timmerhusens konstruktion
  • 2008
  • Bok (övrigt vetenskapligt/konstnärligt)abstract
    • Beskrivningar av golv i timmerhus, analys av funktionskrav och förslag till konstruktiv indelning. Rikligt med förklarande ritningar.
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24.
  • Andersson, Göran, 1957, et al. (författare)
  • Tak - De nordsvenska timmerhusens konstruktion
  • 2008
  • Bok (övrigt vetenskapligt/konstnärligt)abstract
    • Beskrivning av takkonstruktioner i timmerhus, funktionskrav analys av konstruktiv indelning. Rikligt med förklarande ritningar.
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25.
  • Andersson, Göran, 1957, et al. (författare)
  • Väggar - De nordsvenska timmerhusens konstruktion
  • 2008
  • Bok (övrigt vetenskapligt/konstnärligt)abstract
    • Beskrivning av förutsättningar för liggtimringsmetoden, analys av byggmetodens möjligheter och begränsningar. Förklarande ritningar.
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26.
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27.
  • Andersson, Håkan, 1944, et al. (författare)
  • Astatine-211-labeled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumor model
  • 2003
  • Ingår i: Clin Cancer Res. - 1078-0432. ; 9:10 Pt 2
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: The aim of the study was to establish and refine a preclinical model to alpha-immunoradiotherapy of ovarian cancer. EXPERIMENTAL DESIGN: At-211 was produced by cyclotron irradiation of a bismuth-209 target and isolated using a novel dry distillation procedure. Monoclonal antibodies were radiohalogenated with the intermediate reagent N-succinimidyl 3-(trimethylstannyl)benzoate and characterized in terms of radiochemical yield and in vitro binding properties. In vitro OVCAR-3 cells were irradiated using an external Cobalt-60 beam, as reference, or At-211-albumin and labeled antibody. Growth assays were used to establish cell survival. A Monte Carlo program was developed to simulate the energy imparted and the track length distribution. Nude mice were used for studies of WBC depression, with various activities of Tc-99m antibodies, as reference, and At-211 antibodies. In efficacy studies, OVCAR-3 cells were inoculated i.p., and animals were treated 2 weeks later. The animals were either dissected 6 weeks later or followed-up for long-term survival. RESULTS: A rapid distillation procedure, as well as a rapid and high-yield, single-pot labeling procedure, was achieved. From growth inhibition data, the relative biological effectiveness of the alpha-emission for OVCAR-3 cells was estimated to be approximately 5, which is in the same range as found in vivo for hematological toxicity. At-211 MOv18 was found to effectively inhibit the development of tumors and ascites, also resulting in long-term survival without significant toxic effect. CONCLUSIONS: Use of the short-range, high-linear energy transfer alpha-emitter At-211 conjugated to a surface epitope-recognizing monoclonal antibody appears to be highly efficient without significant toxicity in a mouse peritoneal tumor model, urging a Phase I clinical trial.
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28.
  • Andersson, Håkan, 1944, et al. (författare)
  • Comparison of the therapeutic efficacy of 211At- and 131I-labelled monoclonal antibody MOv18 in nude mice with intraperitoneal growth of human ovarian cancer.
  • 2001
  • Ingår i: Anticancer research. - 0250-7005. ; 21:1A, s. 409-12
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of the present study was to compare the therapeutic efficacy of the alpha-emitter Astatine-211 with the beta-emitter Iodine-131 bound to the specific monoclonal antibody MOv18. The measurements were performed in an ovarian cancer cell line (NIH:OVCAR 3) growing intraperitoneally in nude mice. Two weeks after the intraperitoneal inoculation of 1 x 10(7) cells of the human ovarian cancer cell line NIH:OVCAR-3 twenty mice were treated intraperitoneally with the specific monoclonal antibody MOv-18 labelled with either 211At (310-400 kBq) or 131I (5100-6200 kBq). The pharmacokinetics and biodistribution of labelled antibody in tumour-free animals were studied and the resulting bone marrow dose was estimated. When the mice were treated with 211At-labelled antibody 9 out of 10 mice were free of macro- and microscopic tumour compared to 3 out of 10 when Iodine-131 was used. The equivalent dose to the bone marrow was 2.4-3.1 Sv from 211At- and 3.4-4.1 Sv from 131I-irradiation. The therapeutic efficacy of 211At-labelled specific antibody is very good and, at approximately equivalent bone marrow doses, better than that of 131I.
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29.
  • Andersson, Håkan, 1944, et al. (författare)
  • Intraperitoneal alpha-particle radioimmunotherapy of ovarian cancer patients: pharmacokinetics and dosimetry of (211)At-MX35 F(ab')2--a phase I study.
  • 2009
  • Ingår i: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505. ; 50:7, s. 1153-60
  • Tidskriftsartikel (refereegranskat)abstract
    • The alpha-emitter (211)At labeled to a monoclonal antibody has proven safe and effective in treating microscopic ovarian cancer in the abdominal cavity of mice. Women in complete clinical remission after second-line chemotherapy for recurrent ovarian carcinoma were enrolled in a phase I study. The aim was to determine the pharmacokinetics for assessing absorbed dose to normal tissues and investigating toxicity. METHODS: Nine patients underwent laparoscopy 2-5 d before the therapy; a peritoneal catheter was inserted, and the abdominal cavity was inspected to exclude the presence of macroscopic tumor growth or major adhesions. (211)At was labeled to MX35 F(ab')(2) using the reagent N-succinimidyl-3-(trimethylstannyl)-benzoate. Patients were infused with (211)At-MX35 F(ab')(2) (22.4-101 MBq/L) in dialysis solution via the peritoneal catheter. gamma-Camera scans were acquired on 3-5 occasions after infusion, and a SPECT scan was acquired at 6 h. Samples of blood, urine, and peritoneal fluid were collected at 1-48 h. Hematology and renal and thyroid function were followed for a median of 23 mo. RESULTS: Pharmacokinetics and dosimetric results were related to the initial activity concentration (IC) of the infused solution. The decay-corrected activity concentration decreased with time in the peritoneal fluid to 50% IC at 24 h, increased in serum to 6% IC at 45 h, and increased in the thyroid to 127% +/- 63% IC at 20 h without blocking and less than 20% IC with blocking. No other organ uptakes could be detected. The cumulative urinary excretion was 40 kBq/(MBq/L) at 24 h. The estimated absorbed dose to the peritoneum was 15.6 +/- 1.0 mGy/(MBq/L), to red bone marrow it was 0.14 +/- 0.04 mGy/(MBq/L), to the urinary bladder wall it was 0.77 +/- 0.19 mGy/(MBq/L), to the unblocked thyroid it was 24.7 +/- 11.1 mGy/(MBq/L), and to the blocked thyroid it was 1.4 +/- 1.6 mGy/(MBq/L) (mean +/- SD). No adverse effects were observed either subjectively or in laboratory parameters. CONCLUSION: This study indicates that by intraperitoneal administration of (211)At-MX35 F(ab')(2) it is possible to achieve therapeutic absorbed doses in microscopic tumor clusters without significant toxicity.
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30.
  • Andersson, Jan, et al. (författare)
  • Biologisk recipientkontroll vid kärnkraftverken : Årsrapport för 1999
  • 2000
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Den biologiska recipientkontrollen vid kärnkraftverken 1999 utfördes med smärre undantag enligt fastställda program.ForsmarkLiksom tidigare varierade bottenfaunan i Biotestsjön kraftigt under året. Faunan dominerades av tusensnäckor, medan det var ont om kräftdjur och Östersjömusslor. Totala individtätheter och biomassor var jämförelsevis höga, speciellt under början av året.I fiskena har fångsterna av mört ökat under senare delen av 1990-talet, men var under 1998 och 1999 något lägre än 1997. Mörten rekryteras inte inne i Biotestsjön utan vandrar in genom fiskgallren som små. Fångsten av abborre, som ökade 1998, minskade återigen 1999 med avseende på antal. Tillväxten hos abborrarna var däremot mycket god och den totala vikten hos abborrarna var högre än vid något tidigare fiske.Bottenfaunan på utsidan Biotestsjön ökade i individantal och biomassor på den medeldjupa stationen (16 m vid Länsman) och biomassorna var 1999 de högst uppmätta sedan provtagningarna startade. En liknande ökning i biomassor skedde under 1990-talet även i referensområdet i Finbofjärden.I fiskena efter varmvattenarter ökade fångsterna av abborre kraftigt 1999 både i Forsmarks och i referensområdet i Finbofjärden. Även åldersfördelningen i fångsterna 1999 var likartade med ett stort inslag av tvååriga abborrar, men i referensområdet fanns dessutom ett stort inslag av femåriga abborrar födda 1994.Årsklassen var tidigare också stark i Forsmarksområdet, men äldre fiskar verkar försvinna härifrån, medan abborrarna blir ganska gamla i Finbofjärden.Vid fiskena efter kallvattenarter fanns i fångsterna 1999 ingen torsk varken i Forsmarks- eller Gräsöområdet och fångsterna av sik och hornsimpor var små.Produktionen av årsyngel i skärgården var relativt liten och tillväxten hos abborryngel var medelgod. Även i Biotestsjön var tätheten av abborryngel nå­got lägre än normalt, medan däremot tillväxten hos dessa var den hittills högst uppmätta, vilket torde bero framförallt på höga och för yngeltillväxten optimala temperaturer under sensommar och höst.Vid kontrollen av skador på könsorganen hos abborre i F3:s kanal hade totalt 5% av abborrarna synliga skador på könsorganen 1999, jämfört med 0% 1998 och 20% 1997.OskarshamnFångsterna av abborre och mört i provfiskena i Hamnefjärden har varit höga sedan slutet av 1980-talet. Fångsterna av abborre under sommaren minskade mellan 1998 och 1999. För abborre i vårfisket och för mörten var registrerades små förändringar och båda arterna låg kvar på en relativt hög nivå. Ålfångsterna minskade något för tredje året i rad och det är sannolikt att effekten av utsättningar i slutet av 1980-talet avklingar.Resultatet av abborrens lek i Hamnefjärden har varit svagt efter 1993 och förbättrades inte märkbart under 1999. Andelen stora abborrhonor (>30 cm) medför ögat synliga skador på könsorganen uppgick till 6% i augusti i Hamnefjärden. I Kvädöfjärden påträffades inga skador vid kontroll i oktober. Hos mörten var skadefrekvensen för alla kontrollerade mörthonor 11% i Hamnefjärden och 3% i Kvädöfjärden. Förekomsten av simblåseparasiten Anguillicola crassus hos ål har under senare år varierat mellan 50 och 60% med en svagt vikande tendens. 52% av ålarna var infesterade 1999. Frekvensen av yttre sjukdomssymptom var liten till måttlig och dominerades av hudsår.Abborrfångsterna i den omgivande skärgården och i referensområdet i Kvädöfjärden ökade generellt genom fortsatt rekrytering av abborrar födda 1996 i båda områdena och av abborrar födda 1997 i Kvädöfjärden. Mörten ökade nå­got vid Simpevarp, men trenden där har varit vikande under den senaste tioårsperioden. Mörtfångsterna i Kvädöfjärden har varit små efter 1994 och förändrades i ringa omfattning 1999. Sjukdomsfrekvensen är i allmänhet mycket låg i fångsterna under sommarfisket och var så även 1999. Strömming dominerar fisket efter kallvattenarter under våren och fångsterna låg på en stabil nivå 1996-1999, efter att ha minskat markant i mitten av 1990-talet. De låg dock fortfarande högre än under perioden före 1984. Torsk och rötsimpa förekom rikligt framtill början respektive mitten av 1990-talet, men har därefter fångats mycket sparsamt.Mjukbottenfaunan på transportbottnar i Simpevarp och Kvädöfjärden har ett välutvecklat djursamhälle med dominans för blåmussla och Östersjömussla. Faunan har utvecklats positivt från mitten av 1970-talet, såväl avseende individ- som artrikedom. På de djupare lokalerna i båda områdena har indikationer på syrgasbrist i sedimenten förekommit under flera år på 1990-talet och abundansen har varit relativt låg under hela 1990-talet. Tidigare starka bestånd av vitmärla har försvunnit och dominansen har övertagits av Östersjömussla. De hårda bottnarnas algsamhällen vid Simpevarp tillhör de rikaste i Kalmar län. Betning skadade blåstångsbältena i mitten av 1990-talet, men därefter har en återhämtning skett och sammanhängande bälten fanns 1999 på 14 av 15 provtagningspunkter.BarsebäckProvfisken med ålryssjor gav små fångster av gulål i april på alla lokaler, även om en viss uppgång noterades för lokalerna närmast kraftverket. Ålfångsterna i augusti ökade för alla fem lokalerna, på lokalen närmast kylvattenutsläppet till en rekordhög nivå. För tånglaken finns en allmänt vikande trend under 1990-talet och fångsterna var fortsatt små 1999. Fångsterna av torsk har varit större under 1990-talet än under föregående decennium. Rekordstora torskfångster erhölls för två lokaler i april 1999 och fångsterna på de övriga var oförändrat höga. Ett högsta värde noterades även för en lokal i augusti. För övriga lokaler noterades en tillbakagång från 1998, men nivån var fortsatt hög. Förändringarna för skrubbskädda mellan 1998 och 1999 var små. Denna art har under senare år förekommit sparsamt på våren, då fångsterna domineras av vuxen fisk. Ungfisk har dominerat i augustifisket och har förekommit förhållandevis rikligt från 1995 och framåt. Den mängd småål som följer med kylvattnet in i silstationerna beräknades 1998 uppgå till ca 40 kg. Små mängder glasål förekom under februari och mars. Några kompensationsutsättningar till följd av utslagningen genomfördes ej på grund av tidigare överkompensation.RinghalsEn anlockning av gulål till utsläppsområdet har visats genom provfisken medålryssjor i april och augusti. Fångsterna har varit små under senare år, både i utsläppsområdet och i referensområdet i Vendelsöfjorden. En relativt stor ökning noterades dock för fångsten i utsläppsområdet i augusti 1999. Skärsnultra fångas främst i utsläppsområdet, där fångsterna minskat efter en uppgång i början av 1990-talet till nivåer som är jämförbara med perioden dessförinnan. Minskande fångster har även registrerats för stensnultra under 1990-talets senare del. Denna art har varit vanligast i referensområdet. Förändringarna mellan 1998 och 1999 var dock genomgående positiva. Den mest utpräglade anlockningen till kylvattnet har observerats för strandkrabban. Fångsterna ökade markant nära utsläppet i augusti 1999, medan förändringar i övrigt var små.Arter som föredrar kallare vatten har visats sky det varma kylvattnet. Effekten har varit tydligast för rötsimpa och tånglake. Generellt vikande utveckling har påvisats hos oxsimpa och tånglake under 1990-talet och fångsterna har under senare år stabiliserats på en låg nivå. Aprilfångsterna av oxsimpa i Vendelsö-fjorden steg dock markant i april 1999. Fångsterna av rötsimpa har varit relativt stabila under 1990-talet och har genomgående varit störst i referensområ­det i april. En kraftig tillbakagång registrerades dock mellan 1998 och 1999. En ökning noterades för femtömmad skärlånga, som under senare år främst fångats vid utsläppet under våren. Förekomsten av torsk i ryssjorna påverkas främstav artens rekryteringsframgång. Stora fångster i augusti 1998 dominerades av torskar födda 1997 och 1998 och följdes aven motsvarande uppgång i vårfisket 1999, främst representerad av den senare årsklassen. Fångsterna i augusti detta år var dock små, i synnerhet i utsläppsområdet. Torskägg och torsklarver har förekommit rikligare i intagskanalen under flera år på 1990-talet än tidigare. Detsamma gäller för ägg och larver av plattfiskar, vars förekomst dock steg redan i slutet av 1980-talet. Tätheten av ägg och larver av torsk var dock låg 1999. Plattfiskägg och larver av plattfiskar förekom med måttliga mängder. Larver av rötsimpa och tejstefisk förekommer under vintern och har ökat sin förekomst under senare år. Glasålar förekom sparsamt under stora delar av 1980- och 1990-talen, med undantag för perioder med högre täthet 1981-1983 och 1992-1995.
  •  
31.
  • Andersson, Josefina, et al. (författare)
  • Visible men and elusive women
  • 2011
  • Ingår i: International Journal of Historical Archaeology. - : Springer Science and Business Media LLC. - 1092-7697 .- 1573-7748. ; 15:1, s. 10-29
  • Tidskriftsartikel (refereegranskat)abstract
    • Early gender archaeology formulated two statements: men are visible, women are invisible, and men work in hard materials, women work in soft materials. We discuss these dichotomies in connection with nineteenth-century folklore and an excavated eighteenth-century cottage at a summer-farm. We conclude that much of the gendered order-of-work tasks broke down in pragmatic day-to-day life, especially by women crossing the gender border. However, social chaos was held at bay by ritual acts and magic objects.
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32.
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33.
  • Andersson, Linus, 1979- (författare)
  • Alternativ television : former av kritik i konstnärlig TV-produktion
  • 2012
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • This dissertation analyses social critique, communication critique and aestheticalcritique in television produced by artists. Theoretically it draws on researchon alternative media, TV studies, especially genre analysis and narratology,and media aesthetics. It conducts a text-production study of three examplesof alternative television from the period 2004-2008: ContemporaryArt Center TV (CAC TV): A show produced by the CAC in Vilnius, Lithuaniaand aired on a commercial TV-channel; Good TV who aired video art ona local public access channel in Stockholm, Sweden; and Candyland TV, apirate transmission from an art gallery in central Stockholm.Empirically it builds on TV-texts, web sites and documents, as well asinterviews with participants. Through a study of form and stylistics, relationto conventional genres and modes of narration, it engages in a discussionabout the features of a critical, alternative media text.The study shows how these televisions work in a tradition of alternativetelevision and connects them to tactics and aesthetical forms as found inhistorical examples, but also how this type of formalist media critiquemight inform an understanding of alternative media. From the analysis ofrelations between social and formalist aspects of alternative television, adistinction between alternative as ”alternative worldview” and as ”alternativeexpressions” is suggested, a distinction that contributes to the developmentof theory in the study of alternative media.
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34.
  • Andersson, Leif, et al. (författare)
  • Inventering av violgubbe (Gomphus clavatus) och rödlistade fjälltaggsvampar (Sarcodon spp.) i Västmanlands län 2008.
  • 2010
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Denna inventering av violgubbe (Gomphus clavatus) och rödlistade fjälltaggsvampar (Sarcodon spp.) har utförts på uppdrag av Länsstyrelsen i Västmanlands län. Syftet har varit att öka kunskapen om arternas förekomst i länet samt behovet av skydd och andra åtgärder på de olika lokalerna. Inventeringen har genomförts inom ramen för åtgärdsprogrammen (ÅGP) för bevarande av violgubbe och rödlistade fjälltaggsvampar. Inventeringen har genomförts under september 2008 av Leif Andersson, Kurt- Anders Johansson, Rolf-Göran Carlsson, Stig Jacobsson och Tomas Fasth. Alla kända lokaler för violgubbe och rödlistade fjälltaggsvampar besöktes. Även lokaler för arter med likartade miljökrav har besökts och områden kända för kalkrik berggrund. Under inventeringen har mycel för de eftersökta arterna noterats och koordinater för dessa tagits. Även andra svampar har noterats om än i olika omfattning. Totalt har ett hundratal lokaler besökts varav svampar har noterats på 80 lokaler. Säsongen var mycket god för fjälltaggsvampar, möjligen med undantag för brödtaggsvamp (Sarcodon versipellis). För violgubbe var säsongen något sämre. Totalt noterades violgubbe och/eller rödlistade fjälltaggsvampar på 17 lokaler. Av de 19 kända lokalerna för violgubbe noterades den på sex och en ny lokal upptäcktes. Tidigare var 20 lokaler kända för de olika rödlistade fjälltaggsvamparna varav återfynd gjordes på sex av dessa. Dessutom gjordes 14 nya fynd av rödlistade fjälltaggvampar. Nya för Västmanlands län är blåfotad taggsvamp (Sarcodon glaucopus), sammetstaggsvamp (Sarcodon martioflavus) och den ännu obeskrivna Sarcodon ”modestum”. Den goda svamptillgången 2008 gjorde att särskilt många rödlistade spindelskivlingar noterades. Flera arter är nya för Västmanlands län. Även andra nyfynd av rödlistade svampar för Västmanlands län gjordes t. ex. narrvaxskivlingen (Hygrophorus subviscifer) som noterades på två platser. Totalt gjordes 146 fynd av 42 rödlistade svampar inklusive violgubbe och rödlistade fjälltaggsvampar. Ett antal lokaler och områden har kristalliserats ut som särskilt intressanta för de eftersökta svamparna. I Sala kommun finns många värdefulla områden, särskilt nära tätorten, ofta i närheten av där gruvdrift bedrivits. Särskilt Snarpsätraskogen norr om staden samt områden söder och sydväst om staden hyste många hotade arter. Områdena söder om staden ingår i Salakalkens Natura 2000-område, men skogsnaturtyperna är i dagsläget inte anmälda som naturtyp. I Fagersta och Norberg finns också värdefulla stråk för violgubbe och rödlistade fjälltaggsvampar. Särskilt ska här framhållas Jättåsarna i Fagersta kommun. Flera områdena är inte utpekade som naturvärden eller nyckelbiotoper och saknar också formellt områdesskydd. Ett antal lokaler för de eftersökta svamparna finns i naturreservat och biotopskydd.
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35.
  • Andersson, Magnus, et al. (författare)
  • Mediatization from below
  • 2017
  • Ingår i: Dynamics of mediatization : Institutional change and everyday transformations in a digital age - Institutional change and everyday transformations in a digital age. - 9783319629834 - 9783319629827 ; , s. 35-56
  • Bokkapitel (refereegranskat)
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36.
  • Andersson, Malte, 1941, et al. (författare)
  • ”Minskande befolkning är inte problemet”
  • 2020
  • Ingår i: Dagens Nyheter. ; :1 augusti, DN-debatt
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Nätverket Population Matters Sweden: En uppmärksammad studie i The Lancet pekar mot en lägre befolkningsökning i världen än tidigare prognoser. Men en miljard människor till är fortfarande långt över vad jorden klarar. Befolkningstrenden måste snarare vända neråt, och det kräver åtgärder för att stärka kvinnors rättigheter världen över.
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37.
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38.
  • Andersson, Roland, et al. (författare)
  • Implantable drainage after major abdominal surgery in compromised patients
  • 1990
  • Ingår i: HPB Surgery. - : Hindawi Limited. - 1607-8462 .- 0894-8569. ; 2:4, s. 261-264
  • Tidskriftsartikel (refereegranskat)abstract
    • The risk of superinfection following routine abdominal drainage after major surgery is debated. Especially in patients with malignant diseases and a compromised host defense, this might be a factor increasing morbidity and mortality. During a 3-year period (1986-1988) 41 patients operated on for malignant abdominal conditions received a peritoneal catheter connected to a subcutaneous portal inserted in order to participate in a trial on postoperative intraperitoneal chemotherapy using 5-Fluorouracil. No abdominal drains were inserted. In 15 patients, the subcutaneous portal was used for evacuation of postoperative fluid accumulation within the abdomen. The mean age was 53 (range 41-70) years. Inserted catheters were used for drainage up to 14 days postoperatively. The daily amount of fluid drained varied from 20 to 2,000 ml with a mean of 610 ml/patient and day. One patient required removal of the catheter due to infection around the subcutaneous chamber. Otherwise, the catheter system was not associated with any other complications or complaints. One patient developed a postoperative left subphrenic abscess drained percutaneously by the guidance of ultrasonography, a complication that could not be attributed to the catheter system but merely to the major operation per se. An implantable device for peritoneal access thus also seem useful for drainage of postoperative fluid collection, as evaluated in this preliminary report.
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39.
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40.
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41.
  • Andersson, Stig, 1941, et al. (författare)
  • Excitation and desorption of physisorbed H2 via the 2Σu electron scattering resonance.
  • 2017
  • Ingår i: Journal of Chemical Physics. - : American Institute of Physics (AIP). - 0021-9606 .- 1089-7690. ; 147, s. 114703-1-114703-11
  • Tidskriftsartikel (refereegranskat)abstract
    • Our high-resolution electron energy-loss measurements concern physisorbed H2 and comprise dif- ferential cross sections for the excitation of the internal H2 modes and the H2-surface bonding mode and their combinations and extend over the electron impact energy range of the classical low-energy H2 2Σu resonance. Comparison with corresponding data for the excitation of the internal modes of gas phase H2 reveals that strong elastic electron reflectivity from the Cu(100) substrate profoundly distorts the inelastic scattering pattern for physisorbed H2. We find that this influence can be corrected for and that the resulting peak cross sections agree with the H2 gas phase data, in accordance with theoretical predictions for the excitation of the internal H2 vibration. We have used corrected cross sections for the rotational mode spectra of physisorbed H2, HD, and D2 in a model concerning elec- tron induced desorption via rotation-translation energy conversion. These spectra include transitions from the ground state as well as excited levels of the physisorption potential well. H2 and HD can desorb from all levels while D2, for energetic reason, can only desorb from the excited levels. This model gives a satisfactory account of the observed desorption cross sections and predicts character- istic velocity distributions of the desorbing molecules. The cross section data for H2 and HD reveals that direct bound-free transitions also contribute to the electron induced desorption. 
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42.
  • Andersson, Stig, et al. (författare)
  • Gymnasiekemi 2
  • 2013. - 6
  • Bok (övrigt vetenskapligt/konstnärligt)
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43.
  • Andersson, Stig J, et al. (författare)
  • General practitioners' conceptions about treatment of depression and factors that may influence their practice in this area. A postal survey
  • 2005
  • Ingår i: BMC Family Practice. - : Springer Science and Business Media LLC. - 1471-2296. ; 6:21
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The way GPs work does not appear to be adapted to the needs of depressive patients. Therefore we wanted to examine Swedish GPs' conceptions of depressive disorders and their treatment and GPs' ideas of factors that may influence their manner of work with depressive patients. METHODS: A postal questionnaire to a stratified sample of 617 Swedish GPs. RESULTS: Most respondents assumed antidepressive drugs effective and did not assume that psychotherapy can replace drugs in depression treatment though many of them looked at psychotherapy as an essential complement. Nearly all respondents thought that clinical experiences had great importance in decision situations, but patients' own preferences and official clinical guidelines were also regarded as essential. As influences on their work, almost all surveyed GPs regarded experiences from general practice very important, and a majority also emphasised experiences from private life. Courses arranged by pharmaceutical companies were seen as essential sources of knowledge. A majority thought that psychiatrists did not provide sufficient help, while most respondents perceived they were well backed up by colleagues. CONCLUSION: GPs tend to emphasize experiences, both from clinical work and private life, and overlook influences of collegial dealings and ongoing CME as well as the effects of the pharmaceutical companies' marketing activities. Many GPs appear to need more evidence based knowledge about depressive disorders. Interventions to improve depression management have to be supporting and interactive, and should be combined with organisational reforms to improve co-operation with psychiatrists.
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44.
  • Andersson, Stig J (författare)
  • General Practitioners' Conceptions of Depressive Disorders: Associations with regional sales of antideprssive drugs
  • 2003
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • This thesis emanates from considerations about the inter-regional variation of the sales of antidepressive drugs, and how general practitioners may contribute to that variation. The thesis comprises two data collections utilized for five separate studies. The first data set emerges from interviews with seventeen general practitioners and is used for papers I and II. The first paper reports on general practitioners’ conceptions about depressive disorders and the second on their conceptions on factors that have formed their manner of work. The second data set, used for papers III-V, is from a questionnaire survey completed by 317 general practitioners from municipalities with low, average and high sales of antidepressive drugs, respectively. The questionnaire was designed to evaluate the distribution of conceptions revealed by the preceding interview studies. All general practitioners considered that major depression should be treated with antidepressive drugs, but they differed in their views on treatment of not so severe depressive disorders. Some of them displayed difficulties to distinguish the borderline between normal mood reactions on strain and depressive illness. Nearly all attached great importance to their own clinical experience in treatment decisions. A majority also regarded the patient's attitude to the proposed treatment and official treatment guidelines essential. All general practitioners emphasised individual experience as a base for their professional competence. Pharmaceutical companies play a significant role in continuing education on depression. Consequently, much of general practitioners' conceptions of depression treatment emanate from commercial marketing activities. Significant correlations were observed between sales levels of antidepressive drugs and several questionnaire items. High sales levels were associated with conceptions of high effectiveness of antidepressive drugs, small need of psychotherapy, large emphasis on individual experience, a positive opinion of the work with depressed patients, and frequent attendance to activities arranged by drug companies. These associations strongly suggest that the variation in drug sales partly depends on prevailing conceptions and attitudes vis-à-vis depression in the regional groups of general practitioners.
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45.
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46.
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47.
  • Andersson, Stig Peter, et al. (författare)
  • Thermal conductivity of powders used in continuous casting of steel part 1 : Glassy and crystalline slags
  • 2015
  • Ingår i: Ironmaking & steelmaking. - 0301-9233 .- 1743-2812. ; 42:6, s. 456-464
  • Tidskriftsartikel (refereegranskat)abstract
    • Measurements of the thermal conductivity (λ) and thermal diffusivity (α) have been carried out on samples of Na2O·SiO2 and four mould slags for temperatures between 295 and 1300 K. These measurements were carried out using the transient plane source (TPS) method (295-373 K) and the transient hot wire (THW) technique (295-1300 K) and the laser pulse (LP) or laser flash method in the case of Na2O·SiO2 Values of l295 were very similar (1.07±0.03 W m-1 K-1) and all samples exhibited a maximum at the critical temperature (Tcrit 51040±10 K) beyond which there was a sharp drop in λTHW with increasing temperature. Measurements were also carried out on semi-crystalline samples with increasing λ and fraction of crystalline phase. These samples also exhibited a sharp drop in the thermal conductivity for temperatures above Tcrit and λTcrit was found to be 1.6±0.05 W m-1 K-1. Thermal conductivity (λLP) values calculated from reported thermal diffusivity (αLP) values were in very good agreement with the measured λTHW values for temperatures between 295 K and Tcrit but λLP values did not decrease with increasing temperature above Tcrit (cf. λTHW). Consequently, it was found that λLP≈7λTHW for mould slags.
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48.
  • Andersson, Stig Peter (författare)
  • Thermal conductivity of powders used in continuous casting of steel part 2 : Powders
  • 2015
  • Ingår i: Ironmaking & steelmaking. - 0301-9233 .- 1743-2812. ; 42:6, s. 465-470
  • Tidskriftsartikel (refereegranskat)abstract
    • Measurements of the thermal conductivity of casting powders are needed to determine the magnitude of the vertical heat flux in the powder bed of a continuous casting mould. The thermal conductivities and thermal diffusivities of four mould powders have been determined using the transient plane source (TPS) and the transient hot wire (THW) methods. The values reported in this investigation are in good agreement with the results of earlier studies which used the THW method. However, the results were significantly different from λeff values obtained in thermal insulation tests. This was attributed to the large contribution to λeff from gaseous conduction which arises from the large temperature gradient across the sample. It was found that the thermal conductivity (λpowd) of the powders had a mean value of 0.125±0.025 W m-1 K-1 for the four powders studied; this value is in good agreement with two other studies; it increased as the temperature increased with a mean temperature coefficient of (dλ/dT59×10-5 W m-1 K-2 for the range 295-1100 K and increased as the bulk density increased (λ295=0.010+1.69×10-4ρbulk W m-1 K-1).
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49.
  • Andersson, Sara, et al. (författare)
  • Rehabilitering
  • 2007
  • Ingår i: Nordisk lärobok i audiologi. - Bromma : C. A. Tegnér AB. - 9789163194405 ; , s. 325-389
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • Sjukdomstillstånd och skador i organ och vävnader orsakar diverse funktionella avvikelser, som i sin tur ger upphov till symptom, som personen ifråga kan iaktta och lida av. Dessa orsakar funktionsnedsättningar, som påverkar individens möjligheter att fungera och klara sig i sin dagliga miljö hemma, i olika arbetssituationer och i olika sociala sammanhang.
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50.
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