| 1. |
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| 2. |
- Sarlus, Zmar, 1984-, et al.
(författare)
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Timing and origin of the host rocks to the Malmberget iron oxide-apatite deposit, Sweden
- 2020
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Ingår i: Precambrian Research. - : Elsevier. - 0301-9268 .- 1872-7433. ; 342
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Tidskriftsartikel (refereegranskat)abstract
- The northern Norrbotten region in Sweden hosts abundant iron-oxide apatite (IOA) deposits including Kiirunavaara, the type locality for Kiruna-type deposits, and Malmberget. Felsic and intermediate metavolcanic rocks hosting the Malmberget IOA deposit contain oscillatory zoned zircon which yield magmatic U-Pb SIMS ages of 1885±6 Ma and 1881±6 Ma, respectively. Metamorphic rims on zircon from these rocks yield 1797±7 Ma and 1775±6 Ma, respectively, and record the age of the latest Svecofennian regional metamorphic event in the Gällivare area, tentatively interpreted as regional contact metamorphism. Two granite dikes that cut the ore yield U-Pb zircon emplacement ages of 1790±6 Ma and 1791±7 Ma, respectively, overlapping with the metamorphic overgrowths, and set a lower age limit for ore formation in the Malmberget IOA deposit. Rocks hosting the Malmberget IOA deposit have an alkalic to alkali-calcic affinity with a geochemical signature that favors a continental-arc, transitional to extensional setting. These rocks are suggested to have been generated in a back-arc region, in response to subduction beneath the craton margin retreating to the SW or W. The obtained ages and geochemical signatures of these rocks coincide well with the regionally defined Kiirunavaara group rocks, hosting several other IOA deposits in northern Sweden.
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| 3. |
- Sarlus, Zmar, et al.
(författare)
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Timing of plutonism in the Gällivare area : mplications for Proterozoic crustal development in the northern Norrbotten ore district, Sweden
- 2018
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Ingår i: Geological Magazine. - : Cambridge University Press. - 0016-7568 .- 1469-5081. ; 155:6, s. 1351-1376
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Tidskriftsartikel (refereegranskat)abstract
- Zircon ion probe (secondary-ion mass spectrometry or SIMS) data from a set of intrusive rocks emplaced in the vicinity of major ore bodies, as well as from large igneous intrusions in the Gällivare area, gave the following results: (1) the Dundret ultramafic–mafic layered complex (1883±5 Ma), the Aitik granite (1883±5 Ma), the Nautanen diorite (1870±12 Ma), the Vassaravaara ultramafic–mafic layered complex (1798±4 Ma), the Aitik dolerite (1813±9 Ma), the Bergmästergruvan and Sikträsk syenites (1795±4 Ma and 1801±3 Ma, respectively) and the Naalojärvi granite (1782±5 Ma). These data broadly fall within the ranges 1.89–1.87 Ga (early Svecofennian) and 1.80–1.78 Ga (late Svecofennian), but geochronologically allow further subdivision into pulses at 1885–1880, 1875–1870, 1800 and 1780 Ma. During these events, large layered ultramafic–mafic and felsic plutonic rocks were generated with distinct overlap in time suggesting coeval felsic–mafic magmatism. Results also indicate the presence of inherited c. 1.87 Ga zircon crystals in the plutonic rocks at 1.78 Ga, supporting reworking of the previous crust. These data indicate the importance of mantle-derived mafic underplating in the process of crustal magma generation in the region. The c. 1.88 Ga event that generated ultramafic–mafic layered complexes is tentatively suggested to have played an important role in the formation of the Aitik Cu–Au porphyry system. The later event at c. 1.80 Ga, generating voluminous mafic–felsic units, is suggested to be coupled to the regional iron-oxide-copper-gold (IOCG) overprint.
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| 4. |
- Zamora, Juan Carlos, et al.
(författare)
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Considerations and consequences of allowing DNA sequence data as types of fungal taxa
- 2018
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Ingår i: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
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Tidskriftsartikel (refereegranskat)abstract
- Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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| 5. |
- Johansson, Åke, et al.
(författare)
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Petrogenesis and geotectonic setting of early Svecofennian arc cumulates in the Roslagen area, east-central Sweden
- 2012
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Ingår i: Geological Journal. - : Wiley. - 0072-1050 .- 1099-1034. ; 47:6, s. 557-593
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Tidskriftsartikel (refereegranskat)abstract
- Several intrusions of ultrabasic to basic composition occur in the Roslagen area of east-central Sweden in close spatial and temporal association with the surrounding 1.90-1.87Ga old early orogenic Svecofennian granitoids. An imprecise Sm-Nd WR errorchron yields an age of 1895±71Ma. In spite of the penetrative deformation in the granitoids, the basic-ultrabasic rocks mostly appear undeformed and largely preserve magmatic textures with plagioclase, olivine (in some rock types), orthopyroxene and clinopyroxene, and amphibole as major constituents. The plagioclase is typically very anorthitic (ca. An 90). The Roslagen intrusions range in composition from primitive to evolved (Mg# 80 to 49) but contain only 40-50wt% SiO 2. Many samples are highly elevated in Al 2O 3 (up to 30wt%), CaO (up to 16wt%) and Sr (up to 800ppm), with strongly positive Eu and Sr anomalies, in line with being plagioclase cumulates. Although masked by cumulus effects, the relative trace element contents indicate a volcanic arc signature. The initial Nd isotope composition is homogeneously 'mildly depleted', with ε Nd of +0.3 to +1.1, and the initial Sr isotope composition 'mildly enriched', with ε Sr of +8 to +15. Non-cumulus rocks with small Eu and Sr anomalies can be used to deduce the composition of the parental magma. This LILE- and LREE-enriched and HFSE-depleted high-alumina basalt magma, with Mg# of ca. 50-60 and Ca# of ca. 80, most likely formed by partial melting of mantle material, enriched by fluids in a subduction environment, at 1.9Ga. The cumulate rocks apparently crystallized from a somewhat more evolved water-rich magma with Mg# of ca. 40. Crystallization was followed by the development of late-magmatic to post-magmatic coronas between olivine and plagioclase in the presence of H 2O-rich fluids. The subduction-related setting would make these intrusions Palaeoproterozoic counterparts of Alaskan-type ultramafic intrusions, but they differ from those in being plagioclase enriched, possibly reflecting different levels of exposure.
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| 6. |
- Marsell, Richard, et al.
(författare)
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GSK-3 inhibition by an orally active small molecule increases bone mass in rats
- 2012
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Ingår i: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 50:3, s. 619-627
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Tidskriftsartikel (refereegranskat)abstract
- Glycogen synthase kinase 3β (GSK-3β) actions are central in the canonical Wnt pathway, important in many biological processes and a potential drug target for treating several diseases. It is appreciated that a balanced Wnt canonical signaling is crucial for the maintenance of normal bone mass. In this study we investigated the effects of a potent orally active GSK-3 inhibitor, AZD2858, on bone mass in rats. Treatment (1μM) of human osteoblast cells with AZD2858 in vitro increased β-catenin levels after a short period of time. In rats, oral AZD2858 treatment caused a dose-dependent increase in trabecular bone mass compared to control after a two-week treatment with a maximum effect at a dose of 20mg/kg once daily (total BMC: 172% of control; p<0.001). A small but significant effect was also seen at cortical sites (total BMC: 111% of control; p<0.001). Biomechanical testing demonstrated an increase in both vertebral compression strength at a dose of 20mg/kg once daily (Load at failure: 370% of control, p<0.001) and diaphyseal strength of femora subjected to a three point bending test (Load at failure: 115% of control; p<0.01). Furthermore, histomorphometry showed a dramatic increase in bone formation indices, and serum markers of both bone formation (Osteocalcin, 146% of control; p<0.001) and resorption (CTX, 189% of control; p<0.001) were elevated. Our conclusion is that a GSK-3 inhibitor drug may prove effective as an anabolic strategy in the treatment of diseases characterized by low bone mass, since AZD2858 has extensive bone building effects at predominantly trabecular sites.
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| 7. |
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| 8. |
- Neve, Etienne P A, et al.
(författare)
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Amidoxime Reductase System Containing Cytochrome b5 Type B (CYB5B) and MOSC2 Is of Importance for Lipid Synthesis in Adipocyte Mitochondria
- 2012
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Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 287:9, s. 6307-6317
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Tidskriftsartikel (refereegranskat)abstract
- Reduction of hydroxylamines and amidoximes is important for drug activation and detoxification of aromatic and heterocyclic amines. Such a reductase system was previously found to be of high activity in adipose tissue and liver, and furthermore, in vitro studies using recombinant truncated and purified enzymes suggested the participation of cytochrome b(5) reductase (CYB5R), cytochrome b(5) (CYB5), and molybdenum cofactor sulfurase C-terminal containing 1 and 2 (MOSC1 and -2). Here, we show that purified rat liver outer mitochondrial membrane contains high amidoxime reductase activity and that MOSC2 is exclusively localized to these membranes. Moreover, using the same membrane fraction, we could show direct binding of a radiolabeled benzamidoxime substrate to MOSC2. Following differentiation of murine 3T3-L1 cells into mature adipocytes, the MOSC2 levels as well as the amidoxime reductase activity were increased, indicating that the enzyme is highly regulated under lipogenic conditions. siRNA-mediated down-regulation of MOSC2 and the mitochondrial form of cytochrome b(5) type B (CYB5B) significantly inhibited the reductase activity in the differentiated adipocytes, whereas down-regulation of MOSC1, cytochrome b(5) type A (CYB5A), CYB5R1, CYB5R2, or CYB5R3 had no effect. Down-regulation of MOSC2 caused impaired lipid synthesis. These results demonstrate for the first time the direct involvement of MOSC2 and CYB5B in the amidoxime reductase activity in an intact cell system. We postulate the presence of a novel reductive enzyme system of importance for lipid synthesis that is exclusively localized to the outer mitochondrial membrane and is composed of CYB5B, MOSC2, and a third unknown component (a CYB5B reductase).
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| 9. |
- Andersson, Annika, et al.
(författare)
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Comparison between automatic ribotyping and random amplified polymorphic DNA analysis of Bacillus cereus isolates from the dairy industry
- 1999
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Ingår i: International Journal of Food Microbiology. - 0168-1605 .- 1879-3460. ; 47:42006, s. 147-151
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Tidskriftsartikel (refereegranskat)abstract
- Discrimination by automatic ribotyping and random amplified polymorphic DNA PCR, RAPD, was compared for 40 different B. cereus dairy isolates, 4 different B. mycoides isolates and 6 culture collection strains. RAPD-PCR has previously shown to be useful for tracing contamination routes of B. cereus to milk. Automatic ribotyping using EcoRI and PvuII separated the B. cereus and B. mycoides isolates/strains into 36 different ribotypes. RAPD-typing with primers generated 40 different RAPD-profiles. However, 17 isolates clustered into eight groups, irrespective of the primer and restriction enzyme used, and in all but one case, the isolates with the same pattern were isolated from the same dairy. Automatic ribotyping proved to be a useful, standardized and quick method to discriminate between B. cereus strains, only slightly less discriminatory than RAPD-typing.
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| 10. |
- Andersson, C B M, et al.
(författare)
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Bulk and surface electronic structure of InAs(110)
- 1998
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Ingår i: Surface Science. - 0039-6028 .- 1879-2758. ; 398:3, s. 395-
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Tidskriftsartikel (refereegranskat)abstract
- The InAs(110) cleavage surface has been investigated by angle-resolved photoelectron spectroscopy. A separation between the In 4d(5/2) bulk component and the valence band maximum of 16.8 eV is found to be consistent with normal emission spectra. Experimental energy band dispersions, E-i(k), for the four bulk valence bands are established along the Sigma-line of the bulk Brillouin zone. A bulk band structure calculation utilizing the augmented plane-wave method is made. The experimental and calculated E-i(k) dispersions are found to be in good agreement with each other. E-i(k(parallel to)) dispersions for two surface-related structures are established along the lines <(Gamma)over bar>-(M) over bar and (Y) over bar-(M) over bar of the surface Brillouin zone. (C) 1998 Elsevier Science B.V.
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| 11. |
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| 12. |
- Andersson, C B M, et al.
(författare)
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Surface atomic structure of InAs((111)over-bar)2x2 and InSb((111)over-bar)2x2 studied by core level spectroscopy
- 1996
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Ingår i: Surface Science. - : Elsevier BV. - 0039-6028 .- 1879-2758. ; 347:1-2, s. 199-206
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Tidskriftsartikel (refereegranskat)abstract
- Surface sensitive high resolution core level spectroscopy has been applied to the molecular beam epitaxy grown InAs((111) over bar)2 x 2 and InSb((111) over bar)2 x 2 surfaces. For both systems the In 4d core level consists of one dominating component while the Group V core levels are deconvoluted into four components. This analysis is consistent with a surface model where the topmost layer consists entirely of arsenic or antimony. In this model, Group V atoms form trimers bound to Group V atoms in the first double layer, leaving a single Group V rest atom per unit cell.
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| 13. |
- Andersson, C, et al.
(författare)
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Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes
- 2013
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Ingår i: Pediatric Diabetes. - : Wiley-Blackwell. - 1399-543X .- 1399-5448. ; 14:2, s. 97-105
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Tidskriftsartikel (refereegranskat)abstract
- Andersson C, Vaziri-Sani F, Delli AJ, Lindblad B, Carlsson A, Forsander G, Ludvigsson J, Marcus C, Samuelsson U, Ivarsson SA, Lernmark A, Elding Larsson H, the BDD Study group. Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes. Pediatric Diabetes 2013: 14: 97-105. Objective To establish the diagnostic sensitivity of and the relationships between autoantibodies to all three Zinc transporter 8 (Zinc transporter 8 autoantibody to either one, two, or all three amino acid variants at position 325, ZnT8A) variants to human leukocyte antigen (HLA)-DQ and to autoantibodies to glutamic acid decarboxylase (GADA), insulinoma-associated protein 2 (IA-2A), and insulin (IAA). Methods We analyzed 3165 patients with type 1 diabetes (T1D) in the Better Diabetes Diagnosis study for HLA-DQ genotypes and all six autoantibodies (ZnT8RA, arginine 325 Zinc transporter 8 autoantibody; ZnT8WA, tryptophan 325 Zinc transporter 8 autoantibody; ZnT8QA, glutamine 325 Zinc transporter 8 autoantibody; GADA, IA-2A, and IAA). Results ZnT8A was found in 65% of the patients and as many as 108 of 3165 (3.4%) had 13 ZnT8A alone. None had ZnT8QA alone. Together with GADA (56%), IA-2A (73%), and IAA (33%), 93% of the T1D patients were autoantibody positive. All three ZnT8A were less frequent in children below 2 yr of age (pandlt;0.0001). All three ZnT8A were associated with DQA1-B1*X-0604 (DQ6.4) and DQA1-B1*03-0302 (DQ8). ZnT8WA and ZnT8QA were negatively associated with DQA1-B1*05-02 (DQ2). Conclusions Analysis of ZnT8A increased the diagnostic sensitivity of islet autoantibodies for T1D as only 7% remained islet autoantibody negative. The association between DQ6.4 and all three ZnT8A may be related to ZnT8 antigen presentation by the DQ6.4 heterodimer.
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| 14. |
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| 15. |
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| 16. |
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| 18. |
- Andersson, Ulf, et al.
(författare)
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Performance engineering of GemsFDTD computational electromagnetics solver
- 2012
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Ingår i: Applied Parallel and Scientific Computing. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783642281501 ; , s. 314-324
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Konferensbidrag (refereegranskat)abstract
- Since modern high-performance computer systems consist of many hardware components and software layers, they present severe challenges for application developers who are primarily domain scientists and not experts with continually evolving hardware and system software. Effective tools for performance analysis are therefore decisive when developing performant scalable parallel applications. Such tools must be convenient to employ in the application development process and analysis must be both clear to interpret and yet comprehensive in the level of detail provided. We describe how the Scalasca toolset was applied in engineering the GemsFDTD computational electromagnetics solver, and the dramatic performance and scalability gains thereby achieved.
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| 19. |
- Andersson, Ulf, et al.
(författare)
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The IB/ IHRM interface : Exploring the potential of intersectional theorizing
- 2019
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Ingår i: Journal of World Business. - : Elsevier Inc.. - 1090-9516 .- 1878-5573. ; 54:5
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Tidskriftsartikel (refereegranskat)abstract
- Although the core concepts underlying IB and IHRM provide a common lexicon and epistemology, this commonality is often more implicit than explicit. We highlight not only the common ground but also the lack of critical dialogue between the two fields. This paper asks: What can each field learn from the other? What do scholars from IB learn from IHRM and vice versa? We identify a possible agenda and concerns regarding theory building as a basis for dialogue between the two fields. © 2019
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| 20. |
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| 21. |
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| 22. |
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| 23. |
- Dahl, Caroline, et al.
(författare)
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Ekosystemtjänsternas bidrag till god urban livsmiljö
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Ekosystemtjänster uppmärksammas alltmer som ett viktigt inslag för en hållbar utveckling av städer och samhällen. Dessa handlar inte bara om ett miljö- och biodiversitetsperspektiv, utan också om hur ekosystemen bidrar till människans livsmiljö och stadens attraktivitet, samt de praktiska och rekreativa nyttor som befintlig och anlagd natur kan skapa i den byggda miljön.Denna rapport har tillkommit på Naturvårdsverkets initiativ, vilka också delvis har finansierat den. Arbetet har sammanfallit med ett opinionsbildande projekt, projektlett av Tankesmedjan Movium ochfinansierat av Vinnova, kallat Påverkansplattform för urbana ekosystemtjänster. Båda dessa aktiviteterhar efterfrågat kartläggning av nuläget och redovisningar av lärande exempel, varför vi har valt att arbeta integrerat med aktiviteterna. I rapporten har vi försökt att kombinera generella reflektioner med konkreta exempel. Vi har också valt att hämta lärdomar från såväl praktik som akademi och har bjudit in några av de ledande forskarna från Sveriges lantbruksuniversitet att utifrån sin forskningshorisont kommentera sådant som vi tycker oss kunna konstatera i praktiken. Det kan i något fall bli motsägelsefullt, men så är också frågan kring ekosystemtjänster i urban miljö komplext beskaffad. Som alla komplext beskaffade frågor hyser den därmed inneboende målkonflikter, åtminstone på ett generellt och övergripande plan.I rapporten konstaterar vi att det är viktigt och grundläggande att ekosystemtjänster behandlas som en tillgång för livsmiljöer i staden, och därmed också för arbetet med att planera, gestalta, anlägga och förvalta dessa miljöer. Utgångspunkten för ett sådant arbete behöver vara platsernas förutsättningar och de förväntningar som vi har på dessa miljöer. Möjligen kan det uppfattas som lite motsägelsefullt för en rapport med namnet ”Ekosystemtjänsteras bidrag till en god urban livsmiljö”, men vi är övertygande om att utgångspunkten för arbetet med ekosystemtjänster bör inte vara ekosystemtjänsterna själva, snarare en ökad platsspecifik kunskap och en ökad tydlighet kring samhällets uttalade målsättningar. Varför inleder vi med ett sådant påstående? Jo, för att påminna om att ekosystemtjänsterna utgår från oss människor och tjänsterna svarar mot våra behov. Det är alltså en slags konsumtion av tjänster som vi pratar om och som i all hållbar konsumtion handlar det om att balansera mellan tillgång och efterfrågan. Vi menar alltså att det inte alltid handlar om att maximera uttaget av en viss ekosystemtjänst, utan det handlar snarare om vilket behov som vi har identifierat på en viss plats eller i ett visst sammanhang samt hur ekosystemtjänsterna kan levererar på den platsen utifrån identifierade behov. Det är måhända en hårfin perspektivförskjutning, men vi menar att tar vi inte med oss detta synsätt in i diskussionen om ekosystemtjänster så befarar vi att vi får ett oönskat överutnyttjande av naturens ”gratistjänster”.Det pågår mycket lovvärt arbete i landet för att hitta system och verktyg som strävar efter att finna helhetssyn och mångfunktionalitet i ekosystemtjänsterna. Det finns dock en risk att verktyg blir väl generella när man försöker att fånga upp alla aspekter av hur man kan arbeta med ekosystemtjänsterna. Då riskerar implementeringsglappen också att bli för stora när generella verktyg ska appliceras på en specifik plats. Att istället lära av hur andra har gjort och ta del av varandras erfarenheter kan då vara ett värdefullt komplement och Naturvårdsverket har därför bett Tankesmedjan Movium att ta fram denna exempelsamling. Vår förhoppning är att denna rapport ska hjälpa stadsbyggnadsprocessens olika aktörer och skeden att förstå nyttan med urban natur och att ta in ekosystemtjänsterna i befintliga arbetssätt och processer.
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| 24. |
- Dahlin, Peter, 1974-, et al.
(författare)
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Source character, mixing, fractionation and alkali metasomatismin in Palaeoproterozoic greenstone dykes, Dannemora area, NE Bergslagen region, Sweden
- 2013
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Ingår i: Geological Magazine. - Cambridge : Cambridge Academic. - 0016-7568 .- 1469-5081. ; 151:04, s. 573-590
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Tidskriftsartikel (refereegranskat)abstract
- The geochemical and isotopic characteristics of metamorphosed Svecofennian maficdykes from the Dannemora area in the NE part of the Bergslagen region in central Sweden wereinvestigated and compared to mafic intrusive rocks in their vicinity. The dykes, with an inferred ageof c. 1860–1870 Ma, are calc-alkaline, sub-alkaline and basaltic in composition and have a mixedsubduction and within-plate geochemical affinity. They are the result of mixing of at least three mantlesource components with similar basaltic major element composition, but different concentrations ofincompatible trace elements. Magma M1 is strongly enriched both in Rare Earth Elements (REE)and High-Field-Strength Elements (HFSE); magma M2 is highly enriched in Large-Ion LithophileElements (LILE, except Sr) with only moderate enrichment in HFSE and REE (particularly low inHeavy Rare Earth Elements); and magma M3 is enriched in Sr and has a flat REE profile. MagmaM3 also has a somewhat more positive (depleted) initial εNd value of +1.8, compared to +0.4 to +0.5 for magmas M1 and M2. The magma evolution was controlled by a mixture of fractionation (mainlyaffecting the compatible elements) and mixing, best seen in the incompatible element concentrationsand the Nd isotope data. The basaltic overall composition indicates little or no wholesale contaminationby upper continental crust, but the dykes have undergone later metasomatic changes mainly affectingthe alkali elements.
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| 25. |
- Dahrén, Börje, et al.
(författare)
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Magma plumbing beneath Anak Krakatau volcano, Indonesia : evidence for multiple magma storage regions
- 2012
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Ingår i: Contributions to Mineralogy and Petrology. - : Springer Science and Business Media LLC. - 0010-7999 .- 1432-0967. ; 163:4, s. 631-651
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Tidskriftsartikel (refereegranskat)abstract
- Understanding magma plumbing is essential for predicting the behaviour of explosive volcanoes. We investigate magma plumbing at the highly active Anak Krakatau volcano (Indonesia), situated on the rim of the 1883 Krakatau caldera by employing a suite of thermobarometric models. These include clinopyroxene-melt thermobarometry, plagioclase-melt thermobarometry, clinopyroxene composition barometry and olivine-melt thermometry. Petrological studies have previously identified shallow magma storage in the region of 2–8 km beneath Krakatau, while existing seismic evidence points towards mid- to deep-crustal storage zone(s), at 9 and 22 km, respectively. Our results show that clinopyroxene in Anak Krakatau lavas crystallized at a depth of 7–12 km, while plagioclase records both shallow crustal (3–7 km) and sub-Moho (23–28 km) levels of crystallization. These magma storage regions coincide with well-constrained major lithological boundaries in the crust, implying that magma ascent and storage at Anak Krakatau is strongly controlled by crustal properties. A tandem seismic tomography survey independently identified a separate upper crustal (<7 km) and a lower to mid-crustal magma storage region (>7 km). Both petrological and seismic methods are sensitive in detecting magma bodies in the crust, but suffer from various limitations. Combined geophysical and petrological surveys, in turn, offer increased potential for a comprehensive characterization of magma plumbing at active volcanic complexes.
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| 26. |
- Ekman-Ordeberg, G, et al.
(författare)
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Low molecular weight heparin stimulates myometrial contractility and cervical remodeling in vitro
- 2009
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Ingår i: Acta Obstet Gynecol Scand. - : Wiley. ; 88:9, s. 984-989
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The low molecular weight heparin, Dalteparin, shortens human labor time. The aim of this study was to investigate if the mechanism behind this effect involves myometrial contractility and cervical ripening and if the anticoagulative activity is necessary for its effect. DESIGN: Experimental in vitro study. SETTING: Lund University and Karolinska Institute, Sweden. METHODS: The effect of low molecular weight heparins with or without anticoagulative properties on myometrial contractility was measured in vitro on smooth muscle strips from biopsies obtained at elective cesarean sections. The effects on cervical ripening were assessed in cervical fibroblasts cultured from explants of cervical biopsies obtained at delivery. MAIN OUTCOME MEASURES: Mean force and number of contractions in uterine smooth muscle strips and interleukin-8 (IL-8) secretion in cervical fibroblasts. RESULTS: Myometrial smooth muscle strips pretreated with low molecular weight heparins showed increased contractile activity compared to untreated smooth muscle strips. Secretion of IL-8 from cultured cervical fibroblasts was significantly increased after treatment with low molecular weight heparin. Both these effects were independent of anticoagulative activity of the low molecular weight heparin. CONCLUSIONS: A possible underlying mechanism for the shortened labor time after low molecular weight heparin treatment is enhanced myometrial contractility and an increased IL-8 secretion in cervical fibroblast, mimicking the final cervical ripening in vivo. Our data support the notion that anticoagulant activity is not required to promote labor.
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| 27. |
- Eriksson, S, et al.
(författare)
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Hypertension and thirst outlasting renal vasoconstriction as effects of a brief evaluation of systemic angiotensin II in sheep.
- 1994
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Ingår i: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 150:2, s. 181-8
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Tidskriftsartikel (refereegranskat)abstract
- The influence of 10 min intracarotid (i.c.) and intravenous (i.v.) infusions of angiotensin II (Ang II; 20 pmol kg-1 min-1) on carotid blood pressure (cBP) and renal blood flow (RBF) was studied in unanaesthetized ewes without and with pre-treatment with the alpha 1- and beta-adrenoceptor blocker labetalol. RBF was also monitored during 30 min intracerebroventricular (ICV) infusions of Ang II at 2 pmol kg-1 min-1. The i.c. infusions of Ang II induced about 50 mmHg rise in cBP. A steep decline occurred during 5 min post-infusion, followed by a much slower reduction with the cBP remaining above control level at 40 min post-infusion. The pressure elevation induced by i.v. Ang II was less pronounced but exhibited a similar pattern. Labetalol significantly reduced the pressor response to i.c. as well as i.v. Ang II. The i.c. and i.v. infusions of Ang II conspicuously reduced the RBF regardless of whether the ewes were labetalol-treated or not. At 5 min after the infusions RBF had returned to control level. The ICV infusions did not influence the RBF. Ang II i.c. elicited thirst in 50% of the ewes with the urge to drink remaining at 40 min post-infusion. The dipsogenic response was not reduced by labetalol pretreatment. The results imply that no cerebral component contributes to the reduction in RBF induced by systemic Ang II. However, a centrally mediated action seems to be the cause of the long-lasting post-infusion cBP elevation and dipsogenic response.(ABSTRACT TRUNCATED AT 250 WORDS)
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| 28. |
- Fortuin-de Smidt, Melony C., et al.
(författare)
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Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors : EPIC-CVD case-cohort study
- 2022
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 29:12, s. 1618-1629
-
Tidskriftsartikel (refereegranskat)abstract
- AIMS: This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors.METHODS AND RESULTS: EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal).Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32-64%] and 21% (95%CI 2-44%), with hypercholesterolaemia were 80% (95%CI 55-108%) and 48% (95%CI 22-81%), with hypertension were 80% (95%CI 65-96%) and 49% (95%CI 28-74%), with diabetes were 142% (95%CI 63-260%), and 100% (95%CI 32-204%), and amongst smokers were 152% (95%CI 122-186%) and 109% (95%CI 74-150%).CONCLUSIONS: In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk.
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| 29. |
- Gilg, H. Albert, et al.
(författare)
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Hydrothermal clays in Fe oxide deposits of Norrbotten County, northern Sweden
- 2015
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Ingår i: Programme & Abstracts. ; , s. 127-127
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Europe’s largest Fe oxide deposits are hosted in Palaeoproterozoic supracrustal rock of the Fennoscandian Shield in the northern Norrbotten province, Sweden. Significant clay alteration zones occur at the present land surface and at depth in the Kiirunavaara, Malmberget, Gruvberget, Leveäniemi and Mertainen iron oxide-apatite deposits that are hosted in Svecofennian, mostly intermediate to acid volcanic and subvolcanic rocks, but also in the vicinity of skarn-rich iron formations in the upper part of the older Karelian Greenstone group. A whitish, up to 30 m thick, soft clay alteration zone below glacial till was discovered in 1977 to 1979 by geophysical survey, trenching and drilling in the Vathanvaara area that hosts several prospects in skarn-rich iron formations. The <6 µm fractions of the altered rocks consist predominantly of a dioctahedral Mg-bearing, Al-rich, but Fe-free sodium smectite with minor amounts of an interstratified chlorite-smectite mineral, chlorite, zeolite minerals of the stilbite group and residual albite and actinolite. Whitish to greenish clay alteration zones that can reach a thickness of at least 50 m are encountered in association with the southern part of the Kiirunavaara ore body at a depth of more than 1 km. In part, alteration is pervasive, in part it occurs along multiple fractures or near breccias. The clays can be soft and hard. They occur within the ores and along the contacts with the ore, but also as isolated masses in the hanging wall and the footwall several tens of meters away from the ore. The clay fractions consist mainly of Mg-bearing, Al-rich sodium smectites that shows no signs of interstratification. At the contact, or within the ore, additionally residual green Fe-rich chlorite, phlogopite, talc, albite, sulfides (pyrite and chalcopyrite), and rare calcite in the altered rocks was observed. Stable hydrogen and oxygen isotope data of sodium smectites from Vathanvaara clearly indicate a low-temperature hydrothermal origin of the expandable clay mineral consistent with their close association with stilbite group minerals. The Na-smectite ± stilbite group mineralization at Vathanvaara and Kiirunavaara may be related to regional post-metamorphic hydrothermal events that overprinted Fe ores in the northern Norrbotten area and that have been dated between ~1.62 and ~1.73 Ga. At Kiirunavaara, the earliest clays may even date back to the time of ore emplacement, at ~1.88 Ga. Hydrothermal clays in Fe oxide deposits of Norrbotten County, northern Sweden (PDF Download Available). Available from: https://www.researchgate.net/publication/280722967_Hydrothermal_clays_in_Fe_oxide_deposits_of_Norrbotten_County_northern_Sweden [accessed Apr 15, 2016].
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| 30. |
- Glendor, Ulf, et al.
(författare)
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Direct and indirect time spent on care of dental trauma : a 2-year prospective study of children and adolescents
- 2000
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Ingår i: Endodontics and dental traumatology. - : Wiley. - 0109-2502 .- 1600-4469 .- 1600-9657. ; 16:1, s. 16-23
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Tidskriftsartikel (refereegranskat)abstract
- The aim was to account for the total time spent by professional care-givers (direct time) and by patients and companions engaged as support and help (indirect time) to treat and otherwise attend to children and adolescents with dental trauma to primary and permanent teeth. The study was based on a random sample of 192 children and adolescents with dental traumas reported to an insurance company and prospectively followed up by telephone interviews over a period of 2 years after the trauma episode. On average, direct time represented 16% of total time for all visits for dental trauma to permanent teeth and 11% for trauma to primary teeth. The most extensive type of indirect time was transport time, which took up 30% of the total time spent on injuries to permanent teeth and 36% for injuries to primary teeth. Multiple regression analysis of the impact of dental and demographic injury variables on the time variables showed that complicated trauma was associated with extended time, direct as well as indirect, for permanent and primary teeth injuries. Our estimate of the average relative increase in total time spent by patients and companions in cases of complicated injury to permanent teeth was 117% (95% confidence interval [CI], 52-211) for patients and 112% (95% CI, 42-217) for companions. For transport time a strong predictor was access to a dental clinic near the place of residence. Lack of access could extend the average transport time by 180% (95% CI, 80-335) for patients and 163% (95% CI, 67-317) for their companions in cases of injuries to primary teeth.
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| 31. |
- Gustafsson, Oscar, et al.
(författare)
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Long-wavelength infrared quantum-dot based interband photodetectors
- 2011
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Ingår i: Infrared physics & technology. - : Elsevier BV. - 1350-4495 .- 1879-0275. ; 54:3, s. 287-291
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Tidskriftsartikel (refereegranskat)abstract
- We report on the design and fabrication of (Al)GaAs(Sb)/InAs tensile strained quantum-dot (QD) based detector material for thermal infrared imaging applications in the long-wavelength infrared (LWIR) regime. The detection is based on transitions between confined dot states and continuum states in a type-II band lineup, and we therefore refer to it as a dot-to-bulk (D2B) infrared photodetector with expected benefits including long carrier lifetime due to the type-II band alignment, suppressed Shockley-Read-Hall generation-recombination due to the relatively large-bandgap matrix material, inhibited Auger recombination processes due to the tensile strain and epitaxial simplicity. Metal-organic vapor-phase epitaxy was used to grow multiple (Al)GaAs(Sb) QD layers on InAs substrates at different QD nominal thicknesses, compositions, doping conditions and multilayer periods, and the material was characterized using atomic force and transmission electron microscopy, and Fourier-transform infrared absorption spectroscopy. Dot densities up to 1 x 10(11) cm(-2), 1 x 10(12) cm(-2) and 3 x 10(10) cm(-2) were measured for GaAs, AlGaAs and GaAsSb QDs, respectively. Strong absorption in GaAs, AlGaAs and GaAsSb multilayer QD samples was observed in the wavelength range 6-12 mu m. From the wavelength shift in the spectral absorption for samples with varying QD thickness and composition it is believed that the absorption is due to an intra- valance band transition. From this it is possible to estimate the type-II inter-band transition wavelength, thereby suggesting that (Al)GaAs(Sb) QD/InAs heterostructures are suitable candidates for LWIR detection and imaging.
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| 32. |
- Hakansson, M C, et al.
(författare)
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The electronic structure of In- and As-terminated InAs(001) surfaces
- 1997
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Ingår i: Surface Science. - 0039-6028 .- 1879-2758. ; 374:1-3, s. 73-79
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Tidskriftsartikel (refereegranskat)abstract
- The InAs(001) 2 x 4 and 4 x 2 surfaces have been investigated by angle-resolved photoemission. The X(3) and X(5) points were found to be located 6.0 and 2.7 eV below the valence band maximum, respectively, and the dispersion of bulk bands along the Gamma-X direction in the bulk Brillouin zone were well described by a theoretical calculation. From angle-resolved valence band spectra measured along the high symmetry directions [110] and [1(1) over bar0$], three surface induced stares were identified on both the InAs(001)4 x 2 and the InAs(001)2 x 4 surface. (C) 1997 Elsevier Science B.V.
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| 33. |
- Holtstam, Dan, 1963-, et al.
(författare)
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Arrheniusite-(Ce), CaMg[(Ce7Y3)Ca5](SiO4)3(Si3B3O18)(AsO4)(BO3)F11, a new member of the vicanite group, from the Östanmossa mine, Norberg, Sweden
- 2021
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Ingår i: Canadian Mineralogist. - : Geological and Mineralogical Association of Canada. - 0008-4476 .- 1499-1276. ; 59, s. 177-189
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Tidskriftsartikel (refereegranskat)abstract
- Arrheniusite-(Ce) is a new mineral (IMA 2019-086) from the Östanmossa mine, one of the Bastnäs-type deposits in the Bergslagen ore region, Sweden. It occurs in a metasomatic F-rich skarn, associated with dolomite, tremolite, talc, magnetite, calcite, pyrite, dollaseite-(Ce), parisite-(Ce), bastnäsite-(Ce), fluorbritholite-(Ce) and gadolinite-(Nd). Arrheniusite-(Ce) forms anhedral, greenish-yellow translucent grains, up to 0.8 mm exceptionally. It is optically uniaxial (-), with ω = 1.750(5), ε = 1.725(5), and non-pleochroic in thin section. The calculated density is 4.78(1) g/cm3. Arrheniusite-(Ce) is trigonal, space group R3m, with unit-cell parameters a = 10.8082(3) Å, c = 27.5196(9) Å, and V = 2784.07(14) Å3 for Z = 3. The crystal structure was refined from X-ray diffraction data to R1 = 3.85 for 2286 observed reflections [Fo > 4σ(Fo)]. The empirical formula for the fragment used for the structural study, based on EPMA data and results from the structure refinement, is (Ca0.65As3+0.35)Σ1(Mg0.57Fe2+0.30As5+0.10Al0.03)Σ1[(Ce2.24Nd2.13La0.86Gd0.74Sm0.71Pr0.37)Σ7.05(Y2.76Dy0.26Er0.11Tb0.08Tm0.01Ho0.04Yb0.01)Σ3.27Ca4.14]Σ14.46(SiO4)3[(Si3.26B2.74)Σ6O17.31F0.69][(As5+0.65Si0.22P0.13)Σ1O4](B0.77O3)F11; the ideal formula obtained is CaMg[(Ce7Y3)Ca5](SiO4)3(Si3B3O18)(AsO4)(BO3)F11. Arrheniusite-(Ce) belongs to the vicanite group of minerals, and is distinct from other isostructural members mainly by having a Mg-dominant, octahedrally coordinated site (M6); it can be considered as a Mg-As analog to hundholmenite-(Y). The three-fold coordinated T5 site is partly occupied by B, like in laptevite-(Ce) and vicanite-(Ce). The mineral name honors C.A. Arrhenius (1757–1824), a Swedish officer and chemist, who first discovered gadolinite-(Y), from the famous Ytterby pegmatite quarry.
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| 34. |
- Holtstam, Dan, et al.
(författare)
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Origin of REE mineralization in the Bastnas-type Fe-REE-(Cu-Mo-Bi-Au) deposits, Bergslagen, Sweden
- 2014
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Ingår i: Mineralium Deposita. - : Springer Science and Business Media LLC. - 0026-4598 .- 1432-1866. ; 49:8, s. 933-966
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Tidskriftsartikel (refereegranskat)abstract
- The Bastnas-type deposits, with mineral assemblages of Fe oxides, Ca-Mg silicates, rare earth element (REE) silicates, REE fluorocarbonates, and Cu-Fe-Mo-Bi sulfides, are associated with marble horizons in a strongly Na, K, and/or Mg altered, metavolcanic succession, over a distance of at least 80 km in a SW-NE trending zone in western Bergslagen. Two subtypes occur: (1) enriched (relative to the other type) in light REE (LREE) and Fe, exemplified by the Bastnas and Rodbergsgruvan deposits, and (2) enriched in heavy REE (HREE), Y, Mg, Ca, and F, represented by deposits in the Norberg district. Bastnasite hosts primary fluid H2O-CO2 inclusions with salinities of 6-29 eq. wt% CaCl2 and with total homogenization temperatures (Th-tot) of ca. 300-400 degrees C. Subtype 2 has late-stage fluorite with fluid inclusions that show 1-16 eq. wt% NaCl and Th-tot of ca. 90-150 degrees C. Molybdenite Re-Os ages obtained from three deposits are 1,904 +/- 6, 1,863 +/- 4, and 1,842 +/- 4 Ma. Nd isotopic data from five different REE minerals yielded no defined isochron, but a range in epsilon(Nd) (1.88 Ga) of +0.2 to +1.6. The oxygen isotope values (delta O-18(SMOW)) of dolomite and calcite from the associated REE-mineralized skarn and recrystallized carbonate assemblages lie in the range 6.1-8.6 parts per thousand, overlapping with those of the host marbles. Carbon isotope values (delta C-13(PDB)) show typical magmatic signatures of -6.7 to -4.4 parts per thousand, while the host marbles group around ca. -2.4 parts per thousand. The sulfur isotope (delta S-34(CDT)) values of associated sulfides range between -10.8 and +0.2 parts per thousand. The combined evidence suggests REE mineralization, beginning at 1.9 Ga, from mainly Svecofennian, juvenile magmatic (>400 degrees C) fluids carrying Si, F, Cl, S, CO2, and the REE in addition to other metals; mineralization occurred through reactions with dolomitic layers in the supracrustal units coevally with regional metasomatic alteration associated with fluid circulation through an extensive active volcano-plutonic complex.
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| 35. |
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| 36. |
- Högdahl, Karin, et al.
(författare)
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Continental margin magmatism and migmatisation in the west-central Fennoscandian Shield
- 2008
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Ingår i: Lithos. - : Elsevier BV. - 0024-4937 .- 1872-6143. ; 102:3-4, s. 435-459
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Tidskriftsartikel (refereegranskat)abstract
- The Ljusdal Batholith (LjB) is a major component of the central Svecofennian Domain in Sweden. It is separated from the Bothnian Basin to the north by the 1.82-1.80 Cia crustal-scale Hassela Shear Zone (HSZ). The LjB has emplacement ages of 1.86-1.84 Cia, is mainly alkali-calcic, metaluminous, has epsilon(Nd) values between -0.3 and + 1.2 and was formed in a magmatic arc setting. During the Svecokarelian orogeny the LjB was affected by at least three fold episodes. Large-scale folded screens of migmatised metasedimentary rocks occur in the eastern part of the batholith, and to the north of the HSZ, there is a 50 km wide diatexite belt. The Transition Belt (TrB), consisting of 1.88-1.85 Ga granitoids, is located at the northwestern extension of this belt. A calc-alkaline and peraluminous composition combined with negative epsilon(Nd) values (- 1.7 to -0.8) indicates a large proportion of metasediments in the source for these granitoids. U-Pb SIMS data on zircon rims from migmatites and leucogranites to the north and east of LjB yield ages of 1.87-1.86 Ga, i.e. coeval with the granitoids of the LjB and the TrB. There is thus a close relationship between the LjB, the TrB and the migmatites in both space and time. Syn-migmatitic shearing along the HSZ indicates that a proto-HSZ was initiated already at c. 1.86 Ga, and the location of the proto-HSZ is inferred to be controlled by two older nuclei present in the lower parts of the crust. As crustal-scale shear zone systems are known to act as ascent pathways for sheet-like flow in active orogenies the TrB may represents accumulations of melts that were attracted and extracted by the proto-HSZ and intruded in a block that was not pervasively affected by subsequent shear along the HSZ. An active continental margin setting for the LjB implies subduction at c. 1.86 Ga, and provides a heat source for both the migmatites and the TrB. A later migmatisation at 1.82 Ga has been recorded to the south of the HSZ. Within the LjB the 1.82 Ga stromatic migmatites are folded by F-2 folds, and the fabric is truncated by 1.80 Cia pegmatites.
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| 37. |
- Jonsdottir, Ingibjörg H, 1966, et al.
(författare)
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Voluntary chronic exercise augments in vivo natural immunity in rats.
- 1996
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Ingår i: Journal of applied physiology (Bethesda, Md. : 1985). - 8750-7587. ; 80:5, s. 1799-803
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Tidskriftsartikel (refereegranskat)abstract
- The effect of chronic voluntary exercise on the immune response was studied in spontaneously hypertensive rats. Exercise consisted of voluntary running in wheels for 5 wk, and the mean running distance was 4.2 km/24 h. In vivo cytotoxicity was measured as clearance of injected 51Cr-labeled YAC-1 lymphoma cells from the lungs. The clearance of YAC-1 cells in vivo was significantly increased in runners compared with sedentary controls (P < 0.001). The total number of mononuclear cells in the spleen was significantly decreased in runners compared with controls. Analysis of splenic lymphocyte phenotypes revealed a significantly increased fraction of OX52+/CD5- natural killer cells in runners compared with sedentary controls. In contrast to changes in natural immunity, immunoglobulins G and M levels in serum, the antibody response to antigen in vivo, and the proliferation of splenic T cells in vitro were unchanged. Our data suggest that chronic voluntary exercise augments natural cytotoxicity mechanisms in vivo, whereas splenic T-cell proliferation and the antibody-mediated immune response remain unchanged.
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| 38. |
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| 39. |
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| 40. |
- Lundbäck, Peter, et al.
(författare)
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A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice
- 2016
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Ingår i: Hepatology. - : Ovid Technologies (Wolters Kluwer Health). - 0270-9139 .- 1527-3350. ; 64:5, s. 1699-1710
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Tidskriftsartikel (refereegranskat)abstract
- Acetaminophen (APAP) overdoses are of major clinical concern. Growing evidence underlines a pathogenic contribution of sterile postinjury inflammation in APAP-induced acute liver injury (APAP-ALI) and justifies development of anti-inflammatory therapies with therapeutic efficacy beyond the therapeutic window of the only current treatment option, N-acetylcysteine (NAC). The inflammatory mediator, high mobility group box 1 (HMGB1), is a key regulator of a range of liver injury conditions and is elevated in clinical and preclinical APAP-ALI. The anti-HMGB1 antibody (m2G7) is therapeutically beneficial in multiple inflammatory conditions, and anti-HMGB1 polyclonal antibody treatment improves survival in a model of APAP-ALI. Herein, we developed and investigated the therapeutic efficacy of a partly humanized anti-HMGB1 monoclonal antibody (mAb; h2G7) and identified its mechanism of action in preclinical APAP-ALI. The mouse anti-HMGB1 mAb (m2G7) was partly humanized (h2G7) by merging variable domains of m2G7 with human antibody-Fc backbones. Effector function-deficient variants of h2G7 were assessed in comparison with h2G7 in vitro and in preclinical APAP-ALI. h2G7 retained identical antigen specificity and comparable affinity as m2G7. 2G7 treatments significantly attenuated APAP-induced serum elevations of alanine aminotransferase and microRNA-122 and completely abrogated markers of APAP-induced inflammation (tumor necrosis factor, monocyte chemoattractant protein 1, and chemokine [C-X-C motif] ligand 1) with prolonged therapeutic efficacy as compared to NAC. Removal of complement and/or Fc receptor binding did not affect h2G7 efficacy. Conclusion: This is the first report describing the generation of a partly humanized HMGB1-neutralizing antibody with validated therapeutic efficacy and with a prolonged therapeutic window, as compared to NAC, in APAP-ALI. The therapeutic effect was mediated by HMGB1 neutralization and attenuation of postinjury inflammation. These results represent important progress toward clinical implementation of HMGB1-specific therapy as a means to treat APAP-ALI and other inflammatory conditions. (Hepatology 2016;64:1699-1710).
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| 41. |
- Magnusson, J, et al.
(författare)
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A kinetic study in adults with food hypersensitivity assessed as eosinophil activation in fecal samples
- 2003
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Ingår i: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 33:8
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Immune-mediated food hypersensitivity affecting the gut is difficult to evaluate, and objective tools to diagnose local gastrointestinal (GI) inflammatory reactions are lacking. OBJECTIVES: To determine whether allergic manifestations in adults with a history of food-related GI symptoms could be assessed in feces during symptomatic and non-symptomatic periods, using the surrogate markers, eosinophil cationic protein (ECP), eosinophil protein X (EPX) and myeloperoxidase (MPO). METHODS: Thirteen subjects with food hypersensitivity-related GI symptoms, confirmed by a positive double-blind placebo-controlled food challenge (DBPCFC), were subjected to an open kinetic food challenge design for 6 weeks. Symptoms were recorded and scored during the 3-week study period and stool samples were obtained every day. The surrogate markers ECP, EPX and MPO were measured in the supernatants from feces samples. RESULTS: A significant increase in abdominal pain, distension and flatulence was observed during challenge, with a gradual decrease during elimination diet. Both between days and subjects, EPX levels were more frequently increased compared to ECP and MPO. Individuals with a history of a short duration of symptoms had significantly higher mean levels of EPX and MPO than those with a longer duration of symptoms. CONCLUSIONS: An overall increase in levels of eosinophil markers, in particular EPX, was observed in feces from patients with food-related GI symptoms. However, rather than being a tool to differentiate symptomatic from non-symptomatic periods, EPX might be used for detecting an ongoing clinical or subclinical chronic inflammation, that may have an impact on the patient's clinical course of GI symptoms.
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| 42. |
- Mansouri, Kamel, et al.
(författare)
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CoMPARA : Collaborative Modeling Project for Androgen Receptor Activity
- 2020
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Ingår i: Journal of Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 128:2, s. 1-17
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Endocrine disrupting chemicals (EDCs) are xenobiotics that mimic the interaction of natural hormones and alter synthesis, transport, or metabolic pathways. The prospect of EDCs causing adverse health effects in humans and wildlife has led to the development of scientific and regulatory approaches for evaluating bioactivity. This need is being addressed using high-throughput screening (HTS) in vitro approaches and computational modeling.OBJECTIVES: In support of the Endocrine Disruptor Screening Program, the U.S. Environmental Protection Agency (EPA) led two worldwide consortiums to virtually screen chemicals for their potential estrogenic and androgenic activities. Here, we describe the Collaborative Modeling Project for Androgen Receptor Activity (CoMPARA) efforts, which follows the steps of the Collaborative Estrogen Receptor Activity Prediction Project (CERAPP).METHODS: The CoMPARA list of screened chemicals built on CERAPP's list of 32,464 chemicals to include additional chemicals of interest, as well as simulated ToxCast (TM) metabolites, totaling 55,450 chemical structures. Computational toxicology scientists from 25 international groups contributed 91 predictive models for binding, agonist, and antagonist activity predictions. Models were underpinned by a common training set of 1,746 chemicals compiled from a combined data set of 11 ToxCast (TM)/Tox21 HTS in vitro assays.RESULTS: The resulting models were evaluated using curated literature data extracted from different sources. To overcome the limitations of single-model approaches, CoMPARA predictions were combined into consensus models that provided averaged predictive accuracy of approximately 80% for the evaluation set.DISCUSSION: The strengths and limitations of the consensus predictions were discussed with example chemicals; then, the models were implemented into the free and open-source OPERA application to enable screening of new chemicals with a defined applicability domain and accuracy assessment. This implementation was used to screen the entire EPA DSSTox database of similar to 875,000 chemicals, and their predicted AR activities have been made available on the EPA CompTox Chemicals dashboard and National Toxicology Program's Integrated Chemical Environment.
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| 43. |
- Meklesh, Viktoriia, et al.
(författare)
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Characterization of the Colloidal Properties of Dissolved Organic Matter From Forest Soils
- 2022
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Ingår i: Frontiers in Soil Science. - : Frontiers Media SA. - 2673-8619.
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Tidskriftsartikel (refereegranskat)abstract
- Components of dissolved organic matter (DOM) span from sub-nm molecules to colloidal aggregates of several hundred nm. The colloidal fraction is important for the transport of organic matter and associated elements in the environment, and for the stability of DOM constituents with respect to microbial decomposition. This study focuses on the colloidal properties of DOM extracted from spruce forest soils of a chronosequence. The DOM samples were obtained by common water extraction procedures at 21 and 100°C, respectively. We applied an experimental approach combining chemical analysis with light and X-ray scattering techniques that informed on the colloidal size, charge, and structure of DOM. Results showed that two main types of colloids were present: semi-flexible cylinders and fractal aggregates. The cylinders consisted of carbohydrates, presumably hemicelluloses, while the aggregates were a composite material containing a large fraction of carbohydrates together with aliphatics and clay particles. These fractal aggregates dominated the cold-water extracts whereas the strong increase in total organic carbon by hot-water extraction caused a concomitantly strong increase of semi-flexible cylinders, which became the predominant species. Comparison between the chronosequence soils showed that with increasing forest age, the amount of carbon extracted per gram of soil declined and the concentration of the semi-flexible cylinders decreased. Thus, the distribution between the fractal aggregates and cylinders in the forest soil DOM samples depends on the composition of the soil organic matter and the leaching temperature. Changes in this distribution may have important implications for the reactivity and stability of DOM colloids.
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| 44. |
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| 45. |
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| 46. |
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| 47. |
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| 48. |
- Olsson, L O, et al.
(författare)
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Charge accumulation at InAs surfaces
- 1996
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 76:19, s. 3626-3629
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Tidskriftsartikel (refereegranskat)abstract
- Angle-resolved photoelectron spectroscopy has been used to directly prove the existence of a charge accumulation layer at clean InAs surfaces. The formation of an accumulation layer is shown to be a common property of polar InAs surfaces, with the precise surface Fermi level position above the conduction band minimum determined by the surface geometry. The emission from states in the accumulation layer is studied with respect to its photon energy and angular dependence.
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| 49. |
- Olsson, L O, et al.
(författare)
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Core level and valence-band studies of the (111)2x2 surfaces of InSb and InAs
- 1996
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Ingår i: Physical Review B Condensed Matter. - 0163-1829 .- 1095-3795. ; 53:8, s. 4734-4740
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Tidskriftsartikel (refereegranskat)abstract
- The valence and core electronic surface states on the (111)2X2 surfaces of InSb and InAs have been studied by angle-resolved photoelectron spectroscopy. Similarities in data show that the vacancy-buckling model, which is known to describe the InSb(111)2x2 surface, also applies to InAs(111)2X2. Three surface valence bands are identified and their dispersions are mapped along symmetry directions in the surface Brillouin zone. The In 4d core levels show one surface shifted component while no surface shifted components of the Sb 4d or As 3d core levels could be resolved.
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- Rutanen, H, et al.
(författare)
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1.8 Ga magmatism in southern Finland : strongly enriched mantle and juvenile crustal sources in a post-collisional setting
- 2011
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Ingår i: International Geology Review. - : Informa UK Limited. - 0020-6814 .- 1938-2839. ; 53:14, s. 1622-1683
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Tidskriftsartikel (refereegranskat)abstract
- Whole-rock and isotope geochemistry of six similar to 1.8 Ga post-kinematic intrusions, emplaced along the similar to 1.9 Ga Southern Svecofennian Arc Complex (SSAC) and in the SW part of the Karelian Domain in Finland, was studied. The intrusive age [U-Pb secondary ion mass spectrometer (SIMS)] of one of these, the Petravaara Pluton, was determined as 1811 +/- 6 Ma. Basic-intermediate rocks are alkali-rich (K(2)O + Na(2)O > 4 wt.%) and typically shoshonitic, strongly enriched in large ion lithophile elements and light rare earth elements, but relatively depleted in high field strength elements and heavy rare earth elements. The enrichment is much higher than can be accounted for by crustal contamination and requires previously melt-depleted mantle sources, subjected to variable metasomatism by carbonate-rich fluids and sediment-derived melts. These sources are inferred to consist of phlogopite +/- amphibole-bearing peridotites from depths below the spinel-garnet transition, as shown by the high Ce/Yb ratios. (87)Sr/(86)Sr(1.8 Ga) ratios in the range 0.7027-0.7031 and 'mildly depleted' epsilon(Nd)(1.8 Ga) values (+0.1 to +1.4), with T(DM) values <2.1 Ga, suggest that mantle enrichment was associated with the previous Svecofennian subduction-accretion process, when enriched sub-Svecofennian mantle sections developed, dominantly characterized by (147)Sm/(144)Nd ratios of 0.14-0.17. The associated granitoids are diversified. One group is marginally peraluminous, transitional between I (volcanic-arc) and S (syn-collisional) types, and was derived from mixed igneous and sedimentary, but juvenile Svecofennian source rocks, as supported by near-chondritic epsilon(Nd)(1.8 Ga) and somewhat elevated (87)Sr/(86)Sr(1.8 Ga). The other group is transitional between I and A (within-plate) types in character and had dominantly igneous protoliths. The whole-rock geochemistry and isotopes suggest that the compositional variation between similar to 50 and 70 wt.% SiO(2) may be explained by hybridization between strongly enriched mantle-derived magmas and anatectic granitic magmas from the juvenile Svecofennian crust. One intrusion in the east contains a significant portion of Archaean, mostly igneous protolithic material (epsilon(Nd)(1.8 Ga) = -2.8 and epsilon(Hf)(t) for zircons between +2.8 and -11.9, with an average of -4.9). The similar to 1.8 Ga post-kinematic intrusions were emplaced within the SSAC subsequent to the continental collision with the Volgo-Sarmatia craton from the SE, during a shift from contraction to extension, that is, in a post-collisional setting.
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