SwePub - search: WFRF:(Andersson Yvonne)

Enumeration	Reference	Cover	Find
1.	Andersson, Gunvor, et al. (author) Om yngre barn i socialt arbete 2019. - Andra omarbetade upplagan In: När samhället träder in. Barn, föräldrar och social barnavård.. - 9789144123363 ; , s. 105-132 Book chapter (peer-reviewed)abstract I detta kapitel är syftet att ha fokus på yngre barn, det vill säga 0-12-åringar. I uppgiften att förstå sig på yngre barn ingår att ta i beaktande skillnader i utvecklingsnivå och behov hos spädbarn, förskolebarn och yngre skolbarn. Teoretiska perspektiv från utvecklingspsykologi, barndomssociologi, utvecklingspsykopatologi och utvecklingsekologi är användbara i detta sammanhang. Att se individen i familjen står inte i motsättning till att se familjen i sin omvärld.
2.	Andersson, Gunvor, et al. (author) Vuxna med barndomserfarenheter av samhällsvård 2019. - Andra uppdaterade utgåvan In: När samhället träder in. Barn, föräldrar och socal barnavård. - 9789144123363 ; , s. 185-212 Book chapter (other academic/artistic)abstract Detta kapitel handlar om en grupp barn som fick sina första erfarenheter av samhällsvård i 0-4-årsåldern. Därefter har de en varierande placeringshistoria under barndomen (0-18 år). De har följts upp vid åtta olika tillfällen under barndom och vuxenliv. Detta kapitel fokuserar på hur de hade det i 25-30-årsåldern samt i 35-39-årsåldern, eftersom det är glest med uppföljningar av barn med erfarenhet av samhällsvård så långt in i vuxen ålder. Kapitlet handlar om deras sociala situation, om hälsa och välbefinnande samt om egen familjesituation och relation till föräldrarna. Teoretiska reflektioner avslutar kapitlet.
3.	Andersson-Sköld, Yvonne, 1957-, et al. (author) Coal tar-containing asphalt : Resource or hazardous waste? 2007 In: Journal of Industrial Ecology. - : Wiley-Blackwell. - 1088-1980 .- 1530-9290. ; 11:4, s. 99-116 Journal article (peer-reviewed)abstract Coal tar was used in Sweden for the production of asphalt and for the drenching of stabilization gravel until 1973. The tar has high concentrations of polycyclic aromatic hydrocarbons (PAH), some of which may be strongly carcinogenic. Approximately 20 million tonnes of tar-containing asphalt is present in the public roads in Sweden. Used asphalt from rebuilding can be classified as hazardous waste according to the Swedish Waste Act. The cost of treating the material removed as hazardous waste can be very high due to the large amount that has to be treated, and the total environmental benefit is unclear. The transport of used asphalt to landfill or combustion will affect other environmental targets. The present project, based on three case studies of road projects in Sweden, evaluates the consequences of four scenarios for handling the material: reuse, landfill, biological treatment, and incineration. The results show that reuse of the coal tar-containing materials in new road construction is the most favorable alternative in terms of cost, material use, land use, energy consumption, and air emissions.
4.	Andersson-Sköld, Yvonne, 1957-, et al. (author) Development of the SUNRA Tool to Improve Regional and Local Sustainability of the Transportation Sector 2022 In: Sustainability. - : MDPI AG. - 2071-1050. ; 14:18, s. 11275- Journal article (peer-reviewed)abstract To fulfil the global sustainable development goals (SDGs), achieving sustainable development is becoming urgent, not least in the transportation sector. In response to this, the sustainability framework Sustainability National Road Administrations (SUNRA) was developed to contribute to improving the sustainability performance of national road administrations across Europe. In the present study, the framework has been tested, applied and further developed to be applicable for target setting and follow-up at the project level at both the Swedish Transport Administration (STA) and at municipal levels. The aim was a framework relevant for investment, re-investments, maintenance and operation projects and also to make it more user applicable. The study also investigated how the framework can contribute to sustainability, identified drivers and barriers for applying the framework and examined whether the framework can be applied and adapted to projects of different complexities. The adaptations and developments were done in collaboration between researchers and practitioners. The results show that the framework could easily be used and adapted for investment, re-investment, maintenance and operation projects in the planning stage, as well as for small municipal establishments, construction or reconstruction of residential areas and frequent maintenance. The framework contributes to increased awareness on sustainability, and it provides a common structure and transparency on how infrastructure project goals/targets are set and fulfilled. The framework can also be applied to follow the fulfilment of the goals/targets and thereby adapt the project to better fulfil the goals. Identified barriers include the lack of obligations and lack of experience in using sustainability frameworks.
5.	Arvidsson, Yvonne, 1960, et al. (author) Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract. 2008 In: Endocrine-related cancer. - 1351-0088. ; 15:2, s. 569-81 Journal article (peer-reviewed)abstract We have examined the global gene expression profile of small intestinal carcinoids by microarray analysis. High expression of a number of genes was found including amyloid precursor-like protein 1 (APLP1). Quantitative real-time PCR and western blot analysis demonstrated higher expression of APLP1 in carcinoid metastases relative to primary tumours indicating a role of APLP1 in tumour dissemination. Tissue microarray analysis of gastroentero-pancreatic tumours demonstrated a high frequency of APLP1 expression and a low frequency of APLP2 expression in neuroendocrine (NE) tumours when compared with non-NE tumours at the same sites. Meta-analysis of gene expression data from a large number of tumours outside the gastrointestinal tract confirmed a correlation between APLP1 expression and NE phenotype where high expression of APLP1 was accompanied by downregulation of APLP2 in NE tumours. Cellular localization of APLP1, APLP2 and amyloid precursor protein (APP) in carcinoid cells (GOT1) by confocal microscopy demonstrated partial co-localization with synaptophysin. This suggests that the APP family of proteins is transported to the cell membrane by synaptic microvesicles and that they may influence tumour cell adhesion and invasiveness. We conclude that APLP1 is differentially upregulated in gastrointestinal NE tumours and that APLP1 may be important for the dissemination of small intestinal carcinoids. Identification of APLP1 in NE tumours offers a novel target for treatment and may also serve as a tumour-specific marker.
6.	Björk, Yvonne, et al. (author) Androgens in women after allogeneic hematopoietic cell transplantation : Impact of chronic GvHD and glucocorticoid therapy 2017 In: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 52:3, s. 431-437 Journal article (peer-reviewed)abstract Low androgen levels may contribute to sexual dysfunction in women after allogeneic hematopoietic cell transplantation (alloHCT). However, data on serum androgens in women after alloHCT are limited. The aim of this study was to assess androgen levels and their association with chronic GvHD (cGvHD) and glucocorticoid (GC) therapy. Included were 65 allografted women, 33 with cGvHD, and 23 of these were on GC therapy. Controls were 94 healthy, age-matched women. Supportive study groups were women after autologous HCT (autoHCT; n=20) and non-transplanted women on GC therapy (n=26). Compared with controls, free testosterone (free T) and dehydroepiandrosterone sulfate (DHEAS) levels were lower in both the alloHCT group and GC groups; P<0.0001 and P<0.05, respectively. Androgens in the autoHCT group were similar or higher than controls. In the subgroup of alloHCT patients without cGvHD, free T was similar to controls (7.2 vs 8.6 pmol/L; P=0.42), whereas DHEAS levels was lower than controls (1.7 vs 2.5 μmol/L; P=0.008). Compared with controls, cGvHD without GC (n=10) was associated with lower free T and DHEAS; P=0.004 and P=0.0004, respectively). The lowest androgen levels were seen in women with both cGvHD and GC therapy. In conclusion, low serum androgens were associated with cGvHD and GC therapy, prompting for studies assessing a possible association between low androgens and sexual dysfunction and quality of life in allografted women.
7.	Grechnev, Alexei, et al. (author) A theoretical model for the H-H interactions in metals 2002 In: Phys. Rev. B. ; 66, s. 235104- Journal article (peer-reviewed)
8.	Grechnev, Alexei, et al. (author) H-H interaction and structural phase transition in Ti3SnHx 2002 In: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 66:23, s. 235104- Journal article (peer-reviewed)
9.	Höglin, Viktor, et al. (author) Phase diagram, structures and magnetism of the FeMnP1-xSix-system 2015 In: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 5:11, s. 8278-8284 Journal article (peer-reviewed)abstract The magnetic properties of the (Fe,Mn)(2)(P,Si)-system have been shown to be readily manipulated by small changes in composition. This study surveys the FeMnP1-xSix-system (0.00 <= x <= 1.00) reporting sample syntheses and investigations of crystallographic and magnetic properties using X-ray powder diffraction and magnetic measurements. Two single phase regions exist: the orthorhombic Co2P-type structure (x < 0.15) and the Fe2P-type structure (0.24 <= x < 0.50). Certain compositions have potential for use in magnetocaloric applications.
10.	Höglin, Viktor, et al. (author) Phase diagram, structures and magnetism of the FeMnP1-xSix-system 2015 In: RSC Advances. - 2046-2069. ; 5:11, s. 8278-8284 Journal article (peer-reviewed)abstract The magnetic properties of the (Fe,Mn)2(P,Si)-system have been shown to be readily manipulated by small changes in composition. This study surveys the FeMnP1−xSix-system (0.00 ≤ x ≤ 1.00) reporting sample syntheses and investigations of crystallographic and magnetic properties using X-ray powder diffraction and magnetic measurements. Two single phase regions exist: the orthorhombic Co2P-type structure (x < 0.15) and the Fe2P-type structure (0.24 ≤ x < 0.50). Certain compositions have potential for use in magnetocaloric applications.
11.	Lind, Bo, et al. (author) ”Konsekvensbeskrivning för hantering av tjärhaltiga beläggningsmaterial” 2004 Reports (other academic/artistic)
12.	Lind, Bo, et al. (author) Tjärasfalt vid Spantgatan, Västerås – en konsekvensbeskrivning av olika hanteringssätt 2004 Reports (other academic/artistic)
13.	Marsell, Richard, et al. (author) GSK-3 inhibition by an orally active small molecule increases bone mass in rats 2012 In: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 50:3, s. 619-627 Journal article (peer-reviewed)abstract Glycogen synthase kinase 3β (GSK-3β) actions are central in the canonical Wnt pathway, important in many biological processes and a potential drug target for treating several diseases. It is appreciated that a balanced Wnt canonical signaling is crucial for the maintenance of normal bone mass. In this study we investigated the effects of a potent orally active GSK-3 inhibitor, AZD2858, on bone mass in rats. Treatment (1μM) of human osteoblast cells with AZD2858 in vitro increased β-catenin levels after a short period of time. In rats, oral AZD2858 treatment caused a dose-dependent increase in trabecular bone mass compared to control after a two-week treatment with a maximum effect at a dose of 20mg/kg once daily (total BMC: 172% of control; p<0.001). A small but significant effect was also seen at cortical sites (total BMC: 111% of control; p<0.001). Biomechanical testing demonstrated an increase in both vertebral compression strength at a dose of 20mg/kg once daily (Load at failure: 370% of control, p<0.001) and diaphyseal strength of femora subjected to a three point bending test (Load at failure: 115% of control; p<0.01). Furthermore, histomorphometry showed a dramatic increase in bone formation indices, and serum markers of both bone formation (Osteocalcin, 146% of control; p<0.001) and resorption (CTX, 189% of control; p<0.001) were elevated. Our conclusion is that a GSK-3 inhibitor drug may prove effective as an anabolic strategy in the treatment of diseases characterized by low bone mass, since AZD2858 has extensive bone building effects at predominantly trabecular sites.
14.	Rydell, Bengt, et al. (author) Geotechnical decision basis for sustainable coastal areas 2008 In: [Host publication title missing]. - 9788360261071 Conference paper (peer-reviewed)abstract There are several urban areas close to the coast or other waterways that may be adversely affected by erosion, flooding and slope instability. Global climate change including sea level rise, increased precipitation and more intense and damaging storms will increase the threats of natural hazards in several areas. Mitigating and adapting to these risks in urban areas are huge challenges for society. There is a need for a proper geotechnical decision basis to build a long-term sustainable society in terms of economic, social and environmental aspects. By incorporating coastal hazard and risk mapping into spatial planning new developments can be diverted away from threatened areas and by adaptation measures risks in existing urban areas can be reduced.
15.	Thorsson, Sofia, 1972, et al. (author) Adapting cities to climate induced risks - a coordinated approach 2011 In: Climate and Construction. ; , s. 173-180 Conference paper (peer-reviewed)abstract In an era of changing climate there is a growing interest to create resilient cities, which can absorb and manage climate induce risks, such as heat waves and natural hazards (flooding, landslides etc). The increased frequencies and magnitudes of these climate hazards are expected to have a major impact on society. In order to maintain risks to society at acceptable levels, measures to reduce the vulnerability need to be taken. Such measures may, however, have significant non-expected and non-wanted impacts elsewhere on society. The need of holistic planning strategies becomes apparent. The overall aim of this new transdisciplinary research project is to develop knowledge and methods that enable an integrated assessment of the impact of climate induced risks on society. The free-port area in Gothenburg, Sweden, will has been selected for a case study that will sharpen both the individual scientific methods and the interdisciplinary and intersectoral cooperation and integration. The project brings together experts in urban climate, atmospheric science, natural risk assessment, stratified vulnerability and multi-criteria analyses with local city planners in an integrated research effort. Strategic plans for climate adaptation will be developed and proposed. The stakeholder involvement will promote transfer of knowledge and applicability of results.
16.	Aalberg, Laura, et al. (author) Development of a harmonised method for the profiling of amphetamines : I. Synthesis of standards and compilation of analytical data 2005 In: Forensic Science International. - : Elsevier BV. - 0379-0738 .- 1872-6283. ; 149:2-3, s. 219-229 Journal article (peer-reviewed)abstract Reference material was synthesised for 21 substances that are frequently present as synthetic impurities, i.e. by-products, in illicitly produced amphetamine. Each of these substances is a typical by-product for at least one of the three approaches most often used to synthesise amphetamine, namely, the Leuckart, the reductive amination of benzyl methyl ketone, and the nitrostyrene routes. A large body of data on the substances was recorded, including the following: mass spectra, ultraviolet spectra, Fourier transform infrared spectra, infrared spectra in gas phase, and 1H NMR and 13C NMR spectra. © 2004 Elsevier Ireland Ltd. All rights reserved.
17.	Abdalla, H., et al. (author) A search for new supernova remnant shells in the Galactic plane with HESS 2018 In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 612 Journal article (peer-reviewed)abstract A search for new supernova remnants (SNRs) has been conducted using TeV gamma-ray data from the H.E.S.S. Galactic plane survey. As an identification criterion, shell morphologies that are characteristic for known resolved TeV SNRs have been used. Three new SNR candidates were identified in the H.E.S.S. data set with this method. Extensive multiwavelength searches for counterparts were conducted. A radio SNR candidate has been identified to be a counterpart to HESS J1534-571. The TeV source is therefore classified as a SNR. For the other two sources, HESS J1614-518 and HESS J1912 + 101, no identifying counterparts have been found, thus they remain SNR candidates for the time being. TeV-emitting SNRs are key objects in the context of identifying the accelerators of Galactic cosmic rays. The TeV emission of the relativistic particles in the new sources is examined in view of possible leptonic and hadronic emission scenarios, taking the current multiwavelength knowledge into account.
18.	Abdalla, H., et al. (author) Characterising the VHE diffuse emission in the central 200 parsecs of our Galaxy with HESS 2018 In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 612 Journal article (peer-reviewed)abstract The diffuse very high-energy (VHE; > 100 GeV) gamma-ray emission observed in the central 200 pc of the Milky Way by H.E.S.S. was found to follow dense matter distribution in the central molecular zone (CMZ) up to a longitudinal distance of about 130 pc to the Galactic centre (GC), where the flux rapidly decreases. This was initially interpreted as the result of a burst-like injection of energetic particles 104 yr ago, but a recent more sensitive H.E.S.S. analysis revealed that the cosmic-ray (CR) density profile drops with the distance to the centre, making data compatible with a steady cosmic PeVatron at the GC. In this paper, we extend this analysis to obtain, for the first time, a detailed characterisation of the correlation with matter and to search for additional features and individual gamma-ray sources in the inner 200 pc. Taking advantage of 250 h of H.E.S.S. data and improved analysis techniques, we perform a detailed morphology study of the diffuse VHE emission observed from the GC ridge and reconstruct its total spectrum. To test the various contributions to the total gamma-ray emission, we used an iterative 2D maximum-likelihood approach that allows us to build a phenomenological model of the emission by summing a number of different spatial components. We show that the emission correlated with dense matter covers the full CMZ and that its flux is about half the total diffuse emission flux. We also detect some emission at higher latitude that is likely produced by hadronic collisions of CRs in less dense regions of the GC interstellar medium. We detect an additional emission component centred on the GC and extending over about 15 pc that is consistent with the existence of a strong CR density gradient and confirms the presence of a CR accelerator at the very centre of our Galaxy. We show that the spectrum of full ridge diffuse emission is compatible with that previously derived from the central regions, suggesting that a single population of particles fills the entire CMZ. Finally, we report the discovery of a VHE gamma-ray source near the GC radio arc and argue that it is produced by the pulsar wind nebula candidate G0.13-0.11.
19.	Abdalla, H., et al. (author) Characterizing the γ-ray long-term variability of PKS2155 304 with HESS and Fermi-LAT 2017 In: Astronomy and Astrophysics. - : The European Southern Observatory. - 0004-6361 .- 1432-0746. ; 598 Journal article (peer-reviewed)abstract Studying the temporal variability of BL Lac objects at the highest energies provides unique insights into the extreme physical processes occurring in relativistic jets and in the vicinity of super-massive black holes. To this end, the long-term variability of the BL Lac object PKS 2155-304 is analyzed in the high (HE, 100MeV < E < 300 GeV) and very high energy (VHE, E > 200 GeV) gamma-ray domain. Over the course of similar to 9 yr of H. E. S. S. observations the VHE light curve in the quiescent state is consistent with a log-normal behavior. The VHE variability in this state is well described by flicker noise (power-spectral-density index βVHE = 1 .10+ 0.10-0,13) on timescales larger than one day. An analysis of similar to 5.5 yr of HE Fermi-LAT data gives consistent results (βHE = 1 .20+ 0.21-0.23, on timescales larger than 10 days) compatible with the VHE findings. The HE and VHE power spectral densities show a scale invariance across the probed time ranges. A direct linear correlation between the VHE and HE fluxes could neither be excluded nor firmly established. These long-term-variability properties are discussed and compared to the red noise behavior (beta similar to 2) seen on shorter timescales during VHE-flaring states. The difference in power spectral noise behavior at VHE energies during quiescent and flaring states provides evidence that these states are influenced by different physical processes, while the compatibility of the HE and VHE long-term results is suggestive of a common physical link as it might be introduced by an underlying jet-disk connection.
20.	Abdalla, H., et al. (author) First limits on the very-high energy gamma-ray afterglow emission of a fast radio burst HESS observations of FRB 150418 2017 In: Astronomy and Astrophysics. - : The European Southern Observatory (ESO). - 0004-6361 .- 1432-0746. ; 597 Journal article (peer-reviewed)abstract Aims. Following the detection of the fast radio burst FRB150418 by the SUPERB project at the Parkes radio telescope, we aim to search for very-high energy gamma-ray afterglow emission. Methods. Follow-up observations in the very-high energy gamma-ray domain were obtained with the H.E.S.S. imaging atmospheric Cherenkov telescope system within 14.5 h of the radio burst. Results. The obtained 1.4 h of gamma-ray observations are presented and discussed. At the 99% C.L. we obtained an integral upper limit on the gamma-ray flux of Phi(gamma)(E > 350 GeV) < 1.33 x 10(-8) m(-2) s(-1). Differential flux upper limits as function of the photon energy were derived and used to constrain the intrinsic high-energy afterglow emission of FRB 150418. Conclusions. No hints for high-energy afterglow emission of FRB 150418 were found. Taking absorption on the extragalactic background light into account and assuming a distance of z = 0 : 492 based on radio and optical counterpart studies and consistent with the FRB dispersion, we constrain the gamma-ray luminosity at 1 TeV to L < 5 : 1 x 10(47) erg/s at 99% C.L.
21.	Abdalla, H., et al. (author) Gamma-ray blazar spectra with HESS II mono analysis : The case of PKS2155-304 and PG1553+113 2017 In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 600 Journal article (peer-reviewed)abstract Context. The addition of a 28 m Cherenkov telescope (CT5) to the H.E.S.S. array extended the experiment's sensitivity to lower energies. The lowest energy threshold is obtained using monoscopic analysis of data taken with CT5, providing access to gamma-ray energies below 100 GeV for small zenith angle observations. Such an extension of the instrument's energy range is particularly beneficial for studies of active galactic nuclei with soft spectra, as expected for those at a redshift >= 0.5. The high-frequency peaked BL Lac objects PKS 2155-304 (z = 0.116) and PG 1553 + 113 (0.43 < z < 0.58) are among the brightest objects in the gamma-ray sky, both showing clear signatures of gamma-ray absorption at E > 100 GeV interpreted as being due to interactions with the extragalactic background light (EBL). Aims. The aims of this work are twofold: to demonstrate the monoscopic analysis of CT5 data with a low energy threshold, and to obtain accurate measurements of the spectral energy distributions (SED) of PKS 2155-304 and PG 1553 + 113 near their SED peaks at energies approximate to 100 GeV. Methods. Multiple observational campaigns of PKS 2155 304 and PG 1553 + 113 were conducted during 2013 and 2014 using the full H.E.S.S. II instrument (CT1-5). A monoscopic analysis of the data taken with the new CT5 telescope was developed along with an investigation into the systematic uncertainties on the spectral parameters which are derived from this analysis. Results. Using the data from CT5, the energy spectra of PKS 2155 304 and PG 1553 + 113 were reconstructed down to conservative threshold energies of 80 GeV for PKS 2155 304, which transits near zenith, and 110 GeV for the more northern PG 1553 + 113. The measured spectra, well fitted in both cases by a log-parabola spectral model ( with a 5.0 similar to statistical preference for non-zero curvature for PKS 2155 304 and 4.5 sigma for PG 1553+113), were found consistent with spectra derived from contemporaneous Fermi-LAT data, indicating a sharp break in the observed spectra of both sources at E approximate to 100 GeV. When corrected for EBL absorption, the intrinsic H.E.S.S. II mono and Fermi-LAT spectrum of PKS 2155 304 was found to show significant curvature. For PG 1553+113, however, no significant detection of curvature in the intrinsic spectrum could be found within statistical and systematic uncertainties.
22.	Abdalla, H., et al. (author) HESS discovery of very high energy gamma-ray emission from PKS 0625-354 2018 In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press. - 0035-8711 .- 1365-2966. ; 476:3, s. 4187-4198 Journal article (peer-reviewed)abstract PKS 0625-354 (z = 0.055) was observed with the four High Energy Stereoscopic System (H.E.S.S.) telescopes in 2012 during 5.5 h. The source was detected above an energy threshold of 200 GeV at a significance level of 6.1 sigma. No significant variability is found in these observations. The source is well described with a power-law spectrum with photon index Gamma = 2.84 +/- 0.50(stat) +/- 0.10(syst) and normalization (at E-0 = 1.0 TeV) N-0(E-0)=(0.58 +/- 0.22(stat) +/- 0.12(syst)) x 10(-12) TeV-1 cm(-2) s(-1). Multiwavelength data collected with Fermi-LAT, Swift-XRT, Swift-UVOT, ATOM and WISE are also analysed. Significant variability is observed only in the Fermi-LAT gamma-ray and Swift-XRT X-ray energy bands. Having a good multiwavelength coverage from radio to very high energy, we performed a broad-band modelling from two types of emission scenarios. The results from a one zone lepto-hadronic and a multizone leptonic models are compared and discussed. On the grounds of energetics, our analysis favours a leptonic multizone model. Models associated to the X-ray variability constraint support previous results, suggesting a BL Lac nature of PKS 0625-354 with, however, a large-scale jet structure typical of a radio galaxy.
23.	Abdalla, H., et al. (author) HESS Limits on Linelike Dark Matter Signatures in the 100 GeV to 2 TeV Energy Range Close to the Galactic Center 2016 In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 117:15 Journal article (peer-reviewed)abstract A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l = -1.5 degrees, b = 0 degrees and for a dark matter profile centered at this location) previously reported in Fermi-LAT data. This new analysis overlaps significantly in energy with previous Fermi-LAT and H.E.S.S. results. No significant excess associated with dark matter annihilations was found in the energy range of 100 GeV to 2 TeV and upper limits on the gamma-ray flux and the velocity weighted annihilation cross section are derived adopting an Einasto dark matter halo profile. Expected limits for present and future large statistics H.E.S.S. observations are also given.
24.	Abdalla, H., et al. (author) HESS observations of RX J1713.7-3946 with improved angular and spectral resolution : Evidence for gamma-ray emission extending beyond the X-ray emitting shell 2018 In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 612 Journal article (peer-reviewed)abstract Supernova remnants exhibit shock fronts (shells) that can accelerate charged particles up to very high energies. In the past decade, measurements of a handful of shell-type supernova remnants in very high-energy gamma rays have provided unique insights into the acceleration process. Among those objects, RX J1713.7-3946 (also known as G347.3-0.5) has the largest surface brightness, allowing us in the past to perform the most comprehensive study of morphology and spatially resolved spectra of any such very high-energy gamma-ray source. Here we present extensive new H.E.S.S. measurements of RX J1713.7-3946, almost doubling the observation time compared to our previous publication. Combined with new improved analysis tools, the previous sensitivity is more than doubled. The H.E.S.S. angular resolution of 0.048 degrees (0.036 degrees above 2 TeV) is unprecedented in gamma-ray astronomy and probes physical scales of 0.8 (0.6) parsec at the remnant's location. The new H. E. S. S. image of RX J1713.7-3946 allows us to reveal clear morphological di ff erences between X-rays and gamma rays. In particular, for the outer edge of the brightest shell region, we find the first ever indication for particles in the process of leaving the acceleration shock region. By studying the broadband energy spectrum, we furthermore extract properties of the parent particle populations, providing new input to the discussion of the leptonic or hadronic nature of the gamma-ray emission mechanism.
25.	Abdalla, H., et al. (author) Measurement of the EBL spectral energy distribution using the VHE gamma-ray spectra of HESS blazars 2017 In: Astronomy and Astrophysics. - : The European Southern Observatory (ESO). - 0004-6361 .- 1432-0746. ; 606 Journal article (peer-reviewed)abstract Very high-energy gamma rays (VHE, E greater than or similar to 100 GeV) propagating over cosmological distances can interact with the low-energy photons of the extragalactic background light (EBL) and produce electron-positron pairs. The transparency of the Universe to VHE gamma rays is then directly related to the spectral energy distribution (SED) of the EBL. The observation of features in the VHE energy spectra of extragalactic sources allows the EBL to be measured, which otherwise is very difficult. An EBL model-independent measurement of the EBL SED with the H.E.S.S. array of Cherenkov telescopes is presented. It was obtained by extracting the EBL absorption signal from the reanalysis of high-quality spectra of blazars. From H.E.S.S. data alone the EBL signature is detected at a significance of 9.5 sigma, and the intensity of the EBL obtained in different spectral bands is presented together with the associated gamma-ray horizon.
26.	Abdalla, H., et al. (author) Systematic search for very-high-energy gamma-ray emission from bow shocks of runaway stars 2018 In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 612 Journal article (peer-reviewed)abstract Context. Runaway stars form bow shocks by ploughing through the interstellar medium at supersonic speeds and are promising sources of non-thermal emission of photons. One of these objects has been found to emit non-thermal radiation in the radio band. This triggered the development of theoretical models predicting non-thermal photons from radio up to very-high-energy (VHE, E >= 0.1 TeV) gamma rays. Subsequently, one bow shock was also detected in X-ray observations. However, the data did not allow discrimination between a hot thermal and a non-thermal origin. Further observations of different candidates at X-ray energies showed no evidence for emission at the position of the bow shocks either. A systematic search in the Fermi-LAT energy regime resulted in flux upper limits for 27 candidates listed in the E-BOSS catalogue. Aims. Here we perform the first systematic search for VHE gamma-ray emission from bow shocks of runaway stars. Methods. Using all available archival H.E.S.S. data we search for very-high-energy gamma-ray emission at the positions of bow shock candidates listed in the second E-BOSS catalogue release. Out of the 73 bow shock candidates in this catalogue, 32 have been observed with H.E.S.S. Results. None of the observed 32 bow shock candidates in this population study show significant emission in the H.E.S.S. energy range. Therefore, flux upper limits are calculated in five energy bins and the fraction of the kinetic wind power that is converted into VHE gamma rays is constrained. Conclusions. Emission from stellar bow shocks is not detected in the energy range between 0.14 and 18 TeV. The resulting upper limits constrain the level of VHE gamma-ray emission from these objects down to 0.1-1% of the kinetic wind energy.
27.	Abdalla, H., et al. (author) The population of TeV pulsar wind nebulae in the HESS Galactic Plane Survey 2018 In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 612 Journal article (peer-reviewed)abstract The nine-year H.E.S.S. Galactic Plane Survey (HGPS) has yielded the most uniform observation scan of the inner Milky Way in the TeV gamma-ray band to date. The sky maps and source catalogue of the HGPS allow for a systematic study of the population of TeV pulsar wind nebulae found throughout the last decade. To investigate the nature and evolution of pulsar wind nebulae, for the first time we also present several upper limits for regions around pulsars without a detected TeV wind nebula. Our data exhibit a correlation of TeV surface brightness with pulsar spindown power (E) over dot. This seems to be caused both by an increase of extension with decreasing (E) over dot, and hence with time, compatible with a power law R-PWN((E) over dot) similar to(E) over dot(0.65 +/- 0.20), and by a mild decrease of TeV gamma-ray luminosity with decreasing (E) over dot, compatible with L-1 (10 TeV) similar to (E) over dot(0.59 +/- 0.21). We also find that the off sets of pulsars with respect to the wind nebula centre with ages around 10 kyr are frequently larger than can be plausibly explained by pulsar proper motion and could be due to an asymmetric environment. In the present data, it seems that a large pulsar off set is correlated with a high apparent TeV efficiency L1- 10 TeV / (E) over dot. In addition to 14 HGPS sources considered firmly identified pulsar wind nebulae and 5 additional pulsar wind nebulae taken from literature, we find 10 HGPS sources that are likely TeV pulsar wind nebula candidates. Using a model that subsumes the present common understanding of the very high-energy radiative evolution of pulsar wind nebulae, we find that the trends and variations of the TeV observables and limits can be reproduced to a good level, drawing a consistent picture of present-day TeV data and theory.
28.	Abdalla, H., et al. (author) The supernova remnant W49B as seen with HESS and Fermi-LAT 2018 In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 612 Journal article (peer-reviewed)abstract The supernova remnant (SNR) W49B originated from a core-collapse supernova that occurred between one and four thousand years ago, and subsequently evolved into a mixed-morphology remnant, which is interacting with molecular clouds (MC). Gamma-ray observations of SNR-MC associations are a powerful tool to constrain the origin of Galactic cosmic rays, as they can probe the acceleration of hadrons through their interaction with the surrounding medium and subsequent emission of non-thermal photons. We report the detection of a gamma-ray source coincident with W49B at very high energies (VHE; E > 100 GeV) with the H.E.S.S. Cherenkov telescopes together with a study of the source with five years of Fermi-LAT high-energy gamma-ray (0.06-300 GeV) data. The smoothly connected, combined source spectrum, measured from 60 MeV to multi-TeV energies, shows two significant spectral breaks at 304 +/- 20 MeV and 8.4(-2.5)(+2.5) GeV; the latter is constrained by the joint fit from the two instruments. The detected spectral features are similar to those observed in several other SNR-MC associations and are found to be indicative of gamma-ray emission produced through neutral-pion decay.
29.	Adesam, Yvonne, 1975, et al. (author) A lexical resource for computational historical linguistics 2021 In: The Swedish FrameNet++. Harmonization, integration, method development and practical language technology applications. - Amsterdam / Philadelphia : John Benjamins Publishing Company. - 1567-8202. - 978 90 272 5848 9 ; , s. 98-121 Book chapter (peer-reviewed)abstract In this chapter we present the diachronic dimension of Swedish FrameNet++. We describe the historical lexical resources currently available for Swedish, linked to the Contemporary Swedish lexicon Saldo. We present a case study of how interlinking the dictionaries simultaneously allows us to study lexical change. We also present a method of linking text words to lexicon entries, facilitating interactive exploration of historical texts. Diachronical language resources present both a high-variation challenge from a wider language technology perspective, and an interesting object of linguistic study. While a number of improvements of the parts of the diachronic lexical macroresource are still needed, this resource is invaluable for analysing and accessing historical texts, as well as for both synchronic historical and diachronic lexical studies.
30.	Adesam, Yvonne, 1975, et al. (author) Computer-aided Morphology Expansion for Old Swedish 2014 In: Proceedings of the Ninth International Conference on Language Resources and Evaluation (LREC'14) May 26-31, 2014 Reykjavik, Iceland. - 9782951740884 ; , s. 1102-1105 Conference paper (peer-reviewed)abstract In this paper we describe and evaluate a tool for paradigm induction and lexicon extraction that has been applied to Old Swedish. The tool is semi-supervised and uses a small seed lexicon and unannotated corpora to derive full inflection tables for input lemmata. In the work presented here, the tool has been modified to deal with the rich spelling variation found in Old Swedish texts. We also present some initial experiments, which are the first steps towards creating a large-scale morphology for Old Swedish.
31.	Adesam, Yvonne, 1975, et al. (author) Språkteknologi för svenska språket genom tiderna 2016 In: Kungliga Skytteanska Samfundets Handlingar. - Umeå : Institutionen för språkstudier, Umeå universitet & Kungl. Skytteanska Samfundet. - 0560-2416. ; 76:Studier i svensk språkhistoria 13, s. 65-87, s. 65-87 Journal article (peer-reviewed)abstract Språkbanken, the Swedish Language Bank, is a language technology research unit at the Department of Swedish, University of Gothenburg. We develop language resources – such as corpora, lexical resources, and analytical tools – for all variants of Swedish, from Old Swedish laws to present-day social media. Historical texts offer exciting theoretical and methodological challenges for language technology because they often defy the assumption inherent in most automatic analysis tools that the texts contain a standardized written language. In this article, we describe our ongoing work on the development of annotated historical corpora, as well as our efforts on linking various resources (both corpora and lexical resources). This research advances the state of the art of language technology as well as enables new research for scholars in other disciplines.
32.	Alastalo, Ari, et al. (author) Printable WORM and FRAM memories and their applications 2010 In: Large area, organic & printed electronics (LOPE-C) 2010. - 9783000299551 ; , s. 8-12 Conference paper (peer-reviewed)
33.	Altenstedt, Johanna, et al. (author) Sensitivity Studies of the Chemical Scheme of the IVL Photochemical Trajectory Model 1996 Reports (other academic/artistic)abstract Sensitivity test of the updated chemical scheme of the IVL photochemical trajectory model have been performed for two chemical environments. The chemical description of the model has been investigated regarding the gas phase chemistry and the deposition
34.	Andersson, Annika, 1961- (author) Affärssystemsprojekt : konsekvenser av att vara sluten eller öppen för förändringar 2016 Doctoral thesis (other academic/artistic)abstract Affärssystemsprojekt är en väsentlig företeelse i organisationer. Allt ifrån små till större nationella och internationella företag har ett affärssystem som stöd för sina affärsprocesser. Införande och byte av affärssystem betraktas inom affärsvärlden som en av de mest krävande och riskfyllda förändringarna ett företag kan genomföra. Att studera affärssystemsprojekt är av intresse ur ett organisationsperspektiv eftersom resultatet får långvariga konsekvenser för organisationen. Interorganisatoriska affärssystemsprojekt består dessutom av parter från två organisationer, vilka har skilda typer av kompetenser och roller. I ett affärssystemsprojekt är begrepp som projektmål, tidsdimension, och interorganisatoriska team av vikt att diskutera. Kommunikation, funktionen som översättare mellan parterna och ledarnas delaktighet för att integrera informationsstrategier och affärsstrategier är, enligt tidigare forskning inom både informationssystems och projektforskning, av vikt att diskutera.Det finns olika synsätt på förändring och sambanden som råder vid genomförandet av affärssystemprojekt. Det ena är att projektdeltagarna bör vara slutna för förändring och det andra är att de bör vara öppna för förändring av projektmål, tid och team beroende på den kunskap som utvecklas. Studier som fokuserar på konsekvenser för organisationer av det ena eller andra synsättet är däremot begränsade. Studiens övergripande problem är att studera vilka konsekvenser det kan få för leverantörs respektive beställarorganisationerna om parterna är slutna respektive öppna för förändring.Avhandlingen avser att bidra till både näringsliv och affärssystemsforskningen genom att beskriva konsekvenser för leverantörs och beställarorganisationer av om parterna är slutna eller öppna för förändringar inom affärssystemsprojekt.Multipla och longitudinella fallstudier har genomförts för att uppmärksamma organisatoriska konsekvenser över tid. Studien har genomförts indelad i tre faser (1) en retrospektiv fas, (2) en observationsfas och (3) en longitudinell fas. Datainsamlingsmetoder som använts är intervjuer, observationer och dokumentgranskning för att beskriva konsekvenser för både leverantörs och beställarorganisationer som genomför affärssystemsprojekt.Resultaten visar att en öppenhet och en slutenhet för förändringar av projektmål, tid och team fick konsekvenser för de båda organisationerna. När båda parter var slutna för förändring blev det svårt att använda kunskap inom projekten. Leverantören identifierade strategiska lärandeprojekt innan de beslutade sig för att vara öppna för förändring. När beställarna var öppna för förändring och leverantören sluten för förändring genomförde beställarna lärande och förändringsprojekt utanför projekten och de gemensamma projekten sekventiellt. När båda parter var öppna för förändringar blev konsekvenserna varken system eller organisationsutveckling, vilket hade kunnat förväntas. Istället ledde det till kommunikationsbarriärer.I denna sammanläggningsavhandling sammanställs och beskrivs resultaten från studien av affärsystemsprojekt via fyra publicerade artiklar.
35.	Andersson, Bo, Docent, 1965-, et al. (author) Enhancing Information Quality as Part of the Disease Surveillance System in Malawi, Africa : Reflections on a mHealth Intervention 2017 In: Information Systems Development: Advances in Methods, Tools and Management. - Larnaca : Association for Information Systems. - 9789963228836 Conference paper (peer-reviewed)abstract Public health surveillance and response to disease outbreaks is still a hurdle in many developing countries across sub-Saharan Africa. Pivotal in disease surveillance and response is the reliance on valid information, hence, the need for information which has high Information Quality (IQ) characteristics. A key issue with disease surveillance systems, stem from the diverse range of data sources with various levels of information quality that may affect the trustworthiness of the information. However, with the increasing diffusion of mobile phone technologies, there are opportunities to improve IQ. The aim of this study was to assess the information quality in data collected through a smartphone application. Based on qualitative data from interviews, workshop and system specifications, it was found that information quality improves with the use of smartphone applications but aspects such as user competence and trustworthiness, must be addressed to maximize the benefits of using mobile technologies for disease surveillance.
36.	Andersson, Bo, et al. (author) Enhancing Information Quality as part of the disease surveillance system in Malawi, Africa: reflections on a mHealth intervention 2017 In: Proceedings of The 26th International Conference on Information Systems Development. Conference paper (peer-reviewed)
37.	Andersson, Carina, et al. (author) Design fixations among information design students : What has been seen cannot be unseen 2012 In: Proceedings of the 14th International Conference on Engineering and Product Design Education: Design Education for Future Wellbeing, EPDE 2012. - 9781904670360 ; , s. 159-166 Conference paper (peer-reviewed)abstract This research explores the phenomenon of design fixation by studying undergraduate design students undertaking an information product design problem. The research is based on a case study, with 64 students. The students were given a design problem, and their design processes were documented in a weblog, which was analyzed jointly with handouts and slide presentations. The research suggests that the formulation of ideas in and recording of an early group brainstorming sessions may contribute to fixation of the finale design solution.
38.	Andersson, Carina, 1970- (author) Informationsdesign i tillståndsövervakning : En studie av ett bildskärmsbaserat användargränssnitt för tillståndsövervakning och tillståndsbaserat underhåll 2010 Doctoral thesis (other academic/artistic)abstract This research concerns the information design and visual design of graphical user interfaces (GUI) in the condition monitoring and condition-based maintenance (CBM) of production equipment. It also concerns various communicative aspects of a GUI, which is used to monitor the condition of assets. It applies to one Swedish vendor and its intentions to design information. In addition, it applies to the interaction between the GUI and its individual visual elements, as well as the communication between the GUI and the users (in four Swedish paper mills).The research is performed as a single case study. Interviews and observations have been the main methods for data collection. Empirical data is analyzed with methods inferred to semiotics, rhetoric and narratology. Theories in information science and regarding remediation are used to interpret the user interface design.The key conclusion is that there are no less than five different forms of information, all important when determining the conditions of assets. These information forms include the words, images and shapes in the GUI, the machine components and peripherals equipment, the information that takes form when personnel communicate machine conditions, the personnel’s subjective associations, and the information forms that relate to the personnel's actions and interactions.Preventive technicians interpret the GUI-information individually and collectively in relation to these information forms, which influence their interpretation and understanding of the GUI information. Social media in the GUI makes it possible to represent essential information that takes form when employees communicate a machine’s condition. Photographs may represent information forms as a machine’s components, peripherals, and local environment change over time. Moreover, preventative technicians may use diagrams and photographs in the GUI to change attitudes among the personnel at the mills and convince them, for example, of a machine’s condition or the effectiveness of CBM as maintenance policy.
39.	Andersson, Christer, et al. (author) Manifest för lämplig styrning av hälso- och sjukvården 2018 In: Läkartidningen. - 0023-7205. ; 115:3 Journal article (peer-reviewed)
40.	Andersson, Ellinor, et al. (author) Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets. 2016 In: Modern Pathology. - : Elsevier BV. - 0893-3952 .- 1530-0285. ; 29:6, s. 616-629 Journal article (peer-reviewed)abstract We wanted to define the transcriptome of small intestinal neuroendocrine tumors in order to identify clinically relevant subgroups of tumors, prognostic markers and novel targets for treatment. Genome-wide expression profiling was conducted on tumor biopsies from 33 patients with well-differentiated neuroendocrine tumors of the distal ileum and metastatic disease at the time of diagnosis. Unsupervised hierarchical clustering analysis identified three groups of tumors. The largest group, comprising half of the tumors, was characterized by longer patient survival and higher expression of neuroendocrine markers, including SSTR2. Tumors with higher grade (G2/3) or gain of chromosome 14 were associated with shorter patient survival and increased expression of cell cycle-promoting genes. Pathway analysis predicted the prostaglandin E receptor 2 (PTGER2) as the most significantly activated regulator in tumors of higher grade, whereas Forkhead box M1 (FOXM1) was the most significantly activated regulator in tumors with gain of chromosome 14. Druggable genes identified from expression profiles included clinically proven SSTR2 and also novel targets, for example, receptor tyrosine kinases (RET, FGFR1/3, PDGFRB and FLT1), epigenetic regulators, molecular chaperones and signal transduction molecules. Evaluation of candidate drug targets on neuroendocrine tumors cells (GOT1) showed significant inhibition of tumor cell growth after treatment with tyrosine kinase inhibitors or inhibitors of HDAC, HSP90 and AKT. In conclusion, we have defined the transcriptome of small intestinal neuroendocrine tumors and identified novel subgroups with clinical relevance. We found specific gene expression patterns associated with tumor grade and chromosomal alterations. Our data also suggest novel prognostic biomarkers and therapies for these patients.
41.	Andersson, Gunvor, et al. (author) Om yngre barn i socialt arbete 2012 In: När samhället träder in : barn, föräldrar och social barnavård. - 9789144067445 ; , s. 91-117 Book chapter (peer-reviewed)
42.	Andersson, Gunvor, et al. (author) Social barnavård och barns utsatthet 2012. - 1 In: När samhället träder in. - Lund : Studentlitteratur. - 9789144067445 ; , s. 13-28 Book chapter (other academic/artistic)
43.	Andersson, Jan, et al. (author) Fisk- och skaldjursbestånd i hav och sötvatten 2015 : Resursöversikt 2015 Reports (other academic/artistic)abstract I rapporten kan du ta del av bedömningen som görs av situationen för bestånd som regleras inom ramen för EU:s gemensamma fiskeripolitik (GFP). Bedömningarna baseras på det forskningssamarbete och den rådgivning som sker inom det Internationella Havsforskningsrådet (ICES).De bestånd som förvaltas nationellt baseras på de biologiska underlagen och rådgivningen i huvudsak på den forskning och övervakning samt analys som bedrivs av Institutionen för akvatiska resurser (SLU Aqua) vid Sveriges lantbruksuniversitet (SLU) samt yrkesfiskets rapportering.Rapporten omfattar 40 fiskarter uppdelade i olika bestånd, samt sex skal-och blötdjursarter.Nytt för årets upplaga är en beskrivning av hur de provfisken som ligger till grund för analys och rådgivning utförs.Översikten är utarbetad av Sveriges lantbruksuniversitet (SLU), Institutionen för akvatiska resurser (SLU Aqua), på uppdrag av Havs- och vattenmyndigheten.
44.	Andersson, Kjell, et al. (author) Development of a harmonised method for the profiling of amphetamines : III. Development of the gas chromatographic method 2007 In: Forensic Science International. - : Elsevier. - 0379-0738 .- 1872-6283. ; 169:1, s. 50-63 Journal article (peer-reviewed)abstract This study focused on gas chromatographic analysis of target compounds found in illicit amphetamine synthesised by the Leuckart reaction, reductive amination of benzyl methyl ketone, and the nitrostyrene route. The analytical method was investigated and optimised with respect to introduction of amphetamine samples into the gas chromatograph and separation and detection of the target substances. Sample introduction using split and splitless injection was tested at different injector temperatures, and their ability to transfer the target compounds to the GC column was evaluated using cold on column injection as a reference. Taking the results from both techniques into consideration a temperature of 250 °C was considered to be the best compromise. The most efficient separation was achieved with a DB-35MS capillary column (35% diphenyl 65% dimethyl silicone; 30 m × 0.25 mm, df 0.25 μm) and an oven temperature program that started at 90 °C (1 min) and was increased by 8 °C/min to 300 °C (10 min). Reproducibility, repeatability, linearity, and limits of determination for the flame ionisation detector (FID), nitrogen phosphorous detector (NPD), and mass spectrometry (MS) in scan mode and selected ion monitoring (SIM) mode were evaluated. In addition, selectivity was studied applying FID and MS in both scan and SIM mode. It was found that reproducibility, repeatability, and limits of determination were similar for FID, NPD, and MS in scan mode. Moreover, the linearity was better when applying FID or NPD whereas the selectivity was better when utilising the MS. Finally, the introduction of target compounds to the GC column when applying injection volumes of 0.2 μl, 1 μl, 2 μl, and 4 μl with splitless injection respectively 1 μl with split injection (split ratio, 1:40) were compared. It was demonstrated that splitless injections of 1 μl, 2 μl, and 4 μl could be employed in the developed method, while split injection and splitless injections of 0.2 μl should be avoided.
45.	Andersson, Marlene, et al. (author) Carbonic Anhydrase Generates CO2 and H+ That Drive Spider Silk Formation Via Opposite Effects on the Terminal Domains 2014 In: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 12:8, s. e1001921- Journal article (peer-reviewed)abstract Spider silk fibers are produced from soluble proteins (spidroins) under ambient conditions in a complex but poorly understood process. Spidroins are highly repetitive in sequence but capped by nonrepetitive N- and C-terminal domains (NT and CT) that are suggested to regulate fiber conversion in similar manners. By using ion selective microelectrodes we found that the pH gradient in the silk gland is much broader than previously known. Surprisingly, the terminal domains respond in opposite ways when pH is decreased from 7 to 5: Urea denaturation and temperature stability assays show that NT dimers get significantly stabilized and then lock the spidroins into multimers, whereas CT on the other hand is destabilized and unfolds into ThT-positive beta-sheet amyloid fibrils, which can trigger fiber formation. There is a high carbon dioxide pressure (pCO(2)) in distal parts of the gland, and a CO2 analogue interacts with buried regions in CT as determined by nuclear magnetic resonance (NMR) spectroscopy. Activity staining of histological sections and inhibition experiments reveal that the pH gradient is created by carbonic anhydrase. Carbonic anhydrase activity emerges in the same region of the gland as the opposite effects on NT and CT stability occur. These synchronous events suggest a novel CO2 and proton-dependent lock and trigger mechanism of spider silk formation.
46.	Andersson, Mattias, et al. (author) Djupstabilisering i sulfidjord längs Botniabanan 2009 In: Samhällsbyggaren. - 2000-2408. ; :4, s. 48-52 Journal article (pop. science, debate, etc.)
47.	Andersson, Mattias K, 1979, et al. (author) Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling 2017 In: Jnci-Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 109:9 Journal article (peer-reviewed)abstract Background: Adenoid cystic carcinoma (ACC) is an aggressive cancer with no curative treatment for patients with recurrent/metastatic disease. The MYB-NFIB gene fusion is the main genomic hallmark and a potential therapeutic target. Methods: Oncogenic signaling pathways were studied in cultured cells and/or tumors from 15 ACC patients. Phospho-receptor tyrosine kinase (RTK) arrays were used to study the activity of RTKs. Effects of RTK inhibition on cell proliferation were analyzed with AlamarBlue, sphere assays, and two ACC xenograft models (n = 4-9 mice per group). The molecular effects of MYB-NFIB knockdown and IGF1R inhibition were studied with quantitative polymerase chain reaction, immunoblot, and gene expression microarrays. All statistical tests were two-sided. Results: The MYB-NFIB fusion drives proliferation of ACC cells and is crucial for spherogenesis. Intriguingly, the fusion is regulated through AKT-dependent signaling induced by IGF1R overexpression and is downregulated upon IGF1R-inhibition (% expression of control +/- SD = 27.2 +/- 1.3, P < .001). MYB-NFIB regulates genes involved in cell cycle control, DNA replication/repair, and RNA processing. The transcriptional program induced by MYB-NFIB affects critical oncogenic mediators normally controlled by MYC and is reversed by pharmacological inhibition of IGF1R. Co-activation of epidermal growth factor receptor (EGFR) and MET promoted proliferation of ACC cells, and combined targeting of IGFR1/EGFR/MET induced differentiation and synergistically inhibited the growth of patient-derived xenografted ACCs (ACCX5M1, % growth of control +/- SD = 34.9 +/- 20.3, P = .006; ACCX6, % growth of control +/- SD = 24.1 +/- 17.5, P = .04). Conclusions: MYB-NFIB is an oncogenic driver and a key therapeutic target in ACC that is regulated by AKT-dependent IGF1R signaling. Our studies uncover a new strategy to target an oncogenic transcriptional master regulator and provide new important insights into the biology and treatment of ACC.
48.	Andersson, Mattias K, 1979, et al. (author) The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response 2008 In: BMC Cell Biology. - : Springer Science and Business Media LLC. - 1471-2121. ; 9 Journal article (peer-reviewed)abstract BACKGROUND: FUS, EWS and TAF15 are structurally similar multifunctional proteins that were first discovered upon characterization of fusion oncogenes in human sarcomas and leukemias. The proteins belong to the FET (previously TET) family of RNA-binding proteins and are implicated in central cellular processes such as regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. In the present study, we investigated the expression and cellular localization of FET proteins in multiple human tissues and cell types. RESULTS: FUS, EWS and TAF15 were expressed in both distinct and overlapping patterns in human tissues. The three proteins showed almost ubiquitous nuclear expression and FUS and TAF15 were in addition present in the cytoplasm of most cell types. Cytoplasmic EWS was more rarely detected and seen mainly in secretory cell types. Furthermore, FET expression was downregulated in differentiating human embryonic stem cells, during induced differentiation of neuroblastoma cells and absent in terminally differentiated melanocytes and cardiac muscle cells. The FET proteins were targeted to stress granules induced by heat shock and oxidative stress and FUS required its RNA-binding domain for this translocation. Furthermore, FUS and TAF15 were detected in spreading initiation centers of adhering cells. CONCLUSION: Our results point to cell-specific expression patterns and functions of the FET proteins rather than the housekeeping roles inferred from earlier studies. The localization of FET proteins to stress granules suggests activities in translational regulation during stress conditions. Roles in central processes such as stress response, translational control and adhesion may explain the FET proteins frequent involvement in human cancer.
49.	Andersson, Mattias K, 1979, et al. (author) Tissue and cell specific expression patterns of the proto-oncogenic FUS, EWS and TAF15 ribonucleoproteins 2007 In: Molecular Targets for Cancer, Whistler Resort, Whistler, British Columbia, Canada. Conference paper (other academic/artistic)
50.	Andersson, Marlene, et al. (author) Morphology and Composition of the Spider Major Ampullate Gland and Dragline Silk 2013 In: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 14, s. 2945-2952 Journal article (peer-reviewed)abstract Spider silk is made of unique proteins-spidroins-secreted and stored as a protein solution (dope) in specialized glands. The major ampullate gland, source of the dragline silk, is composed of a tail, a sac and an elongated duct. For this gland, several different types of epithelial cells and granules have been described, but it is largely unknown how they correlate with spidroin production. It is also not settled what parts of the large spidroins end up in the final silk, and it has been suggested that the N-terminal domain (NT) is lacking. Here we show that NT is present in the dope and throughout drag,line silk fibers, including the skin layer, and that the major ampullate tail and sac consist of three different and sharply demarcated zones (A-C), each with a distinct epithelial cell type. Finally, we show that spidroins are produced in the A and B zone epithelia, while the C zone granules lack spidroins.

Skapa referenser, mejla, bekava och länka

Permalink

Träfflista för sökning "WFRF:(Andersson Yvonne) "

Refine your search

Year