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1.	Jacome, Cristina, et al. (författare) Feasibility and Acceptability of an Asthma App to Monitor Medication Adherence : Mixed Methods Study 2021 Ingår i: JMIR mhealth and uhealth. - : JMIR Publications. - 2291-5222. ; 9:5 Tidskriftsartikel (refereegranskat)abstract Background: Poor medication adherence is a major challenge in asthma, and objective assessment of inhaler adherence is needed. The InspirerMundi app aims to monitor adherence while providing a positive experience through gamification and social support. Objective: This study aimed to evaluate the feasibility and acceptability of the InspirerMundi app to monitor medication adherence in adolescents and adults with persistent asthma (treated with daily inhaled medication). Methods: A 1-month mixed method multicenter observational study was conducted in 26 secondary care centers from Portugal and Spain. During an initial face-to-face visit, physicians reported patients' asthma therapeutic plan in a structured questionnaire. During the visits, patients were invited to use the app daily to register their asthma medication intakes. A scheduled intake was considered taken when patients registered the intake (inhaler, blister, or other drug formulation) by using the image-based medication detection tool. At 1 month, patients were interviewed by phone, and app satisfaction was assessed on a 1 (low) to 5 (high) scale. Patients were also asked to point out the most and least preferred app features and make suggestions for future app improvements. Results: A total of 107 patients (median 27 [P25-P75 14-40] years) were invited, 92.5% (99/107) installed the app, and 73.8% (79/107) completed the 1-month interview. Patients interacted with the app a median of 9 (P25-P75 1-24) days. At least one medication was registered in the app by 78% (77/99) of patients. A total of 53% (52/99) of participants registered all prescribed inhalers, and 34% (34/99) registered the complete asthma therapeutic plan. Median medication adherence was 75% (P25-P75 25%-90%) for inhalers and 82% (P25-P75 50%-94%) for other drug formulations. Patients were globally satisfied with the app, with 75% (59/79) scoring >= 4,; adherence monitoring, symptom monitoring, and gamification features being the most highly scored components; and the medication detection tool among the lowest scored. A total of 53% (42/79) of the patients stated that the app had motivated them to improve adherence to inhaled medication and 77% (61/79) would recommend the app to other patients. Patient feedback was reflected in 4 major themes: medication-related features (67/79, 85%), gamification and social network (33/79, 42%), symptom monitoring and physician communication (21/79, 27%), and other aspects (16/79, 20%). Conclusions: The InspirerMundi app was feasible and acceptable to monitor medication adherence in patients with asthma. Based on patient feedback and to increase the registering of medications, the therapeutic plan registration and medication detection tool were redesigned. Our results highlight the importance of patient participation to produce a patient-centered and engaging mHealth asthma app.
2.	Jacome, Cristina, et al. (författare) Monitoring Adherence to Asthma Inhalers Using the InspirerMundi App : Analysis of Real-World, Medium-Term Feasibility Studies 2021 Ingår i: Frontiers in Medical Technology. - : Frontiers Media S.A.. - 2673-3129. ; 3 Tidskriftsartikel (refereegranskat)abstract Background: Poor medication adherence is a major challenge in asthma and objective assessment of inhaler adherence is needed. InspirerMundi app aims to monitor inhaler adherence while turning it into a positive experience through gamification and social support.Objective: We assessed the medium-term feasibility of the InspirerMundi app to monitor inhaler adherence in real-world patients with persistent asthma (treated with daily inhaled medication). In addition, we attempted to identify the characteristics of the patients related to higher app use.Methods: Two real-world multicenter observational studies, with one initial face-to-face visit and a 4-month telephone interview, were conducted in 29 secondary care centers from Portugal. During an initial face-to-face visit, patients were invited to use the app daily to register their asthma medication intakes. A scheduled intake was considered taken when patients took a photo of the medication (inhaler, blister, or others) using the image-based medication detection tool. Medication adherence was calculated as the number of doses taken as a percentage of the number scheduled. Interacting with the app =30 days was used as the cut-off for higher app use.Results: A total of 114 patients {median 20 [percentile 25 to percentile 75 (P25-P75) 16-36] years, 62% adults} were invited, 107 (94%) installed the app and 83 (73%) completed the 4-month interview. Patients interacted with the app for a median of 18 [3-45] days, translated on a median use rate of 15 [3-38]%. Median inhaler adherence assessed through the app was 34 [4-73]% when considering all scheduled inhalations for the study period. Inhaler adherence assessed was not significantly correlated with self-reported estimates. Median adherence for oral and other medication was 41 [6-83]% and 43 [3-73]%, respectively. Patients with higher app use were slightly older (p = 0.012), more frequently taking medication for other health conditions (p = 0.040), and more frequently prescribed long-acting muscarinic antagonists (LAMA, p = 0.024). After 4 months, Control of Allergic Rhinitis and Asthma Test (CARAT) scores improved (p < 0.001), but no differences between patients interacting with the app for 30 days or less were seen.Conclusions: The InspirerMundi app was feasible to monitor inhaler adherence in patients with persistent asthma. The persistent use of this mHealth technology varies widely. A better understanding of characteristics related to higher app use is still needed before effectiveness studies are undertaken.
3.	Carvalho, Joao, et al. (författare) A drill-hole, geological and geophysical data-based 3D model for target generation in Neves-Corvo mine region, Portugal 2022 Ingår i: International journal of earth sciences. - : Springer Nature. - 1437-3254 .- 1437-3262. ; 111, s. 403-424 Tidskriftsartikel (refereegranskat)abstract The Neves-Corvo world class Iberian Pyrite Belt volcanogenic massive sulphide (VMS) deposit located in southern Portugal, constitutes an important Cu-Zn-Pb active mine. Seven deposits are currently known, among which the Lombador deposit alone has estimated 150 Mt of massive sulphides. The life-time of the mine is dependent on the discovery of new exploration targets and it is vital to have accurate 3D geological models, not only to guide drilling campaigns but also to drive a winning/new strategy, which in the past has led to Semblana and Monte Branco discoveries: geophysical inversion and modelling. Furthermore, 3D geological models can contribute to the understanding of the tectonic and stratigraphic evolution of the region. Therefore, the goal of this study is to produce a realistic 3D geological model of the Neves-Corvo region, as only one model is presently publicly available: the PROMINE model, which includes the study area of this work and extends from Aljustrel to the border with Spain. Lundin Mining has also produced two unpublished, confidential models in 2007 and 2017. The latest Lundin model incorporates the same geophysical data used in this work (2D and 3D seismic reflection and time-domain electromagnetic (TEM) ground loop data) and approximately 7500 surface and underground drill-holes. The model presented in this research has much more detail than the 2012 PROMINE model in the Neves-Corvo region and uses an updated and revised drill-hole database with approximately 8000 drill-holes, revised geological cross-sections built from surface geology and drill-hole logs, new geological outcrop data, petrophysical and reprocessed geophysical data, and is therefore more detailed and accurate than any of the previous models, in particular the 2007 and PROMINE models. Land gravimetric and aeromagnetic data are also available in the study area but were not directly used to build the geological model but rather to investigate and check the model produced. Modelling was performed with industry standard software and the 3D curves resulting from the geological/geophysical interpretation were interpolated using different approaches to respect the hard data (interpretation lines and drill-holes). The resulting 3D stratigraphic surfaces required strong manual editing to respect the interpretation, due to the presence of folds, thrusts and tectonic nappes in the study area. The surfaces were afterwards tied to the drill-holes, resulting in a 3D model with great accuracy and detail in the near mining area and covering a larger area than previously available 3D geological models. The model has three major stratigraphic layers: the Mertola Flysch Formation and the Volcano-Sedimentary Complex (VSC), overlying the Phyllite-Quartzite Formation basement, and also the known VMS deposits (underlying the top of the Lower VSC) geometries according to drill-hole data. In the central part of the study area, where more drill-holes are available, the top of the Lower VSC sequence surface was also built. This approach will contribute to a better exploration drill-hole planning and the generation of new targets for exploration.
4.	Marto, João Pedro, et al. (författare) Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry. 2023 Ingår i: Neurology. - 1526-632X. ; 100:7 Tidskriftsartikel (refereegranskat)abstract COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT).Of a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour mortality (OR 2.47; 95% CI 1.58-3.86), and 3-month mortality (OR 1.88; 95% CI 1.52-2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60).Patients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring, and establishing prognosis.The study was registered under ClinicalTrials.gov identifier NCT04895462.
5.	Amaral, Rita, et al. (författare) Profiling Persistent Asthma Phenotypes in Adolescents : A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies 2021 Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 18:3 Tidskriftsartikel (refereegranskat)abstract We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.
6.	Ramos Do Prado, Samira B., et al. (författare) Physiological Degradation of Pectin in Papaya Cell Walls : Release of Long Chains Galacturonans Derived from Insoluble Fractions during Postharvest Fruit Ripening 2016 Ingår i: Frontiers in Plant Science. - : Frontiers Media S.A.. - 1664-462X. ; 7 Tidskriftsartikel (refereegranskat)abstract Papaya (Carica papaya L.) is a fleshy fruit that presents a rapid pulp softening during ripening. However, the timeline on how papaya pectinases act in polysaccharide solubilization and the consequent modification of the cell wall fractions during ripening is still not clear. In this work, the gene expression correlations between, on one hand, 16 enzymes potentially acting during papaya cell wall disassembling and, on the other hand, the monosaccharide composition of cell wall fractions during papaya ripening were evaluated. In order to explain differences in the ripening of papaya samplings, the molecular mass distribution of polysaccharides from water-soluble and oxalate-soluble fractions (WSF and OSF, respectively), as well as the oligosaccharide profiling from the WSF fraction, were evaluated by high performance size exclusion chromatography coupled to a refractive index detector and high performance anion-exchange chromatography coupled to pulse amperometric detection analyses, respectively. Results showed that up-regulated polygalacturonase and β-galactosidase genes were positively correlated with some monosaccharide profiles. In addition, an overall increase in the retention time of high molecular weight (HMW) and low molecular weight (LMW) polysaccharides in WSF and OSF was shown. The apparent disappearance of one HMW peak of the OSF may result from the conversion of pectin that were crosslinked with calcium into more soluble forms through the action of PGs, which would increase the solubilization of polysaccharides by lowering their molecular weight. Thus, the results allowed us to propose a detailed process of papaya cell wall disassembling that would affect sensorial properties and post-harvesting losses of this commercially important fruit.
7.	Scalon, Lucas, et al. (författare) Assessing the Donor-Acceptor Nature and the Electrochemical Stability of a Fluorene-Diketopyrrolopyrrole-Thiophene-Based Copolymer 2021 Ingår i: ACS Applied Polymer Materials. - : American Chemical Society (ACS). - 2637-6105. ; 3:8, s. 4223-4233 Tidskriftsartikel (refereegranskat)abstract Organic dyes have been studied for applications in large-area, flexible, cheap, and efficient organic electronic devices. Among them, diketopyrrolopyrrole (DPP) has gained attention thanks to its planar structure, photochemical and thermal stability, and easy processability. Also, the electron-withdrawing nature of DPP makes its application attractive in the synthesis of donor-acceptor (D-A) copolymers, with appealing features such as the tunable energy levels and photophysical and electrochemical properties. Inspired by these exciting characteristics, a copolymer was developed based on DPP, thiophene, and fluorene (PFDPP2T). Photophysical and electrochemical studies using both experimental and theoretical approaches were performed aiming to understand the properties of this material, such as, for instance, the D-A characteristic and the outstanding electrochemical stability upon oxidation that enables more than 400 cycles of p-doping. The outcomes unveil fundamental aspects of this class of copolymers, reinforcing their suitability for photo-electrochemical and optoelectronic applications.
8.	Araújo, Inês, et al. (författare) Proteolysis of NR2B by calpain in the hippocampus of epileptic rats. 2005 Ingår i: NeuroReport. - 1473-558X. ; 16:4, s. 393-396 Tidskriftsartikel (refereegranskat)
9.	Araujo, Jefferson, et al. (författare) Characterizing complex mineral structures in thin sections of geological samples with a scanning hall effect microscope 2019 Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 19:7 Tidskriftsartikel (refereegranskat)abstract We improved a magnetic scanning microscope for measuring the magnetic properties of minerals in thin sections of geological samples at submillimeter scales. The microscope is comprised of a 200 µm diameter Hall sensor that is located at a distance of 142 µm from the sample; an electromagnet capable of applying up to 500 mT DC magnetic fields to the sample over a 40 mm diameter region; a second Hall sensor arranged in a gradiometric configuration to cancel the background signal applied by the electromagnet and reduce the overall noise in the system; a custom-designed electronics system to bias the sensors and allow adjustments to the background signal cancelation; and a scanning XY stage with micrometer resolution. Our system achieves a spatial resolution of 200 µm with a noise at 6.0 Hz of 300 nT rms /(Hz) 1/2 in an unshielded environment. The magnetic moment sensitivity is 1.3 × 10 −11 Am 2 . We successfully measured the representative magnetization of a geological sample using an alternative model that takes the sample geometry into account and identified different micrometric characteristics in the sample slice.
10.	Araújo, José, et al. (författare) Self-triggered control for industrial wireless sensor and actuator networks 2011 Konferensbidrag (refereegranskat)abstract Energy and communication bandwidth are scarceresources in wireless sensor and actuator networks. Recentresearch efforts considered the control of physical processes oversuch resource limited networks. Most of the existing literatureaddressing this topic is dedicated to periodically sampled controlloops and scheduled communication, because it simplifies theanalysis and the implementation. We propose instead an aperiodicnetwork transmission scheme that reduces the number oftransmission instances for the sensor and control nodes, therebyreducing energy consumption and increasing network lifetime,without sacrificing control performance. As an added benefit,we show the possibility of dynamically allocating the networkbandwidth based on the physical system state and the availableresources. In order to allow timely, reliable, and energy efficientcommunication, we propose a new co-design framework forthe wireless medium access control, compatible with the IEEE802.15.4 standard. Furthermore, we validate our approach in areal wireless networked control implementation.
11.	Araujo, L. F., et al. (författare) In-fiber optofluidic alignment of Au-nanorods 2017 Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. ; , s. 132-133 Konferensbidrag (refereegranskat)abstract Optofluidic all-fiber devices are used for orientation of Au-nanorods under strongelectric fields. The dynamics is studied on sub-microsecond time-scales. A two-level laser rateequation model allows inferring diffusion rate, rotational mobility and other parameters.
12.	Araujo, Leonardo F., et al. (författare) Photonics with special optical fibers and nanoparticles 2016 Ingår i: Optics InfoBase Conference Papers. - 9781943580163 Konferensbidrag (refereegranskat)abstract Optical properties of nanorods in the presence of external electric field when confined to a special optical fiber was investigated, showing an increase of the longitudinal absorption peak in the presence of the field.
13.	Araújo, Marco, 1982-, et al. (författare) A Multi-Criteria Approach to Decision Making in Broadband Technology Selection 2022 Ingår i: Group Decision and Negotiation. - : Springer Science and Business Media LLC. - 0926-2644 .- 1572-9907. ; 31:2, s. 387-418 Tidskriftsartikel (refereegranskat)abstract A new European Union regulatory framework for the telecom sector has been under a process of transposition to national laws by its member states that should have been completed by the end of 2020, notwithstanding some delays. A core purpose of the regulatory framework is to guarantee that most citizens will have access to very fast Internet connections, capable of 100 Mbps download link speed, regardless of where they live. According to this new framework, in areas where the market does not deliver, governments are to launch public tenders for the deployment, maintenance, and operations of network infrastructure as well as services, and public funds should be used to support the deployment of these broadband networks in less densely populated areas. Needless to say, public tenders of this nature are subject to different criteria when it comes to candidate evaluation. In this paper, we present a decision model for the selection of operators to deploy and maintain broadband networks in scarcely populated areas, taking into consideration infrastructure costs, the technical quality offered by the solutions, and the credibility of the candidates. We suggest an integrated multi-stakeholder multi-criteria approach and demonstrate how it can be used in this complex area and find that in the example provided, taking a relevant set of criteria into the analysis, optical fibre networks hold much higher chances to be used in these public tenders compared to networks based on the broadly favoured 5G technology.
14.	Araújo, Marco, et al. (författare) A real options approach to decision making in broadband technology selection 2019 Ingår i: International Journal of Multicriteria Decision Making. - 2040-106X .- 2040-1078. ; 8:2, s. 184-210 Tidskriftsartikel (refereegranskat)abstract The European Union has recently launched an ambitious plan to mitigate drastically, by 2025, the number of households lacking access to a 100 Mbps broadband connection through the subsidisation of the deployment of network infrastructure in rural areas. Decision makers such as governments and regulatory authorities therefore have to choose, among a pool of alternatives, a technology capable of delivering the required throughput on a large scale, based on a trade-off between the infrastructure costs and the subscribers’ perceived utility for each alternative. Such a trade-off is not simple, since there is no straightforward manner to rank the subscribers’ perceived utility against the network infrastructure cost. In this article, we propose a methodology based on real options, which outputs the value of each technology using multi-attribute value theory as an input, alongside the project’s risk and its costs.
15.	Araújo, Marco, et al. (författare) A Utility Based Price Model for High Capacity Rural Networks in the European Union 2018 Ingår i: 2018 IEEE 29th Annual International Symposium on Personal, Indoor and Mobile Radio Communications (PIMRC). - : IEEE. - 9781538660102 - 9781538660096 ; , s. 253-258 Konferensbidrag (refereegranskat)abstract The European Union has been battling against the digital divide for several decades now when trying to mitigate the risk of social exclusion arising from the lack of broadband access, preventing citizens from full social and economic participation in the society. This has been done in the past by ensuring that a minimum set of services would be available to all end-users at an affordable price. However, various aspects of the rapid advances in technology, market developments and changes in user demand as well as the evolution of the telecommunications infrastructure (5G, IoT, Cloud, gigabit access, etc) increase the risk that citizens of rural areas are facing a severe risk of digital exclusion. To avoid this risk, the concept of subsidised rural networks was created by the European Commission. The idea as such is laudable, but the price tag remains unknown, which severely violates its implementability. In this article, based on the actual cost in a subsidised, but competitive, environment, we suggest a novel approach to realistically determine fair end-user's prices.
16.	Araújo, Marco, 1982- (författare) Infrastructure deployment in unprofitable areas : A techno-economic model for multiple criteria decision analysis under the European Union telecommunications regulatory framework 2020 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract In the European Union significant asymmetries prevail among member states in the most diverse areas. The telecom sector is no exception to this, with some members being much more advanced than others. Within the member states asymmetries also occur. And if we extrapolate this to a broader audience, for example the OECD, the European Union has been far away from some other members in what concerns asymmetries within own countries, with Japan and South Korea being the most evident. In 2016 the European Commission proposed a new regulatory framework for the telecom sector which was adopted in late 2018 by the European Parliament and must be transposed to national laws by member-states by late 2020. As we move towards the digital revolution, the so-called industry 4.0, the new EU regulatory framework has the aim of removing most of these asymmetries, by guaranteeing that most citizens will have access to a very fast Internet connection regardless of where they live. This regulatory framework provides some guidance and goals and funding objectives, but for operators and governments this is just not sufficient per se. Against this background, the overall research issue of this thesis is a methodological approach to how to determine the best access technology from a multi-criteria and multi-stakeholder perspective. In particular, to provide coverage in a certain region who lacks service a priori (therefore unprofitable by nature), problematics to be addressed include: i) what are exactly the new regulatory framework guidelines; ii) which strategic operational model to use; iii) what is the most appropriate technology to achieve these objectives; iv) how to handle the pricing incognita and all the financial component; v) how risky it is to make these objectives a reality.
17.	Araújo, Marco, et al. (författare) Risk assessment in 5G infrastructure deployment : an aid tool for estimating spectrum auction prices 2019 Ingår i: 2019 IEEE Wireless Communications and Networking Conference Workshop (WCNCW). - : IEEE. - 9781728109237 - 9781728109220 Konferensbidrag (refereegranskat)abstract Risks are significant when implementing large-scale projects such as 5G. The higher the overall risk of the 5G project, the lower the operators’ willingness to invest in millimetre wave spectrum and vice-versa; i.e. the price of the spectrum should be negatively correlated with the overall project risk. In this paper, we propose an array-based method for estimating financial risks when introducing 5G and its correspondence with spectrum prices. The method is based on Monte Carlo simulations, for deriving an appropriate maximum value for the operator’ willingness to pay for a 5G license.
18.	Araújo, Marco, et al. (författare) Rural Networks Cost Comparison Between 5G (Mobile) and FTTx (Fixed) Scenarios 2018 Ingår i: 2018 IEEE 29th Annual International Symposium on Personal, Indoor and Mobile Radio Communications (PIMRC). - : IEEE. - 9781538660102 - 9781538660096 ; , s. 259-264 Konferensbidrag (refereegranskat)abstract In this article we simulate the infrastructure costs for very fast networks in rural areas. FTTH technology has been around for at least a decade, but two brand new technologies are expected to launch commercially in the next couple of years: 5G and G. Fast. This could have a strong impact on infrastructure costs and the fulfilment of the European Union, rural coverage objectives. 5G seems to be very promising since LTE is not a reasonable solution for very fast networks. FTTC has so far not been a valid alternative, since for the last mile, the only options for FTTC has been ADSL and VDSL, which however cannot reach very fast data rates. G.Fast is three times faster than VDSL and has the advantage, comparing to FTTH, that the last mile infrastructure is already build in the form of copper local loop.
19.	Araújo, Marco, et al. (författare) Satellite backhaul for macro-cells, as an alternative to optical fibre, to close the digital divide 2019 Ingår i: 2019 IEEE Wireless Communications and Networking Conference (WCNC). - : IEEE. - 9781538676479 - 9781538676462 Konferensbidrag (refereegranskat)abstract The lack of broadband access causes a serious risk of social exclusion, by preventing citizens from full social and economic participation in the society. To avoid this risk, the concept of subsidized rural networks was developed by the European Commission, in which an operator builds, maintains and operates a network (usually an open network) capable of providing at least a 100 Mbps connection to the subscribers; deployed in low density regions being publicly subsidized when unprofitable. In this article, we suggest a methodology to measure a realistic value for the average broadband used per subscriber at busy hour. We also present a simulation model for the backhaul infrastructure costs for very fast networks in rural areas to cover the last, and more expensive, 5% of the population, while comparing optical fibre with satellite for the middle mile from an economical and financial perspective.
20.	Ayala, Alba, et al. (författare) Influence of Active and Healthy Ageing on Quality of Life Changes : Insights from the Comparison of Three European Countries 2021 Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 18:8 Tidskriftsartikel (refereegranskat)abstract This study aimed to analyze the determinants of quality of life (QoL) in older people in three European countries (Portugal, Spain and Sweden). A sample of 7589 participants in waves 4 (2011) and 6 (2015) of the Survey on Health, Aging, and Retirement in Europe (SHARE) project, aged 50 and over and living in Portugal, Spain and Sweden, was included. The CASP-12 scale was used to measure QoL. A principal component analysis was performed to group preselected variables related to active and healthy ageing into the dimensions of health, social participation, and lifelong learning. A linear regression model was built using the change in CASP-12 scores over the 4-year follow-up as the dependent variable, including the interactions between country and each independent variable in the model. After four years, the average QoL increased in Portugal (difference = 0.8, p < 0.001), decreased in Spain (-0.8, p < 0.001), and remained constant in Sweden (0.1, p = 0.408). A significant country-participation component interaction (p = 0.039) was found. In Spain, a higher participation (beta = 0.031, p = 0.002) was related to a higher QoL improvement at 4 years, but not in Sweden or Portugal. Physical health and emotional components (beta = 0.099, p < 0.001), functional ability (beta = 0.044, p = 0.023), and cognitive and sensory ability (beta = 0.021, p = 0.026) were associated with QoL changes over time in all countries. The country-specific associations between health, social participation and QoL should be taken into account when developing public health policies to promote QoL among European older people.
21.	Bancroft, EK, et al. (författare) Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: results from the initial screening round of the IMPACT study 2014 Ingår i: European urology. - : Elsevier BV. - 1873-7560 .- 0302-2838. ; 66:3, s. 489-499 Tidskriftsartikel (refereegranskat)
22.	Bettencourt-Silva, Rita, et al. (författare) Diabetes-related symptoms, acute complications and management of diabetes mellitus of patients who are receiving palliative care : a protocol for a systematic review 2019 Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 9:6 Forskningsöversikt (refereegranskat)abstract Introduction: Worldwide, an estimated 40 million people are in need of palliative care each year, but only 14% receive it. The incidence of diabetes mellitus (DM) in patients receiving palliative care is higher than in the general population. This association is intended to grow as a result of the rising burden of DM worldwide, ageing populations and the improved overall survival time of several diseases over the last few decades. Recommendations for DM management in the context of palliative care are mainly based on expert opinion as there is a lack of suitable evidence base and randomised clinical trials in palliative care are scarce. The aim of our systematic review is to identify the best DM management practices in order to reduce important DM-related symptoms and acute complications in patients receiving palliative care.Methods and analysis: The authors will study the DM treatment and management literature, surveying the different approaches employed to treat adult palliative patients. Core health bibliographic databases will be searched from January 1990 to May 2019. Data sources will include Ovid MEDLINE, Embase, PubMed, Web of Sciences, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Scopus, Cumulative Index to Nursing and Allied Health Literature and grey literature. Details regarding diet, oral and injectable glucose-lowering medicines, insulin regimens and blood glucose monitoring strategies will he evaluated. We defined the primary outcomes to compare between DM management approaches as the presence of symptoms (polyuria, polydipsia and polyphagia) and acute complications of DM (hypoglycaemia, hyperglycaemic hyperosmolar state and diabetic ketoacidosis), and secondary outcomes as hospital admissions and deaths due to DM-related complications, health-related quality of life and glycaemic control.Ethics and dissemination: The systematic review methodology does not require ethics approval due to the nature of the study design. The results of the systematic review will be published in a peer-reviewed journal and will he publicly available.PROSPERO registration number: CRD42018115772.
23.	Blomström-Lundqvist, Carina, et al. (författare) ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary : a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias). 2003 Ingår i: Circulation. - 1524-4539. ; 108:15, s. 1871-909 Tidskriftsartikel (refereegranskat)
24.	Blomström-Lundqvist, Carina, et al. (författare) ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary. a report of the American college of cardiology/American heart association task force on practice guidelines and the European society of cardiology committee for practice guidelines (writing committee to develop guidelines for the management of patients with supraventricular arrhythmias) developed in collaboration with NASPE-Heart Rhythm Society. 2003 Ingår i: J Am Coll Cardiol. - 0735-1097. ; 42:8, s. 1493-531 Tidskriftsartikel (refereegranskat)
25.	Brilhante, Raimunda Sâmia Nogueira, et al. (författare) Antifungal Activity of Chitosan against Histoplasma capsulatum in Planktonic and Biofilm Forms : A Therapeutic Strategy in the Future? 2023 Ingår i: Journal of Fungi. - : MDPI AG. - 2309-608X. ; 9:12 Tidskriftsartikel (refereegranskat)abstract Histoplasmosis is a respiratory disease caused by Histoplasma capsulatum, a dimorphic fungus, with high mortality and morbidity rates, especially in immunocompromised patients. Considering the small existing therapeutic arsenal, new treatment approaches are still required. Chitosan, a linear polysaccharide obtained from partial chitin deacetylation, has anti-inflammatory, antimicrobial, biocompatibility, biodegradability, and non-toxicity properties. Chitosan with different deacetylation degrees and molecular weights has been explored as a potential agent against fungal pathogens. In this study, the chitosan antifungal activity against H. capsulatum was evaluated using the broth microdilution assay, obtaining minimum inhibitory concentrations (MIC) ranging from 32 to 128 µg/mL in the filamentous phase and 8 to 64 µg/mL in the yeast phase. Chitosan combined with classical antifungal drugs showed a synergic effect, reducing chitosan’s MICs by 32 times, demonstrating that there were no antagonistic interactions relating to any of the strains tested. A synergism between chitosan and amphotericin B or itraconazole was detected in the yeast-like form for all strains tested. For H. capsulatum biofilms, chitosan reduced biomass and metabolic activity by about 40% at 512 µg/mL. In conclusion, studying chitosan as a therapeutic strategy against Histoplasma capsulatum is promising, mainly considering its numerous possible applications, including its combination with other compounds.
26.	Brodic, Bojan, et al. (författare) Innovative seismic imaging of volcanogenic massive sulfide deposits, Neves-Corvo, Portugal - Part 1 : In-mine array 2021 Ingår i: Geophysics. - : Society of Exploration Geophysicists. - 0016-8033 .- 1942-2156. ; 86:3, s. B165-B179 Tidskriftsartikel (refereegranskat)abstract To evaluate and upscale the feasibility of using exploration tunnels in an operating mine for active-source seismic imaging, a seismic experiment was conducted at the Neves-Corvo mine, in southern Portugal. Four seismic profiles were deployed in exploration drifts approximately 650 m beneath the ground surface, above the world-class Lombador volcanogenic massive sulfide deposit. In addition to the tunnel profiles, two perpendicular surface seismic profiles were deployed above the exploration tunnels. The survey was possible due to a newly developed prototype global positioning system (GPS) time transmitter enabling accurate GPS synchronization of cabled and nodal seismic recorders, below and on the surface. Another innovative acquisition aspect was a 1.65 t broadband, linear synchronous motor (LSM) driven - electric seismic vibrator (e-vib) used as the seismic source along two of the exploration tunnels. We have evaluated the challenges and innovations necessary for active-source tunnel seismic acquisition, characterized by high levels of vibrational noise from the mining activities. In addition, we evaluated the LSM vibrator's signal and overall seismic-data quality in this hard rock mining environment. Our processing results from the tunnel data and 3D reflection imaging of the Lombador deposit below the exploration tunnels were checked for consistency through constant-velocity 3D ray-tracing traveltime forward modeling. For imaging purposes, 3D Kirchhoff prestack depth and poststack time-migration algorithms were used, with both successfully imaging the targeted deposit. The results obtained show that active-source-seismic imaging using subsurface mining infrastructure of operational mines is possible. However, it requires innovative exploration strategies, a broadband seismic source, an accurate GPS-time system capable of transmitting GPS-time hundreds of meters below the surface, and careful processing. The results obtained open up possibilities for similar studies in different mining or tunneling projects.
27.	Capela, Joao Paulo, et al. (författare) The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons 2013 Ingår i: NeuroToxicology. - : Elsevier BV. - 1872-9711 .- 0161-813X. ; 34, s. 254-263 Tidskriftsartikel (refereegranskat)abstract 3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") and 2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) are hallucinogenic amphetamines with addictive properties. The hippocampus is involved in learning and memory and seems particularly vulnerable to amphetamine's neurotoxicity. We evaluated the neurotoxicity of DOI and MDMA in primary neuronal cultures of hippocampus obtained from Wistar rat embryos (E-17 to E-19). Mature neurons after 10 days in culture were exposed for 24 or 48 h either to MDMA (100-800 mu M) or DOI (10-100 mu M). Both the lactate dehydrogenase (LDH) release and the tetrazolium-based (MTT) assays revealed a concentration- and time-dependent neuronal death and mitochondrial dysfunction after exposure to both drugs. Both drugs promoted a significant increase in caspase-8 and caspase-3 activities. At concentrations that produced similar levels of neuronal death, DOI promoted a higher increase in the activity of both caspases than MDMA. In the mitochondrial fraction of neurons exposed 24 h to DOI or MDMA, we found a significant increase in the 67 kDa band of apoptosis inducing factor (AIF) by Western blot. Moreover, 24 h exposure to DOI promoted an increase in cytochrome c in the cytoplasmatic fraction of neurons. Pre-treatment with an antibody raised against the 5-HT2A-receptor (an irreversible antagonist) greatly attenuated neuronal death promoted by 48 h exposure to DOI or MDMA. In conclusion, hallucinogenic amphetamines promoted programmed neuronal death involving both the mitochondria machinery and the extrinsic cell death key regulators. Death was dependent, at least in part, on the stimulation of the 5-HT2A-receptors. (C) 2012 Elsevier Inc. All rights reserved.
28.	Costa, Joao, et al. (författare) The burden of atherosclerosis in Portugal 2021 Ingår i: European Heart Journal - Quality of Care and Clinical Outcomes. - : Oxford University Press. - 2058-5225 .- 2058-1742. ; 7:2, s. 154-162 Tidskriftsartikel (refereegranskat)abstract Aims This article sought to estimate the burden of disease attributable to atherosclerosis in mainland Portugal in 2016.Methods and results The burden of atherosclerosis was measured in disability-adjusted life years following the latest 2010 Global Burden of Disease (GBD) methodology. Disability-adjusted life years were estimated as the sum of years of life lost (YLL) with years lived with disability (YLD). The following clinical manifestations of atherosclerosis were included: ischaemic heart disease (IHD) (including acute myocardial infarction, stable angina, and ischaemic heart failure), ischaemic cerebrovascular disease (ICVD), and peripheral arterial disease (PAD). Years of life lost were estimated based on all-cause mortality data for the Portuguese population and mortality due to IHD, ICVD, and PAD for the year 2016 sourced from national statistics. Standard life expectancy was sourced from the GBD study. Years lived with disability corresponded to the product of the number of prevalent cases by an average disability weight for all possible combinations of disease. Prevalence data for the different clinical manifestations of atherosclerosis were sourced from epidemiological studies. Disability weights were sourced from the published literature. In 2016, 15123 deaths were attributable to atherosclerosis, which corresponded to 14.3% of overall mortality in mainland Portugal. Disability-adjusted life years totalled 260943, 75% due to premature death (196438 YLL) and 25% due to disability (64505 YLD).Conclusion Atherosclerosis entails a high disease burden to society. A large part of this burden would be avoidable if evidence-based effective and cost-effective interventions targeting known risk factors, from prevention to treatment, were implemented.
29.	da S. Ramos, Alessandro, et al. (författare) Comparative assessment between different sample preparation methodologies for PTGA CO2 adsorption assays—Pellet, powder, and fragment samples 2018 Ingår i: Adsorption Science and Technology. - : Sage Publications. - 0263-6174 .- 2048-4038. ; 36:7-8, s. 1441-1455 Tidskriftsartikel (refereegranskat)abstract The carbon dioxide sorption process at coal seams is very important for understanding the trapping mechanisms of carbon capture and storage. The gas retention capacity of coal seams can be estimated using indirect methods based on the adsorption/desorption isotherms obtained in the laboratory. However, the gas sorption capacity can be overestimated or underestimated depending on the sample preparation. This work evaluates different sample preparations and their theoretical adsorption capacity using coal samples from the Cambui coal field (Parana Basin), southern Brazil. Experiments using a thermogravimetric balance were done to calculate the theoretical adsorption capacity, while sample characterization was done through immediate analysis, elementary analysis, and mineralogical studies. The sample preparations used in this work were powder, pellets, and fragments. While the powder form presents an average behavior, without any experimental complication, the pellet is extremely sensitive to any variation in the sample preparation, such as fractures, and the fragment requires a much longer experiment time than the other sample preparations, being impracticable for some cases.
30.	da Silva, Leandro João, et al. (författare) Concept and validation of an active cooling technique to mitigate heat accumulation in WAAM 2020 Ingår i: The International Journal of Advanced Manufacturing Technology. - : Springer Science and Business Media LLC. - 0268-3768 .- 1433-3015. ; 107:5-6, s. 2513-2523 Tidskriftsartikel (refereegranskat)abstract This work aimed at introducing and exploring the potential of a thermal management technique, named as near-immersion active cooling (NIAC), to mitigate heat accumulation in Wire + Arc Additive Manufacturing (WAAM). According to this technique concept, the preform is deposited inside a work tank that is filled with water, whose level rises while the metal layers are deposited. For validation of the NIAC technique, Al5Mg single-pass multi-layer linear walls were deposited by the CMT® process under different thermal management approaches. During depositions, the temperature history of the preforms was measured. Porosity was assessed as a means of analyzing the potential negative effect of the water cooling in the NIAC technique. The preform geometry and mechanical properties were also assessed. The results showed that the NIAC technique was efficient to mitigate heat accumulation in WAAM of aluminum. The temperature of the preforms was kept low independently of its height. There was no measurable increase in porosity with the water cooling. In addition, the wall width was virtually constant, and the anisotropy of mechanical properties tends to be reduced, characterizing a preform quality improvement. Thus, the NIAC technique offers an efficient and low-cost thermal management approach to mitigate heat accumulation in WAAM and, consequently, also to cope with the deleterious issues related to such emerging alternative of additive manufacturing.
31.	da Silva, Leandro João, et al. (författare) Effect of thermal management approaches on geometry and productivity of thin-walled structures of er 5356 built by wire + arc additive manufacturing 2021 Ingår i: Coatings. - : MDPI. - 2079-6412. ; 11:9 Tidskriftsartikel (refereegranskat)abstract The present paper aimed at assessing the effect of two thermal management approaches on geometry and productivity of thin-walled structures built by Wire + Arc Additive Manufacturing (WAAM). Thin-walls of ER 5356 (Al5Mg) with different lengths and the same number of layers were deposited via the gas metal arc (GMA) process with the aid of an active cooling technique (near-immersion active cooling-NIAC) under a fixed set of deposition parameters. Then, the same experiment was performed with natural cooling (NC) in air. To characterize the thermal management approaches, the interpass temperature (i.e., the temperature at which subsequent layers are deposited) were monitored by a trailing/leading infrared pyrometer during the deposition time. Finally, thin walls with a fixed length were deposited using the NC and NIAC approaches with equivalent interpass temperatures. As expected, the shorter the wall length the more intense the deposition concentration, heat accumulation, and, thus, geometric deviation. This behavior was more evident and premature for the NC strategy due to its lower heat sinking effectiveness. The main finding was that, regardless of the thermal management technique applied, if the same interpass temperature is selected and maintained, the geometry of the part being built tends to be stable and very similar. However, the total deposition time is somewhat shorter with the NIAC technique due its greater heat sinking advantage. Thus, the NIAC technique facilitates the non-stop manufacturing of small parts and details via WAAM. Â© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
32.	da Silva, Leandro Joao, et al. (författare) Work Envelope Expansion and Parametric Optimization in WAAM with Relative Density and Surface Aspect as Quality Constraints : The Case of Al5Mg Thin Walls with Active Cooling 2021 Ingår i: JOURNAL OF MANUFACTURING AND MATERIALS PROCESSING. - : MDPI. - 2504-4494. ; 5:2 Tidskriftsartikel (refereegranskat)abstract The successful and efficient production of parts with specific features by Wire + Arc Additive Manufacturing (WAAM) strongly depends on the selection of proper and typically interrelated deposition parameters. This task might be particularly challenging in the making of thin walls, which might be highly impacted by processing conditions and heat accumulation. In this context, this study aims at expanding the work envelope and optimizing the parametric conditions in WAAM with relative density and surface aspects of the preforms as quality constraints. The experimental approach was based on the deposition of thin Al5Mg walls by the CMT process on its standard welding setup and with an active cooling technique to enhance the deposition robustness. Internal voids were estimated by Archimedes’ method. The surface quality of the walls was assessed through the visual aspect and the surface waviness by cross-section analysis. All the conditions presented relative density higher than 98%. The upgrade of the standard welding hardware to WAAM purposes through the addition of a supplementary shielding gas nozzle to the torch and the intensity of the heat sinking from the part significantly expanded the process work envelope, with its applicability being successfully demonstrated with multi-objective optimization. To sum up, a decision-making procedure is presented towards achieving intended preform quality.
33.	da Silva Ramos, Alessandro, et al. (författare) Synthesis of new CO2 hydrate inhibitors 2020 Ingår i: Journal of Natural Gas Science and Engineering. - : Elsevier. - 1875-5100 .- 2212-3865. ; 75, s. 1-6 Tidskriftsartikel (refereegranskat)abstract Gas hydrate is a crystalline compound made of water and mainly of gases methane and carbon dioxide under specific conditions of pressure and temperature. Increasing worldwide petroleum exploitation in deep waters, where these conditions are encountered, favours the precipitation of gas hydrate in seafloor pipelines, resulting in partial or total obstruction of petroleum flow. Brazil's largest petroleum reserves of the pre-salt interval, for example, are located in ultra-deep waters (>1500 m) and may have a gas composition of up to 80% of CO2. Huge investments are necessary to inhibit the formation of gas hydrate and to assure petroleum flow in pipelines. Here we present the results of the synthesis of new organic compounds obtained from L-Threonine, which show a high potential to be used as CO2 hydrate inhibitors. This characteristic is related to the increase carbon chain in each molecule (higher hydrophobicity) leading to a reduction on CO2 solubility in water. In addition to that, our study also shows the occurrence of the “salting out effect” and reduced water activity coefficient.
34.	de Castro Araujo Moreira, Andrea Cristina, et al. (författare) The first Brazilian Field Lab fully dedicated to CO2 MMV experiments : from the start-up to the initial results 2014 Ingår i: 12th International Conference on Greenhouse Gas Control Technologies, GHGT-12. - : Elsevier. ; , s. 6227-6238 Konferensbidrag (refereegranskat)abstract Currently one of the main challenges in CO2 storage research is the development, testing and validation of accurate and efficient Measuring, Monitoring and Verification (MMV) techniques to be deployed at geological sequestration sites that are cost effective yet help minimize risk. This perspective motivated PETROBRAS, the National Oil Major in Brazil, through its R&D investments portfolio to prioritize research projects that would contribute to decreasing the technological gap in the area. The Company's periodic surveys indicated the lack of infrastructure, as well as expertise in CO2 MMV, as two of the most critical issues at the national level. In order to bridge that gap, initial steps were taken in 2010 for the start-up and development of the first CO2 MMV Field Lab in Brazil, fully sponsored by PETROBRAS, with a long term goal of enabling the ranking of the best, most cost-effective MMV technology alternatives to be deployed at commercial large scale CCGS sites scheduled to be installed in the country. In addition to providing basic infrastructure to carry out the CO2 injection and controlled release experiments, the facility was designed for the simultaneous testing of multiple measuring methodologies. Additional benefits of the initiative are the creation of expertise and the acceleration of the know-how in MMV in Brazil, as well as the development of a deeper and more practical knowledge of CO2 dynamics and impacts in a real world, open air scenario. Under the full support of the PETROBRAS R&D Center (CENPES), through its Climate Change Mitigation Technological Program (PROCLIMA), the Brazilian Pilot CO2 MMV Lab was made possible through a joint 4-year research Project, conceived and carried out by PETROBRAS and local academia in Brazil, in close cooperation with international experts. An overview of the Project and the multiple research areas encompassed will be presented, together with the preliminary results of the first CO2 injection campaign, which took place in 2013. (c) 2014 The Authors. Published by Elsevier
35.	Dias, Pedro, et al. (författare) Geophysical investigation of the down-dip extension of the Lombador massive sulphide deposit, Neves-Corvo, Portugal 2021 Ingår i: International journal of earth sciences. - : Springer Nature. - 1437-3254 .- 1437-3262. ; 110:3, s. 911-922 Tidskriftsartikel (refereegranskat)abstract The 150 Mt Lombador massive sulphide deposit is one of the seven known deposits of the Neves-Corvo mine. The deposit dips approximately 30o-35o to the NE and is open down dip, with current exploitation reaching down at 1 km depth. To investigate the possible downwards continuation of the deposit, a 1D constrained inversion of time-domain electromagnetic (TEM) ground loop data was conducted, followed by 3D electromagnetic (EM) forward modeling and a constrained 3D gravimetric inversion over the same area. To perform the EM and gravity modeling/inversion, a 3D geologic model was built using a density database comprising of approximately 300 drill-holes, and an electrical conductivity database with measurements from resistivity surveys and 1D inversion of the TEM data. The EM modeling shows that the Neves Formation shales are a regional conductive layer extending down to approximately 1.6 km depth in the Lombador area. This layer, often topped by massive sulphides, has an average density of 2.83 g/cm(3), whereas stockwork and massive sulphide reach on average 3.1 g/cm(3) and 4.5 g/cm(3), respectively. The 3D constrained gravity inversion results do not support the hypothesis of the presence of massive sulphides located in the down-dip direction of the Lombador deposit in the immediate vicinity of the known deposit. The lack of spatial resolution of the gravity grid, the study area limited size and the lack of information from within the basement suggest further studies are required to confirm the presence and amount of stockwork mineralization down-dip the Lombador deposit inside the Neves-Formation or the Phyllite-Quartzite basement.
36.	Donoso, George A., et al. (författare) 3D reflection seismic imaging of volcanogenic massive sulphides at Neves-Corvo, Portugal 2023 Ingår i: Geophysical Prospecting. - : John Wiley & Sons. - 0016-8025 .- 1365-2478. ; 71:7, s. 1116-1131 Tidskriftsartikel (refereegranskat)abstract Three-dimensional reflection seismic data from the Neves-Corvo area, southern Portugal, were reprocessed with the main objective of improving the seismic signature of the Lombador and Semblana volcanogenic massive sulphide deposits. The sensitivity for choosing adequate parameters for targeted imaging, even during the pre-processing stage, such as common-depth point binning size, was studied in detail before the main processing work began helping to optimize bin size parameters; preliminary stacking results from this analysis presented severe acquisition footprint, and seismic targets were not clearly identifiable. Processing results using pre-stack dip move-out and post-stack migration methods show strong moderate to steeply dipping reflections. Several of the observed reflections can be correlated with known lithological contacts, some of which are interpreted to originate from the Semblana and Lombador deposits. Despite the mixed signal-to-noise ratio, the seismic cube reveals both shallow and deep three-dimensional structures, allowing to account for the deposits’ lateral extension beyond the capabilities of two-dimensional seismic imaging alone. Given the data processing approach taken it was possible to distinguish strong diffraction patterns, interpreted as originating from faults and edges of the Lombador deposit, illustrating the usefulness of diffraction patterns for better interpretation of geological features in hard-rock environments.
37.	Donoso, George A., et al. (författare) Innovative seismic imaging of volcanogenic massive sulfide deposits, Neves-Corvo, Portugal – Part 2 : Surface array 2021 Ingår i: Geophysics. - : Society of Exploration Geophysicists. - 0016-8033 .- 1942-2156. ; 86:3, s. B181-B191 Tidskriftsartikel (refereegranskat)abstract Seismic methods are an affordable and effective way of studying the subsurface for mineral exploration. With the goal of testing new technologies for mineral exploration in highly challenging mining areas, in early 2019, an innovative seismic survey was conducted at the Neves-Corvo mine, south Portugal. We have focused on the data and results from the surface array data, whereas other work deals with the underground seismic data. The surface seismic survey consisted of two perpendicular 2D profiles positioned above the known world-class tier-1 Lombador deposit. Simultaneously, a survey inside the active underground mine took place, being unique because it included the testing of a prototype system that enabled accurate GPS-time (microsecond accuracy) synchronization inside the mine tunnels, approximately 650 m below the surface profiles. Due to the active mining operations, the surface data are noisy. To handle this, a carefully tailored processing algorithm was developed and applied to enhance reflections in the data, interpreted to originate from lithologic contacts and the Lombador deposit. The results and interpretations from 2D processing were validated taking advantage of the known deposit geometry using 3D exploding reflector modeling and pseudo-3D cross-dip analysis. These analyses suggest that there is an out-of-plane signature of the Lombador deposit on the surface data. Additionally, source points activated in the exploration tunnels and simultaneously recorded on the surface profiles allowed for the creation of a 2D velocity model that was used for migration and time-to depth conversion, providing a reliable 2D seismic section of the subsurface under the surface profiles. We determine that limited surface coverage 2D surveys and a velocity model derived from the tunnel-to-surface seismic recordings allow for imaging of key subsurface geologic structures and delineating mineral deposits of economic interest.
38.	Donoso, George A., et al. (författare) Potential of legacy 2D seismic data for deep targeting and structural imaging at the Neves-Corvo massive sulphide-bearing deposit, Portugal 2020 Ingår i: Geophysical Prospecting. - : WILEY. - 0016-8025 .- 1365-2478. ; 68:1, s. 44-61 Tidskriftsartikel (refereegranskat)abstract Seismic methods are becoming an established choice for deep mineral exploration after being extensively tested and employed for the past two decades. To investigate whether the early European mineral-exploration datasets had potential for seismic imaging that was overlooked, we recovered a low-fold legacy seismic dataset from the Neves-Corvo mine site in the Iberian Pyrite Belt in southern Portugal. This dataset comprises six 4-6 km long profiles acquired in 1996 for deep targeting. Using today's industry-scale processing algorithms, the world-class, ca. 150 Mt, Lombador massive sulphide and other smaller deposits were better imaged. Additionally, we also reveal a number of shallow but steeply dipping reflections that were absent in the original processing results. This study highlights that legacy seismic data are valuable and should be revisited regularly to take advantage of new processing algorithms and the experiences gained from processing such data in hard-rock environments elsewhere. Remembering that an initial processing job in hard rock should always aim to first obtain an overall image of the subsurface and make reflections visible, and then subsequent goals of the workflow could be set to, for example understanding relative amplitude ratios. The imaging of the known mineralization implies that this survey could likely have been among one of the pioneer studies in the world that demonstrated the capability of directly imaging massive sulphide deposits using the seismic method.
39.	Elias Ortega Paredes, Abraham, et al. (författare) Simulation Performance Enhancement in Automotive Embedded Control Using the Unscented Transform 2020 Ingår i: IEEE Access. - : IEEE. - 2169-3536. ; 8, s. 222041-222049 Tidskriftsartikel (refereegranskat)abstract Automotive embedded systems comprise several domains, such as in software, electrical, electronics, and control. When designing and testing functions at the top level, one generally ignores the uncertainties arising from the electrical and electronic effects, which could lead to an irregular behavior and deteriorate their performance even using the appropriate methodology for designing the embedded control systems. Then, the studies and comparison on the effect of uncertainty in the automotive domain are important to improve the overall performance of those control systems. Here, we explored the uncertainty in control systems using the Monte Carlo (MC) and unscented transform (UT) methods. These methods have been applied to a mobile seat platform (MSP) and a light emitting diode (LED) used for lighting of heavy-duty vehicles. The UT for embedded control systems has shown better performance when compared to the Monte Carlo method, in order to reduce the number of required variables and computational resources in the simulation of failures and test-case generation. Finally, this investigation brings another application for the UT, in order to exemplify its applicability and advantages when compared with the other methods.
40.	Etcheverry, Sebastián, et al. (författare) Microsecond switching of plasmonic nanorods in an all-fiber optofluidic component 2017 Ingår i: Optica. - : Optical Society of America. - 2334-2536. ; 4:8, s. 864-870 Tidskriftsartikel (refereegranskat)abstract As information technologies move from electron-to photon-based systems, the need to rapidly modulate light is of paramount importance. Here, we study the evolution of the electric-field-induced alignment of gold nanorods suspended in organic solvents. The experiments were performed using an all-fiber optofluidic device, which enables convenient interaction of light, electric fields, and the nanorod suspension. We demonstrate microsecond nanorod switching times, three orders of magnitude faster than a traditional Freederickcz-based liquid crystal alignment mechanism. We find that the dynamics of the alignment agrees well with the Einstein-Smoluchowski relationship, allowing for the determination of the rotational diffusion coefficient and polarizability anisotropy of the nanorods as well as the effective length of the ligands capping the nanorods. The ability to dynamically control the optical properties of these plasmonic suspensions coupled with the point-to-point delivery of light from the fiber component, as demonstrated in this work, may enable novel ultrafast optical switches, filters, displays, and spatial light modulators.
41.	Hernandez, Aitor, et al. (författare) Inverted Pendulum Control over an IEEE 802.15.4 Wireless Sensor and Actuator Network 2011 Konferensbidrag (refereegranskat)abstract Recent research efforts are considering the problem of performing control of dynamical systems over wireless sensor and actuator networks. However, existing results lack an experimental evaluation in real platforms. In this demonstration an inverted pendulum system is controlled over an IEEE 802.15.4 wireless sensor and actuator network. This platform can evaluate several sensor networks and control algorithms and is currently used as an educational tool at KTH Royal Institute of Technology, Sweden.
42.	Melo, Clarissa Lovato, et al. (författare) Study of gas tracers for CO2 monitoring 2014 Ingår i: 12th International Conference on Greenhouse Gas Control Technologies, GHGT-12. - : Elsevier. ; , s. 3864-3868 Konferensbidrag (refereegranskat)abstract Gas tracers have been tested libr monitoring and detecting CO, displacement in the underground and eventually leakages to the upper layers in geological storage sites. Commonly used tracers are perfluorocarbons (PFCs) and sulfur hexafluoride (SF6). In Brazil, we are canying out gas tracers studies in laboratory for further application in field test 'facilities. These experiments consist of injecting CO, with perfluorocarbon (perfluoropropane PP and pealuormethylcyclopentane PMCP) at low pressure (ca. 290 psi) in pressurized vessels with different types of sediments and soil samples. After flowing through the sample pores, the tracer is adsorbed into a capillary adsorption tube (CAT) with a specific fiber for perfluorcabon. Then, the tracer is extracted from the CAT through a Thermal Desorption System and subsequently analyzed in a Gas Chromatograph with an Electron Capture Detector (GC ECD). The objective of these experiments is to evaluate the PFCs as a monitoring tool; analyzing the tracer retention times in different sediments, as well as understanding the CATs adsorption capacity and performance. After laboratory tests, field experiments will be conducted in the course of this project. Several experiments of CO2 injection and controlled leaks will be developed in shallow vertical wells at the project site as a continuity of the experiments started at Ressacada Fann Site (Florianopolis, Brazil). The project aim is to understand the flow and dispersion of CO2 in soil and atmosphere simulating an eventual leakage from a geological reservoir using an automated system with a dedicated module for tracers injection into CO2 stream. (C) 2015 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creavativecommons.org/licesses/by-nc-nd/3.0/). Peer-review under responsibility of the Organizing Committee of GLIGT-12
43.	Nguyen, Thanh N, et al. (författare) Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up. 2023 Ingår i: Neurology. - 1526-632X. ; 100:4 Tidskriftsartikel (refereegranskat)abstract Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1-4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4-5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6-0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31-1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82-2.97], 5,656/195,539) of all stroke hospitalizations.There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.This study is registered under NCT04934020.
44.	Oliva, Andresa, et al. (författare) A comparison of three methods for monitoring CO2 migration in soil and shallow subsurface in the Ressacada Pilot site, Southern Brazil 2014 Ingår i: 12th International Conference on Greenhouse Gas Control Technologies, GHGT-12. - : Elsevier. ; , s. 3992-4002 Konferensbidrag (refereegranskat)abstract In a joint R&D project under the full sponsorship of PETROBRAS, the Brazilian National Oil Company, the first CO2 monitoring field lab was started-up in Brazil in 2011. The site chosen, the Ressacada Farm, in the Southern region of the country, offered an excellent opportunity to run controlled CO2 release experiments in soil and shallow subsurface (< 3 m depth). This paper focuses on the presentation and comparison of the results obtained using electrical imaging, CO2 flux measurements and geochemical analysis of the groundwater to monitor CO2 migration in both saturated and unsaturated sand-rich sediments and soil. In 2013 a controlled release campaign was run, covering an area of approximately 6,300 m(2). Commercial food-grade gaseous carbon dioxide was continuously injected at 3 m depth for 12 days. The average injection rate was 90 g/day, totaling ca. 32kg of gas being released. The low injection rate avoided fracturing of the unconsolidated sediments composing the bulk of the local soil matrix. Monitoring techniques deployed during 30 consecutive days, including background characterization, injection and post-injection periods, were: (1) 3D electrical imaging using a Wenner array, (2) soil CO2 flux measurements using accumulation chambers, (3) water sampling and analysis, (4) 3D (tridimensional) and 4D (time-lapsed) electrical imaging covering depth levels to approximately 10 m below the surface. Water geochemical monitoring consisted of the analyses of several chemical parameters, as well as acidity and electrical conductivity in five multi-level wells (2m; 4m and 6 m depth) installed in the vicinity of the CO2 injection well. Comparison of pre- and post-injection electrical imaging shows changes in resistivity values consistent with CO(2)migration pathways. A pronounced increase in resistivity values occurred, from 1,500 ohm. m to 2,000 ohm. m, in the vicinity of the injection well. The accumulation chamber assessment show significant changes in the CO2 flux during the release experiment: maximum values detected were ca. 270 mmol/m(2)/s(during injection) as compared to background values of c.a. 34mmol/m(2)/s. The pH showed variations after CO2 injection in two monitoring wells at 2m, 4m and 6m depth. After the CO2 injection ceased, the lowest pH measured was 4.1, which represents a decrease of 0.5 relative to the background values. Slight variations in the oxidation-reduction potential (Eh) were observed near the CO2 injection well. There was a decreasing trend of this potential, especially in a monitoring well at 6m depth, ranging from 308mV to 229mV, between the background and the injection scenarios. Ppb level increments were detected in the measurements carried out for the major cations (Ca, Mg, Na, and P) and trace elements (Ag, Al, As, B, Ba, Cd, Pb, Cu, Cr, Ni, Mn, S, V, and Zn). Electrical conductivity and alkalinity, however, remained constant throughout the experiment, with values around 40 mu S.cm(-1) and 2.5 mgCaCO(3).L-1, respectively. The response to CO2 injection was not uniformly observed by the different methods deployed on site. The highest percentage change in resistivity values near the injection well occurred 5 days after the injection had started. However the highest percentage changes in the CO2 flux values occurred 9 days after the injection, 4 days after the observed changes in resistivity values. This delay is probably due to the migration time of the gas from 0.5m depth to the surface. (C) 2014 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). Peer-review under responsibility of the Organizing Committee of GHGT-12
45.	Peixoto, Mariana, et al. (författare) Evaluating a privacy requirements specification method by using a mixed-method approach : results and lessons learned 2023 Ingår i: Requirements Engineering. - : Springer Science+Business Media B.V.. - 0947-3602 .- 1432-010X. ; 28:2, s. 229-255 Tidskriftsartikel (refereegranskat)abstract Although agile software development (ASD) has been adopted in the industry, requirements approaches for ASD still neglect non-functional requirements. Privacy has become a concern due to new user demands and data protection laws. Hence, privacy needs to be properly specified, but agile requirements engineering techniques do not explicitly represent privacy requirements and, therefore, are not able to proper analyze such requirements. In this context, Privacy Criteria Method (PCM), an approach to specify privacy in requirements activities, was proposed to produce more complete and detailed privacy requirements. By considering PCM a promising approach to be used in ASD and the importance of empirical evaluation of new methods, we have as objectives: 1 evaluate the ability of PCM to support systems analysts in specifying privacy requirements when used in conjunction with some agile specification methods; and 2 show our lessons learned in conducting empirical research based on an mix-method approach defined to empirically evaluate the suitability of a requirements specification in specifying privacy requirements. Mixed-method approach is a controlled experiment as a quantitative evaluation and a feasibility study (questionnaire and task analysis based) study as a qualitative and quantitative evaluation. The requirements specifications following PCM allow to represent privacy aspects, such as user’s personal data and the privacy mechanism that can be used to mitigate a privacy risk scenario. We also observed that some extra time is necessary to specify privacy requirements with PCM, but it does not imply a greater perceived effort. Specifications produced with PCM are of good quality and more privacy detailed. Additionally, we attest to the importance of conducting empirical research to evaluate new methods. PCM assists in specifying more complete and detailed in relation to traditional techniques used in ASD, which facilitates communication between the requirements analysts and developers. © 2022, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
46.	Peixoto, Mariana, et al. (författare) On Understanding How Developers Perceive and Interpret Privacy Requirements Research Preview 2020 Ingår i: Lecture Notes in Computer Science. - Cham : Springer. - 9783030444280 ; , s. 116-123 Konferensbidrag (refereegranskat)abstract [Context and motivation] Ensuring privacy of users’ data has become a top concern in software development, either to satisfy users’ needs or to comply with privacy laws. The problem may increase by the time a new law is in the vacancy period, and companies are working to understand how to comply with it. In addition, research has shown that many developers do not have sufficient knowledge about how to develop privacy-sensitive software. [Question/problem] Motivated by this scenario, this research investigates the personal factors affecting the developers’ understanding of privacy requirements during the vacancy period of a data protection law. [Principal ideas/results] We conducted thirteen interviews in six different private companies. As a result, we found nine personal factors affecting how software developers perceive and interpret privacy requirements. [Contribution] The identification of the personal factors contributes to the elaboration of effective methods for promoting proper privacy-sensitive software development. © 2020, Springer Nature Switzerland AG.
47.	Peixoto, Mariana, et al. (författare) The perspective of Brazilian software developers on data privacy 2023 Ingår i: Journal of Systems and Software. - : Elsevier. - 0164-1212 .- 1873-1228. ; 195 Tidskriftsartikel (refereegranskat)abstract Context: Maintaining the privacy of user data is a concern in software development to satisfy customer needs or to comply with privacy laws. Recent studies have shown that software development approaches still neglect non-functional requirements, including privacy. Concern about privacy may increase in the period between when a privacy law is initially announced and when it is passed into law. During this period, companies will be challenged to comply with the new law. Research has shown that many developers do not have sufficient knowledge to develop privacy-preserving software systems.Objective: We investigate the level of knowledge and understanding that developers possess regarding privacy. We explore the personal, behavioural, and external environmental factors affecting a developer's decision-making regarding privacy requirements.Methods: We replicated a study by means of in-depth, semi-structured interviews with thirteen practitioners at six companies. Our data analysis is based on the principles of ‘grounded theory codification’.Results: We identified nine personal factors, five behavioural factors, and seven external environment factors that are relevant to how software developers make decisions regarding.Conclusion: Our identification of factors that influence the development of privacy-preserving software systems can be seen as a contribution to the specification of effective methods for securing privacy. © 2022 Elsevier Inc.
48.	Pires, Ana Elisabete, et al. (författare) The curious case of the Mesolithic Iberian dogs : An archaeogenetic study 2019 Ingår i: Journal of Archaeological Science. - : Elsevier BV. - 0305-4403 .- 1095-9238. ; 105, s. 116-129 Tidskriftsartikel (refereegranskat)abstract We investigated the genetic composition of six Canis remains from western Iberia, directly radiocarbon dated to 7,903-7,570 years (cal BP). They were identified as dogs via their archaeological and depositional context, osteometry, and a high percentage of aquatic diet shared with humans. For comparison, genetic data were obtained from an additional 37 Iberian dog remains from the Neolithic to Late Antiquity, as well as two Palaeolithic and a Chalcolithic Canis identified as wolves. Previous data indicated that dog mtDNA haplogroup A (HgA) is prevalent in extant European dogs ( > 50%), in the Near East and Asia, but rare or absent ( < 10%) in European Canis older than 3,000 years (cal BP). We found a high frequency (83%) of dog HgA in Mesolithic Iberian dog remains. This is the first report of a high frequency of dog HgA in pre-Neolithic Europe. We show that, contrary to the current view, Canis with HgA did not necessarily arrive in Europe from East-Asia. This phylogeographical difference in HgA frequency demonstrates that genetic differentiation was high prior to, or as a consequence of, domestication which may be linked with pre-Neolithic local processes for Iberian wolf domestication. Our results emphasize that knowledge of both ancient wolves' and early dogs' genetic profiles from the European periphery should improve our understanding of the evolution of the European dog.
49.	Ramos, Alessandro da S., et al. (författare) Geochemical Characterization of Irati And Palermo Formations (Parana Basin-Southern Brazil) for Shale Oil/Gas Exploration 2015 Ingår i: Energy Technology. - : Wiley-Blackwell. - 2194-4288. ; 3:5, s. 481-487 Tidskriftsartikel (refereegranskat)abstract Shale gas/oil currently are two of the most important unconventional energy resources. Their exploitation has caused an energy revolution in USA, and many countries are investing in it. Brazil has large areas covered with sedimentary basins, but little attention has been devoted to the study of shale containing oil and gas. The parameters analyzed and studied for geochemical data evaluation are: clay mineral identification, mineral matter analysis, elemental analysis (including total organic carbon, total carbon, H, N, and S), and the methane adsorption capacity of shale. Adsorption in Palermo Formation samples (depth 238.5m) was 13.72cm(3)g(-1) and for samples from Irati Formation (depth 218.45, 95.3, and 107.5m) 11.73, 6.17, and 4.61cm(3)g(-1).
50.	Rodrigues, Gabriel S., et al. (författare) GoalD: A Goal-Driven Deployment Framework for Dynamic and Heterogeneous Computing Environments 2019 Ingår i: Information and Software Technology. - : Elsevier BV. - 0950-5849. ; 111, s. 159-176 Tidskriftsartikel (refereegranskat)abstract Context Emerging paradigms like Internet of Things and Smart Cities utilize advanced sensing and communication infrastructures, where heterogeneity is an inherited feature. Applications targeting such environments require adaptability and context-sensitivity to uncertain availability and failures in resources and their ad-hoc networks. Such heterogeneity is often hard to predict, making the deployment process a challenging task. Objective This paper proposes GoalD as a goal-driven framework to support autonomous deployment of heterogeneous computational resources to fulfill requirements, seen as goals, and their correlated components on one hand, and the variability space of the hosting computing and sensing environment on the other hand. Method GoalD comprises an offline and an online stage to fulfill autonomous deployment by leveraging the use of goals. Deployment configuration strategies arise from the variability structure of the Contextual Goal Model as an underlying structure to guide autonomous planning by selecting available as well as suitable resources at runtime. Results We evaluate GoalD on an existing exemplar from the self-adaptive systems community – the Tele Assistance Service provided by Weyns and Calinescu [1]. Furthermore, we evaluate the scalability of GoalD on a repository consisting of 430,500 artifacts. The evaluation results demonstrate the usefulness and scalability of GoalD in planning the deployment of a system with thousands of components in a few milliseconds. Conclusion GoalD is a framework to systematically tackle autonomous deployment in highly heterogeneous computing environments, partially unknown at design-time following a goal-oriented approach to achieve the user goals in a target environment. GoalD has demonstrated itself able to scale for deployment planning dealing with thousands of components in a few milliseconds.

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